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==See also==
*[[Invasive breast cancer]].
*[[DCIS]].
==References==
{{Reflist|1}}
[[Category:Invasive breast cancer]]
[[Category:Diagnosis]]
e33c4569847b9982154f89d98d968d7c9a3cd4b628b413e9d2aed445fb3d7128 librepath-idc-breast.txt
{{ Infobox diagnosis
| Name = {{PAGENAME}}
| Image = Intraductal_papilloma_histopathology_(1).jpg
| Width =
| Caption = Intraductal papilloma. [[H&E stain]].
| Synonyms = breast papilloma
| Micro = true papillae (nipple-shaped structures with fibrovascular cores), intraductal proliferation of epithelial and myoepithelial elements, +/-hyalinization
| Subtypes =
| LMDDx = intraductal papilloma with [[florid epithelial hyperplasia]], intraductal papilloma with [[atypical ductal hyperplasia]], intraductal papilloma with [[ductal carcinoma in situ]], [[invasive papillary carcinoma of the breast]].
| Stains =
| IHC =
| EM =
| Molecular =
| IF =
| Gross =
| Grossing =
| Site = [[breast]]
| Assdx =
| Syndromes =
| Clinicalhx =
| Signs = +/-nipple discharge
| Symptoms =
| Prevalence = common
| Bloodwork =
| Rads =
| Endoscopy =
| Prognosis = benign
| Other =
| ClinDDx =
| Tx = usually excision
}}
'''Intraductal papilloma of the breast''', also '''papilloma''' and '''[[intraductal papilloma]]''', is a relatively common benign [[breast pathology|pathology of the breast]].
==General==
*May cause nipple discharge.<ref>{{Cite journal | last1 = Zervoudis | first1 = S. | last2 = Iatrakis | first2 = G. | last3 = Economides | first3 = P. | last4 = Polyzos | first4 = D. | last5 = Navrozoglou | first5 = I. | title = Nipple discharge screening. | journal = Womens Health (Lond Engl) | volume = 6 | issue = 1 ...
*Similar to ''[[papillary hidradenoma]]'' of the [[vulva]].
*Usually excised to exclude malignancy.
**Risk very low if ''not'' associated with a mass or suspicious radiologic findings - conservative management may be reasonable.<ref name=pmid24444467>{{Cite journal | last1 = Weisman | first1 = PS. | last2 = Sutton | first2 = BJ. | last3 = Siziopikou | first3 = KP. | last4 = Hansen | first4 = N. | last5 = Khan | firs...
==Microscopic==
Features:
*True papillae - nipple-shaped structures with fibrovascular cores.
*Intraductal proliferation of epithelial and myoepithelial elements.<ref name=pmid2123505>{{Cite journal | title = Adenoma of Nipple. | journal = Br Med J | volume = 1 | issue = 5330 | pages = 563 | month = Mar | year = 1963 | doi = | PMID = 20789667 | PMC = 2123505 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PM...
Notes:
*Lacks florid hyperplasia.<ref>URL: [http://surgpathcriteria.stanford.edu/breast/nippleadenoma/printable.html http://surgpathcriteria.stanford.edu/breast/nippleadenoma/printable.html]. Accessed on: 6 August 2011.</ref>
*May degeneration and hyalinize to form a ''sclerosing papilloma''.
*When many ducts are involved the process is termed 'papillomatosis'.
DDx:
*Intraductal papilloma with [[florid epithelial hyperplasia]].
*Intraductal papilloma with [[atypical ductal hyperplasia]]. †
*Intraductal papilloma with [[ductal carcinoma in situ]]. †
*[[Ductal carcinoma in situ]] - papillary variant
*[[Invasive papillary carcinoma of the breast]].
† Size criteria are different in papillomas.
===Images===
<gallery>
Image:Intraductal_papilloma_histopathology_(1).jpg | IP. (WC/KGH)
Image:Intraductal papilloma histopathology (2) smooth muscle actin.JPG | IP - SMA. (WC/KGH)
Image:Intraductal_papilloma_histopathology_(3)_p63.JPG | IP - p63 (WC/KGH)
Image:Breast IntraductalPapillomatosis LP CTR.jpg|Breast - Intraductal Papillomatosis with some usual type epithelial hyperplasia - Low power (SKB)
Image:Breast IntraductalPapillomatosis MP2 CTR.jpg|Breast - Intraductal Papillomatosis with some usual type epithelial hyperplasia - Medium power (SKB)
Image:Breast IntraductalPapilloma LP PA.JPG|Breast - Intraductal Papilloma - Low power (SKB)
Image:Breast IntraductalPapilloma MP PA.JPG|Breast - Intraductal Papilloma - Medium power (SKB)
Image:Breast IntraductalPapilloma HP PA.JPG|Breast - Intraductal Papilloma - High power (SKB)
Image:Breast IntraductalPapilloma LP (2) PA.JPG|Breast - Intraductal Papilloma - Low power (SKB)
Image:Breast IntraductalPapilloma Histiocytes MP PA.JPG|Breast - Intraductal Papilloma - Histiocytes - High power (SKB)
</gallery>
==IHC==
Features:<ref name=pmid22612506>{{Cite journal | last1 = Furuya | first1 = C. | last2 = Kawano | first2 = H. | last3 = Yamanouchi | first3 = T. | last4 = Oga | first4 = A. | last5 = Ueda | first5 = J. | last6 = Takahashi | first6 = M. | title = Combined evaluation of CK5/6, ER, p63, and MUC3 for distinguishing breast ...
</ref>
*[[CK5/6]] +ve.
*[[p63]] +ve.
*MUC3 weak.
*ER weak.
**Strong in [[DCIS]].
==Sign out==
<pre>
Right Breast, Partial Mastectomy:
- Intraductal papilloma.
- Proliferative fibrocystic changes.
- NEGATIVE for malignancy.
</pre>
==See also==