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DDx:
*[[Liposarcoma]] - increased number of blood vessels,<ref name=pmid11685482>{{Cite journal | last1 = Yang | first1 = YJ. | last2 = Damron | first2 = TA. | last3 = Cohen | first3 = H. | last4 = Hojnowski | first4 = L. | title = Distinction of well-differentiated liposarcoma from lipoma in two patients with multiple wel...
*Benign adipose tissue.
Images:
*[http://circ.ahajournals.org/content/113/21/e778/F5.expansion.html Lipoma - cardiac (ahajournals.org)].<ref name=pmid16735681>{{Cite journal | last1 = Friedberg | first1 = MK. | last2 = Chang | first2 = IL. | last3 = Silverman | first3 = NH. | last4 = Ramamoorthy | first4 = C. | last5 = Chan | first5 = FP. | title = ...
===Variants===
====Angiolipoma====
*A [[painful skin lesions|painful skin lesion]].
Microscopic:
*Numerous blood vessels present.
*+/-Microthrombi.
DDx:
*[[Liposarcoma]].
====Myolipoma====
General:
*May mimic a sarcoma radiologically.<ref>URL: [http://www.webmedcentral.com/article_view/1878 http://www.webmedcentral.com/article_view/1878]. Accessed on: 14 March 2013.</ref>
*Extremely rare.<ref name=pmid15371618>{{Cite journal | last1 = Murphey | first1 = MD. | last2 = Carroll | first2 = JF. | last3 = Flemming | first3 = DJ. | last4 = Pope | first4 = TL. | last5 = Gannon | first5 = FH. | last6 = Kransdorf | first6 = MJ. | title = From the archives of the AFIP: benign musculoskeletal lipo...
*Usually large ~ 16 cm.<ref name=pmid1703396>{{Cite journal | last1 = Meis | first1 = JM. | last2 = Enzinger | first2 = FM. | title = Myolipoma of soft tissue. | journal = Am J Surg Pathol | volume = 15 | issue = 2 | pages = 121-5 | month = Feb | year = 1991 | doi = | PMID = 1703396 }}</ref>
Microscopic:<ref name=pmid15371618/>
*Mature adipose tissue.
*Benign smooth muscle - usually ~ 2x amount of fat.
Note:
*If skeletal muscle is present consider ''intramuscular lipoma''.<ref> URL: [http://surgpathcriteria.stanford.edu/softfat/lipoma/intramuscular_lipoma.html http://surgpathcriteria.stanford.edu/softfat/lipoma/intramuscular_lipoma.html]. Accessed on: 14 March 2013.</ref>
IHC:<ref name=pmid15371618/>
*Actin +ve.
*Desmin +ve.
Images:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168809/figure/F1/ Myolipoma (nih.gov)].<ref name=pmid21927569>{{Cite journal | last1 = Lee | first1 = YS. | last2 = Park | first2 = SE. | last3 = Lee | first3 = JU. | last4 = Choi | first4 = ES. | title = MRI of a subcutaneous myolipoma in the ankle: a case report. | jour...
*[http://www.webpathology.com/image.asp?case=431&n=1 Myolipoma (webpathology.com)].
===Images===
<gallery>
Image: Lipoma -- intermed mag.jpg | Lipoma - intermed. mag.
Image: Lipoma -- high mag.jpg | Lipoma - high mag.
Image:Yellow_adipose_tissue_in_paraffin_section_-_lipids_washed_out.jpg | Mature fat. (WC)
</gallery>
==Molecular==
*MDM2/CDK4 gene amplification absent.
**Testing suggested in lesions greater than 10 cm, thigh lesions and lesions with cytologic atypia.<ref name=pmid27020493>{{Cite journal | last1 = Wong | first1 = DD. | last2 = Low | first2 = IC. | last3 = Peverall | first3 = J. | last4 = Robbins | first4 = PD. | last5 = Spagnolo | first5 = DV. | last6 = Nairn | first...
==Sign out==
===Large lesion looks like lipoma===
Bland lesions may be well-differentiated liposarcoma.<ref>URL: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422587/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422587/]. Accessed on: 3 June 2017.</ref> Lesions >10 cm should be of concern.
<pre>
Lesion (Submitted as "Lipoma"), Right Neck, Excision:
- Bland appearing adipose tissue suggestive of lipoma, see comment.
- One benign lymph node.
Comment:
Due to the size of the lesion, the case will be sent to a soft tissue pathologist for review.
</pre>
===Block letter===
<pre>
SUBCUTANEOUS TISSUE ("LIPOMA"), LEFT AXILLA, EXCISION:
- MATURE ADIPOSE TISSUE CONSISTENT WITH LIPOMA.
</pre>
<pre>
LESION ("LIPOMA"), SPERMATIC CORD (LATERALITY NOT SPECIFIED), EXCISION:
- MATURE ADIPOSE TISSUE CONSISTENT WITH LIPOMA.
</pre>
===Colonic lipoma (clinically suspected)===
<pre>
B. SIGMOID COLON AT 55 CM, BIOPSY:
- COLORECTAL-TYPE MUCOSA WITHIN NORMAL LIMITS WITH A SMALL AMOUNT OF SUBMUCOSAL
ADIPOSE TISSUE; COMPATIBLE WITH CLINICAL IMPRESSION OF LIPOMA.
</pre>
===Mirco===
The sections show mature adipocytes. There is no increase in vascularity. No thick fibrous septa are present.
==See also==
*[[Adipocytic tumours]].
==References==
{{Reflist|2}}
[[Category:Diagnosis]]
[[Category:Adipocytic tumours]]
fe7428f4e3c53fde7653e0396c2bd7df09511148ff951d92517e8d87cba1d772 librepath-lipoma.txt
{{ Infobox diagnosis
| Name = {{PAGENAME}}
| Image = Acinar pattern adenocarcinoma of lung -- low mag.jpg
| Width =
| Caption = Invasive adenocarcinoma, acinar pattern (right of image) and benign lung (left of image). [[H&E stain]].
| Synonyms =
| Micro = +/-nuclear atypia (may be absent in mucinous tumours), eccentrically placed nuclei, usu. abundant cytoplasm (classically with mucin vacuoles), often conspicuous [[nucleoli]], +/-[[nuclear pseudoinclusions]]
| Subtypes =