Archive 4 checkpoints (1-4)
Browse files- paper-releases/pbisc-diffusion/updates/20261008T121550Z-deck-fig4-rules-no-broadcast/diffusion/dataset/server_1/model8/presentations/2026-09-30--paper-summary--r00/data/fig3_time_days_slide_text.json +33 -0
- paper-releases/pbisc-diffusion/updates/20261008T121550Z-deck-fig4-rules-no-broadcast/diffusion/dataset/server_1/model8/presentations/2026-09-30--paper-summary--r00/data/fig4_disease_slide_text.json +91 -0
- paper-releases/pbisc-diffusion/updates/20261008T121550Z-deck-fig4-rules-no-broadcast/diffusion/dataset/server_1/model8/presentations/2026-09-30--paper-summary--r00/data/figure_plan.json +368 -0
- paper-releases/pbisc-diffusion/updates/20261008T121550Z-deck-fig4-rules-no-broadcast/diffusion/dataset/server_1/model8/presentations/2026-09-30--paper-summary--r00/data/secS_deconvolution.csv +6 -0
paper-releases/pbisc-diffusion/updates/20261008T121550Z-deck-fig4-rules-no-broadcast/diffusion/dataset/server_1/model8/presentations/2026-09-30--paper-summary--r00/data/fig3_time_days_slide_text.json
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{
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"section": "fig3-time",
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"scripts": [
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"/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/presentations/2026-09-30--paper-summary--r00/tools/fig3_time_days.py"
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],
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"generated_from": "tools/fig3_time_days.py (rerun to refresh; do not edit by hand)",
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"slides": [
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{
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"title": "Time: days for scSemiProfiler, minutes for LoRA",
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"layout": "full",
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"figures": [
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"/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/presentations/2026-09-30--paper-summary--r00/figures/fig3_time_days.png"
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],
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"keywords": [
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"5 donors, 5 draws: 5–20 h vs 13–54 min",
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"5-fold: up to 1.6 days vs 37 min (Sepsis)",
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"All runs: 7.7 days vs 5.7 h"
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],
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"footnote_short": "One GB10 GPU, job alone on it. GPU time from receipts; waits for the GPU excluded.",
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"footnote": "GPU time per cohort on one GB10 GPU with every step alone on the GPU, from each run's receipts; waits for the GPU (our environment) are excluded. Main comparison: 5 donors, i.e. LoRA–5 vs scSemiProfiler with the same 5 pairs as representatives, all 5 draws per cohort. 5–fold CV (the five fold models, every usable sample tested once) is shown separately. scSemiProfiler = pretraining of every representative (two stages) + one model per test sample (upstream c2aea02, default settings); PBISC LoRA = fine–tune + sampling 1,500 cells per test sample. Ratio per cohort: 5 donors 17–59x, 5–fold 19–62x. scSemiProfiler 5–fold running time including its CPU steps: ImMicro (healthy) 27 h; Sepsis 41 h; Imperial 33 h; Giroux 15 h; Ji (whole blood) 8 h. All runs = 25 five–donor draws + 25 fold models: scSemiProfiler 184 h, LoRA 5.7 h. Not counted on either side: data preparation, scoring, and what each method provides (PBISC's pretrained model, scSemiProfiler's code). The equal–pair–budget scSemiProfiler runs are not included (they reuse the 5–fold run's representative models). Sources: data/sec09_same_pairs.csv, data/sec09_time_to_apply.csv, scsemi/work/<cohort>/cv/fold<k>/events.jsonl.",
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"numbers": [
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{
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"value": "ImMicro (healthy): 5 donors (5 draws) scSemiProfiler 11.7 h vs LoRA 0.70 h; 5-fold 23.7 h (0.99 days) vs 1.22 h (19x); Sepsis: 5 donors (5 draws) scSemiProfiler 20.3 h vs LoRA 0.56 h; 5-fold 38.5 h (1.60 days) vs 0.62 h (62x); Imperial: 5 donors (5 draws) scSemiProfiler 19.1 h vs LoRA 0.90 h; 5-fold 30.9 h (1.29 days) vs 0.52 h (60x); Giroux: 5 donors (5 draws) scSemiProfiler 13.0 h vs LoRA 0.22 h; 5-fold 14.4 h (0.60 days) vs 0.30 h (49x); Ji (whole blood): 5 donors (5 draws) scSemiProfiler 4.8 h vs LoRA 0.28 h; 5-fold 7.4 h (0.31 days) vs 0.37 h (20x)",
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"source": "data/fig3_time_days.csv"
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},
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{
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"value": "all runs: scSemiProfiler 183.8 GPU h (7.66 days); PBISC LoRA 5.68 h",
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"source": "data/fig3_time_days.csv"
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}
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]
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}
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]
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}
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paper-releases/pbisc-diffusion/updates/20261008T121550Z-deck-fig4-rules-no-broadcast/diffusion/dataset/server_1/model8/presentations/2026-09-30--paper-summary--r00/data/fig4_disease_slide_text.json
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{
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"section": "fig4-disease",
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"scripts": [
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"/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/presentations/2026-09-30--paper-summary--r00/tools/fig4_disease.py"
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],
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"generated_from": "tools/fig4_disease.py (rerun to refresh; do not edit by hand)",
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"slides": [
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{
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"title": "Disease signal with 5 pairs: LoRA-5 vs others",
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"layout": "full",
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"figures": [
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"/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/presentations/2026-09-30--paper-summary--r00/figures/fig4_disease_fewpair.png"
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],
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"keywords": [
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"vs scSemiProfiler-5: logFC r 13/20, partial r 14/20 draws",
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"Beyond bulk: partial r 0.60 vs 0.43 (Imperial)",
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"Above zero-shot and calibration in 4/4 cohorts"
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],
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"footnote_short": "5 donors, 5 draws; bars = mean, dots = draws. Partial r = cell-type signal beyond the bulk.",
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"footnote": "Main comparison: 5 donors per draw, LoRA–5 vs scSemiProfiler with the same 5 donors as representatives (and the two zero–shot PBISC versions), 5 draws per cohort, every other usable sample tested. logFC r = Pearson r of case–vs–control logFC (mean CP10K) with the observed cells, mean over T, B, monocyte and NK. Partial r = the same after both logFCs are residualised on the input bulk's logFC: the cell–type signal the bulk does not carry. Top–50 DEG: LoRA–5 ahead in 12/20 draws, tied in 8 (Giroux and Ji: few DEG in the observed cells, mostly 0 for every method). Giroux's 5–donor test sets hold 10–12 samples from 4 subjects (2 vs 2), so its disease metrics are noisy; there scSemiProfiler–5 is ahead. Giroux: sex–linked genes excluded (severity is confounded with sex). Per cohort, mean over draws (r / partial r / DEG): Sepsis LoRA–5 0.35 / 0.30 / 16.4, scSemiProfiler–5 0.40 / 0.33 / 5.2; Imperial LoRA–5 0.75 / 0.60 / 113.6, scSemiProfiler–5 0.56 / 0.43 / 46.8; Giroux LoRA–5 0.30 / 0.19 / 0.2, scSemiProfiler–5 0.40 / 0.24 / 0.0; Ji LoRA–5 0.33 / 0.30 / 0.2, scSemiProfiler–5 0.15 / 0.09 / 0.0. Source: data/fig4_disease.csv (scores[_nosex]/<cohort>/fewshot_n5/draw<j>[_scsemi5]).",
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"refs": [
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"Wang 2024, Nat Commun",
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"Viñas Torné 2026, Nat Biotechnol"
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],
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"refs_full": [
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"Wang et al. scSemiProfiler: advancing large-scale single-cell studies through semi-profiling with deep generative models and active learning. Nat Commun 15:5989 (2024). doi:10.1038/s41467-024-50150-1",
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"Viñas Torné et al. Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation. Nat Biotechnol 44:1050-1059 (2026). doi:10.1038/s41587-025-02777-8"
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],
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"numbers": [
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{
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"value": "Sepsis LoRA–5 0.35 / 0.30 / 16.4, scSemiProfiler–5 0.40 / 0.33 / 5.2; Imperial LoRA–5 0.75 / 0.60 / 113.6, scSemiProfiler–5 0.56 / 0.43 / 46.8; Giroux LoRA–5 0.30 / 0.19 / 0.2, scSemiProfiler–5 0.40 / 0.24 / 0.0; Ji LoRA–5 0.33 / 0.30 / 0.2, scSemiProfiler–5 0.15 / 0.09 / 0.0",
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"source": "data/fig4_disease.csv"
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}
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]
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},
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{
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"title": "5-fold CV: disease signal",
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"layout": "full",
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"figures": [
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"/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/presentations/2026-09-30--paper-summary--r00/figures/fig4_disease_fivefold.png"
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],
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"keywords": [
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"logFC r up to 0.82 (Imperial)",
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"vs scSemiProfiler: r 3/4, partial r 3/4, DEG 4/4 cohorts",
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"Top PBISC version on logFC r in 4/4 cohorts"
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],
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"footnote_short": "Donor-level 5-fold CV, pooled; reported separately from the 5-pair comparison.",
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"footnote": "Reported separately from the 5-pair comparison: donor-level 5-fold CV, each sample generated by the fold model that never trained on it, one pooled scoring call per method; scSemiProfiler uses exactly LoRA's training pairs as representatives. Per cohort LoRA vs scSemiProfiler (r / partial r / DEG): Sepsis 0.53 / 0.47 / 23 vs 0.44 / 0.36 / 6; Imperial 0.82 / 0.69 / 143 vs 0.71 / 0.54 / 87; Giroux 0.46 / 0.32 / 5 vs 0.54 / 0.39 / 0; Ji 0.48 / 0.45 / 15 vs 0.27 / 0.23 / 0. Giroux: sex-linked genes excluded. Source: data/fig4_disease.csv (scores[_nosex]/<cohort>/pooled, scsemi_cv_20261002/pooled; sepsis DEG from pooled_deg).",
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"refs": [
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"Wang 2024, Nat Commun",
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"Viñas Torné 2026, Nat Biotechnol"
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],
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"refs_full": [
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"Wang et al. scSemiProfiler: advancing large-scale single-cell studies through semi-profiling with deep generative models and active learning. Nat Commun 15:5989 (2024). doi:10.1038/s41467-024-50150-1",
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| 55 |
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"Viñas Torné et al. Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation. Nat Biotechnol 44:1050-1059 (2026). doi:10.1038/s41587-025-02777-8"
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| 56 |
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],
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"numbers": [
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{
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"value": "Sepsis 0.53 / 0.47 / 23 vs 0.44 / 0.36 / 6; Imperial 0.82 / 0.69 / 143 vs 0.71 / 0.54 / 87; Giroux 0.46 / 0.32 / 5 vs 0.54 / 0.39 / 0; Ji 0.48 / 0.45 / 15 vs 0.27 / 0.23 / 0",
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"source": "data/fig4_disease.csv"
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}
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]
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},
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{
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"title": "Sepsis: fine-tuning variants",
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"layout": "full",
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"figures": [
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| 68 |
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"/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/presentations/2026-09-30--paper-summary--r00/figures/fig4_disease_variants.png"
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],
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"keywords": [
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"LoRA r16 ≈ full fine-tune: r 0.53 vs 0.53",
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"Rank 64: r 0.55, DEG 26 vs 23",
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"Multi-K and recipes: no gain"
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],
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"footnote_short": "Sepsis, 82 donors, pooled 5-fold. LoRA r = 16 is the model used throughout.",
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"footnote": "Sepsis, 82 donors, pooled 5–fold CV, same scorer and donors for every variant. LoRA r = 16 is the model used throughout the deck. Full fine–tune trains all 54.2 M weights, LoRA r16 1.30 M. Multi–K: LoRA trained on K = 250–4,000 conditions; recipes: half of each batch is pseudobulk from the training donors' cells. LoRA r = 4: r 0.476, partial r 0.416, DEG 18; LoRA r = 16 (used): r 0.527, partial r 0.469, DEG 23; LoRA r = 64: r 0.553, partial r 0.492, DEG 26; Full fine–tune: r 0.534, partial r 0.468, DEG 24; LoRA, multi–K: r 0.509, partial r 0.447, DEG 23; LoRA + recipes: r 0.496, partial r 0.431, DEG 23. Source: data/fig4_disease.csv (scores/ye2026_sepsis/{pooled_deg, lora_rank_20261001/pooled}).",
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| 77 |
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"refs": [
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| 78 |
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"Hu 2022, ICLR"
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],
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| 80 |
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"refs_full": [
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| 81 |
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"Hu et al. LoRA: Low-Rank Adaptation of Large Language Models. ICLR 2022"
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],
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"numbers": [
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{
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"value": "LoRA r = 4: r 0.476, partial r 0.416, DEG 18; LoRA r = 16 (used): r 0.527, partial r 0.469, DEG 23; LoRA r = 64: r 0.553, partial r 0.492, DEG 26; Full fine–tune: r 0.534, partial r 0.468, DEG 24; LoRA, multi–K: r 0.509, partial r 0.447, DEG 23; LoRA + recipes: r 0.496, partial r 0.431, DEG 23",
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"source": "data/fig4_disease.csv"
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}
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]
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}
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]
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}
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paper-releases/pbisc-diffusion/updates/20261008T121550Z-deck-fig4-rules-no-broadcast/diffusion/dataset/server_1/model8/presentations/2026-09-30--paper-summary--r00/data/figure_plan.json
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|
| 1 |
+
{
|
| 2 |
+
"source": "Nature Style Manuscript Writing.pdf (paper-release-20260928/reference-papers): six main figures, up to 17 supplementary. User decisions of 2026-10-06: no PBISC-VAE; scSemiProfiler, a VAE-based method, is the comparison. User decisions of 2026-10-08 (supersede the earlier figure split): Fig. 2 shows no disease metrics; Fig. 3 compares with scSemiProfiler on healthy samples, with time as a main result; Figs 4-6 use the disease cohorts: Fig. 4 disease benchmarks (PBISC versions, scSemiProfiler, and BayesPrism / CIBERSORTx labelled as cell-type deconvolution), Fig. 5 rare-cell fractions and detection, Fig. 6 new findings from the bulk-only sepsis and COVID samples (K = 1,000 and 4,000).",
|
| 3 |
+
"status_legend": {
|
| 4 |
+
"Ready": "slide exists and fits the panel",
|
| 5 |
+
"Adapt": "slide exists; change its scope or style",
|
| 6 |
+
"Draft": "new draft exists, not yet approved",
|
| 7 |
+
"Build": "results exist; no slide yet",
|
| 8 |
+
"Run": "needs a new analysis or experiment",
|
| 9 |
+
"Plan": "not planned yet"
|
| 10 |
+
},
|
| 11 |
+
"figures": [
|
| 12 |
+
{
|
| 13 |
+
"n": 1,
|
| 14 |
+
"title": "Design and performance of PBISC",
|
| 15 |
+
"claim": "Diffusion on each gene's value and detection, conditioned on bulk, writes realistic blood cells.",
|
| 16 |
+
"panels": [
|
| 17 |
+
{
|
| 18 |
+
"p": "a",
|
| 19 |
+
"content": "Backbones compared: scDiffusion, SDD, PBISC-Diffusion",
|
| 20 |
+
"evidence": [
|
| 21 |
+
"Backbone: SDD → PBISC-Diffusion"
|
| 22 |
+
],
|
| 23 |
+
"status": "Ready"
|
| 24 |
+
},
|
| 25 |
+
{
|
| 26 |
+
"p": "b",
|
| 27 |
+
"content": "Overview: pretraining, diffusion, generation",
|
| 28 |
+
"evidence": [
|
| 29 |
+
"Overview draft (Nature style)"
|
| 30 |
+
],
|
| 31 |
+
"status": "Draft"
|
| 32 |
+
},
|
| 33 |
+
{
|
| 34 |
+
"p": "c",
|
| 35 |
+
"content": "What the bulk condition contains",
|
| 36 |
+
"evidence": [
|
| 37 |
+
"Bulk conditioning"
|
| 38 |
+
],
|
| 39 |
+
"status": "Ready"
|
| 40 |
+
},
|
| 41 |
+
{
|
| 42 |
+
"p": "d",
|
| 43 |
+
"content": "Pretraining corpus: assays, conditions, cell types",
|
| 44 |
+
"evidence": [
|
| 45 |
+
"Pretraining corpus"
|
| 46 |
+
],
|
| 47 |
+
"status": "Ready"
|
| 48 |
+
},
|
| 49 |
+
{
|
| 50 |
+
"p": "e",
|
| 51 |
+
"content": "Width and context: lower loss, same biology",
|
| 52 |
+
"evidence": [
|
| 53 |
+
"Width & context ablation: loss saturation",
|
| 54 |
+
"Width & context ablation: benchmark"
|
| 55 |
+
],
|
| 56 |
+
"status": "Ready"
|
| 57 |
+
},
|
| 58 |
+
{
|
| 59 |
+
"p": "f",
|
| 60 |
+
"content": "Gene panel: 2k, 3k, 6k, 15k",
|
| 61 |
+
"evidence": [
|
| 62 |
+
"Gene context: 2k / 3k / 6k / 15k"
|
| 63 |
+
],
|
| 64 |
+
"status": "Ready"
|
| 65 |
+
}
|
| 66 |
+
],
|
| 67 |
+
"candidates": [],
|
| 68 |
+
"details": [
|
| 69 |
+
"PBISC-Diffusion: bulk in, cells out",
|
| 70 |
+
"Denoiser: joint value + support diffusion"
|
| 71 |
+
]
|
| 72 |
+
},
|
| 73 |
+
{
|
| 74 |
+
"n": 2,
|
| 75 |
+
"title": "Fine-tuning PBISC with LoRA",
|
| 76 |
+
"claim": "On a healthy cohort, a few pairs and a LoRA of minutes give cells close to the real ones. No disease metrics.",
|
| 77 |
+
"panels": [
|
| 78 |
+
{
|
| 79 |
+
"p": "a",
|
| 80 |
+
"content": "Real bulk differs from the training input",
|
| 81 |
+
"evidence": [
|
| 82 |
+
"Real bulk ≠ pseudobulk (model input)",
|
| 83 |
+
"Same shift in three paired cohorts"
|
| 84 |
+
],
|
| 85 |
+
"status": "Ready"
|
| 86 |
+
},
|
| 87 |
+
{
|
| 88 |
+
"p": "b",
|
| 89 |
+
"content": "Without fine-tuning, cells fall off the real manifold",
|
| 90 |
+
"evidence": [
|
| 91 |
+
"Consequence: cells off-manifold"
|
| 92 |
+
],
|
| 93 |
+
"status": "Ready"
|
| 94 |
+
},
|
| 95 |
+
{
|
| 96 |
+
"p": "c",
|
| 97 |
+
"content": "LoRA on paired bulk and cells; how it is tested",
|
| 98 |
+
"evidence": [
|
| 99 |
+
"Fine-tuning with paired bulk + sc",
|
| 100 |
+
"Evaluation design"
|
| 101 |
+
],
|
| 102 |
+
"status": "Adapt",
|
| 103 |
+
"note": "design example: ImMicro instead of sepsis"
|
| 104 |
+
},
|
| 105 |
+
{
|
| 106 |
+
"p": "d",
|
| 107 |
+
"content": "How generated cells are scored (cells and composition)",
|
| 108 |
+
"evidence": [
|
| 109 |
+
"How we score generated cells"
|
| 110 |
+
],
|
| 111 |
+
"status": "Adapt",
|
| 112 |
+
"note": "disease rows move to Fig. 4"
|
| 113 |
+
},
|
| 114 |
+
{
|
| 115 |
+
"p": "e",
|
| 116 |
+
"content": "Healthy cohort: precision, coverage, composition",
|
| 117 |
+
"evidence": [
|
| 118 |
+
"5-fold CV: train on the other 4 folds"
|
| 119 |
+
],
|
| 120 |
+
"status": "Adapt",
|
| 121 |
+
"note": "ImMicro only; drop the disease columns"
|
| 122 |
+
},
|
| 123 |
+
{
|
| 124 |
+
"p": "f",
|
| 125 |
+
"content": "Healthy cohort: classifier AUROC, MMD, E_N",
|
| 126 |
+
"evidence": [
|
| 127 |
+
"5-fold: realism beyond precision/coverage"
|
| 128 |
+
],
|
| 129 |
+
"status": "Adapt",
|
| 130 |
+
"note": "ImMicro only"
|
| 131 |
+
},
|
| 132 |
+
{
|
| 133 |
+
"p": "g",
|
| 134 |
+
"content": "Full, LoRA and condition-encoder fine-tuning",
|
| 135 |
+
"evidence": [
|
| 136 |
+
"Full vs LoRA vs cond.-encoder-only"
|
| 137 |
+
],
|
| 138 |
+
"status": "Adapt",
|
| 139 |
+
"note": "ImMicro only; no logFC"
|
| 140 |
+
},
|
| 141 |
+
{
|
| 142 |
+
"p": "h",
|
| 143 |
+
"content": "How many pairs are needed",
|
| 144 |
+
"evidence": [
|
| 145 |
+
"Pairs needed: composition, coverage, training steps"
|
| 146 |
+
],
|
| 147 |
+
"status": "Adapt",
|
| 148 |
+
"note": "ImMicro only; scSemiProfiler diamonds go to Fig. 3"
|
| 149 |
+
},
|
| 150 |
+
{
|
| 151 |
+
"p": "i",
|
| 152 |
+
"content": "LoRA rank and K choices",
|
| 153 |
+
"evidence": [
|
| 154 |
+
"LoRA rank: r = 4, 16, 64",
|
| 155 |
+
"K diversification: no gain"
|
| 156 |
+
],
|
| 157 |
+
"status": "Adapt",
|
| 158 |
+
"note": "ImMicro only; supplementary candidate"
|
| 159 |
+
}
|
| 160 |
+
],
|
| 161 |
+
"candidates": [],
|
| 162 |
+
"details": []
|
| 163 |
+
},
|
| 164 |
+
{
|
| 165 |
+
"n": 3,
|
| 166 |
+
"title": "PBISC vs scSemiProfiler on healthy donors",
|
| 167 |
+
"claim": "On healthy donors, LoRA cells are closer to the real ones than scSemiProfiler's, in minutes instead of days.",
|
| 168 |
+
"panels": [
|
| 169 |
+
{
|
| 170 |
+
"p": "a",
|
| 171 |
+
"content": "Five donors: generated cells and realism",
|
| 172 |
+
"evidence": [
|
| 173 |
+
"5 donors: LoRA vs scSemiProfiler — cells",
|
| 174 |
+
"5 donors: realism beyond precision/coverage",
|
| 175 |
+
"5 donors: precision/coverage at k = 3, 5, 10"
|
| 176 |
+
],
|
| 177 |
+
"status": "Adapt",
|
| 178 |
+
"note": "ImMicro only"
|
| 179 |
+
},
|
| 180 |
+
{
|
| 181 |
+
"p": "b",
|
| 182 |
+
"content": "Same training pairs (5-fold) and equal pair budget (5-40)",
|
| 183 |
+
"evidence": [
|
| 184 |
+
"Same training pairs: LoRA vs scSemiProfiler"
|
| 185 |
+
],
|
| 186 |
+
"status": "Adapt",
|
| 187 |
+
"note": "ImMicro only; add the n = 5-40 budget runs"
|
| 188 |
+
},
|
| 189 |
+
{
|
| 190 |
+
"p": "c",
|
| 191 |
+
"content": "scSemiProfiler copies its representative",
|
| 192 |
+
"evidence": [
|
| 193 |
+
"scSemiProfiler copies its representative"
|
| 194 |
+
],
|
| 195 |
+
"status": "Adapt",
|
| 196 |
+
"note": "ImMicro only"
|
| 197 |
+
},
|
| 198 |
+
{
|
| 199 |
+
"p": "d",
|
| 200 |
+
"content": "Time: GPU hours and days per experiment",
|
| 201 |
+
"evidence": [
|
| 202 |
+
"Time: days for scSemiProfiler, minutes for LoRA",
|
| 203 |
+
"5 donors: time to apply"
|
| 204 |
+
],
|
| 205 |
+
"status": "Ready",
|
| 206 |
+
"note": "all cohorts shown: time is a property of the method"
|
| 207 |
+
}
|
| 208 |
+
],
|
| 209 |
+
"candidates": [],
|
| 210 |
+
"details": []
|
| 211 |
+
},
|
| 212 |
+
{
|
| 213 |
+
"n": 4,
|
| 214 |
+
"title": "Disease signal on paired cohorts",
|
| 215 |
+
"claim": "LoRA cells recover the paired single cells' disease signal; compared with other PBISC versions, scSemiProfiler and deconvolution.",
|
| 216 |
+
"panels": [
|
| 217 |
+
{
|
| 218 |
+
"p": "a",
|
| 219 |
+
"content": "Five paired cohorts",
|
| 220 |
+
"evidence": [
|
| 221 |
+
"Five paired cohorts"
|
| 222 |
+
],
|
| 223 |
+
"status": "Ready"
|
| 224 |
+
},
|
| 225 |
+
{
|
| 226 |
+
"p": "b",
|
| 227 |
+
"content": "With 5 pairs: LoRA-5 vs PBISC versions and scSemiProfiler-5",
|
| 228 |
+
"evidence": [
|
| 229 |
+
"Disease signal with 5 pairs: LoRA-5 vs others"
|
| 230 |
+
],
|
| 231 |
+
"status": "Ready",
|
| 232 |
+
"note": "main comparison"
|
| 233 |
+
},
|
| 234 |
+
{
|
| 235 |
+
"p": "c",
|
| 236 |
+
"content": "5-fold CV, reported separately",
|
| 237 |
+
"evidence": [
|
| 238 |
+
"5-fold CV: disease signal"
|
| 239 |
+
],
|
| 240 |
+
"status": "Ready"
|
| 241 |
+
},
|
| 242 |
+
{
|
| 243 |
+
"p": "d",
|
| 244 |
+
"content": "Disease genes at every list length (CAT)",
|
| 245 |
+
"evidence": [
|
| 246 |
+
"Disease genes at every list length (CAT)"
|
| 247 |
+
],
|
| 248 |
+
"status": "Ready"
|
| 249 |
+
},
|
| 250 |
+
{
|
| 251 |
+
"p": "e",
|
| 252 |
+
"content": "vs BayesPrism and CIBERSORTx (cell-type deconvolution)",
|
| 253 |
+
"evidence": [
|
| 254 |
+
"Cell-type deconvolution, same pairs: disease signal"
|
| 255 |
+
],
|
| 256 |
+
"status": "Ready"
|
| 257 |
+
},
|
| 258 |
+
{
|
| 259 |
+
"p": "f",
|
| 260 |
+
"content": "Lupus benchmark (sc-pseudobulk input, zero-shot)",
|
| 261 |
+
"evidence": [
|
| 262 |
+
"SLE benchmark: PBISC vs scSemiProfiler",
|
| 263 |
+
"SLE benchmark: per cell type"
|
| 264 |
+
],
|
| 265 |
+
"status": "Ready"
|
| 266 |
+
}
|
| 267 |
+
],
|
| 268 |
+
"candidates": [],
|
| 269 |
+
"details": [
|
| 270 |
+
"Sepsis: fine-tuning variants",
|
| 271 |
+
"Pairs needed: donor and disease signal",
|
| 272 |
+
"Cell-type deconvolution, same pairs: composition"
|
| 273 |
+
]
|
| 274 |
+
},
|
| 275 |
+
{
|
| 276 |
+
"n": 5,
|
| 277 |
+
"title": "Rare cell states in disease cohorts",
|
| 278 |
+
"claim": "LoRA cells carry rare disease states near their observed fractions, in the donors that have them.",
|
| 279 |
+
"panels": [
|
| 280 |
+
{
|
| 281 |
+
"p": "a",
|
| 282 |
+
"content": "Rare-state fractions, generated vs observed, four paired cohorts",
|
| 283 |
+
"evidence": [],
|
| 284 |
+
"status": "Run",
|
| 285 |
+
"note": "LoRA, scSemiProfiler, zero-shot; BayesPrism states where defined"
|
| 286 |
+
},
|
| 287 |
+
{
|
| 288 |
+
"p": "b",
|
| 289 |
+
"content": "Finding rare states: per-donor detection",
|
| 290 |
+
"evidence": [],
|
| 291 |
+
"status": "Run",
|
| 292 |
+
"note": "donors with vs without the state"
|
| 293 |
+
},
|
| 294 |
+
{
|
| 295 |
+
"p": "c",
|
| 296 |
+
"content": "Behçet: C1Q-high monocytes from real bulk",
|
| 297 |
+
"evidence": [
|
| 298 |
+
"Consequence: disease direction flips"
|
| 299 |
+
],
|
| 300 |
+
"status": "Adapt",
|
| 301 |
+
"note": "add the LoRA-3 result (C1Q-high BD > HC)"
|
| 302 |
+
},
|
| 303 |
+
{
|
| 304 |
+
"p": "d",
|
| 305 |
+
"content": "Diseases absent from the corpus: Kawasaki MS1, SLE ISG-high T",
|
| 306 |
+
"evidence": [],
|
| 307 |
+
"status": "Build",
|
| 308 |
+
"note": "rare_states_screen_20261004 results"
|
| 309 |
+
}
|
| 310 |
+
],
|
| 311 |
+
"candidates": [],
|
| 312 |
+
"details": []
|
| 313 |
+
},
|
| 314 |
+
{
|
| 315 |
+
"n": 6,
|
| 316 |
+
"title": "Discovery from public bulk-only data",
|
| 317 |
+
"claim": "New findings from LoRA cells of bulk-only sepsis and COVID dialysis samples (K = 1,000 and 4,000).",
|
| 318 |
+
"panels": [
|
| 319 |
+
{
|
| 320 |
+
"p": "a",
|
| 321 |
+
"content": "Bulk-only samples generated: sepsis 122, COVID dialysis 164",
|
| 322 |
+
"evidence": [
|
| 323 |
+
"Next: cohorts with a paired subset (planned)"
|
| 324 |
+
],
|
| 325 |
+
"status": "Adapt",
|
| 326 |
+
"note": "update: K = 1,000 and 4,000 done"
|
| 327 |
+
},
|
| 328 |
+
{
|
| 329 |
+
"p": "b",
|
| 330 |
+
"content": "New findings",
|
| 331 |
+
"evidence": [],
|
| 332 |
+
"status": "Run",
|
| 333 |
+
"note": "earlier screen: 0 confirmed beyond the bulk"
|
| 334 |
+
}
|
| 335 |
+
],
|
| 336 |
+
"candidates": [],
|
| 337 |
+
"details": []
|
| 338 |
+
}
|
| 339 |
+
],
|
| 340 |
+
"supplementary": {
|
| 341 |
+
"slides": [
|
| 342 |
+
"Pairs from other cohorts do not transfer",
|
| 343 |
+
"Longer training on other cohorts: gap stays",
|
| 344 |
+
"No pretraining: same cohort, from scratch",
|
| 345 |
+
"No pretraining: other cohorts, from scratch",
|
| 346 |
+
"Rare states: from scratch vs pretrained"
|
| 347 |
+
],
|
| 348 |
+
"planned": [
|
| 349 |
+
{
|
| 350 |
+
"p": "S",
|
| 351 |
+
"content": "Influenza exposure from raw clinical bulk (Randolph)",
|
| 352 |
+
"evidence": [],
|
| 353 |
+
"status": "Build",
|
| 354 |
+
"note": "manuscript result; placement open"
|
| 355 |
+
}
|
| 356 |
+
],
|
| 357 |
+
"notes": {
|
| 358 |
+
"Pairs from other cohorts do not transfer": "moved from Fig. 5; placement open",
|
| 359 |
+
"Longer training on other cohorts: gap stays": "moved from Fig. 5; placement open"
|
| 360 |
+
}
|
| 361 |
+
},
|
| 362 |
+
"appendix": [
|
| 363 |
+
"Appendix: scSemiProfiler without output threshold"
|
| 364 |
+
],
|
| 365 |
+
"discussion": [
|
| 366 |
+
"Next: other tissues from a few dozen pairs"
|
| 367 |
+
]
|
| 368 |
+
}
|
paper-releases/pbisc-diffusion/updates/20261008T121550Z-deck-fig4-rules-no-broadcast/diffusion/dataset/server_1/model8/presentations/2026-09-30--paper-summary--r00/data/secS_deconvolution.csv
ADDED
|
@@ -0,0 +1,6 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
+
cohort,f_lora_l1,f_bp_l1,f_cx_l1,c_lora_l1,c_bp_l1,c_cx_l1,c_scsemi_l1,f_lora_r,f_lora_partial,f_lora_deg,f_bp_r,f_bp_partial,f_bp_deg,f_cx_r,f_cx_partial,f_cx_deg
|
| 2 |
+
ImMicro,0.1755595893035838,0.5374450557106532,0.49140827856730807,0.1617289035078621,0.5745628784374615,0.5065033643252109,0.2170087237986556,,,,,,,,,
|
| 3 |
+
Sepsis,0.4661935856958568,0.4461497190936295,0.5821898971787263,0.3618246783833512,0.4750523423944086,0.607149641152929,0.5022299158951089,0.3501183786066874,0.30469762374899834,16.4,0.24118586866067449,0.09459917525726311,27.0,0.0691472644717398,-0.00988830062408914,25.4
|
| 4 |
+
Ji ChILI,0.5130875970575781,0.8932363204937289,0.8267482537726828,0.5044992874562503,0.8832571878464304,0.914073829946989,0.575388570715078,0.33313865479653937,0.3004989267312548,0.2,0.19324923766266502,0.03175063444356422,2.0,0.15848363999937304,0.0048928823034919515,0.0
|
| 5 |
+
Imperial,0.5029703261097016,0.8445385293550187,0.6455487576081367,0.3763856087574566,0.8870870830413495,0.5918271288164071,0.5203155086290455,0.7491552706205521,0.6028412048970822,113.6,0.5976127405567618,0.1866076529400855,72.4,0.2834999227020752,0.06094785618071251,30.8
|
| 6 |
+
Giroux,0.25643971843189417,1.4554372974895542,0.6693819873634712,0.2580442754044374,0.8778647964495544,0.5914100321768722,0.2430769027717485,0.2965942782817652,0.18857337655691103,0.2,0.3714147659649227,0.11665014209738915,0.2,0.09549187007462323,0.0286423958767148,0.0
|