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paper-releases/pbisc-diffusion/updates/20261005T142225Z-rare-states-scratch-vs-pretrained/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/out/scratch_vs_lora_20261005/verify_recompute_cross_obsdepth_report.txt ADDED
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1
+ observed cells of the 82 donors: 589478 of 610713
2
+ observed monocytes 111269 T cells 298117
3
+ observed median library (measured genes): monocytes 2821.0 T cells 1981.0 all 1967.0
4
+ sanity native C1Q 6788 csv 6788 | MS1 18712 csv 18712
5
+ thin mono_mean_detected_of_73 mono_umis_per_detected mono_HLA-DRA mono_C1Q_pct T_mean_detected_of_73 T_NKG7 T_GZMA
6
+ 1.00 12.0037 4.2142 0.7443 6.1005 5.6547 0.3629 0.3227
7
+ 0.90 11.4998 3.9597 0.7292 6.0107 5.3776 0.3574 0.3158
8
+ 0.80 10.9287 3.7018 0.7107 5.9262 5.0836 0.3519 0.3080
9
+ 0.70 10.3000 3.4362 0.6890 5.7860 4.7548 0.3451 0.2981
10
+ 0.60 9.5738 3.1711 0.6634 5.6512 4.3952 0.3376 0.2859
11
+ 0.50 8.7485 2.8908 0.6297 5.4903 3.9834 0.3283 0.2695
12
+ 0.45 8.2917 2.7472 0.6100 5.3753 3.7618 0.3234 0.2599
13
+ 0.40 7.7758 2.6026 0.5878 5.2863 3.5188 0.3171 0.2488
14
+ 0.35 7.2314 2.4491 0.5631 5.1281 3.2628 0.3105 0.2357
15
+ 0.30 6.6191 2.2947 0.5334 4.9780 2.9738 0.3013 0.2200
16
+ 0.25 5.9283 2.1331 0.4961 4.7722 2.6673 0.2922 0.2007
17
+ 0.20 5.1430 1.9641 0.4509 4.5215 2.3198 0.2783 0.1780
18
+ 0.15 4.2498 1.7824 0.3951 4.1916 1.9226 0.2593 0.1498
19
+ 0.10 3.1977 1.5862 0.3183 3.6659 1.4498 0.2278 0.1126
20
+ 0.07 2.4409 1.4496 0.2594 3.1563 1.1179 0.1966 0.0862
21
+ 0.05 1.8696 1.3514 0.2075 2.6620 0.8623 0.1657 0.0655
22
+ arm screen_thin_mono screen_thin_T detect_matched_thin_mono_markers detect_matched_thin_HLA-DRA detect_matched_thin_T_markers detect_matched_thin_NKG7 detect_matched_thin_GZMA
23
+ zs 0.421 0.441 0.518 NaN 0.793 NaN NaN
24
+ xcal 0.799 0.779 0.576 NaN NaN NaN NaN
25
+ r16 0.398 0.601 0.223 0.532 0.623 NaN NaN
26
+ r64 0.376 0.539 0.209 0.437 0.652 NaN NaN
27
+ full20k 0.338 0.619 0.240 0.448 0.684 NaN NaN
28
+ full108k 0.370 0.578 0.293 0.544 0.875 NaN NaN
29
+ s50k 1.000 1.000 0.279 0.574 0.681 NaN NaN
30
+ s162k 1.000 1.000 0.251 0.563 0.700 NaN NaN
31
+ own58 0.823 0.996 0.438 0.562 0.589 NaN 0.89
paper-releases/pbisc-diffusion/updates/20261005T142225Z-rare-states-scratch-vs-pretrained/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/out/scratch_vs_lora_20261005/verify_recompute_cross_report.txt ADDED
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1
+ [sanity] per-donor table reproduces sepsis_loco_summary.csv gen_over_obs and spearman_donors for all 180 rows
2
+ [sanity] vectorised bootstrap Spearman == scipy.spearmanr on checked replicates
3
+ [sanity] contrasts reproduce sepsis_loco_contrasts.csv (obs_diff, gen_diff, same_direction) for all 540 rows
4
+
5
+ === cross-1 ===
6
+ s162k[own] ratio 0.068 ps 0.068 [0.050,0.097] gen 86/20808 obs 6788/111269 (native 6788)
7
+ r16[own] ratio 0.035 ps 0.035 [0.022,0.056] gen 41/22524 obs 5862/111269 (native 6788)
8
+ r64[own] ratio 0.056 ps 0.057 [0.038,0.088] gen 59/20054 obs 5796/111269 (native 6788)
9
+ full20k[own] ratio 0.084 ps 0.085 [0.056,0.127] gen 103/24002 obs 5654/111269 (native 6788)
10
+ full108k[own] ratio 0.093 ps 0.094 [0.063,0.141] gen 94/19494 obs 5757/111269 (native 6788)
11
+ xcal[own] ratio 0.074 ps 0.075 [0.051,0.111] gen 143/32496 obs 6578/111269 (native 6788)
12
+ zs[own] ratio 0.026 ps 0.026 [0.017,0.041] gen 63/45474 obs 5908/111269 (native 6788)
13
+ own5[own] ratio 0.531 ps 0.531 [0.317,0.822] gen 669/21211 obs 6612/111269 (native 6788)
14
+ own58[own] ratio 0.502 ps 0.502 [0.344,0.730] gen 676/22723 obs 6599/111269 (native 6788)
15
+ s162k[depth_r16] ratio 0.078 ps 0.079 [0.057,0.112] gen 86/20808 obs 5862/111269 (native 6788)
16
+ D s162k-r16 [own] C1Q-high monocyte (reference): -0.962 [-1.549,-0.429] (raw-point -0.971) ratios 0.068 vs 0.035 -> scratch_closer
17
+ D s162k-r16 [matched_depth] C1Q-high monocyte (reference): -1.174 [-1.749,-0.651] (raw-point -1.183) ratios 0.078 vs 0.035 -> scratch_closer
18
+ D s162k-r64 [own] C1Q-high monocyte (reference): -0.259 [-0.690,+0.194] (raw-point -0.262) ratios 0.068 vs 0.056 -> ns
19
+ D s162k-r64 [matched_depth] C1Q-high monocyte (reference): -0.487 [-0.915,-0.044] (raw-point -0.490) ratios 0.079 vs 0.056 -> scratch_closer
20
+ D s162k-full108k [own] C1Q-high monocyte (reference): +0.459 [-0.027,+0.923] (raw-point +0.460) ratios 0.068 vs 0.093 -> ns
21
+ D s162k-full108k [matched_depth] C1Q-high monocyte (reference): +0.222 [-0.259,+0.666] (raw-point +0.222) ratios 0.080 vs 0.093 -> ns
22
+ D s162k-xcal [own] C1Q-high monocyte (reference): +0.132 [-0.279,+0.533] (raw-point +0.136) ratios 0.068 vs 0.074 -> ns
23
+ D s162k-xcal [matched_depth] C1Q-high monocyte (reference): -0.079 [-0.496,+0.310] (raw-point -0.076) ratios 0.078 vs 0.074 -> ns
24
+ s162k[own] ratio 0.102 ps 0.102 [0.059,0.159] gen 357/20808 obs 18712/111269 (native 18712)
25
+ r16[own] ratio 0.121 ps 0.121 [0.079,0.184] gen 292/22524 obs 11961/111269 (native 18712)
26
+ r64[own] ratio 0.113 ps 0.113 [0.080,0.166] gen 235/20054 obs 11572/111269 (native 18712)
27
+ full20k[own] ratio 0.292 ps 0.292 [0.188,0.475] gen 679/24002 obs 10777/111269 (native 18712)
28
+ full108k[own] ratio 0.265 ps 0.265 [0.157,0.469] gen 530/19494 obs 11411/111269 (native 18712)
29
+ xcal[own] ratio 0.724 ps 0.724 [0.546,1.045] gen 3632/32496 obs 17185/111269 (native 18712)
30
+ zs[own] ratio 0.080 ps 0.080 [0.056,0.117] gen 403/45474 obs 12363/111269 (native 18712)
31
+ own5[own] ratio 0.644 ps 0.644 [0.214,1.263] gen 2129/21211 obs 17336/111269 (native 18712)
32
+ own58[own] ratio 0.707 ps 0.707 [0.437,1.139] gen 2507/22723 obs 17362/111269 (native 18712)
33
+ s162k[depth_r16] ratio 0.160 ps 0.160 [0.094,0.252] gen 357/20808 obs 11961/111269 (native 18712)
34
+ D s162k-r16 [own] MS1 monocyte (IL1R2+): +0.242 [-0.631,+1.123] (raw-point +0.241) ratios 0.102 vs 0.121 -> ns
35
+ D s162k-r16 [matched_depth] MS1 monocyte (IL1R2+): -0.404 [-1.294,+0.471] (raw-point -0.404) ratios 0.160 vs 0.121 -> ns
36
+ D s162k-r64 [own] MS1 monocyte (IL1R2+): +0.144 [-0.440,+0.864] (raw-point +0.143) ratios 0.102 vs 0.113 -> ns
37
+ D s162k-r64 [matched_depth] MS1 monocyte (IL1R2+): -0.549 [-1.146,+0.159] (raw-point -0.550) ratios 0.165 vs 0.113 -> ns
38
+ D s162k-full108k [own] MS1 monocyte (IL1R2+): +1.377 [+0.510,+2.285] (raw-point +1.378) ratios 0.102 vs 0.265 -> comparator_closer
39
+ D s162k-full108k [matched_depth] MS1 monocyte (IL1R2+): +0.664 [-0.199,+1.464] (raw-point +0.664) ratios 0.167 vs 0.265 -> ns
40
+ D s162k-xcal [own] MS1 monocyte (IL1R2+): +2.825 [+2.224,+3.545] (raw-point +2.826) ratios 0.102 vs 0.724 -> comparator_closer
41
+ D s162k-xcal [matched_depth] MS1 monocyte (IL1R2+): +2.179 [+1.588,+2.892] (raw-point +2.181) ratios 0.160 vs 0.724 -> comparator_closer
42
+ s162k[own] MS1 monocyte (IL1R2+) | adult: gen +1.18 obs +18.97 frac +0.062 same=True
43
+ r16[own] MS1 monocyte (IL1R2+) | adult: gen +1.23 obs +12.51 frac +0.099 same=True
44
+ r64[own] MS1 monocyte (IL1R2+) | adult: gen +0.99 obs +11.87 frac +0.084 same=True
45
+ full20k[own] MS1 monocyte (IL1R2+) | adult: gen +2.51 obs +10.35 frac +0.243 same=True
46
+ full108k[own] MS1 monocyte (IL1R2+) | adult: gen +3.03 obs +11.89 frac +0.255 same=True
47
+ xcal[own] MS1 monocyte (IL1R2+) | adult: gen +8.85 obs +17.53 frac +0.505 same=True
48
+ zs[own] MS1 monocyte (IL1R2+) | adult: gen +0.85 obs +12.73 frac +0.067 same=True
49
+ own5[own] MS1 monocyte (IL1R2+) | adult: gen +4.36 obs +17.78 frac +0.245 same=True
50
+ own58[own] MS1 monocyte (IL1R2+) | adult: gen +10.88 obs +17.50 frac +0.621 same=True
51
+ s162k[depth_r16] MS1 monocyte (IL1R2+) | adult: gen +1.18 obs +12.51 frac +0.095 same=True
52
+ s162k[own] C1Q-high monocyte (reference) | adult: gen +0.25 obs +6.14 frac +0.041 same=True
53
+ s162k[own] C1Q-high monocyte (reference) | paediatric: gen -0.13 obs +9.37 frac -0.014 same=False
54
+ s162k[own] C1Q-high monocyte (reference) | all: gen +0.08 obs +6.91 frac +0.012 same=True
55
+ r16[own] C1Q-high monocyte (reference) | adult: gen -0.24 obs +5.58 frac -0.042 same=False
56
+ r16[own] C1Q-high monocyte (reference) | paediatric: gen -0.05 obs +8.21 frac -0.006 same=False
57
+ r16[own] C1Q-high monocyte (reference) | all: gen -0.08 obs +6.18 frac -0.013 same=False
58
+ r64[own] C1Q-high monocyte (reference) | adult: gen +0.00 obs +5.32 frac +0.001 same=True
59
+ r64[own] C1Q-high monocyte (reference) | paediatric: gen -0.29 obs +8.18 frac -0.035 same=False
60
+ r64[own] C1Q-high monocyte (reference) | all: gen -0.07 obs +5.99 frac -0.011 same=False
61
+ full20k[own] C1Q-high monocyte (reference) | adult: gen -0.13 obs +5.43 frac -0.024 same=False
62
+ full20k[own] C1Q-high monocyte (reference) | paediatric: gen -0.12 obs +7.59 frac -0.016 same=False
63
+ full20k[own] C1Q-high monocyte (reference) | all: gen -0.03 obs +5.88 frac -0.004 same=False
64
+ full108k[own] C1Q-high monocyte (reference) | adult: gen -0.23 obs +5.34 frac -0.043 same=False
65
+ full108k[own] C1Q-high monocyte (reference) | paediatric: gen +0.83 obs +7.83 frac +0.106 same=True
66
+ full108k[own] C1Q-high monocyte (reference) | all: gen +0.13 obs +5.84 frac +0.021 same=True
67
+ xcal[own] C1Q-high monocyte (reference) | adult: gen +0.21 obs +6.05 frac +0.035 same=True
68
+ xcal[own] C1Q-high monocyte (reference) | paediatric: gen +0.14 obs +9.23 frac +0.015 same=True
69
+ xcal[own] C1Q-high monocyte (reference) | all: gen +0.13 obs +6.82 frac +0.019 same=True
70
+ zs[own] C1Q-high monocyte (reference) | adult: gen +0.08 obs +5.45 frac +0.014 same=True
71
+ zs[own] C1Q-high monocyte (reference) | paediatric: gen -0.02 obs +8.48 frac -0.003 same=False
72
+ zs[own] C1Q-high monocyte (reference) | all: gen +0.01 obs +6.12 frac +0.001 same=True
73
+ own5[own] C1Q-high monocyte (reference) | adult: gen -0.47 obs +6.09 frac -0.077 same=False
74
+ own5[own] C1Q-high monocyte (reference) | paediatric: gen +1.36 obs +9.18 frac +0.148 same=True
75
+ own5[own] C1Q-high monocyte (reference) | all: gen +0.40 obs +6.82 frac +0.059 same=True
76
+ own58[own] C1Q-high monocyte (reference) | adult: gen +1.89 obs +6.06 frac +0.312 same=True
77
+ own58[own] C1Q-high monocyte (reference) | paediatric: gen +3.12 obs +9.07 frac +0.344 same=True
78
+ own58[own] C1Q-high monocyte (reference) | all: gen +2.05 obs +6.77 frac +0.302 same=True
79
+
80
+ === cross-2 ===
81
+ s162k[own] ratio 0.049 ps 0.049 [0.027,0.085] gen 35/72018 obs 3461/345949 (native 3461)
82
+ r16[own] ratio 0.151 ps 0.152 [0.092,0.261] gen 76/66367 obs 2628/345949 (native 3461)
83
+ r64[own] ratio 0.172 ps 0.173 [0.107,0.281] gen 76/62886 obs 2433/345949 (native 3461)
84
+ full20k[own] ratio 0.348 ps 0.349 [0.226,0.563] gen 170/64082 obs 2639/345949 (native 3461)
85
+ full108k[own] ratio 0.356 ps 0.357 [0.236,0.563] gen 168/64331 obs 2539/345949 (native 3461)
86
+ xcal[own] ratio 0.458 ps 0.459 [0.298,0.736] gen 280/69407 obs 3048/345949 (native 3461)
87
+ zs[own] ratio 0.830 ps 0.831 [0.565,1.294] gen 294/54913 obs 2232/345949 (native 3461)
88
+ own5[own] ratio 0.288 ps 0.288 [0.190,0.464] gen 211/76200 obs 3331/345949 (native 3461)
89
+ own58[own] ratio 0.536 ps 0.536 [0.346,0.803] gen 405/75578 obs 3461/345949 (native 3461)
90
+ s162k[depth_r16] ratio 0.064 ps 0.065 [0.036,0.111] gen 35/72018 obs 2628/345949 (native 3461)
91
+ s162k[depth_r64] ratio 0.069 ps 0.070 [0.039,0.118] gen 35/72018 obs 2433/345949 (native 3461)
92
+ s162k[depth_full108k] ratio 0.066 ps 0.067 [0.037,0.112] gen 35/72018 obs 2539/345949 (native 3461)
93
+ s162k[depth_full20k] ratio 0.064 ps 0.065 [0.036,0.108] gen 35/72018 obs 2639/345949 (native 3461)
94
+ s162k[depth_xcal] ratio 0.055 ps 0.056 [0.031,0.094] gen 35/72018 obs 3048/345949 (native 3461)
95
+ D s162k-r16 [own] Cycling T/NK: +1.623 [+0.989,+2.314] (raw-point +1.634) ratios 0.049 vs 0.151 -> comparator_closer
96
+ D s162k-r16 [matched_depth] Cycling T/NK: +1.226 [+0.613,+1.907] (raw-point +1.237) ratios 0.064 vs 0.151 -> comparator_closer
97
+ D s162k-r64 [own] Cycling T/NK: +1.812 [+1.279,+2.428] (raw-point +1.823) ratios 0.049 vs 0.172 -> comparator_closer
98
+ D s162k-r64 [matched_depth] Cycling T/NK: +1.303 [+0.797,+1.897] (raw-point +1.314) ratios 0.069 vs 0.172 -> comparator_closer
99
+ D s162k-full108k [own] Cycling T/NK: +2.857 [+2.271,+3.595] (raw-point +2.873) ratios 0.049 vs 0.356 -> comparator_closer
100
+ D s162k-full108k [matched_depth] Cycling T/NK: +2.410 [+1.829,+3.139] (raw-point +2.426) ratios 0.066 vs 0.356 -> comparator_closer
101
+ D s162k-xcal [own] Cycling T/NK: +3.219 [+2.718,+3.860] (raw-point +3.237) ratios 0.049 vs 0.458 -> comparator_closer
102
+ D s162k-xcal [matched_depth] Cycling T/NK: +2.822 [+2.318,+3.458] (raw-point +2.839) ratios 0.064 vs 0.458 -> comparator_closer
103
+ D s162k-xcal [matched_depth_xcalref] Cycling T/NK: +3.035 [+2.535,+3.672] (raw-point +3.053) ratios 0.055 vs 0.458 -> comparator_closer
104
+ D s162k-full20k [own] Cycling T/NK: +2.823 [+2.208,+3.562] (raw-point +2.840) ratios 0.049 vs 0.348 -> comparator_closer
105
+ D s162k-full20k [matched_depth] Cycling T/NK: +2.432 [+1.809,+3.172] (raw-point +2.449) ratios 0.064 vs 0.348 -> comparator_closer
106
+ s162k[own] ratio 0.024 ps 0.025 [0.013,0.042] gen 21/20808 obs 4601/111269 (native 4601)
107
+ r16[own] ratio 0.062 ps 0.063 [0.035,0.113] gen 32/22524 obs 2531/111269 (native 4601)
108
+ r64[own] ratio 0.070 ps 0.071 [0.045,0.118] gen 31/20054 obs 2455/111269 (native 4601)
109
+ full20k[own] ratio 0.150 ps 0.151 [0.101,0.241] gen 73/24002 obs 2253/111269 (native 4601)
110
+ full108k[own] ratio 0.114 ps 0.115 [0.075,0.178] gen 48/19494 obs 2398/111269 (native 4601)
111
+ xcal[own] ratio 0.252 ps 0.253 [0.161,0.397] gen 293/32496 obs 3975/111269 (native 4601)
112
+ zs[own] ratio 0.096 ps 0.097 [0.061,0.160] gen 103/45474 obs 2618/111269 (native 4601)
113
+ own5[own] ratio 0.304 ps 0.305 [0.078,0.688] gen 235/21211 obs 4056/111269 (native 4601)
114
+ own58[own] ratio 0.228 ps 0.229 [0.088,0.508] gen 189/22723 obs 4056/111269 (native 4601)
115
+ s162k[depth_r16] ratio 0.044 ps 0.045 [0.023,0.080] gen 21/20808 obs 2531/111269 (native 4601)
116
+ s162k[depth_r64] ratio 0.046 ps 0.047 [0.024,0.083] gen 21/20808 obs 2455/111269 (native 4601)
117
+ s162k[depth_full108k] ratio 0.047 ps 0.048 [0.025,0.086] gen 21/20808 obs 2398/111269 (native 4601)
118
+ s162k[depth_full20k] ratio 0.050 ps 0.051 [0.026,0.092] gen 21/20808 obs 2253/111269 (native 4601)
119
+ s162k[depth_xcal] ratio 0.028 ps 0.029 [0.015,0.049] gen 21/20808 obs 3975/111269 (native 4601)
120
+ D s162k-r16 [own] Cycling monocyte (Ye 2026): +1.344 [+0.478,+2.253] (raw-point +1.356) ratios 0.024 vs 0.062 -> comparator_closer
121
+ D s162k-r16 [matched_depth] Cycling monocyte (Ye 2026): +0.482 [-0.386,+1.362] (raw-point +0.493) ratios 0.044 vs 0.062 -> ns
122
+ D s162k-r64 [own] Cycling monocyte (Ye 2026): +1.510 [+0.771,+2.366] (raw-point +1.521) ratios 0.024 vs 0.070 -> comparator_closer
123
+ D s162k-r64 [matched_depth] Cycling monocyte (Ye 2026): +0.604 [-0.152,+1.446] (raw-point +0.615) ratios 0.046 vs 0.070 -> ns
124
+ D s162k-full108k [own] Cycling monocyte (Ye 2026): +2.208 [+1.352,+3.128] (raw-point +2.227) ratios 0.024 vs 0.114 -> comparator_closer
125
+ D s162k-full108k [matched_depth] Cycling monocyte (Ye 2026): +1.268 [+0.413,+2.199] (raw-point +1.287) ratios 0.047 vs 0.114 -> comparator_closer
126
+ D s162k-xcal [own] Cycling monocyte (Ye 2026): +3.339 [+2.556,+4.172] (raw-point +3.370) ratios 0.024 vs 0.252 -> comparator_closer
127
+ D s162k-xcal [matched_depth] Cycling monocyte (Ye 2026): +2.477 [+1.652,+3.334] (raw-point +2.508) ratios 0.044 vs 0.252 -> comparator_closer
128
+ D s162k-xcal [matched_depth_xcalref] Cycling monocyte (Ye 2026): +3.128 [+2.339,+3.967] (raw-point +3.159) ratios 0.028 vs 0.252 -> comparator_closer
129
+ D s162k-full20k [own] Cycling monocyte (Ye 2026): +2.597 [+1.852,+3.433] (raw-point +2.622) ratios 0.024 vs 0.150 -> comparator_closer
130
+ D s162k-full20k [matched_depth] Cycling monocyte (Ye 2026): +1.567 [+0.795,+2.425] (raw-point +1.591) ratios 0.050 vs 0.150 -> comparator_closer
131
+ s162k[own] ratio 0.051 ps 0.052 [0.032,0.077] gen 56/55309 obs 5877/298117 (native 5877)
132
+ r16[own] ratio 0.098 ps 0.099 [0.064,0.155] gen 69/51586 obs 4069/298117 (native 5877)
133
+ r64[own] ratio 0.140 ps 0.141 [0.090,0.221] gen 83/47130 obs 3740/298117 (native 5877)
134
+ full20k[own] ratio 0.207 ps 0.208 [0.143,0.306] gen 142/49480 obs 4135/298117 (native 5877)
135
+ full108k[own] ratio 0.227 ps 0.228 [0.155,0.342] gen 143/47593 obs 3950/298117 (native 5877)
136
+ xcal[own] ratio 0.245 ps 0.246 [0.165,0.372] gen 230/57613 obs 4851/298117 (native 5877)
137
+ zs[own] ratio 0.361 ps 0.362 [0.244,0.560] gen 168/43347 obs 3198/298117 (native 5877)
138
+ own5[own] ratio 0.157 ps 0.157 [0.109,0.230] gen 205/71032 obs 5478/298117 (native 5877)
139
+ own58[own] ratio 0.297 ps 0.297 [0.192,0.441] gen 396/67850 obs 5860/298117 (native 5877)
140
+ s162k[depth_r16] ratio 0.074 ps 0.075 [0.047,0.112] gen 56/55309 obs 4069/298117 (native 5877)
141
+ s162k[depth_r64] ratio 0.081 ps 0.081 [0.051,0.123] gen 56/55309 obs 3740/298117 (native 5877)
142
+ s162k[depth_full108k] ratio 0.076 ps 0.077 [0.048,0.116] gen 56/55309 obs 3950/298117 (native 5877)
143
+ s162k[depth_full20k] ratio 0.073 ps 0.074 [0.046,0.111] gen 56/55309 obs 4135/298117 (native 5877)
144
+ s162k[depth_xcal] ratio 0.062 ps 0.063 [0.039,0.094] gen 56/55309 obs 4851/298117 (native 5877)
145
+ D s162k-r16 [own] Cycling activated T (CD38/HLA-DR): +0.930 [+0.438,+1.501] (raw-point +0.932) ratios 0.051 vs 0.098 -> comparator_closer
146
+ D s162k-r16 [matched_depth] Cycling activated T (CD38/HLA-DR): +0.399 [-0.077,+0.966] (raw-point +0.402) ratios 0.074 vs 0.098 -> ns
147
+ D s162k-r64 [own] Cycling activated T (CD38/HLA-DR): +1.446 [+1.013,+1.934] (raw-point +1.451) ratios 0.051 vs 0.140 -> comparator_closer
148
+ D s162k-r64 [matched_depth] Cycling activated T (CD38/HLA-DR): +0.794 [+0.358,+1.278] (raw-point +0.799) ratios 0.081 vs 0.140 -> comparator_closer
149
+ D s162k-full108k [own] Cycling activated T (CD38/HLA-DR): +2.135 [+1.625,+2.784] (raw-point +2.143) ratios 0.051 vs 0.227 -> comparator_closer
150
+ D s162k-full108k [matched_depth] Cycling activated T (CD38/HLA-DR): +1.561 [+1.059,+2.187] (raw-point +1.569) ratios 0.076 vs 0.227 -> comparator_closer
151
+ D s162k-xcal [own] Cycling activated T (CD38/HLA-DR): +2.246 [+1.761,+2.811] (raw-point +2.256) ratios 0.051 vs 0.245 -> comparator_closer
152
+ D s162k-xcal [matched_depth] Cycling activated T (CD38/HLA-DR): +1.716 [+1.223,+2.271] (raw-point +1.726) ratios 0.074 vs 0.245 -> comparator_closer
153
+ D s162k-xcal [matched_depth_xcalref] Cycling activated T (CD38/HLA-DR): +1.970 [+1.483,+2.533] (raw-point +1.979) ratios 0.062 vs 0.245 -> comparator_closer
154
+ D s162k-full20k [own] Cycling activated T (CD38/HLA-DR): +2.002 [+1.516,+2.622] (raw-point +2.010) ratios 0.051 vs 0.207 -> comparator_closer
155
+ D s162k-full20k [matched_depth] Cycling activated T (CD38/HLA-DR): +1.495 [+1.006,+2.111] (raw-point +1.503) ratios 0.073 vs 0.207 -> comparator_closer
156
+ s162k[own] ratio 0.532 ps 0.532 [0.377,0.807] gen 473/55309 obs 4793/298117 (native 4793)
157
+ r16[own] ratio 0.789 ps 0.789 [0.554,1.179] gen 654/51586 obs 4793/298117 (native 4793)
158
+ r64[own] ratio 1.037 ps 1.038 [0.752,1.547] gen 786/47130 obs 4793/298117 (native 4793)
159
+ full20k[own] ratio 1.084 ps 1.084 [0.774,1.632] gen 862/49480 obs 4793/298117 (native 4793)
160
+ full108k[own] ratio 1.127 ps 1.127 [0.801,1.696] gen 862/47593 obs 4793/298117 (native 4793)
161
+ xcal[own] ratio 0.642 ps 0.643 [0.441,0.988] gen 595/57613 obs 4793/298117 (native 4793)
162
+ zs[own] ratio 1.964 ps 1.965 [1.353,3.015] gen 1369/43347 obs 4793/298117 (native 4793)
163
+ own5[own] ratio 0.616 ps 0.616 [0.446,0.916] gen 703/71032 obs 4793/298117 (native 4793)
164
+ own58[own] ratio 0.776 ps 0.776 [0.545,1.094] gen 846/67850 obs 4793/298117 (native 4793)
165
+ s162k[depth_r16] ratio 0.532 ps 0.532 [0.377,0.807] gen 473/55309 obs 4793/298117 (native 4793)
166
+ s162k[depth_r64] ratio 0.532 ps 0.532 [0.377,0.807] gen 473/55309 obs 4793/298117 (native 4793)
167
+ s162k[depth_full108k] ratio 0.532 ps 0.532 [0.377,0.807] gen 473/55309 obs 4793/298117 (native 4793)
168
+ s162k[depth_full20k] ratio 0.532 ps 0.532 [0.377,0.807] gen 473/55309 obs 4793/298117 (native 4793)
169
+ s162k[depth_xcal] ratio 0.532 ps 0.532 [0.377,0.807] gen 473/55309 obs 4793/298117 (native 4793)
170
+ D s162k-r16 [own] Proliferating T (label): +0.568 [+0.093,+0.795] (raw-point +0.568) ratios 0.532 vs 0.789 -> comparator_closer
171
+ D s162k-r16 [matched_depth] Proliferating T (label): +0.568 [+0.093,+0.795] (raw-point +0.568) ratios 0.532 vs 0.789 -> comparator_closer
172
+ D s162k-r64 [own] Proliferating T (label): +0.856 [-0.296,+1.132] (raw-point +0.858) ratios 0.532 vs 1.037 -> ns
173
+ D s162k-r64 [matched_depth] Proliferating T (label): +0.856 [-0.296,+1.132] (raw-point +0.858) ratios 0.532 vs 1.037 -> ns
174
+ D s162k-full108k [own] Proliferating T (label): +0.737 [-0.410,+1.219] (raw-point +0.739) ratios 0.532 vs 1.127 -> ns
175
+ D s162k-full108k [matched_depth] Proliferating T (label): +0.737 [-0.410,+1.219] (raw-point +0.739) ratios 0.532 vs 1.127 -> ns
176
+ D s162k-xcal [own] Proliferating T (label): +0.272 [-0.044,+0.519] (raw-point +0.272) ratios 0.532 vs 0.642 -> ns
177
+ D s162k-xcal [matched_depth] Proliferating T (label): +0.272 [-0.044,+0.519] (raw-point +0.272) ratios 0.532 vs 0.642 -> ns
178
+ D s162k-xcal [matched_depth_xcalref] Proliferating T (label): +0.272 [-0.044,+0.519] (raw-point +0.272) ratios 0.532 vs 0.642 -> ns
179
+ D s162k-full20k [own] Proliferating T (label): +0.793 [-0.358,+1.163] (raw-point +0.795) ratios 0.532 vs 1.084 -> ns
180
+ D s162k-full20k [matched_depth] Proliferating T (label): +0.793 [-0.358,+1.163] (raw-point +0.795) ratios 0.532 vs 1.084 -> ns
181
+
182
+ === cross-3 ===
183
+ name variant value ci_lo ci_hi n_within_2fold mean_abs_log2_rawpoint
184
+ zs own 1.824472 1.663195 2.012619 5.0 1.827941
185
+ xcal own 1.533027 1.335047 1.756932 5.0 1.534476
186
+ r16 own 2.315477 2.121963 2.536914 6.0 2.323521
187
+ r64 own 2.209743 2.060764 2.441715 5.0 2.216475
188
+ full20k own 1.749165 1.602299 1.952253 6.0 1.753622
189
+ full108k own 1.923088 1.741579 2.140157 3.0 1.927780
190
+ s50k own 2.326924 2.120093 2.596406 3.0 2.331880
191
+ s50k depth_r16 1.929241 1.751993 2.201295 3.0 1.933504
192
+ s100k own 2.494955 2.273215 2.790713 4.0 2.500809
193
+ s100k depth_r16 2.101785 1.905756 2.396662 4.0 2.107616
194
+ s150k own 2.560493 2.346660 2.823852 5.0 2.567898
195
+ s150k depth_r16 2.157506 1.973879 2.428574 6.0 2.164450
196
+ s162k own 2.615088 2.427892 2.865344 5.0 2.623034
197
+ s162k depth_r16 2.208989 2.052973 2.474890 6.0 2.216504
198
+ own5 own 1.535011 1.261095 1.923235 5.0 1.537102
199
+ own58 own 1.286695 1.048667 1.610318 7.0 1.288725
200
+ name variant value ci_lo ci_hi
201
+ s162k vs r16 own 0.299611 0.092872 0.519740
202
+ s162k vs r16 matched_depth -0.106488 -0.242692 0.112003
203
+ s162k vs r64 own 0.405346 0.170583 0.618411
204
+ s162k vs r64 matched_depth -0.044243 -0.207531 0.130701
205
+ s162k vs full108k own 0.692000 0.416618 1.000177
206
+ s162k vs full108k matched_depth 0.245309 0.029853 0.538881
207
+ s162k vs xcal own 1.082061 0.920058 1.289102
208
+ s162k vs xcal matched_depth 0.675962 0.551143 0.891117
209
+ s162k vs xcal matched_depth_xcalref 0.951388 0.798703 1.160382
210
+ s162k vs full20k own 0.865924 0.616000 1.103578
211
+ s162k vs full20k matched_depth 0.413358 0.226864 0.649958
212
+ s162k vs zs own 0.790617 0.563634 1.049415
213
+ s162k vs zs matched_depth 0.349621 0.145297 0.588842
214
+ s50k vs r16 own 0.011447 -0.191671 0.244829
215
+ s50k vs r16 matched_depth -0.386236 -0.540089 -0.173101
216
+ s50k vs r64 own 0.117182 -0.107330 0.328783
217
+ s50k vs r64 matched_depth -0.327884 -0.490628 -0.167552
218
+ s50k vs full108k own 0.403836 0.145144 0.705218
219
+ s50k vs full108k matched_depth -0.035045 -0.240258 0.243121
220
+ s50k vs xcal own 0.793897 0.642958 0.991987
221
+ s50k vs xcal matched_depth 0.396214 0.273077 0.595440
222
+ s50k vs xcal matched_depth_xcalref 0.654116 0.530591 0.862914
223
+ s162k vs s50k own 0.288164 0.153021 0.424933
224
+ s162k vs s50k both_at_r16_depth 0.279748 0.155550 0.422547
225
+ s162k vs s100k own 0.120133 -0.010789 0.242071
226
+ s162k vs s100k both_at_r16_depth 0.107204 -0.016626 0.242179
227
+ s162k vs s150k own 0.054595 -0.061029 0.171858
228
+ s162k vs s150k both_at_r16_depth 0.051483 -0.059479 0.171470
229
+ s162k vs own58 own 1.328393 1.036540 1.592187
230
+ s162k vs own5 own 1.080078 0.711299 1.374980
231
+ verdict comparator_closer ns scratch_closer
232
+ comparison variant
233
+ s162k vs full108k matched_depth 3 7 3
234
+ own 6 5 2
235
+ s162k vs full20k matched_depth 3 10 0
236
+ own 6 7 0
237
+ s162k vs own5 own 7 4 2
238
+ s162k vs own58 own 8 4 1
239
+ s162k vs r16 matched_depth 3 7 3
240
+ own 5 7 1
241
+ s162k vs r64 matched_depth 2 7 4
242
+ own 4 8 1
243
+ s162k vs s100k both_at_r16_depth 3 8 2
244
+ own 3 8 2
245
+ s162k vs s150k both_at_r16_depth 2 11 0
246
+ own 2 11 0
247
+ s162k vs s50k both_at_r16_depth 5 5 3
248
+ own 5 5 3
249
+ s162k vs xcal matched_depth 5 6 2
250
+ matched_depth_xcalref 6 6 1
251
+ own 6 6 1
252
+ s162k vs zs matched_depth 5 3 5
253
+ own 5 5 3
254
+ s50k vs full108k matched_depth 2 9 2
255
+ own 5 6 2
256
+ s50k vs r16 matched_depth 3 5 5
257
+ own 3 8 2
258
+ s50k vs r64 matched_depth 3 3 7
259
+ own 4 6 3
260
+ s50k vs xcal matched_depth 6 4 3
261
+ matched_depth_xcalref 8 3 2
262
+ own 9 3 1
263
+ s162k vs r16 [own] scratch_closer: ['C1Q-high monocyte (reference)'] | comparator_closer: ['Cycling T/NK', 'Cycling activated T (CD38/HLA-DR)', 'Proliferating T (label)', 'Plasmablast (markers)', 'Cycling monocyte (Ye 2026)']
264
+ s162k vs r16 [matched_depth] scratch_closer: ['C1Q-high monocyte (reference)', 'DN2 / ABC B', 'Granulocyte-like (LDG)'] | comparator_closer: ['Cycling T/NK', 'Proliferating T (label)', 'Plasmablast (markers)']
265
+ s162k vs r64 [own] scratch_closer: ['HSPC'] | comparator_closer: ['Cycling T/NK', 'Cycling activated T (CD38/HLA-DR)', 'Plasmablast (markers)', 'Cycling monocyte (Ye 2026)']
266
+ s162k vs r64 [matched_depth] scratch_closer: ['C1Q-high monocyte (reference)', 'DN2 / ABC B', 'HSPC', 'Cytotoxic CD4 T'] | comparator_closer: ['Cycling T/NK', 'Cycling activated T (CD38/HLA-DR)']
267
+ s162k vs full108k [own] scratch_closer: ['Plasmablast (label)', 'HSPC'] | comparator_closer: ['Cycling T/NK', 'Cycling activated T (CD38/HLA-DR)', 'Plasmablast (markers)', 'MS1 monocyte (IL1R2+)', 'Cycling monocyte (Ye 2026)', 'DN2 / ABC B']
268
+ s162k vs full108k [matched_depth] scratch_closer: ['Plasmablast (label)', 'HSPC', 'Cytotoxic CD4 T'] | comparator_closer: ['Cycling T/NK', 'Cycling activated T (CD38/HLA-DR)', 'Cycling monocyte (Ye 2026)']
269
+ s162k vs xcal [own] scratch_closer: ['Cytotoxic CD4 T'] | comparator_closer: ['Cycling T/NK', 'Cycling activated T (CD38/HLA-DR)', 'MS1 monocyte (IL1R2+)', 'Cycling monocyte (Ye 2026)', 'DN2 / ABC B', 'Granulocyte-like (LDG)']
270
+ s162k vs xcal [matched_depth] scratch_closer: ['Plasmablast (markers)', 'Cytotoxic CD4 T'] | comparator_closer: ['Cycling T/NK', 'Cycling activated T (CD38/HLA-DR)', 'MS1 monocyte (IL1R2+)', 'Cycling monocyte (Ye 2026)', 'Granulocyte-like (LDG)']
271
+ s162k vs xcal [matched_depth_xcalref] scratch_closer: ['Cytotoxic CD4 T'] | comparator_closer: ['Cycling T/NK', 'Cycling activated T (CD38/HLA-DR)', 'MS1 monocyte (IL1R2+)', 'Cycling monocyte (Ye 2026)', 'DN2 / ABC B', 'Granulocyte-like (LDG)']
272
+ s162k vs full20k [own] scratch_closer: [] | comparator_closer: ['Cycling T/NK', 'Cycling activated T (CD38/HLA-DR)', 'Plasmablast (markers)', 'MS1 monocyte (IL1R2+)', 'Cycling monocyte (Ye 2026)', 'DN2 / ABC B']
273
+ s162k vs full20k [matched_depth] scratch_closer: [] | comparator_closer: ['Cycling T/NK', 'Cycling activated T (CD38/HLA-DR)', 'Cycling monocyte (Ye 2026)']
274
+
275
+ === cross-4 ===
276
+ arm parent n_parent median_lib_all_cells median_lib_parent mean_detected_markers_of_73 umis_per_detected_marker det_HLA-DRA det_NKG7 det_GZMA screen_thin implied_obs_median_lib_parent
277
+ zs Monocyte 45474 973.0 1187.0 8.8998 3.4254 0.7515 0.1646 0.0254 0.421 2819.4774
278
+ zs T cell+NK cell 54913 973.0 787.0 6.0405 5.6880 0.0657 0.6102 0.4892 0.419 1878.2816
279
+ zs T cell 43347 973.0 874.0 5.0621 4.9266 0.0720 0.5170 0.4074 0.441 1981.8594
280
+ zs ALL 123000 973.0 973.0 6.8307 5.2406 0.4648 0.3458 0.2299 0.495 1965.6566
281
+ zs B cell 18316 973.0 1111.0 4.4247 10.6322 0.9680 0.0511 0.0093 0.575 1932.1739
282
+ zs Naive CD4 T cell+Memory CD4 T cell+Treg 15654 973.0 1400.0 2.1842 1.9695 0.0395 0.1097 0.0287 0.619 2261.7124
283
+ xcal Monocyte 32496 1628.0 2255.0 9.3781 3.2217 0.7957 0.3409 0.0489 0.799 2822.2778
284
+ xcal T cell+NK cell 69407 1628.0 1444.0 6.8861 7.2591 0.1280 0.7012 0.6385 0.769 1877.7633
285
+ xcal T cell 57613 1628.0 1543.0 6.2241 6.1915 0.1378 0.6425 0.5825 0.779 1980.7445
286
+ xcal ALL 123000 1628.0 1628.0 7.2555 6.1322 0.4303 0.4993 0.3754 0.828 1966.1836
287
+ xcal B cell 17472 1628.0 1907.0 4.9809 9.8159 0.9452 0.0437 0.0085 0.987 1932.1175
288
+ xcal Naive CD4 T cell+Memory CD4 T cell+Treg 15566 1628.0 2078.0 2.6017 2.2018 0.0848 0.0922 0.0738 0.919 2261.1534
289
+ r16 Monocyte 22524 1135.0 1123.0 5.5006 2.6667 0.6405 0.1432 0.0122 0.398 2821.6080
290
+ r16 T cell+NK cell 66367 1135.0 1082.0 5.4777 5.3931 0.0567 0.6151 0.5254 0.576 1878.4722
291
+ r16 T cell 51586 1135.0 1190.0 4.4784 4.1802 0.0586 0.5081 0.4287 0.601 1980.0333
292
+ r16 ALL 123000 1135.0 1135.0 5.3125 5.2293 0.3916 0.3736 0.2875 0.577 1967.0711
293
+ r16 B cell 28860 1135.0 1248.0 4.6591 6.4014 0.9217 0.0392 0.0059 0.646 1931.8885
294
+ r16 Naive CD4 T cell+Memory CD4 T cell+Treg 18454 1135.0 1563.0 1.9654 2.0618 0.0345 0.0587 0.0604 0.691 2261.9392
295
+ r64 Monocyte 20054 1013.0 1061.0 5.2905 2.5357 0.6044 0.1136 0.0103 0.376 2821.8085
296
+ r64 T cell+NK cell 62886 1013.0 968.0 5.6288 5.2949 0.0597 0.6185 0.5252 0.516 1875.9690
297
+ r64 T cell 47130 1013.0 1067.0 4.5805 4.1807 0.0663 0.4964 0.4230 0.539 1979.5918
298
+ r64 ALL 123000 1013.0 1013.0 5.2142 5.3077 0.4208 0.3505 0.2721 0.515 1966.9903
299
+ r64 B cell 33758 1013.0 1046.0 4.2678 6.3965 0.9328 0.0328 0.0053 0.541 1933.4566
300
+ r64 Naive CD4 T cell+Memory CD4 T cell+Treg 17818 1013.0 1406.0 1.9404 2.0764 0.0365 0.0485 0.0580 0.622 2260.4502
301
+ full20k Monocyte 24002 1070.0 954.0 5.7742 2.5957 0.6093 0.1985 0.0236 0.338 2822.4852
302
+ full20k T cell+NK cell 64082 1070.0 1070.0 5.6480 5.9044 0.0768 0.6166 0.5177 0.570 1877.1930
303
+ full20k T cell 49480 1070.0 1226.0 4.6963 4.5965 0.0802 0.5078 0.4211 0.619 1980.6139
304
+ full20k ALL 123000 1070.0 1070.0 5.5352 5.8621 0.4077 0.3820 0.2778 0.544 1966.9118
305
+ full20k B cell 30208 1070.0 1153.0 5.0560 8.4772 0.9089 0.0537 0.0107 0.596 1934.5638
306
+ full20k Naive CD4 T cell+Memory CD4 T cell+Treg 18475 1070.0 1770.0 2.1430 2.1914 0.0390 0.0665 0.0657 0.782 2263.4271
307
+ full108k Monocyte 19494 1055.0 1043.0 6.5252 2.6995 0.6446 0.2448 0.0220 0.370 2818.9189
308
+ full108k T cell+NK cell 64331 1055.0 1024.0 6.4476 5.8311 0.0803 0.6649 0.5483 0.546 1875.4579
309
+ full108k T cell 47593 1055.0 1146.0 5.3040 4.5447 0.0860 0.5498 0.4388 0.578 1982.6990
310
+ full108k ALL 123000 1055.0 1055.0 6.1582 5.9529 0.4257 0.4167 0.2931 0.536 1968.2836
311
+ full108k B cell 33880 1055.0 1096.0 5.3151 8.1924 0.9002 0.0744 0.0076 0.567 1932.9806
312
+ full108k Naive CD4 T cell+Memory CD4 T cell+Treg 15734 1055.0 1560.0 2.4662 2.1531 0.0423 0.0803 0.0614 0.690 2260.8696
313
+ s50k Monocyte 22424 13891.0 13373.0 6.3344 3.0888 0.6547 0.1279 0.0059 1.000 NaN
314
+ s50k T cell+NK cell 74248 13891.0 13939.0 6.0564 7.1520 0.0755 0.6176 0.5457 1.000 NaN
315
+ s50k T cell 55016 13891.0 14115.0 4.6869 5.2623 0.0771 0.4857 0.4226 1.000 NaN
316
+ s50k ALL 123000 13891.0 13891.0 5.7978 6.9361 0.3626 0.4054 0.3311 1.000 NaN
317
+ s50k B cell 22935 13891.0 14355.0 4.3294 9.9386 0.9667 0.0337 0.0024 1.000 NaN
318
+ s50k Naive CD4 T cell+Memory CD4 T cell+Treg 21052 13891.0 14040.5 1.8314 2.1163 0.0284 0.0478 0.0493 1.000 NaN
319
+ s100k Monocyte 22868 19138.0 18579.0 5.9070 2.9078 0.6590 0.1455 0.0090 1.000 NaN
320
+ s100k T cell+NK cell 70677 19138.0 19068.0 5.8176 6.8658 0.0810 0.6151 0.5262 1.000 NaN
321
+ s100k T cell 53046 19138.0 19185.0 4.5509 4.9898 0.0856 0.4890 0.4119 1.000 NaN
322
+ s100k ALL 123000 19138.0 19138.0 5.5537 6.8406 0.3867 0.3944 0.3048 1.000 NaN
323
+ s100k B cell 24584 19138.0 20102.0 4.3133 10.2522 0.9548 0.0438 0.0026 1.000 NaN
324
+ s100k Naive CD4 T cell+Memory CD4 T cell+Treg 20421 19138.0 18867.0 1.8197 2.1014 0.0338 0.0538 0.0499 1.000 NaN
325
+ s150k Monocyte 24718 20524.0 20053.5 6.0361 2.8827 0.6759 0.1549 0.0098 1.000 NaN
326
+ s150k T cell+NK cell 67979 20524.0 20452.0 5.9594 6.7664 0.0796 0.6177 0.5370 1.000 NaN
327
+ s150k T cell 51762 20524.0 20614.0 4.7214 4.9345 0.0827 0.4998 0.4303 1.000 NaN
328
+ s150k ALL 123000 20524.0 20524.0 5.6127 6.4818 0.4029 0.3864 0.2998 1.000 NaN
329
+ s150k B cell 26415 20524.0 21365.0 4.2560 9.1426 0.9454 0.0440 0.0035 1.000 NaN
330
+ s150k Naive CD4 T cell+Memory CD4 T cell+Treg 19128 20524.0 20509.5 1.8419 2.1210 0.0387 0.0513 0.0605 1.000 NaN
331
+ s162k Monocyte 20808 20606.0 20300.5 5.9421 2.7890 0.6510 0.1533 0.0087 1.000 NaN
332
+ s162k T cell+NK cell 72018 20606.0 20466.5 5.9509 6.7218 0.0741 0.6149 0.5351 1.000 NaN
333
+ s162k T cell 55309 20606.0 20605.0 4.7559 4.9479 0.0766 0.5003 0.4308 1.000 NaN
334
+ s162k ALL 123000 20606.0 20606.0 5.6025 6.7201 0.3751 0.3985 0.3157 1.000 NaN
335
+ s162k B cell 26655 20606.0 21460.0 4.3284 10.0646 0.9410 0.0403 0.0027 1.000 NaN
336
+ s162k Naive CD4 T cell+Memory CD4 T cell+Treg 20606 20606.0 20458.0 1.8742 2.1112 0.0330 0.0540 0.0590 1.000 NaN
337
+ own5 Monocyte 21211 1786.0 2317.0 8.1665 3.2288 0.6223 0.3104 0.0251 0.821 2822.1681
338
+ own5 T cell+NK cell 76200 1786.0 1744.0 4.1638 4.9160 0.0908 0.3681 0.3007 0.929 1877.2874
339
+ own5 T cell 71032 1786.0 1811.0 3.7708 4.3451 0.0896 0.3237 0.2644 0.914 1981.4004
340
+ own5 ALL 123000 1786.0 1786.0 4.9456 5.4536 0.3403 0.2887 0.1922 0.908 1966.9604
341
+ own5 B cell 21371 1786.0 1769.0 4.4053 9.1777 0.9709 0.0159 0.0061 0.915 1933.3333
342
+ own5 Naive CD4 T cell+Memory CD4 T cell+Treg 33233 1786.0 2147.0 2.1066 2.3078 0.0444 0.0491 0.0467 0.949 2262.3815
343
+ own58 Monocyte 22723 1882.0 2321.0 8.1723 3.0975 0.6505 0.3019 0.0379 0.823 2820.1701
344
+ own58 T cell+NK cell 75578 1882.0 1878.0 4.9774 5.4142 0.0991 0.4332 0.3724 1.000 NaN
345
+ own58 T cell 67850 1882.0 1973.0 4.3489 4.4606 0.0957 0.3701 0.3151 0.996 1980.9237
346
+ own58 ALL 123000 1882.0 1882.0 5.5493 5.9280 0.3437 0.3293 0.2378 0.957 1966.5622
347
+ own58 B cell 19896 1882.0 1805.0 4.7667 10.6602 0.9487 0.0194 0.0089 0.934 1932.5482
348
+ own58 Naive CD4 T cell+Memory CD4 T cell+Treg 30246 1882.0 2342.0 2.3979 2.3493 0.0459 0.0593 0.0610 1.000 NaN
349
+ arm median_lib_all_cells bench_umi_gen bench_umi_obs bench_detected_gen bench_detected_obs bench_precision bench_coverage
350
+ zs 973.0 979.0 1967.0 340.0 411.0 0.616992 0.073984
351
+ xcal 1628.0 1628.0 1967.0 269.0 411.0 0.896098 0.463821
352
+ r16 1135.0 1135.0 1967.0 243.0 411.0 0.861138 0.341382
353
+ r64 1013.0 1013.0 1967.0 232.0 411.0 0.828130 0.289187
354
+ full20k 1070.0 1070.0 1967.0 224.0 411.0 0.837642 0.329268
355
+ full108k 1055.0 1055.0 1967.0 232.0 411.0 0.820813 0.345691
356
+ s50k 13891.0 13891.0 1967.0 234.0 411.0 0.999350 0.062602
357
+ s100k 19138.0 19138.0 1967.0 233.0 411.0 0.999837 0.037073
358
+ s150k 20524.0 20524.0 1967.0 237.0 411.0 0.999593 0.033984
359
+ s162k 20606.0 20606.0 1967.0 236.0 411.0 0.999756 0.031789
360
+ own5 1786.0 NaN NaN NaN NaN NaN NaN
361
+ own58 1882.0 NaN NaN NaN NaN NaN NaN
362
+ pretrained (r16/r64/full20k/full108k) thin range over marker states: 0.338 0.782
363
+ pretrained thin range over monocyte+T parents (C1Q, cycling T/NK, ISG-high T): 0.338 0.619
364
+ scratch thin values: [1.0]
365
+ C1Q-high monocyte (reference) s162k own 0.068 | at depth r16 0.078 r64 0.079 full20k 0.081 full108k 0.080 | factor r16/own 1.158
366
+ Cycling T/NK s162k own 0.049 | at depth r16 0.064 r64 0.069 full20k 0.064 full108k 0.066 | factor r16/own 1.317
367
+ Cycling activated T (CD38/HLA-DR) s162k own 0.051 | at depth r16 0.074 r64 0.081 full20k 0.073 full108k 0.076 | factor r16/own 1.444
368
+ Plasmablast (markers) s162k own 0.338 | at depth r16 0.530 r64 0.578 full20k 0.555 full108k 0.561 | factor r16/own 1.566
369
+ MS1 monocyte (IL1R2+) s162k own 0.102 | at depth r16 0.160 r64 0.165 full20k 0.177 full108k 0.167 | factor r16/own 1.564
370
+ Cycling monocyte (Ye 2026) s162k own 0.024 | at depth r16 0.044 r64 0.046 full20k 0.050 full108k 0.047 | factor r16/own 1.818
371
+ ISG-high monocyte (positive control) s162k own 0.473 | at depth r16 0.952 r64 1.000 full20k 1.096 full108k 1.017 | factor r16/own 2.014
372
+ ISG-high T s162k own 0.599 | at depth r16 1.001 r64 1.141 full20k 0.978 full108k 1.062 | factor r16/own 1.671
373
+ DN2 / ABC B s162k own 0.163 | at depth r16 0.244 r64 0.285 full20k 0.259 full108k 0.273 | factor r16/own 1.496
374
+ HSPC s162k own 1.313 | at depth r16 1.472 r64 1.527 full20k 1.499 full108k 1.501 | factor r16/own 1.121
375
+ Cytotoxic CD4 T s162k own 0.940 | at depth r16 1.073 r64 1.143 full20k 1.020 full108k 1.076 | factor r16/own 1.141
376
+ Granulocyte-like (LDG) s162k own 0.012 | at depth r16 0.021 r64 0.024 full20k 0.023 full108k 0.023 | factor r16/own 1.803
377
+ Platelet signal in monocytes (negative control) s162k own 0.078 | at depth r16 0.165 r64 0.174 full20k 0.192 full108k 0.175 | factor r16/own 2.114
378
+ label state Proliferating T (label): obsthin sums across arms {4793}; obs_state 4793
379
+ label state Plasmablast (label): obsthin sums across arms {8423}; obs_state 8423
380
+
381
+ === cross-5 ===
382
+ HSPC: obsthin_state over 12 arms: min 629 max 741; native 741
383
+ s162k[own] ratio 1.313 ps 1.315 [1.034,1.729] gen 203/123000 obs 741/589478 (native 741)
384
+ r16[own] ratio 1.617 ps 1.619 [1.149,2.310] gen 223/123000 obs 661/589478 (native 741)
385
+ r64[own] ratio 2.957 ps 2.958 [2.062,4.233] gen 393/123000 obs 637/589478 (native 741)
386
+ full20k[own] ratio 1.403 ps 1.406 [1.021,1.962] gen 190/123000 obs 649/589478 (native 741)
387
+ full108k[own] ratio 2.966 ps 2.967 [2.093,4.220] gen 401/123000 obs 648/589478 (native 741)
388
+ xcal[own] ratio 1.681 ps 1.683 [1.215,2.367] gen 248/123000 obs 707/589478 (native 741)
389
+ zs[own] ratio 0.549 ps 0.552 [0.345,0.809] gen 72/123000 obs 629/589478 (native 741)
390
+ own58[own] ratio 0.399 ps 0.402 [0.252,0.597] gen 61/123000 obs 732/589478 (native 741)
391
+ s162k[depth_r16] ratio 1.472 ps 1.474 [1.143,1.992] gen 203/123000 obs 661/589478 (native 741)
392
+ D s162k-r16 [own] HSPC: -0.300 [-0.635,+0.086] (raw-point -0.300) ratios 1.313 vs 1.617 -> ns
393
+ D s162k-r16 [matched_depth] HSPC: -0.135 [-0.473,+0.247] (raw-point -0.136) ratios 1.472 vs 1.617 -> ns
394
+ D s162k-r64 [own] HSPC: -1.169 [-1.494,-0.810] (raw-point -1.171) ratios 1.313 vs 2.957 -> scratch_closer
395
+ D s162k-r64 [matched_depth] HSPC: -0.951 [-1.262,-0.595] (raw-point -0.953) ratios 1.527 vs 2.957 -> scratch_closer
396
+ D s162k-full108k [own] HSPC: -1.174 [-1.526,-0.794] (raw-point -1.176) ratios 1.313 vs 2.966 -> scratch_closer
397
+ D s162k-full108k [matched_depth] HSPC: -0.980 [-1.342,-0.602] (raw-point -0.982) ratios 1.501 vs 2.966 -> scratch_closer
398
+ D s162k-xcal [own] HSPC: -0.356 [-0.698,+0.016] (raw-point -0.357) ratios 1.313 vs 1.681 -> ns
399
+ D s162k-xcal [matched_depth] HSPC: -0.191 [-0.536,+0.195] (raw-point -0.192) ratios 1.472 vs 1.681 -> ns
400
+ D s162k-full20k [own] HSPC: -0.096 [-0.448,+0.276] (raw-point -0.096) ratios 1.313 vs 1.403 -> ns
401
+ D s162k-full20k [matched_depth] HSPC: +0.095 [-0.262,+0.470] (raw-point +0.095) ratios 1.499 vs 1.403 -> ns
402
+ Cytotoxic CD4 T: obsthin_state over 12 arms: min 1721 max 2091; native 2091
403
+ s162k[own] ratio 0.940 ps 0.942 [0.710,1.263] gen 289/20606 obs 2091/140213 (native 2091)
404
+ r16[own] ratio 1.409 ps 1.411 [1.049,1.901] gen 340/18454 obs 1833/140213 (native 2091)
405
+ r64[own] ratio 1.701 ps 1.703 [1.281,2.322] gen 372/17818 obs 1721/140213 (native 2091)
406
+ full20k[own] ratio 1.622 ps 1.623 [1.213,2.142] gen 412/18475 obs 1928/140213 (native 2091)
407
+ full108k[own] ratio 1.609 ps 1.611 [1.211,2.175] gen 330/15734 obs 1828/140213 (native 2091)
408
+ xcal[own] ratio 2.024 ps 2.026 [1.558,2.669] gen 457/15566 obs 2034/140213 (native 2091)
409
+ zs[own] ratio 0.431 ps 0.433 [0.324,0.581] gen 85/15654 obs 1767/140213 (native 2091)
410
+ own58[own] ratio 1.350 ps 1.351 [1.094,1.677] gen 609/30246 obs 2091/140213 (native 2091)
411
+ s162k[depth_r16] ratio 1.073 ps 1.074 [0.793,1.475] gen 289/20606 obs 1833/140213 (native 2091)
412
+ D s162k-r16 [own] Cytotoxic CD4 T: -0.410 [-0.766,+0.329] (raw-point -0.406) ratios 0.940 vs 1.409 -> ns
413
+ D s162k-r16 [matched_depth] Cytotoxic CD4 T: -0.393 [-0.670,+0.172] (raw-point -0.394) ratios 1.073 vs 1.409 -> ns
414
+ D s162k-r64 [own] Cytotoxic CD4 T: -0.681 [-1.043,+0.078] (raw-point -0.678) ratios 0.940 vs 1.701 -> ns
415
+ D s162k-r64 [matched_depth] Cytotoxic CD4 T: -0.573 [-0.872,-0.120] (raw-point -0.574) ratios 1.143 vs 1.701 -> scratch_closer
416
+ D s162k-full108k [own] Cytotoxic CD4 T: -0.601 [-0.978,+0.111] (raw-point -0.597) ratios 0.940 vs 1.609 -> ns
417
+ D s162k-full108k [matched_depth] Cytotoxic CD4 T: -0.580 [-0.876,-0.058] (raw-point -0.581) ratios 1.076 vs 1.609 -> scratch_closer
418
+ D s162k-xcal [own] Cytotoxic CD4 T: -0.932 [-1.280,-0.261] (raw-point -0.929) ratios 0.940 vs 2.024 -> scratch_closer
419
+ D s162k-xcal [matched_depth] Cytotoxic CD4 T: -0.915 [-1.181,-0.378] (raw-point -0.916) ratios 1.073 vs 2.024 -> scratch_closer
420
+ D s162k-full20k [own] Cytotoxic CD4 T: -0.613 [-0.971,+0.111] (raw-point -0.609) ratios 0.940 vs 1.622 -> ns
421
+ D s162k-full20k [matched_depth] Cytotoxic CD4 T: -0.668 [-0.922,+0.019] (raw-point -0.669) ratios 1.020 vs 1.622 -> ns
422
+ Plasmablast (label): obsthin_state over 12 arms: min 8423 max 8423; native 8423
423
+ s162k[own] ratio 0.875 ps 0.875 [0.669,1.213] gen 1537/123000 obs 8423/589478 (native 8423)
424
+ r16[own] ratio 1.377 ps 1.377 [0.978,2.173] gen 2420/123000 obs 8423/589478 (native 8423)
425
+ r64[own] ratio 1.010 ps 1.010 [0.700,1.546] gen 1775/123000 obs 8423/589478 (native 8423)
426
+ full20k[own] ratio 1.774 ps 1.774 [1.219,2.707] gen 3117/123000 obs 8423/589478 (native 8423)
427
+ full108k[own] ratio 2.214 ps 2.214 [1.474,3.605] gen 3891/123000 obs 8423/589478 (native 8423)
428
+ xcal[own] ratio 0.779 ps 0.779 [0.533,1.234] gen 1369/123000 obs 8423/589478 (native 8423)
429
+ zs[own] ratio 0.386 ps 0.386 [0.260,0.611] gen 678/123000 obs 8423/589478 (native 8423)
430
+ own58[own] ratio 0.757 ps 0.758 [0.441,1.417] gen 1331/123000 obs 8423/589478 (native 8423)
431
+ s162k[depth_r16] ratio 0.875 ps 0.875 [0.669,1.213] gen 1537/123000 obs 8423/589478 (native 8423)
432
+ D s162k-r16 [own] Plasmablast (label): -0.269 [-0.936,+0.460] (raw-point -0.268) ratios 0.875 vs 1.377 -> ns
433
+ D s162k-r16 [matched_depth] Plasmablast (label): -0.269 [-0.936,+0.460] (raw-point -0.268) ratios 0.875 vs 1.377 -> ns
434
+ D s162k-r64 [own] Plasmablast (label): +0.178 [-0.469,+0.321] (raw-point +0.179) ratios 0.875 vs 1.010 -> ns
435
+ D s162k-r64 [matched_depth] Plasmablast (label): +0.178 [-0.469,+0.321] (raw-point +0.179) ratios 0.875 vs 1.010 -> ns
436
+ D s162k-full108k [own] Plasmablast (label): -0.954 [-1.652,-0.029] (raw-point -0.953) ratios 0.875 vs 2.214 -> scratch_closer
437
+ D s162k-full108k [matched_depth] Plasmablast (label): -0.954 [-1.652,-0.029] (raw-point -0.953) ratios 0.875 vs 2.214 -> scratch_closer
438
+ D s162k-xcal [own] Plasmablast (label): -0.167 [-0.532,+0.169] (raw-point -0.167) ratios 0.875 vs 0.779 -> ns
439
+ D s162k-xcal [matched_depth] Plasmablast (label): -0.167 [-0.532,+0.169] (raw-point -0.167) ratios 0.875 vs 0.779 -> ns
440
+ D s162k-full20k [own] Plasmablast (label): -0.634 [-1.282,+0.219] (raw-point -0.633) ratios 0.875 vs 1.774 -> ns
441
+ D s162k-full20k [matched_depth] Plasmablast (label): -0.634 [-1.282,+0.219] (raw-point -0.633) ratios 0.875 vs 1.774 -> ns
442
+ ISG-high T: obsthin_state over 12 arms: min 4514 max 10685; native 10685
443
+ s162k[own] ratio 0.599 ps 0.600 [0.292,1.007] gen 1188/55309 obs 10685/298117 (native 10685)
444
+ r16[own] ratio 1.662 ps 1.662 [1.007,3.119] gen 1839/51586 obs 6395/298117 (native 10685)
445
+ r64[own] ratio 1.927 ps 1.927 [1.046,3.849] gen 1710/47130 obs 5613/298117 (native 10685)
446
+ full20k[own] ratio 1.352 ps 1.352 [0.843,2.315] gen 1469/49480 obs 6546/298117 (native 10685)
447
+ full108k[own] ratio 2.051 ps 2.052 [1.140,3.670] gen 1975/47593 obs 6031/298117 (native 10685)
448
+ xcal[own] ratio 1.595 ps 1.595 [1.254,2.286] gen 2550/57613 obs 8275/298117 (native 10685)
449
+ zs[own] ratio 1.743 ps 1.744 [1.288,3.114] gen 1144/43347 obs 4514/298117 (native 10685)
450
+ own58[own] ratio 0.569 ps 0.570 [0.326,0.725] gen 1378/67850 obs 10634/298117 (native 10685)
451
+ s162k[depth_r16] ratio 1.001 ps 1.002 [0.456,1.872] gen 1188/55309 obs 6395/298117 (native 10685)
452
+ D s162k-r16 [own] ISG-high T: +0.005 [-1.379,+1.591] (raw-point +0.006) ratios 0.599 vs 1.662 -> ns
453
+ D s162k-r16 [matched_depth] ISG-high T: -0.731 [-1.271,+0.997] (raw-point -0.731) ratios 1.001 vs 1.662 -> ns
454
+ D s162k-r64 [own] ISG-high T: -0.209 [-1.702,+1.559] (raw-point -0.208) ratios 0.599 vs 1.927 -> ns
455
+ D s162k-r64 [matched_depth] ISG-high T: -0.756 [-1.298,+0.836] (raw-point -0.756) ratios 1.141 vs 1.927 -> ns
456
+ D s162k-full108k [own] ISG-high T: -0.299 [-1.744,+1.478] (raw-point -0.298) ratios 0.599 vs 2.051 -> ns
457
+ D s162k-full108k [matched_depth] ISG-high T: -0.950 [-1.254,+0.823] (raw-point -0.950) ratios 1.062 vs 2.051 -> ns
458
+ D s162k-xcal [own] ISG-high T: +0.065 [-0.931,+1.381] (raw-point +0.066) ratios 0.599 vs 1.595 -> ns
459
+ D s162k-xcal [matched_depth] ISG-high T: -0.671 [-0.849,+0.735] (raw-point -0.671) ratios 1.001 vs 1.595 -> ns
460
+ D s162k-full20k [own] ISG-high T: +0.303 [-1.035,+1.596] (raw-point +0.304) ratios 0.599 vs 1.352 -> ns
461
+ D s162k-full20k [matched_depth] ISG-high T: -0.404 [-0.801,+0.968] (raw-point -0.403) ratios 0.978 vs 1.352 -> ns
462
+ scratch significantly closer: s162k vs r16 [own]: C1Q-high monocyte (reference) (scr 0.068 vs comp 0.035)
463
+ scratch significantly closer: s162k vs r16 [matched_depth]: C1Q-high monocyte (reference) (scr 0.078 vs comp 0.035); DN2 / ABC B (scr 0.244 vs comp 0.173); Granulocyte-like (LDG) (scr 0.021 vs comp 0.010)
464
+ scratch significantly closer: s162k vs r64 [own]: HSPC (scr 1.313 vs comp 2.957)
465
+ scratch significantly closer: s162k vs r64 [matched_depth]: C1Q-high monocyte (reference) (scr 0.079 vs comp 0.056); DN2 / ABC B (scr 0.285 vs comp 0.182); HSPC (scr 1.527 vs comp 2.957); Cytotoxic CD4 T (scr 1.143 vs comp 1.701)
466
+ scratch significantly closer: s162k vs full108k [own]: Plasmablast (label) (scr 0.875 vs comp 2.214); HSPC (scr 1.313 vs comp 2.966)
467
+ scratch significantly closer: s162k vs full108k [matched_depth]: Plasmablast (label) (scr 0.875 vs comp 2.214); HSPC (scr 1.501 vs comp 2.966); Cytotoxic CD4 T (scr 1.076 vs comp 1.609)
468
+ scratch significantly closer: s162k vs xcal [own]: Cytotoxic CD4 T (scr 0.940 vs comp 2.024)
469
+ scratch significantly closer: s162k vs xcal [matched_depth]: Plasmablast (markers) (scr 0.530 vs comp 0.367); Cytotoxic CD4 T (scr 1.073 vs comp 2.024)
470
+ scratch significantly closer: s162k vs xcal [matched_depth_xcalref]: Cytotoxic CD4 T (scr 0.967 vs comp 2.024)
471
+
472
+ === cross-6 ===
473
+ arm zs xcal r16 r64 full20k full108k s50k s100k s150k s162k own5 own58
474
+ state
475
+ C1Q-high monocyte (reference) 0.149 0.112 0.018 0.055 0.084 0.018 0.206 0.234 0.276 0.100 0.152 0.217
476
+ Cycling T/NK 0.119 0.163 -0.128 -0.160 0.096 -0.023 0.001 0.013 0.012 -0.054 0.122 0.332
477
+ Cycling activated T (CD38/HLA-DR) 0.034 0.134 -0.082 0.084 0.232 0.038 -0.049 0.054 0.003 0.163 0.116 0.173
478
+ Cycling monocyte (Ye 2026) 0.191 0.417 0.034 0.097 0.138 0.318 0.274 0.223 0.062 0.072 0.165 0.128
479
+ Cytotoxic CD4 T 0.375 0.490 0.541 0.581 0.569 0.616 0.393 0.426 0.481 0.404 0.541 0.692
480
+ DN2 / ABC B 0.105 -0.063 0.109 0.315 0.059 0.390 0.077 0.154 0.059 0.105 0.047 0.423
481
+ Granulocyte-like (LDG) 0.417 0.308 -0.063 0.143 0.003 0.135 0.445 0.437 0.186 0.183 0.354 0.378
482
+ HSPC -0.006 0.133 0.068 0.096 0.157 0.070 0.189 0.103 0.293 0.275 -0.001 0.049
483
+ ISG-high T 0.432 0.552 0.533 0.514 0.443 0.472 0.248 0.379 0.343 0.383 0.519 0.699
484
+ ISG-high monocyte (positive control) 0.496 0.501 0.422 0.487 0.432 0.458 0.442 0.405 0.402 0.406 0.309 0.601
485
+ MS1 monocyte (IL1R2+) 0.526 0.647 0.400 0.419 0.543 0.505 0.511 0.510 0.409 0.523 0.439 0.571
486
+ Plasmablast (label) 0.332 0.413 0.356 0.375 0.330 0.228 0.361 0.292 0.286 0.315 0.125 0.195
487
+ Plasmablast (markers) 0.376 0.489 0.478 0.439 0.435 0.347 0.429 0.485 0.492 0.507 0.370 0.433
488
+ Platelet signal in monocytes (negative control) 0.234 0.220 0.148 0.357 0.218 0.269 0.307 0.192 0.228 0.159 0.203 0.100
489
+ Proliferating T (label) -0.019 0.081 0.068 0.138 0.074 0.036 -0.088 0.076 0.034 0.093 0.222 0.386
490
+ s162k vs r16: sig 0/13 ([]), range -0.150..+0.246, mean +0.057
491
+ min: ['ISG-high T', np.float64(0.383182908008798), np.float64(0.5334285073517612)] max: ['Granulocyte-like (LDG)', np.float64(0.18319623791935583), np.float64(-0.06285102421788866)]
492
+ s162k vs r64: sig 0/13 ([]), range -0.210..+0.179, mean -0.002
493
+ min: ['DN2 / ABC B', np.float64(0.10462683508313289), np.float64(0.31486762872563817)] max: ['HSPC', np.float64(0.2750474577967008), np.float64(0.09636977747707148)]
494
+ s162k vs full108k: sig 2/13 ([{'state': 'DN2 / ABC B', 'rho_scratch': 0.105, 'rho_comparator': 0.39, 'diff': -0.286, 'ci_lo': -0.55, 'ci_hi': -0.013, 'verdict': 'comparator_higher'}, {'state': 'Cytotoxic CD4 T', 'rho_scratch': 0.404, 'rho_comparator': 0.616, 'diff': -0.211, 'ci_lo': -0.422, 'ci_hi': -0.001, 'verdict': 'comparator_higher'}]), range -0.286..+0.205, mean -0.006
495
+ min: ['DN2 / ABC B', np.float64(0.10462683508313289), np.float64(0.3903288195291378)] max: ['HSPC', np.float64(0.2750474577967008), np.float64(0.07030085169808331)]
496
+ s162k vs xcal: sig 2/13 ([{'state': 'Cycling monocyte (Ye 2026)', 'rho_scratch': 0.072, 'rho_comparator': 0.417, 'diff': -0.345, 'ci_lo': -0.615, 'ci_hi': -0.061, 'verdict': 'comparator_higher'}, {'state': 'ISG-high T', 'rho_scratch': 0.383, 'rho_comparator': 0.552, 'diff': -0.169, 'ci_lo': -0.348, 'ci_hi': -0.012, 'verdict': 'comparator_higher'}]), range -0.345..+0.168, mean -0.062
497
+ min: ['Cycling monocyte (Ye 2026)', np.float64(0.0719522992896303), np.float64(0.4166828651083665)] max: ['DN2 / ABC B', np.float64(0.10462683508313289), np.float64(-0.06334723274496683)]
498
+ s162k vs full20k: sig 0/13 ([]), range -0.165..+0.180, mean -0.007
499
+ min: ['Cytotoxic CD4 T', np.float64(0.4044710538546303), np.float64(0.5690688314846367)] max: ['Granulocyte-like (LDG)', np.float64(0.18319623791935583), np.float64(0.0029172406103594533)]
500
+ s162k vs own58: sig 5/13 ([{'state': 'Cycling T/NK', 'rho_scratch': -0.054, 'rho_comparator': 0.332, 'diff': -0.386, 'ci_lo': -0.709, 'ci_hi': -0.052, 'verdict': 'comparator_higher'}, {'state': 'Proliferating T (label)', 'rho_scratch': 0.093, 'rho_comparator': 0.386, 'diff': -0.293, 'ci_lo': -0.563, 'ci_hi': -0.022, 'verdict': 'comparator_higher'}, {'state': 'ISG-high T', 'rho_scratch': 0.383, 'rho_comparator': 0.699, 'diff': -0.315, 'ci_lo': -0.537, 'ci_hi': -0.089, 'verdict': 'comparator_higher'}, {'state': 'DN2 / ABC B', 'rho_scratch': 0.105, 'rho_comparator': 0.423, 'diff': -0.318, 'ci_lo': -0.57, 'ci_hi': -0.072, 'verdict': 'comparator_higher'}, {'state': 'Cytotoxic CD4 T', 'rho_scratch': 0.404, 'rho_comparator': 0.692, 'diff': -0.288, 'ci_lo': -0.506, 'ci_hi': -0.068, 'verdict': 'comparator_higher'}]), range -0.386..+0.226, mean -0.124
501
+ min: ['Cycling T/NK', np.float64(-0.0540343591142522), np.float64(0.3321315547445843)] max: ['HSPC', np.float64(0.2750474577967008), np.float64(0.04933981769899803)]
502
+ mean rho over 13 rare states per arm: {'full108k': 0.242, 'full20k': 0.243, 'own5': 0.244, 'own58': 0.36, 'r16': 0.179, 'r64': 0.238, 's100k': 0.261, 's150k': 0.226, 's162k': 0.236, 's50k': 0.231, 'xcal': 0.298, 'zs': 0.233}
503
+ median rho per arm: {'full108k': 0.228, 'full20k': 0.157, 'own5': 0.165, 'own58': 0.378, 'r16': 0.068, 'r64': 0.143, 's100k': 0.234, 's150k': 0.276, 's162k': 0.183, 's50k': 0.248, 'xcal': 0.308, 'zs': 0.191}
504
+ cross-cohort arms rho: n 130, in [0,0.55]: 114, <0: 11, >0.55: 5, max 0.647
505
+ per state, arm with max rho: {'C1Q-high monocyte (reference)': 's150k', 'Cycling T/NK': 'own58', 'Cycling activated T (CD38/HLA-DR)': 'full20k', 'Cycling monocyte (Ye 2026)': 'xcal', 'Cytotoxic CD4 T': 'own58', 'DN2 / ABC B': 'own58', 'Granulocyte-like (LDG)': 's50k', 'HSPC': 's150k', 'ISG-high T': 'own58', 'MS1 monocyte (IL1R2+)': 'xcal', 'Plasmablast (label)': 'xcal', 'Plasmablast (markers)': 's162k', 'Proliferating T (label)': 'own58'}
506
+
507
+ === cross-7 ===
508
+ common set size: 21
509
+ [('C1Q-high monocyte (reference)', 'adult'), ('C1Q-high monocyte (reference)', 'all'), ('C1Q-high monocyte (reference)', 'paediatric'), ('Cycling monocyte (Ye 2026)', 'adult'), ('Cycling monocyte (Ye 2026)', 'all'), ('Cycling monocyte (Ye 2026)', 'paediatric'), ('Cytotoxic CD4 T', 'adult'), ('Cytotoxic CD4 T', 'all'), ('Granulocyte-like (LDG)', 'adult'), ('Granulocyte-like (LDG)', 'all'), ('Granulocyte-like (LDG)', 'paediatric'), ('ISG-high T', 'adult'), ('ISG-high T', 'all'), ('ISG-high T', 'paediatric'), ('MS1 monocyte (IL1R2+)', 'adult'), ('MS1 monocyte (IL1R2+)', 'all'), ('MS1 monocyte (IL1R2+)', 'paediatric'), ('Plasmablast (label)', 'adult'), ('Plasmablast (markers)', 'adult'), ('Plasmablast (markers)', 'paediatric'), ('Proliferating T (label)', 'all')]
510
+ arm variant n kept reversed median_frac_kept median_frac_all_common_signed mean_frac_all_common_signed
511
+ zs own 21 15 6 0.092 0.052 -0.056
512
+ xcal own 21 19 2 0.229 0.147 0.312
513
+ r16 own 21 11 10 0.137 0.005 0.061
514
+ r64 own 21 10 11 0.131 -0.000 0.037
515
+ full20k own 21 15 6 0.290 0.170 0.196
516
+ full108k own 21 16 5 0.150 0.106 -0.022
517
+ s50k own 21 15 6 0.074 0.049 -0.106
518
+ s50k depth_r16 21 15 6 0.116 0.076 -0.067
519
+ s100k own 21 15 6 0.036 0.024 -0.081
520
+ s100k depth_r16 21 15 6 0.055 0.027 -0.041
521
+ s150k own 21 16 5 0.034 0.018 -0.100
522
+ s150k depth_r16 21 16 5 0.048 0.032 -0.065
523
+ s162k own 21 14 7 0.042 0.024 -0.134
524
+ s162k depth_r16 21 14 7 0.067 0.029 -0.099
525
+ own5 own 21 17 4 0.245 0.181 0.214
526
+ own58 own 21 19 2 0.344 0.312 0.369
527
+ lost zs[own]: C1Q-high monocyte (reference)|paediatric; Proliferating T (label)|all; Plasmablast (markers)|paediatric; Cycling monocyte (Ye 2026)|adult; Cytotoxic CD4 T|adult; Cytotoxic CD4 T|all
528
+ lost xcal[own]: Proliferating T (label)|all; Plasmablast (markers)|paediatric
529
+ lost r16[own]: C1Q-high monocyte (reference)|adult; C1Q-high monocyte (reference)|paediatric; C1Q-high monocyte (reference)|all; Proliferating T (label)|all; Plasmablast (markers)|paediatric; ISG-high T|all; Cytotoxic CD4 T|adult; Cytotoxic CD4 T|all; Granulocyte-like (LDG)|adult; Granulocyte-like (LDG)|all
530
+ lost r64[own]: C1Q-high monocyte (reference)|paediatric; C1Q-high monocyte (reference)|all; Proliferating T (label)|all; Plasmablast (markers)|paediatric; Cycling monocyte (Ye 2026)|paediatric; ISG-high T|all; Cytotoxic CD4 T|adult; Cytotoxic CD4 T|all; Granulocyte-like (LDG)|adult; Granulocyte-like (LDG)|paediatric; Granulocyte-like (LDG)|all
531
+ lost full20k[own]: C1Q-high monocyte (reference)|adult; C1Q-high monocyte (reference)|paediatric; C1Q-high monocyte (reference)|all; Proliferating T (label)|all; Plasmablast (markers)|paediatric; Cytotoxic CD4 T|all
532
+ lost full108k[own]: C1Q-high monocyte (reference)|adult; Proliferating T (label)|all; Plasmablast (markers)|paediatric; Cytotoxic CD4 T|adult; Cytotoxic CD4 T|all
533
+ lost s50k[own]: C1Q-high monocyte (reference)|adult; Proliferating T (label)|all; Plasmablast (markers)|paediatric; ISG-high T|all; Cytotoxic CD4 T|adult; Cytotoxic CD4 T|all
534
+ lost s50k[depth_r16]: C1Q-high monocyte (reference)|adult; Proliferating T (label)|all; Plasmablast (markers)|paediatric; ISG-high T|all; Cytotoxic CD4 T|adult; Cytotoxic CD4 T|all
535
+ lost s100k[own]: C1Q-high monocyte (reference)|paediatric; Proliferating T (label)|all; Plasmablast (markers)|paediatric; ISG-high T|all; Cytotoxic CD4 T|adult; Cytotoxic CD4 T|all
536
+ lost s100k[depth_r16]: C1Q-high monocyte (reference)|paediatric; Proliferating T (label)|all; Plasmablast (markers)|paediatric; ISG-high T|all; Cytotoxic CD4 T|adult; Cytotoxic CD4 T|all
537
+ lost s150k[own]: Proliferating T (label)|all; Plasmablast (markers)|paediatric; ISG-high T|all; Cytotoxic CD4 T|adult; Cytotoxic CD4 T|all
538
+ lost s150k[depth_r16]: Proliferating T (label)|all; Plasmablast (markers)|paediatric; ISG-high T|all; Cytotoxic CD4 T|adult; Cytotoxic CD4 T|all
539
+ lost s162k[own]: C1Q-high monocyte (reference)|paediatric; Proliferating T (label)|all; Plasmablast (markers)|paediatric; ISG-high T|all; Cytotoxic CD4 T|adult; Cytotoxic CD4 T|all; Granulocyte-like (LDG)|paediatric
540
+ lost s162k[depth_r16]: C1Q-high monocyte (reference)|paediatric; Proliferating T (label)|all; Plasmablast (markers)|paediatric; ISG-high T|all; Cytotoxic CD4 T|adult; Cytotoxic CD4 T|all; Granulocyte-like (LDG)|paediatric
541
+ lost own5[own]: C1Q-high monocyte (reference)|adult; Proliferating T (label)|all; Plasmablast (markers)|paediatric; ISG-high T|all
542
+ lost own58[own]: Proliferating T (label)|all; Plasmablast (markers)|paediatric
543
+ arm zs xcal r16 r64 full20k full108k s50k s100k s150k s162k own5 own58
544
+ state contrast
545
+ C1Q-high monocyte (reference) adult 1 1 0 1 0 0 0 1 1 1 0 1
546
+ all 1 1 0 0 0 1 1 1 1 1 1 1
547
+ paediatric 0 1 0 0 0 1 1 0 1 0 1 1
548
+ Cycling monocyte (Ye 2026) adult 0 1 1 1 1 1 1 1 1 1 1 1
549
+ all 1 1 1 1 1 1 1 1 1 1 1 1
550
+ paediatric 1 1 1 0 1 1 1 1 1 1 1 1
551
+ Cytotoxic CD4 T adult 0 1 0 0 1 0 0 0 0 0 1 1
552
+ all 0 1 0 0 0 0 0 0 0 0 1 1
553
+ Granulocyte-like (LDG) adult 1 1 0 0 1 1 1 1 1 1 1 1
554
+ all 1 1 0 0 1 1 1 1 1 1 1 1
555
+ paediatric 1 1 1 0 1 1 1 1 1 0 1 1
556
+ ISG-high T adult 1 1 1 1 1 1 1 1 1 1 1 1
557
+ all 1 1 0 0 1 1 0 0 0 0 0 1
558
+ paediatric 1 1 1 1 1 1 1 1 1 1 1 1
559
+ MS1 monocyte (IL1R2+) adult 1 1 1 1 1 1 1 1 1 1 1 1
560
+ all 1 1 1 1 1 1 1 1 1 1 1 1
561
+ paediatric 1 1 1 1 1 1 1 1 1 1 1 1
562
+ Plasmablast (label) adult 1 1 1 1 1 1 1 1 1 1 1 1
563
+ Plasmablast (markers) adult 1 1 1 1 1 1 1 1 1 1 1 1
564
+ paediatric 0 0 0 0 0 0 0 0 0 0 0 0
565
+ Proliferating T (label) all 0 0 0 0 0 0 0 0 0 0 0 0
566
+ min max
567
+ state contrast
568
+ Plasmablast (markers) adult 1.256728 1.878801
569
+ paediatric -1.672452 -1.176543
570
+ Proliferating T (label) all -0.623108 -0.623108
571
+ s162k[own] C1Q-high monocyte (reference) | adult: gen +0.25 obs +6.14 frac +0.041 same=True | r16[own] C1Q-high monocyte (reference) | adult: gen -0.24 obs +5.58 frac -0.042 same=False
572
+ s162k[own] C1Q-high monocyte (reference) | all: gen +0.08 obs +6.91 frac +0.012 same=True | r16[own] C1Q-high monocyte (reference) | all: gen -0.08 obs +6.18 frac -0.013 same=False
573
+ s162k[own] C1Q-high monocyte (reference) | paediatric: gen -0.13 obs +9.37 frac -0.014 same=False | r16[own] C1Q-high monocyte (reference) | paediatric: gen -0.05 obs +8.21 frac -0.006 same=False
574
+
575
+ === cross-8 ===
576
+ C1Q-high monocyte (reference) 0.092 -> 0.082 -> 0.070 -> 0.068
577
+ Cycling T/NK 0.061 -> 0.124 -> 0.068 -> 0.049
578
+ Cycling activated T (CD38/HLA-DR) 0.079 -> 0.108 -> 0.073 -> 0.051
579
+ Proliferating T (label) 0.444 -> 0.521 -> 0.564 -> 0.532
580
+ Plasmablast (label) 0.486 -> 0.675 -> 0.794 -> 0.875
581
+ Plasmablast (markers) 0.262 -> 0.307 -> 0.330 -> 0.338
582
+ MS1 monocyte (IL1R2+) 0.158 -> 0.116 -> 0.105 -> 0.102
583
+ Cycling monocyte (Ye 2026) 0.059 -> 0.022 -> 0.020 -> 0.024
584
+ ISG-high T 0.697 -> 0.567 -> 0.602 -> 0.599
585
+ DN2 / ABC B 0.157 -> 0.166 -> 0.176 -> 0.163
586
+ HSPC 0.957 -> 2.581 -> 1.300 -> 1.313
587
+ Cytotoxic CD4 T 0.860 -> 1.005 -> 0.950 -> 0.940
588
+ Granulocyte-like (LDG) 0.035 -> 0.015 -> 0.011 -> 0.012
589
+ s50k mean|log2| 2.327 [2.120,2.596]
590
+ s100k mean|log2| 2.495 [2.273,2.791]
591
+ s150k mean|log2| 2.560 [2.347,2.824]
592
+ s162k mean|log2| 2.615 [2.428,2.865]
593
+ name variant value ci_lo ci_hi
594
+ s162k vs s50k own 0.288164 0.153021 0.424933
595
+ s162k vs s50k both_at_r16_depth 0.279748 0.155550 0.422547
596
+ name variant value ci_lo ci_hi
597
+ s162k vs s100k own 0.120133 -0.010789 0.242071
598
+ s162k vs s100k both_at_r16_depth 0.107204 -0.016626 0.242179
599
+ name variant value ci_lo ci_hi
600
+ s162k vs s150k own 0.054595 -0.061029 0.171858
601
+ s162k vs s150k both_at_r16_depth 0.051483 -0.059479 0.171470
602
+ name variant value ci_lo ci_hi
603
+ s50k vs r16 own 0.011447 -0.191671 0.244829
604
+ s50k vs r16 matched_depth -0.386236 -0.540089 -0.173101
605
+ name variant value ci_lo ci_hi
606
+ s162k vs r16 own 0.299611 0.092872 0.519740
607
+ s162k vs r16 matched_depth -0.106488 -0.242692 0.112003
608
+ s162k vs s50k [own] s50k closer (comparator_closer): ['C1Q-high monocyte (reference)', 'Cycling activated T (CD38/HLA-DR)', 'MS1 monocyte (IL1R2+)', 'Cycling monocyte (Ye 2026)', 'Granulocyte-like (LDG)']; s162k closer: ['Proliferating T (label)', 'Plasmablast (label)', 'Plasmablast (markers)']
609
+ s162k vs s50k [both_at_r16_depth] s50k closer (comparator_closer): ['C1Q-high monocyte (reference)', 'Cycling activated T (CD38/HLA-DR)', 'MS1 monocyte (IL1R2+)', 'Cycling monocyte (Ye 2026)', 'Granulocyte-like (LDG)']; s162k closer: ['Proliferating T (label)', 'Plasmablast (label)', 'Plasmablast (markers)']
610
+ arm median_lib_all_cells bench_coverage bench_precision
611
+ zs 973.0 0.073984 0.616992
612
+ xcal 1628.0 0.463821 0.896098
613
+ r16 1135.0 0.341382 0.861138
614
+ r64 1013.0 0.289187 0.828130
615
+ full20k 1070.0 0.329268 0.837642
616
+ full108k 1055.0 0.345691 0.820813
617
+ s50k 13891.0 0.062602 0.999350
618
+ s100k 19138.0 0.037073 0.999837
619
+ s150k 20524.0 0.033984 0.999593
620
+ s162k 20606.0 0.031789 0.999756
621
+ own5 1786.0 NaN NaN
622
+ own58 1882.0 NaN NaN
paper-releases/pbisc-diffusion/updates/20261005T142225Z-rare-states-scratch-vs-pretrained/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/out/scratch_vs_lora_20261005/verify_recompute_within_donorweight.log ADDED
@@ -0,0 +1,25 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ arm zs__raw lora_n5__raw scratch_n5__raw real_lora__raw real_full__raw scratch_full__raw lora_recipe__raw scratch_recipe__raw
2
+ state
3
+ C1Q-high monocyte (reference) 0.019 0.784 0.809 0.753 0.852 0.461 0.497 0.611
4
+ Cycling T/NK 2.217 1.129 0.399 0.867 1.139 0.346 0.854 0.389
5
+ Cycling activated T (CD38/HLA-DR) 0.623 0.467 0.354 0.424 0.526 0.288 0.436 0.258
6
+ Cycling monocyte (Ye 2026) 0.077 0.096 0.049 0.071 0.128 0.073 0.098 0.081
7
+ Cytotoxic CD4 T 0.514 1.622 1.334 0.842 1.283 0.700 1.229 1.056
8
+ DN2 / ABC B 1.140 1.059 1.266 0.445 0.421 0.673 0.303 0.470
9
+ Granulocyte-like (LDG) 0.096 0.042 0.098 0.029 0.031 0.032 0.019 0.044
10
+ HSPC 0.839 0.941 0.471 0.568 0.766 1.319 0.694 0.936
11
+ ISG-high T 1.767 0.238 0.079 0.189 0.237 0.089 0.280 0.102
12
+ ISG-high monocyte (positive control) 1.656 0.288 0.264 0.352 0.425 0.258 0.460 0.210
13
+ MS1 monocyte (IL1R2+) 0.059 0.116 0.091 0.215 0.366 0.356 0.270 0.394
14
+ Plasmablast (label) 1.282 1.595 0.957 2.958 2.792 1.055 1.957 1.000
15
+ Plasmablast (markers) 0.718 0.479 0.333 0.990 1.092 0.609 0.674 0.694
16
+ Platelet signal in monocytes (negative control) 0.307 0.767 0.693 0.502 0.733 0.427 0.505 0.487
17
+ Proliferating T (label) 3.406 2.090 1.062 1.246 1.443 0.893 1.385 0.785
18
+ what arm state D ci_lo ci_hi mean_abs_log2_scratch mean_abs_log2_pretrained
19
+ mean D (13 rare states, donor-weighted) scratch_n5__raw - lora_n5__raw 5 pairs 0.237 -0.089 0.477 1.654 1.418
20
+ mean D (13 rare states, donor-weighted) scratch_full__raw - real_lora__raw 58 pairs vs LoRA 0.083 -0.307 0.367 1.585 1.502
21
+ mean D (13 rare states, donor-weighted) scratch_full__raw - real_full__raw 58 pairs vs full FT 0.278 -0.022 0.601 1.585 1.306
22
+ mean D (13 rare states, donor-weighted) scratch_recipe__raw - lora_recipe__raw recipes -0.065 -0.350 0.249 1.457 1.522
23
+ mean D (13 rare states, donor-weighted) scratch_n5__raw - zs__raw zs ref: 5 pairs -0.157 -0.536 0.122 1.654 1.811
24
+ mean D (13 rare states, donor-weighted) scratch_full__raw - zs__raw zs ref: 58 pairs -0.226 -0.666 0.126 1.585 1.811
25
+ mean D (13 rare states, donor-weighted) scratch_recipe__raw - zs__raw zs ref: recipes -0.354 -0.757 -0.007 1.457 1.811
paper-releases/pbisc-diffusion/updates/20261005T142225Z-rare-states-scratch-vs-pretrained/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/out/scratch_vs_lora_20261005/verify_recompute_within_label_marker.err ADDED
@@ -0,0 +1,23 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ Command being timed: "/home/sj_server_1/miniforge3/envs/cxg_corpus/bin/python verify_recompute_within_label_marker.py"
2
+ User time (seconds): 8.14
3
+ System time (seconds): 0.35
4
+ Percent of CPU this job got: 152%
5
+ Elapsed (wall clock) time (h:mm:ss or m:ss): 0:05.55
6
+ Average shared text size (kbytes): 0
7
+ Average unshared data size (kbytes): 0
8
+ Average stack size (kbytes): 0
9
+ Average total size (kbytes): 0
10
+ Maximum resident set size (kbytes): 3825564
11
+ Average resident set size (kbytes): 0
12
+ Major (requiring I/O) page faults: 0
13
+ Minor (reclaiming a frame) page faults: 52298
14
+ Voluntary context switches: 175
15
+ Involuntary context switches: 287
16
+ Swaps: 0
17
+ File system inputs: 0
18
+ File system outputs: 32
19
+ Socket messages sent: 0
20
+ Socket messages received: 0
21
+ Signals delivered: 0
22
+ Page size (bytes): 4096
23
+ Exit status: 0