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  1. paper-releases/pbisc-diffusion/updates/20261004T174508Z-sepsis-rare-states/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/README.md +149 -0
  2. paper-releases/pbisc-diffusion/updates/20261004T174508Z-sepsis-rare-states/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/analyze.err +15 -0
  3. paper-releases/pbisc-diffusion/updates/20261004T174508Z-sepsis-rare-states/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/analyze.log +422 -0
  4. paper-releases/pbisc-diffusion/updates/20261004T174508Z-sepsis-rare-states/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/extract_lora_n10__raw.err +0 -0
paper-releases/pbisc-diffusion/updates/20261004T174508Z-sepsis-rare-states/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/README.md ADDED
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+ # Rare disease-associated states beyond C1Q-high monocytes (2026-10-04/05)
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+
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+ **Question (user).** The model seems to follow the rise of C1Q-high monocytes to some degree. Which other rare,
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+ disease-specific subtypes would be worth testing the same way?
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+
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+ **Two parts.**
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+ 1. A literature survey of rare PBMC states.
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+ - 14 candidates, with key papers and marker genes.
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+ - 43 PDFs in `paper-release-20260928/reference-papers/rare-disease-states/`, listed in the `INDEX.md` there.
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+ 2. A screen of the zero-shot arms we already had, with no new generation:
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+ - The arms are DRESS (in the corpus), and Kawasaki and SLE GSE135779 (not in the corpus).
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+ - Model: final f01 6k E16. Each sample's own pseudobulk is the condition at K = 1,000, with seed 20260913.
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+ - Read-out: Poisson, seed 20260916. Labels: frozen f01common scANVI.
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+ - Each state was scored on generated and observed cells with the paper-based marker rules in
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+ `tools/states.json`.
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+ - Observed parent cells are binomially thinned to the generated median library, as in `c1q_crossdisease`.
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+
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+ ## Results (counts: state cells / parent cells; observed thinned)
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+
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+ | state (rule) | dataset | generated | observed | gen/obs | Spearman | disease direction |
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+ |---|---|---|---|---:|---:|---|
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+ | **MS1 monocyte** (IL1R2 + ≥ 2 of RETN ALOX5AP CYP1B1 MCEMP1 PLAC8 CLU CD163) | Kawasaki | KD before 317 / 4,450; HC 0 / 798; after IVIG 28 / 2,679 | 697 / 5,923; 1 / 1,123; 16 / 4,004 | 0.67 | 0.55 | **both kept** |
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+ | | SLE | 21 / 21,833 | 3,105 / 70,901 | 0.02 | −0.03 | lost |
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+ | **ISG-high T** (≥ 4 of 10 ISGs) | SLE | aSLE 746 / 12,979; aHD 29 / 10,265; cSLE 4,989 / 60,156; cHD 55 / 23,121 | 3,767 / 20,730; 175 / 27,704; 21,953 / 111,977; 450 / 56,080 | 0.45 | **0.86** | **both kept** |
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+ | ISG-high monocyte (positive control) | SLE | 7,372 / 21,833 | 27,715 / 70,901 | 0.86 | 0.86 | both kept |
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+ | **Cycling T/NK** (≥ 2 of MKI67 TOP2A TYMS CENPF UBE2C BIRC5) | SLE | 688 / 124,845 | 1,553 / 238,992 | 0.85 | 0.68 | both kept |
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+ | | DRESS | patient 32 / 3,857; HV 1 / 3,370 | 882 / 5,633; 20 / 5,650 | 0.32 | 0.78 | kept, compressed |
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+ | | Kawasaki | 92 / 45,425 | 1,163 / 63,360 | 0.11 | 0.34 | mixed |
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+ | **Plasmablast** (scANVI 'Plasma cell') | Kawasaki | 206 / 75,000 | 1,837 / 103,362 | 0.16 | 0.56 | kept (KD vs HC, before vs after) |
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+ | | SLE | 85 / 168,000 | 1,526 / 358,235 | 0.12 | 0.19 | child kept, adult reversed |
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+ | C1Q-high monocyte (reference) | Kawasaki / SLE / DRESS | 43 / 7,927; 109 / 21,833; 110 / 3,793 | 603 / 11,050; 1,800 / 70,901; 529 / 4,485 | 0.10 / 0.20 / 0.25 | 0.17 / 0.43 / 0.96 | mixed |
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+ | **DN2 / ABC B** (ITGAX or TBX21 + ≥ 2 of 7, CR2 absent) | SLE | 40 / 19,311 | 931 / 35,488 | 0.08 | 0.04 | adult weak, child reversed |
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+ | HSPC (≥ 2 of CD34 PRSS57 SPINK2 SMIM24) | SLE | 12 / 168,000 | 265 / 358,235 | 0.10 | 0.13 | too rare to judge |
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+ | **Granulocyte-like / LDG** (≥ 2 of 9 granule and neutrophil genes) | Kawasaki | 16 / 75,000 | 2,974 / 103,362 | **0.007** | 0.85 | not generated |
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+
36
+ The full tables are in `out/summary.csv`, `out/contrasts.csv` and `out/per_sample.csv`. The v1 run used provisional
37
+ marker rules; its tables are kept in `out/v1_provisional_markers/`.
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+
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+ **Corpus frequency** (`out/corpus_states.csv`; corpus sample of 179,750 cells, native depth):
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+ - MS1 (IL1R2+) is 6.9 % of monocytes, mostly from the COVID datasets.
41
+ - ISG-high T is 5.2 % of T cells.
42
+ - DN2 / ABC is 5.2 % of B cells.
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+ - Granulocyte-like cells are 2.4 % of all cells.
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+ - Plasmablasts (label) are 0.47 % of all cells.
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+
46
+ So the poorly generated states, DN2 and LDG, are **present in the corpus**. Corpus absence does not explain them.
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+
48
+ ## Reading
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+
50
+ 1. **What is reproduced, even outside the corpus.** These are states carried by a strong, broad program in the bulk:
51
+ - Kawasaki MS1 monocytes: present before IVIG, absent in controls, gone after IVIG.
52
+ - SLE ISG-high T cells, a rare state in healthy donors.
53
+ - Cycling T cells in SLE.
54
+
55
+ Direction and sample ranking are kept. Kawasaki MS1 matches the Gold 2026 reanalysis of the same cohort.
56
+ 2. **What is compressed but directional.** Plasmablasts and C1Q-high monocytes come out at 0.1–0.25× and follow the
57
+ disease direction only in some contrasts.
58
+ 3. **What fails.**
59
+ - DN2 / ABC B cells: 0.08×, no sample tracking.
60
+ - Granulocyte-like / LDG cells: essentially never generated, although present in the corpus.
61
+ - HSPC: too rare to judge at these cell numbers.
62
+ 4. **Caveats.**
63
+ - Zero-shot and pseudobulk-conditioned, one seed, marker-rule states.
64
+ - The DRESS samples were training samples.
65
+ - The Kawasaki data are 10x 5′.
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+ - SLE MS1 in observed cSLE (6.5 %) may partly reflect granulocyte contamination; it is not reproduced.
67
+
68
+ ## Ye 2026 sepsis: real bulk, LoRA, held-out donors (2026-10-05; user approved)
69
+
70
+ **Design.**
71
+ - Arms: the pooled, cross-fitted arms of `paired_finetune_intradataset_20260927`. Each of the 82 donors gets 1,500
72
+ cells from the fold model that never trained on it, conditioned on its real PBMC bulk at K = 1,000.
73
+ - Arms scored:
74
+ - zero-shot (`zs__raw`);
75
+ - LoRA with 5, 10, 20 and 40 training pairs (`lora_n*`, nested subsets per fold);
76
+ - LoRA with all 58 training pairs (`real_lora__raw`);
77
+ - zero-shot from the sc pseudobulk (`zs__pseudo`).
78
+ - No new generation.
79
+ - The benchmark's own labels are reused:
80
+ - Each pooled NPZ was streamed from spark-0110 and checked against its pooled receipt sha.
81
+ - It was read out once with the benchmark's Poisson draw (seed 20260916, whole NPZ).
82
+ - Every cell's UMI on the scoring genes reproduces the benchmark's record exactly, for all 7 arms × 123,000 cells.
83
+ - Observed side: all 589,478 cells of the 82 scored donors. Same state rules and depth matching as above.
84
+ - Tool: `tools/sepsis_states.py`. Outputs: `out/sepsis_{summary,contrasts,per_donor}.csv`.
85
+
86
+ **Counts: state cells / parent cells, all 82 donors; observed thinned to each arm's depth.**
87
+
88
+ | state | zero-shot real bulk | LoRA 5 pairs | LoRA 20 pairs | LoRA all 58 pairs | zero-shot sc pseudobulk |
89
+ |---|---|---|---|---|---|
90
+ | **MS1 monocyte (IL1R2+)** gen | 403 / 45,474 | 2,129 / 21,211 | 2,024 / 24,014 | 2,507 / 22,723 | 1,949 / 29,005 |
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+ | observed | 12,363 / 111,269 | 17,344 / 111,269 | 17,768 / 111,269 | 17,348 / 111,269 | 16,859 / 111,269 |
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+ | gen / obs; Spearman over donors | **0.08**; 0.53 | **0.64**; 0.46 | 0.53; 0.44 | **0.71**; 0.57 | 0.44; 0.40 |
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+ | **C1Q-high monocyte** gen | 63 / 45,474 | 669 / 21,211 | 1,023 / 24,014 | 676 / 22,723 | 101 / 29,005 |
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+ | observed | 5,908 / 111,269 | 6,599 / 111,269 | 6,665 / 111,269 | 6,595 / 111,269 | 6,520 / 111,269 |
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+ | gen / obs | **0.03** | 0.53 | **0.71** | 0.50 | 0.06 |
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+ | **Cycling monocyte (Ye)** gen / obs | 0.10 | 0.31 | 0.15 | 0.23 | 0.13 |
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+ | **Plasmablast (label)** gen / obs | 0.39 | 0.41 | 1.04 | 0.76 | 0.46 |
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+ | ISG-high T / Proliferating T (label) gen / obs | 1.74 / 1.96 | 0.39 / 0.62 | 0.52 / 0.75 | 0.57 / 0.78 | 0.60 / 0.70 |
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+ | DN2 / ABC B; granulocyte-like gen / obs | 1.49; 0.24 | 0.42; 0.04 | 0.39; 0.05 | 0.31; 0.07 | 0.18; 0.03 |
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+
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+ **Disease contrasts, LoRA with all 58 pairs** (generated vs observed):
102
+ - MS1:
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+ - adult sepsis 1,627 / 14,056 vs adult HC 2 / 1,543. Observed: 11,187 / 57,131 vs 39 / 8,702.
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+ - paediatric sepsis 554 / 3,325 vs paediatric HC 1 / 524. Observed: 2,557 / 15,430 vs 5 / 4,363.
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+ - All three contrasts keep their direction in every arm.
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+ - C1Q-high:
107
+ - adult sepsis 481 / 14,056 vs adult HC 18 / 1,543. Observed: 3,687 / 57,131 vs 137 / 8,702.
108
+ - paediatric sepsis 122 / 3,325 vs paediatric HC 1 / 524. Observed: 2,294 / 15,430 vs 35 / 4,363.
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+ - Directions are kept from 10 pairs on.
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+ - LoRA with 5 pairs reverses the adult contrast (47 / 1,245 in HC).
111
+ - Zero-shot from pseudobulk loses all three contrasts.
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+ - Cycling monocytes, paediatric: 33 / 3,325 vs 1 / 524. Observed: 1,645 / 15,430 vs 44 / 4,363. The direction is kept
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+ in every LoRA arm but strongly compressed; zero-shot from real bulk loses the adult contrast.
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+ - Plasmablasts:
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+ - adult sepsis 704 / 69,000 vs HC 21 / 10,500. Observed: 3,601 / 310,451 vs 90 / 59,344. Kept.
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+ - The paediatric observed contrast is flat: 2,779 / 98,395 vs 1,000 / 35,572.
117
+
118
+ **Reading.**
119
+ 1. **LoRA on paired donors is what brings the rare monocyte states out.**
120
+ - Zero-shot from real bulk generates MS1 at 0.08× and C1Q-high at 0.03×.
121
+ - Five pairs already lift them to 0.64× and 0.53×.
122
+ - With 10+ pairs the disease directions hold for both.
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+ - Zero-shot from the sc pseudobulk does not get C1Q-high either (0.06×). The gain comes from fine-tuning, not from a
124
+ better condition.
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+ - For Behçet this suggests the 0.10–0.18× after LoRA-3 is a pair-count / cohort-specific limit, not a hard ceiling of
126
+ the generator. The sepsis training donors carry many C1Q-high cells; Behçet LoRA-3 had 3 BD pairs and was scored on
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+ unpaired bulk donors.
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+ 2. **Still compressed with LoRA:**
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+ - cycling monocytes, 0.15–0.31×;
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+ - granulocyte-like cells, ≤ 0.07×;
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+ - DN2 B cells, 0.3–0.4×.
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+ 3. **Zero-shot overshoots the lymphoid activation states** (ISG-high T 1.7×, proliferating T 2.0×). LoRA brings them
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+ below 1×.
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+ 4. **Caveats.**
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+ - Generated depth differs by arm: median library on measured genes is 973 for zero-shot real bulk and about 1,800–2,000
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+ for the others. Observed cells are thinned to each arm's depth, so compare generated vs observed within an arm.
137
+ - Spearman over donors stays moderate (MS1 0.44–0.57; C1Q 0.15–0.32).
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+
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+ ## Files
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+
141
+ - `tools/screen.py`: generated vs observed per state.
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+ - `tools/corpus_states.py`: corpus frequency, using the same rules.
143
+ - `tools/sepsis_states.py`: Ye 2026 sepsis held-out donors (`extract` per arm from a streamed pooled NPZ, `analyze`);
144
+ per-arm marker extracts in `work/sepsis/` (small), logs in `logs/`.
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+ - `tools/states.json`: the state rules.
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+ - Runs were bounded `systemd-run --user` CPU units (MemoryMax 28G, no swap); logs are in `work/`.
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+ - The generated read-out h5ads were copied back from spark-0110 to a scratch directory for the run, sha-checked
148
+ against their `.moved` markers, and deleted afterwards. So were the corpus sample h5ad and the `behcet_c1q_lora3`
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+ corpus sample. The originals remain on spark-0110.
paper-releases/pbisc-diffusion/updates/20261004T174508Z-sepsis-rare-states/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/analyze.err ADDED
@@ -0,0 +1,15 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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+ Traceback (most recent call last):
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+ File "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/rare_states_screen_20261004/tools/sepsis_states.py", line 231, in <module>
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+ sys.exit(main())
4
+ ^^^^^^
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+ File "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/rare_states_screen_20261004/tools/sepsis_states.py", line 224, in main
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+ cmd_analyze(sys.argv[2:])
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+ File "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/rare_states_screen_20261004/tools/sepsis_states.py", line 162, in cmd_analyze
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+ lg = pd.DataFrame({"aifi_l1": g["aifi_l1"], "aifi_l2": g["aifi_l2"]})
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+ ~^^^^^^^^^^^
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+ File "/home/sj_server_1/miniforge3/envs/cxg_corpus/lib/python3.11/site-packages/numpy/lib/_npyio_impl.py", line 257, in __getitem__
11
+ return format.read_array(
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+ ^^^^^^^^^^^^^^^^^^
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+ File "/home/sj_server_1/miniforge3/envs/cxg_corpus/lib/python3.11/site-packages/numpy/lib/_format_impl.py", line 833, in read_array
14
+ raise ValueError("Object arrays cannot be loaded when "
15
+ ValueError: Object arrays cannot be loaded when allow_pickle=False
paper-releases/pbisc-diffusion/updates/20261004T174508Z-sepsis-rare-states/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/analyze.log ADDED
@@ -0,0 +1,422 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ arm state thin gen obs_thinned obs_native_n gen_pct obs_pct gen_over_obs spearman_donors
2
+ zs__raw C1Q-high monocyte (reference) 0.421 63 / 45,474 5,908 / 111,269 6788 0.139 5.310 0.026 0.149
3
+ zs__raw Cycling T/NK 0.419 294 / 54,913 2,232 / 345,949 3461 0.535 0.645 0.830 0.119
4
+ zs__raw Cycling activated T (CD38/HLA-DR) 0.441 168 / 43,347 3,198 / 298,117 5877 0.388 1.073 0.361 0.034
5
+ zs__raw Proliferating T (label) 1.000 1,369 / 43,347 4,793 / 298,117 4793 3.158 1.608 1.964 -0.019
6
+ zs__raw Plasmablast (label) 1.000 678 / 123,000 8,423 / 589,478 8423 0.551 1.429 0.386 0.332
7
+ zs__raw Plasmablast (markers) 0.495 882 / 123,000 15,275 / 589,478 26774 0.717 2.591 0.277 0.376
8
+ zs__raw MS1 monocyte (IL1R2+) 0.421 403 / 45,474 12,363 / 111,269 18712 0.886 11.111 0.080 0.526
9
+ zs__raw Cycling monocyte (Ye 2026) 0.421 103 / 45,474 2,618 / 111,269 4601 0.227 2.353 0.096 0.191
10
+ zs__raw ISG-high monocyte (positive control) 0.421 8,106 / 45,474 11,029 / 111,269 21377 17.826 9.912 1.798 0.496
11
+ zs__raw ISG-high T 0.441 1,144 / 43,347 4,514 / 298,117 10685 2.639 1.514 1.743 0.432
12
+ zs__raw DN2 / ABC B 0.575 710 / 18,316 2,592 / 99,729 4309 3.876 2.599 1.491 0.105
13
+ zs__raw HSPC 0.495 72 / 123,000 629 / 589,478 741 0.059 0.107 0.549 -0.006
14
+ zs__raw Cytotoxic CD4 T 0.619 85 / 15,654 1,767 / 140,213 2091 0.543 1.260 0.431 0.375
15
+ zs__raw Granulocyte-like (LDG) 0.495 321 / 123,000 6,501 / 589,478 14337 0.261 1.103 0.237 0.417
16
+ zs__raw Platelet signal in monocytes (negative control) 0.421 1,308 / 45,474 11,518 / 111,269 23329 2.876 10.351 0.278 0.234
17
+ lora_n5__raw C1Q-high monocyte (reference) 0.821 669 / 21,211 6,599 / 111,269 6788 3.154 5.931 0.532 0.151
18
+ lora_n5__raw Cycling T/NK 0.929 211 / 76,200 3,337 / 345,949 3461 0.277 0.965 0.287 0.117
19
+ lora_n5__raw Cycling activated T (CD38/HLA-DR) 0.914 205 / 71,032 5,521 / 298,117 5877 0.289 1.852 0.156 0.121
20
+ lora_n5__raw Proliferating T (label) 1.000 703 / 71,032 4,793 / 298,117 4793 0.990 1.608 0.616 0.222
21
+ lora_n5__raw Plasmablast (label) 1.000 712 / 123,000 8,423 / 589,478 8423 0.579 1.429 0.405 0.125
22
+ lora_n5__raw Plasmablast (markers) 0.908 998 / 123,000 24,644 / 589,478 26774 0.811 4.181 0.194 0.359
23
+ lora_n5__raw MS1 monocyte (IL1R2+) 0.821 2,129 / 21,211 17,344 / 111,269 18712 10.037 15.587 0.644 0.459
24
+ lora_n5__raw Cycling monocyte (Ye 2026) 0.821 235 / 21,211 4,040 / 111,269 4601 1.108 3.631 0.305 0.144
25
+ lora_n5__raw ISG-high monocyte (positive control) 0.821 1,957 / 21,211 18,652 / 111,269 21377 9.226 16.763 0.550 0.311
26
+ lora_n5__raw ISG-high T 0.914 898 / 71,032 9,772 / 298,117 10685 1.264 3.278 0.386 0.511
27
+ lora_n5__raw DN2 / ABC B 0.915 363 / 21,371 4,005 / 99,729 4309 1.699 4.016 0.423 0.040
28
+ lora_n5__raw HSPC 0.908 107 / 123,000 722 / 589,478 741 0.087 0.122 0.710 -0.003
29
+ lora_n5__raw Cytotoxic CD4 T 0.949 518 / 33,233 2,055 / 140,213 2091 1.559 1.466 1.063 0.555
30
+ lora_n5__raw Granulocyte-like (LDG) 0.908 106 / 123,000 12,971 / 589,478 14337 0.086 2.200 0.039 0.352
31
+ lora_n5__raw Platelet signal in monocytes (negative control) 0.821 2,194 / 21,211 20,099 / 111,269 23329 10.344 18.063 0.573 0.201
32
+ lora_n10__raw C1Q-high monocyte (reference) 0.884 673 / 22,416 6,655 / 111,269 6788 3.002 5.981 0.502 0.190
33
+ lora_n10__raw Cycling T/NK 0.966 176 / 76,060 3,394 / 345,949 3461 0.231 0.981 0.236 0.212
34
+ lora_n10__raw Cycling activated T (CD38/HLA-DR) 0.954 200 / 70,094 5,683 / 298,117 5877 0.285 1.906 0.150 0.236
35
+ lora_n10__raw Proliferating T (label) 1.000 601 / 70,094 4,793 / 298,117 4793 0.857 1.608 0.533 0.297
36
+ lora_n10__raw Plasmablast (label) 1.000 691 / 123,000 8,423 / 589,478 8423 0.562 1.429 0.393 0.163
37
+ lora_n10__raw Plasmablast (markers) 0.942 946 / 123,000 25,453 / 589,478 26774 0.769 4.318 0.178 0.362
38
+ lora_n10__raw MS1 monocyte (IL1R2+) 0.884 2,000 / 22,416 17,844 / 111,269 18712 8.922 16.037 0.556 0.423
39
+ lora_n10__raw Cycling monocyte (Ye 2026) 0.884 153 / 22,416 4,273 / 111,269 4601 0.683 3.840 0.178 0.297
40
+ lora_n10__raw ISG-high monocyte (positive control) 0.884 1,882 / 22,416 19,580 / 111,269 21377 8.396 17.597 0.477 0.425
41
+ lora_n10__raw ISG-high T 0.954 1,035 / 70,094 10,140 / 298,117 10685 1.477 3.401 0.434 0.441
42
+ lora_n10__raw DN2 / ABC B 0.907 377 / 20,791 3,942 / 99,729 4309 1.813 3.953 0.459 0.097
43
+ lora_n10__raw HSPC 0.942 91 / 123,000 733 / 589,478 741 0.074 0.124 0.595 0.119
44
+ lora_n10__raw Cytotoxic CD4 T 0.995 567 / 31,214 2,089 / 140,213 2091 1.816 1.490 1.219 0.584
45
+ lora_n10__raw Granulocyte-like (LDG) 0.942 124 / 123,000 13,503 / 589,478 14337 0.101 2.291 0.044 0.542
46
+ lora_n10__raw Platelet signal in monocytes (negative control) 0.884 2,308 / 22,416 21,268 / 111,269 23329 10.296 19.114 0.539 0.157
47
+ lora_n20__raw C1Q-high monocyte (reference) 0.868 1,023 / 24,014 6,665 / 111,269 6788 4.260 5.990 0.711 0.319
48
+ lora_n20__raw Cycling T/NK 1.000 331 / 73,635 3,461 / 345,949 3461 0.450 1.000 0.449 0.331
49
+ lora_n20__raw Cycling activated T (CD38/HLA-DR) 1.000 344 / 66,642 5,877 / 298,117 5877 0.516 1.971 0.262 0.203
50
+ lora_n20__raw Proliferating T (label) 1.000 803 / 66,642 4,793 / 298,117 4793 1.205 1.608 0.749 0.257
51
+ lora_n20__raw Plasmablast (label) 1.000 1,826 / 123,000 8,423 / 589,478 8423 1.485 1.429 1.039 0.291
52
+ lora_n20__raw Plasmablast (markers) 0.999 2,262 / 123,000 26,759 / 589,478 26774 1.839 4.539 0.405 0.448
53
+ lora_n20__raw MS1 monocyte (IL1R2+) 0.868 2,024 / 24,014 17,768 / 111,269 18712 8.428 15.969 0.528 0.441
54
+ lora_n20__raw Cycling monocyte (Ye 2026) 0.868 134 / 24,014 4,201 / 111,269 4601 0.558 3.776 0.148 0.210
55
+ lora_n20__raw ISG-high monocyte (positive control) 0.868 2,415 / 24,014 19,387 / 111,269 21377 10.057 17.424 0.577 0.612
56
+ lora_n20__raw ISG-high T 1.000 1,238 / 66,642 10,685 / 298,117 10685 1.858 3.584 0.518 0.697
57
+ lora_n20__raw DN2 / ABC B 0.969 332 / 20,402 4,192 / 99,729 4309 1.627 4.203 0.387 0.095
58
+ lora_n20__raw HSPC 0.999 113 / 123,000 741 / 589,478 741 0.092 0.126 0.731 0.054
59
+ lora_n20__raw Cytotoxic CD4 T 1.000 626 / 29,696 2,091 / 140,213 2091 2.108 1.491 1.414 0.669
60
+ lora_n20__raw Granulocyte-like (LDG) 0.999 162 / 123,000 14,326 / 589,478 14337 0.132 2.430 0.054 0.373
61
+ lora_n20__raw Platelet signal in monocytes (negative control) 0.868 2,634 / 24,014 20,934 / 111,269 23329 10.969 18.814 0.583 0.076
62
+ lora_n40__raw C1Q-high monocyte (reference) 0.803 613 / 24,297 6,560 / 111,269 6788 2.523 5.896 0.428 0.205
63
+ lora_n40__raw Cycling T/NK 1.000 399 / 73,105 3,461 / 345,949 3461 0.546 1.000 0.546 0.312
64
+ lora_n40__raw Cycling activated T (CD38/HLA-DR) 1.000 426 / 65,276 5,877 / 298,117 5877 0.653 1.971 0.331 0.148
65
+ lora_n40__raw Proliferating T (label) 1.000 899 / 65,276 4,793 / 298,117 4793 1.377 1.608 0.857 0.379
66
+ lora_n40__raw Plasmablast (label) 1.000 1,263 / 123,000 8,423 / 589,478 8423 1.027 1.429 0.719 0.304
67
+ lora_n40__raw Plasmablast (markers) 0.955 1,706 / 123,000 25,723 / 589,478 26774 1.387 4.364 0.318 0.482
68
+ lora_n40__raw MS1 monocyte (IL1R2+) 0.803 3,317 / 24,297 17,254 / 111,269 18712 13.652 15.507 0.880 0.566
69
+ lora_n40__raw Cycling monocyte (Ye 2026) 0.803 165 / 24,297 4,027 / 111,269 4601 0.679 3.619 0.188 0.079
70
+ lora_n40__raw ISG-high monocyte (positive control) 0.803 2,173 / 24,297 18,312 / 111,269 21377 8.943 16.457 0.543 0.638
71
+ lora_n40__raw ISG-high T 1.000 1,471 / 65,276 10,685 / 298,117 10685 2.254 3.584 0.629 0.703
72
+ lora_n40__raw DN2 / ABC B 0.946 218 / 19,980 4,115 / 99,729 4309 1.091 4.126 0.264 0.140
73
+ lora_n40__raw HSPC 0.955 83 / 123,000 736 / 589,478 741 0.067 0.125 0.540 0.148
74
+ lora_n40__raw Cytotoxic CD4 T 1.000 597 / 28,478 2,091 / 140,213 2091 2.096 1.491 1.406 0.688
75
+ lora_n40__raw Granulocyte-like (LDG) 0.955 231 / 123,000 13,678 / 589,478 14337 0.188 2.320 0.081 0.366
76
+ lora_n40__raw Platelet signal in monocytes (negative control) 0.803 2,583 / 24,297 19,803 / 111,269 23329 10.631 17.797 0.597 0.123
77
+ real_lora__raw C1Q-high monocyte (reference) 0.823 676 / 22,723 6,595 / 111,269 6788 2.975 5.927 0.502 0.223
78
+ real_lora__raw Cycling T/NK 1.000 405 / 75,578 3,461 / 345,949 3461 0.536 1.000 0.536 0.332
79
+ real_lora__raw Cycling activated T (CD38/HLA-DR) 0.996 396 / 67,850 5,861 / 298,117 5877 0.584 1.966 0.297 0.172
80
+ real_lora__raw Proliferating T (label) 1.000 846 / 67,850 4,793 / 298,117 4793 1.247 1.608 0.776 0.386
81
+ real_lora__raw Plasmablast (label) 1.000 1,331 / 123,000 8,423 / 589,478 8423 1.082 1.429 0.757 0.195
82
+ real_lora__raw Plasmablast (markers) 0.957 1,803 / 123,000 25,829 / 589,478 26774 1.466 4.382 0.335 0.427
83
+ real_lora__raw MS1 monocyte (IL1R2+) 0.823 2,507 / 22,723 17,348 / 111,269 18712 11.033 15.591 0.708 0.570
84
+ real_lora__raw Cycling monocyte (Ye 2026) 0.823 189 / 22,723 4,067 / 111,269 4601 0.832 3.655 0.228 0.122
85
+ real_lora__raw ISG-high monocyte (positive control) 0.823 2,332 / 22,723 18,712 / 111,269 21377 10.263 16.817 0.610 0.635
86
+ real_lora__raw ISG-high T 0.996 1,378 / 67,850 10,643 / 298,117 10685 2.031 3.570 0.569 0.699
87
+ real_lora__raw DN2 / ABC B 0.934 249 / 19,896 4,051 / 99,729 4309 1.252 4.062 0.308 0.416
88
+ real_lora__raw HSPC 0.957 61 / 123,000 736 / 589,478 741 0.050 0.125 0.397 0.051
89
+ real_lora__raw Cytotoxic CD4 T 1.000 609 / 30,246 2,091 / 140,213 2091 2.013 1.491 1.350 0.692
90
+ real_lora__raw Granulocyte-like (LDG) 0.957 196 / 123,000 13,736 / 589,478 14337 0.159 2.330 0.068 0.381
91
+ real_lora__raw Platelet signal in monocytes (negative control) 0.823 2,308 / 22,723 20,106 / 111,269 23329 10.157 18.070 0.562 0.094
92
+ zs__pseudo C1Q-high monocyte (reference) 0.770 101 / 29,005 6,520 / 111,269 6788 0.348 5.860 0.059 0.039
93
+ zs__pseudo Cycling T/NK 1.000 496 / 70,188 3,461 / 345,949 3461 0.707 1.000 0.706 0.436
94
+ zs__pseudo Cycling activated T (CD38/HLA-DR) 1.000 420 / 62,189 5,877 / 298,117 5877 0.675 1.971 0.343 0.385
95
+ zs__pseudo Proliferating T (label) 1.000 703 / 62,189 4,793 / 298,117 4793 1.130 1.608 0.703 0.485
96
+ zs__pseudo Plasmablast (label) 1.000 812 / 123,000 8,423 / 589,478 8423 0.660 1.429 0.462 0.488
97
+ zs__pseudo Plasmablast (markers) 1.000 1,101 / 123,000 26,774 / 589,478 26774 0.895 4.542 0.197 0.533
98
+ zs__pseudo MS1 monocyte (IL1R2+) 0.770 1,949 / 29,005 16,859 / 111,269 18712 6.720 15.152 0.443 0.396
99
+ zs__pseudo Cycling monocyte (Ye 2026) 0.770 131 / 29,005 3,898 / 111,269 4601 0.452 3.503 0.129 0.249
100
+ zs__pseudo ISG-high monocyte (positive control) 0.770 3,172 / 29,005 17,832 / 111,269 21377 10.936 16.026 0.682 0.564
101
+ zs__pseudo ISG-high T 1.000 1,346 / 62,189 10,685 / 298,117 10685 2.164 3.584 0.604 0.541
102
+ zs__pseudo DN2 / ABC B 1.000 161 / 20,462 4,309 / 99,729 4309 0.787 4.321 0.182 -0.039
103
+ zs__pseudo HSPC 1.000 344 / 123,000 741 / 589,478 741 0.280 0.126 2.225 -0.090
104
+ zs__pseudo Cytotoxic CD4 T 1.000 761 / 29,849 2,091 / 140,213 2091 2.549 1.491 1.710 0.651
105
+ zs__pseudo Granulocyte-like (LDG) 1.000 79 / 123,000 14,337 / 589,478 14337 0.064 2.432 0.026 0.625
106
+ zs__pseudo Platelet signal in monocytes (negative control) 0.770 1,348 / 29,005 19,111 / 111,269 23329 4.647 17.175 0.271 0.510
107
+ arm state contrast n_a n_b obs_a obs_b gen_a gen_b obs_diff gen_diff same_direction
108
+ zs__raw C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3281 / 57131 105 / 8702 41 / 30375 1 / 2195 5.45 0.08 True
109
+ zs__raw C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2114 / 15430 33 / 4363 10 / 6066 2 / 897 8.48 -0.02 False
110
+ zs__raw C1Q-high monocyte (reference) all sepsis vs all controls 61 21 5395 / 72561 513 / 38708 51 / 36441 12 / 9033 6.12 0.01 True
111
+ zs__raw Cycling T/NK adult sepsis vs adult HC 46 7 807 / 187719 108 / 44192 158 / 27878 18 / 7023 0.32 0.37 True
112
+ zs__raw Cycling T/NK paediatric sepsis vs paediatric HC 15 4 545 / 43733 248 / 24170 80 / 10404 10 / 3500 0.16 0.52 True
113
+ zs__raw Cycling T/NK all sepsis vs all controls 61 21 1352 / 231452 880 / 114497 238 / 38282 56 / 16631 -0.12 0.30 False
114
+ zs__raw Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 1249 / 162485 195 / 33194 107 / 20787 9 / 5978 0.41 0.47 True
115
+ zs__raw Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 659 / 40153 371 / 20916 37 / 8615 3 / 3099 -0.27 0.40 False
116
+ zs__raw Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 1908 / 202638 1290 / 95479 144 / 29402 24 / 13945 -0.32 0.38 False
117
+ zs__raw Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 776 / 20787 74 / 5978 -0.06 2.65 False
118
+ zs__raw Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 399 / 8615 36 / 3099 -0.18 3.77 False
119
+ zs__raw Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 1175 / 29402 194 / 13945 -0.62 2.52 False
120
+ zs__raw Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 342 / 69000 1 / 10500 0.97 0.49 True
121
+ zs__raw Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 299 / 22500 1 / 6000 -0.14 1.31 False
122
+ zs__raw Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 641 / 91500 37 / 31500 0.29 0.58 True
123
+ zs__raw Plasmablast (markers) adult sepsis vs adult HC 46 7 6497 / 310451 442 / 59344 468 / 69000 11 / 10500 1.26 0.57 True
124
+ zs__raw Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 4409 / 98395 2024 / 35572 342 / 22500 10 / 6000 -1.50 1.35 False
125
+ zs__raw Plasmablast (markers) all sepsis vs all controls 61 21 10906 / 408846 4369 / 180632 810 / 91500 72 / 31500 -0.06 0.66 False
126
+ zs__raw MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 8049 / 57131 18 / 8702 331 / 30375 1 / 2195 12.73 0.85 True
127
+ zs__raw MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 1894 / 15430 0 / 4363 54 / 6066 0 / 897 14.19 0.74 True
128
+ zs__raw MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 9943 / 72561 2420 / 38708 385 / 36441 18 / 9033 7.86 0.72 True
129
+ zs__raw Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 1106 / 57131 52 / 8702 72 / 30375 6 / 2195 1.07 -0.03 False
130
+ zs__raw Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1188 / 15430 31 / 4363 22 / 6066 1 / 897 5.31 0.28 True
131
+ zs__raw Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 2294 / 72561 324 / 38708 94 / 36441 9 / 9033 2.04 0.14 True
132
+ zs__raw ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 4859 / 57131 653 / 8702 5219 / 30375 140 / 2195 3.32 12.25 True
133
+ zs__raw ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 3628 / 15430 927 / 4363 1919 / 6066 297 / 897 -7.30 -3.20 True
134
+ zs__raw ISG-high monocyte (positive control) all sepsis vs all controls 61 21 8487 / 72561 2542 / 38708 7138 / 36441 968 / 9033 2.10 7.39 True
135
+ zs__raw ISG-high T adult sepsis vs adult HC 46 7 912 / 162485 146 / 33194 371 / 20787 16 / 5978 0.78 1.34 True
136
+ zs__raw ISG-high T paediatric sepsis vs paediatric HC 15 4 971 / 40153 2166 / 20916 357 / 8615 332 / 3099 -12.31 -6.02 True
137
+ zs__raw ISG-high T all sepsis vs all controls 61 21 1883 / 202638 2631 / 95479 728 / 29402 416 / 13945 -1.74 -0.39 True
138
+ zs__raw DN2 / ABC B adult sepsis vs adult HC 46 7 1148 / 47206 171 / 4301 365 / 7936 46 / 1124 -0.18 0.93 False
139
+ zs__raw DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 802 / 33660 160 / 4954 158 / 5234 33 / 1505 -0.37 1.39 False
140
+ zs__raw DN2 / ABC B all sepsis vs all controls 61 21 1950 / 80866 642 / 18863 523 / 13170 187 / 5146 0.16 0.77 True
141
+ zs__raw HSPC adult sepsis vs adult HC 46 7 336 / 310451 57 / 59344 48 / 69000 1 / 10500 0.01 0.06 True
142
+ zs__raw HSPC paediatric sepsis vs paediatric HC 15 4 138 / 98395 21 / 35572 10 / 22500 3 / 6000 0.08 -0.01 False
143
+ zs__raw HSPC all sepsis vs all controls 61 21 474 / 408846 155 / 180632 58 / 91500 14 / 31500 0.03 0.02 True
144
+ zs__raw Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1076 / 83070 346 / 13845 50 / 6908 12 / 1517 -1.16 0.16 False
145
+ zs__raw Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 60 / 17697 27 / 8125 7 / 3518 4 / 1480 -0.06 0.15 False
146
+ zs__raw Cytotoxic CD4 T all sepsis vs all controls 61 21 1136 / 100767 631 / 39446 57 / 10426 28 / 5228 -1.06 0.15 False
147
+ zs__raw Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 4088 / 310451 446 / 59344 220 / 69000 15 / 10500 0.85 0.18 True
148
+ zs__raw Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 1010 / 98395 96 / 35572 33 / 22500 7 / 6000 0.82 0.03 True
149
+ zs__raw Granulocyte-like (LDG) all sepsis vs all controls 61 21 5098 / 408846 1403 / 180632 253 / 91500 68 / 31500 0.56 0.06 True
150
+ zs__raw Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 6667 / 57131 622 / 8702 983 / 30375 30 / 2195 3.05 1.67 True
151
+ zs__raw Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 1695 / 15430 170 / 4363 151 / 6066 7 / 897 2.95 1.15 True
152
+ zs__raw Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 8362 / 72561 3156 / 38708 1134 / 36441 174 / 9033 2.15 1.00 True
153
+ lora_n5__raw C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3675 / 57131 135 / 8702 449 / 13060 47 / 1245 6.06 -0.47 False
154
+ lora_n5__raw C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2305 / 15430 35 / 4363 121 / 3124 1 / 369 9.32 1.36 True
155
+ lora_n5__raw C1Q-high monocyte (reference) all sepsis vs all controls 61 21 5980 / 72561 619 / 38708 570 / 16184 99 / 5027 6.83 0.40 True
156
+ lora_n5__raw Cycling T/NK adult sepsis vs adult HC 46 7 1176 / 187719 148 / 44192 124 / 43294 14 / 8248 0.49 0.17 True
157
+ lora_n5__raw Cycling T/NK paediatric sepsis vs paediatric HC 15 4 767 / 43733 424 / 24170 40 / 12279 10 / 4045 -0.15 0.17 False
158
+ lora_n5__raw Cycling T/NK all sepsis vs all controls 61 21 1943 / 231452 1394 / 114497 164 / 55573 47 / 20627 -0.33 0.13 False
159
+ lora_n5__raw Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 2243 / 162485 382 / 33194 128 / 40009 15 / 7765 0.47 0.17 True
160
+ lora_n5__raw Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 968 / 40153 705 / 20916 36 / 11571 5 / 3883 -1.28 0.25 False
161
+ lora_n5__raw Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 3211 / 202638 2310 / 95479 164 / 51580 41 / 19452 -0.83 0.15 False
162
+ lora_n5__raw Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 370 / 40009 73 / 7765 -0.06 0.08 False
163
+ lora_n5__raw Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 152 / 11571 40 / 3883 -0.18 0.25 False
164
+ lora_n5__raw Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 522 / 51580 181 / 19452 -0.62 0.18 False
165
+ lora_n5__raw Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 421 / 69000 8 / 10500 0.97 0.53 True
166
+ lora_n5__raw Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 225 / 22500 6 / 6000 -0.14 0.90 False
167
+ lora_n5__raw Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 646 / 91500 66 / 31500 0.29 0.50 True
168
+ lora_n5__raw Plasmablast (markers) adult sepsis vs adult HC 46 7 10765 / 310451 879 / 59344 567 / 69000 19 / 10500 1.78 0.64 True
169
+ lora_n5__raw Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 7003 / 98395 2884 / 35572 316 / 22500 14 / 6000 -1.38 1.17 False
170
+ lora_n5__raw Plasmablast (markers) all sepsis vs all controls 61 21 17768 / 408846 6876 / 180632 883 / 91500 115 / 31500 0.03 0.60 True
171
+ lora_n5__raw MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 11179 / 57131 47 / 8702 1180 / 13060 1 / 1245 17.70 4.36 True
172
+ lora_n5__raw MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 2557 / 15430 7 / 4363 841 / 3124 0 / 369 20.07 10.68 True
173
+ lora_n5__raw MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 13736 / 72561 3608 / 38708 2021 / 16184 108 / 5027 10.66 4.91 True
174
+ lora_n5__raw Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 1858 / 57131 89 / 8702 160 / 13060 2 / 1245 1.95 0.52 True
175
+ lora_n5__raw Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1640 / 15430 43 / 4363 67 / 3124 1 / 369 6.74 0.73 True
176
+ lora_n5__raw Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 3498 / 72561 542 / 38708 227 / 16184 8 / 5027 2.93 0.53 True
177
+ lora_n5__raw ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 8229 / 57131 1401 / 8702 1207 / 13060 30 / 1245 0.94 6.12 True
178
+ lora_n5__raw ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 5616 / 15430 1380 / 4363 544 / 3124 81 / 369 -6.21 -3.77 True
179
+ lora_n5__raw ISG-high monocyte (positive control) all sepsis vs all controls 61 21 13845 / 72561 4807 / 38708 1751 / 16184 206 / 5027 2.07 3.71 True
180
+ lora_n5__raw ISG-high T adult sepsis vs adult HC 46 7 2833 / 162485 483 / 33194 361 / 40009 11 / 7765 1.54 0.88 True
181
+ lora_n5__raw ISG-high T paediatric sepsis vs paediatric HC 15 4 2391 / 40153 3150 / 20916 302 / 11571 196 / 3883 -15.54 -3.45 True
182
+ lora_n5__raw ISG-high T all sepsis vs all controls 61 21 5224 / 202638 4548 / 95479 663 / 51580 235 / 19452 -1.75 0.07 False
183
+ lora_n5__raw DN2 / ABC B adult sepsis vs adult HC 46 7 1672 / 47206 267 / 4301 214 / 9724 26 / 859 -0.80 -0.57 True
184
+ lora_n5__raw DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 1338 / 33660 265 / 4954 82 / 6524 10 / 1542 -0.98 0.84 False
185
+ lora_n5__raw DN2 / ABC B all sepsis vs all controls 61 21 3010 / 80866 995 / 18863 296 / 16248 67 / 5123 -0.11 0.37 False
186
+ lora_n5__raw HSPC adult sepsis vs adult HC 46 7 383 / 310451 67 / 59344 69 / 69000 0 / 10500 0.01 0.10 True
187
+ lora_n5__raw HSPC paediatric sepsis vs paediatric HC 15 4 156 / 98395 26 / 35572 14 / 22500 5 / 6000 0.08 -0.02 False
188
+ lora_n5__raw HSPC all sepsis vs all controls 61 21 539 / 408846 183 / 180632 83 / 91500 24 / 31500 0.03 0.01 True
189
+ lora_n5__raw Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1239 / 83070 406 / 13845 299 / 18428 113 / 3333 -1.37 -2.11 True
190
+ lora_n5__raw Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 69 / 17697 41 / 8125 38 / 5392 15 / 2035 -0.23 -0.10 True
191
+ lora_n5__raw Cytotoxic CD4 T all sepsis vs all controls 61 21 1308 / 100767 747 / 39446 337 / 23820 181 / 9413 -1.16 -0.61 True
192
+ lora_n5__raw Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 7616 / 310451 974 / 59344 63 / 69000 6 / 10500 1.21 0.03 True
193
+ lora_n5__raw Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 2108 / 98395 261 / 35572 16 / 22500 2 / 6000 1.55 0.04 True
194
+ lora_n5__raw Granulocyte-like (LDG) all sepsis vs all controls 61 21 9724 / 408846 3247 / 180632 79 / 91500 27 / 31500 0.70 0.00 True
195
+ lora_n5__raw Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 11026 / 57131 1104 / 8702 1565 / 13060 73 / 1245 4.44 3.93 True
196
+ lora_n5__raw Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 2937 / 15430 425 / 4363 280 / 3124 8 / 369 3.40 5.38 True
197
+ lora_n5__raw Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 13963 / 72561 6136 / 38708 1845 / 16184 349 / 5027 1.96 2.44 True
198
+ lora_n10__raw C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3715 / 57131 138 / 8702 458 / 14253 28 / 1229 6.05 0.18 True
199
+ lora_n10__raw C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2303 / 15430 38 / 4363 140 / 3009 3 / 595 9.28 1.40 True
200
+ lora_n10__raw C1Q-high monocyte (reference) all sepsis vs all controls 61 21 6018 / 72561 637 / 38708 598 / 17262 75 / 5154 6.80 0.33 True
201
+ lora_n10__raw Cycling T/NK adult sepsis vs adult HC 46 7 1184 / 187719 149 / 44192 83 / 42352 22 / 8395 0.49 -0.05 False
202
+ lora_n10__raw Cycling T/NK paediatric sepsis vs paediatric HC 15 4 778 / 43733 447 / 24170 35 / 12638 17 / 4084 -0.23 -0.13 True
203
+ lora_n10__raw Cycling T/NK all sepsis vs all controls 61 21 1962 / 231452 1432 / 114497 118 / 54990 58 / 21070 -0.35 -0.05 True
204
+ lora_n10__raw Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 2315 / 162485 401 / 33194 107 / 38547 24 / 7736 0.46 -0.00 False
205
+ lora_n10__raw Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 986 / 40153 725 / 20916 41 / 11960 10 / 3863 -1.35 0.10 False
206
+ lora_n10__raw Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 3301 / 202638 2382 / 95479 148 / 50507 52 / 19587 -0.87 0.05 False
207
+ lora_n10__raw Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 306 / 38547 74 / 7736 -0.06 -0.16 True
208
+ lora_n10__raw Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 117 / 11960 31 / 3863 -0.18 0.38 False
209
+ lora_n10__raw Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 423 / 50507 178 / 19587 -0.62 -0.07 True
210
+ lora_n10__raw Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 413 / 69000 15 / 10500 0.97 0.46 True
211
+ lora_n10__raw Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 195 / 22500 7 / 6000 -0.14 0.75 False
212
+ lora_n10__raw Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 608 / 91500 83 / 31500 0.29 0.40 True
213
+ lora_n10__raw Plasmablast (markers) adult sepsis vs adult HC 46 7 11086 / 310451 924 / 59344 553 / 69000 27 / 10500 1.80 0.54 True
214
+ lora_n10__raw Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 7281 / 98395 2965 / 35572 259 / 22500 19 / 6000 -1.33 0.83 False
215
+ lora_n10__raw Plasmablast (markers) all sepsis vs all controls 61 21 18367 / 408846 7086 / 180632 812 / 91500 134 / 31500 0.04 0.46 True
216
+ lora_n10__raw MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 11473 / 57131 48 / 8702 1262 / 14253 4 / 1229 18.15 6.62 True
217
+ lora_n10__raw MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 2640 / 15430 6 / 4363 636 / 3009 1 / 595 20.96 10.70 True
218
+ lora_n10__raw MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 14113 / 72561 3731 / 38708 1898 / 17262 102 / 5154 10.92 6.91 True
219
+ lora_n10__raw Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 1979 / 57131 95 / 8702 117 / 14253 1 / 1229 2.04 0.36 True
220
+ lora_n10__raw Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1707 / 15430 49 / 4363 29 / 3009 1 / 595 7.60 0.57 True
221
+ lora_n10__raw Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 3686 / 72561 587 / 38708 146 / 17262 7 / 5154 3.21 0.33 True
222
+ lora_n10__raw ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 8650 / 57131 1507 / 8702 1228 / 14253 38 / 1229 0.54 4.16 True
223
+ lora_n10__raw ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 5839 / 15430 1413 / 4363 412 / 3009 107 / 595 -5.77 -13.01 True
224
+ lora_n10__raw ISG-high monocyte (positive control) all sepsis vs all controls 61 21 14489 / 72561 5091 / 38708 1640 / 17262 242 / 5154 2.00 0.43 True
225
+ lora_n10__raw ISG-high T adult sepsis vs adult HC 46 7 3008 / 162485 498 / 33194 304 / 38547 15 / 7736 1.65 0.63 True
226
+ lora_n10__raw ISG-high T paediatric sepsis vs paediatric HC 15 4 2484 / 40153 3186 / 20916 347 / 11960 334 / 3863 -15.58 -7.14 True
227
+ lora_n10__raw ISG-high T all sepsis vs all controls 61 21 5492 / 202638 4648 / 95479 651 / 50507 384 / 19587 -1.68 -0.84 True
228
+ lora_n10__raw DN2 / ABC B adult sepsis vs adult HC 46 7 1657 / 47206 263 / 4301 210 / 9911 27 / 654 -0.80 -1.98 True
229
+ lora_n10__raw DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 1303 / 33660 261 / 4954 84 / 6386 16 / 1216 -0.91 0.09 False
230
+ lora_n10__raw DN2 / ABC B all sepsis vs all controls 61 21 2960 / 80866 982 / 18863 294 / 16297 83 / 4494 -0.09 -0.42 True
231
+ lora_n10__raw HSPC adult sepsis vs adult HC 46 7 387 / 310451 67 / 59344 62 / 69000 3 / 10500 0.01 0.06 True
232
+ lora_n10__raw HSPC paediatric sepsis vs paediatric HC 15 4 158 / 98395 28 / 35572 6 / 22500 4 / 6000 0.08 -0.04 False
233
+ lora_n10__raw HSPC all sepsis vs all controls 61 21 545 / 408846 188 / 180632 68 / 91500 23 / 31500 0.03 0.00 True
234
+ lora_n10__raw Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1250 / 83070 416 / 13845 312 / 17147 135 / 2701 -1.44 -3.37 True
235
+ lora_n10__raw Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 71 / 17697 44 / 8125 48 / 5504 8 / 1782 -0.25 0.61 False
236
+ lora_n10__raw Cytotoxic CD4 T all sepsis vs all controls 61 21 1321 / 100767 768 / 39446 360 / 22651 207 / 8563 -1.21 -1.00 True
237
+ lora_n10__raw Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 7895 / 310451 1023 / 59344 79 / 69000 5 / 10500 1.22 0.07 True
238
+ lora_n10__raw Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 2215 / 98395 276 / 35572 18 / 22500 0 / 6000 1.63 0.08 True
239
+ lora_n10__raw Granulocyte-like (LDG) all sepsis vs all controls 61 21 10110 / 408846 3393 / 180632 97 / 91500 27 / 31500 0.69 0.02 True
240
+ lora_n10__raw Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 11541 / 57131 1166 / 8702 1636 / 14253 61 / 1229 4.43 4.97 True
241
+ lora_n10__raw Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 3135 / 15430 444 / 4363 314 / 3009 26 / 595 3.94 3.07 True
242
+ lora_n10__raw Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 14676 / 72561 6592 / 38708 1950 / 17262 358 / 5154 1.74 2.33 True
243
+ lora_n20__raw C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3722 / 57131 140 / 8702 724 / 14671 37 / 1552 6.06 2.24 True
244
+ lora_n20__raw C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2308 / 15430 38 / 4363 203 / 3963 4 / 808 9.30 4.30 True
245
+ lora_n20__raw C1Q-high monocyte (reference) all sepsis vs all controls 61 21 6030 / 72561 635 / 38708 927 / 18634 96 / 5380 6.83 2.57 True
246
+ lora_n20__raw Cycling T/NK adult sepsis vs adult HC 46 7 1216 / 187719 151 / 44192 142 / 41366 21 / 7952 0.51 0.12 True
247
+ lora_n20__raw Cycling T/NK paediatric sepsis vs paediatric HC 15 4 784 / 43733 454 / 24170 126 / 11582 17 / 4054 -0.24 0.71 False
248
+ lora_n20__raw Cycling T/NK all sepsis vs all controls 61 21 2000 / 231452 1461 / 114497 268 / 52948 63 / 20687 -0.37 0.25 False
249
+ lora_n20__raw Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 2401 / 162485 422 / 33194 166 / 36958 20 / 7282 0.46 0.24 True
250
+ lora_n20__raw Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 1011 / 40153 751 / 20916 124 / 10698 10 / 3794 -1.42 0.91 False
251
+ lora_n20__raw Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 3412 / 202638 2465 / 95479 290 / 47656 54 / 18986 -0.90 0.37 False
252
+ lora_n20__raw Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 363 / 36958 75 / 7282 -0.06 -0.00 True
253
+ lora_n20__raw Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 253 / 10698 49 / 3794 -0.18 1.23 False
254
+ lora_n20__raw Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 616 / 47656 187 / 18986 -0.62 0.41 False
255
+ lora_n20__raw Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 980 / 69000 11 / 10500 0.97 1.32 True
256
+ lora_n20__raw Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 659 / 22500 10 / 6000 -0.14 2.76 False
257
+ lora_n20__raw Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 1639 / 91500 187 / 31500 0.29 1.20 True
258
+ lora_n20__raw Plasmablast (markers) adult sepsis vs adult HC 46 7 11708 / 310451 990 / 59344 1187 / 69000 28 / 10500 1.88 1.45 True
259
+ lora_n20__raw Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 7672 / 98395 3046 / 35572 807 / 22500 22 / 6000 -1.17 3.22 False
260
+ lora_n20__raw Plasmablast (markers) all sepsis vs all controls 61 21 19380 / 408846 7379 / 180632 1994 / 91500 268 / 31500 0.10 1.33 True
261
+ lora_n20__raw MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 11440 / 57131 46 / 8702 1302 / 14671 5 / 1552 18.02 7.14 True
262
+ lora_n20__raw MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 2616 / 15430 4 / 4363 596 / 3963 4 / 808 20.26 9.00 True
263
+ lora_n20__raw MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 14056 / 72561 3712 / 38708 1898 / 18634 126 / 5380 10.68 6.29 True
264
+ lora_n20__raw Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 1957 / 57131 94 / 8702 90 / 14671 2 / 1552 2.08 0.22 True
265
+ lora_n20__raw Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1669 / 15430 47 / 4363 34 / 3963 4 / 808 7.14 0.25 True
266
+ lora_n20__raw Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 3626 / 72561 575 / 38708 124 / 18634 10 / 5380 3.08 0.20 True
267
+ lora_n20__raw ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 8580 / 57131 1465 / 8702 1281 / 14671 33 / 1552 1.03 5.93 True
268
+ lora_n20__raw ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 5783 / 15430 1395 / 4363 930 / 3963 90 / 808 -5.44 -9.48 True
269
+ lora_n20__raw ISG-high monocyte (positive control) all sepsis vs all controls 61 21 14363 / 72561 5024 / 38708 2211 / 18634 204 / 5380 2.33 2.12 True
270
+ lora_n20__raw ISG-high T adult sepsis vs adult HC 46 7 3234 / 162485 542 / 33194 352 / 36958 16 / 7282 1.70 0.66 True
271
+ lora_n20__raw ISG-high T paediatric sepsis vs paediatric HC 15 4 2623 / 40153 3251 / 20916 417 / 10698 417 / 3794 -15.64 -5.48 True
272
+ lora_n20__raw ISG-high T all sepsis vs all controls 61 21 5857 / 202638 4828 / 95479 769 / 47656 469 / 18986 -1.65 -0.34 True
273
+ lora_n20__raw DN2 / ABC B adult sepsis vs adult HC 46 7 1759 / 47206 274 / 4301 221 / 9669 12 / 646 -0.67 0.15 False
274
+ lora_n20__raw DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 1397 / 33660 281 / 4954 61 / 6386 7 / 978 -1.02 0.39 False
275
+ lora_n20__raw DN2 / ABC B all sepsis vs all controls 61 21 3156 / 80866 1036 / 18863 282 / 16055 50 / 4347 -0.05 0.34 False
276
+ lora_n20__raw HSPC adult sepsis vs adult HC 46 7 391 / 310451 69 / 59344 67 / 69000 7 / 10500 0.01 0.03 True
277
+ lora_n20__raw HSPC paediatric sepsis vs paediatric HC 15 4 159 / 98395 29 / 35572 21 / 22500 6 / 6000 0.08 -0.01 False
278
+ lora_n20__raw HSPC all sepsis vs all controls 61 21 550 / 408846 191 / 180632 88 / 91500 25 / 31500 0.03 0.02 True
279
+ lora_n20__raw Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1249 / 83070 419 / 13845 341 / 16447 150 / 3005 -1.46 -3.08 True
280
+ lora_n20__raw Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 71 / 17697 44 / 8125 48 / 4863 19 / 1601 -0.25 0.05 False
281
+ lora_n20__raw Cytotoxic CD4 T all sepsis vs all controls 61 21 1320 / 100767 771 / 39446 389 / 21310 237 / 8386 -1.22 -0.98 True
282
+ lora_n20__raw Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 8318 / 310451 1094 / 59344 91 / 69000 4 / 10500 1.27 0.09 True
283
+ lora_n20__raw Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 2360 / 98395 299 / 35572 40 / 22500 4 / 6000 1.72 0.11 True
284
+ lora_n20__raw Granulocyte-like (LDG) all sepsis vs all controls 61 21 10678 / 408846 3648 / 180632 131 / 91500 31 / 31500 0.70 0.04 True
285
+ lora_n20__raw Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 11380 / 57131 1164 / 8702 1759 / 14671 114 / 1552 4.46 3.69 True
286
+ lora_n20__raw Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 3082 / 15430 430 / 4363 399 / 3963 50 / 808 3.93 3.39 True
287
+ lora_n20__raw Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 14462 / 72561 6472 / 38708 2158 / 18634 476 / 5380 1.91 2.00 True
288
+ lora_n40__raw C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3667 / 57131 135 / 8702 394 / 14943 25 / 1708 5.79 0.99 True
289
+ lora_n40__raw C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2275 / 15430 39 / 4363 150 / 3429 4 / 642 8.70 2.95 True
290
+ lora_n40__raw C1Q-high monocyte (reference) all sepsis vs all controls 61 21 5942 / 72561 618 / 38708 544 / 18372 69 / 5925 6.50 1.46 True
291
+ lora_n40__raw Cycling T/NK adult sepsis vs adult HC 46 7 1216 / 187719 151 / 44192 161 / 41175 23 / 7912 0.51 0.13 True
292
+ lora_n40__raw Cycling T/NK paediatric sepsis vs paediatric HC 15 4 784 / 43733 454 / 24170 146 / 11516 41 / 4231 -0.24 0.10 False
293
+ lora_n40__raw Cycling T/NK all sepsis vs all controls 61 21 2000 / 231452 1461 / 114497 307 / 52691 92 / 20414 -0.37 0.10 False
294
+ lora_n40__raw Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 2401 / 162485 422 / 33194 182 / 36546 26 / 7008 0.46 0.17 True
295
+ lora_n40__raw Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 1011 / 40153 751 / 20916 164 / 10592 32 / 3757 -1.42 0.42 False
296
+ lora_n40__raw Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 3412 / 202638 2465 / 95479 346 / 47138 80 / 18138 -0.90 0.28 False
297
+ lora_n40__raw Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 407 / 36546 73 / 7008 -0.06 0.10 False
298
+ lora_n40__raw Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 285 / 10592 74 / 3757 -0.18 0.30 False
299
+ lora_n40__raw Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 692 / 47138 207 / 18138 -0.62 0.29 False
300
+ lora_n40__raw Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 634 / 69000 14 / 10500 0.97 0.79 True
301
+ lora_n40__raw Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 514 / 22500 30 / 6000 -0.14 1.78 False
302
+ lora_n40__raw Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 1148 / 91500 115 / 31500 0.29 0.89 True
303
+ lora_n40__raw Plasmablast (markers) adult sepsis vs adult HC 46 7 11212 / 310451 934 / 59344 838 / 69000 32 / 10500 1.82 0.91 True
304
+ lora_n40__raw Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 7357 / 98395 2974 / 35572 674 / 22500 52 / 6000 -1.28 2.13 False
305
+ lora_n40__raw Plasmablast (markers) all sepsis vs all controls 61 21 18569 / 408846 7154 / 180632 1512 / 91500 194 / 31500 0.05 1.04 True
306
+ lora_n40__raw MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 11120 / 57131 47 / 8702 2299 / 14943 6 / 1708 17.45 12.11 True
307
+ lora_n40__raw MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 2538 / 15430 3 / 4363 685 / 3429 2 / 642 18.70 15.02 True
308
+ lora_n40__raw MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 13658 / 72561 3596 / 38708 2984 / 18372 333 / 5925 10.17 10.94 True
309
+ lora_n40__raw Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 1870 / 57131 87 / 8702 112 / 14943 3 / 1708 1.99 0.38 True
310
+ lora_n40__raw Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1618 / 15430 45 / 4363 39 / 3429 3 / 642 7.43 0.80 True
311
+ lora_n40__raw Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 3488 / 72561 539 / 38708 151 / 18372 14 / 5925 3.14 0.50 True
312
+ lora_n40__raw ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 8013 / 57131 1351 / 8702 1076 / 14943 44 / 1708 1.60 5.07 True
313
+ lora_n40__raw ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 5573 / 15430 1364 / 4363 839 / 3429 126 / 642 -5.86 -12.22 True
314
+ lora_n40__raw ISG-high monocyte (positive control) all sepsis vs all controls 61 21 13586 / 72561 4726 / 38708 1915 / 18372 258 / 5925 2.43 1.48 True
315
+ lora_n40__raw ISG-high T adult sepsis vs adult HC 46 7 3234 / 162485 542 / 33194 471 / 36546 19 / 7008 1.70 0.84 True
316
+ lora_n40__raw ISG-high T paediatric sepsis vs paediatric HC 15 4 2623 / 40153 3251 / 20916 370 / 10592 585 / 3757 -15.64 -11.61 True
317
+ lora_n40__raw ISG-high T all sepsis vs all controls 61 21 5857 / 202638 4828 / 95479 841 / 47138 630 / 18138 -1.65 -1.36 True
318
+ lora_n40__raw DN2 / ABC B adult sepsis vs adult HC 46 7 1732 / 47206 272 / 4301 119 / 8888 15 / 548 -0.73 -1.61 True
319
+ lora_n40__raw DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 1358 / 33660 280 / 4954 55 / 6983 11 / 932 -1.11 -0.22 True
320
+ lora_n40__raw DN2 / ABC B all sepsis vs all controls 61 21 3090 / 80866 1025 / 18863 174 / 15871 44 / 4109 -0.10 -0.35 True
321
+ lora_n40__raw HSPC adult sepsis vs adult HC 46 7 390 / 310451 67 / 59344 50 / 69000 7 / 10500 0.01 0.01 True
322
+ lora_n40__raw HSPC paediatric sepsis vs paediatric HC 15 4 157 / 98395 29 / 35572 10 / 22500 2 / 6000 0.07 0.01 True
323
+ lora_n40__raw HSPC all sepsis vs all controls 61 21 547 / 408846 189 / 180632 60 / 91500 23 / 31500 0.03 -0.01 False
324
+ lora_n40__raw Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1249 / 83070 419 / 13845 329 / 16184 164 / 2719 -1.46 -3.95 True
325
+ lora_n40__raw Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 71 / 17697 44 / 8125 40 / 4539 6 / 1504 -0.25 0.80 False
326
+ lora_n40__raw Cytotoxic CD4 T all sepsis vs all controls 61 21 1320 / 100767 771 / 39446 369 / 20723 228 / 7755 -1.22 -1.10 True
327
+ lora_n40__raw Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 7972 / 310451 1032 / 59344 153 / 69000 7 / 10500 1.24 0.16 True
328
+ lora_n40__raw Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 2237 / 98395 285 / 35572 50 / 22500 5 / 6000 1.63 0.14 True
329
+ lora_n40__raw Granulocyte-like (LDG) all sepsis vs all controls 61 21 10209 / 408846 3469 / 180632 203 / 91500 28 / 31500 0.68 0.13 True
330
+ lora_n40__raw Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 10878 / 57131 1068 / 8702 1660 / 14943 98 / 1708 4.59 4.78 True
331
+ lora_n40__raw Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 2916 / 15430 396 / 4363 463 / 3429 42 / 642 4.04 4.82 True
332
+ lora_n40__raw Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 13794 / 72561 6009 / 38708 2123 / 18372 460 / 5925 2.15 3.37 True
333
+ real_lora__raw C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3687 / 57131 137 / 8702 481 / 14056 18 / 1543 6.08 1.89 True
334
+ real_lora__raw C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2294 / 15430 35 / 4363 122 / 3325 1 / 524 9.29 3.12 True
335
+ real_lora__raw C1Q-high monocyte (reference) all sepsis vs all controls 61 21 5981 / 72561 614 / 38708 603 / 17381 73 / 5342 6.85 2.05 True
336
+ real_lora__raw Cycling T/NK adult sepsis vs adult HC 46 7 1216 / 187719 151 / 44192 158 / 42538 28 / 8068 0.51 0.07 True
337
+ real_lora__raw Cycling T/NK paediatric sepsis vs paediatric HC 15 4 784 / 43733 454 / 24170 163 / 11841 31 / 4618 -0.24 0.55 False
338
+ real_lora__raw Cycling T/NK all sepsis vs all controls 61 21 2000 / 231452 1461 / 114497 321 / 54379 84 / 21199 -0.37 0.22 False
339
+ real_lora__raw Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 2389 / 162485 420 / 33194 159 / 37951 24 / 6885 0.46 0.13 True
340
+ real_lora__raw Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 1010 / 40153 751 / 20916 169 / 11014 27 / 4230 -1.43 0.71 False
341
+ real_lora__raw Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 3399 / 202638 2462 / 95479 328 / 48965 68 / 18885 -0.90 0.34 False
342
+ real_lora__raw Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 374 / 37951 78 / 6885 -0.06 0.00 False
343
+ real_lora__raw Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 283 / 11014 57 / 4230 -0.18 0.94 False
344
+ real_lora__raw Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 657 / 48965 189 / 18885 -0.62 0.41 False
345
+ real_lora__raw Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 704 / 69000 21 / 10500 0.97 0.82 True
346
+ real_lora__raw Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 527 / 22500 21 / 6000 -0.14 1.99 False
347
+ real_lora__raw Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 1231 / 91500 100 / 31500 0.29 1.03 True
348
+ real_lora__raw Plasmablast (markers) adult sepsis vs adult HC 46 7 11267 / 310451 955 / 59344 915 / 69000 37 / 10500 1.80 0.97 True
349
+ real_lora__raw Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 7392 / 98395 2978 / 35572 692 / 22500 44 / 6000 -1.26 2.34 False
350
+ real_lora__raw Plasmablast (markers) all sepsis vs all controls 61 21 18659 / 408846 7170 / 180632 1607 / 91500 196 / 31500 0.06 1.13 True
351
+ real_lora__raw MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 11187 / 57131 39 / 8702 1627 / 14056 2 / 1543 17.79 10.88 True
352
+ real_lora__raw MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 2557 / 15430 5 / 4363 554 / 3325 1 / 524 19.88 13.70 True
353
+ real_lora__raw MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 13744 / 72561 3604 / 38708 2181 / 17381 326 / 5342 10.59 8.69 True
354
+ real_lora__raw Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 1877 / 57131 90 / 8702 137 / 14056 2 / 1543 1.86 0.58 True
355
+ real_lora__raw Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1645 / 15430 44 / 4363 33 / 3325 1 / 524 7.03 1.00 True
356
+ real_lora__raw Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 3522 / 72561 545 / 38708 170 / 17381 19 / 5342 2.94 0.48 True
357
+ real_lora__raw ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 8283 / 57131 1412 / 8702 1292 / 14056 54 / 1543 1.16 3.81 True
358
+ real_lora__raw ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 5578 / 15430 1381 / 4363 828 / 3325 74 / 524 -6.21 -12.70 True
359
+ real_lora__raw ISG-high monocyte (positive control) all sepsis vs all controls 61 21 13861 / 72561 4851 / 38708 2120 / 17381 212 / 5342 2.13 0.73 True
360
+ real_lora__raw ISG-high T adult sepsis vs adult HC 46 7 3214 / 162485 538 / 33194 299 / 37951 26 / 6885 1.69 0.45 True
361
+ real_lora__raw ISG-high T paediatric sepsis vs paediatric HC 15 4 2616 / 40153 3245 / 20916 413 / 11014 604 / 4230 -15.62 -7.75 True
362
+ real_lora__raw ISG-high T all sepsis vs all controls 61 21 5830 / 202638 4813 / 95479 712 / 48965 666 / 18885 -1.65 -0.92 True
363
+ real_lora__raw DN2 / ABC B adult sepsis vs adult HC 46 7 1703 / 47206 266 / 4301 138 / 9133 23 / 564 -0.83 -2.28 True
364
+ real_lora__raw DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 1342 / 33660 275 / 4954 55 / 6769 15 / 702 -1.18 -1.46 True
365
+ real_lora__raw DN2 / ABC B all sepsis vs all controls 61 21 3045 / 80866 1006 / 18863 193 / 15902 56 / 3994 -0.17 -0.73 True
366
+ real_lora__raw HSPC adult sepsis vs adult HC 46 7 386 / 310451 69 / 59344 30 / 69000 11 / 10500 0.00 -0.06 False
367
+ real_lora__raw HSPC paediatric sepsis vs paediatric HC 15 4 159 / 98395 29 / 35572 8 / 22500 1 / 6000 0.08 0.02 True
368
+ real_lora__raw HSPC all sepsis vs all controls 61 21 545 / 408846 191 / 180632 38 / 91500 23 / 31500 0.03 -0.03 False
369
+ real_lora__raw Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1249 / 83070 419 / 13845 356 / 17362 151 / 2655 -1.46 -3.62 True
370
+ real_lora__raw Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 71 / 17697 44 / 8125 26 / 4716 8 / 1677 -0.25 0.17 False
371
+ real_lora__raw Cytotoxic CD4 T all sepsis vs all controls 61 21 1320 / 100767 771 / 39446 382 / 22078 227 / 8168 -1.22 -1.19 True
372
+ real_lora__raw Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 8011 / 310451 1036 / 59344 118 / 69000 13 / 10500 1.25 0.05 True
373
+ real_lora__raw Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 2257 / 98395 283 / 35572 57 / 22500 2 / 6000 1.66 0.22 True
374
+ real_lora__raw Granulocyte-like (LDG) all sepsis vs all controls 61 21 10268 / 408846 3468 / 180632 175 / 91500 21 / 31500 0.69 0.12 True
375
+ real_lora__raw Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 11002 / 57131 1099 / 8702 1521 / 14056 111 / 1543 4.53 3.32 True
376
+ real_lora__raw Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 2966 / 15430 376 / 4363 309 / 3325 35 / 524 4.55 1.97 True
377
+ real_lora__raw Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 13968 / 72561 6138 / 38708 1830 / 17381 478 / 5342 2.16 2.21 True
378
+ zs__pseudo C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3642 / 57131 129 / 8702 76 / 17048 3 / 1429 6.06 -0.12 False
379
+ zs__pseudo C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2271 / 15430 37 / 4363 16 / 4223 2 / 701 9.13 -0.02 False
380
+ zs__pseudo C1Q-high monocyte (reference) all sepsis vs all controls 61 21 5913 / 72561 607 / 38708 92 / 21271 9 / 7734 6.77 -0.00 False
381
+ zs__pseudo Cycling T/NK adult sepsis vs adult HC 46 7 1216 / 187719 151 / 44192 299 / 41055 24 / 8349 0.51 0.65 True
382
+ zs__pseudo Cycling T/NK paediatric sepsis vs paediatric HC 15 4 784 / 43733 454 / 24170 112 / 9591 20 / 4103 -0.24 0.70 False
383
+ zs__pseudo Cycling T/NK all sepsis vs all controls 61 21 2000 / 231452 1461 / 114497 411 / 50646 85 / 19542 -0.37 0.50 False
384
+ zs__pseudo Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 2401 / 162485 422 / 33194 273 / 36821 17 / 6785 0.46 0.67 True
385
+ zs__pseudo Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 1011 / 40153 751 / 20916 86 / 8793 15 / 3670 -1.42 0.60 False
386
+ zs__pseudo Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 3412 / 202638 2465 / 95479 359 / 45614 61 / 16575 -0.90 0.55 False
387
+ zs__pseudo Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 429 / 36821 45 / 6785 -0.06 0.80 False
388
+ zs__pseudo Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 151 / 8793 24 / 3670 -0.18 1.05 False
389
+ zs__pseudo Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 580 / 45614 123 / 16575 -0.62 0.74 False
390
+ zs__pseudo Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 471 / 69000 8 / 10500 0.97 0.61 True
391
+ zs__pseudo Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 239 / 22500 20 / 6000 -0.14 0.73 False
392
+ zs__pseudo Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 710 / 91500 102 / 31500 0.29 0.45 True
393
+ zs__pseudo Plasmablast (markers) adult sepsis vs adult HC 46 7 11716 / 310451 991 / 59344 627 / 69000 13 / 10500 1.88 0.78 True
394
+ zs__pseudo Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 7674 / 98395 3047 / 35572 330 / 22500 34 / 6000 -1.18 0.90 False
395
+ zs__pseudo Plasmablast (markers) all sepsis vs all controls 61 21 19390 / 408846 7384 / 180632 957 / 91500 144 / 31500 0.10 0.59 True
396
+ zs__pseudo MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 10864 / 57131 40 / 8702 1242 / 17048 2 / 1429 17.06 3.58 True
397
+ zs__pseudo MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 2495 / 15430 5 / 4363 478 / 4223 1 / 701 19.71 5.52 True
398
+ zs__pseudo MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 13359 / 72561 3500 / 38708 1720 / 21271 229 / 7734 10.24 2.65 True
399
+ zs__pseudo Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 1793 / 57131 89 / 8702 76 / 17048 1 / 1429 1.88 0.30 True
400
+ zs__pseudo Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1599 / 15430 42 / 4363 40 / 4223 2 / 701 7.00 0.53 True
401
+ zs__pseudo Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 3392 / 72561 506 / 38708 116 / 21271 15 / 7734 2.99 0.27 True
402
+ zs__pseudo ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 7880 / 57131 1299 / 8702 1910 / 17048 25 / 1429 1.84 7.09 True
403
+ zs__pseudo ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 5377 / 15430 1335 / 4363 913 / 4223 167 / 701 -6.52 -11.61 True
404
+ zs__pseudo ISG-high monocyte (positive control) all sepsis vs all controls 61 21 13257 / 72561 4575 / 38708 2823 / 21271 349 / 7734 2.31 2.37 True
405
+ zs__pseudo ISG-high T adult sepsis vs adult HC 46 7 3234 / 162485 542 / 33194 296 / 36821 16 / 6785 1.70 0.80 True
406
+ zs__pseudo ISG-high T paediatric sepsis vs paediatric HC 15 4 2623 / 40153 3251 / 20916 421 / 8793 582 / 3670 -15.64 -11.57 True
407
+ zs__pseudo ISG-high T all sepsis vs all controls 61 21 5857 / 202638 4828 / 95479 717 / 45614 629 / 16575 -1.65 -1.44 True
408
+ zs__pseudo DN2 / ABC B adult sepsis vs adult HC 46 7 1804 / 47206 286 / 4301 97 / 8854 4 / 488 -0.84 -0.04 True
409
+ zs__pseudo DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 1435 / 33660 291 / 4954 45 / 8201 6 / 1085 -1.18 0.54 False
410
+ zs__pseudo DN2 / ABC B all sepsis vs all controls 61 21 3239 / 80866 1070 / 18863 142 / 17055 19 / 3407 -0.13 0.27 False
411
+ zs__pseudo HSPC adult sepsis vs adult HC 46 7 391 / 310451 69 / 59344 197 / 69000 7 / 10500 0.01 0.22 True
412
+ zs__pseudo HSPC paediatric sepsis vs paediatric HC 15 4 159 / 98395 29 / 35572 97 / 22500 8 / 6000 0.08 0.30 True
413
+ zs__pseudo HSPC all sepsis vs all controls 61 21 550 / 408846 191 / 180632 294 / 91500 50 / 31500 0.03 0.16 True
414
+ zs__pseudo Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1249 / 83070 419 / 13845 515 / 17804 99 / 2189 -1.46 -0.40 True
415
+ zs__pseudo Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 71 / 17697 44 / 8125 68 / 4782 25 / 1938 -0.25 0.41 False
416
+ zs__pseudo Cytotoxic CD4 T all sepsis vs all controls 61 21 1320 / 100767 771 / 39446 583 / 22586 178 / 7263 -1.22 0.76 False
417
+ zs__pseudo Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 8326 / 310451 1095 / 59344 52 / 69000 1 / 10500 1.27 0.07 True
418
+ zs__pseudo Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 2362 / 98395 299 / 35572 11 / 22500 2 / 6000 1.72 0.02 True
419
+ zs__pseudo Granulocyte-like (LDG) all sepsis vs all controls 61 21 10688 / 408846 3649 / 180632 63 / 91500 16 / 31500 0.70 0.02 True
420
+ zs__pseudo Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 10500 / 57131 1043 / 8702 891 / 17048 34 / 1429 4.41 2.40 True
421
+ zs__pseudo Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 2815 / 15430 372 / 4363 214 / 4223 12 / 701 4.42 2.60 True
422
+ zs__pseudo Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 13315 / 72561 5796 / 38708 1105 / 21271 243 / 7734 2.23 1.79 True
paper-releases/pbisc-diffusion/updates/20261004T174508Z-sepsis-rare-states/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/extract_lora_n10__raw.err ADDED
File without changes