Archive 4 checkpoints (1-4)
Browse files- paper-releases/pbisc-diffusion/updates/20261012T143729Z-strictpairs-recovery-two-host/diffusion/dataset/server_1/model8/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/SOURCE_MAP.json +167 -0
- paper-releases/pbisc-diffusion/updates/20261012T143729Z-strictpairs-recovery-two-host/diffusion/dataset/server_1/model8/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/32/prepare_draw_inputs.py +320 -0
- paper-releases/pbisc-diffusion/updates/20261012T143729Z-strictpairs-recovery-two-host/diffusion/dataset/server_1/model8/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/archive_queue/ARCHIVE_RECOVERY_QUEUE.json +14 -0
- paper-releases/pbisc-diffusion/updates/20261012T143729Z-strictpairs-recovery-two-host/diffusion/dataset/server_1/model8/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/archive_queue/finish_recovery_archives.py +60 -0
paper-releases/pbisc-diffusion/updates/20261012T143729Z-strictpairs-recovery-two-host/diffusion/dataset/server_1/model8/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/SOURCE_MAP.json
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[
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{
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"snapshot": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/22/immicro-healthy-fold0-n5-train.json",
|
| 115 |
+
"sha256": "a5adc14fe5a2bce4f9aaaaae6a3cfa087e13f91ba8bf7972eb937f1508cf3714"
|
| 116 |
+
},
|
| 117 |
+
{
|
| 118 |
+
"original": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/recoveries/source_reuse_20261012/immicro-healthy-fold1-n5-scinputs-proof.json",
|
| 119 |
+
"snapshot": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/23/immicro-healthy-fold1-n5-scinputs-proof.json",
|
| 120 |
+
"sha256": "482e5417167f4f67b0bc00d4ed1cc1972fa4602757b700767cd1d881485e89e0"
|
| 121 |
+
},
|
| 122 |
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{
|
| 123 |
+
"original": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/recoveries/source_reuse_20261012/immicro-healthy-fold1-n5-scinputs.json",
|
| 124 |
+
"snapshot": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/24/immicro-healthy-fold1-n5-scinputs.json",
|
| 125 |
+
"sha256": "feeeef8b6e7a120c879344084e58b646f2c590b693895dba0313d0fadb5cd278"
|
| 126 |
+
},
|
| 127 |
+
{
|
| 128 |
+
"original": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/recoveries/source_reuse_20261012/immicro-healthy-fold0-n5-scinputs.json",
|
| 129 |
+
"snapshot": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/25/immicro-healthy-fold0-n5-scinputs.json",
|
| 130 |
+
"sha256": "2888679e086cfd188852113c98c28fba592220a109223c78fba5cf56392a3b8c"
|
| 131 |
+
},
|
| 132 |
+
{
|
| 133 |
+
"original": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/isolated/immicro/healthy/fold0/n5/REPLAY.json",
|
| 134 |
+
"snapshot": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/26/REPLAY.json",
|
| 135 |
+
"sha256": "bdb8576d6558943f4886c3fe063445a129a4c2c04a3adb8d11bfb869f04c8c82"
|
| 136 |
+
},
|
| 137 |
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{
|
| 138 |
+
"original": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/isolated/immicro/healthy/fold1/n5/REPLAY.json",
|
| 139 |
+
"snapshot": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/27/REPLAY.json",
|
| 140 |
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"sha256": "baa4653814d2a151ab0f55830e57b4a6a30d47edcecebaefb727c968cb495609"
|
| 141 |
+
},
|
| 142 |
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{
|
| 143 |
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"original": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/isolated/immicro/healthy/fold0/n5/ISOLATION.json",
|
| 144 |
+
"snapshot": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/28/ISOLATION.json",
|
| 145 |
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"sha256": "aa3e1cafad1d953458a459522aa2395b673e864caa8829bc514db04b272b831c"
|
| 146 |
+
},
|
| 147 |
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{
|
| 148 |
+
"original": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/isolated/immicro/healthy/fold1/n5/ISOLATION.json",
|
| 149 |
+
"snapshot": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/29/ISOLATION.json",
|
| 150 |
+
"sha256": "0a50a995963f589387a27142c14cc2933c216899e89f794f8bd1e47bff1334db"
|
| 151 |
+
},
|
| 152 |
+
{
|
| 153 |
+
"original": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/backups/recovery_input_isolation_20261012T142024Z/plans/paper_figures_strictpairs_20261012/tools/support_input_isolation.py",
|
| 154 |
+
"snapshot": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/30/support_input_isolation.py",
|
| 155 |
+
"sha256": "1e383c79085c6d20afd839b401ec2e321df3d535d3d1b5552ba9f0e59ba033af"
|
| 156 |
+
},
|
| 157 |
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{
|
| 158 |
+
"original": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/backups/recovery_input_isolation_20261012T142024Z/plans/paired_finetune_intradataset_20260927/tools/ft_sdd.py",
|
| 159 |
+
"snapshot": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/31/ft_sdd.py",
|
| 160 |
+
"sha256": "e7f3d38b65932ffe99292a8841a15eb9e7cce205afec1de6b34b59a06731b82d"
|
| 161 |
+
},
|
| 162 |
+
{
|
| 163 |
+
"original": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/backups/recovery_input_isolation_20261012T142024Z/plans/paired_finetune_intradataset_20260927/scsemi/tools/prepare_draw_inputs.py",
|
| 164 |
+
"snapshot": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/32/prepare_draw_inputs.py",
|
| 165 |
+
"sha256": "b11b9f206a04fdac99dc489a8387647f0a334a59d5761a0c1bd964301933da8f"
|
| 166 |
+
}
|
| 167 |
+
]
|
paper-releases/pbisc-diffusion/updates/20261012T143729Z-strictpairs-recovery-two-host/diffusion/dataset/server_1/model8/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/32/prepare_draw_inputs.py
ADDED
|
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|
| 1 |
+
#!/usr/bin/env python
|
| 2 |
+
"""Build scSemiProfiler inputs for one paired split (CPU only).
|
| 3 |
+
|
| 4 |
+
Representatives = every usable row of the split's training donors (paired sc + real bulk).
|
| 5 |
+
Targets = the split's test rows (real bulk only; their cells are never read here).
|
| 6 |
+
|
| 7 |
+
--mode fewshot --draw j : training donors = data/<ds>/fewshot_n5/draw<j>/train_donors.txt,
|
| 8 |
+
targets = draw<j>/test_samples.txt, condition = draw<j>/test_raw.npz
|
| 9 |
+
--mode cv --fold k : training donors = every usable donor not in fold k (inner-val donors included),
|
| 10 |
+
targets = fold k's rows, condition = data/<ds>/fold<k>/test_raw.npz
|
| 11 |
+
--mode budget --fold k --n N (added 2026-10-02): representatives = exactly the rows LoRA lora_n<N> of fold k saw,
|
| 12 |
+
runs/<ds>/fold<k>/lora_n<N>/RUN.json train_rows + inner_val_rows (checked against
|
| 13 |
+
data/<ds>/CAL_BUDGET.json fit_sample_ids when present); targets = fold k's rows (checked
|
| 14 |
+
against the run's test_rows_never_loaded_for_training); condition = fold<k>/test_raw.npz.
|
| 15 |
+
The manifest also records target_donors (used by run_scsemi_paired.py --reuse-from).
|
| 16 |
+
--check-only (added 2026-10-02): build and check everything (split, genes, cells, depth, condition), write
|
| 17 |
+
nothing under --work; print the summary (and the representative / target lists to
|
| 18 |
+
--check-out if given). Without it the builder behaves exactly as before.
|
| 19 |
+
|
| 20 |
+
Modeled genes = final 6k panel genes measured in the bulk of every representative and target row AND in the
|
| 21 |
+
single cells of every representative row (features.npz bulk_valid / sc_valid). No target single-cell mask,
|
| 22 |
+
depth or cell count enters.
|
| 23 |
+
|
| 24 |
+
Writes <work>/inputs/:
|
| 25 |
+
bulk.h5ad raw bulk counts (float64) of reps + targets on the modeled genes, obs['sample_ids'],
|
| 26 |
+
rows in features.npz order; upstream initsetup(normed=False) library-normalises + log1p's it
|
| 27 |
+
rep_sc.h5ad raw UMI counts (float32 CSR) of every representative cell on the modeled genes,
|
| 28 |
+
obs['sample_ids'] = the representative row's sample id; upstream scprocess(normed=False)
|
| 29 |
+
inputs_manifest.json rows, genes, depth rule, source hashes
|
| 30 |
+
"""
|
| 31 |
+
from __future__ import annotations
|
| 32 |
+
|
| 33 |
+
import argparse
|
| 34 |
+
import hashlib
|
| 35 |
+
import json
|
| 36 |
+
import os
|
| 37 |
+
import sys
|
| 38 |
+
from datetime import datetime, timezone
|
| 39 |
+
from pathlib import Path
|
| 40 |
+
|
| 41 |
+
if os.environ.get("CUDA_VISIBLE_DEVICES") != "":
|
| 42 |
+
raise SystemExit("run with CUDA_VISIBLE_DEVICES=''")
|
| 43 |
+
|
| 44 |
+
import numpy as np
|
| 45 |
+
import pandas as pd
|
| 46 |
+
import scipy.sparse as sp
|
| 47 |
+
|
| 48 |
+
TASK = Path("/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_finetune_intradataset_20260927")
|
| 49 |
+
HERE = TASK / "scsemi"
|
| 50 |
+
sys.path.insert(0, str(TASK / "tools"))
|
| 51 |
+
import prepare_dataset as PD # noqa: E402 (the benchmark's own loader: bulk_raw with unmeasured NaN -> 0, masks, use)
|
| 52 |
+
|
| 53 |
+
SEED = 20260927
|
| 54 |
+
|
| 55 |
+
|
| 56 |
+
def sha(path: Path) -> str:
|
| 57 |
+
h = hashlib.sha256()
|
| 58 |
+
with open(path, "rb") as f:
|
| 59 |
+
for block in iter(lambda: f.read(1 << 24), b""):
|
| 60 |
+
h.update(block)
|
| 61 |
+
return h.hexdigest()
|
| 62 |
+
|
| 63 |
+
|
| 64 |
+
def split_rows(ds: str, mode: str, j: int, sample_ids: np.ndarray, folds: pd.DataFrame,
|
| 65 |
+
n: int | None = None, support_manifest: Path | None = None) -> dict:
|
| 66 |
+
data = TASK / "data" / ds
|
| 67 |
+
usable = folds["fold"].to_numpy() >= 0
|
| 68 |
+
donors = folds["donor_id"].astype(str).to_numpy()
|
| 69 |
+
extra = {}
|
| 70 |
+
if support_manifest is not None:
|
| 71 |
+
strict_tools = TASK.parents[1] / "plans/paper_figures_strictpairs_20261012/tools"
|
| 72 |
+
sys.path.insert(0, str(strict_tools))
|
| 73 |
+
from support_manifest import load_manifest, select_rows
|
| 74 |
+
m = load_manifest(support_manifest, folds)
|
| 75 |
+
if m["cohort"] != ds:
|
| 76 |
+
raise SystemExit("support cohort differs from dataset")
|
| 77 |
+
rep, tgt = select_rows(m, folds)
|
| 78 |
+
rel = support_manifest.resolve().parent.relative_to(
|
| 79 |
+
TASK.parents[1] / "plans/paper_figures_strictpairs_20261012/protocol/splits")
|
| 80 |
+
cond = TASK.parents[1] / "plans/paper_figures_strictpairs_20261012/data" / rel / "test_raw.npz"
|
| 81 |
+
return {"rep": rep, "tgt": tgt, "train_donors": m["train_donor_ids"],
|
| 82 |
+
"test": m["test_sample_ids"], "condition": cond,
|
| 83 |
+
"sources": {"support.json": support_manifest},
|
| 84 |
+
"support_sha256": m["sha256"], "target_donors": m["test_donor_ids"]}
|
| 85 |
+
if mode == "fewshot":
|
| 86 |
+
dd = data / "fewshot_n5" / f"draw{j}"
|
| 87 |
+
train_donors = [x.strip() for x in (dd / "train_donors.txt").read_text().splitlines() if x.strip()]
|
| 88 |
+
test = [x.strip() for x in (dd / "test_samples.txt").read_text().splitlines() if x.strip()]
|
| 89 |
+
cond = dd / "test_raw.npz"
|
| 90 |
+
sources = {"train_donors.txt": dd / "train_donors.txt", "test_samples.txt": dd / "test_samples.txt"}
|
| 91 |
+
rep = np.flatnonzero(np.isin(donors, train_donors) & usable)
|
| 92 |
+
elif mode == "cv":
|
| 93 |
+
fold = folds["fold"].to_numpy()
|
| 94 |
+
test = sample_ids[fold == j].tolist()
|
| 95 |
+
rep = np.flatnonzero(usable & (fold != j))
|
| 96 |
+
train_donors = sorted(set(donors[rep]))
|
| 97 |
+
cond = data / f"fold{j}" / "test_raw.npz"
|
| 98 |
+
sources = {}
|
| 99 |
+
elif mode == "budget":
|
| 100 |
+
fold = folds["fold"].to_numpy()
|
| 101 |
+
rj = TASK / "runs" / ds / f"fold{j}" / f"lora_n{n}" / "RUN.json"
|
| 102 |
+
run = json.loads(rj.read_text())
|
| 103 |
+
if run["fold"] != j or (run.get("train_subset") or {}).get("train_n") != n:
|
| 104 |
+
raise SystemExit(f"{rj}: not the fold {j} n={n} learning-curve run")
|
| 105 |
+
fit = list(run["train_rows"]) + list(run["inner_val_rows"])
|
| 106 |
+
test = sample_ids[fold == j].tolist()
|
| 107 |
+
if sorted(run["test_rows_never_loaded_for_training"]) != sorted(test):
|
| 108 |
+
raise SystemExit(f"{rj}: its test rows differ from fold {j}'s rows")
|
| 109 |
+
pos = {s: i for i, s in enumerate(sample_ids)}
|
| 110 |
+
if len(set(fit)) != len(fit) or any(s not in pos for s in fit):
|
| 111 |
+
raise SystemExit(f"{rj}: duplicate or unknown fit rows")
|
| 112 |
+
rep = np.asarray(sorted(pos[s] for s in fit), dtype=np.int64)
|
| 113 |
+
if not (usable[rep] & (fold[rep] != j)).all():
|
| 114 |
+
raise SystemExit(f"{rj}: a fit row is unusable or in fold {j}")
|
| 115 |
+
cb = data / "CAL_BUDGET.json"
|
| 116 |
+
if cb.exists():
|
| 117 |
+
e = json.loads(cb.read_text())["folds"][str(j)]["n"][str(n)]
|
| 118 |
+
if sorted(e["fit_sample_ids"]) != sorted(fit) or e["lora_checkpoint_sha256"] != run["checkpoint_sha256"]:
|
| 119 |
+
raise SystemExit(f"{cb}: fold {j} n={n} fit rows / LoRA checkpoint differ from {rj}")
|
| 120 |
+
train_donors = sorted(set(donors[rep]))
|
| 121 |
+
cond = data / f"fold{j}" / "test_raw.npz"
|
| 122 |
+
sources = {"lora_RUN.json": rj, **({"CAL_BUDGET.json": cb} if cb.exists() else {})}
|
| 123 |
+
extra = {"budget": {"n": int(n), "fold": int(j), "lora_run": str(rj), "lora_checkpoint_sha256": run["checkpoint_sha256"],
|
| 124 |
+
"n_train_rows": len(run["train_rows"]), "n_inner_val_rows": len(run["inner_val_rows"]),
|
| 125 |
+
"train_rows": list(run["train_rows"]), "inner_val_rows": list(run["inner_val_rows"])}}
|
| 126 |
+
else:
|
| 127 |
+
raise SystemExit(f"unknown mode {mode}")
|
| 128 |
+
pos = {s: i for i, s in enumerate(sample_ids)}
|
| 129 |
+
miss = [s for s in test if s not in pos]
|
| 130 |
+
if miss:
|
| 131 |
+
raise SystemExit(f"test samples not in features.npz: {miss[:5]}")
|
| 132 |
+
tgt = np.asarray([pos[s] for s in test], dtype=np.int64)
|
| 133 |
+
if not usable[tgt].all():
|
| 134 |
+
raise SystemExit("a test row is not usable (fold -1)")
|
| 135 |
+
if set(donors[rep]) & set(donors[tgt]):
|
| 136 |
+
raise SystemExit("a donor is both representative and target")
|
| 137 |
+
if len(set(test)) != len(test):
|
| 138 |
+
raise SystemExit("duplicate test samples")
|
| 139 |
+
return {"rep": rep, "tgt": tgt, "train_donors": train_donors, "test": test, "condition": cond, "sources": sources,
|
| 140 |
+
**extra}
|
| 141 |
+
|
| 142 |
+
|
| 143 |
+
def main(argv=None) -> int:
|
| 144 |
+
ap = argparse.ArgumentParser(description=__doc__, formatter_class=argparse.RawDescriptionHelpFormatter)
|
| 145 |
+
ap.add_argument("--dataset", required=True)
|
| 146 |
+
ap.add_argument("--mode", choices=["fewshot", "cv", "budget"], default="fewshot")
|
| 147 |
+
ap.add_argument("--draw", type=int, help="fewshot draw index")
|
| 148 |
+
ap.add_argument("--fold", type=int, help="cv / budget fold index")
|
| 149 |
+
ap.add_argument("--n", type=int, help="budget: the LoRA learning-curve n (runs/<ds>/fold<k>/lora_n<n>)")
|
| 150 |
+
ap.add_argument("--work", type=Path, required=True)
|
| 151 |
+
ap.add_argument("--smoke-reps", type=int, default=0, help="SMOKE ONLY: keep the first N representative rows")
|
| 152 |
+
ap.add_argument("--smoke-cells", type=int, default=0, help="SMOKE ONLY: at most N cells per representative")
|
| 153 |
+
ap.add_argument("--smoke-targets", default="", help="SMOKE ONLY: comma list of target sample ids")
|
| 154 |
+
ap.add_argument("--smoke-rep-ids", default="", help="SMOKE ONLY: comma list of representative sample ids to keep")
|
| 155 |
+
ap.add_argument("--check-only", action="store_true", help="dry run: check everything, write nothing under --work")
|
| 156 |
+
ap.add_argument("--check-out", type=Path, default=None, help="--check-only: write the split summary JSON here")
|
| 157 |
+
ap.add_argument("--support-manifest", type=Path, default=None,
|
| 158 |
+
help="strict support.json; representatives are its exact n sample IDs")
|
| 159 |
+
a = ap.parse_args(argv)
|
| 160 |
+
if a.support_manifest is not None:
|
| 161 |
+
if a.draw is not None or a.fold is not None or a.n is not None:
|
| 162 |
+
raise SystemExit("--support-manifest cannot be combined with --draw/--fold/--n")
|
| 163 |
+
a.mode = "strict"
|
| 164 |
+
j = 0
|
| 165 |
+
else:
|
| 166 |
+
j = a.draw if a.mode == "fewshot" else a.fold
|
| 167 |
+
if j is None:
|
| 168 |
+
raise SystemExit("--draw (fewshot) or --fold (cv, budget) required")
|
| 169 |
+
if (a.mode == "budget") != (a.n is not None):
|
| 170 |
+
raise SystemExit("--n is required with --mode budget and only valid there")
|
| 171 |
+
smoke = bool(a.smoke_reps or a.smoke_cells or a.smoke_targets or a.smoke_rep_ids)
|
| 172 |
+
if a.support_manifest is not None and smoke:
|
| 173 |
+
raise SystemExit("strict support forbids smoke subsetting")
|
| 174 |
+
work = a.work.resolve()
|
| 175 |
+
if smoke and "/scsemi/smoke/" not in str(work) + "/":
|
| 176 |
+
raise SystemExit("smoke subsetting only under scsemi/smoke/")
|
| 177 |
+
out = work / "inputs"
|
| 178 |
+
if not a.check_only:
|
| 179 |
+
if (out / "inputs_manifest.json").exists():
|
| 180 |
+
raise SystemExit(f"{out}/inputs_manifest.json exists; inputs are immutable (preserve and inspect)")
|
| 181 |
+
out.mkdir(parents=True, exist_ok=True)
|
| 182 |
+
data = TASK / "data" / a.dataset
|
| 183 |
+
d = PD.load(data)
|
| 184 |
+
folds = pd.read_csv(data / "folds.csv")
|
| 185 |
+
if not np.array_equal(folds["sample_id"].astype(str).to_numpy(), d["sample_ids"]):
|
| 186 |
+
raise SystemExit("folds.csv rows differ from features.npz")
|
| 187 |
+
s = split_rows(a.dataset, a.mode, j, d["sample_ids"], folds, n=a.n,
|
| 188 |
+
support_manifest=a.support_manifest)
|
| 189 |
+
rep, tgt = s["rep"], s["tgt"]
|
| 190 |
+
if a.smoke_rep_ids:
|
| 191 |
+
keep_r = set(a.smoke_rep_ids.split(","))
|
| 192 |
+
rep = np.asarray([r for r in rep if d["sample_ids"][r] in keep_r], dtype=np.int64)
|
| 193 |
+
if a.smoke_reps:
|
| 194 |
+
rep = rep[: a.smoke_reps]
|
| 195 |
+
if a.smoke_targets:
|
| 196 |
+
keep = set(a.smoke_targets.split(","))
|
| 197 |
+
tgt = np.asarray([t for t in tgt if d["sample_ids"][t] in keep], dtype=np.int64)
|
| 198 |
+
s["test"] = [x for x in s["test"] if x in keep]
|
| 199 |
+
if a.mode == "fewshot" and not smoke:
|
| 200 |
+
usable = np.flatnonzero(folds["fold"].to_numpy() >= 0)
|
| 201 |
+
if set(rep.tolist()) | set(tgt.tolist()) != set(usable.tolist()):
|
| 202 |
+
raise SystemExit("representatives + targets do not cover the usable rows")
|
| 203 |
+
# modeled genes
|
| 204 |
+
z = np.load(data / "cells_panel6k.npz", allow_pickle=False)
|
| 205 |
+
panel = z["panel_gene_ids"].astype(str)
|
| 206 |
+
gpos = {g: i for i, g in enumerate(d["gene_ids"])}
|
| 207 |
+
pcanon = np.asarray([gpos[g] for g in panel], dtype=np.int64)
|
| 208 |
+
rows = np.sort(np.concatenate([rep, tgt]))
|
| 209 |
+
bulk_ok = d["bulk_valid"][rows][:, pcanon].all(0)
|
| 210 |
+
sc_ok = d["sc_valid"][rep][:, pcanon].all(0)
|
| 211 |
+
model_pidx = np.flatnonzero(bulk_ok & sc_ok)
|
| 212 |
+
genes = panel[model_pidx]
|
| 213 |
+
if genes.size < 1000:
|
| 214 |
+
raise SystemExit(f"only {genes.size} modeled genes")
|
| 215 |
+
# scorer's scoring genes (all rows of the dataset) for the record
|
| 216 |
+
score_mask = d["bulk_valid"][:, pcanon].all(0) & d["sc_valid"][:, pcanon].all(0)
|
| 217 |
+
# bulk
|
| 218 |
+
import anndata as ad
|
| 219 |
+
B = d["bulk"][rows][:, pcanon[model_pidx]].astype(np.float64)
|
| 220 |
+
if not np.isfinite(B).all() or (B < 0).any():
|
| 221 |
+
raise SystemExit("non-finite or negative bulk on the modeled genes")
|
| 222 |
+
if (B.sum(1) <= 0).any():
|
| 223 |
+
raise SystemExit("a bulk row has no counts on the modeled genes")
|
| 224 |
+
sym = pd.read_csv(TASK.parents[1] / "artifacts/panel_ladder_floor01_1m_20260923/tiers/6k/selected_genes.csv")
|
| 225 |
+
sym = sym.set_index("gene_id").gene_symbol.astype(str)
|
| 226 |
+
var = pd.DataFrame({"gene_symbol": sym.reindex(genes).to_numpy()}, index=pd.Index(genes, name="gene_id"))
|
| 227 |
+
obs_b = pd.DataFrame({"sample_ids": d["sample_ids"][rows], "donor_id": d["donor_ids"][rows],
|
| 228 |
+
"group": d["groups"][rows], "role": np.where(np.isin(rows, rep), "representative", "target")},
|
| 229 |
+
index=pd.Index(d["sample_ids"][rows], name="obs"))
|
| 230 |
+
if not a.check_only:
|
| 231 |
+
ad.AnnData(X=B, obs=obs_b, var=var).write_h5ad(out / "bulk.h5ad")
|
| 232 |
+
# representative cells
|
| 233 |
+
X = sp.csr_matrix((z["data"], z["indices"], z["indptr"]), shape=tuple(int(x) for x in z["shape"]))
|
| 234 |
+
rs = np.asarray(z["row_sample"], dtype=np.int64)
|
| 235 |
+
blocks, obs_rows, per_rep = [], [], []
|
| 236 |
+
rng = np.random.default_rng(SEED)
|
| 237 |
+
for r in rep:
|
| 238 |
+
cells = np.flatnonzero(rs == r)
|
| 239 |
+
if a.smoke_cells and cells.size > a.smoke_cells:
|
| 240 |
+
cells = np.sort(rng.choice(cells, a.smoke_cells, replace=False))
|
| 241 |
+
Xr = X[cells][:, model_pidx].tocsr().astype(np.float32)
|
| 242 |
+
lib = np.asarray(Xr.sum(1)).ravel()
|
| 243 |
+
if (lib <= 0).any():
|
| 244 |
+
raise SystemExit(f"{d['sample_ids'][r]}: {int((lib <= 0).sum())} cells without counts on the modeled genes")
|
| 245 |
+
blocks.append(Xr)
|
| 246 |
+
obs_rows.append(pd.DataFrame({"sample_ids": d["sample_ids"][r], "donor_id": d["donor_ids"][r],
|
| 247 |
+
"source_cell_row": cells}))
|
| 248 |
+
per_rep.append({"sample_id": str(d["sample_ids"][r]), "donor_id": str(d["donor_ids"][r]),
|
| 249 |
+
"group": str(d["groups"][r]), "n_cells": int(cells.size),
|
| 250 |
+
"median_umi_modeled_genes": float(np.median(lib))})
|
| 251 |
+
Xs = sp.vstack(blocks, format="csr")
|
| 252 |
+
obs_s = pd.concat(obs_rows, ignore_index=True)
|
| 253 |
+
obs_s.index = pd.Index([f"{a_}|{b_}" for a_, b_ in zip(obs_s.sample_ids, obs_s.source_cell_row)], name="cell")
|
| 254 |
+
if not a.check_only:
|
| 255 |
+
ad.AnnData(X=Xs, obs=obs_s, var=var.copy()).write_h5ad(out / "rep_sc.h5ad")
|
| 256 |
+
lib_all = np.asarray(Xs.sum(1)).ravel()
|
| 257 |
+
depth = float(np.median(lib_all))
|
| 258 |
+
cond = s["condition"]
|
| 259 |
+
man = {
|
| 260 |
+
"schema": "scsemi_paired.inputs.v1", "written_utc": datetime.now(timezone.utc).isoformat(),
|
| 261 |
+
"dataset": a.dataset, "mode": a.mode, "split": j, "smoke": smoke,
|
| 262 |
+
"smoke_settings": {"reps": a.smoke_reps, "cells": a.smoke_cells, "targets": a.smoke_targets,
|
| 263 |
+
"rep_ids": a.smoke_rep_ids} if smoke else None,
|
| 264 |
+
"train_donors": s["train_donors"],
|
| 265 |
+
"representatives": per_rep, "targets": [str(x) for x in d["sample_ids"][tgt]],
|
| 266 |
+
"target_order_test_samples": s["test"],
|
| 267 |
+
"bulk_row_order": [str(x) for x in d["sample_ids"][rows]],
|
| 268 |
+
"n_representatives": int(rep.size), "n_targets": int(tgt.size), "n_rep_cells": int(Xs.shape[0]),
|
| 269 |
+
"modeled_genes": {"n": int(genes.size), "gene_ids": genes.tolist(), "panel_index": model_pidx.tolist(),
|
| 270 |
+
"rule": "6k panel genes with bulk_valid in every rep+target row and sc_valid in every rep row",
|
| 271 |
+
"equals_scorer_scoring_genes": bool(np.array_equal(model_pidx, np.flatnonzero(score_mask))),
|
| 272 |
+
"n_scorer_scoring_genes": int(score_mask.sum())},
|
| 273 |
+
"depth": {"value": depth, "rule": "median over all representative cells (all rows of the training donors) of the "
|
| 274 |
+
"per-cell UMI sum on the modeled genes; every generated cell is scaled to this expected library",
|
| 275 |
+
"n_cells": int(lib_all.size)},
|
| 276 |
+
"condition_npz": str(cond), "condition_sha256": sha(cond),
|
| 277 |
+
"sources": {"features.npz": sha(data / "features.npz"), "folds.csv": sha(data / "folds.csv"),
|
| 278 |
+
"cells_panel6k.npz": sha(data / "cells_panel6k.npz"),
|
| 279 |
+
**{k: sha(v) for k, v in s["sources"].items()}},
|
| 280 |
+
"files": ({"bulk.h5ad": sha(out / "bulk.h5ad"), "rep_sc.h5ad": sha(out / "rep_sc.h5ad")}
|
| 281 |
+
if not a.check_only else None),
|
| 282 |
+
"builder_sha256": sha(Path(__file__)),
|
| 283 |
+
}
|
| 284 |
+
if a.mode == "strict":
|
| 285 |
+
man["support_sha256"] = s["support_sha256"]
|
| 286 |
+
man["target_donors"] = s["target_donors"]
|
| 287 |
+
if a.mode == "budget":
|
| 288 |
+
man["target_donors"] = sorted({str(x) for x in d["donor_ids"][tgt]})
|
| 289 |
+
man["budget"] = s["budget"]
|
| 290 |
+
with np.load(cond, allow_pickle=False) as cz:
|
| 291 |
+
cond_ids = cz["sample_ids"].astype(str).tolist()
|
| 292 |
+
if not smoke and sorted(cond_ids) != sorted(man["targets"]):
|
| 293 |
+
raise SystemExit("condition NPZ sample_ids differ from the targets")
|
| 294 |
+
man["condition_sample_order"] = cond_ids
|
| 295 |
+
if a.check_only:
|
| 296 |
+
summary = {"dataset": a.dataset, "mode": a.mode, "split": j, "n": a.n, "work": str(work),
|
| 297 |
+
"reps": [r["sample_id"] for r in per_rep], "targets": man["targets"],
|
| 298 |
+
"rep_cells": {r["sample_id"]: r["n_cells"] for r in per_rep}, "n_rep_cells": int(Xs.shape[0]),
|
| 299 |
+
"modeled_genes": int(genes.size), "modeled_panel_index": model_pidx.tolist(),
|
| 300 |
+
"equals_scorer_genes": man["modeled_genes"]["equals_scorer_scoring_genes"],
|
| 301 |
+
"depth": depth, "condition_npz": str(cond), "condition_matches_targets": True,
|
| 302 |
+
"train_donors": s["train_donors"], **({"budget": s["budget"]} if a.mode == "budget" else {})}
|
| 303 |
+
if a.check_out is not None:
|
| 304 |
+
a.check_out.parent.mkdir(parents=True, exist_ok=True)
|
| 305 |
+
a.check_out.write_text(json.dumps(summary, indent=1) + "\n")
|
| 306 |
+
print(json.dumps({k: summary[k] for k in ("dataset", "mode", "split", "n", "n_rep_cells", "modeled_genes",
|
| 307 |
+
"equals_scorer_genes", "depth")} | {"reps": len(summary["reps"]),
|
| 308 |
+
"targets": len(summary["targets"])}))
|
| 309 |
+
return 0
|
| 310 |
+
tmp = out / "inputs_manifest.json.tmp"
|
| 311 |
+
tmp.write_text(json.dumps(man, indent=1) + "\n")
|
| 312 |
+
tmp.replace(out / "inputs_manifest.json")
|
| 313 |
+
print(json.dumps({"dataset": a.dataset, "mode": a.mode, "split": j, "reps": int(rep.size), "targets": int(tgt.size),
|
| 314 |
+
"rep_cells": int(Xs.shape[0]), "modeled_genes": int(genes.size),
|
| 315 |
+
"equals_scorer_genes": man["modeled_genes"]["equals_scorer_scoring_genes"], "depth": depth}))
|
| 316 |
+
return 0
|
| 317 |
+
|
| 318 |
+
|
| 319 |
+
if __name__ == "__main__":
|
| 320 |
+
sys.exit(main())
|
paper-releases/pbisc-diffusion/updates/20261012T143729Z-strictpairs-recovery-two-host/diffusion/dataset/server_1/model8/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/archive_queue/ARCHIVE_RECOVERY_QUEUE.json
ADDED
|
@@ -0,0 +1,14 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
+
{
|
| 2 |
+
"first_existing_update": "20261012T130738Z-strictpairs-implementation",
|
| 3 |
+
"first_service": "pbisc-strict-archive-instrumented-resume-20261012.service",
|
| 4 |
+
"updates": [
|
| 5 |
+
{
|
| 6 |
+
"id": "20261012T131501Z-strictpairs-final-caption",
|
| 7 |
+
"request": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/archive/20261012T131501Z-strictpairs-final-caption/request.json"
|
| 8 |
+
},
|
| 9 |
+
{
|
| 10 |
+
"id": "20261012T143729Z-strictpairs-recovery-two-host",
|
| 11 |
+
"request": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/request.json"
|
| 12 |
+
}
|
| 13 |
+
]
|
| 14 |
+
}
|
paper-releases/pbisc-diffusion/updates/20261012T143729Z-strictpairs-recovery-two-host/diffusion/dataset/server_1/model8/plans/paper_figures_strictpairs_20261012/archive/20261012T143729Z-strictpairs-recovery-two-host/snapshot/archive_queue/finish_recovery_archives.py
ADDED
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|
| 1 |
+
"""Finish the explicitly approved archive queue once; no publish retry loop."""
|
| 2 |
+
import json
|
| 3 |
+
from pathlib import Path
|
| 4 |
+
import subprocess
|
| 5 |
+
import sys
|
| 6 |
+
import time
|
| 7 |
+
|
| 8 |
+
ROOT = Path(__file__).resolve().parents[1]
|
| 9 |
+
sys.path.insert(0, str(ROOT / "tools"))
|
| 10 |
+
from runtime import atomic_json, sha256, stamp
|
| 11 |
+
|
| 12 |
+
RELEASE = Path('/home/sj_server_1/PBISC/paper-release-20260928')
|
| 13 |
+
PYTHON = '/home/sj_server_1/miniforge3/bin/python'
|
| 14 |
+
CLI = RELEASE / 'maintenance/update.py'
|
| 15 |
+
STATE = ROOT / 'recoveries/ARCHIVE_RECOVERY_STATUS.json'
|
| 16 |
+
|
| 17 |
+
|
| 18 |
+
def verified(identifier):
|
| 19 |
+
folder = RELEASE / 'maintenance/updates' / identifier
|
| 20 |
+
receipt = folder / 'UPDATE_VERIFIED.json'
|
| 21 |
+
status = folder / 'STATUS.json'
|
| 22 |
+
return receipt.is_file() and status.is_file() and json.loads(status.read_text()).get('phase') == 'verified'
|
| 23 |
+
|
| 24 |
+
|
| 25 |
+
def main():
|
| 26 |
+
queue = json.loads((ROOT / 'recoveries/ARCHIVE_RECOVERY_QUEUE.json').read_text())
|
| 27 |
+
state = {'state': 'waiting_existing_publisher', 'started_at': stamp(), 'completed': []}
|
| 28 |
+
atomic_json(STATE, state)
|
| 29 |
+
try:
|
| 30 |
+
while not verified(queue['first_existing_update']):
|
| 31 |
+
active = subprocess.run(['systemctl', '--user', 'is-active', '--quiet', queue['first_service']])
|
| 32 |
+
if active.returncode:
|
| 33 |
+
raise RuntimeError('existing archive resume stopped without verification; inspect diagnostics')
|
| 34 |
+
time.sleep(15)
|
| 35 |
+
for update in queue['updates']:
|
| 36 |
+
state.update(state='publishing', active=update['id'], updated_at=stamp())
|
| 37 |
+
atomic_json(STATE, state)
|
| 38 |
+
if not verified(update['id']):
|
| 39 |
+
folder = RELEASE / 'maintenance/updates' / update['id']
|
| 40 |
+
if not (folder / 'manifest.json').is_file():
|
| 41 |
+
subprocess.run([PYTHON, str(CLI), 'prepare', '--request', update['request'], '--id', update['id']], check=True)
|
| 42 |
+
subprocess.run([PYTHON, str(CLI), 'publish', update['id'], '--execute'], check=True)
|
| 43 |
+
if not verified(update['id']):
|
| 44 |
+
raise RuntimeError('publisher returned without a verified receipt')
|
| 45 |
+
state['completed'].append(update['id'])
|
| 46 |
+
latest = json.loads((RELEASE / 'LATEST.json').read_text())
|
| 47 |
+
last = queue['updates'][-1]['id']
|
| 48 |
+
receipt = RELEASE / 'maintenance/updates' / last / 'UPDATE_VERIFIED.json'
|
| 49 |
+
if latest['id'] != last or latest['verified_receipt_sha256'] != sha256(receipt):
|
| 50 |
+
raise RuntimeError('archive latest pointer does not match recovery receipt')
|
| 51 |
+
state.update(state='completed', active=None, updated_at=stamp(), latest_id=last)
|
| 52 |
+
atomic_json(STATE, state)
|
| 53 |
+
except BaseException as exc:
|
| 54 |
+
state.update(state='failed_needs_inspection', error=str(exc), updated_at=stamp())
|
| 55 |
+
atomic_json(STATE, state)
|
| 56 |
+
raise
|
| 57 |
+
|
| 58 |
+
|
| 59 |
+
if __name__ == '__main__':
|
| 60 |
+
main()
|