junidude14 commited on
Commit
aba5595
·
verified ·
1 Parent(s): 09ed873

Archive 4 checkpoints (1-4)

Browse files
paper-releases/pbisc-diffusion/updates/20261002T085943Z-deck-restructure-contrast-metrics-zeroshot-len/diffusion/dataset/server_1/model8/presentations/2026-09-30--paper-summary--r00/tools/fold_sizes.py ADDED
@@ -0,0 +1,34 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Shared wording for the 5-fold "every training donor" arm (2026-10-02).
2
+
3
+ The deck used to call this arm "all" / "all training pairs", which reads as if test pairs were used. They never are:
4
+ each fold's LoRA trains on the other four folds minus 7-8 inner-validation donors, and its RUN.json lists the test rows
5
+ as "test_rows_never_loaded_for_training". Every figure now shows the actual number of training pairs instead.
6
+ """
7
+ import json
8
+ from functools import lru_cache
9
+ from pathlib import Path
10
+
11
+ PLAN = Path("/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/"
12
+ "paired_finetune_intradataset_20260927")
13
+ FOLD_ARM_LABEL = "5-fold CV (other 4 folds)" # arm suffix, e.g. "LoRA, 5-fold CV (other 4 folds)"
14
+ FOLD_TITLE = "5-fold CV: train on the other 4 folds"
15
+ FOLD_NOTE = "each fold model trains on the other 4 folds (minus inner-val); its test fold is never trained on"
16
+
17
+
18
+ @lru_cache(maxsize=None)
19
+ def train_pairs(ds: str, run: str = "real_lora") -> tuple[int, int]:
20
+ """(min, max) training pairs per fold of the 5-fold LoRA run, from runs/<ds>/fold<k>/<run>/RUN.json."""
21
+ n = []
22
+ for k in range(5):
23
+ r = json.loads((PLAN / "runs" / ds / f"fold{k}" / run / "RUN.json").read_text())
24
+ tr, te = r["train_rows"], r["test_rows_never_loaded_for_training"]
25
+ if set(tr) & set(te):
26
+ raise SystemExit(f"{ds} fold {k}: train and test rows overlap")
27
+ n.append(len(tr))
28
+ return min(n), max(n)
29
+
30
+
31
+ def all_label(ds: str) -> str:
32
+ """Tick label for the 'every training donor' point: '78–79' (ImMicro), '58–59' (sepsis)."""
33
+ lo, hi = train_pairs(ds)
34
+ return f"{lo}" if lo == hi else f"{lo}–{hi}"
paper-releases/pbisc-diffusion/updates/20261002T085943Z-deck-restructure-contrast-metrics-zeroshot-len/diffusion/dataset/server_1/model8/presentations/2026-09-30--paper-summary--r00/tools/restructure_20261002.py ADDED
@@ -0,0 +1,143 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ #!/usr/bin/env python3
2
+ """One-off restructure of data/slides_spec.json (2026-10-02, user request): no Backup section.
3
+
4
+ The backup slides move into the sections they support, a metric-overview slide opens section 4, and every slide that
5
+ uses a published method, metric or baseline gets a one-line reference footer (short citations; full citations with
6
+ DOI in the speaker notes). Slide content (titles, keywords, footnotes) is left to the section scripts and
7
+ tools/sync_sec09_text.py; this script only orders slides, sets section labels, the agenda and the references.
8
+ Run once on the pre-restructure spec (it refuses to run twice). The pre-restructure spec is in
9
+ _archive/2026-10-02_before_restructure/.
10
+ """
11
+ import json
12
+ import sys
13
+ from pathlib import Path
14
+
15
+ DECK = Path(__file__).resolve().parents[1]
16
+ SPEC = DECK / "data" / "slides_spec.json"
17
+
18
+ # short citation for the footer, full citation for the notes (verified 2026-10-02; PDFs in reference-papers/)
19
+ REF = {
20
+ "SDD": ("Ostheimer 2025, arXiv", "Ostheimer et al. Sparse Data Diffusion for scientific simulations in biology and physics. arXiv:2502.02448 (2025)"),
21
+ "DDIM": ("Song 2021, ICLR", "Song, Meng & Ermon. Denoising Diffusion Implicit Models. ICLR 2021"),
22
+ "scDiffusion": ("Luo 2024, Bioinformatics", "Luo et al. scDiffusion: conditional generation of high-quality single-cell data using diffusion model. Bioinformatics 40(9):btae518 (2024)"),
23
+ "scSemi": ("Wang 2024, Nat Commun", "Wang et al. scSemiProfiler: advancing large-scale single-cell studies through semi-profiling with deep generative models and active learning. Nat Commun 15:5989 (2024). doi:10.1038/s41467-024-50150-1"),
24
+ "scANVI": ("Xu 2021, Mol Syst Biol", "Xu et al. Probabilistic harmonization and annotation of single-cell transcriptomics data with deep generative models. Mol Syst Biol 17:e9620 (2021)"),
25
+ "LoRA": ("Hu 2022, ICLR", "Hu et al. LoRA: Low-Rank Adaptation of Large Language Models. ICLR 2022"),
26
+ "Kyn": ("Kynkäänniemi 2019, NeurIPS", "Kynkäänniemi et al. Improved precision and recall metric for assessing generative models. NeurIPS 2019"),
27
+ "Naeem": ("Naeem 2020, ICML", "Naeem et al. Reliable fidelity and diversity metrics for generative models. ICML 2020"),
28
+ "Khayat": ("Khayatkhoei 2023, ICML", "Khayatkhoei & AbdAlmageed. Emergent asymmetry of precision and recall for measuring fidelity and diversity of generative models in high dimensions. ICML 2023"),
29
+ "LopezPaz": ("Lopez-Paz 2017, ICLR", "Lopez-Paz & Oquab. Revisiting classifier two-sample tests. ICLR 2017"),
30
+ "Gretton": ("Gretton 2012, JMLR", "Gretton et al. A kernel two-sample test. JMLR 13:723-773 (2012)"),
31
+ "GEARS": ("Roohani 2024, Nat Biotechnol", "Roohani, Huang & Leskovec. Predicting transcriptional outcomes of novel multigene perturbations with GEARS. Nat Biotechnol 42:927-935 (2024). doi:10.1038/s41587-023-01905-6"),
32
+ "Systema": ("Viñas Torné 2026, Nat Biotechnol", "Viñas Torné et al. Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation. Nat Biotechnol 44:1050-1059 (2026). doi:10.1038/s41587-025-02777-8"),
33
+ "AhlmannEltze": ("Ahlmann-Eltze 2025, Nat Methods", "Ahlmann-Eltze, Huber & Anders. Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines. Nat Methods 22:1657-1661 (2025). doi:10.1038/s41592-025-02772-6"),
34
+ "Li2026": ("Li 2026, Sci Adv", "Li et al. A systematic comparison of single-cell perturbation response prediction models. Sci Adv 12:eaed3414 (2026). doi:10.1126/sciadv.aed3414"),
35
+ "Squair": ("Squair 2021, Nat Commun", "Squair et al. Confronting false discoveries in single-cell differential expression. Nat Commun 12:5692 (2021). doi:10.1038/s41467-021-25960-2"),
36
+ "voom": ("Law 2014, Genome Biol", "Law, Chen, Shi & Smyth. voom: precision weights unlock linear model analysis tools for RNA-seq read counts. Genome Biol 15:R29 (2014)"),
37
+ "Irizarry": ("Irizarry 2005, Nat Methods", "Irizarry et al. Multiple-laboratory comparison of microarray platforms. Nat Methods 2:345-350 (2005). doi:10.1038/nmeth756"),
38
+ "BayesPrism": ("Chu 2022, Nat Cancer", "Chu et al. Cell type and gene expression deconvolution with BayesPrism enables Bayesian integrative analysis across bulk and single-cell RNA sequencing in oncology. Nat Cancer 3:505-517 (2022)"),
39
+ }
40
+ METRIC_REFS = ["Kyn", "Naeem", "LopezPaz", "Gretton", "scSemi", "GEARS", "Systema", "Li2026", "Squair", "voom", "Irizarry"]
41
+
42
+ AGENDA = [
43
+ "Model overview: diffusion from bulk to cells",
44
+ "Backbone: SDD, scDiffusion, bulk conditioning",
45
+ "Architecture ablation: width, context, gene panel",
46
+ "How we score cells; SLE benchmark vs scSemiProfiler",
47
+ "Real bulk ≠ pseudobulk: why zero-shot fails",
48
+ "Fine-tuning on paired bulk–sc data; evaluation design",
49
+ "LoRA: compute, rank and K ablations",
50
+ "How many bulk–sc pairs are needed",
51
+ "Paired-cohort validation vs scSemiProfiler",
52
+ "Next: cohorts with a paired subset (planned)",
53
+ ]
54
+ SECTION = {"1": "1 Model overview", "2": "2 Backbone", "3": "3 Architecture ablation", "4": "4 Metrics + SLE benchmark",
55
+ "5": "5 Real bulk vs pseudobulk", "6": "6 Paired fine-tuning", "7": "7 LoRA ablations", "8": "8 Pairs needed",
56
+ "9": "9 Paired validation", "10": "10 Paired-subset cohorts"}
57
+ METRICS_SLIDE = {
58
+ "kind": "content", "section": "4", "title": "How we score generated cells", "layout": "full",
59
+ "figures": ["figures/sec04_metrics_overview.png"],
60
+ "keywords": ["Cells, composition and disease signal, separately",
61
+ "Every metric next to its control or ceiling",
62
+ "Same donors and reference cells for every method"],
63
+ "footnote": "Definitions follow the cited papers; scorers: tools/score_ft.py, extra_metrics.py, contrast_extra.py.",
64
+ "sources": "tools/sec04_metrics_overview.py; data/sec04_metrics_overview.csv",
65
+ "refs_full": [REF[k][1] for k in METRIC_REFS],
66
+ }
67
+ # new order: (title, section, refs); the metric slide is inserted by key "METRICS"
68
+ ORDER = [
69
+ ("PBISC-Diffusion: bulk-to-single-cell generation", None, []),
70
+ ("Outline", None, []),
71
+ ("PBISC-Diffusion: bulk in, cells out", "1", ["SDD", "DDIM"]),
72
+ ("Denoiser: joint value + support diffusion", "1", ["SDD"]),
73
+ ("Backbone: SDD → PBISC-Diffusion", "2", ["SDD", "scDiffusion"]),
74
+ ("Bulk conditioning", "2", []),
75
+ ("Width & context ablation: loss saturation", "3", []),
76
+ ("Width & context ablation: benchmark", "3", []),
77
+ ("Gene context: 2k / 3k / 6k / 15k", "3", []),
78
+ ("METRICS", "4", []),
79
+ ("SLE benchmark: PBISC vs scSemiProfiler", "4", ["scSemi", "scANVI"]),
80
+ ("SLE benchmark: per cell type", "4", ["scSemi"]),
81
+ ("Bulk broadcast baseline", "4", ["Systema", "AhlmannEltze", "BayesPrism"]),
82
+ ("Real bulk ≠ pseudobulk (model input)", "5", []),
83
+ ("Same shift in three paired cohorts", "5", []),
84
+ ("Consequence: cells off-manifold", "5", ["Kyn", "Naeem"]),
85
+ ("Consequence: disease direction flips", "5", []),
86
+ ("Fine-tuning with paired bulk + sc", "6", ["LoRA"]),
87
+ ("Evaluation design", "6", []),
88
+ ("Full vs LoRA vs cond.-encoder-only", "7", ["LoRA"]),
89
+ ("LoRA rank: r = 4, 16, 64", "7", ["LoRA"]),
90
+ ("K diversification: no gain", "7", []),
91
+ ("Pairs needed: composition, coverage, training steps", "8", ["Kyn", "Naeem"]),
92
+ ("Pairs needed: donor and disease signal", "8", ["GEARS", "Li2026"]),
93
+ ("Five paired cohorts", "9", []),
94
+ ("5 donors: LoRA vs scSemiProfiler — cells", "9", ["Kyn", "Naeem", "scSemi"]),
95
+ ("5 donors: realism beyond precision/coverage", "9", ["LopezPaz", "Gretton", "scSemi"]),
96
+ ("5 donors: precision/coverage at k = 3, 5, 10", "9", ["Naeem", "Khayat"]),
97
+ ("scSemiProfiler copies its representative", "9", ["scSemi"]),
98
+ ("5 donors: LoRA vs scSemiProfiler — disease signal", "9", ["GEARS", "Systema", "Li2026", "voom", "Irizarry"]),
99
+ ("5 donors: time to apply", "9", ["scSemi"]),
100
+ ("5-fold CV: train on the other 4 folds", "9", ["Systema", "Li2026"]),
101
+ ("5-fold: realism beyond precision/coverage", "9", ["LopezPaz", "Gretton"]),
102
+ ("Next: cohorts with a paired subset (planned)", "10", []),
103
+ ]
104
+ OLD_TITLE = {"5-fold CV: train on the other 4 folds": "All pairs, 5-fold"}
105
+
106
+
107
+ def main() -> int:
108
+ spec = json.loads(SPEC.read_text())
109
+ sl = spec["slides"]
110
+ if any(s.get("title") == METRICS_SLIDE["title"] for s in sl):
111
+ sys.exit("already restructured")
112
+ by = {s["title"]: s for s in sl}
113
+ out, used = [], set()
114
+ for title, sec, refs in ORDER:
115
+ if title == "METRICS":
116
+ s = dict(METRICS_SLIDE)
117
+ else:
118
+ key = title if title in by else OLD_TITLE.get(title, title)
119
+ if key not in by:
120
+ sys.exit(f"slide not found: {title!r}")
121
+ s = by[key]
122
+ used.add(key)
123
+ if sec:
124
+ s["section"] = sec
125
+ s["section_label"] = SECTION[sec]
126
+ s.pop("backup", None)
127
+ if refs:
128
+ s["refs"] = [REF[k][0] for k in refs]
129
+ s["refs_full"] = [REF[k][1] for k in refs]
130
+ if s.get("kind") == "agenda":
131
+ s["items"] = AGENDA
132
+ out.append(s)
133
+ left = [t for t in by if t not in used and by[t].get("kind") != "divider"]
134
+ if left:
135
+ sys.exit(f"slides not placed: {left}")
136
+ spec["slides"] = out
137
+ SPEC.write_text(json.dumps(spec, indent=2, ensure_ascii=False) + "\n")
138
+ print(f"{len(out)} slides (was {len(sl)})")
139
+ return 0
140
+
141
+
142
+ if __name__ == "__main__":
143
+ sys.exit(main())
paper-releases/pbisc-diffusion/updates/20261002T085943Z-deck-restructure-contrast-metrics-zeroshot-len/diffusion/dataset/server_1/model8/presentations/2026-09-30--paper-summary--r00/tools/scsemi_results.py ADDED
@@ -0,0 +1,112 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Where the scSemiProfiler 5-fold (CV) and equal-budget results will appear, and a tolerant lookup for them.
2
+
3
+ Shared helper of the 2026-09-30 paper-summary deck (not run directly). CPU only; reads files, never writes.
4
+
5
+ Planned locations (2026-10-02; the GPU runs are prepared by another agent and may not exist yet):
6
+ CV arm scsemi__raw <PLAN>/scores/<ds>/scsemi_cv_20261002/{fold<k>,pooled}/
7
+ equal budget arms scsemi_n{5,10,20,40}__raw <PLAN>/scores/<ds>/scsemi_budget_20261002/{fold<k>,pooled}/
8
+ (ImMicro and sepsis only)
9
+ extra metrics (classifier AUC, MMD^2, E_N, P/C at k = 3/5/10)
10
+ <PLAN>/scores_extra/<ds>/scsemi_cv_20261002/ and .../scsemi_budget_20261002/ (any depth below)
11
+ Giroux disease metrics without sex-linked genes, if rescored:
12
+ <PLAN>/scores_nosex/giroux2022/scsemi_cv_20261002/...
13
+
14
+ The deck uses cross-fitted pooled calls only: directories below <exp>/ with a path part starting with "pooled"
15
+ (pooled, pooled_deg, ...), never fold<k>/ or arms/. A call is accepted only if it scores the same donors with the
16
+ same reference cells as the main pooled call and its generation receipt is not marked unverified (accept()).
17
+
18
+ Every script that uses this module prints a note and draws nothing for scSemiProfiler when no accepted call exists.
19
+ DECK_SCSEMI_PLAN_ROOT overrides <PLAN> for these lookups only (the synthetic presence test in a scratch copy).
20
+ """
21
+ from __future__ import annotations
22
+
23
+ import json
24
+ import os
25
+ import re
26
+ from pathlib import Path
27
+
28
+ PLAN_DEFAULT = Path("/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/"
29
+ "paired_finetune_intradataset_20260927")
30
+ CV_EXP = "scsemi_cv_20261002"
31
+ BUDGET_EXP = "scsemi_budget_20261002"
32
+ CV_ARM = "scsemi__raw"
33
+ BUDGET_RE = re.compile(r"^scsemi_n(\d+)__raw$")
34
+ FOLD_RE = re.compile(r"^fold\d+$")
35
+ LABEL_CV = "scSemiProfiler, 5-fold CV (other 4 folds)"
36
+
37
+
38
+ def plan_root() -> Path:
39
+ return Path(os.environ.get("DECK_SCSEMI_PLAN_ROOT", str(PLAN_DEFAULT)))
40
+
41
+
42
+ def is_test_root() -> bool:
43
+ return plan_root() != PLAN_DEFAULT
44
+
45
+
46
+ def _pooled_dir(rel: Path) -> bool:
47
+ parts = rel.parts
48
+ return (not any(FOLD_RE.match(p) or p == "arms" for p in parts)) and any(p.startswith("pooled") for p in parts)
49
+
50
+
51
+ def pooled_dirs(ds: str, exp: str, tree: str = "scores") -> list[Path]:
52
+ """Directories with a summary.json of the pooled calls of one experiment, 'pooled' before 'pooled_deg' etc."""
53
+ root = plan_root() / tree / ds / exp
54
+ if not root.is_dir():
55
+ return []
56
+ out = [sp.parent for sp in root.rglob("summary.json") if _pooled_dir(sp.parent.relative_to(root))]
57
+ return sorted(out, key=lambda p: (len(p.relative_to(root).parts), p.name != "pooled", str(p)))
58
+
59
+
60
+ def _arms(d: Path) -> list[str]:
61
+ try:
62
+ return list(json.loads((d / "summary.json").read_text()).get("arms") or [])
63
+ except (OSError, ValueError):
64
+ return []
65
+
66
+
67
+ def cv_calls(ds: str, tree: str = "scores") -> list[Path]:
68
+ """Pooled call directories that contain the CV arm."""
69
+ return [d for d in pooled_dirs(ds, CV_EXP, tree) if CV_ARM in _arms(d)]
70
+
71
+
72
+ def budget_calls(ds: str, tree: str = "scores") -> dict[int, list[tuple[str, Path]]]:
73
+ """n -> [(arm, pooled call dir)] for the equal-budget arms scsemi_n<n>__raw."""
74
+ out: dict[int, list[tuple[str, Path]]] = {}
75
+ for d in pooled_dirs(ds, BUDGET_EXP, tree):
76
+ for a in _arms(d):
77
+ m = BUDGET_RE.match(a)
78
+ if m:
79
+ out.setdefault(int(m.group(1)), []).append((a, d))
80
+ return out
81
+
82
+
83
+ def accept(summary: dict, ref_summary: dict, arm: str) -> list[str]:
84
+ """Reasons to reject one scSemiProfiler arm of a call against the main pooled call ([] = accepted)."""
85
+ why = []
86
+ if arm not in (summary.get("arms") or []):
87
+ why.append(f"arm {arm} not in the call")
88
+ if set(map(str, summary.get("donors", []))) != set(map(str, ref_summary.get("donors", []))):
89
+ why.append(f"donor set differs ({len(summary.get('donors', []))} vs {len(ref_summary.get('donors', []))})")
90
+ rs = summary.get("reference", {}).get("reference_sha256")
91
+ if rs != ref_summary.get("reference", {}).get("reference_sha256"):
92
+ why.append("reference cells differ (reference_sha256)")
93
+ if summary.get("per_arm", {}).get(arm, {}).get("receipt_verified", True) is False:
94
+ why.append("generation receipt not verified")
95
+ return why
96
+
97
+
98
+ def extra_units(ds: str, exp: str) -> list[Path]:
99
+ """Extra-metric unit directories (metrics.csv + en.csv) below scores_extra/<ds>/<exp>/, pooled ones first;
100
+ fold<k>/ units are skipped (the deck shows the pooled design)."""
101
+ root = plan_root() / "scores_extra" / ds / exp
102
+ if not root.is_dir():
103
+ return []
104
+ out = []
105
+ for mp in root.rglob("metrics.csv"):
106
+ d = mp.parent
107
+ rel = d.relative_to(root)
108
+ if any(FOLD_RE.match(p) for p in rel.parts) or not (d / "en.csv").is_file():
109
+ continue
110
+ out.append(d)
111
+ return sorted(out, key=lambda p: (not any(x.startswith("pooled") for x in p.relative_to(root).parts),
112
+ len(p.relative_to(root).parts), str(p)))
paper-releases/pbisc-diffusion/updates/20261002T085943Z-deck-restructure-contrast-metrics-zeroshot-len/diffusion/dataset/server_1/model8/presentations/2026-09-30--paper-summary--r00/tools/sec01_overview.py ADDED
@@ -0,0 +1,633 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Section 1 (model overview) figures for the 2026-09-30 paper-summary deck.
2
+
3
+ Outputs (deck folder only):
4
+ figures/sec01_fig1a_denoiser.{svg,png,pdf} deck redraw of manuscript Fig. 1a with slide-size labels
5
+ (temporary) sec01_fig1b_inference.{svg,png,pdf} deck redraw of manuscript Fig. 1b, placed into sec01_slide_a
6
+ (not saved) sec01_corpus pretraining corpus panel, drawn inside sec01_slide_a
7
+ figures/sec01_slide_a.{png,pdf} slide (a) composite, exactly 12.3 in wide
8
+ data/sec01_corpus_datasets.csv, data/sec01_recipe_k.csv, data/sec01_model_numbers.csv,
9
+ data/sec01_fig1_label_pt.csv (on-slide point size of every text line in the two redraws)
10
+
11
+ The manuscript SVG is only read. The deck copies change label sizes, drop the panel letters and the
12
+ legend row, widen a few boxes so the larger labels fit, and (panel b) say that cells differ by x_T and by
13
+ the Bernoulli support draw (drawn read-out, manuscript Methods). CPU only; every number is read from the
14
+ source files named below.
15
+ """
16
+ import html
17
+ import json
18
+ import re
19
+ import sys
20
+ from collections import defaultdict
21
+ from pathlib import Path
22
+
23
+ DECK = Path("/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/presentations/2026-09-30--paper-summary--r00")
24
+ sys.path.insert(0, str(DECK / "tools"))
25
+ import style # noqa: E402
26
+
27
+ import cairosvg # 2.9.1, the renderer recorded in fig01_architecture.provenance.json # noqa: E402
28
+ import fitz # PyMuPDF, only to check page sizes # noqa: E402
29
+ import matplotlib.pyplot as plt # noqa: E402
30
+ import numpy as np # noqa: E402
31
+ import pandas as pd # noqa: E402
32
+ from PIL import ImageFont # noqa: E402
33
+
34
+ FIG = DECK / "figures"
35
+ DATA = DECK / "data"
36
+
37
+ MS = Path("/home/sj_server_1/PBISC/paper-release-20260928/manuscript")
38
+ FIG1_SVG = MS / "figures/fig01_architecture.svg"
39
+ METHODS = MS / "sections/methods.tex"
40
+ SRC_MANIFEST = Path("/home/sj_server_1/PBISC/immun-pbmc-fm/model_7_no_annotation_sh_hwang/data/e2_full_source/dataset_manifest.json")
41
+ IDX_MANIFEST = Path("/home/sj_server_1/PBISC/immun-pbmc-fm/model_7_no_annotation_sh_hwang/data/e2_full_index/dataset_manifest.json")
42
+ M8 = Path("/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion")
43
+ RUN = M8 / "runs/f01_6k_1x_seed20260627"
44
+ CFG = RUN / "effective_config.json"
45
+ STATUS = RUN / "RUN_STATUS.json"
46
+ CONTRACT = RUN / "ALLCELL_DATA_CONTRACT.json"
47
+ PLAN = M8 / "plans/full_recipe_allcells_6k_broad_20260909"
48
+ TOPUP_CSV = PLAN / "topup_v1/topup_recipes.csv"
49
+ SHARD_OFFSETS = PLAN / "topup_v1/shard_offsets.csv"
50
+ COVERAGE = PLAN / "coverage_v1/summary.json"
51
+ MODEL_PY = M8 / "src/pbisc_sdd/model.py"
52
+
53
+ # Short readable labels for the 22 corpus datasets (text only; counts come from the manifest).
54
+ LABELS = {
55
+ "001": "Perez SLE", "005": "OneK1K", "006": "AIDA", "007": "Miao RA", "009": "AIFI Health Atlas",
56
+ "010": "ScaleBio PBMC", "053": "Hao CITE-seq", "058": "COVID immunodeficiency",
57
+ "061": "RA at-risk (Savage)", "065": "Sound Life", "071": "JDM CITE-seq", "074": "COMBAT",
58
+ "081": "COVID atlas (Seq-Well)", "093": "SARS-CoV-2 local/systemic", "200": "Immunobiology of Aging",
59
+ "202": "Fatal COVID time course", "203": "Indonesia diversity", "204": "cHSPC aging / MDS",
60
+ "300b": "DRESS / DiHS", "301": "SLE B-cell study", "302": "SLE IL-36 stim", "304": "Parse 10M cytokine",
61
+ }
62
+
63
+ # On-slide sizes (inches). Slide (b): one keyword line under the diagram leaves about 5.25 in.
64
+ A_HEIGHT_IN = 5.25
65
+ SLIDE_A_H = 5.30 # composite height: leaves room for one keyword line in the 5.7-in content area
66
+ W_FULL = style.FULL[0] # 12.3 in
67
+
68
+ # ============================================================== SVG copy with slide-size labels
69
+ FONT_R = ImageFont.truetype("/usr/share/fonts/truetype/dejavu/DejaVuSans.ttf", 100)
70
+ FONT_B = ImageFont.truetype("/usr/share/fonts/truetype/dejavu/DejaVuSans-Bold.ttf", 100)
71
+ LS = 0.5 # letter-spacing set on the outer <g> of the figure
72
+ SKEW = 0.2126
73
+
74
+
75
+ def text_w(s, fs, bold=False):
76
+ s = html.unescape(s)
77
+ return (FONT_B if bold else FONT_R).getlength(s) * fs / 100.0 + LS * len(s)
78
+
79
+
80
+ def attr(a, name):
81
+ m = re.search(rf'(?<![\w-]){name}="([^"]*)"', a)
82
+ return m.group(1) if m else None
83
+
84
+
85
+ def set_attr(a, name, val):
86
+ new, n = re.subn(rf'(?<![\w-]){name}="[^"]*"', f'{name}="{val}"', a, count=1)
87
+ assert n == 1, (name, a)
88
+ return new
89
+
90
+
91
+ def fmt(v):
92
+ return f"{v:.2f}".rstrip("0").rstrip(".")
93
+
94
+
95
+ def map_d(d, fx, fy):
96
+ """Map absolute M/L/H/V/Z path data (one coordinate group per command, as in the manuscript SVG)."""
97
+ segs = []
98
+ for cmd, args in re.findall(r"([MLHVZ])([^MLHVZ]*)", d):
99
+ nums = [float(v) for v in re.findall(r"-?\d+(?:\.\d+)?", args)]
100
+ if cmd in "ML":
101
+ assert len(nums) == 2, d
102
+ segs.append(f"{cmd}{fmt(fx(nums[0]))},{fmt(fy(nums[1]))}")
103
+ elif cmd == "H":
104
+ assert len(nums) == 1, d
105
+ segs.append(f"H{fmt(fx(nums[0]))}")
106
+ elif cmd == "V":
107
+ assert len(nums) == 1, d
108
+ segs.append(f"V{fmt(fy(nums[0]))}")
109
+ else:
110
+ segs.append("Z")
111
+ return " ".join(segs)
112
+
113
+
114
+ def d_xs(d):
115
+ toks = re.findall(r"[MLHVZ]|-?\d+(?:\.\d+)?", d)
116
+ xs, cmd, i = [], None, 0
117
+ while i < len(toks):
118
+ t = toks[i]
119
+ if t in "MLHVZ":
120
+ cmd = t
121
+ i += 1
122
+ elif cmd in "ML":
123
+ xs.append(float(t))
124
+ i += 2
125
+ elif cmd == "H":
126
+ xs.append(float(t))
127
+ i += 1
128
+ else:
129
+ i += 1
130
+ return xs
131
+
132
+
133
+ def piecewise(knots):
134
+ xs = np.array([k[0] for k in knots], float)
135
+ ys = np.array([k[1] for k in knots], float)
136
+
137
+ def X(x):
138
+ if x <= xs[0]:
139
+ return x + (ys[0] - xs[0])
140
+ if x >= xs[-1]:
141
+ return x + (ys[-1] - xs[-1])
142
+ return float(np.interp(x, xs, ys))
143
+ return X
144
+
145
+
146
+ # Panel a: widen the Expression column (+36) and the Conditioning column (+20); the main column only shifts.
147
+ X_A = piecewise([(24, 24), (232, 268), (1184, 1220), (1416, 1472)])
148
+ X_ID = piecewise([(0, 0), (1, 1)])
149
+
150
+ TOKEN = re.compile(
151
+ r'<g transform="matrix\(1,0,-0\.2126,1,(?P<gtx>[-\d.]+),0\)">(?P<ginner>.*?)</g>'
152
+ r'|<text (?P<tattrs>[^>]*)>(?P<tbody>.*?)</text>'
153
+ r'|<path (?P<pattrs>[^>]*)/>')
154
+ INNER_TEXT = re.compile(r'<text (?P<attrs>[^>]*)>(?P<body>.*?)</text>')
155
+ INNER_PATH = re.compile(r'<path (?P<attrs>[^>]*)/>')
156
+
157
+
158
+ def process_text_line(line, X, target=None, mode="c", dy=0.0, ax_fixed=None):
159
+ """Rescale one visual text line (several runs, skew groups, hat paths) about its anchor.
160
+ target: new main font size (None keeps it); mode 'c' centres on the old centre, 'l' keeps the left edge;
161
+ ax_fixed: old-coordinate centre to use instead of the measured one (re-centres a line in its box)."""
162
+ runs = []
163
+ for m in TOKEN.finditer(line):
164
+ if m.group("gtx") is not None:
165
+ t = INNER_TEXT.search(m.group("ginner"))
166
+ runs.append(dict(attrs=t.group("attrs"), body=t.group("body")))
167
+ elif m.group("tattrs") is not None:
168
+ runs.append(dict(attrs=m.group("tattrs"), body=m.group("tbody")))
169
+ for r in runs:
170
+ a = r["attrs"]
171
+ r.update(x=float(attr(a, "x")), y=float(attr(a, "y")), fs=float(attr(a, "font-size")),
172
+ bold=attr(a, "font-weight") == "700", anchor=attr(a, "text-anchor") or "start")
173
+ r["w"] = text_w(r["body"], r["fs"], r["bold"])
174
+ fs0 = max(r["fs"] for r in runs)
175
+ yb = next(r["y"] for r in runs if r["fs"] == fs0)
176
+ if any(r["anchor"] in ("middle", "end") for r in runs):
177
+ assert len(runs) == 1, line
178
+ ax_old = runs[0]["x"]
179
+ extent = (runs[0]["x"] - runs[0]["w"] / 2, runs[0]["x"] + runs[0]["w"] / 2) if runs[0]["anchor"] == "middle" \
180
+ else (runs[0]["x"] - runs[0]["w"], runs[0]["x"])
181
+ else:
182
+ x0 = min(r["x"] for r in runs)
183
+ x1 = max(r["x"] + r["w"] for r in runs)
184
+ extent = (x0, x1)
185
+ ax_old = x0 if mode == "l" else (x0 + x1) / 2
186
+ f = (target / fs0) if target else 1.0
187
+ # the measured centre goes to the mapped box centre when one is given
188
+ ax_new = X(ax_fixed) if ax_fixed is not None else X(ax_old)
189
+ yb_new = yb + dy
190
+ fx = lambda x: ax_new + (x - ax_old) * f # noqa: E731
191
+ fy = lambda y: yb_new + (y - yb) * f # noqa: E731
192
+
193
+ def fix_text(a):
194
+ x, y, fs = float(attr(a, "x")), float(attr(a, "y")), float(attr(a, "font-size"))
195
+ a = set_attr(a, "x", fmt(fx(x)))
196
+ a = set_attr(a, "y", fmt(fy(y)))
197
+ return set_attr(a, "font-size", fmt(fs * f)), fy(y)
198
+
199
+ def fix_path(a):
200
+ return set_attr(a, "d", map_d(attr(a, "d"), fx, fy))
201
+
202
+ def repl(m):
203
+ if m.group("gtx") is not None:
204
+ inner = m.group("ginner")
205
+ t = INNER_TEXT.search(inner)
206
+ ta, ynew = fix_text(t.group("attrs"))
207
+ inner = inner.replace(t.group(0), f'<text {ta}>{t.group("body")}</text>')
208
+ inner = INNER_PATH.sub(lambda p: f'<path {fix_path(p.group("attrs"))}/>', inner)
209
+ return f'<g transform="matrix(1,0,-0.2126,1,{fmt(SKEW * ynew)},0)">{inner}</g>'
210
+ if m.group("tattrs") is not None:
211
+ ta, _ = fix_text(m.group("tattrs"))
212
+ return f'<text {ta}>{m.group("tbody")}</text>'
213
+ return f'<path {fix_path(m.group("pattrs"))}/>'
214
+
215
+ new = TOKEN.sub(repl, line)
216
+ w_new = (extent[1] - extent[0]) * f
217
+ info = dict(fs_old=fs0, fs_new=fs0 * f, width_new=w_new, center_new=fx((extent[0] + extent[1]) / 2),
218
+ text=" ".join(html.unescape(r["body"]) for r in runs))
219
+ return new, info
220
+
221
+
222
+ def process_geometry_line(line, X):
223
+ def rect(m):
224
+ a = m.group(1)
225
+ x, w = float(attr(a, "x")), float(attr(a, "width"))
226
+ a = set_attr(a, "x", fmt(X(x)))
227
+ a = set_attr(a, "width", fmt(X(x + w) - X(x)))
228
+ return f"<rect {a}/>"
229
+
230
+ def circ(m):
231
+ a = m.group(1)
232
+ return f'<circle {set_attr(a, "cx", fmt(X(float(attr(a, "cx")))))}/>'
233
+
234
+ def path(m):
235
+ a = m.group(1)
236
+ d = attr(a, "d")
237
+ rigid = attr(a, "stroke") == "#FFFFFF" or d.count("M") > 1 # bar rulings and plus signs keep their size
238
+ if rigid:
239
+ xs = d_xs(d)
240
+ c = (min(xs) + max(xs)) / 2
241
+ dx = X(c) - c
242
+ return f'<path {set_attr(a, "d", map_d(d, lambda x: x + dx, lambda y: y))}/>'
243
+ return f'<path {set_attr(a, "d", map_d(d, X, lambda y: y))}/>'
244
+
245
+ line = re.sub(r"<rect ([^>]*)/>", rect, line)
246
+ line = re.sub(r"<circle ([^>]*)/>", circ, line)
247
+ line = re.sub(r"<path ([^>]*)/>", path, line)
248
+ return line
249
+
250
+
251
+ def run_line(y, parts, fill, cx, fs=19.0):
252
+ """Build a centred text line from (text, style, space_before) parts at font fs.
253
+ style: 'n' upright, 'i' italic (skew group, as in the manuscript), 'sub' upright subscript at 0.7 fs."""
254
+ fsub = round(fs * 0.7, 2)
255
+ sp = text_w(" ", fs)
256
+ widths = [text_w(t, fsub if s == "sub" else fs) for t, s, _ in parts]
257
+ total = sum(widths) + sp * sum(1 for *_, g in parts if g)
258
+ x = cx - total / 2
259
+ out = []
260
+ for (t, s, gap), w in zip(parts, widths):
261
+ x += sp if gap else 0.0
262
+ size, yy = (fsub, y + round(fs * 0.17, 1)) if s == "sub" else (fs, y)
263
+ el = (f'<text x="{fmt(x)}" y="{fmt(yy)}" font-size="{fmt(size)}" font-weight="400" fill="{fill}" '
264
+ f'letter-spacing="0.5" text-anchor="start">{t}</text>')
265
+ if s == "i":
266
+ el = f'<g transform="matrix(1,0,-0.2126,1,{fmt(SKEW * yy)},0)">{el}</g>'
267
+ out.append(el)
268
+ x += w
269
+ return "".join(out), total
270
+
271
+
272
+ # Line-specific geometry edits (1-based line numbers of the manuscript SVG); each old string must occur once.
273
+ EDITS = {
274
+ 126: [("M677.5,548 H657", "M677.5,548 H663")],
275
+ 132: [('<rect x="577" y="511" width="80" height="73"', '<rect x="571" y="511" width="92" height="73"')],
276
+ 135: [('<rect x="404" y="480" width="130" height="48"', '<rect x="398" y="480" width="142" height="48"')],
277
+ 137: [('<rect x="404" y="551" width="130" height="48"', '<rect x="398" y="548" width="142" height="60"')],
278
+ 140: [("M577,548 H560 V504 H542", "M571,548 H560 V504 H549")],
279
+ 141: [("M560,548 V575 H542", "M560,548 V578 H549")],
280
+ 142: [("M404,504 H366", "M398,504 H366")],
281
+ 143: [("M404,575 H366 V539", "M398,578 H366 V539")],
282
+ 190: [('<rect x="658" y="694" width="266" height="58"', '<rect x="658" y="694" width="266" height="64"')],
283
+ # panel b: wider reverse-sampling box for the longer last line
284
+ 262: [("H782", "H772")], 264: [("H782", "H772")], 266: [("H782", "H772")],
285
+ 270: [('<rect x="790" y="1000" width="276" height="164"', '<rect x="780" y="1000" width="296" height="164"')],
286
+ 275: [("M1066,1082 H1098", "M1076,1082 H1098")],
287
+ }
288
+ # Text lines: (new main font size, anchor mode, baseline shift in SVG units)
289
+ TEXT_A = {
290
+ 31: (21, "c", 0), 32: (21, "c", 0), 33: (21, "c", 0), 37: (21, "c", 0), 38: (21, "c", 1),
291
+ 42: (21, "c", -3), 44: (21, "c", -2),
292
+ 43: (21, "c", -5, 128.0), # manuscript line sits ~5 units right of its box centre (128); re-centred
293
+ 59: (20, "c", 0), 60: (20, "c", 0),
294
+ 61: (21, "l", 0), 75: (21, "c", 0), 76: (21, "c", 0), 77: (21, "l", 0), 83: (21, "c", 0),
295
+ 89: (21, "c", 0), 130: (21, "c", 3), 133: (21, "c", -1), 134: (21, "c", 1), 138: (21, "c", -2),
296
+ 139: (21, "c", 4), 158: (21, "c", 0), 159: (21, "c", 0), 160: (21, "l", 0), 162: (21, "l", 0),
297
+ 176: (21, "c", 0), 177: (21, "c", 0), 178: (21, "l", 0), 182: (21, "l", 0), 191: (21, "c", -1),
298
+ 192: (21, "c", 4), 195: (21, "c", -3), 198: (21, "c", 0), 199: (21, "c", 0), 208: (21, "c", 0),
299
+ 214: (21, "c", 0), 217: (21, "c", 0), 221: (21, "c", 0), 222: (21, "c", 0),
300
+ }
301
+ TEXT_B = {
302
+ 234: (19, "c", 0), 251: (19, "c", 0), 256: (19, "c", 0), 257: (19, "c", 0), 259: (19, "c", -2),
303
+ 260: (19, "c", 2), 278: (19, "c", 0), 287: (19, "c", 0), 295: (19, "c", 0), 303: (19, "c", 0),
304
+ 311: (19, "c", 0), 312: (19, "c", 0), 314: (19, "c", 0),
305
+ }
306
+ # panel a: lines 17-223 (drop the letter "a" 14-16 and the legend 224-229); panel b: 232-315 (drop letter "b")
307
+ A_LINES = list(range(17, 224))
308
+ B_LINES = [230] + list(range(232, 316)) # 230 opens the panel-b group, 315 closes it
309
+ CROP_A = (18, 110, 1478, 777) # after widening; boxes span y 116-771
310
+ CROP_B = (18, 918, 1422, 1216) # connector lines at y 926 and 1208
311
+
312
+
313
+ def build_svg(lines, rng, X, text_cfg, crop, width_in, drop_bg=True):
314
+ head = lines[:12] # xml decl .. defs .. outer <g>
315
+ x0, y0, x1, y1 = crop
316
+ vw, vh = x1 - x0, y1 - y0
317
+ h_in = width_in * vh / vw
318
+ head[1] = re.sub(r'width="[^"]*" height="[^"]*" viewBox="[^"]*"',
319
+ f'width="{width_in:.4f}in" height="{h_in:.4f}in" viewBox="{x0} {y0} {vw} {vh}"', head[1])
320
+ body = [f'<rect x="{x0}" y="{y0}" width="{vw}" height="{vh}" fill="#FFFFFF" stroke="none"/>']
321
+ infos = []
322
+ for ln in rng:
323
+ s = lines[ln - 1]
324
+ for old, new in EDITS.get(ln, []):
325
+ assert s.count(old) == 1, (ln, old)
326
+ s = s.replace(old, new)
327
+ if ln == 274: # panel b: cells differ by x_T and by the Bernoulli support draw (drawn read-out)
328
+ assert "the draw of" in s and 'font-size="18"' in s
329
+ s, w = run_line(1138.0, [("x", "i", False), ("T", "sub", False), ("and support draw differ", "n", True)],
330
+ "#5C6C74", 928.0)
331
+ infos.append(dict(line=ln, fs_old=18.0, fs_new=19.0, width_new=w, center_new=928.0,
332
+ text="x T and support draw differ (deck wording; manuscript: the draw of x T differs)"))
333
+ elif "<text" in s:
334
+ tgt, mode, dy, *fixed = text_cfg.get(ln, (None, "c", 0))
335
+ s, info = process_text_line(s, X, tgt, mode, dy, fixed[0] if fixed else None)
336
+ info["line"] = ln
337
+ infos.append(info)
338
+ elif X is not X_ID:
339
+ s = process_geometry_line(s, X)
340
+ body.append(s)
341
+ svg = "\n".join(head + body + ["</g></svg>"])
342
+ return svg, infos, h_in
343
+
344
+
345
+ def render(svg, stem, width_in, outdir=None):
346
+ """outdir: where the svg/png/pdf go (default figures/). Intermediate panels that only feed a composite go to a
347
+ temporary folder (2026-10-02: figures/ holds only what a slide shows)."""
348
+ out = FIG if outdir is None else Path(outdir)
349
+ p_svg = out / f"{stem}.svg"
350
+ p_svg.write_text(svg)
351
+ cairosvg.svg2png(bytestring=svg.encode(), write_to=str(out / f"{stem}.png"), dpi=300)
352
+ cairosvg.svg2pdf(bytestring=svg.encode(), write_to=str(out / f"{stem}.pdf"), dpi=72)
353
+ doc = fitz.open(out / f"{stem}.pdf")
354
+ wpt = doc[0].rect.width
355
+ doc.close()
356
+ assert abs(wpt - width_in * 72) < 1.0, (stem, wpt, width_in * 72)
357
+ return out / f"{stem}.png"
358
+
359
+
360
+ # ============================================================== corpus tables
361
+ def fmt_cells(v):
362
+ if v >= 1e7:
363
+ return f"{v / 1e6:.1f}M"
364
+ if v >= 1e6:
365
+ return f"{v / 1e6:.2f}M"
366
+ return f"{v / 1e3:.0f}K"
367
+
368
+
369
+ def corpus_tables():
370
+ src = json.loads(SRC_MANIFEST.read_text())
371
+ idx = json.loads(IDX_MANIFEST.read_text())
372
+ cov = json.loads(COVERAGE.read_text())
373
+ con = json.loads(CONTRACT.read_text())
374
+ base, over, raw, nsrc = (defaultdict(int) for _ in range(4))
375
+ for s in src["source_audit"]:
376
+ d = s["dataset_id"]
377
+ base[d] += int(s["base_rows"])
378
+ over[d] += int(s["overlay_rows"])
379
+ raw[d] += int(s["raw_rows"])
380
+ nsrc[d] += 1
381
+ ds = pd.DataFrame({"dataset_id": list(base)})
382
+ ds["base_rows"] = ds["dataset_id"].map(base)
383
+ ds["overlay_rows"] = ds["dataset_id"].map(over)
384
+ ds["cells"] = ds["base_rows"] + ds["overlay_rows"]
385
+ assert (ds["cells"] == ds["dataset_id"].map(raw)).all()
386
+ # cross-check against the index shards used by the run (base + overlay shards)
387
+ sh = pd.read_csv(SHARD_OFFSETS).groupby("dataset_id")["n_cells"].sum()
388
+ assert (ds.set_index("dataset_id")["cells"] == sh.reindex(ds["dataset_id"]).values).all()
389
+ ds["n_source_files"] = ds["dataset_id"].map(nsrc)
390
+ ds["label"] = ds["dataset_id"].str.split("_").str[0].map(LABELS)
391
+ assert ds["label"].notna().all()
392
+ ds = ds.sort_values("cells", ascending=False).reset_index(drop=True)
393
+ ds["rank"] = np.arange(1, len(ds) + 1)
394
+ ds["source"] = (f"{SRC_MANIFEST} :: source_audit[].base_rows + overlay_rows (= raw_rows) summed by dataset_id; "
395
+ f"equals {SHARD_OFFSETS} n_cells by dataset_id")
396
+ total = int(ds["cells"].sum())
397
+ assert len(ds) == src["n_datasets"] == idx["n_datasets"] == 22
398
+ assert total == src["logical_cells"] == idx["n_cells"] == cov["source_cells_all_splits"]
399
+ assert int(ds["base_rows"].sum()) == src["base_cells"] and int(ds["overlay_rows"].sum()) == src["overlay_cells"]
400
+ ds[["rank", "label", "cells", "base_rows", "overlay_rows", "n_source_files", "dataset_id", "source"]].to_csv(
401
+ DATA / "sec01_corpus_datasets.csv", index=False)
402
+
403
+ kq = idx["k_quotas_per_epoch"]
404
+ kk = pd.DataFrame({"K": [f"{k:,}" for k in idx["k_values"]], "k_weight": idx["k_weights"],
405
+ "recipes_per_epoch": [float(kq[str(k)]) for k in idx["k_values"]],
406
+ "recipes_per_epoch_min": [int(kq[str(k)]) for k in idx["k_values"]],
407
+ "recipes_per_epoch_max": [int(kq[str(k)]) for k in idx["k_values"]],
408
+ "kind": "registered K grid"})
409
+ kk["source"] = f"{IDX_MANIFEST} :: k_values, k_weights, k_quotas_per_epoch"
410
+ assert int(kk["recipes_per_epoch"].sum()) == idx["train_recipes_per_epoch"]
411
+
412
+ pairing = con["pairing"]
413
+ cat = con["coverage_after_topup"]
414
+ reg = pairing["registered_recipes_per_epoch"]
415
+ per_ep = np.array(pairing["total_recipe_counts_by_epoch"]) - reg
416
+ slot = pd.DataFrame(cat["slot_coverage"])
417
+ assert (np.sort(per_ep) == np.sort(slot["topup_recipes"].values)).all()
418
+ assert int(per_ep.sum()) == cat["topup_recipes"]
419
+ tu = pd.read_csv(TOPUP_CSV)
420
+ assert len(tu) == cat["topup_recipes"] and tu["is_topup"].all() and (tu["split"] == "train").all()
421
+ topup = dict(n=int(len(tu)), k_min=int(tu["k"].min()), k_max=int(tu["k"].max()),
422
+ k_median=float(tu["k"].median()), n_k_below_250=int((tu["k"] < 250).sum()),
423
+ per_epoch_mean=float(per_ep.mean()), per_epoch_min=int(per_ep.min()), per_epoch_max=int(per_ep.max()),
424
+ target_cells=int(cat["topup_target_cells"]), train_cells=int(cat["train_universe_cells"]),
425
+ coverage=float(cat["train_cell_coverage_after_topup"]),
426
+ recipes_by_epoch_min=int(min(pairing["total_recipe_counts_by_epoch"])),
427
+ recipes_by_epoch_max=int(max(pairing["total_recipe_counts_by_epoch"])))
428
+ kk = pd.concat([kk, pd.DataFrame([{
429
+ "K": "top-up", "k_weight": np.nan, "recipes_per_epoch": topup["per_epoch_mean"],
430
+ "recipes_per_epoch_min": topup["per_epoch_min"], "recipes_per_epoch_max": topup["per_epoch_max"],
431
+ "kind": f"top-up, K {topup['k_min']}-{topup['k_max']:,} (mean over 16 epochs)",
432
+ "source": f"{CONTRACT} :: pairing.total_recipe_counts_by_epoch - registered_recipes_per_epoch; {TOPUP_CSV} :: k"}])],
433
+ ignore_index=True)
434
+ kk.to_csv(DATA / "sec01_recipe_k.csv", index=False)
435
+ meta = {"n_datasets": src["n_datasets"], "cells": total, "base_cells": src["base_cells"],
436
+ "overlay_cells": src["overlay_cells"], "train_recipes_per_epoch": idx["train_recipes_per_epoch"],
437
+ "train_recipe_pool_size": idx["train_recipe_pool_size"], "max_disjoint_epochs": idx["max_disjoint_epochs"],
438
+ "split_unit": idx["split_unit"], "split_fractions": idx["split_fractions"],
439
+ "corpus_fingerprint": idx["corpus_fingerprint"], "topup": topup,
440
+ "all_members_targets": cov["all_k_member_occurrences_become_targets"],
441
+ "original_target_exposures": con["coverage_after_topup"]["original_target_exposures"],
442
+ "observed_target_cells_by_epoch": con["observed_target_cells_by_epoch"]}
443
+ return ds, kk, meta
444
+
445
+
446
+ def overlaps(fig, texts):
447
+ fig.canvas.draw()
448
+ r = fig.canvas.get_renderer()
449
+ bbs = [(t.get_text(), t.get_window_extent(r)) for t in texts if t.get_text()]
450
+ bad = []
451
+ for i in range(len(bbs)):
452
+ for j in range(i + 1, len(bbs)):
453
+ if bbs[i][1].overlaps(bbs[j][1]):
454
+ bad.append((bbs[i][0], bbs[j][0]))
455
+ return bad
456
+
457
+
458
+ def draw_corpus(fig, W, H, y0, h, ds, kk, meta, fs=12):
459
+ """Corpus panels placed in inches: two sorted dataset columns on one shared log scale (values printed,
460
+ no axis), then recipes per epoch by K. y0 = bottom of the bar area, h = its height (inches)."""
461
+ half = int(np.ceil(len(ds) / 2))
462
+ parts = [ds.iloc[:half], ds.iloc[half:]]
463
+ lo, hi = 1e4, 3e7
464
+ cols = [(2.2, 2.35), (7.2, 2.35)] # (left, width) in inches
465
+ texts = []
466
+ for (left, width), part in zip(cols, parts):
467
+ ax = fig.add_axes([left / W, y0 / H, width / W, h / H])
468
+ y = np.arange(len(part))
469
+ ax.barh(y, part["cells"], color=style.GREY, height=0.66)
470
+ for yi, v in zip(y, part["cells"]):
471
+ texts.append(ax.text(v * 1.2, yi, fmt_cells(v), va="center", ha="left", fontsize=fs, color=style.INK))
472
+ ax.set_xscale("log")
473
+ ax.set_xlim(lo, hi)
474
+ ax.set_ylim(half - 0.5, -0.5)
475
+ ax.set_yticks(y)
476
+ ax.set_yticklabels(part["label"], fontsize=fs)
477
+ texts += ax.get_yticklabels()
478
+ ax.tick_params(axis="y", length=0, pad=4)
479
+ ax.set_xticks([])
480
+ ax.minorticks_off()
481
+ for sp in ("left", "bottom"):
482
+ ax.spines[sp].set_visible(False)
483
+ t = meta["topup"]
484
+ texts.append(fig.text((cols[0][0] + cols[1][0] + cols[1][1]) / 2 / W, (y0 - 0.1) / H,
485
+ f"cells per dataset (log scale) · {meta['n_datasets']} datasets · "
486
+ f"{fmt_cells(meta['cells'])} cells · {fmt_cells(t['train_cells'])} in train split",
487
+ ha="center", va="top", fontsize=fs + 1))
488
+
489
+ ax = fig.add_axes([10.75 / W, y0 / H, 0.95 / W, h / H])
490
+ y = np.arange(len(kk))
491
+ is_top = (kk["K"] == "top-up").values
492
+ ax.barh(y[~is_top], kk.loc[~is_top, "recipes_per_epoch"], color=style.INK, height=0.62)
493
+ ax.barh(y[is_top], kk.loc[is_top, "recipes_per_epoch"], color=style.GREY, height=0.62)
494
+ vmax = kk["recipes_per_epoch"].max()
495
+ for yi, v, top in zip(y, kk["recipes_per_epoch"], is_top):
496
+ lab = f"~{v:.0f}" if top else f"{v:,.0f}"
497
+ texts.append(ax.text(v + vmax * 0.05, yi, lab, va="center", ha="left", fontsize=fs))
498
+ ax.set_ylim(len(kk) - 0.5, -0.5)
499
+ ax.set_yticks(y)
500
+ ax.set_yticklabels(kk["K"], fontsize=fs)
501
+ texts += ax.get_yticklabels()
502
+ ax.tick_params(axis="y", length=0, pad=4)
503
+ ax.set_xlim(0, vmax * 1.02)
504
+ ax.set_xticks([])
505
+ for sp in ("left", "bottom"):
506
+ ax.spines[sp].set_visible(False)
507
+ ax.set_ylabel("K cells / recipe", fontsize=fs + 1, labelpad=6)
508
+ texts.append(ax.yaxis.label)
509
+ texts.append(fig.text((10.75 + 0.5) / W, (y0 - 0.1) / H, "recipes / epoch", ha="center", va="top", fontsize=fs + 1))
510
+ return texts
511
+
512
+
513
+ def main():
514
+ FIG.mkdir(exist_ok=True)
515
+ DATA.mkdir(exist_ok=True)
516
+ lines = FIG1_SVG.read_text().split("\n")
517
+ assert len(lines) >= 316 and lines[230].startswith('<text x="24" y="914"') and 'y="813"' in lines[225]
518
+
519
+ # ---------- panel a (slide b) and panel b (slide a) deck copies
520
+ a_w = A_HEIGHT_IN * (CROP_A[2] - CROP_A[0]) / (CROP_A[3] - CROP_A[1])
521
+ svg_a, info_a, _ = build_svg(lines, A_LINES, X_A, TEXT_A, CROP_A, a_w)
522
+ render(svg_a, "sec01_fig1a_denoiser", a_w)
523
+ svg_b, info_b, b_h = build_svg(lines, B_LINES, X_ID, TEXT_B, CROP_B, W_FULL)
524
+ import tempfile
525
+ tmp = Path(tempfile.mkdtemp(prefix="sec01_")) # panel b only feeds the slide (a) composite
526
+ b_png = render(svg_b, "sec01_fig1b_inference", W_FULL, outdir=tmp)
527
+
528
+ # on-slide point size of every text line
529
+ pt_a = A_HEIGHT_IN * 72 / (CROP_A[3] - CROP_A[1])
530
+ pt_b = W_FULL * 72 / (CROP_B[2] - CROP_B[0])
531
+ rows = [dict(panel="a (slide b)", placed_in=f"{a_w:.2f} x {A_HEIGHT_IN:.2f}", pt_per_unit=pt_a, **i) for i in info_a]
532
+ rows += [dict(panel="b (slide a)", placed_in=f"{W_FULL:.2f} x {b_h:.3f}", pt_per_unit=pt_b, **i) for i in info_b]
533
+ lab = pd.DataFrame(rows)
534
+ lab["pt_on_slide"] = lab["fs_new"] * lab["pt_per_unit"]
535
+ lab = lab[["panel", "line", "text", "fs_old", "fs_new", "pt_on_slide", "width_new", "center_new", "placed_in", "pt_per_unit"]]
536
+ lab.to_csv(DATA / "sec01_fig1_label_pt.csv", index=False)
537
+
538
+ # ---------- corpus
539
+ ds, kk, meta = corpus_tables()
540
+ W = W_FULL
541
+ fig = plt.figure(figsize=(W, 2.75))
542
+ texts = draw_corpus(fig, W, 2.75, 0.45, 2.2, ds, kk, meta)
543
+ bad = overlaps(fig, texts)
544
+ assert not bad, bad
545
+ plt.close(fig) # standalone corpus panel: layout check only; the slide shows it inside sec01_slide_a
546
+
547
+ # ---------- slide (a) composite: exactly 12.3 x 5.3 in, panel b redraw on top
548
+ H = SLIDE_A_H
549
+ img = plt.imread(b_png)
550
+ fig = plt.figure(figsize=(W, H))
551
+ ax_img = fig.add_axes([0, 1 - b_h / H, 1, b_h / H])
552
+ ax_img.imshow(img, interpolation="lanczos")
553
+ ax_img.set_axis_off()
554
+ y0 = 0.45
555
+ texts = draw_corpus(fig, W, H, y0, H - b_h - 0.16 - y0, ds, kk, meta)
556
+ bad = overlaps(fig, texts)
557
+ assert not bad, bad
558
+ r = fig.canvas.get_renderer()
559
+ for t in texts: # every corpus label stays on the canvas
560
+ bb = t.get_window_extent(r)
561
+ assert bb.x0 >= 0 and bb.x1 <= W * fig.dpi and bb.y0 >= 0, t.get_text()
562
+ with plt.rc_context({"savefig.bbox": "standard"}): # keep the canvas at exactly 12.3 x 5.3 in
563
+ for ext in ("png", "pdf"):
564
+ fig.savefig(FIG / f"sec01_slide_a.{ext}", dpi=300)
565
+ plt.close(fig)
566
+
567
+ # ---------- numbers used on the slides, with sources
568
+ cfg = json.loads(CFG.read_text())
569
+ st = json.loads(STATUS.read_text())
570
+ idx = json.loads(IDX_MANIFEST.read_text())
571
+ con = json.loads(CONTRACT.read_text())
572
+ hd = cfg["model"]["hidden_dims"]
573
+ blocks = hd + hd[-2::-1]
574
+ assert "descending half of the symmetric MLP" in MODEL_PY.read_text()
575
+ meth = METHODS.read_text().split("\n")
576
+ assert "Generation used EMA weights and 50 deterministic DDIM steps ($\\eta=0$)" in meth[57]
577
+ assert "The drawn read-out is implemented in the standalone sampler that generated every set scored in this paper" in meth[98]
578
+ t = meta["topup"]
579
+ nums = [
580
+ ("n_datasets", meta["n_datasets"], f"{SRC_MANIFEST} :: n_datasets (= {IDX_MANIFEST} :: n_datasets)"),
581
+ ("corpus_cells", meta["cells"], f"{SRC_MANIFEST} :: logical_cells = base_cells + overlay_cells (= {IDX_MANIFEST} :: n_cells; = {COVERAGE} :: source_cells_all_splits)"),
582
+ ("corpus_base_cells", meta["base_cells"], f"{SRC_MANIFEST} :: base_cells"),
583
+ ("corpus_overlay_cells", meta["overlay_cells"], f"{SRC_MANIFEST} :: overlay_cells"),
584
+ ("train_split_cells", t["train_cells"], f"{CONTRACT} :: coverage_after_topup.train_universe_cells"),
585
+ ("split", f"{idx['split_unit']} {idx['split_fractions']}", f"{IDX_MANIFEST} :: split_unit, split_fractions"),
586
+ ("k_values", " ".join(str(k) for k in idx["k_values"]), f"{IDX_MANIFEST} :: k_values"),
587
+ ("registered_recipes_per_epoch", idx["train_recipes_per_epoch"], f"{IDX_MANIFEST} :: train_recipes_per_epoch"),
588
+ ("train_recipe_pool_size", idx["train_recipe_pool_size"], f"{IDX_MANIFEST} :: train_recipe_pool_size"),
589
+ ("max_disjoint_epochs", idx["max_disjoint_epochs"], f"{IDX_MANIFEST} :: max_disjoint_epochs (schedule_slots)"),
590
+ ("topup_recipes_total", t["n"], f"{CONTRACT} :: coverage_after_topup.topup_recipes (= rows of {TOPUP_CSV})"),
591
+ ("topup_recipes_per_epoch_mean_min_max", f"{t['per_epoch_mean']:.1f} {t['per_epoch_min']} {t['per_epoch_max']}", f"{CONTRACT} :: pairing.total_recipe_counts_by_epoch - pairing.registered_recipes_per_epoch"),
592
+ ("recipes_per_epoch_actual_min_max", f"{t['recipes_by_epoch_min']} {t['recipes_by_epoch_max']}", f"{CONTRACT} :: pairing.total_recipe_counts_by_epoch"),
593
+ ("topup_k_min_median_max", f"{t['k_min']} {t['k_median']:.0f} {t['k_max']}", f"{TOPUP_CSV} :: k"),
594
+ ("topup_recipes_k_below_250", t["n_k_below_250"], f"{TOPUP_CSV} :: k < 250"),
595
+ ("train_cell_coverage_after_topup", t["coverage"], f"{CONTRACT} :: coverage_after_topup.train_cell_coverage_after_topup"),
596
+ ("all_member_cells_are_targets", meta["all_members_targets"], f"{COVERAGE} :: all_k_member_occurrences_become_targets"),
597
+ ("target_cells_per_epoch_min_max", f"{min(meta['observed_target_cells_by_epoch'])} {max(meta['observed_target_cells_by_epoch'])}", f"{CONTRACT} :: observed_target_cells_by_epoch"),
598
+ ("corpus_fingerprint_matches_run", idx["corpus_fingerprint"] == st["corpus_fingerprint"] == con["pairing"]["source_corpus_fingerprint"],
599
+ f"{IDX_MANIFEST} :: corpus_fingerprint vs {STATUS} :: corpus_fingerprint and {CONTRACT} :: pairing.source_corpus_fingerprint"),
600
+ ("n_genes", cfg["data"]["n_genes"], f"{CFG} :: data.n_genes (= {STATUS} :: n_genes)"),
601
+ ("condition_dim", st["condition_dim"], f"{STATUS} :: condition_dim (= 3G+6)"),
602
+ ("parameters", st["parameters"], f"{STATUS} :: parameters"),
603
+ ("hidden_dims_descending_half", "-".join(map(str, hd)), f"{CFG} :: model.hidden_dims ({MODEL_PY} SparseDenoiserConfig: descending half of a symmetric skip MLP)"),
604
+ ("denoiser_blocks", f"{len(blocks)} blocks: {'-'.join(map(str, blocks))}", f"derived: hidden_dims + reversed(hidden_dims[:-1]); matches Fig. 1a '7 blocks + skip sums'"),
605
+ ("context_dim", cfg["model"]["context_dim"], f"{CFG} :: model.context_dim"),
606
+ ("time_embedding_dim", cfg["model"]["time_embedding_dim"], f"{CFG} :: model.time_embedding_dim"),
607
+ ("sampler", "EMA weights, 50 DDIM steps, eta 0", f"{METHODS} l.58"),
608
+ ("support_readout", "drawn (Bernoulli): keep gene g if u < sigmoid(logit); used for every scored set", f"{METHODS} l.99 (Support read-out)"),
609
+ ("ema_decay", cfg["training"]["ema_decay"], f"{CFG} :: training.ema_decay"),
610
+ ("epochs_completed", st["epochs_completed"], f"{STATUS} :: epochs_completed (= 16 disjoint schedule slots; {IDX_MANIFEST} :: schedule_slots)"),
611
+ ("status", st["status"], f"{STATUS} :: status"),
612
+ ]
613
+ assert cfg["data"]["n_genes"] == st["n_genes"]
614
+ assert st["condition_dim"] == 3 * st["n_genes"] + 6
615
+ assert st["epochs_completed"] == idx["schedule_slots"] == idx["max_disjoint_epochs"] == 16
616
+ assert idx["train_recipes_per_epoch"] * idx["schedule_slots"] == idx["train_recipe_pool_size"]
617
+ assert meta["original_target_exposures"] == sum(int(k) * int(v) for k, v in zip(
618
+ idx["k_values"], [idx["k_quotas_per_epoch"][str(k)] for k in idx["k_values"]])) * idx["schedule_slots"]
619
+ pd.DataFrame(nums, columns=["key", "value", "source"]).to_csv(DATA / "sec01_model_numbers.csv", index=False)
620
+
621
+ print(f"panel a placed {a_w:.2f} x {A_HEIGHT_IN} in, {pt_a:.4f} pt/unit; panel b {W_FULL} x {b_h:.3f} in, {pt_b:.4f} pt/unit")
622
+ for p, g in lab.groupby("panel"):
623
+ g = g.sort_values("pt_on_slide")
624
+ print(p, "min label pt", round(g["pt_on_slide"].min(), 2), "|", g.iloc[0]["text"][:40])
625
+ print("datasets", meta["n_datasets"], "cells", meta["cells"], fmt_cells(meta["cells"]))
626
+ print(ds[["label", "cells"]].to_string(index=False))
627
+ print(kk[["K", "recipes_per_epoch", "recipes_per_epoch_min", "recipes_per_epoch_max"]].to_string(index=False))
628
+ for k, v, _ in nums:
629
+ print(k, v)
630
+
631
+
632
+ if __name__ == "__main__":
633
+ main()