Archive 4 checkpoints (1-4)
Browse files- paper-releases/pbisc-diffusion/updates/20261003T174003Z-scsemi-readout-sensitivity/diffusion/dataset/server_1/model8/plans/paired_finetune_intradataset_20260927/scores/ji2025_chili/fewshot_n5/draw4_scsemi5nt/per_donor.csv +25 -0
- paper-releases/pbisc-diffusion/updates/20261003T174003Z-scsemi-readout-sensitivity/diffusion/dataset/server_1/model8/plans/paired_finetune_intradataset_20260927/scores/ji2025_chili/fewshot_n5/draw4_scsemi5nt/summary.json +533 -0
- paper-releases/pbisc-diffusion/updates/20261003T174003Z-scsemi-readout-sensitivity/diffusion/dataset/server_1/model8/plans/paired_finetune_intradataset_20260927/scores/ji2025_chili/fewshot_n5/draw4_scsemi5rt/README.md +73 -0
- paper-releases/pbisc-diffusion/updates/20261003T174003Z-scsemi-readout-sensitivity/diffusion/dataset/server_1/model8/plans/paired_finetune_intradataset_20260927/scores/ji2025_chili/fewshot_n5/draw4_scsemi5rt/contrast.csv +14 -0
paper-releases/pbisc-diffusion/updates/20261003T174003Z-scsemi-readout-sensitivity/diffusion/dataset/server_1/model8/plans/paired_finetune_intradataset_20260927/scores/ji2025_chili/fewshot_n5/draw4_scsemi5nt/per_donor.csv
ADDED
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| 1 |
+
arm,donor,group,n_generated_cells,n_observed_cells,n_reference_cells,gen_T cell,obs_T cell,gen_B cell,obs_B cell,gen_Monocyte,obs_Monocyte,gen_NK cell,obs_NK cell,gen_DC,obs_DC,gen_Other,obs_Other,comp_l1,comp_l1_obs_loo_null,pb_r,pb_own_rank,pb_top1,precision,coverage,precision_depth_matched,coverage_depth_matched,mono_pct_gen,mono_pct_obs,median_umi_gen,median_umi_obs
|
| 2 |
+
scsemi5nt,N032_AC,AC,1500,7350,150,0.446,0.5891156462585034,0.058,0.10979591836734694,0.32866666666666666,0.17551020408163265,0.09466666666666666,0.04707482993197279,0.06666666666666667,0.025714285714285714,0.006,0.0527891156462585,0.4834013605442177,0.4621669292035723,0.8985654660582376,10,False,0.9866666666666667,0.9266666666666666,0.9933333333333333,0.7133333333333334,32.86666666666667,17.551020408163264,922.0,437.0
|
| 3 |
+
scsemi5nt,N038_BC,BC,1500,2801,150,0.73,0.5608711174580507,0.04666666666666667,0.0046411995715815784,0.07666666666666666,0.16565512317029632,0.124,0.2170653338093538,0.018666666666666668,0.034273473759371655,0.004,0.017493752231345947,0.4223086992740688,0.39821708362255787,0.9229600452907039,5,False,0.9933333333333333,0.7133333333333334,0.98,0.7666666666666667,7.666666666666666,16.565512317029633,921.0,1317.0
|
| 4 |
+
scsemi5nt,N038_AC,AC,1500,3976,150,0.7106666666666667,0.6830985915492958,0.04533333333333334,0.00829979879275654,0.07733333333333334,0.1290241448692153,0.14133333333333334,0.12072434607645875,0.022,0.03194164989939638,0.0033333333333333335,0.026911468812877263,0.17042119382964457,0.544696017292601,0.9287452258684599,3,False,0.9933333333333333,0.84,0.9933333333333333,0.78,7.733333333333333,12.90241448692153,919.0,910.5
|
| 5 |
+
scsemi5nt,N055_AC,AC,1500,4308,150,0.6913333333333334,0.340297121634169,0.056666666666666664,0.07799442896935933,0.11733333333333333,0.32474466109563604,0.09866666666666667,0.2051996285979573,0.005333333333333333,0.0060352831940575676,0.030666666666666665,0.0457288765088208,0.7020724233983288,0.2380379337775038,0.9193591286196734,12,False,0.96,0.5666666666666667,0.92,0.8066666666666666,11.733333333333333,32.47446610956361,921.0,1139.5
|
| 6 |
+
scsemi5nt,N136_TOL,TOL,1500,759,150,0.8366666666666667,0.48616600790513836,0.025333333333333333,0.10013175230566534,0.09333333333333334,0.19104084321475626,0.020666666666666667,0.0922266139657444,0.018,0.0013175230566534915,0.006,0.12911725955204217,0.7343662714097496,0.3772248941314246,0.7872728817748643,15,False,0.78,0.44666666666666666,0.8066666666666666,0.21333333333333335,9.333333333333334,19.104084321475625,921.0,1837.0
|
| 7 |
+
scsemi5nt,N136_FU1,FU1,1500,2927,150,0.6893333333333334,0.4246668944311582,0.08066666666666666,0.14724974376494704,0.07066666666666667,0.19337205329689103,0.138,0.09531943969935087,0.016666666666666666,0.0023915271609156134,0.004666666666666667,0.13700034164673727,0.6432442774171507,0.4066704938920718,0.8312651059837528,6,False,0.94,0.4866666666666667,0.9733333333333334,0.44,7.066666666666667,19.3372053296891,919.5,1501.0
|
| 8 |
+
scsemi5nt,N138_TOL,TOL,1500,5129,150,0.7086666666666667,0.13803860401637746,0.048666666666666664,0.02807564827451745,0.06866666666666667,0.5878338857477091,0.13666666666666666,0.17703255995320724,0.036,0.006044063170208618,0.0013333333333333333,0.06297523883798012,1.2423500357444597,0.7408047250846135,0.881324446372815,23,False,0.9666666666666667,0.54,0.9733333333333334,0.4666666666666667,6.866666666666667,58.78338857477091,922.0,1117.0
|
| 9 |
+
scsemi5nt,N138_FU1,FU1,1500,2107,150,0.7333333333333333,0.2728998576174656,0.05266666666666667,0.04841006169909824,0.102,0.4831514000949217,0.09,0.1134314190792596,0.01,0.005220692928334125,0.012,0.07688656858092074,0.9389387755102041,0.5503179306259297,0.8852048440238813,21,False,0.94,0.35333333333333333,0.94,0.44,10.2,48.31514000949217,920.0,1446.0
|
| 10 |
+
scsemi5nt,N128_BC,BC,1500,3902,150,0.7073333333333334,0.5158892875448488,0.05,0.06817016914402871,0.07866666666666666,0.29420809841107126,0.12333333333333334,0.07842132239876987,0.029333333333333333,0.03331624807790876,0.011333333333333334,0.00999487442337263,0.4753890312660175,0.2621662754087492,0.907555101733639,5,False,0.9933333333333333,0.8466666666666667,0.9933333333333333,0.7666666666666667,7.866666666666666,29.420809841107125,919.0,1088.0
|
| 11 |
+
scsemi5nt,N128_AC,AC,1500,2713,150,0.724,0.5488389237007003,0.043333333333333335,0.06524143015112421,0.064,0.2790269074824917,0.13266666666666665,0.07077036490969407,0.03,0.029487652045705862,0.006,0.006634721710283818,0.4751394520211328,0.28418849581307837,0.9004517863428894,10,False,0.9933333333333333,0.6733333333333333,0.9733333333333334,0.6466666666666666,6.4,27.90269074824917,921.0,1181.0
|
| 12 |
+
scsemi5nt,N147_TOL,TOL,1500,3210,150,0.284,0.44205607476635517,0.024666666666666667,0.00809968847352025,0.5906666666666667,0.4193146417445483,0.042666666666666665,0.07102803738317758,0.04666666666666667,0.0065420560747663555,0.011333333333333334,0.0529595015576324,0.4560872274143302,0.33533863234847805,0.8820708100083923,2,False,0.9733333333333334,0.38,0.94,0.76,59.06666666666667,41.93146417445483,924.0,1461.5
|
| 13 |
+
scsemi5nt,N150_BC,BC,1500,2433,150,0.7206666666666667,0.802301685162351,0.04133333333333333,0.02301685162351007,0.078,0.1385121249486231,0.12533333333333332,0.02178380600082203,0.02266666666666667,0.005754212905877518,0.012,0.008631319358816275,0.2842942868886149,0.742163251171083,0.9298303972656696,1,True,1.0,0.35333333333333333,0.98,0.8933333333333333,7.8,13.851212494862311,922.0,1629.0
|
| 14 |
+
scsemi5nt,N159_BC,BC,1500,3779,150,0.49266666666666664,0.6996559936491136,0.0,0.018523418893887273,0.36666666666666664,0.08123842286319131,0.0,0.173590897062715,0.0,0.014024874305371792,0.14066666666666666,0.01296639322572109,0.8262570344888419,0.5355058623582558,0.7695789696467159,6,False,0.22,0.64,0.44666666666666666,0.30666666666666664,36.666666666666664,8.123842286319132,919.0,1045.0
|
| 15 |
+
scsemi5nt,N001_TOL,TOL,1500,5658,150,0.41533333333333333,0.51926475786497,0.048,0.03375751148815836,0.382,0.21067515022976316,0.124,0.2163308589607635,0.02266666666666667,0.003711558854718982,0.008,0.016260162601626018,0.4090448921880524,0.23122529866547606,0.9288091333526107,8,False,0.9866666666666667,0.8133333333333334,0.9933333333333333,0.7333333333333333,38.2,21.067515022976316,921.0,787.5
|
| 16 |
+
scsemi5nt,N001_FU1,FU1,1500,4547,150,0.7593333333333333,0.29601935341983726,0.03933333333333333,0.06575764240158347,0.106,0.48823400043985044,0.06266666666666666,0.13591378931163403,0.012,0.0010996261271167802,0.020666666666666667,0.012975588299978007,0.9638108643061359,0.45731464040137537,0.8585681046942812,17,False,0.98,0.6533333333333333,0.9533333333333334,0.23333333333333334,10.6,48.823400043985046,921.0,1165.0
|
| 17 |
+
scsemi5nt,N012_TOL,TOL,1500,6709,150,0.7086666666666667,0.34759278581010583,0.04,0.07884930690117753,0.086,0.4672827545088687,0.14333333333333334,0.08570576837084513,0.017333333333333333,0.0005962140408406618,0.004666666666666667,0.01997317036816217,0.8708771302230836,0.46458253906049324,0.9015891053866947,14,False,0.98,0.5733333333333334,0.98,0.4666666666666667,8.6,46.72827545088687,922.0,1193.0
|
| 18 |
+
scsemi5nt,N012_FU1,FU1,1500,4369,150,0.6566666666666666,0.35889219501029984,0.06066666666666667,0.19249256122682537,0.11133333333333334,0.3126573586633097,0.10333333333333333,0.10849164568551156,0.006666666666666667,0.000686655985351339,0.06133333333333333,0.02677958342870222,0.6766164644846265,0.3826182560206709,0.8942863576444918,21,False,0.8866666666666667,0.38666666666666666,0.88,0.5,11.133333333333335,31.265735866330967,922.0,1299.0
|
| 19 |
+
scsemi5nt,N018_BC,BC,1500,3045,150,0.422,0.32939244663382594,0.05733333333333333,0.042692939244663386,0.368,0.2889983579638752,0.12333333333333334,0.2653530377668309,0.019333333333333334,0.05812807881773399,0.01,0.015435139573070607,0.37249917898193763,0.3140386913150764,0.9431851300233419,1,True,0.9466666666666667,0.88,0.9666666666666667,0.9333333333333333,36.8,28.899835796387517,919.5,995.0
|
| 20 |
+
scsemi5nt,N018_AC,AC,1500,3520,150,0.792,0.5900568181818182,0.04666666666666667,0.03664772727272727,0.07266666666666667,0.16164772727272728,0.05,0.14914772727272727,0.035333333333333335,0.04261363636363636,0.0033333333333333335,0.019886363636363636,0.42392424242424237,0.35359336597075297,0.8772942057722715,6,False,1.0,0.64,0.9866666666666667,0.6333333333333333,7.2666666666666675,16.164772727272727,920.0,858.0
|
| 21 |
+
scsemi5nt,N022_TOL,TOL,1500,3651,150,0.6106666666666667,0.4864420706655711,0.09933333333333333,0.03697617091207888,0.09333333333333334,0.045740892906053134,0.17333333333333334,0.4182415776499589,0.012666666666666666,0.0,0.010666666666666666,0.01259928786633799,0.4936817310325938,0.6126085550533944,0.9153390611713116,6,False,0.96,0.58,0.96,0.58,9.333333333333334,4.574089290605313,920.0,1410.0
|
| 22 |
+
scsemi5nt,N022_FU1,FU1,1500,2463,150,0.6673333333333333,0.48477466504263095,0.016,0.048721071863580996,0.12533333333333332,0.20259845716605765,0.182,0.25334957369062117,0.0026666666666666666,0.0,0.006666666666666667,0.010556232237109216,0.37045066991473813,0.2794897358888386,0.9238346326454137,2,False,0.9066666666666666,0.5133333333333333,0.82,0.6533333333333333,12.533333333333333,20.259845716605763,921.0,1459.0
|
| 23 |
+
scsemi5nt,N035_TOL,TOL,1500,1598,150,0.7393333333333333,0.2853566958698373,0.052,0.016896120150187734,0.11133333333333334,0.31101376720901125,0.082,0.3404255319148936,0.007333333333333333,0.01376720901126408,0.008,0.03254067584480601,0.9781610346266165,0.43295172123362446,0.8839286055636905,17,False,0.98,0.2866666666666667,0.98,0.34,11.133333333333335,31.101376720901126,921.0,1855.5
|
| 24 |
+
scsemi5nt,N043_TOL,TOL,1500,2074,150,0.748,0.3548698167791707,0.04533333333333334,0.05737704918032787,0.1,0.04580520732883317,0.09666666666666666,0.4811957569913211,0.008666666666666666,0.0028929604628736743,0.0013333333333333333,0.05785920925747348,0.9061973641915783,0.6906672211370121,0.8969731095103967,14,False,0.9866666666666667,0.5466666666666666,0.9866666666666667,0.44666666666666666,10.0,4.580520732883317,920.0,1315.5
|
| 25 |
+
scsemi5nt,N043_FU1,FU1,1500,3437,150,0.6726666666666666,0.1638056444573756,0.078,0.06779167878964212,0.06866666666666667,0.5728833284841431,0.15933333333333333,0.14896712249054408,0.015333333333333332,0.0034914169333721268,0.006,0.043060808844922895,1.082554941324799,0.6384700163445262,0.7977692473787463,24,False,0.94,0.37333333333333335,0.9666666666666667,0.04666666666666667,6.866666666666667,57.28833284841431,920.0,1422.0
|
paper-releases/pbisc-diffusion/updates/20261003T174003Z-scsemi-readout-sensitivity/diffusion/dataset/server_1/model8/plans/paired_finetune_intradataset_20260927/scores/ji2025_chili/fewshot_n5/draw4_scsemi5nt/summary.json
ADDED
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@@ -0,0 +1,533 @@
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|
| 1 |
+
{
|
| 2 |
+
"schema": "paired_ft_scores.v1",
|
| 3 |
+
"dataset": "ji2025_chili",
|
| 4 |
+
"written_utc": "2026-10-03T14:45:07.152218+00:00",
|
| 5 |
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|
| 6 |
+
"/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_finetune_intradataset_20260927/tools/score_ft.py",
|
| 7 |
+
"--dataset",
|
| 8 |
+
"ji2025_chili",
|
| 9 |
+
"--out",
|
| 10 |
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|
| 11 |
+
"--threads",
|
| 12 |
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"6",
|
| 13 |
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"--donors",
|
| 14 |
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"/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_finetune_intradataset_20260927/data/ji2025_chili/fewshot_n5/draw4/test_samples.txt",
|
| 15 |
+
"--case-groups",
|
| 16 |
+
"TOL,FU1",
|
| 17 |
+
"--control-groups",
|
| 18 |
+
"BC,AC",
|
| 19 |
+
"--arm",
|
| 20 |
+
"scsemi5nt=/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_finetune_intradataset_20260927/generated/ji2025_chili/fewshot_n5/draw4/scsemi5nt__raw.npz"
|
| 21 |
+
],
|
| 22 |
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|
| 23 |
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"scsemi5nt"
|
| 24 |
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|
| 25 |
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|
| 26 |
+
"N032_AC",
|
| 27 |
+
"N038_BC",
|
| 28 |
+
"N038_AC",
|
| 29 |
+
"N055_AC",
|
| 30 |
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"N136_TOL",
|
| 31 |
+
"N136_FU1",
|
| 32 |
+
"N138_TOL",
|
| 33 |
+
"N138_FU1",
|
| 34 |
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"N128_BC",
|
| 35 |
+
"N128_AC",
|
| 36 |
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"N147_TOL",
|
| 37 |
+
"N150_BC",
|
| 38 |
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"N159_BC",
|
| 39 |
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"N001_TOL",
|
| 40 |
+
"N001_FU1",
|
| 41 |
+
"N012_TOL",
|
| 42 |
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"N012_FU1",
|
| 43 |
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"N018_BC",
|
| 44 |
+
"N018_AC",
|
| 45 |
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"N022_TOL",
|
| 46 |
+
"N022_FU1",
|
| 47 |
+
"N035_TOL",
|
| 48 |
+
"N043_TOL",
|
| 49 |
+
"N043_FU1"
|
| 50 |
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|
| 51 |
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|
| 52 |
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|
| 53 |
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"cache": "/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_finetune_intradataset_20260927/scoring_cache/ji2025_chili",
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| 54 |
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|
| 56 |
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|
| 57 |
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|
| 58 |
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|
| 59 |
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|
| 61 |
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| 62 |
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|
| 63 |
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| 64 |
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| 65 |
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|
| 69 |
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|
| 70 |
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| 71 |
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|
| 72 |
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| 73 |
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| 74 |
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| 75 |
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|
| 76 |
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|
| 77 |
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|
| 78 |
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|
| 79 |
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|
| 80 |
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|
| 81 |
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|
| 82 |
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| 83 |
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|
| 84 |
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|
| 85 |
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| 86 |
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|
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| 112 |
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| 113 |
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| 114 |
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| 115 |
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| 116 |
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| 117 |
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| 118 |
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| 132 |
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| 133 |
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| 136 |
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|
| 137 |
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|
| 138 |
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|
| 139 |
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false,
|
| 140 |
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|
| 141 |
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| 142 |
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|
| 143 |
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|
| 144 |
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|
| 145 |
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|
| 146 |
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|
| 147 |
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|
| 148 |
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|
| 149 |
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|
| 150 |
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|
| 151 |
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|
| 152 |
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| 153 |
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| 154 |
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|
| 155 |
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| 156 |
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| 157 |
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| 158 |
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| 159 |
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|
| 160 |
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|
| 161 |
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|
| 162 |
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| 163 |
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| 164 |
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| 165 |
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| 166 |
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|
| 167 |
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|
| 168 |
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},
|
| 169 |
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"deg_definition": {
|
| 170 |
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"enabled": true,
|
| 171 |
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"score": "top-50 DEG overlap per cell type (benchmark total_top50_overlap, Welch backend)",
|
| 172 |
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"source": "/home/sj_server_1/PBISC/immun-pbmc-fm/bulk2sc-paper/scripts/evaluate_generated_vs_truth.py",
|
| 173 |
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"functions": [
|
| 174 |
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|
| 175 |
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|
| 176 |
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"jaccard"
|
| 177 |
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],
|
| 178 |
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| 179 |
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|
| 180 |
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|
| 181 |
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|
| 182 |
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|
| 183 |
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|
| 184 |
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|
| 185 |
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|
| 186 |
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|
| 187 |
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|
| 188 |
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|
| 189 |
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| 190 |
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|
| 193 |
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| 194 |
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|
| 195 |
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|
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|
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|
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|
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|
| 233 |
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}
|
| 234 |
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},
|
| 235 |
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|
| 236 |
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},
|
| 237 |
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|
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|
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paper-releases/pbisc-diffusion/updates/20261003T174003Z-scsemi-readout-sensitivity/diffusion/dataset/server_1/model8/plans/paired_finetune_intradataset_20260927/scores/ji2025_chili/fewshot_n5/draw4_scsemi5rt/README.md
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# score_ft.py output: ji2025_chili, 24 scored donors
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Arms: scsemi5rt. Every arm is scored on the same donors against the same observed reference.
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## Inputs and fixed contracts
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- Observed reference: `/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_finetune_intradataset_20260927/scoring_cache/ji2025_chili/reference.npz` (sha 19c30f56db69), built from datadir:/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_finetune_intradataset_20260927/data/ji2025_chili;
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observed cells sum exactly to the features pseudobulk of every donor. Observed labels: /home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_finetune_intradataset_20260927/scoring_cache/ji2025_chili/observed_labels/labels/labels.parquet.
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- Generated cells: `generated_counts` read out once with Poisson(seed 20260916) over the **whole NPZ in row order**
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(`poisson_readout.poisson_integerise`), then the scored donors' rows. These integer counts are used for labels, embedding,
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depth and the contrast. Pseudobulk uses the summed `generated_counts` (rates), as `score_generated.py`.
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- Labels: frozen f01common scANVI (`predict_scanvi.py`, CPU, zero query epochs), six-type gate ['T cell', 'B cell', 'Monocyte', 'NK cell', 'DC', 'Other']; query genes =
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the 1,006-gene annotation list minus genes the dataset's sc assay did not measure in every sample (1004 genes).
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- Scoring genes: 6k panel genes measured by both assays in every sample of the dataset (5752 genes).
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## Definitions
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1. **Composition**: fraction of each donor's cells per six-type label (all generated cells; all observed QC cells).
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`comp_l1` = sum over the six labels of |generated - observed| (immicro_common.l1). `comp_l1_obs_loo_null` = L1 of the
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donor's observed composition to the mean of the *other scored donors'* observed compositions. `composition_top1` =
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fraction of donors whose generated composition is closest (L1) to their own observed composition.
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2. **Pseudobulk**: `pb_r` = Pearson r of CPM-log1p(summed generated_counts) vs CPM-log1p(observed pseudobulk) on the scoring
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genes (evaluate_realbulk.cpm_log1p / paired_r). `pb_top1` = the donor's generated pseudobulk is closest (Pearson) to its own
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observed pseudobulk among the 24 scored donors (immicro_common.retrieval = evaluate_realbulk.top1 arithmetic).
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3. **Precision / coverage / density** (stage_b_embed.py functions): per-cell CP10K over the scoring genes + log1p; PCA-50
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(randomized, random_state 20260925) and k = 10 real-real k-NN balls fitted on **R1 of the scored donors only**.
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Reference rule (independent of fold and arm): per donor, cells in canonical order (library_id+barcode), one
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permutation from `default_rng([20260925, uint64(sha256(donor)[:8])])`; R1 = first n, R2 = next n,
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n = min(150, n_cells // 2) (3600 R1 cells here). Generated query: per donor n cells (the donor's R1 size),
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without replacement, `default_rng([20260926, same key])`. Precision = fraction of generated cells inside any R1 ball
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(Kynkaanniemi 2019); coverage = fraction of R1 cells whose ball holds a generated cell; density = Naeem 2020.
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Per-donor precision = that donor's generated cells; per-donor coverage = that donor's R1 cells (the pooled values are
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their n-weighted means; plain means when every donor has 150 reference cells). R2 (held-out real cells of the same donors) is the
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perfect-generator control: precision 0.9975, coverage 1.0000.
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**Depth matched**: stage_b_embed depth matching run pairwise (R1 vs this arm): per donor and within-donor rank of detected
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genes, both cells are thinned by UMI sampling without replacement to the smaller detected-gene count; PCA kept from
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un-thinned R1, radii recomputed on thinned R1; fresh rng(20260929) per arm. R2 control: precision
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0.9972, coverage 1.0000.
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4. **Monocyte %** = 100 x Monocyte fraction (all cells) per donor; **median UMI per cell** = median over cells of the
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Poisson-read (generated) / observed counts summed over the scoring genes (per donor, and pooled).
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5. **Group contrast** (T, B, Monocyte, NK): case groups ['TOL', 'FU1'] (n = 14) vs control groups ['BC', 'AC'] (n = 10); rule: explicit --case-groups / --control-groups; groups from features groups.
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Genes per type = scoring genes detected (count > 0) in >= 1 % of the scored donors' observed
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cells of that type. Primary statistic `mean_cp10k`: per-cell CP10K over the scoring genes; per donor the mean over its
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cells of the type (donors with >= 1 such cell); group mean = mean over the group's donors (donor-balanced);
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logFC = log2(case mean + 1) - log2(control mean + 1). Secondary `pseudobulk_log1p_cpm`: the SLE benchmark evaluator's
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statistic (donor x type summed counts, log1p CPM over the scoring genes, mean case - mean control;
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evaluate_generated_vs_truth.group_log_fold_change). Both are computed on the generated cells (their frozen labels) and on
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the observed cells; `r_generated` = Pearson r of the two logFC vectors. Broadcast baseline `r_broadcast`: the same
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observed vector against the logFC of the input bulk (condition NPZ `bulk_counts` of the arm, scoring genes, per-donor
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CP10K resp. log1p CPM, group means). `partial_r_generated_given_broadcast`: r of the OLS residuals of observed and
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generated logFC on the bulk logFC (residual_specificity.py).
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6. **Top-50 DEG overlap** (contrast.csv rows `statistic = welch_top50_deg`; summary `deg_top50`): the SLE benchmark's score (`total_top50_overlap` of
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`bulk2sc-paper/scripts/evaluate_generated_vs_truth.py`, Welch backend: the "top-50 DEG 81 / 84" of the final model), run
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with the evaluator's own functions on the same donor x type pseudobulks as the contrast. Per cell type, observed and
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generated separately: donor x type summed counts on all 5752 scoring genes (donors of the two groups with
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>= 1 cell of the type) -> `welch_bh_deg` (log1p CPM, two-sided Welch t-test case vs control, Benjamini-Hochberg over the
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genes with a defined p-value; needs >= 2 donors per group) -> `top_deg_genes` (FDR < 0.05, descending |logFC|,
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first 50; shorter when fewer genes pass). `top50_overlap` = |observed list & generated list|; `top50_jaccard`
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the evaluator's Jaccard. Summary `sum` = total over the scored types (the quantity reported as 81), `max` = the sum of
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the observed list lengths (the "of 262"), `sum_4type` = T + B + Monocyte + NK. A type is scored when its observed test
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is defined; an arm whose generated test is undefined for a scored type gets overlap 0. Types: T cell, B cell, Monocyte, NK cell, DC
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(aggregates: /home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_finetune_intradataset_20260927/scoring_cache/ji2025_chili/deg_reference.npz).
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**Broadcast analogue** (`top50_overlap_broadcast`, as `sle_broadcast.py` `broadcast_input_bulk`; not part of the
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published benchmark): the same test on the arm's condition bulk_counts (scoring genes, the 14 + 10
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donors), one whole-PBMC top-50 list, compared with every type's observed list.
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## Files
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- `per_donor.csv`: one row per arm x donor (all per-donor quantities above).
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- `summary.json`: per arm the donor means / pooled values, provenance (NPZ sha, receipt check, generation metadata,
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Poisson nnz of the whole NPZ, annotation contract), and the reference block (PCA, R2 control).
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- `contrast.csv`: per arm x cell type x statistic (`mean_cp10k`, `pseudobulk_log1p_cpm`: logFC r; `welch_top50_deg`:
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top-50 DEG overlap, T / B / Monocyte / NK / DC; columns of the other kind are empty).
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- `arms/<arm>/labels/` (predict_scanvi.py labels + manifest), `arms/<arm>/generated_cells.parquet` (NPZ row, donor, label,
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UMI on the scoring genes, P/C subsample flag), `arms/<arm>/deg_top50_lists.csv` (observed, generated and broadcast
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top-50 gene lists, Ensembl ids, rank order).
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paper-releases/pbisc-diffusion/updates/20261003T174003Z-scsemi-readout-sensitivity/diffusion/dataset/server_1/model8/plans/paired_finetune_intradataset_20260927/scores/ji2025_chili/fewshot_n5/draw4_scsemi5rt/contrast.csv
ADDED
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arm,celltype,statistic,n_genes,r_generated,r_broadcast,partial_r_generated_given_broadcast,r_generated_vs_broadcast,n_case_donors_obs,n_control_donors_obs,n_case_donors_gen,n_control_donors_gen,n_cells_obs,n_cells_gen,deg_scored,top50_overlap,top50_jaccard,obs_top_list_size,gen_top_list_size,n_sig_obs,n_sig_gen,top50_overlap_broadcast,top50_jaccard_broadcast,broadcast_top_list_size,n_sig_broadcast
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scsemi5rt,T cell,mean_cp10k,3051,0.1313361277968531,0.22058892790303236,0.04689908200029386,0.4058651129691971,14,10,14,10,38484,24040,,,,,,,,,,,
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scsemi5rt,T cell,pseudobulk_log1p_cpm,3051,0.0774543747457402,0.22354974300191646,0.019925586114484306,0.2626480514483466,14,10,14,10,38484,24040,,,,,,,,,,,
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scsemi5rt,B cell,mean_cp10k,3274,-0.06753940127469833,0.1250583519693801,-0.12155167696768589,0.35971577348542716,14,10,14,9,5290,1490,,,,,,,,,,,
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scsemi5rt,B cell,pseudobulk_log1p_cpm,3274,-0.019470409174669037,0.03179791067265472,-0.02553368963852234,0.17752719370774805,14,10,14,9,5290,1490,,,,,,,,,,,
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scsemi5rt,Monocyte,mean_cp10k,3154,0.2950512496617287,0.3600824414237215,0.17553095660224538,0.40323666970097605,14,10,14,10,24894,4766,,,,,,,,,,,
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scsemi5rt,Monocyte,pseudobulk_log1p_cpm,3154,0.1948042630823925,0.34831134154512483,0.12396467291986936,0.23501067688587954,14,10,14,10,24894,4766,,,,,,,,,,,
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scsemi5rt,NK cell,mean_cp10k,3068,0.06488791774606674,0.19608672297995844,-0.016183238775601006,0.40491210461558974,14,10,14,9,13678,3588,,,,,,,,,,,
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scsemi5rt,NK cell,pseudobulk_log1p_cpm,3068,0.04770054934524398,0.07191205216182345,0.0336469701638475,0.20671877560256477,14,10,14,9,13678,3588,,,,,,,,,,,
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scsemi5rt,T cell,welch_top50_deg,5752,,,,,14,10,14,10,38484,24040,True,0,0.0,50,0,296,0,0,0.0,2,2
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scsemi5rt,B cell,welch_top50_deg,5752,,,,,14,10,14,9,5290,1490,True,0,0.0,21,0,21,0,0,0.0,2,2
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scsemi5rt,Monocyte,welch_top50_deg,5752,,,,,14,10,14,10,24894,4766,True,0,0.0,50,0,238,0,0,0.0,2,2
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scsemi5rt,NK cell,welch_top50_deg,5752,,,,,14,10,14,9,13678,3588,True,0,0.0,18,0,18,0,0,0.0,2,2
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scsemi5rt,DC,welch_top50_deg,5752,,,,,12,10,14,9,1186,979,True,0,0.0,50,0,216,0,0,0.0,2,2
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