Update knowledge graph: 70k+ relations, 55k+ quoted full-text sentences, GSE311770 co-expression, and canonical pathways

README.md

@@ -38,16 +38,17 @@ database entry, and where licensing allows, the sentence itself.
 
 | | Count |
 |---|---|
-| Entities | 16,122 |
-| Relations | 59,540 |
-| Measured relations | 30,174 |
-| Evidence rows | 148,200 |
-| Quoted sentences | 23,993 |
+| Entities | 16,135 |
+| Relations | 68,006 |
+| Measured relations | 38,642 |
+| Evidence rows | 191,638 |
+| Quoted sentences | 55,976 |
 
 A further 2,464 relations resting only on WHO ICTRP records are published
-separately under WHO's terms (see [Licensing](#licensing)).
+separately under WHO's terms (see [Licensing](#licensing)), bringing the total
+to 70,470 relations.
 
-Snapshot of 7 November 2026. Research data, not medical advice.
+Snapshot of 8 November 2026. Research data, not medical advice.
 
 ## Contents
 
@@ -55,16 +56,18 @@ Snapshot of 7 November 2026. Research data, not medical advice.
 event is the node of the disease or finding it names, so "herpes zoster" in
 a trial's safety table and in a paper is one node), 4,223 targets (genes and
 proteins), 1,577 trials, 1,355 drugs, 1,201 interventions (procedures,
-phototherapy and combination regimens), 873 biomarkers, 23 outcomes, and a
-few pathways, mechanisms, cell types and phenotypes.
+phototherapy and combination regimens), 873 biomarkers, 23 outcomes, 15
+canonical biological pathways, 6 cell types, and related mechanisms and phenotypes.
 
 **Relations** (`relations`): changes 28,592 · associated_with 19,394 ·
-treats 2,792 · tested_in 2,735 · inhibits 1,774 · causes 1,742 ·
-investigates 1,577 · activates 857 · combined_with 61 · targets 6 ·
-expressed_in 6 · occurs_in 4.
-
-**Evidence** (`evidence`): one row per source of a relation. A relation
-stated by several papers has several rows.
+co_expressed_with 8,367 · treats 3,587 · tested_in 2,735 · inhibits 1,774 · causes 1,742 ·
+investigates 1,577 · activates 857 · participates_in 75 · combined_with 61 ·
+expressed_in 36 · targets 8 · occurs_in 4.
+
+**Evidence** (`evidence`): one row per source of a relation. Incorporates
+full-text extraction across 2,712 PMC papers with BioRED BiomedBERT and
+direct human vitiligo skin punch biopsy co-expression measurements (GSE311770, N=105).
+A relation stated by several papers or measurements has several rows.
 
 ## Schema
 

entities.jsonl

@@ -10,7 +10,7 @@
 {"id": 10, "kind": "target", "key": "rarb", "name": "RARB", "aliases": ["RARB"], "external_ids": {"ensembl": "ENSG00000077092"}}
 {"id": 11, "kind": "target", "key": "rara", "name": "RARA", "aliases": ["RARA"], "external_ids": {"ensembl": "ENSG00000131759"}}
 {"id": 12, "kind": "drug", "key": "abatacept", "name": "Abatacept", "aliases": ["ABATACEPT", "Abatacept", "Abatacept (genetical recombination)", "Abatacept recombinant", "BMS-188667", "CTLA4-IGG4M", "RG-1046", "RG-2077", "Orencia"], "external_ids": {"opentargets": "CHEMBL1201823", "disease_id": "EFO_0004208"}}
-{"id": 13, "kind": "target", "key": "cd80", "name": "CD80", "aliases": ["CD80", "CD80 molecule"], "external_ids": {"ensembl": "ENSG00000121594", "opentargets": "ENSG00000121594", "disease_id": "EFO_0004208", "gwas_variant": "rs148136154"}}
+{"id": 13, "kind": "target", "key": "cd80", "name": "CD80", "aliases": ["CD80", "CD80 molecule", "Cd80"], "external_ids": {"ensembl": "ENSG00000121594", "opentargets": "ENSG00000121594", "disease_id": "EFO_0004208", "gwas_variant": "rs148136154"}}
 {"id": 14, "kind": "target", "key": "cd86", "name": "CD86", "aliases": ["CD86"], "external_ids": {"ensembl": "ENSG00000114013"}}
 {"id": 15, "kind": "drug", "key": "ritlecitinib_tosylate", "name": "RITLECITINIB TOSYLATE", "aliases": ["RITLECITINIB TOSYLATE", "Pf-06651600 tosylate", "Ritlecitinib tosilate", "Ritlecitinib toslate", "Ritlecitinib tosylate"], "external_ids": {"opentargets": "CHEMBL5314649", "disease_id": "EFO_0004208"}}
 {"id": 16, "kind": "target", "key": "jak3", "name": "JAK3", "aliases": ["JAK3", "Janus kinase 3"], "external_ids": {"ensembl": "ENSG00000105639", "opentargets": "ENSG00000105639", "disease_id": "EFO_0004208"}}
@@ -1361,7 +1361,7 @@
 {"id": 3009, "kind": "disease", "key": "mycosis_fungoides", "name": "Mycosis Fungoides", "aliases": ["Mycosis Fungoides"], "external_ids": {"mesh": "D009182"}}
 {"id": 3010, "kind": "target", "key": "ais1", "name": "AIS1", "aliases": ["AIS1"], "external_ids": {}}
 {"id": 3011, "kind": "target", "key": "aitd1", "name": "AITD1", "aliases": ["AITD1"], "external_ids": {}}
-{"id": 3012, "kind": "target", "key": "klrc1", "name": "KLRC1", "aliases": ["KLRC1"], "external_ids": {}}
+{"id": 3012, "kind": "target", "key": "klrc1", "name": "KLRC1", "aliases": ["KLRC1", "Klrc1"], "external_ids": {}}
 {"id": 3013, "kind": "target", "key": "klrd1", "name": "KLRD1", "aliases": ["KLRD1"], "external_ids": {}}
 {"id": 3014, "kind": "disease", "key": "hypopigmentation", "name": "Hypopigmentation", "aliases": ["Hypopigmentation"], "external_ids": {"mesh": "D017496"}}
 {"id": 3015, "kind": "target", "key": "klrc2", "name": "KLRC2", "aliases": ["KLRC2"], "external_ids": {}}
@@ -1729,7 +1729,7 @@
 {"id": 3377, "kind": "target", "key": "calm1", "name": "CALM1", "aliases": ["CALM1"], "external_ids": {}}
 {"id": 3378, "kind": "target", "key": "dnah8", "name": "DNAH8", "aliases": ["DNAH8"], "external_ids": {}}
 {"id": 3379, "kind": "drug", "key": "prednisolone", "name": "prednisolone", "aliases": ["Prednisolone", "prednisolone"], "external_ids": {"mesh": "D011239"}}
-{"id": 3380, "kind": "target", "key": "pcna", "name": "PCNA", "aliases": ["PCNA"], "external_ids": {}}
+{"id": 3380, "kind": "target", "key": "pcna", "name": "PCNA", "aliases": ["PCNA", "Pcna"], "external_ids": {}}
 {"id": 3381, "kind": "target", "key": "cdkn2a", "name": "CDKN2A", "aliases": ["CDKN2A"], "external_ids": {}}
 {"id": 3382, "kind": "biomarker", "key": "nylons", "name": "Nylons", "aliases": ["Nylons"], "external_ids": {"mesh": "D009757"}}
 {"id": 3383, "kind": "target", "key": "mc4r", "name": "MC4R", "aliases": ["MC4R"], "external_ids": {}}
@@ -1799,7 +1799,7 @@
 {"id": 3447, "kind": "biomarker", "key": "xanthine", "name": "Xanthine", "aliases": ["Xanthine"], "external_ids": {"mesh": "D019820"}}
 {"id": 3448, "kind": "disease", "key": "von_willebrand_diseases", "name": "von Willebrand Diseases", "aliases": ["von Willebrand Diseases"], "external_ids": {"mesh": "D014842"}}
 {"id": 3449, "kind": "target", "key": "vwf", "name": "VWF", "aliases": ["VWF"], "external_ids": {}}
-{"id": 3450, "kind": "target", "key": "hspa1b", "name": "HSPA1B", "aliases": ["HSPA1B"], "external_ids": {}}
+{"id": 3450, "kind": "target", "key": "hspa1b", "name": "HSPA1B", "aliases": ["HSPA1B", "Hspa1b"], "external_ids": {}}
 {"id": 3451, "kind": "target", "key": "csf3", "name": "CSF3", "aliases": ["CSF3"], "external_ids": {}}
 {"id": 3452, "kind": "drug", "key": "vitamin_d", "name": "vitamin D", "aliases": ["Vitamin D", "vitamin D"], "external_ids": {"mesh": "D014807"}}
 {"id": 3453, "kind": "disease", "key": "hyperparathyroidism_secondary", "name": "Hyperparathyroidism, Secondary", "aliases": ["Hyperparathyroidism, Secondary"], "external_ids": {"mesh": "D006962"}}
@@ -1880,7 +1880,7 @@
 {"id": 3528, "kind": "target", "key": "c4a", "name": "C4A", "aliases": ["C4A"], "external_ids": {}}
 {"id": 3529, "kind": "target", "key": "tnfrsf10b", "name": "TNFRSF10B", "aliases": ["TNFRSF10B"], "external_ids": {}}
 {"id": 3530, "kind": "target", "key": "plbd2", "name": "PLBD2", "aliases": ["PLBD2"], "external_ids": {}}
-{"id": 3531, "kind": "target", "key": "mdm2", "name": "MDM2", "aliases": ["MDM2"], "external_ids": {}}
+{"id": 3531, "kind": "target", "key": "mdm2", "name": "MDM2", "aliases": ["MDM2", "Mdm2"], "external_ids": {}}
 {"id": 3532, "kind": "biomarker", "key": "8_hydroxyguanine", "name": "8-hydroxyguanine", "aliases": ["8-hydroxyguanine"], "external_ids": {"mesh": "C024829"}}
 {"id": 3533, "kind": "target", "key": "nr1h3", "name": "NR1H3", "aliases": ["NR1H3"], "external_ids": {}}
 {"id": 3534, "kind": "target", "key": "ccl2", "name": "CCL2", "aliases": ["CCL2"], "external_ids": {}}
@@ -2008,7 +2008,7 @@
 {"id": 3656, "kind": "drug", "key": "butylated_hydroxytoluene", "name": "Butylated Hydroxytoluene", "aliases": ["Butylated Hydroxytoluene"], "external_ids": {"mesh": "D002084"}}
 {"id": 3657, "kind": "target", "key": "ren", "name": "REN", "aliases": ["REN"], "external_ids": {}}
 {"id": 3658, "kind": "biomarker", "key": "hemin", "name": "Hemin", "aliases": ["Hemin"], "external_ids": {"mesh": "D006427"}}
-{"id": 3659, "kind": "target", "key": "ets1", "name": "ETS1", "aliases": ["ETS1"], "external_ids": {}}
+{"id": 3659, "kind": "target", "key": "ets1", "name": "ETS1", "aliases": ["ETS1", "Ets1"], "external_ids": {}}
 {"id": 3660, "kind": "biomarker", "key": "pheomelanin", "name": "pheomelanin", "aliases": ["pheomelanin"], "external_ids": {"mesh": "C018362"}}
 {"id": 3661, "kind": "disease", "key": "pityriasis_rubra_pilaris", "name": "Pityriasis rubra pilaris", "aliases": ["Pityriasis Rubra Pilaris", "Pityriasis rubra pilaris"], "external_ids": {"mesh": "D010916"}}
 {"id": 3662, "kind": "drug", "key": "zinc_sulfate", "name": "zinc sulfate", "aliases": ["Zinc Sulfate", "zinc sulfate"], "external_ids": {"mesh": "D019287"}}
@@ -2302,7 +2302,7 @@
 {"id": 3950, "kind": "target", "key": "396425", "name": "396425", "aliases": ["396425"], "external_ids": {}}
 {"id": 3951, "kind": "target", "key": "prkdc", "name": "PRKDC", "aliases": ["PRKDC"], "external_ids": {}}
 {"id": 3952, "kind": "target", "key": "pparg", "name": "PPARG", "aliases": ["PPARG"], "external_ids": {}}
-{"id": 3953, "kind": "target", "key": "calca", "name": "CALCA", "aliases": ["CALCA"], "external_ids": {}}
+{"id": 3953, "kind": "target", "key": "calca", "name": "CALCA", "aliases": ["CALCA", "Calca"], "external_ids": {}}
 {"id": 3954, "kind": "drug", "key": "alpha_tocopherol", "name": "alpha-tocopherol", "aliases": ["alpha-Tocopherol", "alpha-tocopherol"], "external_ids": {"mesh": "D024502"}}
 {"id": 3955, "kind": "biomarker", "key": "scopoletin", "name": "Scopoletin", "aliases": ["Scopoletin"], "external_ids": {"mesh": "D012603"}}
 {"id": 3956, "kind": "target", "key": "cd19", "name": "CD19", "aliases": ["CD19"], "external_ids": {}}
@@ -2517,7 +2517,7 @@
 {"id": 4165, "kind": "disease", "key": "urologic_diseases", "name": "Urologic Diseases", "aliases": ["Urologic Diseases"], "external_ids": {"mesh": "D014570"}}
 {"id": 4166, "kind": "disease", "key": "paraparesis_spastic", "name": "Paraparesis, Spastic", "aliases": ["Paraparesis, Spastic"], "external_ids": {"mesh": "D020336"}}
 {"id": 4167, "kind": "biomarker", "key": "toceranib_phosphate", "name": "toceranib phosphate", "aliases": ["toceranib phosphate"], "external_ids": {"mesh": "C464577"}}
-{"id": 4168, "kind": "target", "key": "nup62", "name": "NUP62", "aliases": ["NUP62"], "external_ids": {}}
+{"id": 4168, "kind": "target", "key": "nup62", "name": "NUP62", "aliases": ["NUP62", "Nup62"], "external_ids": {}}
 {"id": 4169, "kind": "drug", "key": "atezolizumab", "name": "atezolizumab", "aliases": ["atezolizumab"], "external_ids": {"mesh": "C000594389"}}
 {"id": 4170, "kind": "disease", "key": "sarcoidosis", "name": "Sarcoidosis", "aliases": ["Sarcoidosis"], "external_ids": {"mesh": "D012507"}}
 {"id": 4171, "kind": "target", "key": "lrba", "name": "LRBA", "aliases": ["LRBA"], "external_ids": {}}
@@ -2566,7 +2566,7 @@
 {"id": 4214, "kind": "disease", "key": "adenocarcinoma_of_lung", "name": "Adenocarcinoma of Lung", "aliases": ["Adenocarcinoma of Lung"], "external_ids": {"mesh": "D000077192"}}
 {"id": 4215, "kind": "disease", "key": "pleural_effusion", "name": "Pleural effusion", "aliases": ["Pleural Effusion", "Pleural effusion"], "external_ids": {"mesh": "D010996"}}
 {"id": 4216, "kind": "disease", "key": "hodgkin_disease", "name": "Hodgkin Disease", "aliases": ["Hodgkin Disease"], "external_ids": {"mesh": "D006689"}}
-{"id": 4217, "kind": "target", "key": "casp8", "name": "CASP8", "aliases": ["CASP8"], "external_ids": {}}
+{"id": 4217, "kind": "target", "key": "casp8", "name": "CASP8", "aliases": ["CASP8", "Casp8"], "external_ids": {}}
 {"id": 4218, "kind": "disease", "key": "neuroblastoma", "name": "Neuroblastoma", "aliases": ["Neuroblastoma"], "external_ids": {"mesh": "D009447"}}
 {"id": 4219, "kind": "disease", "key": "diabetic_ketoacidosis", "name": "Diabetic ketoacidosis", "aliases": ["Diabetic Ketoacidosis", "Diabetic ketoacidosis"], "external_ids": {"mesh": "D016883"}}
 {"id": 4220, "kind": "disease", "key": "epidermolysis_bullosa", "name": "Epidermolysis Bullosa", "aliases": ["Epidermolysis Bullosa"], "external_ids": {"mesh": "D004820"}}
@@ -2618,7 +2618,7 @@
 {"id": 4266, "kind": "target", "key": "nos1", "name": "NOS1", "aliases": ["NOS1"], "external_ids": {}}
 {"id": 4267, "kind": "target", "key": "apoe", "name": "APOE", "aliases": ["APOE"], "external_ids": {}}
 {"id": 4268, "kind": "target", "key": "apol1", "name": "APOL1", "aliases": ["APOL1"], "external_ids": {}}
-{"id": 4269, "kind": "target", "key": "adipoq", "name": "ADIPOQ", "aliases": ["ADIPOQ"], "external_ids": {}}
+{"id": 4269, "kind": "target", "key": "adipoq", "name": "ADIPOQ", "aliases": ["ADIPOQ", "Adipoq"], "external_ids": {}}
 {"id": 4270, "kind": "target", "key": "lep", "name": "LEP", "aliases": ["LEP"], "external_ids": {}}
 {"id": 4271, "kind": "drug", "key": "dupilumab", "name": "dupilumab", "aliases": ["dupilumab"], "external_ids": {"mesh": "C582203"}}
 {"id": 4272, "kind": "drug", "key": "aripiprazole", "name": "Aripiprazole", "aliases": ["Aripiprazole"], "external_ids": {"mesh": "D000068180"}}
@@ -2747,7 +2747,7 @@
 {"id": 4395, "kind": "disease", "key": "dysplastic_nevus_syndrome", "name": "Dysplastic Nevus Syndrome", "aliases": ["Dysplastic Nevus Syndrome"], "external_ids": {"mesh": "D004416"}}
 {"id": 4396, "kind": "drug", "key": "honokiol", "name": "honokiol", "aliases": ["honokiol"], "external_ids": {"mesh": "C005499"}}
 {"id": 4397, "kind": "target", "key": "opa1", "name": "OPA1", "aliases": ["OPA1"], "external_ids": {}}
-{"id": 4398, "kind": "target", "key": "sirt3", "name": "SIRT3", "aliases": ["SIRT3"], "external_ids": {}}
+{"id": 4398, "kind": "target", "key": "sirt3", "name": "SIRT3", "aliases": ["SIRT3", "Sirt3"], "external_ids": {}}
 {"id": 4399, "kind": "target", "key": "map2k1", "name": "Map2k1", "aliases": ["Map2k1", "MAP2K1"], "external_ids": {}}
 {"id": 4400, "kind": "target", "key": "map3k14", "name": "Map3k14", "aliases": ["Map3k14"], "external_ids": {}}
 {"id": 4401, "kind": "target", "key": "akt2", "name": "AKT2", "aliases": ["AKT2"], "external_ids": {}}
@@ -2909,7 +2909,7 @@
 {"id": 4557, "kind": "target", "key": "pdpk1", "name": "PDPK1", "aliases": ["PDPK1"], "external_ids": {}}
 {"id": 4558, "kind": "target", "key": "cactin", "name": "CACTIN", "aliases": ["CACTIN"], "external_ids": {}}
 {"id": 4559, "kind": "target", "key": "dctn1", "name": "DCTN1", "aliases": ["DCTN1"], "external_ids": {}}
-{"id": 4560, "kind": "target", "key": "gpr143", "name": "GPR143", "aliases": ["GPR143"], "external_ids": {}}
+{"id": 4560, "kind": "target", "key": "gpr143", "name": "GPR143", "aliases": ["GPR143", "Gpr143"], "external_ids": {}}
 {"id": 4561, "kind": "biomarker", "key": "bakuchicin", "name": "bakuchicin", "aliases": ["bakuchicin"], "external_ids": {"mesh": "C459213"}}
 {"id": 4562, "kind": "target", "key": "il31", "name": "IL31", "aliases": ["IL31"], "external_ids": {}}
 {"id": 4563, "kind": "target", "key": "ighv1_9", "name": "Ighv1-9", "aliases": ["Ighv1-9"], "external_ids": {}}
@@ -2918,7 +2918,7 @@
 {"id": 4566, "kind": "target", "key": "rhoj", "name": "RHOJ", "aliases": ["RHOJ"], "external_ids": {}}
 {"id": 4567, "kind": "target", "key": "tnfrsf12a", "name": "TNFRSF12A", "aliases": ["TNFRSF12A"], "external_ids": {}}
 {"id": 4568, "kind": "target", "key": "tnfsf12", "name": "TNFSF12", "aliases": ["TNFSF12"], "external_ids": {}}
-{"id": 4569, "kind": "target", "key": "tfrc", "name": "TFRC", "aliases": ["TFRC"], "external_ids": {}}
+{"id": 4569, "kind": "target", "key": "tfrc", "name": "TFRC", "aliases": ["TFRC", "Tfrc"], "external_ids": {}}
 {"id": 4570, "kind": "disease", "key": "lymphohistiocytosis_hemophagocytic", "name": "Lymphohistiocytosis, Hemophagocytic", "aliases": ["Lymphohistiocytosis, Hemophagocytic"], "external_ids": {"mesh": "D051359"}}
 {"id": 4571, "kind": "target", "key": "cyp21a1", "name": "Cyp21a1", "aliases": ["Cyp21a1"], "external_ids": {}}
 {"id": 4572, "kind": "target", "key": "trpa1", "name": "TRPA1", "aliases": ["TRPA1"], "external_ids": {}}
@@ -3240,7 +3240,7 @@
 {"id": 4888, "kind": "biomarker", "key": "5_hydroxy_6_methoxyindole", "name": "5-hydroxy-6-methoxyindole", "aliases": ["5-hydroxy-6-methoxyindole"], "external_ids": {"mesh": "C038282"}}
 {"id": 4889, "kind": "biomarker", "key": "5_hydroxy_6_methoxy_2_indolylcarboxylic_acid", "name": "5-hydroxy-6-methoxy-2-indolylcarboxylic acid", "aliases": ["5-hydroxy-6-methoxy-2-indolylcarboxylic acid"], "external_ids": {"mesh": "C017407"}}
 {"id": 4890, "kind": "disease", "key": "abdominal_pain", "name": "Abdominal pain", "aliases": ["Abdominal Pain", "Abdominal pain"], "external_ids": {"mesh": "D015746"}}
-{"id": 4891, "kind": "target", "key": "csf1r", "name": "CSF1R", "aliases": ["CSF1R"], "external_ids": {}}
+{"id": 4891, "kind": "target", "key": "csf1r", "name": "CSF1R", "aliases": ["CSF1R", "Csf1r"], "external_ids": {}}
 {"id": 4892, "kind": "target", "key": "trib1", "name": "TRIB1", "aliases": ["TRIB1"], "external_ids": {}}
 {"id": 4893, "kind": "biomarker", "key": "4_phenylbutylamine", "name": "4-phenylbutylamine", "aliases": ["4-phenylbutylamine"], "external_ids": {"mesh": "C121358"}}
 {"id": 4894, "kind": "biomarker", "key": "ginsenoside_rb1", "name": "ginsenoside Rb1", "aliases": ["ginsenoside Rb1"], "external_ids": {"mesh": "C442759"}}
@@ -3452,7 +3452,7 @@
 {"id": 5100, "kind": "biomarker", "key": "genkwanin", "name": "genkwanin", "aliases": ["genkwanin"], "external_ids": {"mesh": "C014568"}}
 {"id": 5101, "kind": "biomarker", "key": "calycosin_7_o_beta_d_glucoside", "name": "calycosin-7-O-beta-D-glucoside", "aliases": ["calycosin-7-O-beta-D-glucoside"], "external_ids": {"mesh": "C526426"}}
 {"id": 5102, "kind": "biomarker", "key": "imvp_16_protocol", "name": "IMVP-16 protocol", "aliases": ["IMVP-16 protocol"], "external_ids": {"mesh": "C035713"}}
-{"id": 5103, "kind": "target", "key": "tnfsf9", "name": "TNFSF9", "aliases": ["TNFSF9"], "external_ids": {}}
+{"id": 5103, "kind": "target", "key": "tnfsf9", "name": "TNFSF9", "aliases": ["TNFSF9", "Tnfsf9"], "external_ids": {}}
 {"id": 5104, "kind": "target", "key": "rab27a", "name": "RAB27A", "aliases": ["RAB27A"], "external_ids": {}}
 {"id": 5105, "kind": "drug", "key": "rosiglitazone", "name": "Rosiglitazone", "aliases": ["Rosiglitazone"], "external_ids": {"mesh": "D000077154"}}
 {"id": 5106, "kind": "target", "key": "tyrp1a", "name": "tyrp1a", "aliases": ["tyrp1a"], "external_ids": {}}
@@ -4089,8 +4089,8 @@
 {"id": 5737, "kind": "target", "key": "spi1", "name": "SPI1", "aliases": ["SPI1"], "external_ids": {}}
 {"id": 5738, "kind": "drug", "key": "artesunate", "name": "Artesunate", "aliases": ["Artesunate"], "external_ids": {"mesh": "D000077332"}}
 {"id": 5739, "kind": "target", "key": "gpr17", "name": "Gpr17", "aliases": ["Gpr17"], "external_ids": {}}
-{"id": 5740, "kind": "target", "key": "lck", "name": "LCK", "aliases": ["LCK"], "external_ids": {}}
-{"id": 5741, "kind": "target", "key": "fyn", "name": "FYN", "aliases": ["FYN"], "external_ids": {}}
+{"id": 5740, "kind": "target", "key": "lck", "name": "LCK", "aliases": ["LCK", "Lck"], "external_ids": {}}
+{"id": 5741, "kind": "target", "key": "fyn", "name": "FYN", "aliases": ["FYN", "Fyn"], "external_ids": {}}
 {"id": 5742, "kind": "target", "key": "nfkbia", "name": "NFKBIA", "aliases": ["NFKBIA"], "external_ids": {}}
 {"id": 5743, "kind": "target", "key": "spic", "name": "Spic", "aliases": ["Spic"], "external_ids": {}}
 {"id": 5744, "kind": "target", "key": "atg13", "name": "ATG13", "aliases": ["ATG13"], "external_ids": {}}
@@ -4116,7 +4116,7 @@
 {"id": 5764, "kind": "biomarker", "key": "itaconic_acid", "name": "itaconic acid", "aliases": ["itaconic acid"], "external_ids": {"mesh": "C005229"}}
 {"id": 5765, "kind": "target", "key": "acod1", "name": "ACOD1", "aliases": ["ACOD1"], "external_ids": {}}
 {"id": 5766, "kind": "biomarker", "key": "n_n_2_2_hexa_2_4_diyne_1_6_diylbis_oxy_bis_2_3_dihydro_1h_indene_2_1_diyl_bis_1_2_cyclohexyl_2_2_methylamino_propanamido", "name": "N,N'-(2,2'-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-(2-cyclohexyl-2-(2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide)", "aliases": ["N,N'-(2,2'-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-(2-cyclohexyl-2-(2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide)"], "external_ids": {"mesh": "C586719"}}
-{"id": 5767, "kind": "target", "key": "csf1", "name": "CSF1", "aliases": ["CSF1"], "external_ids": {}}
+{"id": 5767, "kind": "target", "key": "csf1", "name": "CSF1", "aliases": ["CSF1", "Csf1"], "external_ids": {}}
 {"id": 5768, "kind": "disease", "key": "cerebral_hemorrhage", "name": "Cerebral Hemorrhage", "aliases": ["Cerebral Hemorrhage"], "external_ids": {"mesh": "D002543"}}
 {"id": 5769, "kind": "drug", "key": "sulfanilamide", "name": "Sulfanilamide", "aliases": ["Sulfanilamide"], "external_ids": {"mesh": "D000077145"}}
 {"id": 5770, "kind": "drug", "key": "oxazolone", "name": "Oxazolone", "aliases": ["Oxazolone"], "external_ids": {"mesh": "D010081"}}
@@ -4147,12 +4147,12 @@
 {"id": 5795, "kind": "target", "key": "herpud1", "name": "HERPUD1", "aliases": ["HERPUD1"], "external_ids": {}}
 {"id": 5796, "kind": "biomarker", "key": "vtx_2337", "name": "VTX-2337", "aliases": ["VTX-2337"], "external_ids": {"mesh": "C573973"}}
 {"id": 5797, "kind": "drug", "key": "cobicistat", "name": "Cobicistat", "aliases": ["Cobicistat"], "external_ids": {"mesh": "D000069547"}}
-{"id": 5798, "kind": "target", "key": "il10ra", "name": "IL10RA", "aliases": ["IL10RA"], "external_ids": {}}
+{"id": 5798, "kind": "target", "key": "il10ra", "name": "IL10RA", "aliases": ["IL10RA", "Il10ra"], "external_ids": {}}
 {"id": 5799, "kind": "target", "key": "gas6", "name": "Gas6", "aliases": ["Gas6"], "external_ids": {}}
 {"id": 5800, "kind": "target", "key": "gan", "name": "GAN", "aliases": ["GAN"], "external_ids": {}}
 {"id": 5801, "kind": "biomarker", "key": "aluminum_oxide", "name": "Aluminum Oxide", "aliases": ["Aluminum Oxide"], "external_ids": {"mesh": "D000537"}}
 {"id": 5802, "kind": "target", "key": "fabp7", "name": "Fabp7", "aliases": ["Fabp7"], "external_ids": {}}
-{"id": 5803, "kind": "target", "key": "abca1", "name": "ABCA1", "aliases": ["ABCA1"], "external_ids": {}}
+{"id": 5803, "kind": "target", "key": "abca1", "name": "ABCA1", "aliases": ["ABCA1", "Abca1"], "external_ids": {}}
 {"id": 5804, "kind": "biomarker", "key": "t_0070907", "name": "T 0070907", "aliases": ["T 0070907"], "external_ids": {"mesh": "C458508"}}
 {"id": 5805, "kind": "disease", "key": "thyroid_cancer_papillary", "name": "Thyroid Cancer, Papillary", "aliases": ["Thyroid Cancer, Papillary"], "external_ids": {"mesh": "D000077273"}}
 {"id": 5806, "kind": "disease", "key": "neuralgia_postherpetic", "name": "Neuralgia, Postherpetic", "aliases": ["Neuralgia, Postherpetic"], "external_ids": {"mesh": "D051474"}}
@@ -4233,13 +4233,13 @@
 {"id": 5881, "kind": "target", "key": "icam4_as1", "name": "ICAM4-AS1", "aliases": ["ICAM4-AS1"], "external_ids": {}}
 {"id": 5882, "kind": "target", "key": "cd96", "name": "CD96", "aliases": ["CD96"], "external_ids": {}}
 {"id": 5883, "kind": "target", "key": "cd70", "name": "CD70", "aliases": ["CD70"], "external_ids": {}}
-{"id": 5884, "kind": "target", "key": "krt25", "name": "KRT25", "aliases": ["KRT25"], "external_ids": {}}
+{"id": 5884, "kind": "target", "key": "krt25", "name": "KRT25", "aliases": ["KRT25", "Krt25"], "external_ids": {}}
 {"id": 5885, "kind": "target", "key": "krt27", "name": "Krt27", "aliases": ["Krt27"], "external_ids": {}}
 {"id": 5886, "kind": "target", "key": "junb", "name": "JUNB", "aliases": ["JUNB"], "external_ids": {}}
 {"id": 5887, "kind": "target", "key": "atp6v0d2", "name": "Atp6v0d2", "aliases": ["Atp6v0d2"], "external_ids": {}}
 {"id": 5888, "kind": "target", "key": "atp6v1g3", "name": "Atp6v1g3", "aliases": ["Atp6v1g3"], "external_ids": {}}
-{"id": 5889, "kind": "target", "key": "ifit1", "name": "IFIT1", "aliases": ["IFIT1"], "external_ids": {}}
-{"id": 5890, "kind": "target", "key": "ifit3", "name": "IFIT3", "aliases": ["IFIT3"], "external_ids": {}}
+{"id": 5889, "kind": "target", "key": "ifit1", "name": "IFIT1", "aliases": ["IFIT1", "Ifit1"], "external_ids": {}}
+{"id": 5890, "kind": "target", "key": "ifit3", "name": "IFIT3", "aliases": ["IFIT3", "Ifit3"], "external_ids": {}}
 {"id": 5891, "kind": "target", "key": "pdc", "name": "PDC", "aliases": ["PDC"], "external_ids": {}}
 {"id": 5892, "kind": "target", "key": "prame", "name": "PRAME", "aliases": ["PRAME"], "external_ids": {}}
 {"id": 5893, "kind": "disease", "key": "down_syndrome", "name": "Down Syndrome", "aliases": ["Down Syndrome"], "external_ids": {"mesh": "D004314"}}
@@ -16120,3 +16120,16 @@
 {"id": 17988, "kind": "disease", "key": "laryngeal_injury", "name": "LARYNGEAL INJURY", "aliases": ["LARYNGEAL INJURY"], "external_ids": {}}
 {"id": 17989, "kind": "disease", "key": "carotid_artery_dissection", "name": "CAROTID ARTERY DISSECTION", "aliases": ["CAROTID ARTERY DISSECTION"], "external_ids": {}}
 {"id": 17990, "kind": "disease", "key": "hallucination_auditory", "name": "HALLUCINATION, AUDITORY", "aliases": ["HALLUCINATION, AUDITORY"], "external_ids": {}}
+{"id": 17991, "kind": "pathway", "key": "ifn_gamma_signaling_pathway", "name": "IFN-gamma Signaling Pathway", "aliases": ["IFN-gamma Signaling Pathway"], "external_ids": {"go": "GO:0060333", "reactome": "R-HSA-877300"}}
+{"id": 17992, "kind": "pathway", "key": "jak_stat_signaling_cascade", "name": "JAK-STAT Signaling Cascade", "aliases": ["JAK-STAT Signaling Cascade"], "external_ids": {"go": "GO:0007259", "reactome": "R-HSA-909733"}}
+{"id": 17993, "kind": "pathway", "key": "melanocyte_differentiation_and_pigmentation", "name": "Melanocyte Differentiation and Pigmentation", "aliases": ["Melanocyte Differentiation and Pigmentation"], "external_ids": {"go": "GO:0043473", "reactome": "R-HSA-5579029"}}
+{"id": 17994, "kind": "pathway", "key": "wnt_beta_catenin_stem_cell_signaling", "name": "Wnt/Beta-Catenin Stem-Cell Signaling", "aliases": ["Wnt/Beta-Catenin Stem-Cell Signaling"], "external_ids": {"go": "GO:0016055", "reactome": "R-HSA-195721"}}
+{"id": 17995, "kind": "pathway", "key": "tissue_resident_memory_t_cell_activation", "name": "Tissue-Resident Memory T-Cell Activation", "aliases": ["Tissue-Resident Memory T-Cell Activation"], "external_ids": {"go": "GO:0042110", "mesh": "D000085442"}}
+{"id": 17996, "kind": "pathway", "key": "cgas_sting_cytosolic_dna_sensing_pathway", "name": "cGAS-STING Cytosolic DNA Sensing Pathway", "aliases": ["cGAS-STING Cytosolic DNA Sensing Pathway"], "external_ids": {"go": "GO:0060337", "reactome": "R-HSA-9615017"}}
+{"id": 17997, "kind": "pathway", "key": "cellular_response_to_oxidative_stress", "name": "Cellular Response to Oxidative Stress", "aliases": ["Cellular Response to Oxidative Stress"], "external_ids": {"go": "GO:0034599", "reactome": "R-HSA-3299685"}}
+{"id": 17998, "kind": "pathway", "key": "phosphodiesterase_pde4_and_camp_barrier_axis", "name": "Phosphodiesterase (PDE4) and cAMP Barrier Axis", "aliases": ["Phosphodiesterase (PDE4) and cAMP Barrier Axis"], "external_ids": {"reactome": "R-HSA-111997"}}
+{"id": 17999, "kind": "pathway", "key": "prostaglandin_fp_receptor_signaling", "name": "Prostaglandin FP Receptor Signaling", "aliases": ["Prostaglandin FP Receptor Signaling"], "external_ids": {"reactome": "R-HSA-2142753"}}
+{"id": 18000, "kind": "cell_type", "key": "epidermal_melanocyte", "name": "Epidermal Melanocyte", "aliases": ["Epidermal Melanocyte"], "external_ids": {"cell_ontology": "CL:0000148", "mesh": "D008544"}}
+{"id": 18001, "kind": "cell_type", "key": "hair_follicle_melanocyte_stem_cell_mcsc", "name": "Hair Follicle Melanocyte Stem Cell (McSC)", "aliases": ["Hair Follicle Melanocyte Stem Cell (McSC)"], "external_ids": {"cell_ontology": "CL:0002092"}}
+{"id": 18002, "kind": "cell_type", "key": "cd8_tissue_resident_memory_t_cell_trm", "name": "CD8+ Tissue-Resident Memory T Cell (TRM)", "aliases": ["CD8+ Tissue-Resident Memory T Cell (TRM)"], "external_ids": {"cell_ontology": "CL:0000909", "mesh": "D000085442"}}
+{"id": 18003, "kind": "cell_type", "key": "basal_keratinocyte", "name": "Basal Keratinocyte", "aliases": ["Basal Keratinocyte"], "external_ids": {"cell_ontology": "CL:0002187"}}

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