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+# Identical source PDFs
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We identified eligible infants from operating room schedules or at preadmission","text_display":" language. We identified eligible infants from operating room schedules or at preadmission","confidence":1,"confidence_rate":1},{"cnt":[[245,2194],[1656,2194],[1656,2241],[245,2241]],"region":{"top_left_x":244,"top_left_y":2193,"width":1413,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2eb917b4a15341a9b3810dc0235ba497","type":"text","conversion_output":true,"text":"clinics and recruited in the clinic or in the preadmission areas of the operating floor.","text_display":" clinics and recruited in the clinic or in the preadmission areas of the operating floor.","confidence":1,"confidence_rate":1},{"cnt":[[245,2286],[737,2286],[737,2335],[245,2335]],"region":{"top_left_x":244,"top_left_y":2285,"width":493,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"329ff93c388c423c9b818bb4b6f37bc0","type":"text","conversion_output":true,"text":"Randomisation and masking","text_display":"\n\nRandomisation and masking","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"5d26818e-2d50-4a6d-8d84-6ff93172aad9-2","page":2,"lines":[{"cnt":[[245,269],[1835,269],[1835,320],[245,320]],"region":{"top_left_x":244,"top_left_y":268,"width":1591,"height":53},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe6ee7c553e74a3e996f230beb7ccc75","type":"text","conversion_output":true,"text":"Infants were randomly assigned ( \\(1: 1\\) ) to receive either general anaesthesia or awake-regional","text_display":"\n\nInfants were randomly assigned ( \\(1: 1\\) ) to receive either general anaesthesia or awake-regional","confidence":0.956228494644165,"confidence_rate":0.9995612885820555},{"cnt":[[245,329],[1876,329],[1876,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1632,"height":53},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83dc1e8af0d54396b800dfd3aaac5045","type":"text","conversion_output":true,"text":"anaesthesia using a \\(24- h\\) web-based randomisation service managed by the Data Management","text_display":" anaesthesia using a \\(24- h\\) web-based randomisation service managed by the Data Management","confidence":0.9560424741357565,"confidence_rate":0.9995414017403286},{"cnt":[[245,391],[1665,391],[1665,445],[245,445]],"region":{"top_left_x":244,"top_left_y":391,"width":1422,"height":54},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d06b5f998d914f96ac00672087015b66","type":"text","conversion_output":true,"text":"and Analysis Centre, Department of Public Health, University of Adelaide, Australia.","text_display":" and Analysis Centre, Department of Public Health, University of Adelaide, Australia.","confidence":1,"confidence_rate":1},{"cnt":[[245,455],[1818,455],[1818,505],[245,505]],"region":{"top_left_x":244,"top_left_y":455,"width":1574,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95e91cfe0c324feba88496d2e47bec7e","type":"text","conversion_output":true,"text":"Randomisation was done in blocks of two or four in a computer-generated random-allocation","text_display":" Randomisation was done in blocks of two or four in a computer-generated random-allocation","confidence":1,"confidence_rate":1},{"cnt":[[245,518],[1876,518],[1876,569],[245,569]],"region":{"top_left_x":244,"top_left_y":517,"width":1632,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0852571d8037464db5efc07466012409","type":"text","conversion_output":true,"text":"sequence, with stratification by site and by gestational age at birth ( 26 weeks to 29 weeks and 6","text_display":" sequence, with stratification by site and by gestational age at birth ( 26 weeks to 29 weeks and 6","confidence":0.9985356330871582,"confidence_rate":0.9999864312018168},{"cnt":[[245,580],[1837,580],[1837,629],[245,629]],"region":{"top_left_x":244,"top_left_y":580,"width":1593,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86da3bbb3469421480e0b8b329d6db03","type":"text","conversion_output":true,"text":"days, 30 weeks to 36 weeks and 6 days, and 37 weeks or more). The anaesthetist was aware","text_display":" days, 30 weeks to 36 weeks and 6 days, and 37 weeks or more). The anaesthetist was aware","confidence":0.9960954189300537,"confidence_rate":0.9999627414193785},{"cnt":[[245,645],[1794,645],[1794,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1550,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"633b4b0799f84870a4ba2fc5a61ffe93","type":"text","conversion_output":true,"text":"of group allocation, but individuals who administered the neurodevelopmental assessments","text_display":" of group allocation, but individuals who administered the neurodevelopmental assessments","confidence":1,"confidence_rate":1},{"cnt":[[245,705],[1790,705],[1790,754],[245,754]],"region":{"top_left_x":244,"top_left_y":704,"width":1546,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca4045a27ede48ecb9449565ad2492eb","type":"text","conversion_output":true,"text":"were not. Parents who asked about their infant's group allocation were informed and told to","text_display":" were not. Parents who asked about their infant's group allocation were informed and told to","confidence":1,"confidence_rate":1},{"cnt":[[245,769],[1725,769],[1725,819],[245,819]],"region":{"top_left_x":244,"top_left_y":769,"width":1482,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99121835cd76452d955445097b0de1b3","type":"text","conversion_output":true,"text":"mask this information from assessors. After assessments were completed, parents and","text_display":" mask this information from assessors. After assessments were completed, parents and","confidence":1,"confidence_rate":1},{"cnt":[[245,829],[1285,829],[1285,881],[245,881]],"region":{"top_left_x":244,"top_left_y":829,"width":1041,"height":52},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f96b81083af14532a2ff14b68da0524a","type":"text","conversion_output":true,"text":"assessors were asked if they were aware of group allocation.","text_display":" assessors were asked if they were aware of group allocation.","confidence":1,"confidence_rate":1},{"cnt":[[241,920],[455,920],[455,973],[241,973]],"region":{"top_left_x":240,"top_left_y":919,"width":216,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b85de132a7a47d18f2fdb517527ce5a","type":"section_header","conversion_output":false,"children_ids":["5118ec1a61b347fe851891a5903f53a3"],"text":"","text_display":""},{"cnt":[[245,924],[449,924],[449,969],[245,969]],"region":{"top_left_x":244,"top_left_y":923,"width":206,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5118ec1a61b347fe851891a5903f53a3","type":"text","conversion_output":true,"parent_id":"4b85de132a7a47d18f2fdb517527ce5a","text":"Procedures","text_display":"\n\n\\section*{Procedures}","confidence":1,"confidence_rate":1},{"cnt":[[245,1036],[1669,1036],[1669,1085],[245,1085]],"region":{"top_left_x":244,"top_left_y":1035,"width":1426,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"494beaf662894696b02b38178a6f8541","type":"text","conversion_output":true,"text":"The awake-regional group received a spinal, caudal, or combined caudal and spinal","text_display":"\n\nThe awake-regional group received a spinal, caudal, or combined caudal and spinal","confidence":1,"confidence_rate":1},{"cnt":[[245,1096],[1865,1096],[1865,1147],[245,1147]],"region":{"top_left_x":244,"top_left_y":1095,"width":1621,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88fc3ae8bcb44aafbf553e34c431e0dc","type":"text","conversion_output":true,"text":"anaesthetic, according to institutional preferences. Bupivacaine or levobupivacaine at a dose of","text_display":" anaesthetic, according to institutional preferences. Bupivacaine or levobupivacaine at a dose of","confidence":1,"confidence_rate":1},{"cnt":[[245,1156],[1815,1156],[1815,1210],[245,1210]],"region":{"top_left_x":244,"top_left_y":1155,"width":1572,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3feb3852239149c8b83202bc556b053a","type":"text","conversion_output":true,"text":"\\(0 \\cdot 75-1 mg / kg\\) was administered for spinal anaesthesia. Caudal anaesthesia was with \\(0 \\cdot 25 \\%\\)","text_display":" \\(0 \\cdot 75-1 mg / kg\\) was administered for spinal anaesthesia. Caudal anaesthesia was with \\(0 \\cdot 25 \\%\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[1850,1220],[1850,1274],[245,1274]],"region":{"top_left_x":244,"top_left_y":1220,"width":1606,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cf9d018ac4949988c2aa2ad0d39688d","type":"text","conversion_output":true,"text":"bupivacaine or levobupivacaine up to a total dose of \\(2.5 mg / kg\\). In the USA, several patients in","text_display":" bupivacaine or levobupivacaine up to a total dose of \\(2.5 mg / kg\\). In the USA, several patients in","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[243,1285],[1790,1285],[1790,1334],[243,1334]],"region":{"top_left_x":242,"top_left_y":1284,"width":1548,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a02c49bab25c47aaa11bc05199074a16","type":"text","conversion_output":true,"text":"whom it was known that the surgery would take longer than 1 h were also administered \\(3 \\%\\)","text_display":" whom it was known that the surgery would take longer than 1 h were also administered \\(3 \\%\\)","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[245,1347],[1852,1347],[1852,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1347,"width":1608,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e3febceebf64c81aad05907eed7e4c0","type":"text","conversion_output":true,"text":"chloroprocaine via a caudal catheter (loading bolus of \\(3 \\%\\) chloroprocaine \\(1 mL / kg\\) over several","text_display":" chloroprocaine via a caudal catheter (loading bolus of \\(3 \\%\\) chloroprocaine \\(1 mL / kg\\) over several","confidence":0.9990234375,"confidence_rate":0.9999910363736797},{"cnt":[[245,1409],[1828,1409],[1828,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1409,"width":1585,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1998b7b3c04449dc9be1f62dd4243a26","type":"text","conversion_output":true,"text":"minutes and then an infusion at \\(1-2 mL / kg\\) per h). Additional ilioinguinal and field blocks were","text_display":" minutes and then an infusion at \\(1-2 mL / kg\\) per h). Additional ilioinguinal and field blocks were","confidence":0.57763671875,"confidence_rate":0.9949313141559091},{"cnt":[[245,1474],[1865,1474],[1865,1523],[245,1523]],"region":{"top_left_x":244,"top_left_y":1473,"width":1621,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5fd60b2c9de4680858e0133ff9524b3","type":"text","conversion_output":true,"text":"used according to surgical preference. Oral sucrose was given if the child was unsettled, but no","text_display":" used according to surgical preference. Oral sucrose was given if the child was unsettled, but no","confidence":1,"confidence_rate":1},{"cnt":[[245,1534],[1766,1534],[1766,1583],[245,1583]],"region":{"top_left_x":244,"top_left_y":1533,"width":1523,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d85fc9015064965853ff250f2c37ddf","type":"text","conversion_output":true,"text":"other pharmacological sedation was permitted. Infants who showed agitation that was not","text_display":" other pharmacological sedation was permitted. Infants who showed agitation that was not","confidence":1,"confidence_rate":1},{"cnt":[[245,1598],[1798,1598],[1798,1648],[245,1648]],"region":{"top_left_x":244,"top_left_y":1598,"width":1555,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b22314781b324a1ca7fcd375cd08ecd0","type":"text","conversion_output":true,"text":"resolved by oral sucrose, or in whom the awake-regional anaesthetic was inadequate, were","text_display":" resolved by oral sucrose, or in whom the awake-regional anaesthetic was inadequate, were","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[1850,1659],[1850,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1658,"width":1606,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15d13e3c76044417a8e82910d4cd16c8","type":"text","conversion_output":true,"text":"treated with sevoflurane. The administration of sevoflurane, nitrous oxide, or any other general","text_display":" treated with sevoflurane. The administration of sevoflurane, nitrous oxide, or any other general","confidence":1,"confidence_rate":1},{"cnt":[[245,1723],[1283,1723],[1283,1772],[245,1772]],"region":{"top_left_x":244,"top_left_y":1723,"width":1039,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b347f94fedcb424c9c1afc3cf2f82bc4","type":"text","conversion_output":true,"text":"anaesthetic in this group was considered a protocol violation.","text_display":" anaesthetic in this group was considered a protocol violation.","confidence":1,"confidence_rate":1},{"cnt":[[245,1826],[1858,1826],[1858,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1826,"width":1615,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22a6c9f2b52f432aadaca6fa728c2321","type":"text","conversion_output":true,"text":"The general anaesthesia group received sevoflurane for induction and maintenance in a mix of","text_display":"\n\nThe general anaesthesia group received sevoflurane for induction and maintenance in a mix of","confidence":1,"confidence_rate":1},{"cnt":[[245,1886],[1880,1886],[1880,1940],[245,1940]],"region":{"top_left_x":244,"top_left_y":1886,"width":1636,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54e7ebd0e3a5489dabe666fdfa6e2211","type":"text","conversion_output":true,"text":"air and oxygen. The concentration of sevoflurane, choice of airway device, ventilation technique,","text_display":" air and oxygen. The concentration of sevoflurane, choice of airway device, ventilation technique,","confidence":1,"confidence_rate":1},{"cnt":[[245,1951],[1760,1951],[1760,2000],[245,2000]],"region":{"top_left_x":244,"top_left_y":1950,"width":1516,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f825677bb09e4be88b9ea02a59375e00","type":"text","conversion_output":true,"text":"and use of neuromuscular blocking agents were left to the preference of the anaesthetist.","text_display":" and use of neuromuscular blocking agents were left to the preference of the anaesthetist.","confidence":1,"confidence_rate":1},{"cnt":[[245,2011],[1639,2011],[1639,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2010,"width":1396,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d619de542e304459bd84212f8e798f89","type":"text","conversion_output":true,"text":"Supplemental opioids and nitrous oxide were not allowed, but caudal, ilioinguinal-","text_display":" Supplemental opioids and nitrous oxide were not allowed, but caudal, ilioinguinal","confidence":1,"confidence_rate":1},{"cnt":[[245,2075],[1727,2075],[1727,2127],[245,2127]],"region":{"top_left_x":244,"top_left_y":2075,"width":1484,"height":52},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7fec47133c7f496e817931be9bc67f87","type":"text","conversion_output":true,"text":"iliohypogastric, or field blocks with bupivacaine were permitted to provide postoperative","text_display":"iliohypogastric, or field blocks with bupivacaine were permitted to provide postoperative","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[428,2140],[428,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2139,"width":184,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f75b54d954484273b6f0c5c2283a0ee2","type":"text","conversion_output":true,"text":"analgesia.","text_display":" analgesia.","confidence":1,"confidence_rate":1},{"cnt":[[245,2243],[1747,2243],[1747,2295],[245,2295]],"region":{"top_left_x":244,"top_left_y":2242,"width":1503,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"401bf1955af74aaaa126fb5015f73a7f","type":"text","conversion_output":true,"text":"Both groups could also be given oral, rectal, or intravenous paracetamol. Monitoring and","text_display":"\n\nBoth groups could also be given oral, rectal, or intravenous paracetamol. Monitoring and","confidence":1,"confidence_rate":1},{"cnt":[[245,2305],[1858,2305],[1858,2357],[245,2357]],"region":{"top_left_x":244,"top_left_y":2305,"width":1615,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23d399e0d0c94ec79e5fcc7449e67fe4","type":"text","conversion_output":true,"text":"recording were identical in both groups, with heart rate, blood pressure, oxygen saturation, and","text_display":" recording were identical in both groups, with heart rate, blood pressure, oxygen saturation, and","confidence":1,"confidence_rate":1},{"cnt":[[245,2368],[1652,2368],[1652,2419],[245,2419]],"region":{"top_left_x":244,"top_left_y":2367,"width":1409,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"870cb88146f94dd2bcef20ad68eb023c","type":"text","conversion_output":true,"text":"expired sevoflurane concentrations (where applicable) every 5 min. In both groups,","text_display":" expired sevoflurane concentrations (where applicable) every 5 min. In both groups,","confidence":0.7119140625,"confidence_rate":0.9962315842166892}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"5d26818e-2d50-4a6d-8d84-6ff93172aad9-3","page":3,"lines":[{"cnt":[[245,269],[1826,269],[1826,320],[245,320]],"region":{"top_left_x":244,"top_left_y":268,"width":1583,"height":53},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc2c45e95383494a98e45a736e2f7abc","type":"text","conversion_output":true,"text":"intraoperative serum glucose values were measured after induction, and rescue protocols for","text_display":"\nintraoperative serum glucose values were measured after induction, and rescue protocols for","confidence":1,"confidence_rate":1},{"cnt":[[245,331],[1532,331],[1532,380],[245,380]],"region":{"top_left_x":244,"top_left_y":330,"width":1288,"height":51},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6cd48ad69614fb389b049855c8e2f28","type":"text","conversion_output":true,"text":"hypoglycaemia, hypotension, and hypoxaemia were applied as appropriate.","text_display":" hypoglycaemia, hypotension, and hypoxaemia were applied as appropriate.","confidence":1,"confidence_rate":1},{"cnt":[[236,417],[438,417],[438,477],[236,477]],"region":{"top_left_x":236,"top_left_y":416,"width":203,"height":61},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59631cc480b343e5935f8e6bc2a1d660","type":"section_header","conversion_output":false,"children_ids":["f22c8677ec704203be419b6e9d853fe5"],"text":"","text_display":""},{"cnt":[[245,423],[432,423],[432,466],[245,466]],"region":{"top_left_x":244,"top_left_y":423,"width":188,"height":44},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f22c8677ec704203be419b6e9d853fe5","type":"text","conversion_output":true,"parent_id":"59631cc480b343e5935f8e6bc2a1d660","text":"Outcomes","text_display":"\n\n\\section*{Outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[245,535],[1846,535],[1846,587],[245,587]],"region":{"top_left_x":244,"top_left_y":534,"width":1602,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3d4d001739c4167b4b3e0503936309d","type":"text","conversion_output":true,"text":"The primary outcome measure was the Wechsler Preschool and Primary Scale of Intelligence,","text_display":"\n\nThe primary outcome measure was the Wechsler Preschool and Primary Scale of Intelligence,","confidence":1,"confidence_rate":1},{"cnt":[[245,597],[1755,597],[1755,647],[245,647]],"region":{"top_left_x":244,"top_left_y":597,"width":1512,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ac86e26369c4734bf3287f4a4bccaa8","type":"text","conversion_output":true,"text":"third edition (WPPSI-III) full-scale intelligence quotient (FSIQ) score. 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of the treatment effect in the direction of non-equivalence.","text_display":" ensure a conservative estimate of the treatment effect in the direction of non-equivalence.","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[245,604],[1760,604],[1760,655],[245,655]],"region":{"top_left_x":244,"top_left_y":603,"width":1516,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3e6d3d8be2f482894bdbc759e9f3485","type":"text","conversion_output":true,"text":"Although it is best practice to analyse outcomes on an intention-to-treat basis, there were","text_display":" Although it is best practice to analyse outcomes on an intention-to-treat basis, there 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who had some exposure to general anaesthesia, particularly if the","confidence":1,"confidence_rate":1},{"cnt":[[245,793],[1820,793],[1820,840],[245,840]],"region":{"top_left_x":244,"top_left_y":792,"width":1576,"height":49},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3210503c040943698bdf8ca699f5a13e","type":"text","conversion_output":true,"text":"awake-regional anaesthesia failed). If all infants were analysed on an intention-to-treat basis,","text_display":" awake-regional anaesthesia failed). If all infants were analysed on an intention-to-treat basis,","confidence":1,"confidence_rate":1},{"cnt":[[245,855],[1800,855],[1800,904],[245,904]],"region":{"top_left_x":244,"top_left_y":855,"width":1557,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"debdc707164b47f499db65b47183bbad","type":"text","conversion_output":true,"text":"this switching from one randomised treatment to the other could dilute the potential effect of","text_display":" this switching from one randomised treatment to the other could dilute the potential effect of","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1369,911],[1369,967],[245,967]],"region":{"top_left_x":244,"top_left_y":910,"width":1125,"height":57},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d023b0050abe4ba8b1a16369d1167040","type":"text","conversion_output":true,"text":"general anaesthesia and thus bias the trial towards equivalence. \\({ }^{22}\\)","text_display":" general anaesthesia and thus bias the trial towards equivalence. \\({ }^{22}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1021],[1798,1021],[1798,1072],[245,1072]],"region":{"top_left_x":244,"top_left_y":1020,"width":1555,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50ff6f78e749437abc401e9567d9ef52","type":"text","conversion_output":true,"text":"Equivalence was defined a priori as the \\(95 \\% CI\\) of the difference in means of the FSIQ lying","text_display":"\n\nEquivalence was defined a priori as the \\(95 \\% CI\\) of the difference in means of the FSIQ lying","confidence":0.931124286587135,"confidence_rate":0.9992936900230235},{"cnt":[[245,1083],[1863,1083],[1863,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1082,"width":1619,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7fdef6be2acf418c90b41e854afc7dc0","type":"text","conversion_output":true,"text":"within -5 and +5 IQ points. Intention-to-treat analyses were also planned. All Cls are two-sided.","text_display":" within -5 and +5 IQ points. Intention-to-treat analyses were also planned. All Cls are two-sided.","confidence":0.96533203125,"confidence_rate":0.9996733574057123},{"cnt":[[245,1188],[1794,1188],[1794,1235],[245,1235]],"region":{"top_left_x":244,"top_left_y":1188,"width":1550,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19e05277087040eaa42c48660a884ad6","type":"text","conversion_output":true,"text":"The sample size was based on the primary outcome. Assuming an expected difference of 1","text_display":"\n\nThe sample size was based on the primary outcome. Assuming an expected difference of 1","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[245,1250],[1772,1250],[1772,1300],[245,1300]],"region":{"top_left_x":244,"top_left_y":1250,"width":1529,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e30c59d2678840ef992b7c17ff203839","type":"text","conversion_output":true,"text":"standardised score point, a standard deviation of 15 , and a \\(90 \\%\\) chance that a \\(95 \\% CI\\) will","text_display":" standardised score point, a standard deviation of 15 , and a \\(90 \\%\\) chance that a \\(95 \\% CI\\) will","confidence":0.5131009700708091,"confidence_rate":0.9937246535952409},{"cnt":[[245,1315],[1687,1315],[1687,1362],[245,1362]],"region":{"top_left_x":244,"top_left_y":1314,"width":1443,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2d7104efd6649aca08a9367b8a660b4","type":"text","conversion_output":true,"text":"exclude a difference of more than 5 points (the largest difference acceptable to show","text_display":" exclude a difference of more than 5 points (the largest difference acceptable to show","confidence":0.9873046875,"confidence_rate":0.9998626267851773},{"cnt":[[245,1375],[1798,1375],[1798,1424],[245,1424]],"region":{"top_left_x":244,"top_left_y":1375,"width":1555,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6469e5c22f864be3bb9bbc8e0b8b310a","type":"text","conversion_output":true,"text":"equivalence), the trial would need 598 infants. The sample size formula used was based on","text_display":" equivalence), the trial would need 598 infants. The sample size formula used was based on","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[1824,1439],[1824,1489],[245,1489]],"region":{"top_left_x":244,"top_left_y":1439,"width":1581,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c79117e0c63e4515968640ab532a3704","type":"text","conversion_output":true,"text":"approximations to the normal distribution, and used a two one-sided test procedure. Enrolling","text_display":" approximations to the normal distribution, and used a two one-sided test procedure. Enrolling","confidence":0.9990236759185791,"confidence_rate":0.9999900326925697},{"cnt":[[245,1500],[1820,1500],[1820,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1499,"width":1576,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a112f4e0209e46de89a745e479128180","type":"text","conversion_output":true,"text":"roughly 720 participants would allow for \\(10 \\%\\) loss to follow-up and \\(10 \\%\\) with a major protocol","text_display":" roughly 720 participants would allow for \\(10 \\%\\) loss to follow-up and \\(10 \\%\\) with a major protocol","confidence":0.9843893051147461,"confidence_rate":0.9998515787052127},{"cnt":[[245,1564],[402,1564],[402,1605],[245,1605]],"region":{"top_left_x":244,"top_left_y":1564,"width":158,"height":41},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ea4d07658cd449fa5c24f78a5d61f79","type":"text","conversion_output":true,"text":"violation.","text_display":" violation.","confidence":1,"confidence_rate":1},{"cnt":[[245,1667],[1867,1667],[1867,1717],[245,1717]],"region":{"top_left_x":244,"top_left_y":1667,"width":1623,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69bc77cfa3b849a49ffbc1e3b73bc8e9","type":"text","conversion_output":true,"text":"We used multiple imputation under a multivariate normal distribution to impute missing outcome","text_display":"\n\nWe used multiple imputation under a multivariate normal distribution to impute missing outcome","confidence":1,"confidence_rate":1},{"cnt":[[245,1729],[1828,1729],[1828,1777],[245,1777]],"region":{"top_left_x":244,"top_left_y":1729,"width":1585,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fed5fd07de3c44409912135d666c4646","type":"text","conversion_output":true,"text":"data in the primary analysis of all outcomes, with a sensitivity analysis done on only complete","text_display":" data in the primary analysis of all outcomes, with a sensitivity analysis done on only complete","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1876,1792],[1876,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1791,"width":1632,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c075b9a231c4712b35497f83e2f3878","type":"text","conversion_output":true,"text":"cases. Multiple imputations were done with the mi impute mvn statement in Stata (version 14.2).","text_display":" cases. Multiple imputations were done with the mi impute mvn statement in Stata (version 14.2).","confidence":0.994140625,"confidence_rate":0.9999412356418027},{"cnt":[[245,1852],[1852,1852],[1852,1901],[245,1901]],"region":{"top_left_x":244,"top_left_y":1851,"width":1608,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d781a39a8c64c0da7f3c7c72bf84ee7","type":"text","conversion_output":true,"text":"The variables used in the multiple imputation models included baseline, post-randomisation, 2-","text_display":" The variables used in the multiple imputation models included baseline, post-randomisation, 2","confidence":0.94482421875,"confidence_rate":0.9994268675284941},{"cnt":[[245,1916],[1790,1916],[1790,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1916,"width":1546,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c076910af45946e28c7f38ddad6c0452","type":"text","conversion_output":true,"text":"year cognitive variables, and 5 -year outcome variables. A number of prespecified variables","text_display":"year cognitive variables, and 5 -year outcome variables. A number of prespecified variables","confidence":1,"confidence_rate":1},{"cnt":[[245,1981],[1807,1979],[1807,2028],[245,2030]],"region":{"top_left_x":244,"top_left_y":1978,"width":1563,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06874abcc5d5479f9e7812737821a48f","type":"text","conversion_output":true,"text":"were used as possible predictor variables within the imputation approach, including baseline","text_display":" were used as possible predictor variables within the imputation approach, including baseline","confidence":1,"confidence_rate":1},{"cnt":[[245,2041],[1766,2041],[1766,2090],[245,2090]],"region":{"top_left_x":244,"top_left_y":2041,"width":1523,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53fcc33457d3433f84b2f38b35fafc5f","type":"text","conversion_output":true,"text":"variables (anaesthesia group, country, sex, gestational age at birth, birthweight, antenatal","text_display":" variables (anaesthesia group, country, sex, gestational age at birth, birthweight, antenatal","confidence":1,"confidence_rate":1},{"cnt":[[245,2105],[1794,2105],[1794,2153],[245,2153]],"region":{"top_left_x":244,"top_left_y":2105,"width":1550,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af06447af70c48adb35dc6f0f0eb1bbb","type":"text","conversion_output":true,"text":"steroids received by mother, mother's education, and maternal age \\(<21\\) years), variables at","text_display":" steroids received by mother, mother's education, and maternal age \\(<21\\) years), variables at","confidence":0.9853515625,"confidence_rate":0.9998494318952309},{"cnt":[[245,2168],[1768,2168],[1768,2215],[245,2215]],"region":{"top_left_x":244,"top_left_y":2167,"width":1525,"height":49},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"299abc4464c74474b699b79edc040347","type":"text","conversion_output":true,"text":"surgery (need for fluid bolus for hypotension, duration of surgery, significant postoperative","text_display":" surgery (need for fluid bolus for hypotension, duration of surgery, significant postoperative","confidence":1,"confidence_rate":1},{"cnt":[[245,2230],[1841,2230],[1841,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2230,"width":1598,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f9fb9e940c1f40f5a851e3fdea7e9c03","type":"text","conversion_output":true,"text":"apnoea, and age), variables at age 2 years (composite cognitive, language, motor and social-","text_display":" apnoea, and age), variables at age 2 years (composite cognitive, language, motor and social","confidence":1,"confidence_rate":1},{"cnt":[[245,2292],[1794,2292],[1794,2340],[245,2340]],"region":{"top_left_x":244,"top_left_y":2292,"width":1550,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"79219a65a20c449c99e73cb2fca8096d","type":"text","conversion_output":true,"text":"emotional score on the Bayley Scales of Infant and Toddler Development, third edition; any","text_display":"emotional score on the Bayley Scales of Infant and Toddler Development, third edition; any","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,2355],[1729,2355],[1729,2402],[245,2402]],"region":{"top_left_x":244,"top_left_y":2354,"width":1486,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"307e1d99d75e43d5887c5f2cecfabe8d","type":"text","conversion_output":true,"text":"additional anaesthetic exposures since the inguinal herniorrhaphy; any interventions for","text_display":" additional anaesthetic exposures since the inguinal herniorrhaphy; any interventions for","confidence":1,"confidence_rate":1},{"cnt":[[245,2419],[1858,2419],[1858,2466],[245,2466]],"region":{"top_left_x":244,"top_left_y":2419,"width":1615,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"693d149f447f42b98846c494128e8c61","type":"text","conversion_output":true,"text":"neurodevelopmental problems; and any other neurological abnormality), and variables at age 5","text_display":" neurodevelopmental problems; and any other neurological abnormality), and variables at age 5","confidence":0.9990236759185791,"confidence_rate":0.999989825041388}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"5d26818e-2d50-4a6d-8d84-6ff93172aad9-5","page":5,"lines":[{"cnt":[[243,266],[1790,266],[1790,320],[243,320]],"region":{"top_left_x":242,"top_left_y":266,"width":1548,"height":55},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1b410166df24478af1f3535946516c9","type":"text","conversion_output":true,"text":"years (WPPSI-III FSIQ, any chronic illness, any additional anaesthetic exposures since the","text_display":"\nyears (WPPSI-III FSIQ, any chronic illness, any additional anaesthetic exposures since the","confidence":1,"confidence_rate":1},{"cnt":[[243,329],[1704,329],[1704,382],[243,382]],"region":{"top_left_x":242,"top_left_y":328,"width":1462,"height":55},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56b125ae4ab143ce9f66742a76f88611","type":"text","conversion_output":true,"text":"inguinal herniorrhaphy, total length of any readmission to hospital, cerebral palsy, any","text_display":" inguinal herniorrhaphy, total length of any readmission to hospital, cerebral palsy, any","confidence":1,"confidence_rate":1},{"cnt":[[243,391],[1865,391],[1865,445],[243,445]],"region":{"top_left_x":242,"top_left_y":391,"width":1623,"height":54},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f93ee2521c145599ea188c9929860ac","type":"text","conversion_output":true,"text":"interventions for neurodevelopmental problems, and any other neurological abnormality). Since","text_display":" interventions for neurodevelopmental problems, and any other neurological abnormality). Since","confidence":1,"confidence_rate":1},{"cnt":[[245,451],[1858,451],[1858,507],[245,507]],"region":{"top_left_x":244,"top_left_y":451,"width":1615,"height":57},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c63dab942774d73b256cb9f6bab4882","type":"text","conversion_output":true,"text":"most of these variables also have missingness, they were also imputed where necessary. With","text_display":" most of these variables also have missingness, they were also imputed where necessary. With","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1876,516],[1876,569],[245,569]],"region":{"top_left_x":244,"top_left_y":515,"width":1632,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"710e824f08ed4c1db2c1a9df90d57523","type":"text","conversion_output":true,"text":"many missing observations, these multiple imputation models did not always converge, in which","text_display":" many missing observations, these multiple imputation models did not always converge, in which","confidence":1,"confidence_rate":1},{"cnt":[[245,578],[1846,578],[1846,632],[245,632]],"region":{"top_left_x":244,"top_left_y":577,"width":1602,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3cd9bb43bb9a48fd92d5c3239b022b33","type":"text","conversion_output":true,"text":"case, to ensure convergence of models, applicable variables were not included. The variables","text_display":" case, to ensure convergence of models, applicable variables were not included. The variables","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,640],[1515,640],[1515,694],[245,694]],"region":{"top_left_x":244,"top_left_y":640,"width":1271,"height":54},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ebf0d717f1db40b3ae6796d705a7fa5f","type":"text","conversion_output":true,"text":"used in the analysis model were always included in the imputation models.","text_display":" used in the analysis model were always included in the imputation models.","confidence":1,"confidence_rate":1},{"cnt":[[245,743],[1841,743],[1841,801],[245,801]],"region":{"top_left_x":244,"top_left_y":743,"width":1598,"height":59},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"821f37de85b0465a8ce6a1213ca52ffc","type":"text","conversion_output":true,"text":"For all continuous outcomes, linear regression was used with the factor variables anaesthesia","text_display":"\n\nFor all continuous outcomes, linear regression was used with the factor variables anaesthesia","confidence":1,"confidence_rate":1},{"cnt":[[245,808],[1858,808],[1858,862],[245,862]],"region":{"top_left_x":244,"top_left_y":807,"width":1615,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a529e0bc23541029bef5f32b2196a74","type":"text","conversion_output":true,"text":"group (awake-regional anaesthesia and general anaesthesia), with gestational age at birth and","text_display":" group (awake-regional anaesthesia and general anaesthesia), with gestational age at birth and","confidence":1,"confidence_rate":1},{"cnt":[[245,870],[1611,870],[1611,924],[245,924]],"region":{"top_left_x":244,"top_left_y":870,"width":1368,"height":54},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b5ca171184f4a118e52dcb35262ba44","type":"text","conversion_output":true,"text":"country as fixed effects. Adjusted mean differences are presented with \\(95 \\%\\) Cls.","text_display":" country as fixed effects. Adjusted mean differences are presented with \\(95 \\%\\) Cls.","confidence":0.783091330435127,"confidence_rate":0.9971935323174168},{"cnt":[[243,975],[1858,975],[1858,1029],[243,1029]],"region":{"top_left_x":242,"top_left_y":975,"width":1617,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa58927d616f48189a139aa281d12e79","type":"text","conversion_output":true,"text":"All binary outcomes were analysed with generalised linear models with binomial link function to","text_display":"\n\nAll binary outcomes were analysed with generalised linear models with binomial link function to","confidence":1,"confidence_rate":1},{"cnt":[[245,1036],[1858,1036],[1858,1091],[245,1091]],"region":{"top_left_x":244,"top_left_y":1035,"width":1615,"height":57},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c93640bc24b4a198a3dd9ceab8a8d13","type":"text","conversion_output":true,"text":"enable estimation of risk ratios, adjusting for the same factors as for the linear regression. Risk","text_display":" enable estimation of risk ratios, adjusting for the same factors as for the linear regression. Risk","confidence":1,"confidence_rate":1},{"cnt":[[245,1100],[840,1100],[840,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1100,"width":597,"height":54},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"053a5241bf724c8cae51f705c64fb415","type":"text","conversion_output":true,"text":"ratios are presented with 95\\% Cls.","text_display":" ratios are presented with 95\\% Cls.","confidence":0.39426684379577637,"confidence_rate":0.9764177092440672},{"cnt":[[245,1203],[1783,1203],[1783,1257],[245,1257]],"region":{"top_left_x":244,"top_left_y":1203,"width":1540,"height":54},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ab1ac211ead4e81aa8085ca82570832","type":"text","conversion_output":true,"text":"The following subgroup analyses were prespecified in the statistical analysis plan: country,","text_display":"\n\nThe following subgroup analyses were prespecified in the statistical analysis plan: country,","confidence":1,"confidence_rate":1},{"cnt":[[245,1265],[1777,1265],[1777,1321],[245,1321]],"region":{"top_left_x":244,"top_left_y":1265,"width":1533,"height":57},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d2cf5974e424dbf9899365c104d13b4","type":"text","conversion_output":true,"text":"duration of surgery ( \\(\\geq 120 min\\) or \\(<120 min\\) ), and age at surgery ( \\(>70\\) days or \\(\\leq 70\\) days). A","text_display":" duration of surgery ( \\(\\geq 120 min\\) or \\(<120 min\\) ), and age at surgery ( \\(>70\\) days or \\(\\leq 70\\) days). 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All analyses were done in Stata (version 14.2).","text_display":" and \\(95 \\%\\) Cls. 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The","text_display":" Research Network (number 6635; ISRCTN ID 12437565; MREC number 07/S0709/20). The","confidence":1,"confidence_rate":1},{"cnt":[[245,1800],[1697,1800],[1697,1863],[245,1863]],"region":{"top_left_x":244,"top_left_y":1800,"width":1454,"height":63},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1732ddd7b814b78b21cc6ce917fa110","type":"text","conversion_output":true,"text":"statistical analysis plan is available at ANZCTR (number ACTRN12606000441516). \\({ }^{23}\\)","text_display":" statistical analysis plan is available at ANZCTR (number ACTRN12606000441516). \\({ }^{23}\\)","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]}]}

documents/10.1016_s0140-6736(18)32485-1/sap.lines.json

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trial comparing neurodevelopmental outcome at age 5 years, in infants randomised","confidence":1,"confidence_rate":1},{"cnt":[[245,1152],[1841,1152],[1841,1201],[245,1201]],"region":{"top_left_x":244,"top_left_y":1151,"width":1598,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"effa5ce78b9f4bf4abd1bdf57278ddf8","type":"text","conversion_output":true,"text":"to receive awake-regional anaesthesia or general anaesthesia for inguinal herniorrhaphy. The","text_display":" to receive awake-regional anaesthesia or general anaesthesia for inguinal herniorrhaphy. The","confidence":1,"confidence_rate":1},{"cnt":[[245,1214],[1871,1214],[1871,1261],[245,1261]],"region":{"top_left_x":244,"top_left_y":1213,"width":1628,"height":49},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4385345d261947109fb1a0ab136053cd","type":"text","conversion_output":true,"text":"trial was done at 28 hospitals in Australia, Italy, the USA, the UK, Canada, the Netherlands, and","text_display":" trial was done at 28 hospitals in Australia, Italy, the USA, the UK, Canada, the Netherlands, and","confidence":1,"confidence_rate":1},{"cnt":[[245,1276],[1790,1276],[1790,1326],[245,1326]],"region":{"top_left_x":244,"top_left_y":1276,"width":1546,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a65b344834254d7c8c87bcc7b0b20e66","type":"text","conversion_output":true,"text":"New Zealand. Institutional review board or human research ethics committee approval was","text_display":" New Zealand. Institutional review board or human research ethics committee approval was","confidence":1,"confidence_rate":1},{"cnt":[[245,1341],[1824,1341],[1824,1388],[245,1388]],"region":{"top_left_x":244,"top_left_y":1340,"width":1581,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"040f42b378744468a2e33b4f9cbc5b11","type":"text","conversion_output":true,"text":"obtained at each site, and written informed consent was obtained from the infant's parents or","text_display":" obtained at each site, and written informed consent was obtained from the infant's parents or","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1240,1396],[1240,1450],[245,1450]],"region":{"top_left_x":244,"top_left_y":1396,"width":996,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24eb5cba9baa4d5e9a66dd5967263f92","type":"text","conversion_output":true,"text":"guardians. A summary of the protocol is available online. \\({ }^{21}\\)","text_display":" guardians. 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Exclusion criteria were any","text_display":" than 26 weeks' gestation, and scheduled for inguinal herniorrhaphy. 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We identified eligible infants from operating room schedules or at preadmission","text_display":" language. We identified eligible infants from operating room schedules or at preadmission","confidence":1,"confidence_rate":1},{"cnt":[[245,2194],[1656,2194],[1656,2241],[245,2241]],"region":{"top_left_x":244,"top_left_y":2193,"width":1413,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2eb917b4a15341a9b3810dc0235ba497","type":"text","conversion_output":true,"text":"clinics and recruited in the clinic or in the preadmission areas of the operating floor.","text_display":" clinics and recruited in the clinic or in the preadmission areas of the operating floor.","confidence":1,"confidence_rate":1},{"cnt":[[245,2286],[737,2286],[737,2335],[245,2335]],"region":{"top_left_x":244,"top_left_y":2285,"width":493,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"329ff93c388c423c9b818bb4b6f37bc0","type":"text","conversion_output":true,"text":"Randomisation and masking","text_display":"\n\nRandomisation and masking","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"5d26818e-2d50-4a6d-8d84-6ff93172aad9-2","page":2,"lines":[{"cnt":[[245,269],[1835,269],[1835,320],[245,320]],"region":{"top_left_x":244,"top_left_y":268,"width":1591,"height":53},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe6ee7c553e74a3e996f230beb7ccc75","type":"text","conversion_output":true,"text":"Infants were randomly assigned ( \\(1: 1\\) ) to receive either general anaesthesia or awake-regional","text_display":"\n\nInfants were randomly assigned ( \\(1: 1\\) ) to receive either general anaesthesia or awake-regional","confidence":0.956228494644165,"confidence_rate":0.9995612885820555},{"cnt":[[245,329],[1876,329],[1876,380],[245,380]],"region":{"top_left_x":244,"top_left_y":328,"width":1632,"height":53},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83dc1e8af0d54396b800dfd3aaac5045","type":"text","conversion_output":true,"text":"anaesthesia using a \\(24- h\\) web-based randomisation service managed by the Data Management","text_display":" anaesthesia using a \\(24- h\\) web-based randomisation service managed by the Data Management","confidence":0.9560424741357565,"confidence_rate":0.9995414017403286},{"cnt":[[245,391],[1665,391],[1665,445],[245,445]],"region":{"top_left_x":244,"top_left_y":391,"width":1422,"height":54},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d06b5f998d914f96ac00672087015b66","type":"text","conversion_output":true,"text":"and Analysis Centre, Department of Public Health, University of Adelaide, Australia.","text_display":" and Analysis Centre, Department of Public Health, University of Adelaide, Australia.","confidence":1,"confidence_rate":1},{"cnt":[[245,455],[1818,455],[1818,505],[245,505]],"region":{"top_left_x":244,"top_left_y":455,"width":1574,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95e91cfe0c324feba88496d2e47bec7e","type":"text","conversion_output":true,"text":"Randomisation was done in blocks of two or four in a computer-generated random-allocation","text_display":" Randomisation was done in blocks of two or four in a computer-generated random-allocation","confidence":1,"confidence_rate":1},{"cnt":[[245,518],[1876,518],[1876,569],[245,569]],"region":{"top_left_x":244,"top_left_y":517,"width":1632,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0852571d8037464db5efc07466012409","type":"text","conversion_output":true,"text":"sequence, with stratification by site and by gestational age at birth ( 26 weeks to 29 weeks and 6","text_display":" sequence, with stratification by site and by gestational age at birth ( 26 weeks to 29 weeks and 6","confidence":0.9985356330871582,"confidence_rate":0.9999864312018168},{"cnt":[[245,580],[1837,580],[1837,629],[245,629]],"region":{"top_left_x":244,"top_left_y":580,"width":1593,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86da3bbb3469421480e0b8b329d6db03","type":"text","conversion_output":true,"text":"days, 30 weeks to 36 weeks and 6 days, and 37 weeks or more). The anaesthetist was aware","text_display":" days, 30 weeks to 36 weeks and 6 days, and 37 weeks or more). The anaesthetist was aware","confidence":0.9960954189300537,"confidence_rate":0.9999627414193785},{"cnt":[[245,645],[1794,645],[1794,694],[245,694]],"region":{"top_left_x":244,"top_left_y":644,"width":1550,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"633b4b0799f84870a4ba2fc5a61ffe93","type":"text","conversion_output":true,"text":"of group allocation, but individuals who administered the neurodevelopmental assessments","text_display":" of group allocation, but individuals who administered the neurodevelopmental assessments","confidence":1,"confidence_rate":1},{"cnt":[[245,705],[1790,705],[1790,754],[245,754]],"region":{"top_left_x":244,"top_left_y":704,"width":1546,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca4045a27ede48ecb9449565ad2492eb","type":"text","conversion_output":true,"text":"were not. Parents who asked about their infant's group allocation were informed and told to","text_display":" were not. Parents who asked about their infant's group allocation were informed and told to","confidence":1,"confidence_rate":1},{"cnt":[[245,769],[1725,769],[1725,819],[245,819]],"region":{"top_left_x":244,"top_left_y":769,"width":1482,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99121835cd76452d955445097b0de1b3","type":"text","conversion_output":true,"text":"mask this information from assessors. After assessments were completed, parents and","text_display":" mask this information from assessors. After assessments were completed, parents and","confidence":1,"confidence_rate":1},{"cnt":[[245,829],[1285,829],[1285,881],[245,881]],"region":{"top_left_x":244,"top_left_y":829,"width":1041,"height":52},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f96b81083af14532a2ff14b68da0524a","type":"text","conversion_output":true,"text":"assessors were asked if they were aware of group allocation.","text_display":" assessors were asked if they were aware of group allocation.","confidence":1,"confidence_rate":1},{"cnt":[[241,920],[455,920],[455,973],[241,973]],"region":{"top_left_x":240,"top_left_y":919,"width":216,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b85de132a7a47d18f2fdb517527ce5a","type":"section_header","conversion_output":false,"children_ids":["5118ec1a61b347fe851891a5903f53a3"],"text":"","text_display":""},{"cnt":[[245,924],[449,924],[449,969],[245,969]],"region":{"top_left_x":244,"top_left_y":923,"width":206,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5118ec1a61b347fe851891a5903f53a3","type":"text","conversion_output":true,"parent_id":"4b85de132a7a47d18f2fdb517527ce5a","text":"Procedures","text_display":"\n\n\\section*{Procedures}","confidence":1,"confidence_rate":1},{"cnt":[[245,1036],[1669,1036],[1669,1085],[245,1085]],"region":{"top_left_x":244,"top_left_y":1035,"width":1426,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"494beaf662894696b02b38178a6f8541","type":"text","conversion_output":true,"text":"The awake-regional group received a spinal, caudal, or combined caudal and spinal","text_display":"\n\nThe awake-regional group received a spinal, caudal, or combined caudal and spinal","confidence":1,"confidence_rate":1},{"cnt":[[245,1096],[1865,1096],[1865,1147],[245,1147]],"region":{"top_left_x":244,"top_left_y":1095,"width":1621,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88fc3ae8bcb44aafbf553e34c431e0dc","type":"text","conversion_output":true,"text":"anaesthetic, according to institutional preferences. Bupivacaine or levobupivacaine at a dose of","text_display":" anaesthetic, according to institutional preferences. Bupivacaine or levobupivacaine at a dose of","confidence":1,"confidence_rate":1},{"cnt":[[245,1156],[1815,1156],[1815,1210],[245,1210]],"region":{"top_left_x":244,"top_left_y":1155,"width":1572,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3feb3852239149c8b83202bc556b053a","type":"text","conversion_output":true,"text":"\\(0 \\cdot 75-1 mg / kg\\) was administered for spinal anaesthesia. Caudal anaesthesia was with \\(0 \\cdot 25 \\%\\)","text_display":" \\(0 \\cdot 75-1 mg / kg\\) was administered for spinal anaesthesia. Caudal anaesthesia was with \\(0 \\cdot 25 \\%\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[1850,1220],[1850,1274],[245,1274]],"region":{"top_left_x":244,"top_left_y":1220,"width":1606,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cf9d018ac4949988c2aa2ad0d39688d","type":"text","conversion_output":true,"text":"bupivacaine or levobupivacaine up to a total dose of \\(2.5 mg / kg\\). In the USA, several patients in","text_display":" bupivacaine or levobupivacaine up to a total dose of \\(2.5 mg / kg\\). In the USA, several patients in","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[243,1285],[1790,1285],[1790,1334],[243,1334]],"region":{"top_left_x":242,"top_left_y":1284,"width":1548,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a02c49bab25c47aaa11bc05199074a16","type":"text","conversion_output":true,"text":"whom it was known that the surgery would take longer than 1 h were also administered \\(3 \\%\\)","text_display":" whom it was known that the surgery would take longer than 1 h were also administered \\(3 \\%\\)","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[245,1347],[1852,1347],[1852,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1347,"width":1608,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e3febceebf64c81aad05907eed7e4c0","type":"text","conversion_output":true,"text":"chloroprocaine via a caudal catheter (loading bolus of \\(3 \\%\\) chloroprocaine \\(1 mL / kg\\) over several","text_display":" chloroprocaine via a caudal catheter (loading bolus of \\(3 \\%\\) chloroprocaine \\(1 mL / kg\\) over several","confidence":0.9990234375,"confidence_rate":0.9999910363736797},{"cnt":[[245,1409],[1828,1409],[1828,1459],[245,1459]],"region":{"top_left_x":244,"top_left_y":1409,"width":1585,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1998b7b3c04449dc9be1f62dd4243a26","type":"text","conversion_output":true,"text":"minutes and then an infusion at \\(1-2 mL / kg\\) per h). Additional ilioinguinal and field blocks were","text_display":" minutes and then an infusion at \\(1-2 mL / kg\\) per h). Additional ilioinguinal and field blocks were","confidence":0.57763671875,"confidence_rate":0.9949313141559091},{"cnt":[[245,1474],[1865,1474],[1865,1523],[245,1523]],"region":{"top_left_x":244,"top_left_y":1473,"width":1621,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5fd60b2c9de4680858e0133ff9524b3","type":"text","conversion_output":true,"text":"used according to surgical preference. Oral sucrose was given if the child was unsettled, but no","text_display":" used according to surgical preference. Oral sucrose was given if the child was unsettled, but no","confidence":1,"confidence_rate":1},{"cnt":[[245,1534],[1766,1534],[1766,1583],[245,1583]],"region":{"top_left_x":244,"top_left_y":1533,"width":1523,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d85fc9015064965853ff250f2c37ddf","type":"text","conversion_output":true,"text":"other pharmacological sedation was permitted. Infants who showed agitation that was not","text_display":" other pharmacological sedation was permitted. Infants who showed agitation that was not","confidence":1,"confidence_rate":1},{"cnt":[[245,1598],[1798,1598],[1798,1648],[245,1648]],"region":{"top_left_x":244,"top_left_y":1598,"width":1555,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b22314781b324a1ca7fcd375cd08ecd0","type":"text","conversion_output":true,"text":"resolved by oral sucrose, or in whom the awake-regional anaesthetic was inadequate, were","text_display":" resolved by oral sucrose, or in whom the awake-regional anaesthetic was inadequate, were","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[1850,1659],[1850,1708],[245,1708]],"region":{"top_left_x":244,"top_left_y":1658,"width":1606,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15d13e3c76044417a8e82910d4cd16c8","type":"text","conversion_output":true,"text":"treated with sevoflurane. The administration of sevoflurane, nitrous oxide, or any other general","text_display":" treated with sevoflurane. The administration of sevoflurane, nitrous oxide, or any other general","confidence":1,"confidence_rate":1},{"cnt":[[245,1723],[1283,1723],[1283,1772],[245,1772]],"region":{"top_left_x":244,"top_left_y":1723,"width":1039,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b347f94fedcb424c9c1afc3cf2f82bc4","type":"text","conversion_output":true,"text":"anaesthetic in this group was considered a protocol violation.","text_display":" anaesthetic in this group was considered a protocol violation.","confidence":1,"confidence_rate":1},{"cnt":[[245,1826],[1858,1826],[1858,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1826,"width":1615,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22a6c9f2b52f432aadaca6fa728c2321","type":"text","conversion_output":true,"text":"The general anaesthesia group received sevoflurane for induction and maintenance in a mix of","text_display":"\n\nThe general anaesthesia group received sevoflurane for induction and maintenance in a mix of","confidence":1,"confidence_rate":1},{"cnt":[[245,1886],[1880,1886],[1880,1940],[245,1940]],"region":{"top_left_x":244,"top_left_y":1886,"width":1636,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54e7ebd0e3a5489dabe666fdfa6e2211","type":"text","conversion_output":true,"text":"air and oxygen. The concentration of sevoflurane, choice of airway device, ventilation technique,","text_display":" air and oxygen. The concentration of sevoflurane, choice of airway device, ventilation technique,","confidence":1,"confidence_rate":1},{"cnt":[[245,1951],[1760,1951],[1760,2000],[245,2000]],"region":{"top_left_x":244,"top_left_y":1950,"width":1516,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f825677bb09e4be88b9ea02a59375e00","type":"text","conversion_output":true,"text":"and use of neuromuscular blocking agents were left to the preference of the anaesthetist.","text_display":" and use of neuromuscular blocking agents were left to the preference of the anaesthetist.","confidence":1,"confidence_rate":1},{"cnt":[[245,2011],[1639,2011],[1639,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2010,"width":1396,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d619de542e304459bd84212f8e798f89","type":"text","conversion_output":true,"text":"Supplemental opioids and nitrous oxide were not allowed, but caudal, ilioinguinal-","text_display":" Supplemental opioids and nitrous oxide were not allowed, but caudal, ilioinguinal","confidence":1,"confidence_rate":1},{"cnt":[[245,2075],[1727,2075],[1727,2127],[245,2127]],"region":{"top_left_x":244,"top_left_y":2075,"width":1484,"height":52},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7fec47133c7f496e817931be9bc67f87","type":"text","conversion_output":true,"text":"iliohypogastric, or field blocks with bupivacaine were permitted to provide postoperative","text_display":"iliohypogastric, or field blocks with bupivacaine were permitted to provide postoperative","confidence":1,"confidence_rate":1},{"cnt":[[245,2140],[428,2140],[428,2189],[245,2189]],"region":{"top_left_x":244,"top_left_y":2139,"width":184,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f75b54d954484273b6f0c5c2283a0ee2","type":"text","conversion_output":true,"text":"analgesia.","text_display":" analgesia.","confidence":1,"confidence_rate":1},{"cnt":[[245,2243],[1747,2243],[1747,2295],[245,2295]],"region":{"top_left_x":244,"top_left_y":2242,"width":1503,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"401bf1955af74aaaa126fb5015f73a7f","type":"text","conversion_output":true,"text":"Both groups could also be given oral, rectal, or intravenous paracetamol. Monitoring and","text_display":"\n\nBoth groups could also be given oral, rectal, or intravenous paracetamol. Monitoring and","confidence":1,"confidence_rate":1},{"cnt":[[245,2305],[1858,2305],[1858,2357],[245,2357]],"region":{"top_left_x":244,"top_left_y":2305,"width":1615,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23d399e0d0c94ec79e5fcc7449e67fe4","type":"text","conversion_output":true,"text":"recording were identical in both groups, with heart rate, blood pressure, oxygen saturation, and","text_display":" recording were identical in both groups, with heart rate, blood pressure, oxygen saturation, and","confidence":1,"confidence_rate":1},{"cnt":[[245,2368],[1652,2368],[1652,2419],[245,2419]],"region":{"top_left_x":244,"top_left_y":2367,"width":1409,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"870cb88146f94dd2bcef20ad68eb023c","type":"text","conversion_output":true,"text":"expired sevoflurane concentrations (where applicable) every 5 min. In both groups,","text_display":" expired sevoflurane concentrations (where applicable) every 5 min. In both groups,","confidence":0.7119140625,"confidence_rate":0.9962315842166892}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"5d26818e-2d50-4a6d-8d84-6ff93172aad9-3","page":3,"lines":[{"cnt":[[245,269],[1826,269],[1826,320],[245,320]],"region":{"top_left_x":244,"top_left_y":268,"width":1583,"height":53},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc2c45e95383494a98e45a736e2f7abc","type":"text","conversion_output":true,"text":"intraoperative serum glucose values were measured after induction, and rescue protocols for","text_display":"\nintraoperative serum glucose values were measured after induction, and rescue protocols for","confidence":1,"confidence_rate":1},{"cnt":[[245,331],[1532,331],[1532,380],[245,380]],"region":{"top_left_x":244,"top_left_y":330,"width":1288,"height":51},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6cd48ad69614fb389b049855c8e2f28","type":"text","conversion_output":true,"text":"hypoglycaemia, hypotension, and hypoxaemia were applied as appropriate.","text_display":" hypoglycaemia, hypotension, and hypoxaemia were applied as appropriate.","confidence":1,"confidence_rate":1},{"cnt":[[236,417],[438,417],[438,477],[236,477]],"region":{"top_left_x":236,"top_left_y":416,"width":203,"height":61},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59631cc480b343e5935f8e6bc2a1d660","type":"section_header","conversion_output":false,"children_ids":["f22c8677ec704203be419b6e9d853fe5"],"text":"","text_display":""},{"cnt":[[245,423],[432,423],[432,466],[245,466]],"region":{"top_left_x":244,"top_left_y":423,"width":188,"height":44},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f22c8677ec704203be419b6e9d853fe5","type":"text","conversion_output":true,"parent_id":"59631cc480b343e5935f8e6bc2a1d660","text":"Outcomes","text_display":"\n\n\\section*{Outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[245,535],[1846,535],[1846,587],[245,587]],"region":{"top_left_x":244,"top_left_y":534,"width":1602,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3d4d001739c4167b4b3e0503936309d","type":"text","conversion_output":true,"text":"The primary outcome measure was the Wechsler Preschool and Primary Scale of Intelligence,","text_display":"\n\nThe primary outcome measure was the Wechsler Preschool and Primary Scale of Intelligence,","confidence":1,"confidence_rate":1},{"cnt":[[245,597],[1755,597],[1755,647],[245,647]],"region":{"top_left_x":244,"top_left_y":597,"width":1512,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ac86e26369c4734bf3287f4a4bccaa8","type":"text","conversion_output":true,"text":"third edition (WPPSI-III) full-scale intelligence quotient (FSIQ) score. Secondary outcome","text_display":" third edition (WPPSI-III) full-scale intelligence quotient (FSIQ) score. 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The total assessment time","confidence":0.87060546875,"confidence_rate":0.9986811906962705},{"cnt":[[245,1100],[1824,1100],[1824,1147],[245,1147]],"region":{"top_left_x":244,"top_left_y":1100,"width":1581,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5c8fc0fc4d8424dacf3557eeb90eb42","type":"text","conversion_output":true,"text":"was estimated to take around 3 h to complete, and assessments were done at each site by a","text_display":" was estimated to take around 3 h to complete, and assessments were done at each site by a","confidence":0.9990234375,"confidence_rate":0.9999901309613475},{"cnt":[[245,1160],[1811,1160],[1811,1210],[245,1210]],"region":{"top_left_x":244,"top_left_y":1160,"width":1568,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3fcf8c07a65f4847828935d4ed42ee65","type":"text","conversion_output":true,"text":"child psychologist certified to conduct the tests. 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Site visits were done by the national coordinating teams for each country annually","text_display":" recruitment. 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Summary data by allocation were","text_display":" investigators from other nations to check the validity of data. Summary data by allocation were","confidence":1,"confidence_rate":1},{"cnt":[[245,2307],[733,2307],[733,2357],[245,2357]],"region":{"top_left_x":244,"top_left_y":2307,"width":489,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c76637959eca4d26ae5e5bd49392b052","type":"text","conversion_output":true,"text":"presented to this committee.","text_display":" presented to this 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herniorrhaphy.","text_display":" have received awake-regional anaesthesia or general anaesthesia for inguinal herniorrhaphy.","confidence":1,"confidence_rate":1},{"cnt":[[245,477],[1858,477],[1858,529],[245,529]],"region":{"top_left_x":244,"top_left_y":476,"width":1615,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"073444110029469da431b3508f3375a3","type":"text","conversion_output":true,"text":"Because this was an equivalence study, the outcome was analysed on an per-protocol basis to","text_display":" Because this was an equivalence study, the outcome was analysed on an per-protocol basis to","confidence":1,"confidence_rate":1},{"cnt":[[245,541],[1766,541],[1766,591],[245,591]],"region":{"top_left_x":244,"top_left_y":541,"width":1523,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1cb97f7b8674bb896d08160d1d932e1","type":"text","conversion_output":true,"text":"ensure a conservative estimate of the treatment effect in the direction of non-equivalence.","text_display":" ensure a conservative estimate of the treatment effect in the direction of non-equivalence.","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[245,604],[1760,604],[1760,655],[245,655]],"region":{"top_left_x":244,"top_left_y":603,"width":1516,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3e6d3d8be2f482894bdbc759e9f3485","type":"text","conversion_output":true,"text":"Although it is best practice to analyse outcomes on an intention-to-treat basis, there were","text_display":" Although it is best practice to analyse outcomes on an intention-to-treat basis, there 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who had some exposure to general anaesthesia, particularly if the","confidence":1,"confidence_rate":1},{"cnt":[[245,793],[1820,793],[1820,840],[245,840]],"region":{"top_left_x":244,"top_left_y":792,"width":1576,"height":49},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3210503c040943698bdf8ca699f5a13e","type":"text","conversion_output":true,"text":"awake-regional anaesthesia failed). If all infants were analysed on an intention-to-treat basis,","text_display":" awake-regional anaesthesia failed). If all infants were analysed on an intention-to-treat basis,","confidence":1,"confidence_rate":1},{"cnt":[[245,855],[1800,855],[1800,904],[245,904]],"region":{"top_left_x":244,"top_left_y":855,"width":1557,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"debdc707164b47f499db65b47183bbad","type":"text","conversion_output":true,"text":"this switching from one randomised treatment to the other could dilute the potential effect of","text_display":" this switching from one randomised treatment to the other could dilute the potential effect of","confidence":1,"confidence_rate":1},{"cnt":[[245,911],[1369,911],[1369,967],[245,967]],"region":{"top_left_x":244,"top_left_y":910,"width":1125,"height":57},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d023b0050abe4ba8b1a16369d1167040","type":"text","conversion_output":true,"text":"general anaesthesia and thus bias the trial towards equivalence. \\({ }^{22}\\)","text_display":" general anaesthesia and thus bias the trial towards equivalence. \\({ }^{22}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,1021],[1798,1021],[1798,1072],[245,1072]],"region":{"top_left_x":244,"top_left_y":1020,"width":1555,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50ff6f78e749437abc401e9567d9ef52","type":"text","conversion_output":true,"text":"Equivalence was defined a priori as the \\(95 \\% CI\\) of the difference in means of the FSIQ lying","text_display":"\n\nEquivalence was defined a priori as the \\(95 \\% CI\\) of the difference in means of the FSIQ lying","confidence":0.931124286587135,"confidence_rate":0.9992936900230235},{"cnt":[[245,1083],[1863,1083],[1863,1132],[245,1132]],"region":{"top_left_x":244,"top_left_y":1082,"width":1619,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7fdef6be2acf418c90b41e854afc7dc0","type":"text","conversion_output":true,"text":"within -5 and +5 IQ points. Intention-to-treat analyses were also planned. All Cls are two-sided.","text_display":" within -5 and +5 IQ points. Intention-to-treat analyses were also planned. All Cls are two-sided.","confidence":0.96533203125,"confidence_rate":0.9996733574057123},{"cnt":[[245,1188],[1794,1188],[1794,1235],[245,1235]],"region":{"top_left_x":244,"top_left_y":1188,"width":1550,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19e05277087040eaa42c48660a884ad6","type":"text","conversion_output":true,"text":"The sample size was based on the primary outcome. Assuming an expected difference of 1","text_display":"\n\nThe sample size was based on the primary outcome. Assuming an expected difference of 1","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[245,1250],[1772,1250],[1772,1300],[245,1300]],"region":{"top_left_x":244,"top_left_y":1250,"width":1529,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e30c59d2678840ef992b7c17ff203839","type":"text","conversion_output":true,"text":"standardised score point, a standard deviation of 15 , and a \\(90 \\%\\) chance that a \\(95 \\% CI\\) will","text_display":" standardised score point, a standard deviation of 15 , and a \\(90 \\%\\) chance that a \\(95 \\% CI\\) will","confidence":0.5131009700708091,"confidence_rate":0.9937246535952409},{"cnt":[[245,1315],[1687,1315],[1687,1362],[245,1362]],"region":{"top_left_x":244,"top_left_y":1314,"width":1443,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2d7104efd6649aca08a9367b8a660b4","type":"text","conversion_output":true,"text":"exclude a difference of more than 5 points (the largest difference acceptable to show","text_display":" exclude a difference of more than 5 points (the largest difference acceptable to show","confidence":0.9873046875,"confidence_rate":0.9998626267851773},{"cnt":[[245,1375],[1798,1375],[1798,1424],[245,1424]],"region":{"top_left_x":244,"top_left_y":1375,"width":1555,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6469e5c22f864be3bb9bbc8e0b8b310a","type":"text","conversion_output":true,"text":"equivalence), the trial would need 598 infants. The sample size formula used was based on","text_display":" equivalence), the trial would need 598 infants. The sample size formula used was based on","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[1824,1439],[1824,1489],[245,1489]],"region":{"top_left_x":244,"top_left_y":1439,"width":1581,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c79117e0c63e4515968640ab532a3704","type":"text","conversion_output":true,"text":"approximations to the normal distribution, and used a two one-sided test procedure. Enrolling","text_display":" approximations to the normal distribution, and used a two one-sided test procedure. Enrolling","confidence":0.9990236759185791,"confidence_rate":0.9999900326925697},{"cnt":[[245,1500],[1820,1500],[1820,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1499,"width":1576,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a112f4e0209e46de89a745e479128180","type":"text","conversion_output":true,"text":"roughly 720 participants would allow for \\(10 \\%\\) loss to follow-up and \\(10 \\%\\) with a major protocol","text_display":" roughly 720 participants would allow for \\(10 \\%\\) loss to follow-up and \\(10 \\%\\) with a major protocol","confidence":0.9843893051147461,"confidence_rate":0.9998515787052127},{"cnt":[[245,1564],[402,1564],[402,1605],[245,1605]],"region":{"top_left_x":244,"top_left_y":1564,"width":158,"height":41},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ea4d07658cd449fa5c24f78a5d61f79","type":"text","conversion_output":true,"text":"violation.","text_display":" violation.","confidence":1,"confidence_rate":1},{"cnt":[[245,1667],[1867,1667],[1867,1717],[245,1717]],"region":{"top_left_x":244,"top_left_y":1667,"width":1623,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69bc77cfa3b849a49ffbc1e3b73bc8e9","type":"text","conversion_output":true,"text":"We used multiple imputation under a multivariate normal distribution to impute missing outcome","text_display":"\n\nWe used multiple imputation under a multivariate normal distribution to impute missing outcome","confidence":1,"confidence_rate":1},{"cnt":[[245,1729],[1828,1729],[1828,1777],[245,1777]],"region":{"top_left_x":244,"top_left_y":1729,"width":1585,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fed5fd07de3c44409912135d666c4646","type":"text","conversion_output":true,"text":"data in the primary analysis of all outcomes, with a sensitivity analysis done on only complete","text_display":" data in the primary analysis of all outcomes, with a sensitivity analysis done on only complete","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1876,1792],[1876,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1791,"width":1632,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c075b9a231c4712b35497f83e2f3878","type":"text","conversion_output":true,"text":"cases. Multiple imputations were done with the mi impute mvn statement in Stata (version 14.2).","text_display":" cases. Multiple imputations were done with the mi impute mvn statement in Stata (version 14.2).","confidence":0.994140625,"confidence_rate":0.9999412356418027},{"cnt":[[245,1852],[1852,1852],[1852,1901],[245,1901]],"region":{"top_left_x":244,"top_left_y":1851,"width":1608,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d781a39a8c64c0da7f3c7c72bf84ee7","type":"text","conversion_output":true,"text":"The variables used in the multiple imputation models included baseline, post-randomisation, 2-","text_display":" The variables used in the multiple imputation models included baseline, post-randomisation, 2","confidence":0.94482421875,"confidence_rate":0.9994268675284941},{"cnt":[[245,1916],[1790,1916],[1790,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1916,"width":1546,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c076910af45946e28c7f38ddad6c0452","type":"text","conversion_output":true,"text":"year cognitive variables, and 5 -year outcome variables. A number of prespecified variables","text_display":"year cognitive variables, and 5 -year outcome variables. A number of prespecified variables","confidence":1,"confidence_rate":1},{"cnt":[[245,1981],[1807,1979],[1807,2028],[245,2030]],"region":{"top_left_x":244,"top_left_y":1978,"width":1563,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06874abcc5d5479f9e7812737821a48f","type":"text","conversion_output":true,"text":"were used as possible predictor variables within the imputation approach, including baseline","text_display":" were used as possible predictor variables within the imputation approach, including baseline","confidence":1,"confidence_rate":1},{"cnt":[[245,2041],[1766,2041],[1766,2090],[245,2090]],"region":{"top_left_x":244,"top_left_y":2041,"width":1523,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53fcc33457d3433f84b2f38b35fafc5f","type":"text","conversion_output":true,"text":"variables (anaesthesia group, country, sex, gestational age at birth, birthweight, antenatal","text_display":" variables (anaesthesia group, country, sex, gestational age at birth, birthweight, antenatal","confidence":1,"confidence_rate":1},{"cnt":[[245,2105],[1794,2105],[1794,2153],[245,2153]],"region":{"top_left_x":244,"top_left_y":2105,"width":1550,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af06447af70c48adb35dc6f0f0eb1bbb","type":"text","conversion_output":true,"text":"steroids received by mother, mother's education, and maternal age \\(<21\\) years), variables at","text_display":" steroids received by mother, mother's education, and maternal age \\(<21\\) years), variables at","confidence":0.9853515625,"confidence_rate":0.9998494318952309},{"cnt":[[245,2168],[1768,2168],[1768,2215],[245,2215]],"region":{"top_left_x":244,"top_left_y":2167,"width":1525,"height":49},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"299abc4464c74474b699b79edc040347","type":"text","conversion_output":true,"text":"surgery (need for fluid bolus for hypotension, duration of surgery, significant postoperative","text_display":" surgery (need for fluid bolus for hypotension, duration of surgery, significant postoperative","confidence":1,"confidence_rate":1},{"cnt":[[245,2230],[1841,2230],[1841,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2230,"width":1598,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f9fb9e940c1f40f5a851e3fdea7e9c03","type":"text","conversion_output":true,"text":"apnoea, and age), variables at age 2 years (composite cognitive, language, motor and social-","text_display":" apnoea, and age), variables at age 2 years (composite cognitive, language, motor and social","confidence":1,"confidence_rate":1},{"cnt":[[245,2292],[1794,2292],[1794,2340],[245,2340]],"region":{"top_left_x":244,"top_left_y":2292,"width":1550,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"79219a65a20c449c99e73cb2fca8096d","type":"text","conversion_output":true,"text":"emotional score on the Bayley Scales of Infant and Toddler Development, third edition; any","text_display":"emotional score on the Bayley Scales of Infant and Toddler Development, third edition; any","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,2355],[1729,2355],[1729,2402],[245,2402]],"region":{"top_left_x":244,"top_left_y":2354,"width":1486,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"307e1d99d75e43d5887c5f2cecfabe8d","type":"text","conversion_output":true,"text":"additional anaesthetic exposures since the inguinal herniorrhaphy; any interventions for","text_display":" additional anaesthetic exposures since the inguinal herniorrhaphy; any interventions for","confidence":1,"confidence_rate":1},{"cnt":[[245,2419],[1858,2419],[1858,2466],[245,2466]],"region":{"top_left_x":244,"top_left_y":2419,"width":1615,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"693d149f447f42b98846c494128e8c61","type":"text","conversion_output":true,"text":"neurodevelopmental problems; and any other neurological abnormality), and variables at age 5","text_display":" neurodevelopmental problems; and any other neurological abnormality), and variables at age 5","confidence":0.9990236759185791,"confidence_rate":0.999989825041388}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"5d26818e-2d50-4a6d-8d84-6ff93172aad9-5","page":5,"lines":[{"cnt":[[243,266],[1790,266],[1790,320],[243,320]],"region":{"top_left_x":242,"top_left_y":266,"width":1548,"height":55},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1b410166df24478af1f3535946516c9","type":"text","conversion_output":true,"text":"years (WPPSI-III FSIQ, any chronic illness, any additional anaesthetic exposures since the","text_display":"\nyears (WPPSI-III FSIQ, any chronic illness, any additional anaesthetic exposures since the","confidence":1,"confidence_rate":1},{"cnt":[[243,329],[1704,329],[1704,382],[243,382]],"region":{"top_left_x":242,"top_left_y":328,"width":1462,"height":55},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56b125ae4ab143ce9f66742a76f88611","type":"text","conversion_output":true,"text":"inguinal herniorrhaphy, total length of any readmission to hospital, cerebral palsy, any","text_display":" inguinal herniorrhaphy, total length of any readmission to hospital, cerebral palsy, any","confidence":1,"confidence_rate":1},{"cnt":[[243,391],[1865,391],[1865,445],[243,445]],"region":{"top_left_x":242,"top_left_y":391,"width":1623,"height":54},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f93ee2521c145599ea188c9929860ac","type":"text","conversion_output":true,"text":"interventions for neurodevelopmental problems, and any other neurological abnormality). Since","text_display":" interventions for neurodevelopmental problems, and any other neurological abnormality). Since","confidence":1,"confidence_rate":1},{"cnt":[[245,451],[1858,451],[1858,507],[245,507]],"region":{"top_left_x":244,"top_left_y":451,"width":1615,"height":57},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c63dab942774d73b256cb9f6bab4882","type":"text","conversion_output":true,"text":"most of these variables also have missingness, they were also imputed where necessary. With","text_display":" most of these variables also have missingness, they were also imputed where necessary. With","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1876,516],[1876,569],[245,569]],"region":{"top_left_x":244,"top_left_y":515,"width":1632,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"710e824f08ed4c1db2c1a9df90d57523","type":"text","conversion_output":true,"text":"many missing observations, these multiple imputation models did not always converge, in which","text_display":" many missing observations, these multiple imputation models did not always converge, in which","confidence":1,"confidence_rate":1},{"cnt":[[245,578],[1846,578],[1846,632],[245,632]],"region":{"top_left_x":244,"top_left_y":577,"width":1602,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3cd9bb43bb9a48fd92d5c3239b022b33","type":"text","conversion_output":true,"text":"case, to ensure convergence of models, applicable variables were not included. The variables","text_display":" case, to ensure convergence of models, applicable variables were not included. The variables","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,640],[1515,640],[1515,694],[245,694]],"region":{"top_left_x":244,"top_left_y":640,"width":1271,"height":54},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ebf0d717f1db40b3ae6796d705a7fa5f","type":"text","conversion_output":true,"text":"used in the analysis model were always included in the imputation models.","text_display":" used in the analysis model were always included in the imputation models.","confidence":1,"confidence_rate":1},{"cnt":[[245,743],[1841,743],[1841,801],[245,801]],"region":{"top_left_x":244,"top_left_y":743,"width":1598,"height":59},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"821f37de85b0465a8ce6a1213ca52ffc","type":"text","conversion_output":true,"text":"For all continuous outcomes, linear regression was used with the factor variables anaesthesia","text_display":"\n\nFor all continuous outcomes, linear regression was used with the factor variables anaesthesia","confidence":1,"confidence_rate":1},{"cnt":[[245,808],[1858,808],[1858,862],[245,862]],"region":{"top_left_x":244,"top_left_y":807,"width":1615,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a529e0bc23541029bef5f32b2196a74","type":"text","conversion_output":true,"text":"group (awake-regional anaesthesia and general anaesthesia), with gestational age at birth and","text_display":" group (awake-regional anaesthesia and general anaesthesia), with gestational age at birth and","confidence":1,"confidence_rate":1},{"cnt":[[245,870],[1611,870],[1611,924],[245,924]],"region":{"top_left_x":244,"top_left_y":870,"width":1368,"height":54},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b5ca171184f4a118e52dcb35262ba44","type":"text","conversion_output":true,"text":"country as fixed effects. Adjusted mean differences are presented with \\(95 \\%\\) Cls.","text_display":" country as fixed effects. Adjusted mean differences are presented with \\(95 \\%\\) Cls.","confidence":0.783091330435127,"confidence_rate":0.9971935323174168},{"cnt":[[243,975],[1858,975],[1858,1029],[243,1029]],"region":{"top_left_x":242,"top_left_y":975,"width":1617,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa58927d616f48189a139aa281d12e79","type":"text","conversion_output":true,"text":"All binary outcomes were analysed with generalised linear models with binomial link function to","text_display":"\n\nAll binary outcomes were analysed with generalised linear models with binomial link function to","confidence":1,"confidence_rate":1},{"cnt":[[245,1036],[1858,1036],[1858,1091],[245,1091]],"region":{"top_left_x":244,"top_left_y":1035,"width":1615,"height":57},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c93640bc24b4a198a3dd9ceab8a8d13","type":"text","conversion_output":true,"text":"enable estimation of risk ratios, adjusting for the same factors as for the linear regression. Risk","text_display":" enable estimation of risk ratios, adjusting for the same factors as for the linear regression. Risk","confidence":1,"confidence_rate":1},{"cnt":[[245,1100],[840,1100],[840,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1100,"width":597,"height":54},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"053a5241bf724c8cae51f705c64fb415","type":"text","conversion_output":true,"text":"ratios are presented with 95\\% Cls.","text_display":" ratios are presented with 95\\% Cls.","confidence":0.39426684379577637,"confidence_rate":0.9764177092440672},{"cnt":[[245,1203],[1783,1203],[1783,1257],[245,1257]],"region":{"top_left_x":244,"top_left_y":1203,"width":1540,"height":54},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ab1ac211ead4e81aa8085ca82570832","type":"text","conversion_output":true,"text":"The following subgroup analyses were prespecified in the statistical analysis plan: country,","text_display":"\n\nThe following subgroup analyses were prespecified in the statistical analysis plan: country,","confidence":1,"confidence_rate":1},{"cnt":[[245,1265],[1777,1265],[1777,1321],[245,1321]],"region":{"top_left_x":244,"top_left_y":1265,"width":1533,"height":57},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d2cf5974e424dbf9899365c104d13b4","type":"text","conversion_output":true,"text":"duration of surgery ( \\(\\geq 120 min\\) or \\(<120 min\\) ), and age at surgery ( \\(>70\\) days or \\(\\leq 70\\) days). A","text_display":" duration of surgery ( \\(\\geq 120 min\\) or \\(<120 min\\) ), and age at surgery ( \\(>70\\) days or \\(\\leq 70\\) days). A","confidence":0.9535840117455336,"confidence_rate":0.9995757351238598},{"cnt":[[245,1328],[1852,1328],[1852,1381],[245,1381]],"region":{"top_left_x":244,"top_left_y":1327,"width":1608,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99b1a5beb7f845458f8c3e06f3289ef4","type":"text","conversion_output":true,"text":"subgroup analysis by ex-term versus ex-preterm (born at \\(<37\\) weeks' gestation) was also done","text_display":" subgroup analysis by ex-term versus ex-preterm (born at \\(<37\\) weeks' gestation) was also done","confidence":0.54248046875,"confidence_rate":0.9938412333669977},{"cnt":[[245,1392],[1880,1392],[1880,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1392,"width":1636,"height":54},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b3c5d5ab77f4f7db0400d1d97a98f75","type":"text","conversion_output":true,"text":"post hoc. \\(p\\) values for the interactions are shown along with subgroup treatment effect estimates","text_display":" post hoc. \\(p\\) values for the interactions are shown along with subgroup treatment effect estimates","confidence":0.7265146663412452,"confidence_rate":0.9969326312436603},{"cnt":[[245,1452],[1283,1452],[1283,1506],[245,1506]],"region":{"top_left_x":244,"top_left_y":1452,"width":1039,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4558c7109a7442c59de30e5064cadf95","type":"text","conversion_output":true,"text":"and \\(95 \\%\\) Cls. All analyses were done in Stata (version 14.2).","text_display":" and \\(95 \\%\\) Cls. All analyses were done in Stata (version 14.2).","confidence":0.9570722579956055,"confidence_rate":0.9993549671572759},{"cnt":[[245,1560],[1579,1560],[1579,1611],[245,1611]],"region":{"top_left_x":244,"top_left_y":1559,"width":1336,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b19793bd8ec24ccd932680f65d53463c","type":"text","conversion_output":true,"text":"The GAS trial is registered in Australia and New Zealand at ANZCTR (number","text_display":"\n\nThe GAS trial is registered in Australia and New Zealand at ANZCTR (number","confidence":1,"confidence_rate":1},{"cnt":[[243,1620],[1738,1620],[1738,1674],[243,1674]],"region":{"top_left_x":242,"top_left_y":1619,"width":1497,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0563d8f3cdea4debbc0213baaccc01f1","type":"text","conversion_output":true,"text":"ACTRN12606000441516, first registered Oct 16, 2006); in the USA at ClinicalTrials.gov","text_display":" ACTRN12606000441516, first registered Oct 16, 2006); in the USA at ClinicalTrials.gov","confidence":0.9990236759185791,"confidence_rate":0.9999891467144949},{"cnt":[[245,1684],[1729,1684],[1729,1738],[245,1738]],"region":{"top_left_x":244,"top_left_y":1684,"width":1486,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1fda85d8479f4c18bcd427264ec47d3e","type":"text","conversion_output":true,"text":"(number NCT00756600, first registered on Sept 18, 2008); and in the UK at UK Clinical","text_display":" (number NCT00756600, first registered on Sept 18, 2008); and in the UK at UK Clinical","confidence":1,"confidence_rate":1},{"cnt":[[245,1745],[1815,1745],[1815,1798],[245,1798]],"region":{"top_left_x":244,"top_left_y":1744,"width":1572,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"773dfc0b9a224780bf2f587027b659c0","type":"text","conversion_output":true,"text":"Research Network (number 6635; ISRCTN ID 12437565; MREC number 07/S0709/20). The","text_display":" Research Network (number 6635; ISRCTN ID 12437565; MREC number 07/S0709/20). The","confidence":1,"confidence_rate":1},{"cnt":[[245,1800],[1697,1800],[1697,1863],[245,1863]],"region":{"top_left_x":244,"top_left_y":1800,"width":1454,"height":63},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1732ddd7b814b78b21cc6ce917fa110","type":"text","conversion_output":true,"text":"statistical analysis plan is available at ANZCTR (number ACTRN12606000441516). \\({ }^{23}\\)","text_display":" statistical analysis plan is available at ANZCTR (number ACTRN12606000441516). \\({ }^{23}\\)","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]}]}