Add files using upload-large-folder tool

documents/10.1056_nejmoa1800566/DEDUP_NOTE.md

@@ -0,0 +1,3 @@
+# Identical source PDFs
+
+`protocol.pdf` and `sap.pdf` in this folder are **byte-identical** (sha256 `b5e65846952e30947ed1c3fddf42b59bd1379867ccd7a75fa2adb8522fcfa297`).

documents/10.1056_nejmoa1800781/DEDUP_NOTE.md

@@ -0,0 +1,3 @@
+# Identical source PDFs
+
+`protocol.pdf` and `sap.pdf` in this folder are **byte-identical** (sha256 `94218aec226eb3335ca659c291d9b0878838735addafb2fde6b8345fe991f753`).

documents/10.1056_nejmoa1800965/DEDUP_NOTE.md

@@ -0,0 +1,3 @@
+# Identical source PDFs
+
+`protocol.pdf` and `sap.pdf` in this folder are **byte-identical** (sha256 `daeb65978aa78997cf4bd74881abb8f27b7506ba180228d2b955cdbbd8b1d1bb`).

documents/10.1056_nejmoa1801601/sap.lines.json

@@ -0,0 +1 @@
+{"pages":[{"image_id":"8501b684-3e70-49a9-81f9-ab3940fd1a00-1","page":1,"lines":[{"cnt":[[915,316],[1199,316],[1199,703],[915,703]],"region":{"top_left_x":915,"top_left_y":315,"width":284,"height":388},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba66f06a5d8d45d4b56d671038bcdf16","type":"diagram","conversion_output":false,"text":"","text_display":"","subtype":"logo"},{"cnt":[[967,552],[1147,552],[1147,591],[967,591]],"region":{"top_left_x":966,"top_left_y":552,"width":182,"height":39},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0f7d721afc14bed8b88ff8289c610df","type":"text","conversion_output":true,"text":"RELIEF","text_display":"RELIEF","confidence":0.99853515625,"confidence_rate":0.9998667436355548},{"cnt":[[881,885],[1235,885],[1235,937],[881,937]],"region":{"top_left_x":880,"top_left_y":885,"width":356,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c8f0731599b4d2c9dc2d7a3a905bf77","type":"section_header","conversion_output":false,"children_ids":["ba411b59f9fd4b048ef2c076b55db52f"],"text":"","text_display":""},{"cnt":[[885,889],[1231,889],[1231,935],[885,935]],"region":{"top_left_x":885,"top_left_y":889,"width":347,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba411b59f9fd4b048ef2c076b55db52f","type":"text","conversion_output":true,"parent_id":"0c8f0731599b4d2c9dc2d7a3a905bf77","text":"The RELIEF Trial","text_display":"\n\n\\section*{The RELIEF Trial}","confidence":0.99951171875,"confidence_rate":0.9999767431038692},{"cnt":[[503,993],[1618,993],[1618,1042],[503,1042]],"region":{"top_left_x":502,"top_left_y":992,"width":1116,"height":50},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7599669b1e894d2389a6446bc740c68b","type":"section_header","conversion_output":false,"children_ids":["1955ab5fcbd04a7b886b9f853460a801"],"text":"","text_display":""},{"cnt":[[507,997],[1618,997],[1618,1038],[507,1038]],"region":{"top_left_x":507,"top_left_y":996,"width":1111,"height":42},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1955ab5fcbd04a7b886b9f853460a801","type":"text","conversion_output":true,"parent_id":"7599669b1e894d2389a6446bc740c68b","text":"REstrictive versus LIbEral Fluid Therapy in Major Abdominal Surgery","text_display":"\n\n\\section*{REstrictive versus LIbEral Fluid Therapy in Major Abdominal Surgery}","confidence":0.943082831047036,"confidence_rate":0.999186426097464},{"cnt":[[907,1160],[1218,1160],[1218,1210],[907,1210]],"region":{"top_left_x":906,"top_left_y":1160,"width":313,"height":50},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c71e68355a604cec83abab7f5fbf0fdb","type":"section_header","conversion_output":false,"children_ids":["f94bbe0db08d4dba9c172e9a31e1cb1f"],"text":"","text_display":""},{"cnt":[[911,1164],[1214,1164],[1214,1205],[911,1205]],"region":{"top_left_x":910,"top_left_y":1164,"width":304,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f94bbe0db08d4dba9c172e9a31e1cb1f","type":"text","conversion_output":true,"parent_id":"c71e68355a604cec83abab7f5fbf0fdb","text":"www.relief.org.au","text_display":"\n\n\\section*{www.relief.org.au}","confidence":1,"confidence_rate":1},{"cnt":[[226,1369],[1893,1369],[1893,1405],[226,1405]],"region":{"top_left_x":225,"top_left_y":1368,"width":1668,"height":38},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f8382b928774d8b82c009cc1d199afb","type":"text","conversion_output":true,"text":"On behalf of the Australian and New Zealand College of Anaesthetists Clinical Trials Network (ANZCA CTN), and the Australian","text_display":"\n\nOn behalf of the Australian and New Zealand College of Anaesthetists Clinical Trials Network (ANZCA CTN), and the Australian","confidence":0.99951171875,"confidence_rate":0.9999962139567942},{"cnt":[[563,1409],[1553,1409],[1553,1446],[563,1446]],"region":{"top_left_x":562,"top_left_y":1409,"width":992,"height":37},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59c148584ae644f6997e6fbfcc733d15","type":"text","conversion_output":true,"text":"and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG)","text_display":" and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG)","confidence":0.9970703125,"confidence_rate":0.9999623854839207},{"cnt":[[1246,1568],[1803,1568],[1803,1605],[1246,1605]],"region":{"top_left_x":1246,"top_left_y":1568,"width":557,"height":37},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"077517dbf3b143818e8bf3025bb00a42","type":"text","conversion_output":true,"text":"ClinicalTrials.gov Identifier: NCT01424150","text_display":"\n\nClinicalTrials.gov Identifier: NCT01424150","confidence":0.9980478286743164,"confidence_rate":0.9999584247090497},{"cnt":[[1517,1766],[1803,1766],[1803,1803],[1517,1803]],"region":{"top_left_x":1516,"top_left_y":1766,"width":287,"height":37},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6b81e49d8bb4427baa89789d9a63178","type":"text","conversion_output":true,"text":"SAP August 29, 2017","text_display":"\n\nSAP August 29, 2017","confidence":1,"confidence_rate":1},{"cnt":[[322,2127],[1354,2127],[1354,2163],[322,2163]],"region":{"top_left_x":322,"top_left_y":2126,"width":1032,"height":38},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67df70420de04c8a91d0f2ab7bb3941f","type":"text","conversion_output":true,"text":"Study title: Restrictive versus liberal fluid therapy in major abdominal surgery","text_display":"\n\nStudy title: Restrictive versus liberal fluid therapy in major abdominal surgery","confidence":0.9980475902557373,"confidence_rate":0.9999770082857181},{"cnt":[[322,2209],[922,2209],[922,2241],[322,2241]],"region":{"top_left_x":322,"top_left_y":2208,"width":600,"height":33},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25b53c1a0d3d4106b7ac3eaa63553bad","type":"text","conversion_output":true,"text":"Protocol Number: Anaesthesia Research 046","text_display":"\n\nProtocol Number: Anaesthesia Research 046","confidence":0.99609375,"confidence_rate":0.999913028241793},{"cnt":[[322,2286],[793,2286],[793,2322],[322,2322]],"region":{"top_left_x":322,"top_left_y":2285,"width":471,"height":38},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e46790e4cd544e63a57b9ed19017ee60","type":"text","conversion_output":true,"text":"Sponsor: Alfred Health, Melbourne","text_display":"\n\nSponsor: Alfred Health, Melbourne","confidence":1,"confidence_rate":1},{"cnt":[[322,2406],[1553,2406],[1553,2443],[322,2443]],"region":{"top_left_x":322,"top_left_y":2406,"width":1232,"height":37},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b29abd347574808b7b93b529c951e3e","type":"text","conversion_output":true,"text":"Funding source: The Australian National Health and Medical Research Council (APP1043755)","text_display":"\n\nFunding source: The Australian National Health and Medical Research Council (APP1043755)","confidence":0.99853515625,"confidence_rate":0.9999842375685026}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"8501b684-3e70-49a9-81f9-ab3940fd1a00-2","page":2,"lines":[{"cnt":[[318,320],[1072,320],[1072,389],[318,389]],"region":{"top_left_x":317,"top_left_y":320,"width":756,"height":69},"line":1,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"8f48cd1ad3684c57ad9a90f9aa103b81","type":"title","conversion_output":false,"children_ids":["f4b708fe155840aead50bacf80ff4563"],"text":"","text_display":""},{"cnt":[[322,322],[1068,322],[1068,385],[322,385]],"region":{"top_left_x":322,"top_left_y":322,"width":746,"height":63},"line":2,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"f4b708fe155840aead50bacf80ff4563","type":"text","conversion_output":true,"parent_id":"8f48cd1ad3684c57ad9a90f9aa103b81","text":"RELIEF Statistical Analysis Plan","text_display":"\n\n\\title{\nRELIEF Statistical Analysis Plan\n}","confidence":0.9912302363691197,"confidence_rate":0.9997619622727466},{"cnt":[[318,391],[591,391],[591,436],[318,436]],"region":{"top_left_x":317,"top_left_y":391,"width":274,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0179a09d71924dba96a3c09a4e3e1d26","type":"section_header","conversion_output":false,"children_ids":["1b07ce4208f248f9896ed95ac9a2d9e5"],"text":"","text_display":""},{"cnt":[[322,391],[589,391],[589,436],[322,436]],"region":{"top_left_x":322,"top_left_y":391,"width":267,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b07ce4208f248f9896ed95ac9a2d9e5","type":"text","conversion_output":true,"parent_id":"0179a09d71924dba96a3c09a4e3e1d26","text":"August 29, 2017","text_display":"\n\n\\section*{August 29, 2017}","confidence":1,"confidence_rate":1},{"cnt":[[322,438],[1738,438],[1738,483],[322,483]],"region":{"top_left_x":322,"top_left_y":438,"width":1417,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c1502bbdf6746c39cf739673f27815b","type":"text","conversion_output":true,"text":"We will apply the intention to treat principle, analysing all participants who are enrolled,","text_display":"\n\nWe will apply the intention to treat principle, analysing all participants who are enrolled,","confidence":1,"confidence_rate":1},{"cnt":[[322,486],[1772,486],[1772,531],[322,531]],"region":{"top_left_x":322,"top_left_y":485,"width":1451,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"515db0dd3ad7479ea606fba47dac6990","type":"text","conversion_output":true,"text":"randomised and undergo induction of general anaesthesia for eligible surgery. Patients are","text_display":" randomised and undergo induction of general anaesthesia for eligible surgery. Patients are","confidence":1,"confidence_rate":1},{"cnt":[[322,533],[1755,533],[1755,578],[322,578]],"region":{"top_left_x":322,"top_left_y":532,"width":1434,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae0ce380631248d9a1d69dd33854b572","type":"text","conversion_output":true,"text":"followed for the duration of the trial, unless they withdraw consent, for which we will use","text_display":" followed for the duration of the trial, unless they withdraw consent, for which we will use","confidence":1,"confidence_rate":1},{"cnt":[[322,580],[1175,580],[1175,625],[322,625]],"region":{"top_left_x":322,"top_left_y":580,"width":854,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c07ec08e72134c81ae83fca0e7bc7536","type":"text","conversion_output":true,"text":"their data up until the time of withdrawal of consent.","text_display":" their data up until the time of withdrawal of consent.","confidence":1,"confidence_rate":1},{"cnt":[[318,629],[788,629],[788,677],[318,677]],"region":{"top_left_x":317,"top_left_y":629,"width":472,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb91573c321440cc80cfcaeebdec4832","type":"section_header","conversion_output":false,"children_ids":["75eb3799abd0457190817520fae2d756"],"text":"","text_display":""},{"cnt":[[322,632],[784,632],[784,677],[322,677]],"region":{"top_left_x":322,"top_left_y":631,"width":463,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75eb3799abd0457190817520fae2d756","type":"text","conversion_output":true,"parent_id":"bb91573c321440cc80cfcaeebdec4832","text":"ENDPOINT DEFINITIONS","text_display":"\n\n\\section*{ENDPOINT DEFINITIONS}","confidence":1,"confidence_rate":1},{"cnt":[[318,683],[621,683],[621,733],[318,733]],"region":{"top_left_x":317,"top_left_y":683,"width":304,"height":50},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"388dbe2deecb4814ab5429a8c082ec79","type":"section_header","conversion_output":false,"children_ids":["720805cac4ff420ca22a88cf7add223c"],"text":"","text_display":""},{"cnt":[[322,688],[617,688],[617,730],[322,730]],"region":{"top_left_x":322,"top_left_y":687,"width":295,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"720805cac4ff420ca22a88cf7add223c","type":"text","conversion_output":true,"parent_id":"388dbe2deecb4814ab5429a8c082ec79","text":"Primary endpoint","text_display":"\n\n\\section*{Primary endpoint}","confidence":1,"confidence_rate":1},{"cnt":[[320,735],[1779,735],[1779,780],[320,780]],"region":{"top_left_x":320,"top_left_y":734,"width":1459,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a6dd57f48324abfa0078c5ccad9ba61","type":"text","conversion_output":true,"text":"The primary end point of the trial is disability-free survival at 1 year after surgery. Disability","text_display":"\n\nThe primary end point of the trial is disability-free survival at 1 year after surgery. Disability","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[322,782],[1751,782],[1751,827],[322,827]],"region":{"top_left_x":322,"top_left_y":782,"width":1429,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb3f0d21a89e460eae3c5edf117e67c2","type":"text","conversion_output":true,"text":"is defined as a persistent (at least 6 months) impairment in health status, as measured by","text_display":" is defined as a persistent (at least 6 months) impairment in health status, as measured by","confidence":0.9965856064809486,"confidence_rate":0.9999651002430606},{"cnt":[[320,829],[1725,829],[1725,874],[320,874]],"region":{"top_left_x":320,"top_left_y":829,"width":1406,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0801a64084d47f18fdbbbb7beb622eb","type":"text","conversion_output":true,"text":"the \\(1 2\\)-item WHODAS score, of at least 24 points when using response scores of \\(1 - 5\\) for","text_display":" the \\(1 2\\)-item WHODAS score, of at least 24 points when using response scores of \\(1 - 5\\) for","confidence":0.40443290923028846,"confidence_rate":0.991496087054226},{"cnt":[[322,877],[1794,877],[1794,922],[322,922]],"region":{"top_left_x":322,"top_left_y":876,"width":1472,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06814dda8413466eae70aba98af4aa04","type":"text","conversion_output":true,"text":"each item, reflecting a disability level of at least \\(25 \\%\\) and being the threshold point between","text_display":" each item, reflecting a disability level of at least \\(25 \\%\\) and being the threshold point between","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[322,924],[1646,924],[1646,971],[322,971]],"region":{"top_left_x":322,"top_left_y":923,"width":1324,"height":49},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"154574bc1efe49b5abff2d7b680a4d4c","type":"text","conversion_output":true,"text":"'disabled' and 'not disabled' as per WHO guidelines. If a single item is missing at an","text_display":" 'disabled' and 'not disabled' as per WHO guidelines. If a single item is missing at an","confidence":1,"confidence_rate":1},{"cnt":[[322,971],[1764,971],[1764,1018],[322,1018]],"region":{"top_left_x":322,"top_left_y":971,"width":1442,"height":48},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81a65caf610e492ba3eea3b3ccfe8518","type":"text","conversion_output":true,"text":"assessment, the mean value of the remaining items will be assigned to the missing item. If","text_display":" assessment, the mean value of the remaining items will be assigned to the missing item. If","confidence":1,"confidence_rate":1},{"cnt":[[322,1021],[1644,1021],[1644,1068],[322,1068]],"region":{"top_left_x":322,"top_left_y":1020,"width":1322,"height":48},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90e3f15bb88e43bd86d3192575f93ad7","type":"text","conversion_output":true,"text":"more than one item is missing the score will not be calculated for that assessment.","text_display":" more than one item is missing the score will not be calculated for that assessment.","confidence":1,"confidence_rate":1},{"cnt":[[320,1068],[1781,1068],[1781,1115],[320,1115]],"region":{"top_left_x":320,"top_left_y":1067,"width":1462,"height":49},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5be43f25daa14e4195116b0c6d6a1174","type":"text","conversion_output":true,"text":"With WHODAS assessments being made at (baseline and) 30 days, 3 months, 6 months and","text_display":" With WHODAS assessments being made at (baseline and) 30 days, 3 months, 6 months and","confidence":1,"confidence_rate":1},{"cnt":[[322,1117],[1652,1117],[1652,1162],[322,1162]],"region":{"top_left_x":322,"top_left_y":1117,"width":1331,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7d54845aa124037b8cc75ca3fdfeef3","type":"text","conversion_output":true,"text":"12 months, post-operative disability that persists for at least 6 months is able to be","text_display":" 12 months, post-operative disability that persists for at least 6 months is able to be","confidence":0.97509765625,"confidence_rate":0.999728879203505},{"cnt":[[322,1164],[1745,1164],[1745,1210],[322,1210]],"region":{"top_left_x":322,"top_left_y":1164,"width":1423,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d2e78da883df4d9ea74bae316dbe1487","type":"text","conversion_output":true,"text":"observed to be commencing at the 30 day assessment, the 3 month assessment, or the 6","text_display":" observed to be commencing at the 30 day assessment, the 3 month assessment, or the 6","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[322,1212],[1790,1212],[1790,1257],[322,1257]],"region":{"top_left_x":322,"top_left_y":1211,"width":1468,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b920fda65a1442008e8356b10a04fd8d","type":"text","conversion_output":true,"text":"month assessment. For example, persistent disability commencing at 3 months requires the","text_display":" month assessment. For example, persistent disability commencing at 3 months requires the","confidence":0.9990234375,"confidence_rate":0.999989822555459},{"cnt":[[322,1259],[1747,1259],[1747,1304],[322,1304]],"region":{"top_left_x":322,"top_left_y":1258,"width":1425,"height":47},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b93a39df3be488ab10b16eac892af8c","type":"text","conversion_output":true,"text":"initial observation of disability (WHODAS >=24) at 3 months which is sustained at each of","text_display":" initial observation of disability (WHODAS >=24) at 3 months which is sustained at each of","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[320,1308],[1745,1308],[1745,1354],[320,1354]],"region":{"top_left_x":320,"top_left_y":1308,"width":1425,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b74b9f04f1f44d7a03929a75278e764","type":"text","conversion_output":true,"text":"the 6 and 12 month assessments. Missing WHODAS assessments in patients known to be","text_display":" the 6 and 12 month assessments. Missing WHODAS assessments in patients known to be","confidence":1,"confidence_rate":1},{"cnt":[[322,1354],[1618,1354],[1618,1403],[322,1403]],"region":{"top_left_x":322,"top_left_y":1353,"width":1296,"height":50},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59a3000393884f66be13fb0af5bb56ed","type":"text","conversion_output":true,"text":"alive will not be imputed in the primary analysis. Persistent disability observed to","text_display":" alive will not be imputed in the primary analysis. Persistent disability observed to","confidence":1,"confidence_rate":1},{"cnt":[[322,1403],[1747,1403],[1747,1450],[322,1450]],"region":{"top_left_x":322,"top_left_y":1402,"width":1425,"height":49},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7688d0d7d314b68950239a3edf99535","type":"text","conversion_output":true,"text":"commence at the 30 day assessment will be assumed to be related to surgery and will be","text_display":" commence at the 30 day assessment will be assumed to be related to surgery and will be","confidence":0.98779296875,"confidence_rate":0.9998693473763118},{"cnt":[[320,1452],[1682,1452],[1682,1497],[320,1497]],"region":{"top_left_x":320,"top_left_y":1452,"width":1363,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d8e66cec478a4c5989be917ae381626c","type":"text","conversion_output":true,"text":"assigned an onset date of 0.10 days post-surgery. Onset of disability at 3 or 6 months","text_display":" assigned an onset date of 0.10 days post-surgery. Onset of disability at 3 or 6 months","confidence":0.9990236759185791,"confidence_rate":0.9999902320377446},{"cnt":[[322,1500],[1708,1500],[1708,1545],[322,1545]],"region":{"top_left_x":322,"top_left_y":1499,"width":1387,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10c1e620a17c4f2c8c959f72bb08b1c2","type":"text","conversion_output":true,"text":"postoperatively will typically be after an incident/illness in the postoperative follow-up","text_display":" postoperatively will typically be after an incident/illness in the postoperative follow-up","confidence":1,"confidence_rate":1},{"cnt":[[322,1547],[1772,1547],[1772,1592],[322,1592]],"region":{"top_left_x":322,"top_left_y":1546,"width":1451,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b482b7b92614e1db27558f5f8af0140","type":"text","conversion_output":true,"text":"period, and for these events the self-reported date of such onset will be utilised. If no such","text_display":" period, and for these events the self-reported date of such onset will be utilised. If no such","confidence":1,"confidence_rate":1},{"cnt":[[320,1594],[1592,1594],[1592,1639],[320,1639]],"region":{"top_left_x":320,"top_left_y":1594,"width":1272,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4445c19dc5734eb393a057613a7e7d55","type":"text","conversion_output":true,"text":"event is documented, then the current time point (interview date) will be used.","text_display":" event is documented, then the current time point (interview date) will be used.","confidence":1,"confidence_rate":1},{"cnt":[[318,1641],[1725,1641],[1725,1689],[318,1689]],"region":{"top_left_x":317,"top_left_y":1641,"width":1409,"height":48},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2aedbd7f10f4c23aa8710348166cdb2","type":"text","conversion_output":true,"text":"The time to the primary endpoint is defined as the time of the onset of persistent (>=6-","text_display":" The time to the primary endpoint is defined as the time of the onset of persistent (>=6","confidence":0.9702567919157445,"confidence_rate":0.9996753805649522},{"cnt":[[322,1691],[1729,1691],[1729,1738],[322,1738]],"region":{"top_left_x":322,"top_left_y":1690,"width":1408,"height":49},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15c6dedb50294837b9bc960025dd1cf5","type":"text","conversion_output":true,"text":"month) disability or death, whichever occurs first. Time at risk will commence at start of","text_display":"month) disability or death, whichever occurs first. Time at risk will commence at start of","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[320,1740],[1603,1740],[1603,1785],[320,1785]],"region":{"top_left_x":320,"top_left_y":1740,"width":1283,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d8f6f9b541134ceaa786430ec2374b68","type":"text","conversion_output":true,"text":"surgery to accommodate the potential for intraoperative mortality. Patients not","text_display":" surgery to accommodate the potential for intraoperative mortality. Patients not","confidence":1,"confidence_rate":1},{"cnt":[[320,1788],[1699,1788],[1699,1833],[320,1833]],"region":{"top_left_x":320,"top_left_y":1787,"width":1380,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"afdab499722b40f8a93cd06b15f02686","type":"text","conversion_output":true,"text":"experiencing the primary endpoint event will be censored at their date of last contact.","text_display":" experiencing the primary endpoint event will be censored at their date of last contact.","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[320,1835],[1755,1835],[1755,1880],[320,1880]],"region":{"top_left_x":320,"top_left_y":1834,"width":1436,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed267ea2f9ec4bef9e470c2d505208bf","type":"text","conversion_output":true,"text":"Two supplementary approaches will be utilised to assess sensitivity to handling of missing","text_display":" Two supplementary approaches will be utilised to assess sensitivity to handling of missing","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[320,1882],[1747,1882],[1747,1927],[320,1927]],"region":{"top_left_x":320,"top_left_y":1882,"width":1427,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3860178e62cc409eaa8614a9ff0189a0","type":"text","conversion_output":true,"text":"WHODAS assessments for subjects known to be alive at those assessment times: (a) they","text_display":" WHODAS assessments for subjects known to be alive at those assessment times: (a) they","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[320,1929],[1626,1929],[1626,1979],[320,1979]],"region":{"top_left_x":320,"top_left_y":1929,"width":1307,"height":50},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a42567f36df349cb9c2bed5337220ef9","type":"text","conversion_output":true,"text":"will be given a disabled score (WHODAS of 24), and (b) they will be imputed using","text_display":" will be given a disabled score (WHODAS of 24), and (b) they will be imputed using","confidence":0.73095703125,"confidence_rate":0.9963624389694257},{"cnt":[[320,1977],[1727,1977],[1727,2024],[320,2024]],"region":{"top_left_x":320,"top_left_y":1976,"width":1408,"height":48},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54ff81890dac4785a786e74ae75f9633","type":"text","conversion_output":true,"text":"information from baseline and post-baseline variables (see statistical analysis methods).","text_display":" information from baseline and post-baseline variables (see statistical analysis methods).","confidence":0.99609375,"confidence_rate":0.9999583636399967},{"cnt":[[316,2108],[1439,2108],[1439,2159],[316,2159]],"region":{"top_left_x":315,"top_left_y":2107,"width":1125,"height":53},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c123bac2dbd047b9bc0a97fdff13088f","type":"section_header","conversion_output":false,"children_ids":["baba7909d6c6449cb4909336bc2b180a"],"text":"","text_display":""},{"cnt":[[320,2110],[1435,2110],[1435,2155],[320,2155]],"region":{"top_left_x":320,"top_left_y":2109,"width":1116,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"baba7909d6c6449cb4909336bc2b180a","type":"text","conversion_output":true,"parent_id":"c123bac2dbd047b9bc0a97fdff13088f","text":"Alternative 'new onset disability' definition of the primary endpoint","text_display":"\n\n\\section*{Alternative 'new onset disability' definition of the primary endpoint}","confidence":0.9980475902557373,"confidence_rate":0.9999735906435898},{"cnt":[[318,2159],[1656,2159],[1656,2206],[318,2206]],"region":{"top_left_x":317,"top_left_y":2159,"width":1340,"height":48},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6178450b23b5486b9a258ec414cf788a","type":"text","conversion_output":true,"text":"An additional sensitivity analysis will done for an alternative definition of persistent","text_display":"\n\nAn additional sensitivity analysis will done for an alternative definition of persistent","confidence":1,"confidence_rate":1},{"cnt":[[320,2209],[1682,2209],[1682,2254],[320,2254]],"region":{"top_left_x":320,"top_left_y":2208,"width":1363,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9aea7c6a502c472fb08df27e111a9baf","type":"text","conversion_output":true,"text":"disability, considered as 'new onset' persistent disability, defined as an increase from","text_display":" disability, considered as 'new onset' persistent disability, defined as an increase from","confidence":0.99853515625,"confidence_rate":0.9999842375685026},{"cnt":[[322,2254],[1772,2254],[1772,2301],[322,2301]],"region":{"top_left_x":322,"top_left_y":2253,"width":1451,"height":48},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70d755624dd14e41915332d5aa777540","type":"text","conversion_output":true,"text":"baseline of >=4 points in WHODAS scores that persists for at least 6 months. The definition","text_display":" baseline of >=4 points in WHODAS scores that persists for at least 6 months. The definition","confidence":0.77099609375,"confidence_rate":0.9973764579025045},{"cnt":[[322,2303],[1794,2303],[1794,2348],[322,2348]],"region":{"top_left_x":322,"top_left_y":2303,"width":1472,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91a8d112566c4815a3f5ca89c7777349","type":"text","conversion_output":true,"text":"of time to the first of new-onset persistent disability or death will use the same principles as","text_display":" of time to the first of new-onset persistent disability or death will use the same principles as","confidence":1,"confidence_rate":1},{"cnt":[[320,2350],[733,2350],[733,2396],[320,2396]],"region":{"top_left_x":320,"top_left_y":2350,"width":413,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df4f954776bf489cae9ecfaf119ba603","type":"text","conversion_output":true,"text":"for the primary endpoint.","text_display":" for the primary endpoint.","confidence":1,"confidence_rate":1},{"cnt":[[318,2398],[672,2398],[672,2447],[318,2447]],"region":{"top_left_x":317,"top_left_y":2397,"width":356,"height":51},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae6a00d7385146c3bce0ccf25e38f6de","type":"section_header","conversion_output":false,"children_ids":["22621cec98704763be2f40346808f787"],"text":"","text_display":""},{"cnt":[[322,2400],[672,2400],[672,2443],[322,2443]],"region":{"top_left_x":322,"top_left_y":2399,"width":351,"height":44},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22621cec98704763be2f40346808f787","type":"text","conversion_output":true,"parent_id":"ae6a00d7385146c3bce0ccf25e38f6de","text":"Secondary endpoints","text_display":"\n\n\\section*{Secondary endpoints}","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"8501b684-3e70-49a9-81f9-ab3940fd1a00-3","page":3,"lines":[{"cnt":[[380,249],[1742,249],[1742,301],[380,301]],"region":{"top_left_x":380,"top_left_y":249,"width":1363,"height":52},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2e664afed8c4b3fab2315a7084ef073","type":"text","conversion_output":true,"text":"1. Death/survival: all-cause mortality at 90 days, and survival up to 12","text_display":"\n1. Death/survival: all-cause mortality at 90 days, and survival up to 12","confidence":0.7059337422251701,"confidence_rate":0.9956016770855148},{"cnt":[[440,314],[855,314],[855,363],[440,363]],"region":{"top_left_x":440,"top_left_y":313,"width":416,"height":51},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a15ad20c1064e42afba75ebdb30102b","type":"text","conversion_output":true,"text":"months after surgery.","text_display":" months after surgery.","confidence":0.9921875,"confidence_rate":0.9996983848234277},{"cnt":[[378,490],[1772,490],[1772,544],[378,544]],"region":{"top_left_x":378,"top_left_y":489,"width":1395,"height":55},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff633ff4f5fa4120954ed8569f58dc8a","type":"text","conversion_output":true,"text":"2. A composite (pooled) and individual incidence of 30 -day mortality and","text_display":"\n2. A composite (pooled) and individual incidence of 30 -day mortality and","confidence":0.99365234375,"confidence_rate":0.9999213871854246},{"cnt":[[443,559],[1803,559],[1803,606],[443,606]],"region":{"top_left_x":442,"top_left_y":558,"width":1361,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41b29258554848c9854f78d1944e5119","type":"text","conversion_output":true,"text":"major septic complications, where the latter is defined as the composite","text_display":" major septic complications, where the latter is defined as the composite","confidence":1,"confidence_rate":1},{"cnt":[[440,619],[1785,619],[1785,668],[440,668]],"region":{"top_left_x":440,"top_left_y":618,"width":1346,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa57be450a9e4da69cce24dbcc606080","type":"text","conversion_output":true,"text":"of sepsis, surgical site infection, anastomotic leak and pneumonia at 30","text_display":" of sepsis, surgical site infection, anastomotic leak and pneumonia at 30","confidence":0.9897651672363281,"confidence_rate":0.9998646464137181},{"cnt":[[438,683],[1687,683],[1687,733],[438,733]],"region":{"top_left_x":438,"top_left_y":683,"width":1249,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23f56d4f0b3043399ed871315b918ee4","type":"text","conversion_output":true,"text":"days post-surgery. [Detailed clinical definitions are provided in the","text_display":" days post-surgery. [Detailed clinical definitions are provided in the","confidence":1,"confidence_rate":1},{"cnt":[[440,746],[617,746],[617,797],[440,797]],"region":{"top_left_x":440,"top_left_y":745,"width":177,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"330e2d97d0ba4553bee0291945b590e6","type":"text","conversion_output":true,"text":"Protocol]","text_display":" Protocol]","confidence":1,"confidence_rate":1},{"cnt":[[378,810],[1768,810],[1768,862],[378,862]],"region":{"top_left_x":378,"top_left_y":809,"width":1391,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71081527ae404fb7b41c7d7b07b81d11","type":"text","conversion_output":true,"text":"3. Acute Kidney Injury (AKI): according to the Kidney Disease: Improving","text_display":"\n3. Acute Kidney Injury (AKI): according to the Kidney Disease: Improving","confidence":1,"confidence_rate":1},{"cnt":[[443,872],[1768,872],[1768,922],[443,922]],"region":{"top_left_x":442,"top_left_y":872,"width":1327,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4e6ffa9495b4abcb1387762bf4e93c9","type":"text","conversion_output":true,"text":"Global Outcomes group criteria, but not urine output-for Stage 2 or","text_display":" Global Outcomes group criteria, but not urine output-for Stage 2 or","confidence":1,"confidence_rate":1},{"cnt":[[443,937],[1635,937],[1635,982],[443,982]],"region":{"top_left_x":442,"top_left_y":936,"width":1193,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"778786dd5fd74de9b90a29b61ec2fa6b","type":"text","conversion_output":true,"text":"worse AKI defined as at least twofold increase in creatinine, or","text_display":" worse AKI defined as at least twofold increase in creatinine, or","confidence":1,"confidence_rate":1},{"cnt":[[440,999],[1412,999],[1412,1046],[440,1046]],"region":{"top_left_x":440,"top_left_y":999,"width":972,"height":48},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09ec41a985e9411a865ed650dac3272e","type":"text","conversion_output":true,"text":"estimated glomerular filtration rate decrease \\(> 5 0 \\%\\).","text_display":" estimated glomerular filtration rate decrease \\(> 5 0 \\%\\).","confidence":0.7364092407135672,"confidence_rate":0.9951551192236868},{"cnt":[[440,1169],[1699,1169],[1699,1218],[440,1218]],"region":{"top_left_x":440,"top_left_y":1168,"width":1260,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1aa7de8d8bd46479dc2ff49115b1ffd","type":"text","conversion_output":true,"text":"Since a restrictive intravenous fluid regimen may artificially elevate","text_display":"\n\nSince a restrictive intravenous fluid regimen may artificially elevate","confidence":1,"confidence_rate":1},{"cnt":[[438,1233],[1798,1233],[1798,1276],[438,1276]],"region":{"top_left_x":438,"top_left_y":1233,"width":1361,"height":44},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5c8989656124d1cb1d69291c1abecd0","type":"text","conversion_output":true,"text":"serum creatinine due to a smaller dilutional effect from less intravenous","text_display":" serum creatinine due to a smaller dilutional effect from less intravenous","confidence":1,"confidence_rate":1},{"cnt":[[440,1293],[1798,1293],[1798,1343],[440,1343]],"region":{"top_left_x":440,"top_left_y":1293,"width":1359,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddfb806580364338b08f058b593ffa64","type":"text","conversion_output":true,"text":"fluids, we will calculate adjusted creatinine following the approach of Liu","text_display":" fluids, we will calculate adjusted creatinine following the approach of Liu","confidence":1,"confidence_rate":1},{"cnt":[[440,1358],[1076,1358],[1076,1407],[440,1407]],"region":{"top_left_x":440,"top_left_y":1357,"width":637,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e934503204d4342aa07668d3a944c7b","type":"text","conversion_output":true,"text":"(2011, Reference 1 below), where","text_display":" (2011, Reference 1 below), where","confidence":1,"confidence_rate":1},{"cnt":[[438,1429],[1732,1429],[1732,1472],[438,1472]],"region":{"top_left_x":438,"top_left_y":1428,"width":1294,"height":44},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd2b9106cb254b7c8617e21db56cb82c","type":"text","conversion_output":true,"text":"adjusted creatinine \\(=\\) serum creatinine × \\((1+\\) cumulative fluid balance/total body water \\()\\),","text_display":"\nadjusted creatinine \\(=\\) serum creatinine × \\((1+\\) cumulative fluid balance/total body water \\()\\),","confidence":0.5172401808094946,"confidence_rate":0.9939144448116034},{"cnt":[[438,1491],[1656,1491],[1656,1532],[438,1532]],"region":{"top_left_x":438,"top_left_y":1491,"width":1219,"height":41},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fdd9abcaf544ccea2d03f9c5e1c699f","type":"text","conversion_output":true,"text":"and assuming that total body water is \\(60 \\%\\) of body weight, expressed in mL . Serum","text_display":" and assuming that total body water is \\(60 \\%\\) of body weight, expressed in mL . Serum","confidence":0.99267578125,"confidence_rate":0.9999226222303292},{"cnt":[[438,1536],[1729,1536],[1729,1577],[438,1577]],"region":{"top_left_x":438,"top_left_y":1536,"width":1292,"height":41},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4639bc8afde942eca89cb6fd54e19a88","type":"text","conversion_output":true,"text":"creatinine is measured on days 1 and 3 and the maximum value in the patient's hospital","text_display":" creatinine is measured on days 1 and 3 and the maximum value in the patient's hospital","confidence":1,"confidence_rate":1},{"cnt":[[438,1581],[1781,1581],[1781,1622],[438,1622]],"region":{"top_left_x":438,"top_left_y":1581,"width":1344,"height":42},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a678f06964b44f09da8e272b447870c","type":"text","conversion_output":true,"text":"stay. We will apply adjustments to creatinine levels at days 1 and 3 only. Fluid intake will be","text_display":" stay. We will apply adjustments to creatinine levels at days 1 and 3 only. Fluid intake will be","confidence":1,"confidence_rate":1},{"cnt":[[438,1624],[1751,1624],[1751,1665],[438,1665]],"region":{"top_left_x":438,"top_left_y":1624,"width":1313,"height":42},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad649b8296a744979a95bfeb3946e83b","type":"text","conversion_output":true,"text":"accumulated using IV fluids administered intraoperatively, in recovery, and on days 1 to 3","text_display":" accumulated using IV fluids administered intraoperatively, in recovery, and on days 1 to 3","confidence":1,"confidence_rate":1},{"cnt":[[438,1667],[1794,1667],[1794,1710],[438,1710]],"region":{"top_left_x":438,"top_left_y":1667,"width":1356,"height":44},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbb05b6f657c429e9a43d9c1fe8206f0","type":"text","conversion_output":true,"text":"postoperatively, plus the volume of any blood transfusions administered. Fluid outputs from","text_display":" postoperatively, plus the volume of any blood transfusions administered. Fluid outputs from","confidence":1,"confidence_rate":1},{"cnt":[[438,1712],[1712,1712],[1712,1755],[438,1755]],"region":{"top_left_x":438,"top_left_y":1712,"width":1275,"height":44},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5be19a1996b140f786ae0d96b908ba7a","type":"text","conversion_output":true,"text":"the time of surgery to Day 1 post-surgery will be accumulated using the recorded urine","text_display":" the time of surgery to Day 1 post-surgery will be accumulated using the recorded urine","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[438,1757],[1762,1757],[1762,1798],[438,1798]],"region":{"top_left_x":438,"top_left_y":1757,"width":1324,"height":42},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11f71ea617a741508b7ae9bf79eb04e4","type":"text","conversion_output":true,"text":"outputs, blood losses and volumes in surgical drains. Missing fluid output components will","text_display":" outputs, blood losses and volumes in surgical drains. Missing fluid output components will","confidence":1,"confidence_rate":1},{"cnt":[[438,1800],[1785,1800],[1785,1841],[438,1841]],"region":{"top_left_x":438,"top_left_y":1800,"width":1348,"height":42},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d341f7a27f36497c86e7d7cc1613f614","type":"text","conversion_output":true,"text":"be imputed to prevent adjustment factors being missing when creatinine levels are present.","text_display":" be imputed to prevent adjustment factors being missing when creatinine levels are present.","confidence":1,"confidence_rate":1},{"cnt":[[438,1843],[1678,1843],[1678,1884],[438,1884]],"region":{"top_left_x":438,"top_left_y":1843,"width":1240,"height":42},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30a48896b6cf4b6c8cc4d52648ecdb2f","type":"text","conversion_output":true,"text":"Fluid outputs on days 2 and 3 are not recorded, so these will be estimated under the","text_display":" Fluid outputs on days 2 and 3 are not recorded, so these will be estimated under the","confidence":0.99853515625,"confidence_rate":0.9999845694066055},{"cnt":[[438,1886],[1794,1886],[1794,1929],[438,1929]],"region":{"top_left_x":438,"top_left_y":1886,"width":1356,"height":44},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35b930a218184cc9bcff82c66adb4ede","type":"text","conversion_output":true,"text":"assumption of a net fluid balance of zero on each of days 2 and 3; this will form the principal","text_display":" assumption of a net fluid balance of zero on each of days 2 and 3; this will form the principal","confidence":0.986328125,"confidence_rate":0.9998663565450225},{"cnt":[[438,1929],[1803,1929],[1803,1972],[438,1972]],"region":{"top_left_x":438,"top_left_y":1929,"width":1365,"height":44},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"003bee9fa13d4ad880507b24ddfbbb7a","type":"text","conversion_output":true,"text":"analysis. Sensitivity to this assumption will be assessed using two alternatives: (a) assuming a","text_display":" analysis. Sensitivity to this assumption will be assessed using two alternatives: (a) assuming a","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[438,1977],[1781,1977],[1781,2017],[438,2017]],"region":{"top_left_x":438,"top_left_y":1976,"width":1344,"height":42},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c37cfc3773794e1490a7554ed65ea7e1","type":"text","conversion_output":true,"text":"zero cumulative fluid balance at day 3, and (b) assuming the ratio of intake to outputs up to","text_display":" zero cumulative fluid balance at day 3, and (b) assuming the ratio of intake to outputs up to","confidence":0.9985356330871582,"confidence_rate":0.9999850466409257},{"cnt":[[438,2020],[1790,2020],[1790,2060],[438,2060]],"region":{"top_left_x":438,"top_left_y":2019,"width":1352,"height":42},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a71450adda84dd6ab5585de52e18986","type":"text","conversion_output":true,"text":"day 1 persists on days 2 and 3 . These two assumptions enclose that of the principal analysis.","text_display":" day 1 persists on days 2 and 3 . These two assumptions enclose that of the principal analysis.","confidence":0.990234375,"confidence_rate":0.9999091372630062},{"cnt":[[443,2093],[1712,2093],[1712,2144],[443,2144]],"region":{"top_left_x":442,"top_left_y":2092,"width":1271,"height":53},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e577cfa6853546cd833f1c4c7aa4eed2","type":"text","conversion_output":true,"text":"We will also report the use of renal replacement therapy up to 90","text_display":"\n\nWe will also report the use of renal replacement therapy up to 90","confidence":0.9990234375,"confidence_rate":0.9999858401053562},{"cnt":[[440,2157],[1674,2157],[1674,2206],[440,2206]],"region":{"top_left_x":440,"top_left_y":2157,"width":1234,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ce2a20e41994e1193c042f07a68ccdc","type":"text","conversion_output":true,"text":"days after surgery; and delta-creatinine, defined as the difference","text_display":" days after surgery; and delta-creatinine, defined as the difference","confidence":1,"confidence_rate":1},{"cnt":[[440,2221],[1764,2221],[1764,2271],[440,2271]],"region":{"top_left_x":440,"top_left_y":2221,"width":1324,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b11d167bb7e4b4eb9faffc28236387d","type":"text","conversion_output":true,"text":"between the maximum (fluid-adjusted) postoperative serum creatinine","text_display":" between the maximum (fluid-adjusted) postoperative serum creatinine","confidence":1,"confidence_rate":1},{"cnt":[[438,2282],[1360,2282],[1360,2333],[438,2333]],"region":{"top_left_x":438,"top_left_y":2281,"width":922,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"035c67d7f35a48f29d968b062b13f26f","type":"text","conversion_output":true,"text":"level and the preoperative serum creatinine level-","text_display":" level and the preoperative serum creatinine level-","confidence":0.99951171875,"confidence_rate":0.9999911200303706}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"8501b684-3e70-49a9-81f9-ab3940fd1a00-4","page":4,"lines":[{"cnt":[[378,249],[1697,249],[1697,301],[378,301]],"region":{"top_left_x":378,"top_left_y":249,"width":1320,"height":52},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f3ad68ee99f64d52aab60e5d510657fc","type":"text","conversion_output":true,"text":"4. Pulmonary oedema: documented evidence of respiratory distress or","text_display":"\n4. Pulmonary oedema: documented evidence of respiratory distress or","confidence":1,"confidence_rate":1},{"cnt":[[438,314],[1717,314],[1717,363],[438,363]],"region":{"top_left_x":438,"top_left_y":313,"width":1279,"height":51},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3965ba2200664673be802f2f2c8a6a54","type":"text","conversion_output":true,"text":"impaired oxygenation and radiological evidence of pulmonary oedema.","text_display":" impaired oxygenation and radiological evidence of pulmonary oedema.","confidence":0.52490234375,"confidence_rate":0.9910879629902155},{"cnt":[[380,378],[1779,378],[1779,428],[380,428]],"region":{"top_left_x":380,"top_left_y":378,"width":1399,"height":50},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a04827adaf6457c8d9ffa9a12834b80","type":"text","conversion_output":true,"text":"5. Duration of mechanical ventilation: Defined as additive over all episodes","text_display":"\n5. Duration of mechanical ventilation: Defined as additive over all episodes","confidence":0.99951171875,"confidence_rate":0.9999939703823991},{"cnt":[[440,440],[1618,440],[1618,492],[440,492]],"region":{"top_left_x":440,"top_left_y":440,"width":1178,"height":52},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4f09efae2ac439497f32d3164dbfb3a","type":"text","conversion_output":true,"text":"up to 90 days after surgery. This will be reported as (a) the","text_display":" up to 90 days after surgery. This will be reported as (a) the","confidence":1,"confidence_rate":1},{"cnt":[[438,503],[1742,503],[1742,554],[438,554]],"region":{"top_left_x":438,"top_left_y":502,"width":1305,"height":53},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"026c0a05bd584b7fb267b9cca5f8a911","type":"text","conversion_output":true,"text":"proportion of patients requiring ventilation; and (b) the duration of","text_display":" proportion of patients requiring ventilation; and (b) the duration of","confidence":1,"confidence_rate":1},{"cnt":[[443,567],[1257,567],[1257,617],[443,617]],"region":{"top_left_x":442,"top_left_y":567,"width":815,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd5684dd353a4ce58235479014e76813","type":"text","conversion_output":true,"text":"ventilation in patients receiving ventilation.","text_display":" ventilation in patients receiving ventilation.","confidence":0.9404296875,"confidence_rate":0.9987964426254412},{"cnt":[[380,632],[1755,632],[1755,681],[380,681]],"region":{"top_left_x":380,"top_left_y":631,"width":1376,"height":51},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ceeff7d4458e423c9aa30238a11bbaa0","type":"text","conversion_output":true,"text":"6. Inflammation: plasma \\(C\\) reactive protein concentration on day 3 after","text_display":"\n6. Inflammation: plasma \\(C\\) reactive protein concentration on day 3 after","confidence":0.9985356330871582,"confidence_rate":0.9999821289383974},{"cnt":[[443,700],[591,700],[591,741],[443,741]],"region":{"top_left_x":442,"top_left_y":700,"width":149,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77d279fe0dbe449eac5872877025a23b","type":"text","conversion_output":true,"text":"surgery.","text_display":" surgery.","confidence":0.68505859375,"confidence_rate":0.9713229958298333},{"cnt":[[378,756],[1738,756],[1738,806],[378,806]],"region":{"top_left_x":378,"top_left_y":756,"width":1361,"height":50},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9097503f95fd46ab8f164c7a99457034","type":"text","conversion_output":true,"text":"7. Tissue perfusion marker: peak serum lactate concentration within 24","text_display":"\n7. Tissue perfusion marker: peak serum lactate concentration within 24","confidence":0.9941432476043701,"confidence_rate":0.9999206251715551},{"cnt":[[443,821],[763,821],[763,870],[443,870]],"region":{"top_left_x":442,"top_left_y":820,"width":321,"height":51},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2197f39a27c141d985f32e6cd9f29836","type":"text","conversion_output":true,"text":"hours of surgery.","text_display":" hours of surgery.","confidence":1,"confidence_rate":1},{"cnt":[[378,881],[1798,881],[1798,932],[378,932]],"region":{"top_left_x":378,"top_left_y":880,"width":1421,"height":53},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0ffd2de7ed045b1b67116723fa1ecd8","type":"text","conversion_output":true,"text":"8. Any blood transfusion: including red cell, fresh frozen plasma or platelet","text_display":"\n8. Any blood transfusion: including red cell, fresh frozen plasma or platelet","confidence":1,"confidence_rate":1},{"cnt":[[443,945],[1781,945],[1781,995],[443,995]],"region":{"top_left_x":442,"top_left_y":945,"width":1340,"height":50},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02f1e316899c432bb6b2ae43afc2a55e","type":"text","conversion_output":true,"text":"transfusion, from the initiation of surgery; and quantity of transfusion","text_display":" transfusion, from the initiation of surgery; and quantity of transfusion","confidence":1,"confidence_rate":1},{"cnt":[[440,1010],[1085,1010],[1085,1059],[440,1059]],"region":{"top_left_x":440,"top_left_y":1009,"width":645,"height":51},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e928033a92c74d95aacad06c818f17e3","type":"text","conversion_output":true,"text":"in patients receiving each product.","text_display":" in patients receiving each product.","confidence":0.95068359375,"confidence_rate":0.9987364494334199},{"cnt":[[378,1072],[1583,1072],[1583,1121],[378,1121]],"region":{"top_left_x":378,"top_left_y":1072,"width":1206,"height":50},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d95dfe8b45c84bc6a06b27d7c24e5fb8","type":"text","conversion_output":true,"text":"9. Unplanned admission to HDUIICU within 30 days of surgery.","text_display":"\n9. Unplanned admission to HDUIICU within 30 days of surgery.","confidence":0.6836912909056991,"confidence_rate":0.9944237115327885},{"cnt":[[380,1134],[1783,1134],[1783,1184],[380,1184]],"region":{"top_left_x":380,"top_left_y":1134,"width":1404,"height":50},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"badddf909b16442f9c950bfcfe6540fb","type":"text","conversion_output":true,"text":"10. Total HDU/ICU stay in patients admitted to HDU/ICU, including initial","text_display":"\n10. Total HDU/ICU stay in patients admitted to HDU/ICU, including initial","confidence":1,"confidence_rate":1},{"cnt":[[440,1199],[1371,1199],[1371,1248],[440,1248]],"region":{"top_left_x":440,"top_left_y":1198,"width":931,"height":51},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6dd5550f4524cb7a606951a328bf060","type":"text","conversion_output":true,"text":"admission and readmission duration up to day 30","text_display":" admission and readmission duration up to day 30","confidence":1,"confidence_rate":1},{"cnt":[[380,1263],[1577,1263],[1577,1311],[380,1311]],"region":{"top_left_x":380,"top_left_y":1263,"width":1197,"height":48},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0eb7aae2906c429fab67216192e5d875","type":"text","conversion_output":true,"text":"11. Total hospital stay, including any readmission up to day 30 .","text_display":"\n11. Total hospital stay, including any readmission up to day 30 .","confidence":0.7097208686172962,"confidence_rate":0.9953139791719989},{"cnt":[[380,1326],[1497,1326],[1497,1373],[380,1373]],"region":{"top_left_x":380,"top_left_y":1325,"width":1118,"height":48},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e9ca8fb70b243a8b125a809da0b4b42","type":"text","conversion_output":true,"text":"12. Quality of recovery: QoR-15 score on days 1, 3 and \\(30 \\cdot\\)","text_display":"\n12. Quality of recovery: QoR-15 score on days 1, 3 and \\(30 \\cdot\\)","confidence":0.9590874862237797,"confidence_rate":0.9993575452048403},{"cnt":[[380,1388],[1706,1388],[1706,1437],[380,1437]],"region":{"top_left_x":380,"top_left_y":1387,"width":1326,"height":51},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf619fbc2b02471cbbea74efc2b6d14b","type":"text","conversion_output":true,"text":"13. The rates of serious adverse events, and severity of adverse events","text_display":"\n13. The rates of serious adverse events, and severity of adverse events","confidence":0.99951171875,"confidence_rate":0.9999935736983052},{"cnt":[[443,1452],[1435,1452],[1435,1502],[443,1502]],"region":{"top_left_x":442,"top_left_y":1452,"width":994,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c445905f608b460b939abf6342852131","type":"text","conversion_output":true,"text":"(mild, moderate, severe), classified by organ system.","text_display":" (mild, moderate, severe), classified by organ system.","confidence":0.9990234375,"confidence_rate":0.9999831546307154},{"cnt":[[318,1504],[771,1504],[771,1551],[318,1551]],"region":{"top_left_x":317,"top_left_y":1503,"width":455,"height":49},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"200b4a597d014a17bd961014eabf7788","type":"section_header","conversion_output":false,"children_ids":["d82095f150a4453f993f80831706d6f1"],"text":"","text_display":""},{"cnt":[[322,1508],[767,1508],[767,1549],[322,1549]],"region":{"top_left_x":322,"top_left_y":1508,"width":445,"height":42},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d82095f150a4453f993f80831706d6f1","type":"text","conversion_output":true,"parent_id":"200b4a597d014a17bd961014eabf7788","text":"STATISTICAL ANALYSES","text_display":"\n\n\\section*{STATISTICAL ANALYSES}","confidence":1,"confidence_rate":1},{"cnt":[[322,1560],[995,1560],[995,1605],[322,1605]],"region":{"top_left_x":322,"top_left_y":1559,"width":673,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b690fe02a8da48f1aba0c8b06d836b79","type":"text","conversion_output":true,"text":"Primary endpoint: disability-free survival","text_display":"\n\nPrimary endpoint: disability-free survival","confidence":1,"confidence_rate":1},{"cnt":[[322,1607],[1777,1607],[1777,1652],[322,1652]],"region":{"top_left_x":322,"top_left_y":1607,"width":1455,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c57e0dd52a8e4e9698c99a27fbf22ef3","type":"text","conversion_output":true,"text":"Disability free survival will be displayed with Kaplan-Meier plots, and described with event-","text_display":"\nDisability free survival will be displayed with Kaplan-Meier plots, and described with event","confidence":1,"confidence_rate":1},{"cnt":[[322,1654],[1794,1654],[1794,1699],[322,1699]],"region":{"top_left_x":322,"top_left_y":1654,"width":1472,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53e64338d1d34619ab07af4ab541d22d","type":"text","conversion_output":true,"text":"free proportions in each treatment arm obtained from these plots at days \\(1,30,90,180\\) and","text_display":"free proportions in each treatment arm obtained from these plots at days \\(1,30,90,180\\) and","confidence":0.9699983755599533,"confidence_rate":0.999682749478691},{"cnt":[[322,1702],[1760,1702],[1760,1747],[322,1747]],"region":{"top_left_x":322,"top_left_y":1701,"width":1438,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef6af3e727aa4b0da1bc44dcf0eaa8a4","type":"text","conversion_output":true,"text":"365 days post-surgery. Comparison of overall time to events between treatment arms will","text_display":" 365 days post-surgery. Comparison of overall time to events between treatment arms will","confidence":0.9790139198303223,"confidence_rate":0.9997669566298628},{"cnt":[[322,1749],[1796,1749],[1796,1794],[322,1794]],"region":{"top_left_x":322,"top_left_y":1748,"width":1475,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"37e5455257f440b9b9591d9f60ea71fe","type":"text","conversion_output":true,"text":"be made using the log rank test and the Cox proportional hazards model to provide a hazard","text_display":" be made using the log rank test and the Cox proportional hazards model to provide a hazard","confidence":1,"confidence_rate":1},{"cnt":[[322,1796],[1704,1796],[1704,1841],[322,1841]],"region":{"top_left_x":322,"top_left_y":1796,"width":1382,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70d0bc269ec94312afd7cf4ff91c1e1a","type":"text","conversion_output":true,"text":"ratio and \\(95 \\% Cl\\). Assessment of proportionality of hazards will be based on tests using","text_display":" ratio and \\(95 \\% Cl\\). Assessment of proportionality of hazards will be based on tests using","confidence":0.9921910762786865,"confidence_rate":0.9999200075564114},{"cnt":[[322,1846],[1798,1846],[1798,1893],[322,1893]],"region":{"top_left_x":322,"top_left_y":1845,"width":1477,"height":48},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c91210aea064b5fa407e070117f7a5e","type":"text","conversion_output":true,"text":"Schoenfeld residuals. The principal analysis will not impute missing WHODAS measurements","text_display":" Schoenfeld residuals. The principal analysis will not impute missing WHODAS measurements","confidence":1,"confidence_rate":1},{"cnt":[[322,1893],[1747,1893],[1747,1938],[322,1938]],"region":{"top_left_x":322,"top_left_y":1892,"width":1425,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc35a2528aaa4dae90dab92190c9baa1","type":"text","conversion_output":true,"text":"for patients known to be alive at those assessment times. The first sensitivity analysis will","text_display":" for patients known to be alive at those assessment times. The first sensitivity analysis will","confidence":1,"confidence_rate":1},{"cnt":[[322,1942],[1803,1942],[1803,1987],[322,1987]],"region":{"top_left_x":322,"top_left_y":1942,"width":1481,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb5bda932eab4f588d80127828b58fe7","type":"text","conversion_output":true,"text":"impute all missing WHODAS assessments for subjects known to be alive at those assessment","text_display":" impute all missing WHODAS assessments for subjects known to be alive at those assessment","confidence":1,"confidence_rate":1},{"cnt":[[322,1989],[1725,1989],[1725,2035],[322,2035]],"region":{"top_left_x":322,"top_left_y":1989,"width":1404,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4bc7d1a6b0041e397b8e0b1321dfb69","type":"text","conversion_output":true,"text":"times by giving them a disabled score (WHODAS of 24). A second sensitivity analysis will","text_display":" times by giving them a disabled score (WHODAS of 24). A second sensitivity analysis will","confidence":0.98046875,"confidence_rate":0.9997879310344503},{"cnt":[[322,2037],[1755,2037],[1755,2082],[322,2082]],"region":{"top_left_x":322,"top_left_y":2036,"width":1434,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2407cc9ca3241f1a6b7a6ebdaa69758","type":"text","conversion_output":true,"text":"impute the missing WHODAS assessments using multiple imputation, with the imputation","text_display":" impute the missing WHODAS assessments using multiple imputation, with the imputation","confidence":1,"confidence_rate":1},{"cnt":[[322,2084],[1691,2084],[1691,2129],[322,2129]],"region":{"top_left_x":322,"top_left_y":2083,"width":1369,"height":47},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1af4b45a40144e66bcf9505dd13d8d1c","type":"text","conversion_output":true,"text":"model employing baseline and post-baseline information predictive of missingness or","text_display":" model employing baseline and post-baseline information predictive of missingness or","confidence":1,"confidence_rate":1},{"cnt":[[322,2133],[1622,2133],[1622,2176],[322,2176]],"region":{"top_left_x":322,"top_left_y":2133,"width":1301,"height":44},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb1386f4e4364e13925f13e3f081a902","type":"text","conversion_output":true,"text":"WHODAS scores, separately in each treatment arm, with results combined across","text_display":" WHODAS scores, separately in each treatment arm, with results combined across","confidence":1,"confidence_rate":1},{"cnt":[[322,2179],[836,2179],[836,2224],[322,2224]],"region":{"top_left_x":322,"top_left_y":2178,"width":514,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd52177af5744658b3e491f4f3113f86","type":"text","conversion_output":true,"text":"imputations using Rubin's rules.","text_display":" imputations using Rubin's rules.","confidence":1,"confidence_rate":1},{"cnt":[[322,2230],[1278,2230],[1278,2275],[322,2275]],"region":{"top_left_x":322,"top_left_y":2230,"width":957,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e93fe4f340174047826b09e3ea41c385","type":"text","conversion_output":true,"text":"Alternative 'new onset' definition of the primary endpoint","text_display":"\nAlternative 'new onset' definition of the primary endpoint","confidence":0.998535871389322,"confidence_rate":0.9999767431038692},{"cnt":[[322,2277],[1751,2277],[1751,2322],[322,2322]],"region":{"top_left_x":322,"top_left_y":2277,"width":1429,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"054ee0dddbe04a2d8d37d59769c5b585","type":"text","conversion_output":true,"text":"Analysis of disability-free survival based on the ˋnew onset' persistent disability definition","text_display":"\nAnalysis of disability-free survival based on the ˋnew onset' persistent disability definition","confidence":0.7499284744262695,"confidence_rate":0.9970973779039997},{"cnt":[[322,2325],[1263,2325],[1263,2370],[322,2370]],"region":{"top_left_x":322,"top_left_y":2324,"width":942,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a4c00fd11d1456c9bc51f3866e67555","type":"text","conversion_output":true,"text":"will follow the same approach as for the primary endpoint.","text_display":" will follow the same approach as for the primary endpoint.","confidence":1,"confidence_rate":1},{"cnt":[[322,2372],[556,2372],[556,2413],[322,2413]],"region":{"top_left_x":322,"top_left_y":2371,"width":235,"height":42},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0228afde2b749e99910b09de71b8806","type":"text","conversion_output":true,"text":"Time to death","text_display":"\nTime to death","confidence":0.99951171875,"confidence_rate":0.9999728670071003},{"cnt":[[322,2419],[1669,2419],[1669,2464],[322,2464]],"region":{"top_left_x":322,"top_left_y":2419,"width":1348,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"263e081c427947f6bd99affffea19300","type":"text","conversion_output":true,"text":"Analysis of time to death will follow the same approach as for the primary endpoint.","text_display":"\nAnalysis of time to death will follow the same approach as for the primary endpoint.","confidence":1,"confidence_rate":1},{"cnt":[[322,2466],[591,2466],[591,2507],[322,2507]],"region":{"top_left_x":322,"top_left_y":2466,"width":269,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78f9334536134def83fe9df9990ac4d1","type":"text","conversion_output":true,"text":"Other outcomes","text_display":"\nOther outcomes","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"8501b684-3e70-49a9-81f9-ab3940fd1a00-5","page":5,"lines":[{"cnt":[[322,241],[1762,241],[1762,286],[322,286]],"region":{"top_left_x":322,"top_left_y":240,"width":1440,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b1fa43f573d450fa68a372c9d3c4147","type":"text","conversion_output":true,"text":"Secondary outcomes measured on a binary scale ( \\(1,2,3,4,8,9\\) ) will be summarised using","text_display":"\n\nSecondary outcomes measured on a binary scale ( \\(1,2,3,4,8,9\\) ) will be summarised using","confidence":0.9660937814041972,"confidence_rate":0.9996331059680099},{"cnt":[[322,288],[1624,288],[1624,333],[322,333]],"region":{"top_left_x":322,"top_left_y":287,"width":1303,"height":47},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee89466cc7e74a0388ebb15271f4c0b2","type":"text","conversion_output":true,"text":"proportions in each treatment arm and analysed using binomial regression with a","text_display":" proportions in each treatment arm and analysed using binomial regression with a","confidence":0.99853515625,"confidence_rate":0.9999825487512927},{"cnt":[[322,335],[1635,335],[1635,380],[322,380]],"region":{"top_left_x":322,"top_left_y":335,"width":1313,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a16cec4ad3f149bfaed731e93a97dfb3","type":"text","conversion_output":true,"text":"logarithmic link to estimate Risk Ratios with \\(95 \\%\\) Cls and p-values, or exact logistic","text_display":" logarithmic link to estimate Risk Ratios with \\(95 \\%\\) Cls and p-values, or exact logistic","confidence":0.8780979634002506,"confidence_rate":0.9986031580421562},{"cnt":[[322,382],[1794,382],[1794,428],[322,428]],"region":{"top_left_x":322,"top_left_y":382,"width":1472,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a2339c07c3a45af8544040cc8ff0440","type":"text","conversion_output":true,"text":"regression to approximate Risk ratios if the number of events in either arm is fewer than 10.","text_display":" regression to approximate Risk ratios if the number of events in either arm is fewer than 10.","confidence":0.95849609375,"confidence_rate":0.9995630873104178},{"cnt":[[322,430],[1768,430],[1768,475],[322,475]],"region":{"top_left_x":322,"top_left_y":429,"width":1447,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26df319c88df43b79530791189bdd995","type":"text","conversion_output":true,"text":"Should there be convergence difficulties with log-binomial regression, a log-Poisson model","text_display":" Should there be convergence difficulties with log-binomial regression, a log-Poisson model","confidence":0.99853515625,"confidence_rate":0.9999845694066055},{"cnt":[[322,477],[1057,477],[1057,522],[322,522]],"region":{"top_left_x":322,"top_left_y":476,"width":736,"height":47},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"565029903ef149d8aeea8e32c05d541d","type":"text","conversion_output":true,"text":"will be employed with robust standard errors.","text_display":" will be employed with robust standard errors.","confidence":1,"confidence_rate":1},{"cnt":[[322,524],[1721,524],[1721,569],[322,569]],"region":{"top_left_x":322,"top_left_y":524,"width":1399,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4445de58f4384b24a33b42da3c6f9d86","type":"text","conversion_output":true,"text":"Duration and length of stay outcomes \\((5,10,11)\\) will be summarised using medians and","text_display":"\nDuration and length of stay outcomes \\((5,10,11)\\) will be summarised using medians and","confidence":0.9946346282958984,"confidence_rate":0.999940882879314},{"cnt":[[322,574],[1751,574],[1751,621],[322,621]],"region":{"top_left_x":322,"top_left_y":573,"width":1429,"height":48},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b15959804b274d08927d5ee6762cc031","type":"text","conversion_output":true,"text":"interquartile ranges, and compared across treatment arms using the Wilcoxon- Breslow-","text_display":" interquartile ranges, and compared across treatment arms using the Wilcoxon- Breslow","confidence":1,"confidence_rate":1},{"cnt":[[322,623],[1734,623],[1734,668],[322,668]],"region":{"top_left_x":322,"top_left_y":623,"width":1412,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ef9816770bf4f8fa20c3bc2ca918944","type":"text","conversion_output":true,"text":"Gehan test, with length of stay in hospital and in intensive care censored at 30 days, and","text_display":"Gehan test, with length of stay in hospital and in intensive care censored at 30 days, and","confidence":0.9985356330871582,"confidence_rate":0.9999850466409257},{"cnt":[[322,670],[1261,670],[1261,715],[322,715]],"region":{"top_left_x":322,"top_left_y":670,"width":940,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50753bf147d148c3b278ee8beb7e7e1c","type":"text","conversion_output":true,"text":"with in-hospital deaths assigned the highest length of stay.","text_display":" with in-hospital deaths assigned the highest length of stay.","confidence":1,"confidence_rate":1},{"cnt":[[322,718],[1631,718],[1631,763],[322,763]],"region":{"top_left_x":322,"top_left_y":717,"width":1309,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38e80827db434c5faefbecc8abdf74ab","type":"text","conversion_output":true,"text":"Outcomes measured on a continuous or semi-continuous scale ( \\(6,7,8,12\\) ) will be","text_display":"\nOutcomes measured on a continuous or semi-continuous scale ( \\(6,7,8,12\\) ) will be","confidence":0.8394746468457015,"confidence_rate":0.9979907683032359},{"cnt":[[322,765],[1775,765],[1775,810],[322,810]],"region":{"top_left_x":322,"top_left_y":764,"width":1453,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73889db4eebe4ac9bfc5fe6d115f8b6a","type":"text","conversion_output":true,"text":"summarised by means and standard deviations if reasonably symmetrically distributed and","text_display":" summarised by means and standard deviations if reasonably symmetrically distributed and","confidence":1,"confidence_rate":1},{"cnt":[[322,812],[1723,812],[1723,857],[322,857]],"region":{"top_left_x":322,"top_left_y":812,"width":1402,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8969b4bb8a2c4a2eb51e6a6a3dd3e19a","type":"text","conversion_output":true,"text":"compared between treatment arms using linear regression with robust standard errors.","text_display":" compared between treatment arms using linear regression with robust standard errors.","confidence":1,"confidence_rate":1},{"cnt":[[322,859],[1742,859],[1742,904],[322,904]],"region":{"top_left_x":322,"top_left_y":859,"width":1421,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f67c1696651d47929ed67a3d565016ba","type":"text","conversion_output":true,"text":"Skewed outcomes will be summarised by medians and interquartile ranges; right skewed","text_display":" Skewed outcomes will be summarised by medians and interquartile ranges; right skewed","confidence":1,"confidence_rate":1},{"cnt":[[322,907],[1766,907],[1766,954],[322,954]],"region":{"top_left_x":322,"top_left_y":906,"width":1445,"height":48},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"edd3490808a94a1c869f3810746b571f","type":"text","conversion_output":true,"text":"outcomes will be log-transformed prior to analysis using linear regression, and left skewed","text_display":" outcomes will be log-transformed prior to analysis using linear regression, and left skewed","confidence":1,"confidence_rate":1},{"cnt":[[322,958],[1601,958],[1601,1003],[322,1003]],"region":{"top_left_x":322,"top_left_y":958,"width":1279,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10309affcea44819a6b527e89dc3f2e3","type":"text","conversion_output":true,"text":"outcomes will be analysed using median regression with robust standard errors.","text_display":" outcomes will be analysed using median regression with robust standard errors.","confidence":1,"confidence_rate":1},{"cnt":[[318,1001],[823,1001],[823,1053],[318,1053]],"region":{"top_left_x":317,"top_left_y":1001,"width":506,"height":52},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"899d77aaca7e40628a25e6837c6905cd","type":"section_header","conversion_output":false,"children_ids":["e8136ff89b644170a3784c802609afbe"],"text":"","text_display":""},{"cnt":[[322,1005],[819,1005],[819,1051],[322,1051]],"region":{"top_left_x":322,"top_left_y":1005,"width":497,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e8136ff89b644170a3784c802609afbe","type":"text","conversion_output":true,"parent_id":"899d77aaca7e40628a25e6837c6905cd","text":"Additional sensitivity analyses","text_display":"\n\n\\section*{Additional sensitivity analyses}","confidence":1,"confidence_rate":1},{"cnt":[[322,1053],[1772,1053],[1772,1098],[322,1098]],"region":{"top_left_x":322,"top_left_y":1052,"width":1451,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d1aa80092a94886bdfe19ba4a6a44a1","type":"text","conversion_output":true,"text":"Sensitivity analyses for all outcomes will use regression models with additional adjustment","text_display":"\n\nSensitivity analyses for all outcomes will use regression models with additional adjustment","confidence":1,"confidence_rate":1},{"cnt":[[320,1100],[1712,1100],[1712,1145],[320,1145]],"region":{"top_left_x":320,"top_left_y":1100,"width":1393,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ba0b098dfb245199044ddaf300eebd4","type":"text","conversion_output":true,"text":"for the stratification variables of site and planned HDU/ICU destination status, plus any","text_display":" for the stratification variables of site and planned HDU/ICU destination status, plus any","confidence":1,"confidence_rate":1},{"cnt":[[322,1147],[1553,1147],[1553,1192],[322,1192]],"region":{"top_left_x":322,"top_left_y":1147,"width":1232,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b556d72137d48228f232e89bc6f8a2a","type":"text","conversion_output":true,"text":"variables exhibiting substantial imbalance across treatment arms at baseline.","text_display":" variables exhibiting substantial imbalance across treatment arms at baseline.","confidence":1,"confidence_rate":1},{"cnt":[[320,1195],[1697,1195],[1697,1240],[320,1240]],"region":{"top_left_x":320,"top_left_y":1194,"width":1378,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9fac6ce1a1a74b85bb2b69b241a5aca0","type":"text","conversion_output":true,"text":"Sensitivity to missing outcome data will be performed using multiple imputation if the","text_display":" Sensitivity to missing outcome data will be performed using multiple imputation if the","confidence":1,"confidence_rate":1},{"cnt":[[322,1244],[1676,1244],[1676,1291],[322,1291]],"region":{"top_left_x":322,"top_left_y":1243,"width":1354,"height":49},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"473de773f8cb45cf8a59132be5442f99","type":"text","conversion_output":true,"text":"proportion of missing data for the particular outcome is \\(>5 \\%\\). These analyses will use","text_display":" proportion of missing data for the particular outcome is \\(>5 \\%\\). These analyses will use","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[322,1293],[1798,1293],[1798,1336],[322,1336]],"region":{"top_left_x":322,"top_left_y":1293,"width":1477,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d08d2cca213472a96414859932f7310","type":"text","conversion_output":true,"text":"multiple imputation, employing imputation models with baseline and auxiliary post-baseline","text_display":" multiple imputation, employing imputation models with baseline and auxiliary post-baseline","confidence":1,"confidence_rate":1},{"cnt":[[322,1341],[1442,1341],[1442,1386],[322,1386]],"region":{"top_left_x":322,"top_left_y":1340,"width":1120,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a8a48e21b574281ac9ecd3c490ddd2c","type":"text","conversion_output":true,"text":"variables, and results combined across imputations using Rubin's rule.","text_display":" variables, and results combined across imputations using Rubin's rule.","confidence":0.9990236759185791,"confidence_rate":0.9999869760715292},{"cnt":[[318,1384],[638,1384],[638,1437],[318,1437]],"region":{"top_left_x":317,"top_left_y":1383,"width":322,"height":55},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"880a6cdc5bfe465cb088bbe376660e90","type":"section_header","conversion_output":false,"children_ids":["2b4564588de34df9a6f9f610e4ab4a67"],"text":"","text_display":""},{"cnt":[[322,1388],[634,1388],[634,1433],[322,1433]],"region":{"top_left_x":322,"top_left_y":1387,"width":312,"height":47},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b4564588de34df9a6f9f610e4ab4a67","type":"text","conversion_output":true,"parent_id":"880a6cdc5bfe465cb088bbe376660e90","text":"Subgroup analyses","text_display":"\n\n\\section*{Subgroup analyses}","confidence":1,"confidence_rate":1},{"cnt":[[322,1435],[1738,1435],[1738,1480],[322,1480]],"region":{"top_left_x":322,"top_left_y":1435,"width":1417,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"308a9e8c93ad4ce59260f52152c64c92","type":"text","conversion_output":true,"text":"Planned subgroup analyses will assess heterogeneity of treatment effects of the primary","text_display":"\n\nPlanned subgroup analyses will assess heterogeneity of treatment effects of the primary","confidence":0.9990234375,"confidence_rate":0.9999893800602199},{"cnt":[[322,1482],[1732,1482],[1732,1528],[322,1528]],"region":{"top_left_x":322,"top_left_y":1482,"width":1410,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"465564fb26684e6685fe9a07e335b50c","type":"text","conversion_output":true,"text":"endpoint across patient sex, age groups (approximate quartiles), country, bowel surgery","text_display":" endpoint across patient sex, age groups (approximate quartiles), country, bowel surgery","confidence":1,"confidence_rate":1},{"cnt":[[322,1530],[1783,1530],[1783,1577],[322,1577]],"region":{"top_left_x":322,"top_left_y":1529,"width":1462,"height":48},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8f3914a5f624255affed9b628e11252","type":"text","conversion_output":true,"text":"(yes/no) and intraoperative use of any goal-directed techniques (yes/no). The latter include","text_display":" (yes/no) and intraoperative use of any goal-directed techniques (yes/no). The latter include","confidence":0.9790139198303223,"confidence_rate":0.9997813701077862},{"cnt":[[322,1577],[1699,1577],[1699,1624],[322,1624]],"region":{"top_left_x":322,"top_left_y":1576,"width":1378,"height":49},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53ba3f5f8ed346e3a76c3e93ffcf7668","type":"text","conversion_output":true,"text":"invasive or non-invasive cardiac output, stroke volume or pulse pressure variation and","text_display":" invasive or non-invasive cardiac output, stroke volume or pulse pressure variation and","confidence":1,"confidence_rate":1},{"cnt":[[322,1629],[1457,1629],[1457,1674],[322,1674]],"region":{"top_left_x":322,"top_left_y":1628,"width":1135,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"03dbb02e90864f248a529056f9068739","type":"text","conversion_output":true,"text":"oesophageal Doppler, but exclude central venous pressure monitoring.","text_display":" oesophageal Doppler, but exclude central venous pressure monitoring.","confidence":1,"confidence_rate":1},{"cnt":[[320,1676],[1691,1676],[1691,1721],[320,1721]],"region":{"top_left_x":320,"top_left_y":1675,"width":1371,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6732757fc35141da9e01970c7c149bdb","type":"text","conversion_output":true,"text":"Additional prespecified subgroups will be tested for heterogeneity of effect, and their","text_display":"\nAdditional prespecified subgroups will be tested for heterogeneity of effect, and their","confidence":1,"confidence_rate":1},{"cnt":[[322,1723],[1790,1723],[1790,1768],[322,1768]],"region":{"top_left_x":322,"top_left_y":1723,"width":1468,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94b2f285ccee423f96acb8397b57ff97","type":"text","conversion_output":true,"text":"results considered exploratory: BMI categories (defined as underweight <18.5, normal 18.5-","text_display":" results considered exploratory: BMI categories (defined as underweight <18.5, normal 18.5","confidence":0.936673344578594,"confidence_rate":0.9993115983634746},{"cnt":[[322,1770],[1747,1770],[1747,1815],[322,1815]],"region":{"top_left_x":322,"top_left_y":1770,"width":1425,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36bf5095460f414da3db813e858189d3","type":"text","conversion_output":true,"text":"25 , overweight \\(25-30\\), obese \\(30-35\\), super obese \\(>35\\) ), ASA physical status ( \\(1 / 2,3,4\\) ), pre-","text_display":"25 , overweight \\(25-30\\), obese \\(30-35\\), super obese \\(>35\\) ), ASA physical status ( \\(1 / 2,3,4\\) ), pre","confidence":0.7092014889208684,"confidence_rate":0.9968810956884537},{"cnt":[[322,1818],[1785,1818],[1785,1863],[322,1863]],"region":{"top_left_x":322,"top_left_y":1817,"width":1464,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aac9aed79c214d66b09df3ee309e78ca","type":"text","conversion_output":true,"text":"operative planned HDU/ICU destination status, duration of surgery (approximate quartiles),","text_display":"operative planned HDU/ICU destination status, duration of surgery (approximate quartiles),","confidence":1,"confidence_rate":1},{"cnt":[[322,1865],[1669,1865],[1669,1910],[322,1910]],"region":{"top_left_x":322,"top_left_y":1864,"width":1348,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4908065232c64ae982629c9c702265a0","type":"text","conversion_output":true,"text":"and pre-operative planned use of a goal directed device (excluding CVP monitoring).","text_display":" and pre-operative planned use of a goal directed device (excluding CVP monitoring).","confidence":1,"confidence_rate":1},{"cnt":[[320,1961],[320,1912],[1730,1914],[1729,1964]],"region":{"top_left_x":320,"top_left_y":1912,"width":1410,"height":52},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"437c05df48f448a8864d18a1f698aab1","type":"text","conversion_output":true,"text":"Additional analyses of the above subgroups will be performed for the endpoints of new-","text_display":"\nAdditional analyses of the above subgroups will be performed for the endpoints of new","confidence":0.9980475902557373,"confidence_rate":0.9999785242066455},{"cnt":[[322,1964],[1760,1964],[1760,2009],[322,2009]],"region":{"top_left_x":322,"top_left_y":1963,"width":1438,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a435484fb464ec4b2cad51393f1b24e","type":"text","conversion_output":true,"text":"onset disability, composite of 30 day mortality and septic complications, and acute kidney","text_display":"onset disability, composite of 30 day mortality and septic complications, and acute kidney","confidence":1,"confidence_rate":1},{"cnt":[[322,2011],[428,2011],[428,2056],[322,2056]],"region":{"top_left_x":322,"top_left_y":2010,"width":106,"height":47},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d8420faf0d994a3a9d1f2578c0261edf","type":"text","conversion_output":true,"text":"injury.","text_display":" injury.","confidence":1,"confidence_rate":1},{"cnt":[[322,2058],[1794,2058],[1794,2103],[322,2103]],"region":{"top_left_x":322,"top_left_y":2058,"width":1472,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d05244dac8c14d48ad85d2d12696e8b7","type":"text","conversion_output":true,"text":"For these analyses, we will undertake tests for interaction by adding treatment-by-covariate","text_display":"\nFor these analyses, we will undertake tests for interaction by adding treatment-by-covariate","confidence":1,"confidence_rate":1},{"cnt":[[320,2105],[1613,2105],[1613,2151],[320,2151]],"region":{"top_left_x":320,"top_left_y":2105,"width":1294,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f28cbce1ff349da9364d0074c21a49f","type":"text","conversion_output":true,"text":"terms to the regression models specified for the main analyses of each outcome.","text_display":" terms to the regression models specified for the main analyses of each outcome.","confidence":1,"confidence_rate":1},{"cnt":[[318,2153],[810,2153],[810,2194],[318,2194]],"region":{"top_left_x":317,"top_left_y":2152,"width":493,"height":42},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ff6492ed4834b81a2a0f1307a42bc81","type":"section_header","conversion_output":false,"children_ids":["df340d1e42a047aa828b743abdd96bea"],"text":"","text_display":""},{"cnt":[[322,2157],[806,2157],[806,2191],[322,2191]],"region":{"top_left_x":322,"top_left_y":2157,"width":484,"height":35},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df340d1e42a047aa828b743abdd96bea","type":"text","conversion_output":true,"parent_id":"1ff6492ed4834b81a2a0f1307a42bc81","text":"SAMPLE SIZE RE-ESTIMATION","text_display":"\n\n\\section*{SAMPLE SIZE RE-ESTIMATION}","confidence":1,"confidence_rate":1},{"cnt":[[320,2200],[1721,2200],[1721,2245],[320,2245]],"region":{"top_left_x":320,"top_left_y":2200,"width":1401,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"35b0284b1263461ebaeb795d3e65c659","type":"text","conversion_output":true,"text":"The original sample size calculation was as follows: Assuming a 12 month disability-free","text_display":"\n\nThe original sample size calculation was as follows: Assuming a 12 month disability-free","confidence":1,"confidence_rate":1},{"cnt":[[322,2247],[1725,2247],[1725,2295],[322,2295]],"region":{"top_left_x":322,"top_left_y":2247,"width":1404,"height":48},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc4e91d14310441fab8355cba710c1fe","type":"text","conversion_output":true,"text":"survival probability of \\(65 \\%, 2650\\) patients were required to detect a hazard ratio of 0.80","text_display":" survival probability of \\(65 \\%, 2650\\) patients were required to detect a hazard ratio of 0.80","confidence":0.9584426879882812,"confidence_rate":0.9995533049377116},{"cnt":[[322,2299],[1654,2299],[1654,2342],[322,2342]],"region":{"top_left_x":322,"top_left_y":2298,"width":1333,"height":44},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52d5cee0249945c1a5cd63d1594d5f28","type":"text","conversion_output":true,"text":"with \\(90 \\%\\) power using the Freedman method for the sample size for a log rank test.","text_display":" with \\(90 \\%\\) power using the Freedman method for the sample size for a log rank test.","confidence":0.99755859375,"confidence_rate":0.9999725353059057},{"cnt":[[322,2344],[1790,2344],[1790,2391],[322,2391]],"region":{"top_left_x":322,"top_left_y":2343,"width":1468,"height":49},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87ad2f62b97046ceb4ff9fe83dfedde2","type":"text","conversion_output":true,"text":"Correspondingly, 850 events were expected to be observed. The sample size was inflated to","text_display":" Correspondingly, 850 events were expected to be observed. The sample size was inflated to","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[322,2393],[1489,2393],[1489,2436],[322,2436]],"region":{"top_left_x":322,"top_left_y":2393,"width":1167,"height":44},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a816deda0c7d48a99a5c75e37b63e29f","type":"text","conversion_output":true,"text":"a total of 2800 patients to account for withdrawals and loss to follow-up.","text_display":" a total of 2800 patients to account for withdrawals and loss to follow-up.","confidence":0.99951171875,"confidence_rate":0.9999940439141021}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"8501b684-3e70-49a9-81f9-ab3940fd1a00-6","page":6,"lines":[{"cnt":[[318,236],[1740,236],[1740,288],[318,288]],"region":{"top_left_x":317,"top_left_y":236,"width":1424,"height":52},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5d7aa8dd1b947f38ae11eee5660d536","type":"text","conversion_output":true,"text":"A sample size reassessment of the assumed primary endpoint event rate was performed","text_display":"\n\nA sample size reassessment of the assumed primary endpoint event rate was performed","confidence":1,"confidence_rate":1},{"cnt":[[318,284],[1747,284],[1747,335],[318,335]],"region":{"top_left_x":317,"top_left_y":283,"width":1430,"height":53},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d140558c1b1342e0b9cf86a8ce5c1d50","type":"text","conversion_output":true,"text":"after 2578 patients had been randomised. At that time there were 300 primary endpoint","text_display":" after 2578 patients had been randomised. At that time there were 300 primary endpoint","confidence":1,"confidence_rate":1},{"cnt":[[318,331],[1781,331],[1781,382],[318,382]],"region":{"top_left_x":317,"top_left_y":330,"width":1465,"height":53},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62d03a6a93b14bdebc6599cc85392fc6","type":"text","conversion_output":true,"text":"events with a 12 month event rate of approximately \\(15 \\%\\). Increasing the target sample size","text_display":" events with a 12 month event rate of approximately \\(15 \\%\\). Increasing the target sample size","confidence":0.9990236759185791,"confidence_rate":0.9999903287497746},{"cnt":[[318,378],[1807,378],[1807,432],[318,432]],"region":{"top_left_x":317,"top_left_y":378,"width":1490,"height":54},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ea76d91ba4b456bb1a6ffda8e928165","type":"text","conversion_output":true,"text":"to 3000 patients under this same event rate was expected to yield approximately 380 events","text_display":" to 3000 patients under this same event rate was expected to yield approximately 380 events","confidence":1,"confidence_rate":1},{"cnt":[[318,425],[1199,425],[1199,477],[318,477]],"region":{"top_left_x":317,"top_left_y":425,"width":882,"height":52},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14c9c13eacce4773b3cf37b50b2339af","type":"text","conversion_output":true,"text":"and afford \\(80 \\%\\) power to detect a hazard ratio of 0.75 .","text_display":" and afford \\(80 \\%\\) power to detect a hazard ratio of 0.75 .","confidence":0.998535871389322,"confidence_rate":0.9999778002237774},{"cnt":[[314,468],[546,468],[546,531],[314,531]],"region":{"top_left_x":313,"top_left_y":468,"width":233,"height":63},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57c8988218f744a9b7ddfd6eb995b5a0","type":"section_header","conversion_output":false,"children_ids":["0668c41017c14c2aac4a3be2be9a82fe"],"text":"","text_display":""},{"cnt":[[320,477],[535,477],[535,522],[320,522]],"region":{"top_left_x":320,"top_left_y":476,"width":215,"height":47},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0668c41017c14c2aac4a3be2be9a82fe","type":"text","conversion_output":true,"parent_id":"57c8988218f744a9b7ddfd6eb995b5a0","text":"REFERENCES","text_display":"\n\n\\section*{REFERENCES}","confidence":1,"confidence_rate":1},{"cnt":[[378,537],[1725,537],[1725,591],[378,591]],"region":{"top_left_x":378,"top_left_y":537,"width":1348,"height":54},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7e3bb5de96b43639776d2c116f7b607","type":"text","conversion_output":true,"text":"1. Liu KD, Thompson BT, Ancukiewicz M, et al. Acute kidney injury in","text_display":"\n1. Liu KD, Thompson BT, Ancukiewicz M, et al. Acute kidney injury in","confidence":0.5348586542859266,"confidence_rate":0.9914646787817284},{"cnt":[[434,597],[1652,597],[1652,655],[434,655]],"region":{"top_left_x":433,"top_left_y":597,"width":1220,"height":59},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1efad46358394011b720706598e40ea9","type":"text","conversion_output":true,"text":"patients with acute lung injury: impact of fluid accumulation on","text_display":" patients with acute lung injury: impact of fluid accumulation on","confidence":0.99853515625,"confidence_rate":0.9999787550418731},{"cnt":[[438,660],[1768,660],[1768,718],[438,718]],"region":{"top_left_x":438,"top_left_y":659,"width":1331,"height":59},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2489442bcea0479696221e5357dbdac0","type":"text","conversion_output":true,"text":"classification of acute kidney injury and associated outcomes. Crit Care","text_display":" classification of acute kidney injury and associated outcomes. Crit Care","confidence":0.99951171875,"confidence_rate":0.9999936571565041},{"cnt":[[438,722],[879,722],[879,776],[438,776]],"region":{"top_left_x":438,"top_left_y":721,"width":441,"height":55},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"05c3193033644cd29bae6edda9d9109b","type":"text","conversion_output":true,"text":"Med 2011;39:2665-71","text_display":" Med 2011;39:2665-71","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]}]}

documents/10.1056_nejmoa1801946/DEDUP_NOTE.md

@@ -0,0 +1,3 @@
+# Identical source PDFs
+
+`protocol.pdf` and `sap.pdf` in this folder are **byte-identical** (sha256 `183f32449cd64fb5561bbd2ec8c459ebb1c2330540b3b8d6215391efc5d2f72f`).

documents/10.1056_nejmoa1802345/DEDUP_NOTE.md

@@ -0,0 +1,3 @@
+# Identical source PDFs
+
+`protocol.pdf` and `sap.pdf` in this folder are **byte-identical** (sha256 `f4f5acf371bd9167f411c1766a163af000ad71ab3128f604b957c41f5ad97d34`).