Datasets:

xuan-liu
/

ARIES-data

Tags:
License:
Dataset card Data Studio Files Files and versions
xet
Community
ARIES-data / halogenase /examples.csv
xuan-liu
Recreate ARIES reaction and model-ready data
93d3c6a verified 10 days ago
Raw History Blame Contribute Delete
375 kB
example_id,molecule_label,enzyme_sequence,canonical_substrate_smiles,mapped_substrate_smiles,site_template_smarts
aries-halogenase-19581e27de7ced00ff1c,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Nc1ccc2c(c1)CCCC2=O,Nc1ccc2c(c1)CCCC2=O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-6f4b6612125fb3a0daec,1,MLKNVVVVGGGTAGWMTASYLTAAFGDRIGVTLVESKRVGSIGVGEATFSTVRHFFEYLGLEEKEWMPACNATYKLAIRFENWREPGHHFYHPFERQRVVDGFPLTDWWLREPRSDRFDKDCFLVGTLCDDLKSPRQLNGELFEGGLGGRSAYRTTLAEQTTQFPYAYHFDATLVANYLRDYAVARGVKHVLDDVQDVALDDRGWISHVVTGESGNLTGDLFIDCTGFRSLLLGKALAEPFQSYQDSLPNDSAVALRVPQDMENRGLRPCTTATAQEAGWIWTIPLFDRIGTGYVYAGDYISPEEAERTLRAFVGPAAEHADANHIKMRIGRSNRHWVNNCVAVGLSSGFVEPLESTGIFFIQHAIEQLVKHFPDERWDDGLRTAYNKLVNNVMDGVREFLVVHYYAAKRQDNQYWKDAKTRPLPDGLAERLERWQTRLPDNESVFPHYHGFESYSYVCMLLGLGGLDLKSSPALGLMDAAPARHEFKLVGEQAAELARTLPTQYEYFAQLHRAR,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-35135aaa6cc23891b40c,1,MTNVPEKCQVLVIGGGPAGSYSASALAREGIDVVLLEAEKFPRYHIGESMLPSMRHFLKFIDAYDKWDAHGFNVKNGGAFRLNWSRPETYTDFIAAGGPGGYAWNVIRSEADELLFKHAAECGVKTFDDTKVASIEFAPSEDANPLGRPVSATWTRKDGTSGTLAMDYIVDASGRNGLISTKYLKNRTFNKGLRNVASWGYWKGGGVHGVGTHKEGAPYFEALKDASGWVWFIPLHNGTHSVGVVQNQEMATEKKRKMAEPSSKGFYLESLEFVPGIKDLLSNAELISEVKSASDWSYSASNYAFPGVRIAGDAGSFIDPFFSSGVHLALSGGLSAATTIAAAIRGDCDETVAASWHDKKTSESYTRFLLVVSSALKQIRSQDEPVISDFDEQSFERAFDLFRPIIQGQADADAKGKLTQAEMSKTVEFCFRAFAHVSFEEKEALVQKLKSLGHDADANDEANRKALDELEKHLTPEEQAILKTLKGRRMVRPEDSLNIDNFTLDSIDGLAPRLERGNLGLSPA,C[C@H](O)Cc1cc2cc(O)cc(O)c2c(=O)o1,C[C@H](O)Cc1cc2cc(O)cc(O)c2c(=O)o1,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2] || [O;D0+:1]>>[O;D1+:1]-[C;D1:2]
aries-halogenase-76a50887d8f1c2e93017,1,MKHGGMASGAIERVVIVGGGTAGWMAAAALGAYLAGAGTRITLIESSEIGTIGVGEATIPTIRRFYAALGMTDAEVMRACEATAKLGIRFVDWKPGTSFVHPFGRFGQDLRGIDFHQYWQKARQAGRAAPLEEYSLGAMLAREGHASVPLPNPPSQLSVFDWALHFDAARFAAHMRAYAERAGVARIDARITDVTLHGETGFIEAVTLDSGERVAGDLFVDCSGFRGLLIGEALGTPYRDWSHWLLCDGAFAVQSERVGEPPSCTTVTARTAGWQWRIPLRSREGNGLVFASDFQGDDEARAELLANIPGAPTMEPRRLRFTPGRREVAWARNCVSLGLASGFLEPLESTSIALIETGIERLKQLFPDKGFDPAVIAEYNAQSAEEMERVRDFILLHYHLSTRDGPFWQACREMTLPDSLAAKLELWRARGAFLRYRWEMFSPASWLAIYGGFEHLPERLDPGVAAVGTDELAQGLEQMRAAIARTVADTPTHSEFLATVDGAAAEPMRTSV,Fc1ccc2[nH]ccc2c1,Fc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-d59eced1ded07f84c145,1,MPFITVGQENSTSIDLYYEDHGAGQPVVLIHGFPLSGHSWERQSAALLDAGYRVITYDRRGFGQSSQPTTGYDYDTFAADLNTVLETLDLQDAVLVGFSMGTGEVARYVSSYGTARIAKVAFLASLEPFLLKTDDNPDGAAPKEFFDGIVAAVKADRYAFYTGFFNDFYNLDENLGTRISEEAVRNSWNTAASGGFFAAAAAPTTWYTDFRADIPRIDVPALILHGTGDRTLPIENTARVFHKALPSAEYVEVEGAPHGLLWTHAEEVNTALLAFLAK,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-2858dcd1057d3eae7f7d,1,MSVSGSERSAEGNRKKRVVIVGGGTAGWMTASYLTAAFGDRVDLTVVESAQIGTIGVGEATFSDIRHFFEFLRLEESDWMPECNATYKLAVRFENWREPGHHFYHPFEQMSSVDGFPLSDWWLRNPTTSRFDKDSFVMTSLCDAGVSPRYLDGSLIDQDFVEQERDDDSARSTIAEYQGAQFPYAYHFEAHLLAKYLTGYATRRGTRHIVDNVVDVALDERGWISHVRTEEHGDLEADLFVDCTGFRGLLLNKALGEPFVSYQDTLPNDSAVALQVPLDMEREPIRPCTTATAQEAGWIWTIPLISRVGTGYVYASDYTTPEQAERVLRDFVGPAAADVPANHIKMRIGRSRRSWVNNCVGVGLSSGFVEPLESTGIFFIHHAIEQIVKYFPSGGAGDDRLRELYNRSVGHVMDGVREFLVLHYRSAKRADNQYWKDTKTRTVPDSLAERIEFWKHKVPDAETVYPYYHGLPPYSYNCILLGMGGIDVNYSPALDWANEKAALAEFERIRVKAEKLVQELPTQNEYFAAMRAGR,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-6208ef0f7750c111548c,1,MSVEDFDVVVAGGGPGGSTVATLVAMQGHRVLLLEKEVFPRYQIGESLLPATVHGVCRMLGVADELAGAGFPIKRGGTFRWGARPEPWTFHFGISAKMAGSTSHAYQVERARFDEILLNNAKSKGVVVREGCSVHDVVEDGERVTGAKYTDPDGNEREVSARFVIDASGNKSRLYSKVGGSRNYSEFFRSLALFGYFEGGKRLPEPVSGNILSVAFDNGWFWYIPLSDTLTSVGAVVRREDADKIQGDREKALNALIAECPLISEYLSNATRVTTGKYGELRVRKDYSYQQETYWRPGMVLVGDAACFVDPVFSSGVHLATYSALLAARSINSVLAGDLDEKTALNEFEARYRREYGVFYEFLVSFYQMNVNEESYFWQAKKVTQNQSTDIESFVELIGGVSSGETALTAADRIAARSAEFAAAVDEMAGGDGDNMVPMFKSTVVKQAMQEAGQVQMKALLGEDAEPELPLFPGGLVTSPDGMKWLPHHPA,CC(C)C[C@H](C(=O)N[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)S)[C@H](O)c1ccc(O)cc1)c1ccc(O)cc1)c1ccc(O)cc1)[C@H](O)c1ccc(O)cc1)C(C)N,CC(C)C[C@H](C(=O)N[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)S)[C@H](O)c1ccc(O)cc1)c1ccc(O)cc1)c1ccc(O)cc1)[C@H](O)c1ccc(O)cc1)C(C)N,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-39fa9ec190eee7b6f4df,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIILNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-da4ea2a5506f2693eae1,1,MAIPQSCTVLVAGGGPGGSYTAAALAREGVDVVLLEADCHPRYHIGESLLPSMRYLLRFIDLEDTFEQHGFQKKLGAFFKLNAKSAGYTDFIRANGPNGYSWNVVRSESDEILFRHATKSGAKTFENVSLKSVNFEPYENDKFTSQDKLTNPGRPVSAEWKTKDGCSGTISFDYLVDATGRVGILSTKYLKNRKFNESFRNIAMWGYFKGNIPPSPGTDRENQPISEGMRDGSGWVWMLPLHNGTVSIGAVVRKDIFQAKKKALPEGTTEAQTLASLVALCPTISSYLEPAELASGIRQAADYSYSANAYAGPNFRIVGDAGCFIDPFFSSGHHLALSSALAAATSINACIRGDCNEFDASRWFAKKVDEGYTLFLVVVMAALKQIRMQEQPILSDLDEEGFDRAFTILRPVIQGAADKETAPKAKGESITETIDLCLTALNDLHDTELQRKLTSIVEAKGTPEQEQLLGKLSPDETAALHRMRAMHSILPMGELEDFENSNIDGFKARLEKGSLGLRRERALCRDHAGDLQM,Nc1cccc2[nH]ncc12,Nc1cccc2[nH]ncc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-a46e37632fa6ca51a13f,1,MSIPESCTVLVVGGGPAGSYTAAALAREGTDVVLLEADTFPRYHIGESMLASMRHFIRFIDLEKTFDNHGFRRKACYSHYNVYCDNDVLSDTDFLAVNGPNGYSWNVIRSESDKLMFDHAEKSGAHTFQGVKVDSVQFIPAPDFPADERICNPGQAVSATWSRKADGATGTIKFDYIVDASGRNGIISTQYLKNRKFNQALKNQANWGYWKGAKTYAPGTHMEGAPLFEALTDQSGWCWAIPLHDDTLSVGIVMRQDLSLARKRGLGSPSMIEFYKHCLTLAPEIEARLAEAELVSPTIKAASDWSYSASGYAGPNFRLVGDAGCFIDPYFSSGVHLALAGGLSAAMTIQASIRGDCSEFQAAKCHSARVGESYSRFLLVVMTALKQIRSGNEPVLSDFDEDGFDRAFSFFRPIIQGLADADASGKLTQGVISQSVEFCLHAFENISSEARQGVLDKLERVKADPNVETKADLEKLTEDELAILRTIRARQMLRGEEAMDGVKSFAQDVIDGWVPRLVHGSLGMDRVGDQVAAPKYQESVFESGLADKKPAPALEKRPEGVVQV,CC[C@H](C)/C=C/C(=O)Cc1cc(O)c(C)c(O)c1C=O,CC[C@H](C)/C=C/C(=O)Cc1cc(O)c(C)c(O)c1C=O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-1da51b8d8ff98f6a48f8,1,MTSSRRTSDSRFTLGRRSVLLGGSTAAAMTMLGLPHAAGAAGINGEPDPTFDFDLDTDNYIRWARPSTNDQATTPSVNEFVGSMDATLILWMAHVGAMAAFDAAAPYHETAVGVYARIPRRPSSESATNRNVNIALFHSQYRIFERMPLGGVDGPLGGLRDIMVALGLNPDDTSENLTSPVGIGNAAAKAVWNALKNDGFNVLGYEGGRKYNPQPWSDYTGYRPVNTPHELRNPSRWQPQLHAHNGRRVGGGHGDLGIYVAQHFVTPQAAVTKAHIFTDPAQFKLGPPSHSDHRRPRAYKQSVDEILEASATLTDERKALAEVMDNKSWGLGYSATAAAQNYEESHGELGVFDWVAWSLQHSLATFGAMVAAWHHKGLYDAVRPVSAVRHVYGRSKVTAWGGLGMGTVNDLPANEWVSYLPVADHPEFPSGSTTMCAAGAQAMRRYFDSEDLNWTLEFKAGRSLTEPGAVPAKDLKVHFATWSELNRVCAQSRVWGGVHFRGTVERSLVFGTQFGDLAHEFLQRHITGNVKDGAGS,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-6e4001871c0cf27c7634,1,MNVEQIDENLAKFLAERYTPESVAQLADRFHRFGFVKFDAANRLVPDELQTAVREECDLLIEQHKERRNLLLSTTGNTPRRMSVVKSEEIEKSELISTLSRSEVLLGFLAGITREEIIPEVSSDERYLITHQEFKSDTHGWHWGDYSFALNWALRMPPIEHGGMLQAVPHTHWDKSNPRINQTLCEREINTHGLESGDLYLLRTDTTLHRTVPLSEDSTRTILNMTWAAKRDLEKDLVGNDRWWENPEAEAARAVDNA,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D2:1]-[C;D2+:2]-[C;D2:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D2:3]
aries-halogenase-e3d6c4d4599e00882384,1,MSIPKSCEVLVAGGGPAGSYAASALAREGVDVVLLEADKHPRYHIGESMLPSIRPLLRFIDLEETFEKHGFQKKLGAAFKLTAKREGYTDFVAAHGPNGYSWNVVRSESDELLFKHAAKSGALTFQGVKVDSLEFEPYDSDFPSGGKVANPGRPVAARWSAKDGRSGTISFQYLVDATGRAGITSTKYLKNRKFNEGLKNLAIWGYYKGARPWAEGTPRENQPYFEGMRDGAGWCWTIPLHNGTVSVGAVLRSDLFFAKKKSLGEDVTNAMIMAECMKLCPTIKELLEPAELVSDIKQATDYSYSASAYAGPYFRIVGDAGCFIDPFFSSGHHLAMAGALAAAVSIRASMKGDCSEYEASNWHARKVDEGYTLFLLVVMAALKQIRMQEEPVLSDIDDDGFDRAFQFLKPVIQGSGSAEIVKRFTKKEVSEAIDFAVLALDNMAGAGEHANETNGSNGTGETNGDAKTLENITVEDEKVLSGIRILAKVAPSADMKDLEGTAIDGFMPRLEHGHLGLNRV,O=c1c(-c2ccc(O)cc2)coc2cc(O)ccc12,O=c1c(-c2ccc(O)cc2)coc2cc(O)ccc12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-28dae7c8bde2f3ca608f,1,MPYVTTKDNVEIFYKDWGPKDAQPIVFHHGWPLSGDDWDAQMLFFVQKGYRVIAHDRRGHGRSAQVSDGHDMDHYAADAFAVVEALDLRNAVHIGHSTGGGEVARYVANDGQPAGRVAKAVLVSAVPPLMLKTESNPEGLPIEVFDGFRKALADNRAQFFLDVPTGPFYGFNRAGATVHQGVIRNWWRQGMEGSAKAHYDGIKAFSETDQTEDLKSITVPTLVLHGEDDQIVPIADAALKSIKLLQNGTLKTYPGYSHGMLTVNADVLNADLLAFVQA,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-5d389f5e2e34c6b0bad9,1,MNNPDALRKVCIVGGGTAGWIAAAVMAHHMKGRLFEIELVESDDIGTIGVGESTIPPFMELIAKLDIDEQDFVRQVQASFKLGIEFKDWFRKDESYFHPFGDVGQRVELSDFYQCWRKATLAGHDFPLQDFAPATVMAHAGRFMLPFKARNTPIAGASYALHVDAKRVAQFLRGHAEARGVKRTEGIVTDVALDARGFVSTLTLKDGRTIDADFFIDCSGFRALLIEKALGSGYTDWSNYLFCDRAIAAQTENVGPPRPYTLAEAQDAGWRWRIPLQHRTGNGHVYSSEFMSDEEATRILLEKVEGEVVAGPMVVPFRTGVREKIWHRNVLAIGLSSGFIEPLESTAIHLIYRGMDFFFRFLPDRHCDPALADEYNRRMVADYTEIRDFIVLHYCTTARDDTPFWRKCRDMDWPDSLKERVELFRSNGTLREGLDELFRSVSWFSVLEGMGIRPRTYHPLVDRIDEAMLYAGLDKAREQLAGFVRQLPTQQQFIDAHCRAEKVDLTRPVMAGV,Cc1c[nH]c2ccccc12,Cc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-1d28c120568c10e19b9d,1,MNTRRQQAQNIRNNAAELAANRPHPQHINNKEEYEYRRPKKDGNEPSHIANFTKGLPHDEHTGLLLNSADYDQFVLGIQSGDTTDFARTPLGPAELPKVHGCLSKQKIDCDDDHRSGFWKSQIAQGAAGGDGAKLRAWESAGAGLVFDLEGPDAQAVTMPPAPRLESPELTSEIAEVYSQALLRDIHFSQLRDPGLGDQVNACDSCPTQLSIYEAIDILNTVQIEGQNWFSANCCDLTDDEQARQRPLVTRQNIFRGIAPGDDVGPYLSQFLLIGNNALGGGVFGQEAGHIGYGAIRIDQRVRKATPCKDFMTNFETWLDVQNGADLRGLETYVDADPGKCREFPAYRVITTPRDLATYVHYDALYEAYLNACLILLGMGAPFDPGIPFQKPDVEDKQQGFAHFGGPQILTLVCEAATRGLKAVRFQKFNVHRRLRPEALGGLVDRYKHGKGAGDELKPVAALVEALENVGLLSKVVAHNQLQNQNLDRSGDPSSAGDNYFLPMAFPEGSPMHPSYGAGHATVAGACVTMLKAFFDHGWQLNLGMANGKYISYEPNQDGSSLQQVLLDCPLTVEGELNKIAANISIGRDWAGVHYFTDYIESLRLGEKIAIGILEEQKLTYGENFTMTVPLYDGGSIQI,Cc1ccc(C(C)C)c(O)c1,Cc1ccc(C(C)C)c(O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-bb668ca95563216088b9,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,CNCCN1CCc2ccccc21,CNCCN1CCc2ccccc21,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-3d3286f7cd19074f04e5,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Nc1ccc(-c2nccs2)cc1,Nc1ccc(-c2nccs2)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-4a8596a7790b5ca9e067,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPSFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-01d54579da446ae1e75c,1,MSNNTISTKPALHFLDINATEVKKYPTAIQDIIINRSFDGMIIRGVFPRDTMEQVARCLEEGNDGGMKSILNKREEFGTKVLQIYGHAIPGQDPDLKDYFASSAIFRQACRTMFQGSPDFEEQVESIFHSLSELPVEIPTGPEGQTYTPATIRLLLEGREIAVHVGNDFLLMPAANHLKTLLDLSDQLSYFIPLTVPEAGGELVVYSLEWNPQEASKYAQMQEYMDDVESKIKSNQSQSVAYAPGPGDMLLFNGGRYYHRVSEVIGNSPRRTIGGFLAFSKQRNKIYYWS,C=C(C)[C@H]1CCC(C)(C)C(=O)[C@@H]1c1c[nH]c2ccccc12,C=C(C)[C@H]1CCC(C)(C)C(=O)[C@@H]1c1c[nH]c2ccccc12,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-61a229bae1e90331edd9,1,MKTITAEPRYYLSVEEKQFFQENGYIGPFTLFPPEEMLELWYGIKMDLLDKETAPFPNNKMNYDRHLDIKALNDIISHPKVVDRVSSILGPNVLCWRTEWFPKYPGDEGTDWHQAESFVEFEGESKLVPTESHDGPWELTAWVTFSEATRKNGCMKVMPGTHTTWYFDEHRNIKFEPDNINQKLTKGQKSGFYGYDYDKLKLDPNWEPDESQAVHLEMEPGQFFLFTSRCMHGSEPNTSESSIRYGWSTRFVSTDVRVYPDWDSFEHFGEKFMLDRYSTVLVAGEDTYKHNKVRQPL,C[C@H](CCl)C[C@H](N)C(=O)S,C[C@H](CCl)C[C@H](N)C(=O)S,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-2397346b45823e070f6f,1,MPYVTVGQENSATIDIYYEDLGAGQPIVLIHGFPLNGDSWEKQVLVLLNAGYRVITYDRRGFGASSQPSSGYDYDTFAADLHTLMTKLDLQNTVLVGFSMGTGEVTRYLGKYGSERVQKAVLMAPVPPFLLKTNDNPEGVDQSVFDGIMKAIVDDRPAYFSAFFKEFFNVDVLLGERISNEAIQASWNVAAGASAKGTLDCVPSWLTDFRDDLPRIDVPTLIIHGDADRILPLESTAARLPKRIKNSQLEIIPGGPHAINWTHADQVNPLLLNFLQ,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-b4bbe448fde336bb6a7d,1,MTTGHSPVSGFSPRRRSLLIGGASAAALLPLGHAGTAAAAEGGKAAQAEFDLDKDNYIEWFQPEDDGAGISPSSEIFGPMDVTVFLWINHLTGLGWFDAVAPYHETAVGVHSRIPRRPSSESATNRNMNIACIYSQYQLVKQVIPSRVKPMRDLLTSIGLDPDDDSMDPADPVGVGNIAGKSVFEALKNDGMNFLGHDGGRKYNPRPWADYTGYRPVNTAFDVVNPSRWQPQLQAHNGRRVGGGPGDLGIWVAQHFVTPQMRMVKPHIYADPREFTVPPPKHVDHTRPRDFKRSADEVLEASAALTDEQKAIAEVMDNKIWGIGHSALVIARKHDQNGELGVQGWAHFILEHLLATFDPLIAVWNEKTKYDAARPVTVIQHVYGKKKVTSWGGPGMGTVDDMPAGEWSSYLPVGDHPEYPSGSTTLCSAASQCARRYFGSDELDWKFTFPAGSTRTEPGVVPAKDIELHFPTWTDFTQKCGASRVWGGVHFRKTVETSIAFGEQFGDMAHEFVQKHIKGEVED,CC(C)=CCC/C(C)=C/CC/C(C)=C/C[C@@]1(O)C(O)=CC(=O)c2c(O)cc(O)cc21,CC(C)=CCC/C(C)=C/CC/C(C)=C/C[C@@]1(O)C(O)=CC(=O)c2c(O)cc(O)cc21,[C;D1+:1]=[C;D3:2]-[O;D1:3]>>[C;D2+:1](-[Cl;D1:4])=[C;D3:2]-[O;D1:3]
aries-halogenase-8bcbb4c131df56f7c790,1,MSVEDFDVVVAGGGPGGSTVATLVAMQGHRVLLLEKEVFPRYQIGESLLPATVHGVCRMLGISDELANAGFPIKRGGTFRWGARPEPWTFHFGISAKMAGSTSHAYQVERARFDEMLLNNAKRKGVVVREGCAVTDVVEDGERVTGARYTDPDGTEREVSARFVIDASGNKSRLYTKVGGSRNYSEFFRSLALFGYFEGGKRLPEPVSGNILSVAFDSGWFWYIPLSDTLTSVGAVVRREDAEKIQGDREKALNTLIAECPLISEYLADATRVTTGRYGELRVRKDYSYQQETYWRPGMILVGDAACFVDPVFSSGVHLATYSALLAARSINSVLAGDLDEKTALNEFELRYRREYGVFYEFLVSFYQMNVNEESYFWQAKKVTQNQSTDVESFVELIGGVSSGETALTAADRIAARSAEFAAAVDEMAGGDGDNMVPMFKSTVVQQAMQEAGQVQMKALLGEDAEPELPLFPGGLVTSPERMKWLPHHPA,N[C@@H](Cc1ccc(O)cc1)C(=O)S,N[C@@H](Cc1ccc(O)cc1)C(=O)S,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-4621c1d55fa4e86ce0da,1,MNKPIKNIVIVGGGTAGWMAASYLVRALQQQANITLIESAAIPRIGVGEATIPSLQKVFFDFLGIPEREWMPQVNGAFKAAIKFVNWRKSPDPSRDDHFYHLFGNVPNCDGVPLTHYWLRKREQGFQQPMEYACYPQPGALDGKLAPCLSDGTRQMSHAWHFDAHLVADFLKRWAVERGVNRVVDEVVDVRLNNRGYISNLLTKEGRTLEADLFIDCSGMRGLLINQALKEPFIDMSDYLLCDSAVASAVPNDDARDGVEPYTSSIAMNSGWTWKIPMLGRFGSGYVFSSHFTSRDQATADFLKLWGLSDNQPLNQIKFRVGRNKRAWVNNCVSIGLSSCFLEPLESTGIYFIYAALYQLVKHFPDTSFDPRLSDAFNAEIVHMFDDCRDFVQAHYFTTSRDDTPFWLANRHDLRLSDAIKEKVQRYKAGLPLTTTSFDDSTYYETFDYEFKNFWLNGNYYCIFAGLGMLPDRSLPLLQHRPESIEKAEAMFASIRREAERLRTSLPTNYDYLRSLRDGDAGLSRGQRGPKLAAQESL,Cc1ccc(C(N)=O)c(N)c1,Cc1ccc(C(N)=O)c(N)c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-0f4121d0ef1df4c86854,1,MNQYDVIIIGSGIAGALTGAVLAKSGLNVLILDSAQHPRFSVGEAATPESGFLLRLLSKRFDIPEIAYLSHPDKIIQHVGSSACGIKLGFSFAWHQENAPSSPDHLVAPPLKVPEAHLFRQDIDYFALMIALKHGAESRQNIKIESISLNDDGVEVALSNAAPVKAAFIIDAAAQGSPLSRQLGLRTTEGLATDTCSFFTHMLNVKSYEDALAPLSRTRSPIELFKSTLHHIFEEGWLWVIPFNNHPQGTNQLCSIGFQFNNAKYRPTEAPEIEFRKLLKKYPAIGEHFKDAVNAREWIYAPRINYRSVQNVGDRFCLLPQATGFIDPLFSRGLITTFESILRLAPKVLDAARSNRWQREQFIEVERHCLNAVATNDQLVSCSYEAFSDFHLWNVWHRVWLSGSNLGSAFLQKLLHDLEHSGDARQFDAALEAVRFPGCLSLDSPAYESLFRQSCQVMQQAREQARPVAETANALHELIKEHEAELLPLGYSRISNRFILKV,Oc1cccc(O)c1Cl,Oc1cccc(O)c1Cl,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-ea5b27556fbb134def2c,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,C[C@@H]1C/C=C/CC/C=C/C(=O)Cc2cc(O)cc(O)c2C(=O)O1,C[C@@H]1C/C=C/CC/C=C/C(=O)Cc2cc(O)cc(O)c2C(=O)O1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-27d719c754aacd492a6d,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPSGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNFWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-7cb676d57114874e00c5,1,MKTVEFLAYLNSLQINLWAENDKLRYRSPQGVMTPELLGKLKERKEQLIALLRQKAEDLGEAEVYDVVICGGGLAGLTLARQLKLQKLNISVIVLDKIARPLPEASFKVGESTVEVGAFYLANTLQLTDYFEEQHLVKLGLRYFFNNSATNFQDRPELGLSEFHLPNSYQIDRGKLENDLRAFNVEAGVELRENCLVNEIELAVGLQQHHKIVYTQDKGDHKKTNVIQARWVVDAMGRRRFLQKKLGLDKPNNAQFGAVWFRVEGRFDISDFVPSSEEKWHNRVPNKNRYYSTNHLCGEGYWVWTIPLSTGHTSIGIVARQDIHPLKTYYNYELAYQWLQKNEPTLAFHLADKQPEDFRKMPKYSYSSKQVFSYNRWACVGEAGTVPDPFYSPGTDNIGFGNSLTTQLITLDLEGKLTQEKVKDANHFYLSYSDGVTLNIQNAYNCLGNGMVMATKFIWDTLSGWTFSGLMMFNSIYLDQEFRTKVQQISSKFFPLSYRMQQLFKDWANQSLHRVNFEFIDYLAIPFVEELRSRNLRYNQTESEIIENYLSSLKLLEEVAQVMFHLALEDIMPEMLPKVSSNSWLNAWAISLNASKWESDGLFAPKSEPRNLDLIKQQLWEAIGK,N[C@@H](Cc1ccc(O)cc1)C(=O)S,N[C@@H](Cc1ccc(O)cc1)C(=O)S,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-f32828acecb4282c87ea,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-226f76b55acb49701e06,1,MNKPIKNIVIVGGGTAGWMAASYLVRALQQQANITLIESAAIPRIGVGEATIPSLQKVFFDFLGIPEREWMPQVNGAFKAAIKFVNWRKSPDPSRDDHFYHLFGNVPNCDGVPLTHYWLRKREQGFQQPMEYACYPQPGALDGKLAPCLSDGTRQMSHAWHFDAHLVADFLKRWAVERGVNRVVDEVVDVRLNNRGYISNLLTKEGRTLEADLFIDCSGMRGLLINQALKEPFIDMSDYLLCDSAVASAVPNDDARDGVEPYTSSIAMNSGWTWKIPMLGRFGSGYVFSSHFTSRDQATADFLKLWGLSDNQPLNQIKFRVGRNKRAWVNNCVSIGLSSCFLEPLESTGIYFIYAALYQLVKHFPDTSFDPRLSDAFNAEIVHMFDDCRDFVQAHYFTTSRDDTPFWLANRHDLRLSDAIKEKVQRYKAGLPLTTTSFDDSTYYETFDYEFKNFWLNGNYYCIFAGLGMLPDRSLPLLQHRPESIEKAEAMFASIRREAERLRTSLPTNYDYLRSLRDGDAGLSRGQRGPKLAAQESL,Nc1ccccc1C(=O)O,Nc1ccccc1C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-7104741a92e73eb6c5d6,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATHPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNCWNNSAYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-556d7dc3a115356350f1,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Nc1ccc2c(c1)C(=O)CCCC2,Nc1ccc2c(c1)C(=O)CCCC2,[C;D1+:1]=[O;D1+:2]>>[C;D1+:1]-[O;D1+:2] || [c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-5d8f6cce532a7aeb5719,1,MSIPKSCEVLVAGGGPAGSYAASALAREGVDVVLLEADKHPRYHIGESMLPSIRPLLRFIDLEETFEKHGFQKKLGAAFKLTAKREGYTDFVAAHGPNGYSWNVVRSESDELLFKHAAKSGALTFQGVKVDSLEFEPYDSDFPSGGKVANPGRPVAARWSAKDGRSGTISFQYLVDATGRAGITSTKYLKNRKFNEGLKNLAIWGYYKGARPWAEGTPRENQPYFEGMRDGAGWCWTIPLHNGTVSVGAVLRSDLFFAKKKSLGEDVTNAMIMAECMKLCPTIKELLEPAELVSDIKQATDYSYSASAYAGPYFRIVGDAGCFIDPFFSSGHHLAMAGALAAAVSIRASMKGDCSEYEASNWHARKVDEGYTLFLLVVMAALKQIRMQEEPVLSDIDDDGFDRAFQFLKPVIQGSGSAEIVKRFTKKEVSEAIDFAVLALDNMAGAGEHANETNGSNGTGETNGDAKTLENITVEDEKVLSGIRILAKVAPSADMKDLEGTAIDGFMPRLEHGHLGLNRV,O=c1cc(-c2ccccc2)oc2cc(O)ccc12,O=c1cc(-c2ccccc2)oc2cc(O)ccc12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-355d8c0ee4e5698eaed3,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMVINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)ccc1Oc1ccncc1,Cc1cc(N)ccc1Oc1ccncc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-8e6aee9efac8086ebac5,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATMPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPFGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-15a26c6fa5151c712acc,1,MIRSVVIVGGGTAGWMTASYLKAAFDDRIDVTLVESGNVRRIGVGEATFSTVRHFFDYLGLDEREWLPRCAGGYKLGIRFENWSEPGEYFYHPFERLRVVDGFNMAEWWLAVGDRRTSFSEACYLTHRLCEAKRAPRMLDGSLFASQVDESLGRSTLAEQRAQFPYAYHFDADEVARYLSEYAIARGVRHVVDDVQHVGQDERGWISGVHTKQHGEISGDLFVDCTGFRGLLINQTLGGRFQSFSDVLPNNRAVALRVPRENDEDMRPYTTATAMSAGWMWTIPLFKRDGNGYVYSDEFISPEEAERELRSTVAPGRDDLEANHIQMRIGRNERTWINNCVAVGLSAAFVEPLESTGIFFIQHAIEQLVKHFPGERWDPVLISAYNERMAHMVDGVKEFLVLHYKGAQREDTPYWKAAKTRAMPDGLARKLELSASHLLDEQTIYPYYHGFETYSWITMNLGLGIVPERPRPALLHMDPAPALAEFERLRREGDELIAALPSCYEYLASIQ,CCNC(=O)c1ccccc1N,CCNC(=O)c1ccccc1N,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-ab5e292db6495899871d,1,MSNNTVSTKPALHFLDINATEVKKYPTAIQDIIINRSFDGMIIRGVFPRDTMEQVARCLEEGNDGGMKSILNKNEEFGTKVAQIYGHAIVGQSPDLKDYFASSAIFRQACRTMFQGSPDFEEQVESIFHSLSELPVEIPTGPEGQTYTPATIRLLLEGREIAVHVGNDFLLMPAANHLKTLLDLSDQLSYFIPLTVPEAGGELVVYSLEWNPQEASKYAQMQEYMDDVESKIKSNQSQSVAYAPGPGDMLLFNGGRYYHRVSEVIGNSPRRTIGGFLAFSKQRDKIYYWS,OCCCC[C@@H]1Nc2ccccc2[C@H]2OCCC[C@@H]12,OCCCC[C@@H]1Nc2ccccc2[C@H]2OCCC[C@@H]12,[C;D2:1]-[C;D2+:2]-[C;D2:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D2:3]
aries-halogenase-a3af7b3808c4cf72478d,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFSLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSSYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,COc1ccc2c3c([nH]c2c1)C(C)NCC3,COc1ccc2c3c([nH]c2c1)C(C)NCC3,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-3c1b7053f0edd447b778,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O,N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-a73b320dc0d3a57c03f8,1,MSTHFLGKVKFDEARLAEDLSTLEVAEFSSAYSDFACGKWEACVLRNRTGMQEEDILVSHNAPALATPLSKSLPYLNELVETHFDCSAVRYTRIVRVSENACIIPHTGYLELEEPFTRLHLVLDTNSGCANTEEDKIFHMGLGEIWFLDAMLPHSAACFSKTPRLHLMIDFEATAFPESFLRNVEQPVTTRDMVDPRKELTDEVIEGILGFSIIISEANYREIVSILAKLHFFYKADCRSMYDWLKEICKRRGDPALIEKTASLERFFLGHREHGEVMTY,O=C(O)[C@@H]1CCCN1,O=C(O)[C@@H]1CCCN1,[C;D2:1]-[C;D2+:2]-[C;D3:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D3:3]
aries-halogenase-5092c37bcbc9f0fb33cb,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATMPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPFGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYYGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-0a1f1256f9bac68e8064,1,MNTRNPDKVVIVGGGTAGWMTASYLKKAFGERVSVTLVESGTIGTVGVGEATFSDIRHFFEFLDLREEEWMPACNATYKLAVRFQDWQRPGHHFYHPFEQMRSVDGFPLTDWWLQNGPTDRFDRDCFVMASLCDAGRSPRYLNGSLLQQEFDERAEEPAGLTMSEHQGKTQFPYAYHFEAALLAEFLSGYSKDRGVKHVVDEVLEVKLDDRGWISHVVTKEHGDIGGDLFVDCTGFRGVLLNQALGVPFVSYQDTLPNDSAVALQVPLDMEARGIPPYTRATAKEAGWIWTIPLIGRIGTGYVYAKDYCSPEEAERTLREFVGPEAADVEANHIRMRIGRSEQSWKNNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKHFPAGDWHPQLRAGYNSAVANVMDGVREFLVLHYLGAARNDTRYWKDTKTRAVPDALAERIERWKVQLPDSENVFPYYHGLPPYSYMAILLGTGAIGLRPSPALALADPAAAEKEFTAIRDRARFLVDTLPSQYEYFAAMGQRV,Nc1ccccc1C(=O)O,Nc1ccccc1C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-155d1cf609cedded2fbc,1,MNKPIKNIVIVGGGTAGWMAASYLVRALQQQANITLIESAAIPRIGVGEATIPSLQKVFFDFLGIPEREWMPQVNGAFKAAIKFVNWRKSPDPSRDDHFYHLFGNVPNCDGVPLTHYWLRKREQGFQQPMEYACYPQPGALDGKLAPCLSDGTRQMSHAWHFDAHLVADFLKRWAVERGVNRVVDEVVDVRLNNRGYISNLLTKEGRTLEADLFIDCSGMRGLLINQALKEPFIDMSDYLLCDSAVASAVPNDDARDGVEPYTSSIAMNSGWTWKIPMLGRFGSGYVFSSHFTSRDQATADFLKLWGLSDNQPLNQIKFRVGRNKRAWVNNCVSIGLSSCFLEPLESTGIYFIYAALYQLVKHFPDTSFDPRLSDAFNAEIVHMFDDCRDFVQAHYFTTSRDDTPFWLANRHDLRLSDAIKEKVQRYKAGLPLTTTSFDDSTYYETFDYEFKNFWLNGNYYCIFAGLGMLPDRSLPLLQHRPESIEKAEAMFASIRREAERLRTSLPTNYDYLRSLRDGDAGLSRGQRGPKLAAQESL,NC(=O)c1ccccc1N,NC(=O)c1ccccc1N,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-a4ecdd704d258aa841bb,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVHTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,CCCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CCCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-f626051bc94422f26f4b,1,MSKKFALTAEQRASFEKNGFIGPFDAYSPEEMKETWKRTRLRLLDRSAAAYQDLDAISGGTNIANYDRHLDDDFLASHICRPEICDRVESILGPNVLCWRTEFFPKYPGDEGTDWHQADTFANASGKPQIIWPENEEFGGTITVWTAFTDANIANGCLQFIPGTQNSMNYDETKRMTYEPDANNSVVKDGVRRGFFGYDYRQLQIDENWKPDEASAVPMQMKAGQFIIFWSTLMHASYPHSGESQEMRMGFASRYVPSFVHVYPDSDHIEEYGGRISLEKYGAVQVIGDETPEYNRLVTHTTRGKKFEAV,CC(O)C(N)C(=O)S,CC(O)C(N)C(=O)S,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-06de973bb45531d52cdb,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,O=C(Nc1ccccc1)c1ccc[nH]1,O=C(Nc1ccccc1)c1ccc[nH]1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-826e27285307a923759d,1,MYDVVICGGGLAGLSLARQLKMTMPELSVLILEKTSGEVPVSPYKVGESLDETSNFYLSNILQLESYLQEHQLHKLGLRWFFGGGNLPLETRPEIGPPEFPSIRARHVDRKALENHLVQLNKESGVAHFTGVLVKDILLSEDDSPHEVLYTQQGGNHFTVKCRWLVDATGRRRYLQSKLNLTQPSGHRANAVWWQLEGKHSLDKMADDADWLSRNNHQRWFSTNHLMGDGYWVWVIPLITGNTSIGIVAAEEMHPLSKHSNYQSAMKWLEEHEPHFAKFIQTSTAQNFLAVKDFCYHSQQVFSEKRWSCVGDSAIFTDPFYSPGVVMLAYSNCLTVKMIELDHQNQLTAEIVQQFNNLLLRDIGHNYLQIYQDNYPVFGSFNVMSIKLFWDAVYIWFFPGALFFQQHFTNLEVLSNFSRIAQRYLALNQRVQKLFQDWGQAIKSQNFPCFLAYDISYKPTCLGKPRANGKRFFFDIFKEAHFSLVEKKDTQQYLADLEVQMQELEIWAQVIFRHALNQVMPERLSQFPEPFWVNVWAIGLNPEKWEEDRLFQPETEPQVDLRNYILAELPDDHYPPGAEPVTTSSVDNPAYVAAVN,Brc1ccc2[nH]ccc2c1,Brc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-3a8f6d79cd434dc10588,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLARHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-200dd69b70a88134b3a9,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYRGNFEEEFRNPWSNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-86b700fab5db37977a73,1,MSNNTISTKPALHFLDINATEVKKYPTAIQDIIINRSFDGMIIRGVFPRDTMEQVARCLEEGNDGGMKSILNKNEEFGTKVAQIYGHAIVGQSPDLKDYFASSAIFRQACRTMFQGSPDFEEQVESIFHSLSGLPVEIPTGPEGQTYTPATIRLLLEGREIAVHVGNDFLLMPAANHLKTLLDLSDQLSYFIPLTVPEAGGELVVYNLEWNPQEVDKSADLHKYIDEVESKFKSNQSQSVAYAPGPGDMLLFNGGRYYHRVSEVIGNSPRRTIGGFLAFSKERNKIYYWS,C=C[C@]1(C)CC[C@](C)(C(=C)C)[C@@H](Cc2c[nH]c3ccccc23)[C@H]1NC,C=C[C@]1(C)CC[C@](C)(C(=C)C)[C@@H](Cc2c[nH]c3ccccc23)[C@H]1NC,[C;D2:1]-[C;D2+:2]-[C;D4:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D4:3]
aries-halogenase-cbd02d97b0731d88c78d,1,MSIPKSCEVLVAGGGPAGSYAASALAREGVDVVLLEADKHPRYHIGESMLPSIRPLLRFIDLEETFEKHGFQKKLGAAFKLTAKREGYTDFVAAHGPNGYSWNVVRSESDELLFKHAAKSGALTFQGVKVDSLEFEPYDSDFPSGGKVANPGRPVAARWSAKDGRSGTISFQYLVDATGRAGITSTKYLKNRKFNEGLKNLAIWGYYKGARPWAEGTPRENQPYFEGMRDGAGWCWTIPLHNGTVSVGAVLRSDLFFAKKKSLGEDVTNAMIMAECMKLCPTIKELLEPAELVSDIKQATDYSYSASAYAGPYFRIVGDAGCFIDPFFSSGHHLAMAGALAAAVSIRASMKGDCSEYEASNWHARKVDEGYTLFLLVVMAALKQIRMQEEPVLSDIDDDGFDRAFQFLKPVIQGSGSAEIVKRFTKKEVSEAIDFAVLALDNMAGAGEHANETNGSNGTGETNGDAKTLENITVEDEKVLSGIRILAKVAPSADMKDLEGTAIDGFMPRLEHGHLGLNRV,O=c1cc(C(F)(F)F)c2ccc(O)cc2o1,O=c1cc(C(F)(F)F)c2ccc(O)cc2o1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-560aa3e6e94314c78236,1,MPICTTRDGVEIFYKDWGQGRPVVFIHGWPLNGDAWQDQLKAVVDAGYRGIAHDRRGHGHSTPVWDGYDFDTFADDLNDLLTDLDLRDVTLVAHSMGGGELARYVGRHGTGRLRSAVLLSAIPPVMIKSDKNPDGVPDEVFDALKNGVLTERSQFWKDTAEGFFSANRPGNKVTQGNKDAFWYMAMAQTIEGGVRCVDAFGYTDFTEDLKKFDIPTLVVHGDDDQVVPIDATGRKSAQIIPNAELKVYEGSSHGIAMVPGDKEKFNRDLLEFLNK,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-f138665c5aa660080145,1,MHAPAPSESQRLVRRVVIAGGGTAGWMAAAALSKLLGRQLQITLVESDEIGTVGVGEATIPSLVTFHRLLEIDEAQFMAATQATFKVGIAFEHWRDVDRHYIHSFGHTGTDHWSAGFQHFWLKAHARGVARDFGDYCLELRAAQEGRFAHLPNGGMNYAYHLDAGLYARFLRRFSEGFGVQRIEGRIGSVQTDAHSGDIAALVLDDGTRIEGDLFLDCTGFRALLIGQTLGVGSEDWSRWLFADSALAVQTESVGAPVTFTRARADRAGWMWRIPLQHRVGNGIVYSSRYTDQDSAAQVLEHNLQGRALTTPRALRFTPNQRHRVWEKNCVALGLASGFLEPIESTNIHLIQRGIVRLLQTFPQVIDPVDIAEYNRQAAEEIAHIRDFVILHYHATDRRDTAFWRDCASMEIPDSLRHRMELFRQSGRVFHQGNELFAENSWIQVMLGQGIVPRHHHPVADLMGDAELSQFLEGIRQRVEATLARLPPHAEFLRRYCPAPAPPAPMPQPAPGTPLAAPAA,Oc1ccccc1,Oc1ccccc1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-5344c4110f483793dc35,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMVINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Nc1ccc2c(c1)CCCC2=O,Nc1ccc2c(c1)CCCC2=O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-ecac903ea62dc1d5446a,1,MKIESVAIVGGGSSGWMTAAALSKLCPQLEIALIEDPNIKTVGVGESTLGHFNKFLHLLDLKDEDWMPACNATYKNSIRFTNFREGKGEVFEYPFGPSLDVSFFSQTDGINTWGKLANKYPEDFPPETFARFVNSNTYLAEHNRLTRNKDNKIPNFNFDWDTAYHIDAELFGQYLKEKIALPNGVKHIQGKVTGYQKESPNNHNFKYIILDQETAIFADLYIDCTGFKSLLLGEFMGEAFSPFSKKLANDKAMATRIPYENREEEMHNVTDCHAMKNGWVWNIPLWNRIGTGYCYSSRFVSKDDAEAEFREHLGERGKDAKIFHIDIGHGKRTRAWVNNCVGIGLSYGFIEPLESTGLLTTHENIENLVYLINQRDGYVTQAERDGFNYTCDHQIDSFSDFVAMHYAYSMRTDTPYWKWCTQMCNYMPESMGPHRQKQSTWQDLSTDTIGLNTWHINHNGISFIIAGHGLRPQSYDKLSEVLLKRNNESDYYYEDIRKDWLKHYESMVEYVKTLPTHYEFLRDEIYGSAE,NC(=O)c1ccccc1N,NC(=O)c1ccccc1N,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-39700d452c77592c9710,1,MTQARIRKVVIAGGGTAGWVAAAALAHQFRGLLEIVLVESEQIGTIGVGESTVPPIRAFHRFLQIDEQEFLRAVAGTFKLAISFEDWQGQGDRYIHPFGSTGQGTLVCAFHHFWLEAQRRGMHSGFDEYCLEAQAARADRFAVLQQPAVNYAYHLDAGLYARFLRTHAQRYGATRIEGKIQQVRQHADSGFVEALVLEDGQVVEGDLFIDCTGFRGLLIEQTLHTGYEDWSHWLPCDRAVAVQTESVEPPVPYTRAIAHAAGWRWQIPLQHRVGNGLVYARAHLSDDEASAMLLAAVQGTPRRDPMLVPFVTGRRLQTWNKNVVALGLASGFVEPLESTSIHLAIVAVMRLITLFPADGIAQPQVDLFNRISRAEAEHVRDFVILHYHATQREEALWRQCRAMELPESLQLRLRAWREGAHAWQDGDELFRVDSWTHVLLGQRVAPAQHHPLTRALPDQHLQQLLDGIRQPLQHVVTQLPTQQAFIDSYCKVDQSTWG,c1ccc2[nH]ccc2c1,c1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-72933e3b31f0070af647,1,MIRSVVIVGGGTAGWMTASYLKAAFDDRIDVTLVESGNVRRIGVGEATFSTVRHFFDYLGLDEREWLPRCAGGYKLGIRFENWSEPGEYFYHPFERLRVVDGFNMAEWWLAVGDRRTSFSEACYLTHRLCEAKRAPRMLDGSLFASQVDESLGRSTLAEQRAQFPYAYHFDADEVARYLSEYAIARGVRHVVDDVQHVGQDERGWISGVHTKQHGEISGDLFVDCTGFRGLLINQTLGGRFQSFSDVLPNNRAVALRVPRENDEDMRPYTTATAMSAGWMWTIPLFKRDGNGYVYSDEFISPEEAERELRSTVAPGRDDLEANHIQMRIGRNERTWINNCVAVGLSAAFVEPLESTGIFFIQHAIEQLVKHFPGERWDPVLISAYNERMAHMVDGVKEFLVLHYKGAQREDTPYWKAAKTRAMPDGLARKLELSASHLLDEQTIYPYYHGFETYSWITMNLGLGIVPERPRPALLHMDPAPALAEFERLRREGDELIAALPSCYEYLASIQ,Cc1ccc(C(N)=O)c(N)c1,Cc1ccc(C(N)=O)c(N)c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-fb8a0d2da8683cec6cc6,1,MSEQTSSLVIEVMEQQLAKHFQAILQDENRMKQIRNEFRRDGYFNFKNFSFLPKRILENVHAEVHALLDEYSVRRDVTVPSTGNTYRKMYNVNQPEIAEGGTFIPALYQSESLRKFLGNIAGDDLASCWEQEQYLVTKLSHPGDTHGWHWGDYPYTMIWIIEAPEDPAIGGVLQCVPHSEWDKQNPQIWQYILNNPIKSYHHLKGDVYFLKSDTTLHHVVPIQQETTRIILNTCWASAHDRRTDVAHESIEVIWDTKARTTEEA,NCCCC(N)C(=O)O,NCCCC(N)C(=O)O,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-5ef6514ed3304cf62b95,1,MGIPADNLQSRAKASFDTRVSAAELALARGSVPSFANGEELLYRNPDPDNDDPSFIASFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIADLTLGPARDPDTGLPIWRSDLANSLELEVRGWENSSAGLTFDLEGPDAQSIAMPPAPVLTSPELVAEIAELYLMALGREIEFSEFDSPKNAEYIQFAIDQLNGLEWFNTPAKLGDPPAKIRRRRGEVTVGNLFRGILPGSEVGPYLSQYIIVGSKQIGSATVGSKTLVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLDVQDAADFRGFESYEPGARLIRTIRDLATWVHFDALYEAYLNACLILLANRVPFDPNIPFQQEGKLDNQDVFVNFGDAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKIAAEKGESIFPEVDLAVEELGDILEKAEISNRKQNIADGDPDPDPSFLLPMAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDSNFQIDQVFEVDKDEDKLVKSSFKGTLTVAGELNKLADNIAIGRNMAGVHYFSDQFESLLLGEQVAIGILEEQSLTYGENFFFNLPKFDGTTIQI,CC(C)=CCC/C(C)=C\CO,CC(C)=CCC/C(C)=C\CO,[C;D1+:1]=[C;D1+:2].[O;D0+:3]>>[C;D2+:1](-[Br;D1:4])-[C;D2+:2]-[O;D1+:3]
aries-halogenase-8def3488486c17dfbc28,1,MSPSFVILGGGTAGWITAHLLERAWPDATITVVESPEIGTIGVGEGSTPSLKRFFEIIGAAEADWMPRCGATYKAGIRFVDWSPAAPWRDYRHPFTTQIDVHTEDAFILNCRNRRLGHDVPVRPDDFLLNGVLSAKGLAPVAPPNFPFRIEYGYHFDAGLLGQYLRELAVTRGVVHRPATVTTVRRAENGDIAALVTDREETIAGDIFVDCSGFNGLLIERTLGVPFHSFKDNLFNDAAVVVPTEMTGRPPVETVATALSNGWCWSIPLRHRVGNGYVYARDCQSPDAAETELRRTLGVSDAVPARHLTFRVGQVARHWERNCVAVGLSQGFIEPLEATALHLVLGTVEQFIRHYRDGGCTDRHRAAFNTVAAERMDGVRDYIVAHYKLNTRTDTDYWRANAANEALSDPLLHILDRWFRRGDIAEELARQGQRSHFGTLSWHCLLAGYGAFPPVSEARRDDMDFYAARRVGAFLEGCSRNFAPA,COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12,COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-84f01dd97c687fb28a29,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLEGSGIYFIYAAIHMLALHFPDKTFDKVLVDRFNREVEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-68e476b5d5aeca7b0e3b,1,MTASYLKAAFGDRIDITLVESGHIGAVGVGEATFSDIRHFFEFLGLKEKDWMPACNATYKLAVRFENWREKGHYFYHPFEQMRSVNGFPLTDWWLKQGPTDRFDKDCFVMASVIDAGLSPRHQDGTLIDQPFDEGADEMQGLTMSEHQGKTQFPYAYQFEAALLAKYLTKYSVERGVKHIVDDVREVSLDDRGWITGVRTGEHGDLTGDLFIDCTGFRGLLLNQALEEPFISYQDTLPNDSAVALQVPMDMERRGILPCTTATAQDAGWIWTIPLTGRVGTGYVYAKDYLSPEEAERTLREFVGPAAADVEANHIRMRIGRSRNSWVKNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKNFPAADWNSMHRDLYNSAVSHVMDGVREFLVLHYVAAKRNDTQYWRDTKTRKIPDSLAERIEKWKVQLPDSETVYPYYHGLPPYSYMCILLGMGGIELKPSPALALADGGAAQREFEQIRNKTQRLTEVLPKAYDYFTQLR,Cn1cc(C[C@H](N)C(=O)O)c2ccccc21,Cn1cc(C[C@H](N)C(=O)O)c2ccccc21,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-04edd1d7736883194af3,1,MEEQVPSSANILVIGGGPAGSYAATVLAREGFEVILLEKDVFPRYHIGESMLPSCRPFLKFIDCEEKLKNHGFTMKPGAAVKLNQYKREGYTDFISTNPDNAARNVVRSEFDELLLRHASEMGVHVYEGVRVEEIHFAPDEPTRPISLTWSKEDKTRGTVSFNWLVDASGRNGLMSTRYLKNRTFNKTLRNVAVWGYWTGTSCYAPGTTRENAPWFEALIDETGWAWFIPLHNGTTSVGVVLVEEESKRKKSQYRSECKDKSPSEIQHDCYMADLQRAPGLIQLLGTATFEGKLMSAGDYSYHATEYAGSNFRLAGDAGAFIDPFFSSGIHLALTGGLSAASTIAASIRGDCTESEACGFHNSKVGTAYTRFLLVVLGVYKQIRSQETAVLYDVDEDNFDKAFHFLRPVIQGCADADEGLTEAELQSTLDFCTNVFAPTQPETHEAAIQRLGSLADPDGPLLDTDTIDKLTGTDMEAKHALWKINARKPLHSMYDCKRNFGTEIINGFYVKMEQGVLGLVRT,Cc1cc(O)cc(O)c1C(=O)O[C@@H]1C[C@]2(C)[C@H]3CC(C)(C)C[C@H]3C=C(CO)[C@]12O,Cc1cc(O)cc(O)c1C(=O)O[C@@H]1C[C@]2(C)[C@H]3CC(C)(C)C[C@H]3C=C(CO)[C@]12O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-97a6d21df7c51e8289ac,1,MNQYDVIIIGSGIAGALTGAVLAKSGLNVLILDSAQHPRFSVGEAATPESGFLLRLLSKRFDIPEIAYLSHPDKIIQHVGSSACGIKLGFSFAWHQENAPSSPDHLVAPPLKVPEAHLFRQDIDYFALMIALKHGAESRQNIKIESISLNDDGVEVALSNAAPVKAAFIIDAAAQGSPLSRQLGLRTTEGLATDTCSFFTHMLNVKSYEDALAPLSRTRSPIELFKSTLHHIFEEGWLWVIPFNNHPQGTNQLCSIGFQFNNAKYRPTEAPEIEFRKLLKKYPAIGEHFKDAVNAREWIYAPRINYRSVQNVGDRFCLLPQATGFIDPLFSRGLITTFESILRLAPKVLDAARSNRWQREQFIEVERHCLNAVATNDQLVSCSYEAFSDFHLWNVWHRVWLSGSNLGSAFLQKLLHDLEHSGDARQFDAALEAVRFPGCLSLDSPAYESLFRQSCQVMQQAREQARPVAETANALHELIKEHEAELLPLGYSRISNRFILKV,Nc1cccc(N)c1,Nc1cccc(N)c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-085b2a38876eeddc33e3,1,MKKILIALISFAFAVSCKAPQKEEPINITPEELDASIDRVTEIMIHDIFSPPVASRIFAYPNVAAYEIVAATNDNYNSLAGQLNGLTAIPEPDTTKTINYELAAVVAHMELSKRLIFSEDRMESLRDSLYMVWEGKNPVLFSDSKAYGLQVADHIGEWMNKDNYAQTRTMPKFTVDADDPGRWQPTPPAYMDGIEPHWNKIRPFVLDSAAQFKPVPPPAYSLEEDSAFYKELKEVYDVRNKITEEGDSSEEIQIARFWDCNPYVSVTRGHLMFATKKITPGAHWMGIAKIAARKTNSDFAKTLFAYTKASVAMADAFISCWDEKYRSNLIRPETVINQHIDDSWKPVLQTPPFPEYTSGHSVVSGAASVVLTEVFGDNFSFDDDTEVPYGLPIRSFKSFKQAADEAAISRMYGGIHYRAAIEVGVKQGRDLGTFVVNKLHMLSDKKVAQN,CC1=CC(=O)C(C(C)C)=CC1C(c1cc(C(C)C)c(O)cc1C)c1ccccc1CS(=O)(=O)O,CC1=CC(=O)C(C(C)C)=CC1C(c1cc(C(C)C)c(O)cc1C)c1ccccc1CS(=O)(=O)O,[C;D1+:1]=[C;D3:2]>>[C;D2+:1](-[I;D1:3])=[C;D3:2] || [c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-de0023e398111d434248,1,MDDNRIRSILVLGGGTAGWMSACYLSKALGPGVEVTVLEAPSISRIRVGEATIPNLHKVFFDFLGIAEDEWMRECNASYKAAVRFVNWRTPGDGQATPRRRPDGRPDHFDHLFGQLPEHENLPLSQYWAHRRLNGLTDEPFDRSCYVQPELLDRKLSPRLMDGTKLASYAWHFDADLVADFLCRFAVQKLNVTHVQDVFTHADLDQRGHITAVNTESGRTLAADLFIDCSGFRSVLMGKVMQEPFLDMSKHLLNDRAVALMLPHDDEKVGIEPYTSSLAMRSGWSWKIPLLGRFGSGYVYSSQFTSQDEAAEELCRMWDVDPAEQTFNNVRFRVGRSRRAWVRNCVAIGVSAMFVEPLESTGLYFSYASLYQLVKHFPDKRFRPILADRFNREVATMYDDTRDFLQAHFSLSPRDDSEFWRACKELPFADGFAEKVEMYRAGLPVELPVTIDDGHYYGNFEAEFRNFWTNSNYYCIFAGLGFLPEHPLPVLEFRPEAVDRAEPVFAAVRRRTEELVATAPTMQAYLRRLHQGT,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-085bcb597bbd610a7f0f,1,MKIESVAIVGGGSSGWMTAAALSKLCPQLEIALIEDPNIKTVGVGESTLGHFNKFLHLLDLKDEDWMPACNATYKNSIRFTNFREGKGEVFEYPFGPSLDVSFFSQTDGINTWGKLANKYPEDFPPETFARFVNSNTYLAEHNRLTRNKDNKIPNFNFDWDTAYHIDAELFGQYLKEKIALPNGVKHIQGKVTGYQKESPNNHNFKYIILDQETAIFADLYIDCTGFKSLLLGEFMGEAFSPFSKKLANDKAMATRIPYENREEEMHNVTDCHAMKNGWVWNIPLWNRIGTGYCYSSRFVSKDDAEAEFREHLGERGKDAKIFHIDIGHGKRTRAWVNNCVGIGLSYGFIEPLESTGLLTTHENIENLVYLINQRDGYVTQAERDGFNYTCDHQIDSFSDFVAMHYAYSMRTDTPYWKWCTQMCNYMPESMGPHRQKQSTWQDLSTDTIGLNTWHINHNGISFIIAGHGLRPQSYDKLSEVLLKRNNESDYYYEDIRKDWLKHYESMVEYVKTLPTHYEFLRDEIYGSAE,Oc1ccc(-n2ccnc2)cc1,Oc1ccc(-n2ccnc2)cc1,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-c403741c4121989ac12c,1,MKLRIFGAVVLVFLTLQSCSDDEVTLPEVLEPSDIAFNQITVSNPTTQLVSDWTNLWLEIDQYAYGMRPTATSRALAYIHLAGYETAVFSMDGYVSNASNLNGLTINNSERASNVSLNVALNTCYSLVFDHFMYNVQADYDAKITQYRDAQEEQLVEGLSAETIANSKSWGAYVAQQIIAYSQTDTAAESQITDPQPFSYEPPVGEGYWTYSADEERAWFPYWDQARTFIISSEETTTVAPPVAYSTEVGSEFYTQMMDVYTTNNTAREDNNEDLWIAEFWSDDVEGLMTSPPGHQVSIANQLIGQYDTSPTASLVLLLKLGFSLNDAAVSTWADKYEYMVMRPSVYIQEYIDPTYETNLYRFINWPNPSFPGYPSGHSAFASAAAGVFIGAFGNDINFTDRSHEGRTEFRGAPRQFTSFTDMAQENGYSRIPLGVHIEMDCTEGLRLGYEVSDAVNAYNLTN,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-a3aaf5a0e9ad2901ab35,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATMPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-fcf1e4bf9cc9c1083647,1,MTQVIVVGGGPAGSTAAALLARAGISVTVLERATFPRYHIGESFSTSCRVIIDYLGALEKVDARGYTSKTGLLVRWGQEKDWAIDWTDQFGSDVRSWQVDRDDFDTVLLDHASESGAKVVQGAHVHRVIFEGDRATGVEWTAPGETAKQISRADFVLDASGRAGLISAQHFNNRRPHEIFRNVAIWGYWEGGELLPGSPSGGINVISSDDGWYWVIPLRDNRLSVGFVSHKSIFGERRREFGSLDEMLLKMVDESPAVREILAKGTFQPGARVEQDFSYSADSFCGPGHFLLGDAACFLDPLLSTGVHLGMYSGLLAAASVMAITDGDVSEREALAFYESLFRNAYQRLFTLVSGFYQKHAGKDRYFALAETLARQEPEHWHSSAQSFGEITAGLTDMREAADAGGRGGRPIQEIIERAATGEPTPVQQLLIAAALAESRAQGDTAPGARLTNAPGVIDANDLYDAGTGLHLVMQPRLGIGSVTSQK,O=C(O)c1ccc(C(=O)Nc2c(O)c3ccc(O)cc3oc2=O)[nH]1,O=C(O)c1ccc(C(=O)Nc2c(O)c3ccc(O)cc3oc2=O)[nH]1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-fc47b34e36f4032acd1c,1,MAIPQKATVLVIGGGPGGSYSASALAREGIDTVVLEADVFPRYHIGESLVASIRPFLKFIDLDDTFVNYGFVRKNGAAFKLNNQKEAYTDFILEAGADTFAWNVVRSESDDLMFKHAAKSGAQTFDGVRVTSIEFTDDDDDDDNNTNRPVSASWKAKDGRTGSIEFDYLVDASGRAGITSTKYLKNRTFNNYLKNVASWGYWEGATPYGMGTPVEGQPFFEALQDGSGWVWFIPLHNNTTSIGIVMNQELSTQKKKLSTTTSSRAFYLESLAGARGISRLLDPTTATLTSDIKHASDWSYNASAYGSPYLRIVGDAGAFIDPYFSSGVHLAVSGGLSAAVSIAASIRGDCPEEAAWKWHSQGVANRYGRFLLVVLGATKQIRAGDRPVLNGVGDEGFDEAFMVIRPVIQGIADVQGKVPVQDVYDAVTFSTNVVQPAAEGKRDPGWVEKARGALSHDEKEVGSVLNNLAKAYKTTDVCEGLMARLERGHLGLKLVSEV,CC1Cc2ccc(C(=O)NC(Cc3ccccc3)C(=O)O)c(O)c2C(=O)O1,CC1Cc2ccc(C(=O)NC(Cc3ccccc3)C(=O)O)c(O)c2C(=O)O1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-67c312330b0371a0a37c,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFSLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSSYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,c1ccc2c3c([nH]c2c1)CNCC3,c1ccc2c3c([nH]c2c1)CNCC3,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-709df012e236dc3f5c53,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,N[C@@H](Cc1c[nH]c2ccc(F)cc12)C(=O)O,N[C@@H](Cc1c[nH]c2ccc(F)cc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-316c0f93c7fe125865d8,1,MKIESVAIVGGGSSGWMTAAALSKLCPQLEIALIEDPNIKTVGVGESTLGHFNKFLHLLDLKDEDWMPACNATYKNSIRFTNFREGKGEVFEYPFGPSLDVSFFSQTDGINTWGKLANKYPEDFPPETFARFVNSNTYLAEHNRLTRNKDNKIPNFNFDWDTAYHIDAELFGQYLKEKIALPNGVKHIQGKVTGYQKESPNNHNFKYIILDQETAIFADLYIDCTGFKSLLLGEFMGEAFSPFSKKLANDKAMATRIPYENREEEMHNVTDCHAMKNGWVWNIPLWNRIGTGYCYSSRFVSKDDAEAEFREHLGERGKDAKIFHIDIGHGKRTRAWVNNCVGIGLSYGFIEPLESTGLLTTHENIENLVYLINQRDGYVTQAERDGFNYTCDHQIDSFSDFVAMHYAYSMRTDTPYWKWCTQMCNYMPESMGPHRQKQSTWQDLSTDTIGLNTWHINHNGISFIIAGHGLRPQSYDKLSEVLLKRNNESDYYYEDIRKDWLKHYESMVEYVKTLPTHYEFLRDEIYGSAE,O=C1CC(c2ccccc2)c2c1cnc1ccccc21,O=C1CC(c2ccccc2)c2c1cnc1ccccc21,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-8ef532f440c91b5dfa24,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLEGSGIYFIYAAIHMLARHFPNKTFDKVLVDRFNREVEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-a4c6af0cb6f02dff01ba,1,MNKTIAVIGAGLSGIAAVKQLTDGGHEVTCFEKAESFGGVFADKKIYDDLHLTISNYFMAYSDYVPNHQKLKFWSKKEYINYLGEYIQRFDIAKHIHYDHEVRRVEKQGDKWIVTCKSGGKEHSKEFDMVAVCSGHFQKPKLPDLPGLDMFDGEIEHSNDYRDKHKYTGKRVLCVGLGESSADITSEISEVARKCILSLRRYPAVAPRYMAFQEDPYFTIDTSWLTSRIVNKLPHKYHGGITKGIFNKYVNSRNDHVRIRGEWLKKSGPSHHQAVTKNERLFRPIADGKVMPNIGGIERFEKNSVVFKDGTREEVDAVVFCTGYQLSFPFLDVSISNMRDLFKQMFIPEMGHSLSFIGFVRPQQGGIPVIAEMQCRYLSKLASGEAQLPTLSEMHDVVKHDTKHWQTEYKITPHVASLVNYCHYMDSMAKLVGCMPQIPSLFKDPLLRVKLLHNPQFAAQYRLDGPNNMTHTAREFLLSFPNISSWPRIIHFEVALAAQKLLSRLRLDGLREISK,O=C(O)c1ccc(O)cc1,O=C(O)c1ccc(O)cc1,[c;D2:1]>>[c;D3:1]-[Br;D1:2] || [c;D3:1]-[C;D3:2](=[O;D1:3])-[O;D1:4]>>[c;D3:1]-[Br;D1:5]
aries-halogenase-1c8dcc518b9942ef5288,1,MTQARIRKVVIAGGGTAGWVAAAALAHQFRGLLEIVLVESEQIGTIGVGESTVPPIRAFHRFLQIDEQEFLRAVAGTFKLAISFEDWQGQGDRYIHPFGSTGQGTLVCAFHHFWLEAQRRGMHSGFDEYCLEAQAARADRFAVLQQPAVNYAYHLDAGLYARFLRTHAQRYGATRIEGKIQQVRQHADSGFVEALVLEDGQVVEGDLFIDCTGFRGLLIEQTLHTGYEDWSHWLPCDRAVAVQTESVEPPVPYTRAIAHAAGWRWQIPLQHRVGNGLVYARAHLSDDEASAMLLAAVQGTPRRDPMLVPFVTGRRLQTWNKNVVALGLASGFVEPLESTSIHLAIVAVMRLITLFPADGIAQPQVDLFNRISRAEAEHVRDFVILHYHATQREEALWRQCRAMELPESLQLRLRAWREGAHAWQDGDELFRVDSWTHVLLGQRVAPAQHHPLTRALPDQHLQQLLDGIRQPLQHVVTQLPTQQAFIDSYCKVDQSTWG,N#Cc1ccc2[nH]ccc2c1,N#Cc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-4cc3d9cba4633096fadf,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVWTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-8b7fb6aee1c63e17f44f,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,COC(=O)C1[C@H]2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O,COC(=O)C1[C@H]2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-d6723fa996ced47773f2,1,MKRARPTQPGALYSVLSLRHVACALCVVACAFLLFEYQISSLGLTALLAAFAPCLGYEEPPEPTQPLLSGNVCRVRDSLDFLDPVPRAKVTLLKRLAIAKDEISVGPTCHVNNGDEENVPLFAGQYHKTLPHDKFGQVDEDAYKKLLECVFTSDINECEKVPSGAGRRGGAKLTNPLGGTAHQVTGADSDNVFITTPDSLLSERLAAQQAEVYWMALLRDIPFGEFAKNDYVRLAAENLQSLPAFKGLNIPRSEGGKIDPVTDLFRTTWPGVTTGPVVSQFMLSDFLIDSIKVTPKADPLTPGVDYMTAFQPWLDVQNGASKLETTFDEENPRFIRNGRDLATIALRDQLYTEAFRAALILFTEGALGGEVGPYAEAERQQGFATFGEPHILTAMASASSSTRHAWYAKWQVHRMLRPEAYGALVHNTLMRDVITPLPDSILRNTELLNRVEVHNQRMNPDGEKTFLLPMAAAQGSPTHPAYPSGHAINNGAYITALKAFLGYEAGQKCFPNPVVSNDEGTKRIKYKPSGREIVGECVNEKGKLVEGLTYEGELNKISANVLLGRSHIGVHWRMDGVYGALMGETSCVRRLQQELPGLPEAREVEGKKRRGDIPPATYKFRLYSGKILELYGRNLYKLDGKLCEGAFTGDDFCDPIDEDDYSSFDDIVEEHAQFSLHGHTEL,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-02837c1944876b4fa860,1,MSAIPKKCTVLVIGGGPGGSYAASALAREGIDTVVLEGDKFPRYHIGESMLASMRHLLKFVELDGKFDSYGFVKKPGAAFKLNKNKREGYTDFLAAGGPNNYAWNVVRSEADNLMFQHAGESGAKIFDGVSVKSIQFENPTEVPDGEPNLNPGKPVSATYQIKETKEQGQIDFDYVVDASGRIGILSTKYMKNRRYNQGLKNIANWGYWEGCNKYAPGTPRENSPFFEALQDESGWAWFIPLHNGTVSVGVVMNQKLATQKKQEADLDSTEFYHDTLNKISPNLRELIGDGKFVSNVKTASDYSYSASSYSFPYARIVGDAGCFIDPYFSSGVHLALTSGLSAATTISASIRGQVDEELGSEWHTKKFSDAYTRFLLVVLSAYKQIRHQEEPVLSDFDEDNFDRAFSFFRPIIQGTADAANNKLSQEELNKTLEFCAFAFEPVENDEDRSKAMSAMQEAVDNGTGYHPDLSPEQLKAVKHIQARRAMRTSDTMNIESFGTDAINGFVPNLVRGSLGLRKQEAMSGDMGGANGHVDETNGVTVNGHHQPEGVKAH,CC(C)=CCC/C(C)=C/CC/C(C)=C/Cc1c(O)cc(C)c(C=O)c1O,CC(C)=CCC/C(C)=C/CC/C(C)=C/Cc1c(O)cc(C)c(C=O)c1O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-68c6c6e9ad314d1a5c4d,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKEPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-367461e6dd07bdb57342,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAWHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-102624ac0a714fa26aa0,1,MDVHEIDETLEKFLAENYTPERVQQLADRFQRTGFVKFDSHMRIVPEELITAVRAEADRLVREHKERRDLVLGTTGGTPRNLSVVKSQDVEQSDLIRAVTRSEVLLTFLAGITRERIIPEVSDDERYLITHQEFASDTHGWHWGDYSFAFIWALRMPPIASGGMVQAVPHTHWDKNAPRINETLCERQIDTYGLVSGDLYLLRSDTTMHRTVPLTEDGAVRTMLNVSWSAERDLGKVLTGNDRWWENPEAGAAQPVHRAG,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D2:1]-[C;D2+:2]-[C;D2:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D2:3]
aries-halogenase-c78961d3d782d8a85d93,1,MDVPLMELSGRAPVVRLHDIEADMAAATDAIRSQLTGWGFMAAEVPGIGERVEAMMNEFAAACRATGPSLSDYAYDVVPQLAVGGTHGFFPYNSEIPRLANGVPDPKEFIHVSGAMIGDQPPGAGDVLRAFPAFGTRAAEVFDIAFRLISLFGEVVRGMMPPGTPELDLSHDATNLRVIHYRDVGDREVLAHEHSGIQMLGLQLPPSDQGLQYVLHDGTWVEPVIAGTDVVLCNIGRMLTSASDGRFRPSTHRVHTKPMPAGYERLSSVLFAYPQHKARQWKMVDGELMSLNATWGDFIDSRFQGLGKQS,COP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C[C@@H]1O,COP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C[C@@H]1O,[C;D3:1]-[C;D2+:2]-[C;D3:3]>>[C;D3:1]-[C@;D3+:2](-[Cl;D1:4])-[C;D3:3]
aries-halogenase-f7b856c054de7ccced08,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIALNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-28955b1fb53203e2ff24,1,MGIPADNLQSRAKASFDTRVAAAELALARGAVPSFANGEELLYRNSETGDPSFIGSFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIAALTLGPARDPETGLPIWRSDLANSLDLEVRGWENSSAGLTFDLEGPDAQSVAMPPAPVLTSPELIAEMAELYLMALGRDIEFSEFDSPKNAAFIRSAIERLNGLEWFNTPAKLGDPPAEIRRRRGEVTVGNLFRGILPGSEVGPYLSQFIIVGSKQIGSATVGNKTLVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLDVQDAADFRGFESYEPGARLIRTIRDLATWVHFDSLYEAYLNACLILLANGVPFDPNLPFQQEDKLDNQDVFVNFGSAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKNAFLKSESVFPEVDVLVEELSSILDDSASSNEKQNIADGDVSPGKSFLLPMAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDANFQIDQVFEVDTDEDKLVKSSFPGPLTVAGELNKLADNVAIGRNMAGVHYFSDQFESLLLGEQIAIGILEEQSLTYGENFFFNLPKFDGTTIQI,CC(C)=CCC/C(C)=C\CO,CC(C)=CCC/C(C)=C\CO,[C;D1+:1]=[C;D1+:2].[O;D0+:3]>>[C;D2+:1](-[Br;D1:4])-[C;D2+:2]-[O;D1+:3]
aries-halogenase-82607c98dec8f45ac84e,1,MNKPIKNIVIVGGGTAGWMAASYLVRALQQQANITLIESAAIPRIGVGEATIPSLQKVFFDFLGIPEREWMPQVNGAFKAAIKFVNWRKSPDPSRDDHFYHLFGNVPNCDGVPLTHYWLRKREQGFQQPMEYACYPQPGALDGKLAPCLSDGTRQMSHAWHFDAHLVADFLKRWAVERGVNRVVDEVVDVRLNNRGYISNLLTKEGRTLEADLFIDCSGMRGLLINQALKEPFIDMSDYLLCDSAVASAVPNDDARDGVEPYTSSIAMNSGWTWKIPMLGRFGSGYVFSSHFTSRDQATADFLKLWGLSDNQPLNQIKFRVGRNKRAWVNNCVSIGLSSCFLEPLESTGIYFIYAALYQLVKHFPDTSFDPRLSDAFNAEIVHMFDDCRDFVQAHYFTTSRDDTPFWLANRHDLRLSDAIKEKVQRYKAGLPLTTTSFDDSTYYETFDYEFKNFWLNGNYYCIFAGLGMLPDRSLPLLQHRPESIEKAEAMFASIRREAERLRTSLPTNYDYLRSLRDGDAGLSRGQRGPKLAAQESL,Cc1c[nH]c2ccccc12,Cc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-23c5910b8b10cfa86e40,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,CC(=O)NCCc1c[nH]c2ccccc12,CC(=O)NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-bc57590a33fe355e1743,1,MIPAPLRNIVIVGGGTAGWMAAAAFARVLGPSFNVQLIESEQLGTIGVGEATVPHIKAFNNLLGIDEAEFVRQTQGSFKLGIEFVDWQRPGTSYIHGFGTQIGHPLGLLPFHQYWIKQQRRGKAQPLGAYTLNTVAATRGKFMTSAGDVPANSPLASIAYAYHFDASQYARFLRGYAEQRGVTRLEGLIEQVQLDAHTGSVQSVQLASGQVVSGDLFIDCSGFRGLLIEEALHTGYHDFTHWLPCDRALAVPCEKVGPPTPYTRSTARAAGWQWRIPLQHRTGNGYVYSSAHISDDEAAAALLANLDGTPLADPRPLRFTTGRRKQFWNRNVVALGLASGFLEPLESTSIHLIQSGISKLLELFPREGISPVLVQRYNDRLAFEFDRIRDFLVLHYHATERDDSAFWRHCRTMPITPELQTTLDLFRDSGRFYRNAEEMFAEISWVQVMVGQGILPQGYHPLVDQVPDTDAEGFLASVAQTISHCVDVMPTHQQFIDRYCRADPVR,NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O,NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-f391e014b2ee3a429552,1,MTQARIRKVVIAGGGTAGWVAAAALAHQFRGLLEIVLVESEQIGTIGVGESTVPPIRAFHRFLQIDEQEFLRAVAGTFKLAISFEDWQGQGDRYIHPFGSTGQGTLVCAFHHFWLEAQRRGMHSGFDEYCLEAQAARADRFAVLQQPAVNYAYHLDAGLYARFLRTHAQRYGATRIEGKIQQVRQHADSGFVEALVLEDGQVVEGDLFIDCTGFRGLLIEQTLHTGYEDWSHWLPCDRAVAVQTESVEPPVPYTRAIAHAAGWRWQIPLQHRVGNGLVYARAHLSDDEASAMLLAAVQGTPRRDPMLVPFVTGRRLQTWNKNVVALGLASGFVEPLESTSIHLAIVAVMRLITLFPADGIAQPQVDLFNRISRAEAEHVRDFVILHYHATQREEALWRQCRAMELPESLQLRLRAWREGAHAWQDGDELFRVDSWTHVLLGQRVAPAQHHPLTRALPDQHLQQLLDGIRQPLQHVVTQLPTQQAFIDSYCKVDQSTWG,OCCc1c[nH]c2ccccc12,OCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-209eb5f20ab018ff6f1e,1,MSSNVVGFSGDFDVIVIGGGPAGATTAALLSKRGRRVLVLDRERFPRYHVGESLIPGVMVPMEELGLKERMEAKGFERKYGGTLVWGNNEVPWNFSFSTGGRIPYAFHTRRADLDALVLDRARELGAFVVEDATVKDTIEEDGRVVGVRYALRGLGGTQEARASLVIDASGQARVIGRKYTEVNWNEQLRNVAVWTYFDNCHRLPGDEWSNILIEGTSDGWFWGIPIDKGVFSVGYVTRSELATESGKSLEDLFQSEIASTTKLKELLKDATQAAGYRSARDWSYTNDRFYGKGWALVGDAAAFVDPLFSTGVALATLAGSTLSKVVDQILQYPAIEEKALDRYSNAYQEFFHDIRKFVEGFYDRSKTKGFYFNMAQEMVDPEKENAAEVDFVKLVSGLSGRQGGLFELNVDDLIEDAKSTPADS,CC(C)=CCC1=C(O)C(=O)c2cc(O)c(C)c(O)c2C1=O,CC(C)=CCC1=C(O)C(=O)c2cc(O)c(C)c(O)c2C1=O,[C;D2+:1](-[O;D1:2])=[C;D3+:3](-[C;D2:4])-[C;D3:5]>>[C;D2+:1](-[O;D1:2])-[C@;D4+:3](-[Cl;D1:6])(-[C;D2:4])-[C;D3:5]
aries-halogenase-cef5838d118dccd9de48,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMVINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,COC(=O)[C@@H]1[C@H]2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O,COC(=O)[C@@H]1[C@H]2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-db9351a297a7362b3c91,1,MNKPIKNIVIVGGGTAGWMAASYLVRALQQQANITLIESAAIPRIGVGEATIPSLQKVFFDFLGIPEREWMPQVNGAFKAAIKFVNWRKSPDPSRDDHFYHLFGNVPNCDGVPLTHYWLRKREQGFQQPMEYACYPQPGALDGKLAPCLSDGTRQMSHAWHFDAHLVADFLKRWAVERGVNRVVDEVVDVRLNNRGYISNLLTKEGRTLEADLFIDCSGMRGLLINQALKEPFIDMSDYLLCDSAVASAVPNDDARDGVEPYTSSIAMNSGWTWKIPMLGRFGSGYVFSSHFTSRDQATADFLKLWGLSDNQPLNQIKFRVGRNKRAWVNNCVSIGLSSCFLEPLESTGIYFIYAALYQLVKHFPDTSFDPRLSDAFNAEIVHMFDDCRDFVQAHYFTTSRDDTPFWLANRHDLRLSDAIKEKVQRYKAGLPLTTTSFDDSTYYETFDYEFKNFWLNGNYYCIFAGLGMLPDRSLPLLQHRPESIEKAEAMFASIRREAERLRTSLPTNYDYLRSLRDGDAGLSRGQRGPKLAAQESL,Nc1ccccc1C(=O)C[C@H](N)C(=O)O,Nc1ccccc1C(=O)C[C@H](N)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-4f97f2eebf92cde58c10,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSSYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-3055e0d8130c7a197bc6,1,MAPTPKYTFTERAAAGNLSDAEILNSNNPTGSELPDESDVVVGGAGIHGLIYALHASKYKPNNLKISVIEKNTRPGYKIGESTLPIFYTWCKLHGISAAYLLRLFGLKDGLCFYFLDRENQGQYTDFCSVGAPGLVLASLQIERPMSELLFTILAQRNGVNVYHGREVDFKSTVVQGGGQGNKIAVSRGKYDSTPKTIDSALFVDATGRFRQFCSKKAPRHRFDGWNCNAFWGYFTAPKDESKIPFDLYEGDHTNHLCFPEGWVWVIRLPSWEGSLIANLMDMVTYILECADAGVPGDELPSSEELARMFGLKFQWVTSIGFAVRNDVKYPEDLSAYGTREAEQKFNYFVQKYELLQQFMSNFELIENLYGPGTTWFIRKTLAYQSPVVSGPGWLAIGDACGFTNPLYSPGINVGMSTSTWAAQLSHRIVEIGKSAPADAAESSIRKLLVPYDDYCKSLVPALEQMNRFNYVCYRDTRLGPQVACLWQFFAGIERYLSDVNIETFAHYAIKWVWGAMVPEYQQVAQKCIEHIETVPLDERLPDAMVDELLAFSNRIKSAAVAADDFSLRWDAILRSFDRSLNFVEGKTSRDIYTRQCSGCGAWLQLRPDWKKCHSCGLLGTEPQTAVTFDPPLTAEEEALLYAAWNTAPKYDPSKELKLPTPTRPAA,CC1(C)c2[nH]c3ccccc3c2C[C@@]23CN4CCC[C@]4(CC12)C(=O)N3,CC1(C)c2[nH]c3ccccc3c2C[C@@]23CN4CCC[C@]4(CC12)C(=O)N3,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-85e36899399df701301f,1,MPFVTASDGTEIFYKDWGSGRPIMFHHGWPLSSDDWDSQLLFLVQRGYRVIAHDRRGHGRSAQVGHGHDMDHYAADAAAVVAHLGLRDVVHVGHSTGGGEVARYVARHGAGRVAKAVLIGAVPPLMVQTESNPEGLPVEVFDGFREAVVTNRSQFYLDLASGPFYGFNRPGADISQGVIQNWWRQGMTGSAQAHYEGIKAFSETDFTDDLRAIDVPTLIMHGDDDQIVPIANSAETAVTLVKNARLKVYPGLSHGMCTVNADTVNADLLSFIES,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-e0e3fcdfb0803ca53891,1,MVKIKHIFYNLNNVLLFFFLCLLTCRAQSAIVVFQSDFGTKDGAVSEVKGVMYTVDPSLIISDLTHEIPAYNIWEASYRLYQTAPYWPKDTVFISVVDPGVGTKRRSIVVLTNNGQYFVTPDNGTLTLIDNRFGIKEVREIDETKNRLDGSGSSNTFFGRDVYGYTAAKLASGKISFEEVGPKLYEPIVKIPYQKATIENDKLQGTIVILDPQYGNLWTNIDKQLLEQYGFEPGACYKVRIYHKNHNTFVGLLLYQKTFGDISKGKDLLYLNSLLHLAIATNQGSFAKIHKIGSGPDWTITVEKSKKSKKQCDSEWIYIQ,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,[C;D1+:1]-[C;D2+:2]-[S;+;D3:3]>>[C;D1+:1]-[C;D2+:2]-[Cl;D1:4]
aries-halogenase-21eb478c997305f06e5e,1,MINSVLIVGGGTAGWMTAAYLSKAFDKNINITVVESKEVKKIGVGEATFSTVRHYFDYLGLNESEWLPECSGSYKLGIRFENWDGQGNHFYHPFERWEVVKGFPISEWWLSKKLKDQRFDYDTFLTPHLCEAKRSPRRLDGSLFAQSIDKSLGQSTLAEQRAQYPYAYHFDADGVASFLKRYAMNRGVKHIEDDVTHVEIDTNGNIGYLEAKIYGKLRADLYIDCTGFKGLLINKALNEPFISFSDVLKNNRAVALRVPRENENDIEPYTTARTMSNGWRWTIPLYKRNGYGYVYCNKYQSPEEAEMELRKSIPYENAECVANHIRMRIGRSNRSWVKNCVAIGLSSAFVEPLESTGIFFIQHGIEQLVRFFPRSSGNELLIEEYNTRVNRVVDGVKEFLLLHFSLAQRNDTLYWKEWKNVELPKELLKKITLAQDHLLDKETIYPFYHGFEEYSWNTMILGLCSGSLNNKPALSLMTSDEADEMLLQHYMKAENMVNNLPTCYEYLKHIHDLKNKN,N#CCc1c[nH]c2ccccc12,N#CCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-8a8b2d66735ed03d0841,1,MDVHEIDETLEKFLAENYTPERVQQLADRFQRTGFVKFDSHMRIVPEELITAVRAEADRLVREHKERRDLVLGTTGGTPRNLSVVKSQDVEQSDLIRAVTRSEVLLTFLAGITRERIIPEVSDDERYLITHQEFASDTHGWHWGDYSFAFNWALRMPPIASGGMVQAVPHTHWDKNAPRINETLCERQIDTYGLVSGDLYLLRSDTTMHRTVPLTEDGAVRTMLNVSWSAERDLGKVLTGNDRWWENPEAGAAQPVHRAG,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D2:1]-[C;D2+:2]-[C;D2:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D2:3]
aries-halogenase-6953c2a883537cc80135,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,Nc1ccc(-c2nccs2)cc1,Nc1ccc(-c2nccs2)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-ce7d916f3b5c6edb4212,1,MAIPQSCTVLVAGGGPGGSYTAAALAREGVDVVLLEADCHPRYHIGESLLPSMRYLLRFIDLEDTFEQHGFQKKLGAFFKLNAKSAGYTDFIRANGPNGYSWNVVRSESDEILFRHATKSGAKTFENVSLKSVNFEPYENDKFTSQDKLTNPGRPVSAEWKTKDGCSGTISFDYLVDATGRVGILSTKYLKNRKFNESFRNIAMWGYFKGNIPPSPGTDRENQPISEGMRDGSGWVWMLPLHNGTVSIGAVVRKDIFQAKKKALPEGTTEAQTLASLVALCPTISSYLEPAELASGIRQAADYSYSANAYAGPNFRIVGDAGCFIDPFFSSGHHLALSSALAAATSINACIRGDCNEFDASRWFAKKVDEGYTLFLVVVMAALKQIRMQEQPILSDLDEEGFDRAFTILRPVIQGAADKETAPKAKGESITETIDLCLTALNDLHDTELQRKLTSIVEAKGTPEQEQLLGKLSPDETAALHRMRAMHSILPMGELEDFENSNIDGFKARLEKGSLGLRRERALCRDHAGDLQM,CC(=O)NC1CNc2ccccc2C1,CC(=O)NC1CNc2ccccc2C1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-0aa598c735f77296910c,1,MNTRNPDKVVIVGGGTAGWMTASYLKKAFGERVSVTLVESGTIGTVGVGEATFSDIRHFFEFLDLREEEWMPACNATYKLAVRFQDWQRPGHHFYHPFEQMRSVDGFPLTDWWLQNGPTDRFDRDCFVMASLCDAGRSPRYLNGSLLQQEFDERAEEPAGLTMSEHQGKTQFPYAYHFEAALLAEFLSGYSKDRGVKHVVDEVLEVKLDDRGWISHVVTKEHGDIGGDLFVDCTGFRGVLLNQALGVPFVSYQDTLPNDSAVALQVPLDMEARGIPPYTRATAKEAGWIWTIPLIGRIGTGYVYAKDYCSPEEAERTLREFVGPEAADVEANHIRMRIGRSEQSWKNNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKHFPAGDWHPQLRAGYNSAVANVMDGVREFLVLHYLGAARNDTRYWKDTKTRAVPDALAERIERWKVQLPDSENVFPYYHGLPPYSYMAILLGTGAIGLRPSPALALADPAAAEKEFTAIRDRARFLVDTLPSQYEYFAAMGQRV,O=C(O)CCc1c[nH]c2ccccc12,O=C(O)CCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-55c8079ac96c6a4f6a94,1,MIRSVVIVGGGTAGWMTASYLKAAFDDRIDVTLVESGNVRRIGVGEATFSTVRHFFDYLGLDEREWLPRCAGGYKLGIRFENWSEPGEYFYHPFERLRVVDGFNMAEWWLAVGDRRTSFSEACYLTHRLCEAKRAPRMLDGSLFASQVDESLGRSTLAEQRAQFPYAYHFDADEVARYLSEYAIARGVRHVVDDVQHVGQDERGWISGVHTKQHGEISGDLFVDCTGFRGLLINQTLGGRFQSFSDVLPNNRAVALRVPRENDEDMRPYTTATAMSAGWMWTIPLFKRDGNGYVYSDEFISPEEAERELRSTVAPGRDDLEANHIQMRIGRNERTWINNCVAVGLSAAFVEPLESTGIFFIQHAIEQLVKHFPGERWDPVLISAYNERMAHMVDGVKEFLVLHYKGAQREDTPYWKAAKTRAMPDGLARKLELSASHLLDEQTIYPYYHGFETYSWITMNLGLGIVPERPRPALLHMDPAPALAEFERLRREGDELIAALPSCYEYLASIQ,Nc1ccccc1C(=O)C[C@H](N)C(=O)O,Nc1ccccc1C(=O)C[C@H](N)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-864995ea35b82212a9a2,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNPWSNGSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-8c9a013ab70c0434313e,1,MSIPKSCEVLVAGGGPAGSYAASALAREGVDVVLLEADKHPRYHIGESMLPSIRPLLRFIDLEETFEKHGFQKKLGAAFKLTAKREGYTDFVAAHGPNGYSWNVVRSESDELLFKHAAKSGALTFQGVKVDSLEFEPYDSDFPSGGKVANPGRPVAARWSAKDGRSGTISFQYLVDATGRAGITSTKYLKNRKFNEGLKNLAIWGYYKGARPWAEGTPRENQPYFEGMRDGAGWCWTIPLHNGTVSVGAVLRSDLFFAKKKSLGEDVTNAMIMAECMKLCPTIKELLEPAELVSDIKQATDYSYSASAYAGPYFRIVGDAGCFIDPFFSSGHHLAMAGALAAAVSIRASMKGDCSEYEASNWHARKVDEGYTLFLLVVMAALKQIRMQEEPVLSDIDDDGFDRAFQFLKPVIQGSGSAEIVKRFTKKEVSEAIDFAVLALDNMAGAGEHANETNGSNGTGETNGDAKTLENITVEDEKVLSGIRILAKVAPSADMKDLEGTAIDGFMPRLEHGHLGLNRV,Oc1ccc2cnccc2c1,Oc1ccc2cnccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-3dd9c0995d54c0abd51a,1,MIRSVVIVGGGTAGWMTASYLKAAFDDRIDVTLVESGNVRRIGVGEATFSTVRHFFDYLGLDEREWLPRCAGGYKLGIRFENWSEPGEYFYHPFERLRVVDGFNMAEWWLAVGDRRTSFSEACYLTHRLCEAKRAPRMLDGSLFASQVDESLGRSTLAEQRAQFPYAYHFDADEVARYLSEYAIARGVRHVVDDVQHVGQDERGWISGVHTKQHGEISGDLFVDCTGFRGLLINQTLGGRFQSFSDVLPNNRAVALRVPRENDEDMRPYTTATAMSAGWMWTIPLFKRDGNGYVYSDEFISPEEAERELRSTVAPGRDDLEANHIQMRIGRNERTWINNCVAVGLSAAFVEPLESTGIFFIQHAIEQLVKHFPGERWDPVLISAYNERMAHMVDGVKEFLVLHYKGAQREDTPYWKAAKTRAMPDGLARKLELSASHLLDEQTIYPYYHGFETYSWITMNLGLGIVPERPRPALLHMDPAPALAEFERLRREGDELIAALPSCYEYLASIQ,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-2ec42bc1f3e672fc1cf7,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMMGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLEGSGIYFIYAAIHMLARHFPDKTFDKVLVDRFNREVEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFTGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-6719009a76851c4bed2f,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYRGNFEEEFRNPWTNGSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-40794500a2845c943a0f,1,MKHETIVLADGFRVGVSTVGTGAPLVFLHGLSVSAKAYEEMLTRLAEHGFRVIALDAANHGRSGSLPTGHTVEDMTRVTLKTLDELDIHRAIFAGHSMGGGMVVEIAARHPHRVAAAVLLDAAAGQEHHDNIKVGHYATLAFRAAKKLGEAVTDIVGDGYEAMHLRDTGEKLSFLGMLRDSVSGLRFVRAAFALMKADTTPLLHAMYRHGVPTAVLHGLHDQIVPYEAGLSTAKITNASFYGVDGFHSWMLADPELAADLIALALLDLFPRRYITGAG,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-ffa6059b954a4602a9fa,1,MSDNRIRKILVLGGGTTGWMSAAYLAKALGSSAEVTVLEAPSVPRIGVGEATIPNLQKVFFDFLGLSEEEWMPECNASFKLGIRYINWRTPGSGEALGREHQGGKDHFDHVFGVLPSHENLPLSHYWTHKKLTGQTDEPFDQACYTQPQIFDRNLSPRYLDGTRWASYAWHFDAQKVADFLGRFSVEKLGVQHIQDKFVGADVDQRGHIVAVKTEEGRRLEADLFIDCSGFRSLLMNGVMKEPFLDMSDHLLNDRAVATQIPHDDENNGVEPFTSAIAMSAGWTWKIPMLGRFGTGYVYSSRFTSQDEATQEFCRMWGIDPETHPLNHVKFRVGRNRRAWVKNCIGLGLANQFVEPLESTGIYFVYAALYQLVKHFPDKSFDPVLVNRFNHEVEEMFDDTRDFIQGHFSFAPRNDTPYWRACKELELAPRFVEKVKEYKSGLGVNLPVTDEAGYYGNFEAEFRNFWSNANYYCILAGLGELPDNPMPLLAHQPESIASAEAVFEEIKKRREELLATLPSTHEYLLKLHGKA,CC[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1,CC[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-0fe39b99b379952df916,1,MTEVTMGEPIRNIVILGGGTAGWMAASYLGKALSGQAAISVVEAPAIPRIGVGEATVPNLQRVFFDYLGLPEEEWMSKCNAGFKMAVKFINWRTPGPGEPVSRQDADGSDHFYHPFGLLPSPDGVPLSHYWTRKQLSGATSEPFDYASFVEPPLMDAKRSPRFLDGTRCTNYAWHFDAALVAAFLRDFATVKQGVRHIEGTVSDVRADSRGYIESVTLESGEVIGGDLFVDCSGLRGLLINKTLGEPFIDMSDHLLNNSAVATQVPHDDEANGIEPYTSSIAMPAGWTWKIPMPGRFGTGYVYCDKFADKDEAARDLCGLWGLDPEKVPLNHIKFRVGRNRRAWVGNCVSIGLSSCFVEPLESTGIYFITASLHQLVKHFPERDVDPVLRDRFNREIVDMFDDTRDFLQAHFSLSPRTDTPFWRATKELTLADQIKEKIEMYRSGVPVNPPVTDEGTYYGNFEAEFRNFWTNGSYYSVFAGLGVRPRSSLPILSYRPDSVAAAERAFADVKARQRQLLSELPSAYEYLSSLHQADQPRHAPAETPRRRQV,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-8cf04f0d07191f042b1d,1,MSNNTISTKPALHFLDINATEVKKYPTAIQDIIINRSFDGMIIRGVFPRDTMEQVARCLEEGNDGGMKSILNKNEEFGTKVAQIYGHAIVGQSPDLKDYFASSAIFRQACRTMFQGSPDFEEQVESIFHSLSGLPVEIPTGPEGQTYTPATIRLLLEGREIAVHVGNDFLLMPAANHLKTLLDLSDQLSYFIPLTVPEAGGELVVYNLEWNPQEVDKSADLHKYIDEVESKFKSNQSQSVAYAPGPGDMLLFNGGRYYHRVSEVIGNSPRRTIGGFLAFSKERNKIYYWS,*[C@@H]1[C@@H]2c3c([nH]c4ccccc34)C(C)(C)[C@H]2CC[C@@]1(C)C=C,*[C@@H]1[C@@H]2c3c([nH]c4ccccc34)C(C)(C)[C@H]2CC[C@@]1(C)C=C,[C;D2:1]-[C;D2+:2]-[C;D4:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D4:3]
aries-halogenase-b7768fbb1847758d75c3,1,MDVPLMELSGRAPVVRLHDIEADMAAATDAIRSQLTGWGFMAAEVPGIGERVEAMMNEFAAACRATGPSLSDYAYDVVPQLAVGGTHGFFPYNSEIPRLANGVPDPKEFIHVSGAMIGDQPPGAGDVLRAFPAFGTRAAEVFDIAFRLISLFGEVVRGMMPPGTPELDLSHDATNLRVIHYRDVGDREVLAHEHSGIQMLGLQLPPSDQGLQYVLHDGTWVEPVIAGTDVVLCNIGRMLTSASDGRFRPSTHRVHTKPMPAGYERLSSVLFAYPQHKARQWKMVDGELMSLNATWGDFIDSRFQGLGKQS,Nc1ncnc2c1ncn2[C@H]1CC[C@@H](COP(=O)(O)O)O1,Nc1ncnc2c1ncn2[C@H]1CC[C@@H](COP(=O)(O)O)O1,[C;D2:1]-[C;D2+:2]-[C;D3:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D3:3]
aries-halogenase-f0d588a225e6e6ba0501,1,MHAPAPSESQRLVRRVVIAGGGTAGWMAAAALSKLLGRQLQITLVESDEIGTVGVGEATIPSLVTFHRLLEIDEAQFMAATQATFKVGIAFEHWRDVDRHYIHSFGHTGTDHWSAGFQHFWLKAHARGVARDFGDYCLELRAAQEGRFAHLPNGGMNYAYHLDAGLYARFLRRFSEGFGVQRIEGRIGSVQTDAHSGDIAALVLDDGTRIEGDLFLDCTGFRALLIGQTLGVGSEDWSRWLFADSALAVQTESVGAPVTFTRARADRAGWMWRIPLQHRVGNGIVYSSRYTDQDSAAQVLEHNLQGRALTTPRALRFTPNQRHRVWEKNCVALGLASGFLEPIESTNIHLIQRGIVRLLQTFPQVIDPVDIAEYNRQAAEEIAHIRDFVILHYHATDRRDTAFWRDCASMEIPDSLRHRMELFRQSGRVFHQGNELFAENSWIQVMLGQGIVPRHHHPVADLMGDAELSQFLEGIRQRVEATLARLPPHAEFLRRYCPAPAPPAPMPQPAPGTPLAAPAA,NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O,NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-5817ae4948371f9b6b7d,1,MTASYLKAAFGDRIDITLVESGHIGAVGVGEATFSDIRHFFEFLGLKEKDWMPACNATYKLAVRFENWREKGHYFYHPFEQMRSVNGFPLTDWWLKQGPTDRFDKDCFVMASVIDAGLSPRHQDGTLIDQPFDEGADEMQGLTMSEHQGKTQFPYAYQFEAALLAKYLTKYSVERGVKHIVDDVREVSLDDRGWITGVRTGEHGDLTGDLFIDCTGFRGLLLNQALEEPFISYQDTLPNDSAVALQVPMDMERRGILPCTTATAQDAGWIWTIPLTGRVGTGYVYAKDYLSPEEAERTLREFVGPAAADVEANHIRMRIGRSRNSWVKNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKNFPAADWNSMHRDLYNSAVSHVMDGVREFLVLHYVAAKRNDTQYWRDTKTRKIPDSLAERIEKWKVQLPDSETVYPYYHGLPPYSYMCILLGMGGIELKPSPALALADGGAAQREFEQIRNKTQRLTEVLPKAYDYFTQLR,Nc1ccccc1C(=O)O,Nc1ccccc1C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-af6b495dd2d7c1174d63,1,MSNNTVSTKPALHFLDINATEVKKYPTAIQDIIINRSFDGMIIRGVFPRDTMEQVARCLEEGNDGGMKSILNKNEEFGTKVAQIYGHAIVGQSPDLKDYFASSAIFRQACRTMFQGSPDFEEQVESIFHSLSELPVEIPTGPEGQTYTPATIRLLLEGREIAVHVGNDFLLMPAANHLKTLLDLSDQLSYFIPLTVPEAGGELVVYSLEWNPQEASKYAQMQEYMDDVESKIKSNQSQSVAYAPGPGDMLLFNGGRYYHRVSEVIGNSPRRTIGGFLAFSKQRDKIYYWS,C=C[C@]1(C)CC[C@H](C(=C)C)[C@@H](c2c[nH]c3ccccc23)[C@H]1C#N,C=C[C@]1(C)CC[C@H](C(=C)C)[C@@H](c2c[nH]c3ccccc23)[C@H]1C#N,[C;D2:1]-[C;D2+:2]-[C;D4:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D4:3]
aries-halogenase-0b36980af5c0346a818b,1,MKKTISALFLSACIGLSSVYADNALILQTDFSLKDGAVSAMKGVAFSVDSNLKIFDLTHEIPPYNIWEGAYRLYQTASYWPKGSVFVSVVDPGVGTNRKSVVLKTKNGQYFVSPDNGTLTLVAQTLGIDSVREIDEKANRLKGSEKSYTFHGRDVYAYTGARLASGAITFEQVGPELPPKVVEIPYQKAKATKGEVKGNIPILDIQYGNVWSNISDKLLNQAKIKLNDTLCVTIFKDSKKQYEGKMPYVASFGGVLKGQPLVYLNSLLNVSVALNRDNFAQKHQIKSGADWNIDIKKCDK,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,[C;D1+:1]-[C;D2+:2]-[S;+;D3:3]>>[C;D1+:1]-[C;D2+:2]-[Cl;D1:4]
aries-halogenase-3aa82834b765ea042146,1,MCAPLEKDDIRRLSQAFHRFGIVTVTELIEPHTRKLVRAEADRLLDQYAERRDLRLATTDYTRRSMSVVPSETIAANSELVTGLYAHRELLAPLEAIAGERLHPCPKADEEFLITRQEQRGDTHGWHWGDFSFALIWVLQAPPIDVGGLLQCVPHTTWDKASPQINRYLVENPIDTYHFESGDVYFLRTDTTLHRTIPLREDTTRIILNMTWAGERDLSRKLAADDRWWDNAEVSAARAIKD,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-66c2e6dd7fe34b78c205,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,C[C@@H]1C/C=C/CC/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,C[C@@H]1C/C=C/CC/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-58eb0dd988df36c54ae8,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIILNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-f343a80aafa11416dbea,1,MADAMPKVIVIGGGPGGSTAAGLLAKGGVEVKLLERAEFPRYHIGESITTSCRAIIDYVGALEKVNACGFTTKTGVLMRWGQEKDWVIDWTAQFGADTRSWQVDREIFDQVLLDNAADSGAEVVQQAHVKRVLFDGDRAVGVEWQPAGGELRTETADYVIDASGRAGLISAQHYNNRRPHEIFRNVAIWGYWENAELLPDSPAGGINVISSPDGWYWLIPLRDNRFSVGFVTHKTNFVERRREFDSQEAMLAAVLGESETMKQVLAQATQLPGVRIEQDFSYAADKFCGDGYFLVGDSACFLDPLLSTGVHLAMYSGMLSAASILSLQRGEVNEPEAQAFFESLYRNAYHRLFTLVISFYQQHAGKDRYFALADTLSRAAQGDTQSADLAFGEIIAGLTDLREAADRAGTAAAPITETIDAAATGGAKPVQELLGAAEQARLRAEESSPNQRVTMAPMYIDANDLYDAASGLYLVTEPRLGISRVTSEAAVAAG,CCc1cc(O)c(Br)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C,CCc1cc(O)c(Br)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-3b47492744946d5a188b,1,MKIESVAIVGGGSSGWMTAAALSKLCPQLEIALIEDPNIKTVGVGESTLGHFNKFLHLLDLKDEDWMPACNATYKNSIRFTNFREGKGEVFEYPFGPSLDVSFFSQTDGINTWGKLANKYPEDFPPETFARFVNSNTYLAEHNRLTRNKDNKIPNFNFDWDTAYHIDAELFGQYLKEKIALPNGVKHIQGKVTGYQKESPNNHNFKYIILDQETAIFADLYIDCTGFKSLLLGEFMGEAFSPFSKKLANDKAMATRIPYENREEEMHNVTDCHAMKNGWVWNIPLWNRIGTGYCYSSRFVSKDDAEAEFREHLGERGKDAKIFHIDIGHGKRTRAWVNNCVGIGLSYGFIEPLESTGLLTTHENIENLVYLINQRDGYVTQAERDGFNYTCDHQIDSFSDFVAMHYAYSMRTDTPYWKWCTQMCNYMPESMGPHRQKQSTWQDLSTDTIGLNTWHINHNGISFIIAGHGLRPQSYDKLSEVLLKRNNESDYYYEDIRKDWLKHYESMVEYVKTLPTHYEFLRDEIYGSAE,Cc1nc2ccc(N)cc2nc1C,Cc1nc2ccc(N)cc2nc1C,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-46437ab18a6657040b45,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Nc1ccccc1C(=O)O,Nc1ccccc1C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-e66f404f78b6875bb24f,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATHPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNCWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-ee932b02fc14995ab108,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNCWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-52a6eb687cd22e80d334,1,QTCSTSDDADDPTPPNERDDEAFASRVAAAKRELEGTGTVCQINNGETDLAAKFHKSLPHDDLGQVDADAFAALEDCILNGDLSICEDVPVGNSEGDPVGRLVNPTAAFAIDISGPAFSATTIPPVPTLPSPELAAQLAEVYWMALARDVPFMQYGTDDITVTAAANLAGMEGFPNLDAVSIGSDGTVDPLSQLFRATFVGVETGPFISQLLVNSFTIDSITVEPKQETFAPDVNYMVDFDEWLNIQNGGPPAGPELLDDELRFVRNARDLARVTFTDNINTEAYRGALILLGLDAFNRAGVNGPFIDIDRQAGFVNFGISHYFRLIGAAELAQRSSWYQKWQVHRFARPEALGGTLHLTIKGELNADFDLSLLENAELLKRVAAINAAQNPNNEVTYLLPQAIQEGSPTHPSYPSGHATQNGAFATVLKALIGLDRGGDCYPDPVYPDDDGLKLIDFRGSCLTFEGEINKLAVNVAFGRQMLGIHYRFDGIQGLLLGETITVRTLHQELMTFAEESTFEFRLFTGEVIKLFQDGTFTIDGFKCPGLVYTGVENCVS,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-a7ef9d0560e214494904,1,MNTRRQQAQNIRNNAAELAANRPHPQHINNKEEYEYRRPKKDGNEPSHIANFTKGLPHDEHTGLLLNSADYDQFVLGIQSGDTTDFARTPLGPAELPKVHGCLSKQKIDCDDDHRSGFWKSQIAQGAAGGDGAKLRAWESAGAGLVFDLEGPDAQAVTMPPAPRLESPELTSEIAEVYSQALLRDIHFSQLRDPGLGDQVNACDSCPTQLSIYEAIDILNTVQIEGQNWFSANCCDLTDDEQARQRPLVTRQNIFRGIAPGDDVGPYLSQFLLIGNNALGGGVFGQEAGHIGYGAIRIDQRVRKATPCKDFMTNFETWLDVQNGADLRGLETYVDADPGKCREFPAYRVITTPRDLATYVHYDALYEAYLNACLILLGMGAPFDPGIPFQKPDVEDKQQGFAHFGGPQILTLVCEAATRGLKAVRFQKFNVHRRLRPEALGGLVDRYKHGKGAGDELKPVAALVEALENVGLLSKVVAHNQLQNQNLDRSGDPSSAGDNYFLPMAFPEGSPMHPSYGAGHATVAGACVTMLKAFFDHGWQLNLGMANGKYISYEPNQDGSSLQQVLLDCPLTVEGELNKIAANISIGRDWAGVHYFTDYIESLRLGEKIAIGILEEQKLTYGENFTMTVPLYDGGSIQI,CC1(C)CC(=O)C(Cl)C(=O)C1,CC1(C)CC(=O)C(Cl)C(=O)C1,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-da2c575e48ee7651b9e9,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVHTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-d8ed8ca27d83a63df698,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLEGSGIYFIYAAIHMLARHFPDKTFDKVLVDRFNREVEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFTGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-6fa0b9010de4170dbe21,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,N[C@@H](Cc1c[nH]c2cc(F)ccc12)C(=O)O,N[C@@H](Cc1c[nH]c2cc(F)ccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-587a490557627756d252,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPGFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-b3b32ef85491ba019823,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWCPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-929335bd815765d7b676,1,MEVEKVLQPISKPGESGYDHFMPEDFIRPEDEQPELTTFKGPTPDIPVIDLSEPNEEKLVRALVSASEEWGIFQVVNHGIPTDVIDKFMRVGREFFELPQEEKMAYARPPGATSLEGYETRFERDYVGKKAWADLLFHNVWPPSIVNYSFWPKNPPSYREATEEYAKHIPIVADKLFKILSLGLGLEGNTIKEGLGGEKMEFLMKINYYPPCPRPDLALGVVPHTGYPAMTILIPTDVPGLQVFKDDLWYDAKYIPYALVVNIADQIEILSNGKYKSVLHRAKVNKEKVRMSWPIFCTPPADMVIGPIPELINEENPARYKYIEYKDYVQLKLKNKSAAFEGPNVAKVTSK,COC1=CC(=O)[C@]2(CC[C@@]34C(OC)=C(OC)C(=O)C[C@]32CCN4C)[C@@H]1O,COC1=CC(=O)[C@]2(CC[C@@]34C(OC)=C(OC)C(=O)C[C@]32CCN4C)[C@@H]1O,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-a5a3f1ccc4741c424479,1,MNKPIKNIVIVGGGTAGWMAASYLVRALQQQANITLIESAAIPRIGVGEATIPSLQKVFFDFLGIPEREWMPQVNGAFKAAIKFVNWRKSPDPSRDDHFYHLAGNVPNCDGVPLTHYWLRKREQGFQQPMEYACYPQPGALDGKLAPCLSDGTRQMSHAWHFDAHLVADFLKRWAVERGVNRVVDEVVDVRLNNRGYISNLLTKEGRTLEADLFIDCSGMRGLLINQALKEPFIDMSDYLLCDSAVASAVPNDDARDGVEPYTSSIAMNSGWTWKIPMLGRFGSGYVFSSHFTSRDQATADFLKLWGLSDNQPLNQIKFRVGRNKRAWVNNCVSIGLSSCFLEPLESTGIYFIYAALYQLVKHFPDTSFDPRLSDAFNAEIVHMFDDCRDFVQAHYFTTSRDDTPFWLANRHDLRLSDAIKEKVQRYKAGLPLTTTSFDDSTYYETFDYEFKNFWLNGNYYCIFAGLGMLPDRSLPLLQHRPESIEKAEAMFASIRREAERLRTSLPTNYDYLRSLRDGDAGLSRGQRGPKLAAQESL,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-2ee1a4c2b1f11f0ca375,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATHPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-52558cb584c322ce06bc,1,MAANGSQRPIIAFMSDLGTTDDSVAQCKGLMHSICPGVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIRQAAKGGARGQWAGSGDGFERADGSYIYIAPNNGLLTTVLEEHGYIEAYEVTSTKVIPANPEPTFYSREMVAIPSAHLAAGFPLAEVGRRLDDSEIVRFHRPAVEISGEALSGVVTAIDHPFGNIWTNIHRTDLEKAGIGQGKHLKIILDDVLPFEAPLTPTFADAGAIGNIAFYLNSRGYLSLARNAASLAYPYNLKAGLKVRVEAR,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-07e9bba1c63a7a01f935,1,MSTAFDCIVLGGGPAGSTTAALVAEQGHKTLLLERAKFPRYHVGESLMPDTFFTLERLGVVEKLKDRGFIRKYSVQFVGQSGRESAPFYFLQHRDEEASVTWQVERGEFDQLLFENAAEKGADCRDQMRVTDVLLDGDRVCGVKAKHADGEEFTFESKVVVDGTGQSSLLASKFDLKENYQDLRNAAIWTYYKGAHRDEGKDEGATIILYTSDRKSWFWYIPLKDDLVSVGVVSENDYLLRRGVRPQEAFEEELKRCPAMKWRIENGMREGDFKVCRDFSYSAKEPAGNGWVLVGDALGFLDPIYSSGVFLALKSGEMAADAIHAGLEKNDLSKEQLGGWAPEFMHGMGLIRQLVYAFYNEKFNFGHFIREFPQHKGNLVDLLVGRVFRPGLEQVFVDMETWLEKQSTDENMDSSKMTSKA,O=C(O)c1ccc(O)cc1,O=C(O)c1ccc(O)cc1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-a3346b8b4c26feb607f8,1,MTRSKVAIIGGGPAGSVAGLTLHKLGHDVTIYERSAFPRYRVGESLLPGTMSILNRLGLQEKIDAQNYVKKPSATFLWGQDQAPWTFSFAAPKVAPWVFDHAVQVKREEFDKLLLDEARSRGITVHEETPVTDVDLSDPDRVVLTVRRGGESVTVESDFVIDAGGSGGPISRKLGVRQYDEFYRNFAVWSYFKLKDPFEGDLKGTTYSITFEDGWVWMIPIKDDLYSVGLVVDRSKSAEVREQGADAFYSSTLAKCAKAMDILGGAEQVDEVRIVQDWSYDTEVFSADRFFLCGDAACFTDPIFRRSVLFSQGVHLASQSAVSAAAAIDRITRHGDEKDAVHAWYNRTYREAYEQYHQFLASFYTFASFTEPDSEFWRKRRITESDDDRLTRKKWFESLAGNGPEDPSGTVASFRDRASTMIAIGRHQRPELSDDFSEAELNPARVRWISDLTKRLNSITRFKWTGGKAVLKQHYRVEPIGFRLEQREVLANGEGLDMAQYPMDDEARQIFQDLAEEEFGYKTLVKRLGAVGRQELSTQIVVRLMEAGLLTGYDAQGEKVFVQGRLHFGGVGVEYEV,CC(=O)CC(=O)S,CC(=O)CC(=O)S,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-e81d47bc1914daacdfe3,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,COc1cc(C=O)ccc1O,COc1cc(C=O)ccc1O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-27bb63ed6f711388cd6e,1,MIPAPLRNIVIVGGGTAGWMAAAAFARVLGPSFNVQLIESEQLGTIGVGEATVPHIKAFNNLLGIDEAEFVRQTQGSFKLGIEFVDWQRPGTSYIHGFGTQIGHPLGLLPFHQYWIKQQRRGKAQPLGAYTLNTVAATRGKFMTSAGDVPANSPLASIAYAYHFDASQYARFLRGYAEQRGVTRLEGLIEQVQLDAHTGSVQSVQLASGQVVSGDLFIDCSGFRGLLIEEALHTGYHDFTHWLPCDRALAVPCEKVGPPTPYTRSTARAAGWQWRIPLQHRTGNGYVYSSAHISDDEAAAALLANLDGTPLADPRPLRFTTGRRKQFWNRNVVALGLASGFLEPLESTSIHLIQSGISKLLELFPREGISPVLVQRYNDRLAFEFDRIRDFLVLHYHATERDDSAFWRHCRTMPITPELQTTLDLFRDSGRFYRNAEEMFAEISWVQVMVGQGILPQGYHPLVDQVPDTDAEGFLASVAQTISHCVDVMPTHQQFIDRYCRADPVR,c1ccc2[nH]ccc2c1,c1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-da4bb298d82e8b0c1cde,1,MGTVTTSDGTNIFYKDWGPRDGLPVVFHHGWPLSADDWDNQMLFFLSHGYRVIAHDRRGHGRSDQPSTGHDMDTYAADVAALTEALDLRGAVHIGHSTGGGEVARYVARAEPGRVAKAVLVSAVPPVMVKSDTNPDGLPLEVFDEFRAALAANRAQFYIDVPSGPFYGFNREGATVSQGLIDHWWLQGMMGAANAHYECIAAFSETDFTDDLKRIDVPVLVAHGTDDQVVPYADAAPKSAELLANATLKSYEGLPHGMLSTHPEVLNPDLLAFVKS,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-4753e699ede615170936,1,MSVEEFDVVVAGGGPAGSTVASLVAMQGYRVLLLEKEVFPRYQIGESLLPSTVHGVCRLLGVTDELAKAKFPVKRGGTFRWGARPEPWTFSFAVSSRMTGPTSFAYQVERARFDEILLNNAKRKGVVVREGCAVAGVIEEGERVTGLRYTDPDGGEREVSASFVIDASGNKSRLYSSVGGTRNYSEFFRSLALFGYFGGGTKRLPEPNSGNILSVAFDSGWFWYIPLRDSGLTSVGAVVRREMAEKIQGDREKAFNALIAECPLISEYLSGAQRVTAGKYGELRVRKDYSYHQTTFWRPGMVLVGDAACFVDPVFSSGVHLATYSGLLAARSINSVLAGDLDEKTALTEFEARYRREYGVFYEFLMSFYEMNVNEESYFWHAKKVTNNEHTELESFVELVGGVSSGEAALTAAARIAERSGEFAAAVDQVADSDDGSMVPLFKSQVVKQVMQEGGQVQMKAVLGEDAEPEVPLFPGGLVASPDGMKWLPYYPA,N[C@@H](Cc1ccc(O)cc1)C(=O)S,N[C@@H](Cc1ccc(O)cc1)C(=O)S,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-0038263cc90dfa55d621,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATHPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNCWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-a61c5cdf78281955d9ab,1,MKTSGHTSASDLSLGRRSLLLGGSSAALMLALPHPANAGTSEEPPTFDFDLDTDNYIKWVKPATDEQASQSPLWESVGSMDVTVILWMSRVGNLAVFDAVAPYHETAVGVYSRIPRRPSSESATNRNMNIAILYTQLHTFERLLPLGLRGPAGSLRAMMVGLGLDPDNKSEDLTTPVGIGNVAFKSVWNALKNDGMNVLGYEGGRKYNPLPWADYTGYEPVNTPFRLNNPSRWQPQLHAHNGRRPGGGPGDLGIYVSQHFVTPQIALTKPHIFTDPAQFPLAAPKHSDHTRPRDYKRSVDEILEASASLNDERKALAEVMDNKLWGIGYTSTVIGRKYDENNEMGVFGWAAWSLQHFLATFDALIAVWRNKRKYDTVRPVSAVRHVYGHSKVTAWGGAGMGTVNDIRATEWMPYLPTGDHPEYPSGSTSLCAAGAQTARRYFNSEELDWTLEFNAGTSAVEPETTPAKNLQLHFHTWAEFNKACAESRVWGGVHFRKTVQQSLIYGEQFGDLAHEFVNRHVKGNIKTDTRN,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-3a047b4a81effb2caf23,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,c1ccc(N2CCNCC2)cc1,c1ccc(N2CCNCC2)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-e5ce886c0b0869006dc9,1,MPGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWVRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYMEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,c1ccc2c3c([nH]c2c1)CNCC3,c1ccc2c3c([nH]c2c1)CNCC3,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-3873ecf4855ce373db4b,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Nc1ccc2ccccc2c1,Nc1ccc2ccccc2c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-b7b99ba738afaaf923fa,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPFGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-e97776493f213d50b346,1,MTASYLKAAFGDRIDITLVESGHIGAVGVGEATFSDIRHFFEFLGLKEKDWMPACNATYKLAVRFENWREKGHYFYHPFEQMRSVNGFPLTDWWLKQGPTDRFDKDCFVMASVIDAGLSPRHQDGTLIDQPFDEGADEMQGLTMSEHQGKTQFPYAYQFEAALLAKYLTKYSVERGVKHIVDDVREVSLDDRGWITGVRTGEHGDLTGDLFIDCTGFRGLLLNQALEEPFISYQDTLPNDSAVALQVPMDMERRGILPCTTATAQDAGWIWTIPLTGRVGTGYVYAKDYLSPEEAERTLREFVGPAAADVEANHIRMRIGRSRNSWVKNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKNFPAADWNSMHRDLYNSAVSHVMDGVREFLVLHYVAAKRNDTQYWRDTKTRKIPDSLAERIEKWKVQLPDSETVYPYYHGLPPYSYMCILLGMGGIELKPSPALALADGGAAQREFEQIRNKTQRLTEVLPKAYDYFTQLR,Nc1ccccc1C(=O)C[C@H](N)C(=O)O,Nc1ccccc1C(=O)C[C@H](N)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-f1ee529ef49111208f1c,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISAIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-4091f2c5c45d0cb95c6b,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLALHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-9674b1f53ad3b01c8b4e,1,MNVEQIDENLAKFLAERYTPESVAQLADRFHRFGFVKFDAANRLVPDELQTAVREECDLLIEQHKERRNLLLSTTGNTPRRMSVVKSEEIEKSELISTLSRSEVLLGFLAGITREEIIPEVSSDERYLITHQEFKSDTHGWHWGDYSFALAWALRMPPIEHGGMLQAVPHTHWDKSNPRINQTLCEREINTHGLESGDLYLLRTDTTLHRTVPLSEDSTRTILNMTWAAKRDLEKDLVGNDRWWENPEAEAARAVDNA,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D2:1]-[C;D2+:2]-[C;D2:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D2:3]
aries-halogenase-ff231d4dee9c91e9ead0,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,CNCCN1CCc2ccccc21,CNCCN1CCc2ccccc21,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-7e46d737fdcad87443ca,1,MNNPDALRKVCIVGGGTAGWIAAAVMAHHMKGRLFEIELVESDDIGTIGVGESTIPPFMELIAKLDIDEQDFVRQVQASFKLGIEFKDWFRKDESYFHPFGDVGQRVELSDFYQCWRKATLAGHDFPLQDFAPATVMAHAGRFMLPFKARNTPIAGASYALHVDAKRVAQFLRGHAEARGVKRTEGIVTDVALDARGFVSTLTLKDGRTIDADFFIDCSGFRALLIEKALGSGYTDWSNYLFCDRAIAAQTENVGPPRPYTLAEAQDAGWRWRIPLQHRTGNGHVYSSEFMSDEEATRILLEKVEGEVVAGPMVVPFRTGVREKIWHRNVLAIGLSSGFIEPLESTAIHLIYRGMDFFFRFLPDRHCDPALADEYNRRMVADYTEIRDFIVLHYCTTARDDTPFWRKCRDMDWPDSLKERVELFRSNGTLREGLDELFRSVSWFSVLEGMGIRPRTYHPLVDRIDEAMLYAGLDKAREQLAGFVRQLPTQQQFIDAHCRAEKVDLTRPVMAGV,O=[N+]([O-])c1ccc2[nH]ccc2c1,O=[N+]([O-])c1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-b51e45a12fbae3d0ee2b,1,MSTHFLGKVKFDEARLAEDLSTLEVAEFSSAYSDFACGKWEACVLRNRTGMQEEDIVVSHNAPALATPLSKSLPYLNELVETHFDCSAVRYTRIVRVSENACIIPHTDYLELDETFTRLHLVLDTNSGCANTEEDKIFHMGLGEIWFLDAMLPHSAACFSKTPRLHLMIDFEATAFPESFLRNVEQPVTTRDMVDPRKELTDEVIEGILGFSIIISEANYREIVSILAKLHFFYKADCRSMYDWLKEICKRRGDPALIEKTASLERFFLGHRERGEVMTY,O=C(O)[C@@H]1CCCN1,O=C(O)[C@@H]1CCCN1,[C;D2:1]-[C;D2+:2]-[C;D3:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D3:3]
aries-halogenase-0f8e631d28e2a339b435,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)ccc1Oc1ccncc1,Cc1cc(N)ccc1Oc1ccncc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-05fb3c9a7f20d8c60ade,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,Nc1ccc2c(c1)C(=O)CCCC2,Nc1ccc2c(c1)C(=O)CCCC2,[C;D1+:1]=[O;D1+:2]>>[C;D1+:1]-[O;D1+:2] || [c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-8012472a35fd40939e08,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVWTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,CCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-8e57858ab42fef1ee804,1,MSAETFDVVVAGGGPAGSTAASLVAMQGHRVLLVEKEVLPRHRVGESLLPSTVHGVCRMLGVTDELAETDFPVKRGATFQWGGRAEPWAFSFGASSRLTDATSFAYQADRARFDEILLKNAKRKGVVVREGCSVTAVVEEGDRVTGLRHTDPDGGEHEVGARFVIDASGHESPLSASVGGTRDRAGSFRGLALSGYFGNGCKRLPEPRSGDGLSVTFDGGWFWYVPLFGGLTSVGAVVSEERAEKLQDDREEAFKALIAECPAISDLLSEGMRVTAGKYGKLRVREDYVYHRTTFWRPGMLLVGDAACSVDPLFSSGVHLATYSALLAARSINSVLAGDVDEKTALTEFEARYRRELGAFSELLTTFHTMTGEEHPEPESFVDVAAGVSSGEWALAAQGGGAAAPGEPMFRGGLAVSPDGMKWLPAASKEREDAR,N[C@@H](Cc1ccc(O)cc1)C(=O)S,N[C@@H](Cc1ccc(O)cc1)C(=O)S,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-67aa578ed1fd0fa4198a,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,Nc1ccc2nn[nH]c2c1,Nc1ccc2nn[nH]c2c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-22fc91dc876c50db64ef,1,MSTHFLGKVKFDEARLAEDLSTLEVAEFSSAYSDFACGKWEACVLRNRTGMQEEDILVSHNAPALATPLSKSLPYLNELVETHFDCSAVRYTRIVRVSENACIIPHTDYLELDETFTRLHLVLDTNSGCANTEEDKIFHMGLGEIWFLDAMLPHSAACFSKTPRLHLMIDFEATAFPESFLRNVEQLVTTRDMVDPRKELTDEVIEGILGFSIIISEANYREIVSILAKLHFFYKADCRSMYDWLKEICKRRGDPALIEKTASLERFFLGHREHGEVMTY,O=C(O)[C@@H]1CCCN1,O=C(O)[C@@H]1CCCN1,[C;D2:1]-[C;D2+:2]-[C;D3:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D3:3]
aries-halogenase-c4c9f099e7a471df3389,1,MNQYDVIIIGSGIAGALTGAVLAKSGLNVLILDSAQHPRFSVGEAATPESGFLLRLLSKRFDIPEIAYLSHPDKIIQHVGSSACGIKLGFSFAWHQENAPSSPDHLVAPPLKVPEAHLFRQDIDYFALMIALKHGAESRQNIKIESISLNDDGVEVALSNAAPVKAAFIIDAAAQGSPLSRQLGLRTTEGLATDTCSFFTHMLNVKSYEDALAPLSRTRSPIELFKSTLHHIFEEGWLWVIPFNNHPQGTNQLCSIGFQFNNAKYRPTEAPEIEFRKLLKKYPAIGEHFKDAVNAREWIYAPRINYRSVQNVGDRFCLLPQATGFIDPLFSRGLITTFESILRLAPKVLDAARSNRWQREQFIEVERHCLNAVATNDQLVSCSYEAFSDFHLWNVWHRVWLSGSNLGSAFLQKLLHDLEHSGDARQFDAALEAVRFPGCLSLDSPAYESLFRQSCQVMQQAREQARPVAETANALHELIKEHEAELLPLGYSRISNRFILKV,Oc1cc(O)cc(O)c1,Oc1cc(O)cc(O)c1,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-3cc16f8f6eede20fc562,1,MDVPLMELSGRAPVVRLHDIEADMAAATDAIRSQLTGWGFMAAEVPGIGERVEAMMNEFAAACRATGPSLSDYAYDVVPQLAVGGTHGFFPYNSEIPRLANGVPDPKEFIHVSGAMIGDQPPGAGDVLRAFPAFGTRAAEVFDIAFRLISLFGEVVRGMMPPGTPELDLSHDATNLRVIHYRDVGDREVLAHEHSGIQMLGLQLPPSDQGLQYVLHDGTWVEPVIAGTDVVLCNIGRMLTSASDGRFRPSTHRVHTKPMPAGYERLSSVLFAYPQHKARQWKMVDGELMSLNATWGDFIDSRFQGLGKQS,Nc1ncnc2c1ncn2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O)O1,Nc1ncnc2c1ncn2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O)O1,[C;D3:1]-[C;D2+:2]-[C;D3:3]>>[C;D3:1]-[C@;D3+:2](-[Cl;D1:4])-[C;D3:3]
aries-halogenase-4ab34cdf3e765ab1629e,1,MQPDFDAAIVGGGPAGSAMASYLAEAGLSVAVFESEMFPRPHIGESLVPATMPVLDEIGVMPDIEAAGFPKKYGAAWTSAESRDVPHNGFTGLDHDFKAAEVMFVERDQPGVHRDYTFHVDRGKFDLILLKHAESRGAQVFQKTRVLKADFDTDPDLVTLNCRLGPRTLDFTTRMVIDASGRQTMLGNQLKVKVPDPVFNQYAIHAWFEGLDRTAMALDPAKRDYIYVHFLPLEDTWMWQIPITDTITSVGVVTQKHRFKAASADREKFFWDIVSSRKDIYDALQKAERIRPFKAEGDYSYAMRQICGDRFLLIGDAARFVDPIFSSGVSVALNSARLAAKDVIAAHRAGDFRKESFATYEEKLRRAVRNWYEFISVYYRLNILFTAFVQDPRYRIDVLKMLQGDFYDGEEPKALKAMRDLVTKVENDPEHLWHPYLGTLRAPSAAPTF,COc1cccc(C)c1C(=O)S,COc1cccc(C)c1C(=O)S,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-14c54242e8185b507bc9,1,MSDSERSSVLGTPLGRRSLLVGGASAASLSMLALSRPALAATGDEPPELPDLDKDNYIKWAQPTGPRTGKSASDAFIGTMDVTVILFMNRAAMLALFDAVAPYHETAVGVHTKIPRRPASESATNRNMNIACIYAQRGIWSQLLPRNLEPLRELMLGLGLDPDDWSEDVTTPVGIGNTAAKSVWNVLKNDGMNALGHEGGRKYNPRPWADYTGYVPTNTAFELNNPSRWQPQLQAHNARRAGGGPGDLGIYVTQHFVTPQIAVTMPHIFKDPAEFQLARPDFSDHTDPRAYKRSVDEIIEASAALDDERKALAEIMENKLWGIGHSSIEVGLANDQNNELGVHGWAQWMLTHILATFDTLIAAWRYKRMYEAVRPITAVRHVYGSRKITAWGGVGMGTVDDIPADQWAGFLPVGDHPEYPSGSTTVGSAASQAARRFFDSDELNWEFDFEVGKSIVEPGITPVENVRVSFPTWTDFDKRCAYSRVDGGVHFKKTVERSMVFGEQFGDLANEFVARYVKGEGSGKG,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-9eb2d543a0a36152b007,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATMPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPFGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-64ef8cbfd4e16b46fba5,1,MINSVLIVGGGTAGWMTAAYLSKAFDKNINITVVESKEVKKIGVGEATFSTVRHYFDYLGLNESEWLPECSGSYKLGIRFENWDGQGNHFYHPFERWEVVKGFPISEWWLSKKLKDQRFDYDTFLTPHLCEAKRSPRRLDGSLFAQSIDKSLGQSTLAEQRAQYPYAYHFDADGVASFLKRYAMNRGVKHIEDDVTHVEIDTNGNIGYLEAKIYGKLRADLYIDCTGFKGLLINKALNEPFISFSDVLKNNRAVALRVPRENENDIEPYTTARTMSNGWRWTIPLYKRNGYGYVYCNKYQSPEEAEMELRKSIPYENAECVANHIRMRIGRSNRSWVKNCVAIGLSSAFVEPLESTGIFFIQHGIEQLVRFFPRSSGNELLIEEYNTRVNRVVDGVKEFLLLHFSLAQRNDTLYWKEWKNVELPKELLKKITLAQDHLLDKETIYPFYHGFEEYSWNTMILGLCSGSLNNKPALSLMTSDEADEMLLQHYMKAENMVNNLPTCYEYLKHIHDLKNKN,N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O,N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-b366c0efba99d592b8ed,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,COC(=O)c1ccc(N)cc1O,COC(=O)c1ccc(N)cc1O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-35ea9e03d5f2f4658cb5,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVATNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,CCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-78f9110cf588bd30afae,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKDLRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEGFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-1aa3e4f8f4a38d99994d,1,MGIPADNLQSRAKASFDTRVAAAELALARGAVPSFANGEELLYRNSETGDPSFIGSFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIAALTLGPARDPETGLPIWRSDLANSLDLEVRGWENSSAGLTFDLEGPDAQSVAMPPAPVLTSPELIAEMAELYLMALGRDIEFSEFDSPKNAAFIRSAIERLNGLEWFNTPAKLGDPPAEIRRRRGEVTVGNLFRGILPGSEVGPYLSQFIIVGSKQIGSATVGNKTLVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLDVQDAADFRGFESYEPGARLIRTIRDLATWVHFDSLYEAYLNACLILLANGVPFDPNLPFQQEDKLDNQDVFVNFGSAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKNAFLKSESVFPEVDVLVEELSSILDDSASSNEKQNIADGDVSPGKSFLLPMAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDANFQIDQVFEVDTDEDKLVKSSFPGPLTVAGELNKLADNVAIGRNMAGVHYFSDQFESLLLGEQIAIGILEEQSLTYGENFFFNLPKFDGTTIQI,CC(=O)OCC=C(C)CCC=C(C)C,CC(=O)OCC=C(C)CCC=C(C)C,[C;D1+:1]-[C;D2+:2]=[C;D1+:3].[C;D1+:4]=[C;D1+:5]>>[C;D1+:1]=[C;D2+:2]-[C;D2+:3]-[C;D2+:5]-[C;D2+:4]-[Br;D1:6]
aries-halogenase-451b01cbb6bdda2450c4,1,MTGTDSRIQKVVILGGGTAGWMTAAYLGKALQGTVDITVLEAPAIPRIGVGEATVPNLHKVLFDYLGIAEEEWMRECNASFKMAVRFVNWRTGGQGQPDARELENGGPDHFYHPFGILPDSDNVPMSHYWAKRKLEGRTEEPFDYACFREPPVMDAKKSPKWLDGTPSTRYAWHFDAALVADFLRRFATEKQGVNHVQDEMTHAEKDERGFIKALHTKAGRVLDADLFVDCSGFRGLLINQALEEPFIDMSDHLLCDSAVATAVPHDDEANGIEPYTSAIAMSSGWTWKIPMLGRFGSGYVYSSKFTTKEEATREFSALWGLDPETTKFNHVKFRVGRNRRAWVNNVVSIGLSSAFLEPLESTGIYFITAAIYQLAKHFPDRTFNPELANSFNHEIEVMFDDTRDFIQAHFYYAPRNDTPFWRANKELTLPKNIQEKISAYKAGLAINSPIADESTYYGNFEAEFRNFWTNGSYYCVFAGLGLEPDAPLPILAHKPESVAGAEALFGKVKQEQNHLLDTLPSTYDYLRKLHG,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-be322fb77d654ad524a7,1,MNQYDVIIIGSGIAGALTGAVLAKSGLNVLILDSAQHPRFSVGEAATPESGFLLRLLSKRFDIPEIAYLSHPDKIIQHVGSSACGIKLGFSFAWHQENAPSSPDHLVAPPLKVPEAHLFRQDIDYFALMIALKHGAESRQNIKIESISLNDDGVEVALSNAAPVKAAFIIDAAAQGSPLSRQLGLRTTEGLATDTCSFFTHMLNVKSYEDALAPLSRTRSPIELFKSTLHHIFEEGWLWVIPFNNHPQGTNQLCSIGFQFNNAKYRPTEAPEIEFRKLLKKYPAIGEHFKDAVNAREWIYAPRINYRSVQNVGDRFCLLPQATGFIDPLFSRGLITTFESILRLAPKVLDAARSNRWQREQFIEVERHCLNAVATNDQLVSCSYEAFSDFHLWNVWHRVWLSGSNLGSAFLQKLLHDLEHSGDARQFDAALEAVRFPGCLSLDSPAYESLFRQSCQVMQQAREQARPVAETANALHELIKEHEAELLPLGYSRISNRFILKV,Oc1cccc(O)c1,Oc1cccc(O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-98b1690510df1bf21fe1,1,MDEIDDPRIRSVVIVGGGTAGWMTAAALVQHFRTAPLKITVVESSDIGTIGVGEATIPTIRRFYGQLGLRDDDVMRATQATCKLGIRFLDWSGPGSDFIHPFGLYGQDVKGIGFHHYWLKQRRAGDAAPLAAYSLGAALAAGGKFTLPSPHPPSQLSVFDWALHLDAGLFAQHLRAYAEAGGCARIDARIRSVELRPEDGFVRALTLDDGREVEGDLFVDCSGFKGLVIGEALGVGFEDWGRWLPCDAAYAVQSENRPGDAPAPFTRVTARSAGWQWGIPLRHRAGNGLVFSSAHLSDDQALAELMPHLLGDPLTEPRRIPFRPGRRSQAWAKNCVAIGLSSGFLEPLESTSIALIETGIERLKALFPDRRFAQPILDEFNDQTAREMERVRDFIILHYKLNRRTDTDFWRDCREMPVPETLERKIALWTARGQFVRYRWEMFHPASWLAIYDGFGLYPDHHDPAVDAMDPAYLARSLAEMRANIADLVARTPEHAQFLAGLDPAASAA,Cc1ccc2[nH]ccc2c1,Cc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-30606ac3b4fd5c618ac4,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLEGSGIYFIYAAIHMLARHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-04e17d3132b946c48d0a,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,N#Cc1ccc(Oc2cccc(N)c2)cc1,N#Cc1ccc(Oc2cccc(N)c2)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-35fcdee9b9238f7ed41a,1,MGIPADNLQSRAKASFDTRVSAAELALARGSVPSFANGEELLYRNPDPDNDDPSFIASFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIADLTLGPARDPDTGLPIWRSDLANSLELEVRGWENSSAGLTFDLEGPDAQSIAMPPAPVLTSPELVAEIAELYLMALGREIEFSEFDSPKNAEYIQFAIDQLNGLEWFNTPAKLGDPPAKIRRRRGEVTVGNLFRGILPGSEVGPYLSQYIIVGSKQIGSATVGSKTLVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLDVQDAADFRGFESYEPGARLIRTIRDLATWVHFDALYEAYLNACLILLANRVPFDPNIPFQQEGKLDNQDVFVNFGDAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKIAAEKGESIFPEVDLAVEELGDILEKAEISNRKQNIADGDPDPDPSFLLPMAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDSNFQIDQVFEVDKDEDKLVKSSFKGTLTVAGELNKLADNIAIGRNMAGVHYFSDQFESLLLGEQVAIGILEEQSLTYGENFFFNLPKFDGTTIQI,CC(=O)CCC=C(C)CCC=C(C)C,CC(=O)CCC=C(C)CCC=C(C)C,[C;D1+:1]-[C;D2+:2]=[O;D1+:3].[C;D1+:4]=[C;D1+:5].[C;D1+:6]=[C;D1+:7]>>[C;D1+:1]=[C;D2+:2]-[O;D2+:3]-[C;D2+:7]-[C;D2+:6]-[C;D2+:5]-[C;D2+:4]-[Br;D1:8]
aries-halogenase-507c38cb8a975a83bafb,1,MDAEFDIGIIGGGPAGSTAASYLAKAGLKVAVFEAETFPREHVGESLVPATTPVLIETGAMPKVEAANFPKKFGAAWTSAEDRNIDHNGFRGLTHDFRAAEILFNERDQDGVDRDYTFHVDRGKFDQILLQHAESLGAKVFHGIRIGKVDFDGEMPVLEAKIGSKSVDIPVRMVVDASGRQTRLGNQLKFKVPDPIFNQYAVHSWFDNFDRKALAVNKDQADYIFIHFLPVTDTWVWQIPITDTITSIGVVSQKKRFQEFAGDREKFFWDTVASRPELLDALKNSDQVRPFKTEGDYSYGMSQIAGDNFVLIGDAARFVDPIFSSGVSVALNSARLACKDIIAAAEAGDFKKERFGTYERKLRKGVSNWYEFIQIYYRLNILFTAFVQDDRYRLDVLKMLQGDVYDDEEPKALAAMREIVKAVEDDPTHLWHPYLGSLKAPSAKPQF,O=C(S)c1ccc[nH]1,O=C(S)c1ccc[nH]1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-85a0c85aa37d722d2188,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMVINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,CC(C)NCC(O)COc1cccc2[nH]c3ccccc3c12,CC(C)NCC(O)COc1cccc2[nH]c3ccccc3c12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-ee0d6c299a70d20946c1,1,MTTNTPTTGVRTLDQDAFDRHLKEFSENAPILEYSQAFRREGYVKLTGLVSADLFAEVVSEVGDLLDQHAQRIDIELKETGNSPRRMHTVSAADIARDSRLISAIYDSASIRDTLGRIAQADVRPCPWEGEKYVIIRQDQPGDTHGWHWGDFSYTLIWIIQAPGPEVGGMLQCVPHTNWDKQNPRVHEYLQNHPIRTYANATGDLYFLRSDTTLHRTIPLSRPATRIILNTCWASTADVERPTTHETMDAMFSS,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D0+:1]>>[C;D2+:1](-[Cl;D1:2])-[Cl;D1:3]
aries-halogenase-a7bb4472588958f3423a,1,MNTRRQQAQNIRNNAAELAANRPHPQHINNKEEYEYRRPKKDGNEPSHIANFTKGLPHDEHTGLLLNSADYDQFVLGIQSGDTTDFARTPLGPAELPKVHGCLSKQKIDCDDDHRSGFWKSQIAQGAAGGDGAKLRAWESAGAGLVFDLEGPDAQAVTMPPAPRLESPELTSEIAEVYSQALLRDIHFSQLRDPGLGDQVNACDSCPTQLSIYEAIDILNTVQIEGQNWFSANCCDLTDDEQARQRPLVTRQNIFRGIAPGDDVGPYLSQFLLIGNNALGGGVFGQEAGHIGYGAIRIDQRVRKATPCKDFMTNFETWLDVQNGADLRGLETYVDADPGKCREFPAYRVITTPRDLATYVHYDALYEAYLNACLILLGMGAPFDPGIPFQKPDVEDKQQGFAHFGGPQILTLVCEAATRGLKAVRFQKFNVHRRLRPEALGGLVDRYKHGKGAGDELKPVAALVEALENVGLLSKVVAHNQLQNQNLDRSGDPSSAGDNYFLPMAFPEGSPMHPSYGAGHATVAGACVTMLKAFFDHGWQLNLGMANGKYISYEPNQDGSSLQQVLLDCPLTVEGELNKIAANISIGRDWAGVHYFTDYIESLRLGEKIAIGILEEQKLTYGENFTMTVPLYDGGSIQI,Nc1ccccc1,Nc1ccccc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-36c321ad538f860b4e28,1,MNNPDALRKVCIVGGGTAGWIAAAVMAHHMKGRLFEIELVESDDIGTIGVGESTIPPFMELIAKLDIDEQDFVRQVQASFKLGIEFKDWFRKDESYFHPFGDVGQRVELSDFYQCWRKATLAGHDFPLQDFAPATVMAHAGRFMLPFKARNTPIAGASYALHVDAKRVAQFLRGHAEARGVKRTEGIVTDVALDARGFVSTLTLKDGRTIDADFFIDCSGFRALLIEKALGSGYTDWSNYLFCDRAIAAQTENVGPPRPYTLAEAQDAGWRWRIPLQHRTGNGHVYSSEFMSDEEATRILLEKVEGEVVAGPMVVPFRTGVREKIWHRNVLAIGLSSGFIEPLESTAIHLIYRGMDFFFRFLPDRHCDPALADEYNRRMVADYTEIRDFIVLHYCTTARDDTPFWRKCRDMDWPDSLKERVELFRSNGTLREGLDELFRSVSWFSVLEGMGIRPRTYHPLVDRIDEAMLYAGLDKAREQLAGFVRQLPTQQQFIDAHCRAEKVDLTRPVMAGV,Cc1ccc2[nH]ccc2c1,Cc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-4aa7c75f447a322ef688,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,C=CC(C)(C)c1[nH]c2ccccc2c1CCNC,C=CC(C)(C)c1[nH]c2ccccc2c1CCNC,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-52a6932d5af5316a815a,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWTNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,c1ccc2c3c([nH]c2c1)CNCC3,c1ccc2c3c([nH]c2c1)CNCC3,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-6793f9e266ce6ebd9638,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIALNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-501883ce12ba20f1a0de,1,MSVPNKTTVLVIGGGPAGSYAAAVLARENVDTVLLEAEKFPRYHIGESMLASMRFFLRFIDLEEQFDAYGFQKKYGATFKINSKREAYTDFSASLGPGGYAWNVIRSEADDLIFRYAGEQGAHIFDGTKVDDIEFLSYDGADGANFTPAAFLVNPGRPVAATWSRKDGTRGRIKFDYLIDASGRAGIISTKYLKNRTVNEGLRNIANWSYWKGAKVYGEGSDQQGSPFFEALTDGSGWCWAIPLHNGTLSVGVVMRQDLFFGKKKAAGSPGSLEMYKLCLQSVPGISGLLEDAEIVSDVKMASDWSYSASAYAGPHFRVAGDAGCFIDPYFSSGVHLALVGGLSAATTIQAVRRGETSEFSAAKWHSSKVTEGYTRFLLVVMAVLRQLRKQNAAVITDDKEEGFDTAFGLIQPVIQGQADTGESEQQRMVAGVQFSLERFGQATPEAQRALLDKVQFAGQNAEELEKLTADELAVLHNIIGRQLKMTKVEKNLDNFTRDVIDGWAPRVERGKLGLQRADTSIMTAEMKDLFQLNRSLDSTKAGIQLPA,COC(=O)c1cc(O)cc(OC)c1C(=O)c1c(O)cc(C)cc1O,COC(=O)c1cc(O)cc(OC)c1C(=O)c1c(O)cc(C)cc1O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-930f7bc78c2340e72256,1,MSVEDFDVVVAGGGPGGSTVATLVAMQGHRVLLLEKEVFPRYQIGESLLPATVHGVCRMLGVADELAGAGFPIKRGGTFRWGARPEPWTFHFGISAKMAGSTSHAYQVERARFDEILLNNAKSKGVVVREGCSVHDVVEDGERVTGAKYTDPDGNEREVSARFVIDASGNKSRLYSKVGGSRNYSEFFRSLALFGYFEGGKRLPEPVSGNILSVAFDNGWFWYIPLSDTLTSVGAVVRREDADKIQGDREKALNALIAECPLISEYLSNATRVTTGKYGELRVRKDYSYQQETYWRPGMVLVGDAACFVDPVFSSGVHLATYSALLAARSINSVLAGDLDEKTALNEFEARYRREYGVFYEFLVSFYQMNVNEESYFWQAKKVTQNQSTDIESFVELIGGVSSGETALTAADRIAARSAEFAAAVDEMAGGDGDNMVPMFKSTVVKQAMQEAGQVQMKALLGEDAEPELPLFPGGLVTSPDGMKWLPHHPA,CC(C)C[C@H](C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)S)c1ccc(O)cc1)c1ccc(O)cc1)C(C)N,CC(C)C[C@H](C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)S)c1ccc(O)cc1)c1ccc(O)cc1)C(C)N,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-8e93e440f571a4dac326,1,MTDFDIGIIGGGPGGTTAASYLARAGLSVAVFEGELFPREHVGESLVPATTPVLREIGALAKLDEAGFPRKYGAAWTSPSGARASDTFGMADLAFAEDEDVLGGQSYTYHVDRGRFDQLLLEHSSTLGAKVFEGARVRRVDFDGPHPRIVHASGGSESRTGVRMVIDASGRGTLLGRQLGLKVTDPTFDQYAVHGWFTGLDREAIAGRDALADYLFVHFLPAEDSWVWQIPITDTITSVGVVSRKSRLRQAGGDREAFFWGTLEHRPELAAALRACTPVRPLKVDGDFSYAMRQITGDGWAMVGDAARFVDPIFSSGVGIAMNGARLLSQDVLAAAEAGDFARQRFAEYEKKQRRGLTNWYNFIAVYYRLNILFTVFVQDPRYRLDVLRMLQGNVYETDHPPVLTTMQGVVETVESNPDHLWHPHLGSLRAPAAAPLF,Nc1ncnc2c1ncn2[C@@H]1O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]1O,Nc1ncnc2c1ncn2[C@@H]1O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]1O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-285f8e7a01879313d77a,1,MIPAPLRNIVIVGGGTAGWMAAAAFARVLGPSFNVQLIESEQLGTIGVGEATVPHIKAFNNLLGIDEAEFVRQTQGSFKLGIEFVDWQRPGTSYIHGFGTQIGHPLGLLPFHQYWIKQQRRGKAQPLGAYTLNTVAATRGKFMTSAGDVPANSPLASIAYAYHFDASQYARFLRGYAEQRGVTRLEGLIEQVQLDAHTGSVQSVQLASGQVVSGDLFIDCSGFRGLLIEEALHTGYHDFTHWLPCDRALAVPCEKVGPPTPYTRSTARAAGWQWRIPLQHRTGNGYVYSSAHISDDEAAAALLANLDGTPLADPRPLRFTTGRRKQFWNRNVVALGLASGFLEPLESTSIHLIQSGISKLLELFPREGISPVLVQRYNDRLAFEFDRIRDFLVLHYHATERDDSAFWRHCRTMPITPELQTTLDLFRDSGRFYRNAEEMFAEISWVQVMVGQGILPQGYHPLVDQVPDTDAEGFLASVAQTISHCVDVMPTHQQFIDRYCRADPVR,Cc1ccc2[nH]ccc2c1,Cc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-00f6112fe58387958ef8,1,MSTLSEHIDNAFDLSYLNFPKCPPTDIKTIGILGGGTAGYLAALALKKYHPEVEVTVIESSKIPVIGVGESTTTEIVPFLHRGLEIDPAEFFREVEPTLKFGIRFDWGCPGDYKFNFSFFAGHQYESYYYENDIKNSNWPSVLMNENKIPVIRNKNGTLTSFLASIPFSYHIDNKNLIRFLNKEVKSRGIDILDAEVHEVKLDERGYVASLESKEGHSLSYDLYIDCSGFRSKILGQALKTEFTPFTDTLVTDRALTFDMPNKDVVDCYTSVITMNNGWCWKIPMRTEDHYGYVFSSKFCDEETALAEARARFGHFEKYKMVEFRSGRHTQAWVKNVFSLGNSYGFIEPLESTAIQTAVHSINVLCRLMPKTLDDQISITGINNEIAVTWDTFRWFVGMHYKFNKKLDTPFWKHCREKTNIGHAQTIVNLFNQRPPLSAGNFGSNSQFTATEALVFNSYSYDTLIFGQKEVYKPLAAPEMSKEEYFGKLKSYQELTSRSLSLFELFKGDHLFEDEILEQLFNDTDTWIMEADV,CC(C)NCC(O)COc1cccc2[nH]ccc12,CC(C)NCC(O)COc1cccc2[nH]ccc12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-8e614d39a1f1279958da,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVFTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,CCCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CCCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-80f8ded29fa2e922c77b,1,MEANPTAGTEVVVIGAGIVGVHSAIQFAKRGLKVVLIDNIVGQKKSFKVGESLLVFSNMFLRTISELDEFNQKCFPKHGVWFTYGMEGTTSFEEKAEWALESTLPQAMRDAFANKALLRAMADDVQIVRPEAEELMQQTARAHPNITFLDTAKVTNVVIAEGGGPHEVTWECKATQRTGVVRTTWLIDCSGRNRLLAKKLKHAAEDVELNDGFKTTAVWGQFSGIKDEMFGENWVNRTSDGARSKRDLNTLHLWGDGYWIWVIRLSEGRISVGATYDQRRPPAGAGYREKFWDIIRRYPLFDGMLSDDNMLEFHVFKNCQHITDTFVSEKRYGMIGDAASVIDAYYSQGVSLALVTSWHITNIMERDLRERRLDKEYIARVNRHTRQDWHIMRNMVIEKYTSAMADGRFFVMTHLLDMIIFVGAAFPRYLLVRWLVETQGSTARETPVMREMRRYLEENLYYSKIGSLAPEKVQKVQRGLQASLSERARWRVENGVKVTRLKAIVHAPSGLLKFWKLPLSGQREFEDISPKPVKQIPKWLAMTGEETNPRMLKMARPLMASTFFLMYGYDGLSTAVTKVRQRLERLPGAAATAETTAAGRRGEAPEPAMNGAAPVRNVLREVSA,CC1=C[C@@H](C)[C@H]2[C@@H]3C(=O)CC(=O)CC(=O)O[C@@H](C)/C=C/C=C\[C@@H](C)[C@@H]3C=C[C@@H]2C1,CC1=C[C@@H](C)[C@H]2[C@@H]3C(=O)CC(=O)CC(=O)O[C@@H](C)/C=C/C=C\[C@@H](C)[C@@H]3C=C[C@@H]2C1,[C;D0+:1]>>[C;D2+:1](-[Cl;D1:2])-[Cl;D1:3]
aries-halogenase-8ba5ef4e282bf7bc5cf1,1,MINSVLIVGGGTAGWMTAAYLSKAFDKNINITVVESKEVKKIGVGEATFSTVRHYFDYLGLNESEWLPECSGSYKLGIRFENWDGQGNHFYHPFERWEVVKGFPISEWWLSKKLKDQRFDYDTFLTPHLCEAKRSPRRLDGSLFAQSIDKSLGQSTLAEQRAQYPYAYHFDADGVASFLKRYAMNRGVKHIEDDVTHVEIDTNGNIGYLEAKIYGKLRADLYIDCTGFKGLLINKALNEPFISFSDVLKNNRAVALRVPRENENDIEPYTTARTMSNGWRWTIPLYKRNGYGYVYCNKYQSPEEAEMELRKSIPYENAECVANHIRMRIGRSNRSWVKNCVAIGLSSAFVEPLESTGIFFIQHGIEQLVRFFPRSSGNELLIEEYNTRVNRVVDGVKEFLLLHFSLAQRNDTLYWKEWKNVELPKELLKKITLAQDHLLDKETIYPFYHGFEEYSWNTMILGLCSGSLNNKPALSLMTSDEADEMLLQHYMKAENMVNNLPTCYEYLKHIHDLKNKN,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-03b0bd366e8184f8d871,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATMPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPFGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-6ed701cfedb16ebd91b2,1,MGIPADNLQSRAKASFDTRVSAAELALARGSVPSFANGEELLYRNPDPDNDDPSFIASFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIADLTLGPARDPDTGLPIWRSDLANSLELEVRGWENSSAGLTFDLEGPDAQSIAMPPAPVLTSPELVAEIAELYLMALGREIEFSEFDSPKNAEYIQFAIDQLNGLEWFNTPAKLGDPPAKIRRRRGEVTVGNLFRGILPGSEVGPYLSQYIIVGSKQIGSATVGSKTLVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLDVQDAADFRGFESYEPGARLIRTIRDLATWVHFDALYEAYLNACLILLANRVPFDPNIPFQQEGKLDNQDVFVNFGDAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKIAAEKGESIFPEVDLAVEELGDILEKAEISNRKQNIADGDPDPDPSFLLPMAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDSNFQIDQVFEVDKDEDKLVKSSFKGTLTVAGELNKLADNIAIGRNMAGVHYFSDQFESLLLGEQVAIGILEEQSLTYGENFFFNLPKFDGTTIQI,CC(C)=CCCC(C)=CCO,CC(C)=CCCC(C)=CCO,[C;D1+:1]-[C;D2+:2]=[C;D2+:3]-[C;D2:4].[C;D1+:5]=[C;D2+:6]-[C;D2:7]>>[C;D1+:1]=[C;D2+:2]-[C@@;D3+:3](-[C;D2:4])-[C;D2+:5]-[C@@;D3+:6](-[Br;D1:8])-[C;D2:7]
aries-halogenase-d212b2ac736e3f60408f,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-9baed8fceea6e36d3667,1,MNKPIKNIVIVGGGTAGWMAASYLVRALQQQANITLIESAAIPRIGVGEATIPSLQKVFFDFLGIPEREWMPQVNGAFKAAIKFVNWRKSPDPSRDDHFYALFGNVPNCDGVPLTHYWLRKREQGFQQPMEYACYPQPGALDGKLAPCLSDGTRQMSHAWHFDAHLVADFLKRWAVERGVNRVVDEVVDVRLNNRGYISNLLTKEGRTLEADLFIDCSGMRGLLINQALKEPFIDMSDYLLCDSAVASAVPNDDARDGVEPYTSSIAMNSGWTWKIPMLGRFGSGYVFSSHFTSRDQATADFLKLWGLSDNQPLNQIKFRVGRNKRAWVNNCVSIGLSSCFLEPLESTGIYFIYAALYQLVKHFPDTSFDPRLSDAFNAEIVHMFDDCRDFVQAHYFTTSRDDTPFWLANRHDLRLSDAIKEKVQRYKAGLPLTTTSFDDSTYYETFDYEFKNFWLNGNYYCIFAGLGMLPDRSLPLLQHRPESIEKAEAMFASIRREAERLRTSLPTNYDYLRSLRDGDAGLSRGQRGPKLAAQESL,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-9113b98df80f877c7a2e,1,MDEIDDPRIRSVVIVGGGTAGWMTAAALVQHFRTAPLKITVVESSDIGTIGVGEATIPTIRRFYGQLGLRDDDVMRATQATCKLGIRFLDWSGPGSDFIHPFGLYGQDVKGIGFHHYWLKQRRAGDAAPLAAYSLGAALAAGGKFTLPSPHPPSQLSVFDWALHLDAGLFAQHLRAYAEAGGCARIDARIRSVELRPEDGFVRALTLDDGREVEGDLFVDCSGFKGLVIGEALGVGFEDWGRWLPCDAAYAVQSENRPGDAPAPFTRVTARSAGWQWGIPLRHRAGNGLVFSSAHLSDDQALAELMPHLLGDPLTEPRRIPFRPGRRSQAWAKNCVAIGLSSGFLEPLESTSIALIETGIERLKALFPDRRFAQPILDEFNDQTAREMERVRDFIILHYKLNRRTDTDFWRDCREMPVPETLERKIALWTARGQFVRYRWEMFHPASWLAIYDGFGLYPDHHDPAVDAMDPAYLARSLAEMRANIADLVARTPEHAQFLAGLDPAASAA,Fc1ccc2[nH]ccc2c1,Fc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-7931aa2a1bed855457d1,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,Oc1cnc2ccccc2c1,Oc1cnc2ccccc2c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-da6e2f539726fabd1f8c,1,MDEIDDPRIRSVVIVGGGTAGWMTAAALVQHFRTAPLKITVVESSDIGTIGVGEATIPTIRRFYGQLGLRDDDVMRATQATCKLGIRFLDWSGPGSDFIHPFGLYGQDVKGIGFHHYWLKQRRAGDAAPLAAYSLGAALAAGGKFTLPSPHPPSQLSVFDWALHLDAGLFAQHLRAYAEAGGCARIDARIRSVELRPEDGFVRALTLDDGREVEGDLFVDCSGFKGLVIGEALGVGFEDWGRWLPCDAAYAVQSENRPGDAPAPFTRVTARSAGWQWGIPLRHRAGNGLVFSSAHLSDDQALAELMPHLLGDPLTEPRRIPFRPGRRSQAWAKNCVAIGLSSGFLEPLESTSIALIETGIERLKALFPDRRFAQPILDEFNDQTAREMERVRDFIILHYKLNRRTDTDFWRDCREMPVPETLERKIALWTARGQFVRYRWEMFHPASWLAIYDGFGLYPDHHDPAVDAMDPAYLARSLAEMRANIADLVARTPEHAQFLAGLDPAASAA,Cc1cc2ccccc2[nH]1,Cc1cc2ccccc2[nH]1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-6557739a67283a8de383,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNPWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-b20a51d1d0cd4d4e2f5c,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,CN(C)CCN1CCCc2ccccc21,CN(C)CCN1CCCc2ccccc21,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-1a95046e1c6e0db1f4cc,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVWTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,CCCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CCCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-e0ccc43c9b15159c7ad9,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREVEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-baffc1e34bdd807d7617,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,Cc1ccccc1NC1CCNCC1,Cc1ccccc1NC1CCNCC1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-6589ed9b9dd4caa59d93,1,MNIACIHAQNAIWSRLLPPIVAGLRELMVALGLDPDDKSEDVTTPVGIGNVAAKAVWNVLKNDGMNVLGHEGGRKYNPRPWADYTGYVPTNTAFKLNNPSRWQPQLQAHNGRRAGGGPGDLGIYVTQHFVTPQIAVTLPHIFKDPTAFPLPRPDFTDHTDRRAYKRSVDEIIEASAALDDERKALAEIMENKLWGIGHSSIEIGLKNDQNNELGVHGWAQWMLQHILATFDTLIAAWGYKRKYEAVRPITAVRHVYGNRKIRAWGGVGMGTVDDIPANEWAGYLPVGDHPEYPSGSTTVGSAASQAARRFFDSDDLNWEFDFEVGKSIVEPGITPVENVRVSFPTWTDFNKRCAYSRLDGGVHFKKTVERSMAFGEQFGDLAHDFIQRHVKGEGDG,CC(C)=CCC/C(C)=C/CC12OC(C)(C)[C@H](Cl)C[C@]1(Cl)C(=O)c1c(O)cc(O)cc1C2=O,CC(C)=CCC/C(C)=C/CC12OC(C)(C)[C@H](Cl)C[C@]1(Cl)C(=O)c1c(O)cc(O)cc1C2=O,[C;D1+:1]-[C;D2+:2]=[C;D2+:3]-[C;D2:4].[C;D1+:5]=[C;D2+:6]-[C;D2:7]>>[C;D1+:1]=[C;D2+:2]-[C@@;D3+:3](-[C;D2:4])-[C;D2+:5]-[C@@;D3+:6](-[Cl;D1:8])-[C;D2:7]
aries-halogenase-74e70910949899071b1e,1,MKTRAKAELSYYLSVEEKQFFRDNGYIGPFTLFQPEEILELWNEIRMDLLDRETAPFPNSKMNYDRHLDIQALSDIISHPKIAHRVSSLLGSNVLCWRTAWFPKYPGDEGTDWHQAESFVEFEGKSKLVPTESHDGPWELTAWVAFSEATRENGCMKVMPGTHNTWYFDEHRNIEFEPDKINQKLTGGKKTGVYGYDYYKLKLDPNWEPDESQAVHLEMEPGQFILFTSRCMHGSEPNTSGSSIRYGWSTRFVPTDVRVYPDWESFQHFGEVFPLERYATVLVAGEDTYKHNKIRRPLGQ,C[C@@H](C[C@H](N)C(=O)S)C(Cl)Cl,C[C@@H](C[C@H](N)C(=O)S)C(Cl)Cl,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-17dc3303cd10e0824497,1,MGVVSADQAHLEILNSNPYETRDFFWEQHRFARDGYLKINHLIDPLVRDAIMVDVKYLMAHHAKRRDFLIESTGNTPRYLSNVSRDNIEEFGRYIPLAYKSQYLMSLIGNIVKEEVIPTPWKWDNYIINSQHKSGDTHGWHWGDYPYTIIWIVEAPSIECGGLLECVPHTNWDKKNPRVENLLVENSIDSYFHITGDVYLLKADTTLHRVKPLTKDVQRIILNTTWERARDRDRHVEHETFVFRD,CCC(C)[C@H](N)C(=O)O,CCC(C)[C@H](N)C(=O)O,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-44c59909f17c296d6f2e,1,MHHHHHHSSGVDLGTENLYFQSNAMNREQVEQLKQEYEEKGYCQIKKIFDFSAIKTIQKTLDQAKQESQISKEKVTLKLGGIDDIDTNDHAYDLVKYDFVSSFIQEKLALLNYITGKNLMIMHNALFSVEPNHKGLPWHVGVGSFSFTKTEDFGASIWIPLDKITKEHRGGMQYVSTKIFPGQFYYSVFDLHLKNNIKWDESQGDLNEYVANANTIYNKITEDVIDYTIKDGYEEDEYNLGDAFFFNKYVLHQSVPLKPGLHKLRRAFVIRLVDYDTRVDEERLGLFSKYSQLHSRYYKTLPRYNKDSVLVMVSRAVQKGLKSPYLRDIPHVQQTLAARMAAGA,C[C@](O)(CC(=O)O)CC(=O)S,C[C@](O)(CC(=O)O)CC(=O)S,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-b3773ecbf7494c6f8e96,1,MSNNTVSTKPALHFLDINATEVKKYPTAIQDIIINRSFDGMIIRGVFPRDTMEQVARCLEEGNDGGMKSILNKNEEFGTKVAQIYGHAIVGQSPDLKDYFASSAIFRQACRTMFQGSPDFEEQVESIFHSLSELPVEIPTGPEGQTYTPATIRLLLEGREIAVHVGNDFLLMPAANHLKTLLDLSDQLSYFIPLTVPEAGGELVVYSLEWNPQEASKYAQMQEYMDDVESKIKSNQSQSVAYAPGPGDMLLFNGGRYYHRVSEVIGNSPRRTIGGFLAFSKQRDKIYYWS,C=C[C@]1(C)CC[C@H]2[C@@H](c3c([nH]c4ccccc34)C2(C)C)[C@H]1C#N,C=C[C@]1(C)CC[C@H]2[C@@H](c3c([nH]c4ccccc34)C2(C)C)[C@H]1C#N,[C;D2:1]-[C;D2+:2]-[C;D4:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D4:3]
aries-halogenase-3a6e2b22591ed55131de,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,COc1cc(C=O)cc(OC)c1O,COc1cc(C=O)cc(OC)c1O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-86748254b6bfcc91d1a9,1,MINSVLIVGGGTAGWMTAAYLSKAFDKNINITVVESKEVKKIGVGEATFSTVRHYFDYLGLNESEWLPECSGSYKLGIRFENWDGQGNHFYHPFERWEVVKGFPISEWWLSKKLKDQRFDYDTFLTPHLCEAKRSPRRLDGSLFAQSIDKSLGQSTLAEQRAQYPYAYHFDADGVASFLKRYAMNRGVKHIEDDVTHVEIDTNGNIGYLEAKIYGKLRADLYIDCTGFKGLLINKALNEPFISFSDVLKNNRAVALRVPRENENDIEPYTTARTMSNGWRWTIPLYKRNGYGYVYCNKYQSPEEAEMELRKSIPYENAECVANHIRMRIGRSNRSWVKNCVAIGLSSAFVEPLESTGIFFIQHGIEQLVRFFPRSSGNELLIEEYNTRVNRVVDGVKEFLLLHFSLAQRNDTLYWKEWKNVELPKELLKKITLAQDHLLDKETIYPFYHGFEEYSWNTMILGLCSGSLNNKPALSLMTSDEADEMLLQHYMKAENMVNNLPTCYEYLKHIHDLKNKN,NC(=O)Cc1c[nH]c2ccccc12,NC(=O)Cc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-77334823791bea53e508,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,c1ccc(Nc2nnc[nH]2)cc1,c1ccc(Nc2nnc[nH]2)cc1,[n;H;D2:1]>>[n;D2:1] || [n;D2:1]>>[n;H;D2:1] || [c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-81ea96707fb064365350,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,CNS(=O)(=O)Cc1ccc(N)cc1,CNS(=O)(=O)Cc1ccc(N)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-1523b662871b049a426f,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYRGNFEEEFRNPWSNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-93989d0f14e7ec638a3c,1,MDNRINRIVILGGGTAGWMTASYLAKALGDTVTITLLEAPAIGRIGVGEATVPNLQRVFFDFLGLREEEWMPECNAAFKTAVKFINWRTPGPGEAKARTIDGRPDHFYHPFGLLPEHGQVPLSHYWAYNRAAGTTDEPFDYACFAETAAMDAVRAPKWLDGRPATRYAWHFDAHLVAEFLRRHATERLNVEHVQGEMQQVLRDERGFITALRTVEGRDLEGDLFIDCSGFRGLLINKAMEEPFIDMNDQLLCNRAVATAIKHDDDAHGVEPYTSAIAMRSGWSWKIPMLGRFGTGYVYSSRFAEKDEATLDFCRMWGLDPENTPLNQVAFRVGRNRRAWVKNCVSIGLASCFLEPLESTGIYFITAAIYQLTQHFPDRTFALALSDAFNHEIEAMFDDTRDFIQAHFYVSPRTDTPFWKANKDLHLPEQMREKIAMYKAGLPINAPVTDESTYYGRFEAEFRNFWTNGSYYCIFAGLGLRPDNPLPMLRHRPEQVREAQALFAGVKDKQRELVETLPSNLEFLRSLHGK,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-815106adc7256d3f3e3c,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYRGNFEEEFRNPWSNGSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-52018340d5255b7d07ae,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYAGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-9d9f3c4ea93d3640e675,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVATNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,CCCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CCCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-f11a7d64cc0201a4ba1e,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNPWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-bfad68fe2ab8ee5e430d,1,MTSLSSDDSIDGWWKMPVEEFDVVVAGGGPAGSTVATLVAMQGHRVLLLEKETFPRYQIGESLLPSTVHGVCRMLGVSDELAAAGFPVKRGGTFRWGARPEPWTFSFAVSPLMNGPTSFAYQVERARFDEILLRNAQRKGVDVREGCSVTGVIEGDERITGVRYTDPDGGEHEVSARFVVDASGNKSRLYSQVGGVRNYSEFFRSLALFGYFENGKRLPEPYSGNILSVAFDSGWFWYIPLSDTMTSVGAVVRREMAEKIQGDREKALQALIAECPLISDYLADARRITTGRYGELRVRKDYSYHQTSYWRPGMILVGDAACFVDPVFSSGVHLATYSALLAARSINSVLAEDLDEKTALSEFEARYRREYGVFYEFLVSFYQMNVNEESYFWQAKKVTNNKHTEIESFVELIGGVSSGEAALATAGRIAERSAEFAAAVDQMAASADGNMVPMYKSEVVKQVMQEGGQVQMKAVLGADAEPELPLFPGGLVVSPDGMKWLPYRPA,N[C@@H](Cc1ccc(O)cc1)C(=O)S,N[C@@H](Cc1ccc(O)cc1)C(=O)S,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-2564f21bc22c36871d6d,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFSLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSSYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,CC1NCCc2c1[nH]c1ccccc21,CC1NCCc2c1[nH]c1ccccc21,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-e8dedb66d09f7dc99e0b,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIVLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-a0bd500821a86e562ff1,1,MNVEQIDENLAKFLAERYTPESVAQLADRFHRFGFVKFDAANRLVPDELQTAVREECDLLIEQHKERRNLLLSTTGNTPRRMSVVKSEEIEKSELISTLSRSEVLLGFLAGITREEIIPEVSSDERYLITHQEFKSDTHGWHWGDYSFALVWALRMPPIEHGGMLQAVPHTHWDKSNPRINQTLCEREINTHGLESGDLYLLRTDTTLHRTVPLSEDSTRTILNMTWAAKRDLEKDLVGNDRWWENPEAEAARAVDNA,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D2:1]-[C;D2+:2]-[C;D2:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D2:3]
aries-halogenase-07aa2015d482734372d4,1,MKIESVAIVGGGSSGWMTAAALSKLCPQLEIALIEDPNIKTVGVGESTLGHFNKFLHLLDLKDEDWMPACNATYKNSIRFTNFREGKGEVFEYPFGPSLDVSFFSQTDGINTWGKLANKYPEDFPPETFARFVNSNTYLAEHNRLTRNKDNKIPNFNFDWDTAYHIDAELFGQYLKEKIALPNGVKHIQGKVTGYQKESPNNHNFKYIILDQETAIFADLYIDCTGFKSLLLGEFMGEAFSPFSKKLANDKAMATRIPYENREEEMHNVTDCHAMKNGWVWNIPLWNRIGTGYCYSSRFVSKDDAEAEFREHLGERGKDAKIFHIDIGHGKRTRAWVNNCVGIGLSYGFIEPLESTGLLTTHENIENLVYLINQRDGYVTQAERDGFNYTCDHQIDSFSDFVAMHYAYSMRTDTPYWKWCTQMCNYMPESMGPHRQKQSTWQDLSTDTIGLNTWHINHNGISFIIAGHGLRPQSYDKLSEVLLKRNNESDYYYEDIRKDWLKHYESMVEYVKTLPTHYEFLRDEIYGSAE,Oc1ccc2ncccc2c1,Oc1ccc2ncccc2c1,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-74bb05d20f937f744cbf,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVATNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-04e97796ac4d1ffe8513,1,MKHQPCVITLMTDFGDQDAYVGIMKGVITEVNPRANIIDICHSIPPQDIFKGAYLLYTSYKYFPKGTIHVAVVDPGVGSKRNIVCVETRNYLFLTPDNGILGFIIQEERPKRIIRVTNNNYFLPAPSNTFHGRDVFAPVAAHLSLGIKPKQLGNATKQLEHLSIPQPVCKNTRQLEGQIISIDRFGNLVTNITKSHLEEYVREQIRDLDRKSGVRSQKPKIRNQTPDEPGKSSKKKMLLPYNTLETTIGKKEITGIVKTYTDVKTGKPLILFGSAGFLEISVNQGNAQKYFTVDKGNRILISWMHGTSSKRTDIRHNTIETGTKRHR,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,[C;D1+:1]-[C;D2+:2]-[S;+;D3:3]>>[C;D1+:1]-[C;D2+:2]-[Cl;D1:4]
aries-halogenase-100e667d1f4c2509d4c8,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,C[C@H]1CCCCCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,C[C@H]1CCCCCC(=O)Cc2cc(O)cc(O)c2C(=O)O1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-f59f52637e1f7462419d,1,MDEIDDPRIRSVVIVGGGTAGWMTAAALVQHFRTAPLKITVVESSDIGTIGVGEATIPTIRRFYGQLGLRDDDVMRATQATCKLGIRFLDWSGPGSDFIHPFGLYGQDVKGIGFHHYWLKQRRAGDAAPLAAYSLGAALAAGGKFTLPSPHPPSQLSVFDWALHLDAGLFAQHLRAYAEAGGCARIDARIRSVELRPEDGFVRALTLDDGREVEGDLFVDCSGFKGLVIGEALGVGFEDWGRWLPCDAAYAVQSENRPGDAPAPFTRVTARSAGWQWGIPLRHRAGNGLVFSSAHLSDDQALAELMPHLLGDPLTEPRRIPFRPGRRSQAWAKNCVAIGLSSGFLEPLESTSIALIETGIERLKALFPDRRFAQPILDEFNDQTAREMERVRDFIILHYKLNRRTDTDFWRDCREMPVPETLERKIALWTARGQFVRYRWEMFHPASWLAIYDGFGLYPDHHDPAVDAMDPAYLARSLAEMRANIADLVARTPEHAQFLAGLDPAASAA,Cc1c[nH]c2ccccc12,Cc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-f6e5ff547d5a47ff234d,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATMPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPFGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-c29ee91a4bd5ffbe6e83,1,MINSVLIVGGGTAGWMTAAYLSKAFDKNINITVVESKEVKKIGVGEATFSTVRHYFDYLGLNESEWLPECSGSYKLGIRFENWDGQGNHFYHPFERWEVVKGFPISEWWLSKKLKDQRFDYDTFLTPHLCEAKRSPRRLDGSLFAQSIDKSLGQSTLAEQRAQYPYAYHFDADGVASFLKRYAMNRGVKHIEDDVTHVEIDTNGNIGYLEAKIYGKLRADLYIDCTGFKGLLINKALNEPFISFSDVLKNNRAVALRVPRENENDIEPYTTARTMSNGWRWTIPLYKRNGYGYVYCNKYQSPEEAEMELRKSIPYENAECVANHIRMRIGRSNRSWVKNCVAIGLSSAFVEPLESTGIFFIQHGIEQLVRFFPRSSGNELLIEEYNTRVNRVVDGVKEFLLLHFSLAQRNDTLYWKEWKNVELPKELLKKITLAQDHLLDKETIYPFYHGFEEYSWNTMILGLCSGSLNNKPALSLMTSDEADEMLLQHYMKAENMVNNLPTCYEYLKHIHDLKNKN,N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O,N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-e40aa9d56ec908c9d868,1,MNKPIKNIVIVGGGTAGWMAASYLVRALQQQANITLIESAAIPRIGVGEATIPSLQKVFFDFLGIPEREWMPQVNGAFKAAIKFVNWRKSPDPSRDDHFYHLFGNVPNCDGVPLTHYWLRKREQGFQQPMEYACYPQPGALDGKLAPCLSDGTRQMSHAWHFDAHLVADFLKRWAVERGVNRVVDEVVDVRLNNRGYISNLLTKEGRTLEADLFIDCSGMRGLLINQALKEPFIDMSDYLLCDSAVASAVPNDDARDGVEPYTSSIAMNSGWTWKIPMLGRFGSGYVFSSHFTSRDQATADFLKLWGLSDNQPLNQIKFRVGRNKRAWVNNCVSIGLSSCFLEPLESTGIYFIYAALYQLVKHFPDTSFDPRLSDAFNAEIVHMFDDCRDFVQAHYFTTSRDDTPFWLANRHDLRLSDAIKEKVQRYKAGLPLTTTSFDDSTYYETFDYEFKNFWLNGNYYCIFAGLGMLPDRSLPLLQHRPESIEKAEAMFASIRREAERLRTSLPTNYDYLRSLRDGDAGLSRGQRGPKLAAQESL,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-50f33355a7ee09448ecd,1,MSDNSTDVVVIGGGPAGALSAYQLAKQGHSVVLLEREEFPRFHIGESLLPYMMGLFDRIGIREAVETKGYVPKFGGEFIDPNEEKFFSDVFRADFSKQGDGRYDRAFQVERAKFDGMLVEEAGKAGAEVHLGATVGELLMEGDRMVGVRYTKDGQEHEVRSRYVVDASGRAGRVAHKFGLRERLEKLRMVAVFRHYEGLDEKHNLGVEGDIQVGAHADGWVWAIPLSKDVISVGTVMPRDVFRASTPEEVFEEHKARIPRIVARLTDTRPTMDLKVETDYCYHSDTVTGPGWVMVGDAGCFGDPMFSGGVLVASATAVRAAETLSDALNNPEDADRLIDEYANFFKTGYDTYIRLIHAFYDGELVAVAADAGRTTDRETLERYLIRLIGGDFWSEHNAVAQEMRRRTEWDTFSPFQRVFGCPSYPHLDEQDRKERAESRVRRVTQGQ,C/C1=C\C[C@H](O)/C=C/[C@H](C)[C@@H](O)[C@H](C)/C=C(\C)C(=O)c2c(O)c(C)cc3c2C(=O)C=C(NC(=O)\C(C)=C/C=C\C=C\[C@@H](C)[C@@H](O)CC1=O)C3=O,C/C1=C\C[C@H](O)/C=C/[C@H](C)[C@@H](O)[C@H](C)/C=C(\C)C(=O)c2c(O)c(C)cc3c2C(=O)C=C(NC(=O)\C(C)=C/C=C\C=C\[C@@H](C)[C@@H](O)CC1=O)C3=O,[C;D1+:1]=[C;D3:2]>>[C;D2+:1](-[Cl;D1:3])=[C;D3:2]
aries-halogenase-1ee4e10c0c7e1bd5ff9c,1,MTQKSPANEHDSNHFDVIILGSGMSGTQMGAILAKQQFRVLIIEESSHPRFTIGESSIPETSLMNRIIADRYGIPELDHITSFYSTQRYVASSTGIKRNFGFVFHKPGQEHDPKEFTQCVIPELPWGPESHYYRQDVDAYLLQAAIKYGCKVHQKTTVTEYHADKDGVAVTTAQGERFTGRYMIDCGGPRAPLATKFKLREEPCRFKTHSRSLYTHMLGVKPFDDIFKVKGQRWRWHEGTLHHMFEGGWLWVIPFNNHPRSTNNLVSVGLQLDPRVYPKTDISAQQEFDEFLARFPSIGAQFRDAVPVRDWVKTDRLQFSSNACVGDRYCLMLHANGFIDPLFSRGLENTAVTIHALAARLIKALRDDDFSPERFEYIERLQQKLLDHNDDFVSCCYTAFSDFRLWDAFHRLWAVGTILGQFRLVQAHARFRASRNEGDLDHLDNDPPYLGYLCADMEEYYQLFNDAKAEVEAVSAGRKPADEAAARIHALIDERDFAKPMFGFGYCITGDKPQLNNSKYSLLPAMRLMYWTQTRAPAEVKKYFDYNPMFALLKAYITTRIGLALKK,Nc1c(Cl)cccc1-c1cc[nH]c1,Nc1c(Cl)cccc1-c1cc[nH]c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-a7631504c6cdcec67bd3,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,CC(C)NCC(O)COc1cccc2[nH]c3ccccc3c12,CC(C)NCC(O)COc1cccc2[nH]c3ccccc3c12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-2120ea176dd154dd5382,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVWTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,Nc1ncnc2c1ncn2[C@@H]1O[C@H](C[S@+](CC[C@H](N)C(=O)O)Cc2ccccc2)C(O)[C@@H]1O,Nc1ncnc2c1ncn2[C@@H]1O[C@H](C[S@+](CC[C@H](N)C(=O)O)Cc2ccccc2)C(O)[C@@H]1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-45c7b309a477a1b496fd,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVWTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-e1fee01ee26d26469e25,1,MNNPDALRKVCIVGGGTAGWIAAAVMAHHMKGRLFEIELVESDDIGTIGVGESTIPPFMELIAKLDIDEQDFVRQVQASFKLGIEFKDWFRKDESYFHPFGDVGQRVELSDFYQCWRKATLAGHDFPLQDFAPATVMAHAGRFMLPFKARNTPIAGASYALHVDAKRVAQFLRGHAEARGVKRTEGIVTDVALDARGFVSTLTLKDGRTIDADFFIDCSGFRALLIEKALGSGYTDWSNYLFCDRAIAAQTENVGPPRPYTLAEAQDAGWRWRIPLQHRTGNGHVYSSEFMSDEEATRILLEKVEGEVVAGPMVVPFRTGVREKIWHRNVLAIGLSSGFIEPLESTAIHLIYRGMDFFFRFLPDRHCDPALADEYNRRMVADYTEIRDFIVLHYCTTARDDTPFWRKCRDMDWPDSLKERVELFRSNGTLREGLDELFRSVSWFSVLEGMGIRPRTYHPLVDRIDEAMLYAGLDKAREQLAGFVRQLPTQQQFIDAHCRAEKVDLTRPVMAGV,c1cnc2[nH]ccc2c1,c1cnc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-884787790b634bcde4b9,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNPWSNGSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-c24703aeed68217acf95,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKTPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-a5a2b61e6d380d20d611,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Cc1ccccc1NC1CCNCC1,Cc1ccccc1NC1CCNCC1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-b553e6af4fb183a84375,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVFTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-1d234b0fe9253354bebf,1,MKKTLATLFLLTCLGSSSAYADNALILQTDFSLKDGAVSAMKGVAFGVDHNLKIFDLTHEIPPYNIWEGAYRLYQTASYWPQGSVFVSVVDPGVGTDRKSVVLKTKNGQYFVSPDNGTLTLVAESLGIESVRQIDEKTNRLKGSEKSYTFHGRDVYAYTGARLASGAITFEQVGPELPAKVVELSYQKAKATKGEVKGNIPILDIQYGNVWSNISDELLNQAGIKLNDTLCVTISEGSQQKYAGKMPYVASFGDVPEGQPMVYLNSLLNVSVALNMDNFAQKHQVASGADWNIDVKKCAK,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,[C;D1+:1]-[C;D2+:2]-[S;+;D3:3]>>[C;D1+:1]-[C;D2+:2]-[Cl;D1:4]
aries-halogenase-1070a982af22fe711ec5,1,MTTSGHTSFSDYSPRRRSMLLGGLGGAAALSAAGFTGMASASPRGSAGSKAAAIEFDLDKDNYIKWAQPTDENAGQSPTLAILGPMDVTVFLWINRVVWLAAFDALAPYHETAVGVYSQIPRRPSSESATNRNLNIAALHAQHGVWKRVLPQQVDQLRELMTALGLDPSDETENLSSPVGIGNVAAKNAFNALKNDGMNFLGYEGRKYNPRPWADYTGYEPVNTAFKVNNPSRWQPQLQAHNARRAGGGPGDLGIYVTQHFVTPQTARTKAHIFRDPSRFRIPRPEFSDHTNTRAYKRSVDEIIDASANLNDERKALAEIMENKLWGIGHSSIVIANKYDQNNEMGVHGWCHWMLAHVLATFEPLIAAWHHKTRFDAVRPVTAIRHVYGNRKIRAWGGVGMGTVDIRASEWSSYLPVGDHPEYPSGSTSLCSATSQAARRYFDSDELDWTINYPAGSTVVEPGITPGKDLSIHIPTWTDFTRTCATSRVWGGVHFQTTVDRTIDFGEQFGDLAHEFVQRHVKGDVKD,CC(C)=CCC/C(C)=C/Cc1c(O)cc(O)c2c(O)cc(O)cc12,CC(C)=CCC/C(C)=C/Cc1c(O)cc(O)c2c(O)cc(O)cc12,[C;D2:1]-[c;D3:2]1:[c;D3:3](-[O;D1:4]):[c;D2:5]:[c;D3:6](-[O;D1+:7]):[c;D3:8]:[c;D3:9]:1>>[C;D2:1]-[C@@;D4:2]1(-[O;D1:10])-[C;D3:3](-[O;D1:4])=[C;D3:5](-[Cl;D1:11])-[C;D3:6](=[O;D1+:7])-[c;D3:8]:[c;D3:9]-1
aries-halogenase-18167da210996cf3525e,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIFLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-94f136bbfce57e5c6f1c,1,MEMTDFSLTKQELQQFDRDGFIGPFTLYEPEEMKQMHKTIRAQLFNRTHAPYDAPLDVAITNYDRHLDVDLLTSHVFRKEIVHRVRSILGPDVICWRSEFIPKYPGNEGTDWHQADTFAHASGEPQLVWPEGEPFGGAINVWTGFTDATQENGCMQFIPGSHKQMNYDETRGMTFDPVTNNNVVKGQYPRGFNGYDYTTLQKDKSWKPDEASAVPIVMKAGQFVIFRSMLMHSSLPNSTPDKTRLGYVARYVPGRVKVYPDTDYVKEFGGEYRLDRFGVVQVSGTTTDPKNRVARKSLSGMDLKPLVIY,CC[C@@H](C)C(N)C(=O)S,CC[C@@H](C)C(N)C(=O)S,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-dafff407d7450f62b0dd,1,MSNNTVSTKPALHFLDINATEVKKYPTAIQDIIINRSFDGMIIRGVFPRDTMEQVARCLEEGNDGGMKSILNKNEEFGTKVAQIYGHAIVGQSPDLKDYFASSAIFRQACRTMFQGSPDFEEQVESIFHSLSELPVEIPTGPEGQTYTPATIRLLLEGREIAVHVGNDFLLMPAANHLKTLLDLSDQLSYFIPLTVPEAGGELVVYSLEWNPQEASKYAQMQEYMDDVESKIKSNQSQSVAYAPGPGDMLLFNGGRYYHRVSEVIGNSPRRTIGGFLAFSKQRDKIYYWS,C=C[C@@]1(C)CC[C@@H]2C(C)(C)c3cccc4[nH]c5c(c34)[C@@]2(O)[C@]1(C#N)C=CC5(C)C,C=C[C@@]1(C)CC[C@@H]2C(C)(C)c3cccc4[nH]c5c(c34)[C@@]2(O)[C@]1(C#N)C=CC5(C)C,[C;D2:1]-[C;D2+:2]-[C;D4:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D4:3]
aries-halogenase-447512622f9767785e7d,1,MDEIDDPRIRSVVIVGGGTAGWMTAAALVQHFRTAPLKITVVESSDIGTIGVGEATIPTIRRFYGQLGLRDDDVMRATQATCKLGIRFLDWSGPGSDFIHPFGLYGQDVKGIGFHHYWLKQRRAGDAAPLAAYSLGAALAAGGKFTLPSPHPPSQLSVFDWALHLDAGLFAQHLRAYAEAGGCARIDARIRSVELRPEDGFVRALTLDDGREVEGDLFVDCSGFKGLVIGEALGVGFEDWGRWLPCDAAYAVQSENRPGDAPAPFTRVTARSAGWQWGIPLRHRAGNGLVFSSAHLSDDQALAELMPHLLGDPLTEPRRIPFRPGRRSQAWAKNCVAIGLSSGFLEPLESTSIALIETGIERLKALFPDRRFAQPILDEFNDQTAREMERVRDFIILHYKLNRRTDTDFWRDCREMPVPETLERKIALWTARGQFVRYRWEMFHPASWLAIYDGFGLYPDHHDPAVDAMDPAYLARSLAEMRANIADLVARTPEHAQFLAGLDPAASAA,c1ccc2[nH]ccc2c1,c1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-c56b05eb525718f02df5,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACADAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKTPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-3f735c67d29014733cf5,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMVINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,C=CC(C)(C)c1[nH]c2ccccc2c1CCNC,C=CC(C)(C)c1[nH]c2ccccc2c1CCNC,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-ed5667b58b1a81344b92,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFVADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACADAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKDPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-c344fdf40e328b7856fd,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYRGNFEEEFRNPWSNGSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-d15eff82084cddbc1b35,1,MGIPADNLQNRAKASFDTRVSAAELALARGVVPSFANGEELLYRNPDPENGDPSFIASFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIADLTLGPARDPDTGLPIWRSDLANSLELEVRGWANSSAGLTFDLEGPDAQSIAMPPAPVLTSPELVAEIAELYLMALGREIEFSEFDSPKNAEYIQFAIDQLNGLEWFNTPAKLGDPPAEIRRRRGEVTVGNLFRGILPGSEVGPYLSQYIIVGSKQIGSATVGSKTLVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLYVQDAADFRGFESYEPGARLIRTIRDLATWVHFDALYEAYLNACLILLANRVPFDPNIPFQQEDKLDNQDVFVNFGDAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKIAAEKGESIFPEVDLAVEELGDILEKAEISNRKQNIADGDPDPDPSFLLPMAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDSNFQIDQVFEVDKDEDKLVKSSFKGTLTVAGELNKLADNIATGRNMAGVRYFSDQFESLLLGEQVAIGILEEQSLTYGENFFFNLPKFDGTTIQI,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-4dfbe272201d319815b0,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Oc1ccccc1,Oc1ccccc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-a1dc2a3800abc8019d31,1,MSPSFVILGGGTAGWITAHLLERAWPDATITVVESPEIGTIGVGEGSTPSLKRFFEIIGAAEADWMPRCGATYKAGIRFVDWSPAAPWRDYRHPFTTQIDVHTEDAFILNCRNRRLGHDVPVRPDDFLLNGVLSAKGLAPVAPPNFPFRIEYGYHFDAGLLGQYLRELAVTRGVVHRPATVTTVRRAENGDIAALVTDREETIAGDIFVDCSGFNGLLIERTLGVPFHSFKDNLFNDAAVVVPTEMTGRPPVETVATALSNGWCWSIPLRHRVGNGYVYARDCQSPDAAETELRRTLGVSDAVPARHLTFRVGQVARHWERNCVAVGLSQGFIEPLEATALHLVLGTVEQFIRHYRDGGCTDRHRAAFNTVAAERMDGVRDYIVAHYKLNTRTDTDYWRANAANEALSDPLLHILDRWFRRGDIAEELARQGQRSHFGTLSWHCLLAGYGAFPPVSEARRDDMDFYAARRVGAFLEGCSRNFAPA,O=C1C[C@@H](c2ccc(O)cc2)Oc2cc(O)cc(O)c21,O=C1C[C@@H](c2ccc(O)cc2)Oc2cc(O)cc(O)c21,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-9d45a4710a9abc4e87ca,1,MHAPAPSESQRLVRRVVIAGGGTAGWMAAAALSKLLGRQLQITLVESDEIGTVGVGEATIPSLVTFHRLLEIDEAQFMAATQATFKVGIAFEHWRDVDRHYIHSFGHTGTDHWSAGFQHFWLKAHARGVARDFGDYCLELRAAQEGRFAHLPNGGMNYAYHLDAGLYARFLRRFSEGFGVQRIEGRIGSVQTDAHSGDIAALVLDDGTRIEGDLFLDCTGFRALLIGQTLGVGSEDWSRWLFADSALAVQTESVGAPVTFTRARADRAGWMWRIPLQHRVGNGIVYSSRYTDQDSAAQVLEHNLQGRALTTPRALRFTPNQRHRVWEKNCVALGLASGFLEPIESTNIHLIQRGIVRLLQTFPQVIDPVDIAEYNRQAAEEIAHIRDFVILHYHATDRRDTAFWRDCASMEIPDSLRHRMELFRQSGRVFHQGNELFAENSWIQVMLGQGIVPRHHHPVADLMGDAELSQFLEGIRQRVEATLARLPPHAEFLRRYCPAPAPPAPMPQPAPGTPLAAPAA,Oc1ccc2[nH]ccc2c1,Oc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-c3cef2b615f9980e2143,1,MLCHAADTTRGSPMPDTGVLRLLTSEQRAKGWRRQLEGEKSLGFHPSETPYIKYLEGSETWKKVKLPTDGISASKILGKIMARVRIATALAVVLAAPCLAFDEVTASGVFPEEHKHTGEGRHLQTCTNSDDALDPTAPNRRDNVAFASRRDAARRERDGTGTVCQITNGETDLATMFHKSLPHDELGQVTADDFAILEDCILNGDFSICEDVPAGDPAGRLVNPTAAFAIDISGPAFSATTIPPVPTLSSPELAAQLAELYWMALARDVPFMQYGTDEITTTAAANLAGMGGFPNLDAVSIGSDGTVDPFSQLFRATFVGVETGPFVSQLLVNSFTIDAITVEPKQETFAPDLNYMVDFDEWLNIQNGGPPAGPEELDEELRFIRNARDLARVSFVDNINTEAYRGSLILLELGAFSRPGINGPFIDSDRQAGFVNFGTSHYFRLIGAAELAQRASCYQKWQVHRFARPEALGGTLHNTIAGDLDADFDISLLENDELLKRVAEINAAQNPNNEVTYLLPQAIQVGSPTHPSYPSGHATQNGAFATVLKALIGLDRGGECFPNPVFPSDDGLELINFEGACLTYEGEINKLAVNVAFGRQMLGIHYRFDGIQGLLLGETITVRTLHQELMTFAEEATFEFRLFTGEVIKLFQDGTFSIDGDMCSGLVYTGVADCQA,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-9dfbae98257df8db309d,1,MEAQVPLSTDILVIGGGPAGSYAAAVLAREGFKVVLLEKDVFPRYHIGESMLPSCRPFLRFIDFEEKMKNYGFFPKPGAALKLNQDKREGYTDFTANGPDNAAWNVVRSEFDDLLLRHAAELGVHVYEGVQVEKIHFSPDESTRPVSLAWSKGDGTQGDVSFNWLVDASGRNGIMSTRYLKNRTFNKSLKNVAVWGYWTGAGRYAPGTKRENAPWFEALTDETGWAWFIPLHNGATSVGVVLAEDESKRKKAQHRAESNGKSLSEVQHDCYMADLQRAPGLIQLLGSEAKFEGKLMSAGDYSYHASEYAGSHFRIAGDAGAFIDPFFSSGIHLALTGGLSAASTIAASIRGNCTEEEACAFHSSKVETAYTRFLFVVLGIYKQIRAQETAVLYEAEEDNFDRAIDSLRPVIQGCADADENLTEAELQSTLDFCRSVLAPNQQQNNLRTPVDTGAADVKAKHAPSETDAQNPLQSMDDCKRNFGTEVINGFYVKMEQGMLGLVCA,Cc1cc(O)cc(O)c1C(=O)O[C@@H]1C[C@]2(C)[C@H]3CC(C)(C)C[C@H]3C=C(CO)[C@]12O,Cc1cc(O)cc(O)c1C(=O)O[C@@H]1C[C@]2(C)[C@H]3CC(C)(C)C[C@H]3C=C(CO)[C@]12O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-bb08e6dbeccef5f7e04c,1,MDKPIIAYLSDIGNHDEAHALGKGLIKTIAPGAEIVDITHQVTPFDVREGGLYLQDVPASFPANTVIAAYVYPETGTSTRTVVVRNEKGQLLVAPNNGLLTWALKAVPAVEAWEVTSPDVMNQPVTPTWYGKDVVVACGAHLAAGVAPSAVGPKIDVAKLVTLPTTPAVQLGDGSVRGEVVRIDKAFGNVWTNISLDALSGGGALDGKTLQVTAEGLSVEIPYYATFGEVPIGEPLVYNNSRGKVALGLNQGSFLERYGVAAGDTVTIGLV,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,[C;D1+:1]-[C;D2+:2]-[S;+;D3:3]>>[C;D1+:1]-[C;D2+:2]-[Cl;D1:4]
aries-halogenase-3a3a99897cabe3d52773,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVWTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,[C;D1+:1]-[C;D2+:2]-[S;+;D3:3]>>[C;D1+:1]-[C;D2+:2]-[Cl;D1:4]
aries-halogenase-dbaf899fbd964344fefd,1,MNTLNDTISSYSNAAFTAKKIRKLREEFSRHGIVKIPDIVSEQLKQNIHNEIYGLLENYAERRDLLLKTTDNTPRYLSVVRSELIEEQSKMIREVRESDALLQFLEKITQEKLLTHVKEDEKFVITKQEFSGDTHGWHWGDYSFALIWIVEMPPVDCGGMLQCVPHTSWDKEAPDLYQYFCDNPIYTHSFVPGDVYLLKADTTLHRTVPLRYDATRIMLNMTWGSIRDQDNPFLSVDDRWWDNLNAQAALHVHN,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D0+:1]>>[C;D2+:1](-[Cl;D1:2])-[Cl;D1:3]
aries-halogenase-154d72ced7915c97e732,1,MINSVLIVGGGTAGWMTAAYLSKAFDKNINITVVESKEVKKIGVGEATFSTVRHYFDYLGLNESEWLPECSGSYKLGIRFENWDGQGNHFYHPFERWEVVKGFPISEWWLSKKLKDQRFDYDTFLTPHLCEAKRSPRRLDGSLFAQSIDKSLGQSTLAEQRAQYPYAYHFDADGVASFLKRYAMNRGVKHIEDDVTHVEIDTNGNIGYLEAKIYGKLRADLYIDCTGFKGLLINKALNEPFISFSDVLKNNRAVALRVPRENENDIEPYTTARTMSNGWRWTIPLYKRNGYGYVYCNKYQSPEEAEMELRKSIPYENAECVANHIRMRIGRSNRSWVKNCVAIGLSSAFVEPLESTGIFFIQHGIEQLVRFFPRSSGNELLIEEYNTRVNRVVDGVKEFLLLHFSLAQRNDTLYWKEWKNVELPKELLKKITLAQDHLLDKETIYPFYHGFEEYSWNTMILGLCSGSLNNKPALSLMTSDEADEMLLQHYMKAENMVNNLPTCYEYLKHIHDLKNKN,N[C@@H](Cc1c[nH]c2c(Cl)cccc12)C(=O)O,N[C@@H](Cc1c[nH]c2c(Cl)cccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-b11b916a54e9e274f044,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPNKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-3581b125128cab6e3253,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMVINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Oc1ccccc1,Oc1ccccc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-f652f5c87c84f33899f9,1,MKIESVAIVGGGSSGWMTAAALSKLCPQLEIALIEDPNIKTVGVGESTLGHFNKFLHLLDLKDEDWMPACNATYKNSIRFTNFREGKGEVFEYPFGPSLDVSFFSQTDGINTWGKLANKYPEDFPPETFARFVNSNTYLAEHNRLTRNKDNKIPNFNFDWDTAYHIDAELFGQYLKEKIALPNGVKHIQGKVTGYQKESPNNHNFKYIILDQETAIFADLYIDCTGFKSLLLGEFMGEAFSPFSKKLANDKAMATRIPYENREEEMHNVTDCHAMKNGWVWNIPLWNRIGTGYCYSSRFVSKDDAEAEFREHLGERGKDAKIFHIDIGHGKRTRAWVNNCVGIGLSYGFIEPLESTGLLTTHENIENLVYLINQRDGYVTQAERDGFNYTCDHQIDSFSDFVAMHYAYSMRTDTPYWKWCTQMCNYMPESMGPHRQKQSTWQDLSTDTIGLNTWHINHNGISFIIAGHGLRPQSYDKLSEVLLKRNNESDYYYEDIRKDWLKHYESMVEYVKTLPTHYEFLRDEIYGSAE,Cc1cc(N)n(-c2ccccc2)n1,Cc1cc(N)n(-c2ccccc2)n1,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-2fffc4b65cb862bc9ad3,1,MSNNTISTKPALHFLDINATEVKKYPTAIQDIIINRSFDGMIIRGVFPRDTMEQVARCLEEGNDGGMKSILNKNEEFGTKVLQIYGHAIPGQSPDLKDYFASSAIFRQACRTMFQGSPDFEEQVESIFHSLSELPVEIPTGPEGQTYTPATIRLLLEGREIAVHVGNDFLLMPAANHLKTLLDLSDQLSYFIPLTVPEAGGELVVYSLEWNPQEASKYAQMQEYMDDVESKIKSNQSQSVAYAPGPGDMLLFNGGRYYHRVSEVIGNSPRRTIGGFLAFSKQRNKIYYWS,C=C(C)[C@H]1CCC(C)(C)C(=O)[C@@H]1c1c[nH]c2ccccc12,C=C(C)[C@H]1CCC(C)(C)C(=O)[C@@H]1c1c[nH]c2ccccc12,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-d1a08ae1268b2fc1248a,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVWTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,C=CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C=CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-b549a5b406eaace4dd10,1,MDEIDDPRIRSVVIVGGGTAGWMTAAALVQHFRTAPLKITVVESSDIGTIGVGEATIPTIRRFYGQLGLRDDDVMRATQATCKLGIRFLDWSGPGSDFIHPFGLYGQDVKGIGFHHYWLKQRRAGDAAPLAAYSLGAALAAGGKFTLPSPHPPSQLSVFDWALHLDAGLFAQHLRAYAEAGGCARIDARIRSVELRPEDGFVRALTLDDGREVEGDLFVDCSGFKGLVIGEALGVGFEDWGRWLPCDAAYAVQSENRPGDAPAPFTRVTARSAGWQWGIPLRHRAGNGLVFSSAHLSDDQALAELMPHLLGDPLTEPRRIPFRPGRRSQAWAKNCVAIGLSSGFLEPLESTSIALIETGIERLKALFPDRRFAQPILDEFNDQTAREMERVRDFIILHYKLNRRTDTDFWRDCREMPVPETLERKIALWTARGQFVRYRWEMFHPASWLAIYDGFGLYPDHHDPAVDAMDPAYLARSLAEMRANIADLVARTPEHAQFLAGLDPAASAA,N#Cc1ccc2[nH]ccc2c1,N#Cc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-2e67088920b9fb6f999e,1,MGIPADNLQSRAKASFDTRVSAAELALARGSVPSFANGEELLYRNPDPDNDDPSFIASFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIADLTLGPARDPDTGLPIWRSDLANSLELEVRGWENSSAGLTFDLEGPDAQSIAMPPAPVLTSPELVAEIAELYLMALGREIEFSEFDSPKNAEYIQFAIDQLNGLEWFNTPAKLGDPPAKIRRRRGEVTVGNLFRGILPGSEVGPYLSQYIIVGSKQIGSATVGSKTLVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLDVQDAADFRGFESYEPGARLIRTIRDLATWVHFDALYEAYLNACLILLANRVPFDPNIPFQQEGKLDNQDVFVNFGDAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKIAAEKGESIFPEVDLAVEELGDILEKAEISNRKQNIADGDPDPDPSFLLPMAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDSNFQIDQVFEVDKDEDKLVKSSFKGTLTVAGELNKLADNIAIGRNMAGVHYFSDQFESLLLGEQVAIGILEEQSLTYGENFFFNLPKFDGTTIQI,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-c4b6fe20fadf12a363d8,1,MGIPADNLQSRAKASFDTRVAAAELALARGAVPSFANGEELLYRNSETGDPSFIGSFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIAALTLGPARDPETGLPIWRSDLANSLDLEVRGWENSSAGLTFDLEGPDAQSVAMPPAPVLTSPELIAEMAELYLMALGRDIEFSEFDSPKNAAFIRSAIERLNGLEWFNTPAKLGDPPAEIRRRRGEVTVGNLFRGILPGSEVGPYLSQFIIVGSKQIGSATVGNKTLVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLDVQDAADFRGFESYEPGARLIRTIRDLATWVHFDSLYEAYLNACLILLANGVPFDPNLPFQQEDKLDNQDVFVNFGSAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKNAFLKSESVFPEVDVLVEELSSILDDSASSNEKQNIADGDVSPGKSFLLPMAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDANFQIDQVFEVDTDEDKLVKSSFPGPLTVAGELNKLADNVAIGRNMAGVHYFSDQFESLLLGEQIAIGILEEQSLTYGENFFFNLPKFDGTTIQI,CC(=O)CCC=C(C)CCC=C(C)C,CC(=O)CCC=C(C)CCC=C(C)C,[C;D1+:1]-[C;D2+:2]=[O;D1+:3].[C;D1+:4]=[C;D1+:5].[C;D1+:6]=[C;D1+:7]>>[C;D1+:1]=[C;D2+:2]-[O;D2+:3]-[C;D2+:7]-[C;D2+:6]-[C;D2+:5]-[C;D2+:4]-[Br;D1:8]
aries-halogenase-de50a7572962ea01141a,1,MLLGGIAGASAAALAGLGHSGSAAAEPAGQAGAAAADFDFDTGNFVRDLIATFRPAEDVYGPMDVTVLHRFIHLSTAAWFDALAPYHPTAVGVFSRIRRRPSSESTTNRNKNIAALYANYRVIKGVEPGRGTAFRDLMVTIGLDPDDESENPTSPIGIGNLAGKAVLARTAHDGMNQLGDEGRTYNGRPYEDYTGYRPVNSAYELRNPSRWQPKHGTHNRRLAGNAGDKGIFTVQAFVTPQQSLVRAHTFRDPGGFGLAPPEFSDHTRPRDYKRSVDEILQASAALTDEQKVKAEIFDNKFLGVGISVGAAAQAHGEMDLDDLVHLLFGSTVAIYDSLVAIWHYKAKYDSVRPFSAVRHIYGSRRVTSWGGVGKGTVRDMPGDEWTSYLNVGDHPEYPSGSGGVCAAQAQATRRFFDDDVLDWTFRAPAGSTMVEPGRTPGTDIALHWDTWTEFVRDCAYSRLWGGVHFSKTAERSIPFGEQFGDLAYEFVQRHVRGEVGED,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-6bcc05d40b1752992b71,1,MTTADEFALSDEQLDSFRRDGFLGPLTIYPPDEMAELWKSVQRQALDRTHAAYPEVDAGMGAPNIFNYDRHLDIDLLAEHACHPKIVGAVGSILGRDLLCWRSEFFPKYPGDEGTDWHQSDTFANASGKPQLLWPGESEESFGAGTITVWTAFTDSTRENGCLQLIPGTHNKMNYDETKNMDYDQERINASVKDGVKRGFFGYDYRQLQIDPDWTPDEDDAFSLVMEKGQCVIFWSTLMHASLPNTSTGRDYRMGFATRYVPTAVRVYPDTDHIEEYGGNISLDRWGAMLVSGRDEHGHNKVVDRTLRGTPVGPAAARRP,O=C(S)C1CCCNN1,O=C(S)C1CCCNN1,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-93de0089bfe55e8e2af2,1,MGIPADNLQSRAKASFDTRVSAAELALARGSVPSFANGEELLYRNPDPDNDDPSFIASFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIADLTLGPARDPDTGLPIWRSDLANSLELEVRGWENSSAGLTFDLEGPDAQSIAMPPAPVLTSPELVAEIAELYLMALGREIEFSEFDSPKNAEYIQFAIDQLNGLEWFNTPAKLGDPPAKIRRRRGEVTVGNLFRGILPGSEVGPYLSQYIIVGSKQIGSATVGSKTLVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLDVQDAADFRGFESYEPGARLIRTIRDLATWVHFDALYEAYLNACLILLANRVPFDPNIPFQQEGKLDNQDVFVNFGDAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKIAAEKGESIFPEVDLAVEELGDILEKAEISNRKQNIADGDPDPDPSFLLPMAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDSNFQIDQVFEVDKDEDKLVKSSFKGTLTVAGELNKLADNIAIGRNMAGVHYFSDQFESLLLGEQVAIGILEEQSLTYGENFFFNLPKFDGTTIQI,CC(=O)OCC=C(C)CCC=C(C)C,CC(=O)OCC=C(C)CCC=C(C)C,[C;D1+:1]-[C;D2+:2]=[C;D1+:3].[C;D1+:4]=[C;D1+:5]>>[C;D1+:1]=[C;D2+:2]-[C;D2+:3]-[C;D2+:5]-[C;D2+:4]-[Br;D1:6]
aries-halogenase-322ac9c5f39fcb8a5cf2,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,C[C@H]1C/C=C/[C@@H](O)CCC/C=C/c2cc(O)cc(O)c2C(=O)O1,C[C@H]1C/C=C/[C@@H](O)CCC/C=C/c2cc(O)cc(O)c2C(=O)O1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-23e3ca332c61648a9e8e,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVFTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,CCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-a754049ffb01baaea795,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-64373b8be1b419b256e9,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNFWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-5bac544801aae74006c1,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVFTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-cf46eed0371a59efdb77,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-37d03b4246ba25e6f2a5,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVATNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,Nc1ncnc2c1ncn2[C@@H]1O[C@H](C[S@+](CC[C@H](N)C(=O)O)Cc2ccccc2)C(O)[C@@H]1O,Nc1ncnc2c1ncn2[C@@H]1O[C@H](C[S@+](CC[C@H](N)C(=O)O)Cc2ccccc2)C(O)[C@@H]1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-8835f492a7c86f65d900,1,MNTRRQQAQNIRNNAAELAANRPHPQHINNKEEYEYRRPKKDGNEPSHIANFTKGLPHDEHTGLLLNSADYDQFVLGIQSGDTTDFARTPLGPAELPKVHGCLSKQKIDCDDDHRSGFWKSQIAQGAAGGDGAKLRAWESAGAGLVFDLEGPDAQAVTMPPAPRLESPELTSEIAEVYSQALLRDIHFSQLRDPGLGDQVNACDSCPTQLSIYEAIDILNTVQIEGQNWFSANCCDLTDDEQARQRPLVTRQNIFRGIAPGDDVGPYLSQFLLIGNNALGGGVFGQEAGHIGYGAIRIDQRVRKATPCKDFMTNFETWLDVQNGADLRGLETYVDADPGKCREFPAYRVITTPRDLATYVHYDALYEAYLNACLILLGMGAPFDPGIPFQKPDVEDKQQGFAHFGGPQILTLVCEAATRGLKAVRFQKFNVHRRLRPEALGGLVDRYKHGKGAGDELKPVAALVEALENVGLLSKVVAHNQLQNQNLDRSGDPSSAGDNYFLPMAFPEGSPMHPSYGAGHATVAGACVTMLKAFFDHGWQLNLGMANGKYISYEPNQDGSSLQQVLLDCPLTVEGELNKIAANISIGRDWAGVHYFTDYIESLRLGEKIAIGILEEQKLTYGENFTMTVPLYDGGSIQI,O=S1(=O)OC(c2ccc(O)cc2)(c2ccc(O)cc2)c2ccccc21,O=S1(=O)OC(c2ccc(O)cc2)(c2ccc(O)cc2)c2ccccc21,[c;D2:1]:[c;D3:2]:[c;D2:3].[c;D2:4]:[c;D3:5]:[c;D2:6]>>[Cl;D1:7]-[c;D3:6]:[c;D3:2]:[c;D2:4].[c;D2:1]:[c;D3:5]:[c;D2:3]
aries-halogenase-670a7f467e5e6917dac5,1,MKTVEFLSDLNHLGVTIWMEGDKLRYRSPQGVMTPDLLEQLKEHKEELIVLLREQADNFSSETDYDVAICGGGLAGLTLARQLKLKQPNLSVVVLDKMARPLPEAGFKVGESTVEVGAFYLANTLQLTDYFNNQHLSKLGLRYFFKPQETEFHKRPELGLSEFHAPKSYQIDRGKLENDLRQFNIEAGIDLKENCSVKDIEFAEGLQQQHKIIYTQGSGANQKTHCIKSRWVVDAMGRRRFIQKKLGLAKPNHNNYSAVWFRVEGRFDVSNFVPASEEKWHRRVPNNNRYYSTNHLCGEGYWVWLIPLSTGYTSIGIVARQDIHPLKNYHNYELAFQWLRENEPVLAAHLEGKSPEDFRKMPKYSYSSKQVFSFNRWACVGEAGLFPDPFYSPGSDSIGFGNSLTTQMIELDLKGQLTPERVDDANHFYLTYHDGLAFNIQNSYNCLKNGTAMATKVIWDTLAGWTFGCLMMFNSIFLDPELKMKVQQINAEFFPLSYRIQQLFRDWANQSLGRVSFEFIDYLAIPFVNELRTRNLQSNKTEAEIIEAYRASLKLLEEFAQVIFQIALEDTRPELLPKINEHPWLNAWAISLDASKWETDGLFSPKSEPRNLHSIKKQYLEAINR,O=C(S)C(O)Cc1ccc(O)cc1,O=C(S)C(O)Cc1ccc(O)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-ab4e225c837ae25f01d7,1,MQHTYPAQLMRFGTAARAEHMTIAAAIHALDADEADAIVMDIVPDGERDAWWDDEGFSSSPFTKNAHHAGIVATSVTLGQLQREQGDKLVSKAAEYFGIACRVNDGLRTTRFVRLFSDALDAKPLTIGHDYEVEFLLATRRVYEPFEAPFNFAPHCGDVSYGRDTVNWPLKRSFPRQLGGFLTIQGADNDAGMVMWDNRPESRAALDEMHAEYRETGAIAALERAAKIMLKPQPGQLTLFQSKNLHAIERCTSTRRTMGLFLIHTEDGWRMFD,CC(C)C[C@H](NC(=O)CCC(=O)O)C(=O)O,CC(C)C[C@H](NC(=O)CCC(=O)O)C(=O)O,[C;D3:1]-[C;D2+:2]-[C;D3:3]>>[C;D3:1]-[C@@;D3+:2](-[Br;D1:4])-[C;D3:3]
aries-halogenase-8c93cd35d2c753657eb0,1,MVSKTLDFALTPAELTQFQRDGYIGPFDVYEPEEMEENFRALRPKLINTKTAIYGGKSTVSGVTNLSNYDRHIDVDFLAQHITNPRIVDRVVSALGPDVLCWRTEFFPKYPGDEGTDWHQADNFSNVAGSKHPQIVWPEDAQFGGTITVWTAFTDASIETGALQFIPGSQSQMNYDETKTMDYDPERINAMEKGETRRGFFGYDYRQLQKDPNWRPDESKAVSMVMRKGQSVMFWSTLMHASHPHAGKTDQMRLGYAARYLPPSVSVYPYSTTLDEFGGHASLEKFGNVMVAGANRFHHNKFIDRTLNGYVFPVRETGSPA,CC[C@H](C)[C@H](N)C(=O)S,CC[C@H](C)[C@H](N)C(=O)S,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-08c6f6cb289f84a3beef,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,Nc1ccc([C@@H]2CNC(=O)C2)cc1,Nc1ccc([C@@H]2CNC(=O)C2)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-2f99e0fa3453fe4f6604,1,MIPAPLRNIVIVGGGTAGWMAAAAFARVLGPSFNVQLIESEQLGTIGVGEATVPHIKAFNNLLGIDEAEFVRQTQGSFKLGIEFVDWQRPGTSYIHGFGTQIGHPLGLLPFHQYWIKQQRRGKAQPLGAYTLNTVAATRGKFMTSAGDVPANSPLASIAYAYHFDASQYARFLRGYAEQRGVTRLEGLIEQVQLDAHTGSVQSVQLASGQVVSGDLFIDCSGFRGLLIEEALHTGYHDFTHWLPCDRALAVPCEKVGPPTPYTRSTARAAGWQWRIPLQHRTGNGYVYSSAHISDDEAAAALLANLDGTPLADPRPLRFTTGRRKQFWNRNVVALGLASGFLEPLESTSIHLIQSGISKLLELFPREGISPVLVQRYNDRLAFEFDRIRDFLVLHYHATERDDSAFWRHCRTMPITPELQTTLDLFRDSGRFYRNAEEMFAEISWVQVMVGQGILPQGYHPLVDQVPDTDAEGFLASVAQTISHCVDVMPTHQQFIDRYCRADPVR,c1cnc2[nH]ccc2c1,c1cnc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-f7cf83f3d4f3226fa25a,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,Nc1ccc(Cc2ccncc2)cc1,Nc1ccc(Cc2ccncc2)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-d04babcc634473e9751e,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPSYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-dda106a2f4e910d11cfa,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAILLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-466386c747aaa69ce6d6,1,MSNNTVSTKPALHFLDINATEVKKYPTAIQDIIINRSFDGMIIRGVFPRDTMEQVARCLEEGNDGGMKSILNKNEEFGTKVAQIYGHAIVGQSPDLKDYFASSAIFRQACRTMFQGSPDFEEQVESIFHSLSELPVEIPTGPEGQTYTPATIRLLLEGREIAVHVGNDFLLMPAANHLKTLLDLSDQLSYFIPLTVPEAGGELVVYSLEWNPQEASKYAQMQEYMDDVESKIKSNQSQSVAYAPGPGDMLLFNGGRYYHRVSEVIGNSPRRTIGGFLAFSKQRDKIYYWS,C=C[C@@]1(C)CC[C@@H]2C(C)(C)c3cccc4[nH]c5c(c34)[C@@]2(O)[C@]1(C#N)[C@H]1O[C@H]1C5(C)C,C=C[C@@]1(C)CC[C@@H]2C(C)(C)c3cccc4[nH]c5c(c34)[C@@]2(O)[C@]1(C#N)[C@H]1O[C@H]1C5(C)C,[C;D2:1]-[C;D2+:2]-[C;D4:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D4:3]
aries-halogenase-8c19996aa890257d05d9,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,N#Cc1ccc2ccccc2c1N,N#Cc1ccc2ccccc2c1N,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-0258177156a996996973,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATIPNLQRAFFDYLGIPEEEWMRECNASYKMAIKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESTGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNSNYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-59712c920a3cc7ca6887,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATMPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-084d9897d40c63e437d5,1,MTASYLKAAFGDRIDITLVESGHIGAVGVGEATFSDIRHFFEFLGLKEKDWMPACNATYKLAVRFENWREKGHYFYHPFEQMRSVNGFPLTDWWLKQGPTDRFDKDCFVMASVIDAGLSPRHQDGTLIDQPFDEGADEMQGLTMSEHQGKTQFPYAYQFEAALLAKYLTKYSVERGVKHIVDDVREVSLDDRGWITGVRTGEHGDLTGDLFIDCTGFRGLLLNQALEEPFISYQDTLPNDSAVALQVPMDMERRGILPCTTATAQDAGWIWTIPLTGRVGTGYVYAKDYLSPEEAERTLREFVGPAAADVEANHIRMRIGRSRNSWVKNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKNFPAADWNSMHRDLYNSAVSHVMDGVREFLVLHYVAAKRNDTQYWRDTKTRKIPDSLAERIEKWKVQLPDSETVYPYYHGLPPYSYMCILLGMGGIELKPSPALALADGGAAQREFEQIRNKTQRLTEVLPKAYDYFTQLR,N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O,N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-bedd4ae332286cc06b4b,1,MAIPQKATVLVIGGGPGGSYSASALAREGIDTVVLEADVFPRYHIGESLVASIRPFLKFIDLDDTFVNYGFVRKNGAAFKLNNQKEAYTDFILEAGADTFAWNVVRSESDDLMFKHAAKSGAQTFDGVRVTSIEFTDDDDDDDNNTNRPVSASWKAKDGRTGSIEFDYLVDASGRAGITSTKYLKNRTFNNYLKNVASWGYWEGATPYGMGTPVEGQPFFEALQDGSGWVWFIPLHNNTTSIGIVMNQELSTQKKKLSTTTSSRAFYLESLAGARGISRLLDPTTATLTSDIKHASDWSYNASAYGSPYLRIVGDAGAFIDPYFSSGVHLAVSGGLSAAVSIAASIRGDCPEEAAWKWHSQGVANRYGRFLLVVLGATKQIRAGDRPVLNGVGDEGFDEAFMVIRPVIQGIADVQGKVPVQDVYDAVTFSTNVVQPAAEGKRDPGWVEKARGALSHDEKEVGSVLNNLAKAYKTTDVCEGLMARLERGHLGLKLVSEV,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-7ddc73742388547eecf3,1,MKIESVAIVGGGSSGWMTAAALSKLCPQLEIALIEDPNIKTVGVGESTLGHFNKFLHLLDLKDEDWMPACNATYKNSIRFTNFREGKGEVFEYPFGPSLDVSFFSQTDGINTWGKLANKYPEDFPPETFARFVNSNTYLAEHNRLTRNKDNKIPNFNFDWDTAYHIDAELFGQYLKEKIALPNGVKHIQGKVTGYQKESPNNHNFKYIILDQETAIFADLYIDCTGFKSLLLGEFMGEAFSPFSKKLANDKAMATRIPYENREEEMHNVTDCHAMKNGWVWNIPLWNRIGTGYCYSSRFVSKDDAEAEFREHLGERGKDAKIFHIDIGHGKRTRAWVNNCVGIGLSYGFIEPLESTGLLTTHENIENLVYLINQRDGYVTQAERDGFNYTCDHQIDSFSDFVAMHYAYSMRTDTPYWKWCTQMCNYMPESMGPHRQKQSTWQDLSTDTIGLNTWHINHNGISFIIAGHGLRPQSYDKLSEVLLKRNNESDYYYEDIRKDWLKHYESMVEYVKTLPTHYEFLRDEIYGSAE,CC(C)NCC(O)COc1cccc2[nH]ccc12,CC(C)NCC(O)COc1cccc2[nH]ccc12,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-05550bc685f04599b689,1,MVTQVPSSTNILVIGGGPAGAYAAGVLVREGFEVTLLEKDFFPRYHIGESMLPSWRQFLRFIDMEEKMKNYGFLPKPGGAIKLNQDKREGYTDFIANNPENSAWNVVRSEFDQLLLNHVAEQGVKVYEGTRVDEIHFSPEEPTRPVSLTWSKDDKTRGDISFNWLVDASGRNGLMSTKYLKNRTFNRSLKNVAVWGYWTGTNRYAPGTNRENAPWFEALTDETGWVWFIPLHDGTTNVGVVLVEEDSKRKKAEYRAKHEGKSLAEVQYDRYMEDIQLAPGLIGLLGDGKFDGKLQAAGDYSYHASGYAGPHFRIAGDAGAFIDPFFSSGIHLAFTGGLSAACTIAASIRGHCTEEEASEFHSSKIKTAFTRFLFVVLGIYKQLRAQQSQILYEADEESLDRAILSLRPVIQGAADADADLTKEELENTLDFCKSVLEDEPQANGNGAAKQDAVPAPIPVALSSGAGPEKDAKRREIEAESLRSLQEMDDCKRNFGTEVINGFFVKMEQGVLGLVRA,Cc1cc(O)cc(O)c1C(=O)O[C@@H]1C[C@]2(C)[C@H]3CC(C)(C)C[C@H]3C=C(CO)[C@]12O,Cc1cc(O)cc(O)c1C(=O)O[C@@H]1C[C@]2(C)[C@H]3CC(C)(C)C[C@H]3C=C(CO)[C@]12O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-82af498652ef41247a70,1,MKIESVAIVGGGSSGWMTAAALSKLCPQLEIALIEDPNIKTVGVGESTLGHFNKFLHLLDLKDEDWMPACNATYKNSIRFTNFREGKGEVFEYPFGPSLDVSFFSQTDGINTWGKLANKYPEDFPPETFARFVNSNTYLAEHNRLTRNKDNKIPNFNFDWDTAYHIDAELFGQYLKEKIALPNGVKHIQGKVTGYQKESPNNHNFKYIILDQETAIFADLYIDCTGFKSLLLGEFMGEAFSPFSKKLANDKAMATRIPYENREEEMHNVTDCHAMKNGWVWNIPLWNRIGTGYCYSSRFVSKDDAEAEFREHLGERGKDAKIFHIDIGHGKRTRAWVNNCVGIGLSYGFIEPLESTGLLTTHENIENLVYLINQRDGYVTQAERDGFNYTCDHQIDSFSDFVAMHYAYSMRTDTPYWKWCTQMCNYMPESMGPHRQKQSTWQDLSTDTIGLNTWHINHNGISFIIAGHGLRPQSYDKLSEVLLKRNNESDYYYEDIRKDWLKHYESMVEYVKTLPTHYEFLRDEIYGSAE,O=C1C=C(c2ccccc2)C2(C=Nc3ccccc32)C1,O=C1C=C(c2ccccc2)C2(C=Nc3ccccc32)C1,[C;D1+:1]=[N;D2:2]>>[C;D2+:1](-[I;D1:3])=[N;D2:2]
aries-halogenase-fc9fe956873cfc30c29a,1,MPFITVGQENSTSIDLYYEDHGTGQPVVLIHGFPLSGHSWERQSAALLDAGYRVITYDRRGFGQSSQPTTGYDYDTFAADLNTVLETLDLQDAVLVGFSMGTGEVARYVSSYGTARIAKVAFLASLEPFLLKTDDNPDGAAPQEFFDGIVAAVKADRYAFYTGFFNDFYNLDENLGTRISEEAVRNSWNTAASGGFFAAAAAPTTWYTDFRADIPRIDVPALILHGTGDRTLPIENTARVFHKALPSAEYVEVEGAPHGLLWTHAEEVNTALLAFLAK,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-976d5deeab73696c6413,1,MLTQNQIQHFEEKGWLGPLDIFTSSEVESVKKCIEANSSIKEVEDQPMMMLYNNVLNLNTSRDLHLFHQPIAEMFKNNKIVRVLNQLGGDNLLLWNSNVFCKMPGEGEIKWHQVYDSYDPSAYDPQKPALLYPNNEEIINISVWIALDDATLENGCLHFANGTHKEKFGRIQVPAEEGMFAGIKNHKMVWQGRRKYSIVFDFDDNEWEVEAVPARMGQAIIFTERVMHSSPPNKSKQQRRLGINGRYVPPSVQVYPHRLKGDFIDENFHNIKKHFCILVSGQDDYGINVVRDSHDLDNIELEFQTMSNLVRFGHVQLPKGKKEIELETLYQQAMEGDCLEEEPDPILQPRKYIQWQAWNQLKGMSCSEAMKQYSQIVAKLPVVDQERELPLEEKIKAWLVAYIAKVFNIQPDEVNSTLPFERYALGSAESATLVAELGAWLERDIPATALYSYPTIEFLAKHLANSREAPRCTDRVSVGMTARQ,CCCCCC(=O)S,CCCCCC(=O)S,[C;D2+:1](-[S;D1:2])=[O;D1:3]>>[C;D2+:1](-[C;D1:4])=[O;D1:3] || [C;D1:1]-[C;D2+:2]-[C;D2:3]>>[C;D1:1]-[C@;D3+:2](-[Cl;D1:4])-[C;D2:3]
aries-halogenase-144dc53d5dff011b70e2,1,MNKTIAVIGAGLSGIAAVKQLTDGGHEVTCFEKAESFGGVFADKKIYDDLHLTISNYFMAYSDYVPNHQKLKFWSKKEYINYLGEYIQRFDIAKHIHYDHEVRRVEKQGDKWIVTCKSGGKEHSKEFDMVAVCSGHFQKPKLPDLPGLDMFDGEIEHSNDYRDKHKYTGKRVLCVGLGESSADITSEISEVARKCILSLRRYPAVAPRYMAFQEDPYFTIDTSWLTSRIVNKLPHKYHGGITKGIFNKYVNSRNDHVRIRGEWLKKSGPSHHQAVTKNERLFRPIADGKVMPNIGGIERFEKNSVVFKDGTREEVDAVVFCTGYQLSFPFLDVSISNMRDLFKQMFIPEMGHSLSFIGFVRPQQGGIPVIAEMQCRYLSKLASGEAQLPTLSEMHDVVKHDTKHWQTEYKITPHVASLVNYCHYMDSMAKLVGCMPQIPSLFKDPLLRVKLLHNPQFAAQYRLDGPNNMTHTAREFLLSFPNISSWPRIIHFEVALAAQKLLSRLRLDGLREISK,Oc1cc(O)cc(O)c1,Oc1cc(O)cc(O)c1,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-92a7194ae5db4ecb83f7,1,MDVHEIDETLEKFLAENYTPERVQQLADRFQRTGFVKFDSHMRIVPEELITAVRAEADRLVREHKERRDLVLGTTGGTPRNLSVVKSQDVEQSDLIRAVTRSEVLLTFLAGITRERIIPEVSDDERYLITHQEFASDTHGWHWGDYSFAFIWALRMPPIASGGMVQAVPHTHWDKNAPRINETLCERQIDTYGLVSGDLYLLRSDTTMHRTVPLTEDGAVRTILNVSWSAERDLGKVLTGNDRWWENPEAGAAQPVHRAG,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D2:1]-[C;D2+:2]-[C;D2:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D2:3]
aries-halogenase-2ffb714522d67ca2d1a3,1,MTAAYLKTAFGDRLSITVVESSRIGTIGVGEATFSDIQHFFQFLNLREQDWMPACNATYKLGIRFENWRHVGHHFYQPFEQIRPVYGFPLTDWWLHDAPTDRFDTDCFVMPNLCEAGRSPRHLDGTLADEDFVEEGDELANRTMSEHQGKSQFPYAYHFEAALLAKFLTGYAVDRGVEHVVDDVLDVRLDQRGWIEHVVTAEHGEIHGDLFVDCTGFRGLLLNKALGVPFVSYQDTLPNDSAVALQVPLDMQRRGIVPNTTATAREAGWIWTIPLFGRVGTGYVYAKDYLSPEEAERTLREFVGPAAADVEANHIRMRIGRSQESWRNNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKHFPAADWNPKSRDMYNSAVAHVMDGIREFLVIHYRGAARADNQYWRDTKTRPLPDGLAERIECWQTQLPDTETIYPYYHGLPPYSYMCILMGGGAIRTPASAALALTDQGAAQKEFAAVRDRAAQLRDTLPSHYEYLARMRGLDV,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-5b4202c5f7f05694ef3e,1,MNKPIKNIVIVGGGTAGWMAASYLVRALQQQANITLIESAAIPRIGVGEATIPSLQKVFFDFLGIPEREWMPQVNGAFKAAIKFVNWRKSPDPSRDDHFYHLFGNVPNCDGVPLTHYWLRKREQGFQQPMEYACYPQPGALDGKLAPCLSDGTRQMSHAWHFDAHLVADFLKRWAVERGVNRVVDEVVDVRLNNRGYISNLLTKEGRTLEADLFIDCSGMRGLLINQALKEPFIDMSDYLLCDSAVASAVPNDDARDGVEPYTSSIAMNSGWTWKIPMLGRFGSGYVFSSHFTSRDQATADFLKLWGLSDNQPLNQIKFRVGRNKRAWVNNCVSIGLSSCFLEPLESTGIYFIYAALYQLVKHFPDTSFDPRLSDAFNAEIVHMFDDCRDFVQAHYFTTSRDDTPFWLANRHDLRLSDAIKEKVQRYKAGLPLTTTSFDDSTYYETFDYEFKNFWLNGNYYCIFAGLGMLPDRSLPLLQHRPESIEKAEAMFASIRREAERLRTSLPTNYDYLRSLRDGDAGLSRGQRGPKLAAQESL,CNCCc1c[nH]c2ccccc12,CNCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-29c550b073ecb595e495,1,MKTITAEPRYYLSVEEKQFFQENGYIGPFTLFPPEEMLELWYGIKMDLLDKETAPFPNNKMNYDRHLDIKALNDIISHPKVVDRVSSILGPNVLCWRTEWFPKYPGDEGTDWHQAESFVEFEGESKLVPTESHDGPWELTAWVTFSEATRKNGCMKVMPGTHTTWYFDEHRNIKFEPDNINQKLTKGQKSGFYGYDYDKLKLDPNWEPDESQAVHLEMEPGQFFLFTSRCMHGSEPNTSESSIRYGWSTRFVSTDVRVYPDWDSFEHFGEKFMLDRYSTVLVAGEDTYKHNKVRQPL,CC(C)C[C@H](N)C(=O)S,CC(C)C[C@H](N)C(=O)S,[C;D1:1]-[C;D3+:2](-[C;D2:3])-[C;D1+:4]>>[C;D1:1]-[C@@;D3+:2](-[C;D2:3])-[C;D3+:4](-[Cl;D1:5])-[Cl;D1:6]
aries-halogenase-ceab64951a30f684b7a8,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,CC(=O)NCCc1c[nH]c2ccccc12,CC(=O)NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-c50f690cc8d007104364,1,MAIPQSCTVLVAGGGPGGSYTAAALAREGVDVVLLEADCHPRYHIGESLLPSMRYLLRFIDLEDTFEQHGFQKKLGAFFKLNAKSAGYTDFIRANGPNGYSWNVVRSESDEILFRHATKSGAKTFENVSLKSVNFEPYENDKFTSQDKLTNPGRPVSAEWKTKDGCSGTISFDYLVDATGRVGILSTKYLKNRKFNESFRNIAMWGYFKGNIPPSPGTDRENQPISEGMRDGSGWVWMLPLHNGTVSIGAVVRKDIFQAKKKALPEGTTEAQTLASLVALCPTISSYLEPAELASGIRQAADYSYSANAYAGPNFRIVGDAGCFIDPFFSSGHHLALSSALAAATSINACIRGDCNEFDASRWFAKKVDEGYTLFLVVVMAALKQIRMQEQPILSDLDEEGFDRAFTILRPVIQGAADKETAPKAKGESITETIDLCLTALNDLHDTELQRKLTSIVEAKGTPEQEQLLGKLSPDETAALHRMRAMHSILPMGELEDFENSNIDGFKARLEKGSLGLRRERALCRDHAGDLQM,COc1cc(O)c(C(=O)c2c(C)cc(O)cc2OC)c(O)c1,COc1cc(O)c(C(=O)c2c(C)cc(O)cc2OC)c(O)c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-098ce5419c70dd06d091,1,MTDQRKLTAQRVREDANALAAGRIHPRHQANGDEQRYESANYAMSFTKGLDHNTTTGLIEQSGDFEAFRSAIDNGFAEDFTRHVAVPRAEPRRKWEAPTAGTVYELQGPDPQAVTIPPAPALCSDELTFEMAEVYELALLRDLPFNAFVAGGGSAALADSTARLNSLAYAQDGFNRRPRTTNSSNQLDAQTVFRGSSPGVDQGPYLSQFMLIGNASPSEGITPEQGFINFGAQRIDQRVLEARQQDDYMMKWDDWHRVQQGYEVRADRFDPCKSSGPGQAFTGQRRFIHTPRDLATYVHVDALYQAYLNACLLLLGNGTAFDPGFDLLSGGGEGLLHDPAGGQKVPLNAGGFALWGGPHVLSLVTEVATRGLKAVRYQKFNNHLRLRPEALAARIEKAQEIESRFPTICGCFSEMASDLQQVVDLIRNHNQSLAGEATALLPMAFAEGSPMHPAYGAGHATVAGACVTILKAFFNTSALFVKINDVAGFHSKQHILARLKCGDSVEAGAYQETDCGKRLEFERCGSFHLIEGKYATFKPDGKTNQSCCPLTLEGELNKLAANISIGRNMAGVHYFSDYYDSLRMGEEIAIGILEEQALCYKTDPFVLSVPTFDGDVRRIGQR,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-b85bf0f7330be0793331,1,MDVHEIDETLEKFLAENYTPERVQQLADRFQRTGFVKFDSHMRIVPEELITAVRAEADRLVREHKERRDLVLGTTGGTPRNLSVVKSQDVEQSDLIRAVTRSEVLLTFLAGITRERIIPEVSDDERYLITHQEFASDTHGWHWGDYSFAFIWALRMPPIASGGMVQAVPHTHWDKNAPRINETLCERQIDTYGLVSGDLYLLRSDTTMHRTVPLTEDGAVRTMLVVSWSAERDLGKVLTGNDRWWENPEAGAAQPVHRAG,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D2:1]-[C;D2+:2]-[C;D2:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D2:3]
aries-halogenase-83f317efec40450fbf5f,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,c1ccc2[nH]ccc2c1,c1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-a96fe578bd6bfa165bbc,1,MNNPDALRKVCIVGGGTAGWIAAAVMAHHMKGRLFEIELVESDDIGTIGVGESTIPPFMELIAKLDIDEQDFVRQVQASFKLGIEFKDWFRKDESYFHPFGDVGQRVELSDFYQCWRKATLAGHDFPLQDFAPATVMAHAGRFMLPFKARNTPIAGASYALHVDAKRVAQFLRGHAEARGVKRTEGIVTDVALDARGFVSTLTLKDGRTIDADFFIDCSGFRALLIEKALGSGYTDWSNYLFCDRAIAAQTENVGPPRPYTLAEAQDAGWRWRIPLQHRTGNGHVYSSEFMSDEEATRILLEKVEGEVVAGPMVVPFRTGVREKIWHRNVLAIGLSSGFIEPLESTAIHLIYRGMDFFFRFLPDRHCDPALADEYNRRMVADYTEIRDFIVLHYCTTARDDTPFWRKCRDMDWPDSLKERVELFRSNGTLREGLDELFRSVSWFSVLEGMGIRPRTYHPLVDRIDEAMLYAGLDKAREQLAGFVRQLPTQQQFIDAHCRAEKVDLTRPVMAGV,N#Cc1ccc2[nH]ccc2c1,N#Cc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-59c260251c827eeac4d2,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKDPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-fcd3ea094503446af612,1,MSIPKSCEVLVAGGGPAGSYAASALAREGVDVVLLEADKHPRYHIGESMLPSIRPLLRFIDLEETFEKHGFQKKLGAAFKLTAKREGYTDFVAAHGPNGYSWNVVRSESDELLFKHAAKSGALTFQGVKVDSLEFEPYDSDFPSGGKVANPGRPVAARWSAKDGRSGTISFQYLVDATGRAGITSTKYLKNRKFNEGLKNLAIWGYYKGARPWAEGTPRENQPYFEGMRDGAGWCWTIPLHNGTVSVGAVLRSDLFFAKKKSLGEDVTNAMIMAECMKLCPTIKELLEPAELVSDIKQATDYSYSASAYAGPYFRIVGDAGCFIDPFFSSGHHLAMAGALAAAVSIRASMKGDCSEYEASNWHARKVDEGYTLFLLVVMAALKQIRMQEEPVLSDIDDDGFDRAFQFLKPVIQGSGSAEIVKRFTKKEVSEAIDFAVLALDNMAGAGEHANETNGSNGTGETNGDAKTLENITVEDEKVLSGIRILAKVAPSADMKDLEGTAIDGFMPRLEHGHLGLNRV,O=c1ccc2ccc(O)cc2o1,O=c1ccc2ccc(O)cc2o1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-0ea9ede75763223559ab,1,MEQAAPRVVAFLSDVGTHDEATGLCKGLMSRICPGVTIIDITHQVPAFDVVEGALMLEDVPEFFPEHTVICAYVYPETGSGTPTVAVRNDKGQLLVAPDNGLLTRALDASGVAEARLVTNPAVMNHPPTPTWYGRDVVAACAAHLAAGTPLADVGPVVDDPVRLPDVPFTRHESGLVGRVARIDRAFGNVWTNIPSAALGLPSTPDGPVTLDATVGGERARWPWCTTFSQVATTGRLAYANSRGRLSFALNRGSLVAELGVAPDAPVEVHLPRVPG,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,[C;D1+:1]-[C;D2+:2]-[S;+;D3:3]>>[C;D1+:1]-[C;D2+:2]-[Cl;D1:4]
aries-halogenase-87d8e3aa624e9deb114a,1,MKHGGMASGAIERVVIVGGGTAGWMAAAALGAYLAGAGTRITLIESSEIGTIGVGEATIPTIRRFYAALGMTDAEVMRACEATAKLGIRFVDWKPGTSFVHPFGRFGQDLRGIDFHQYWQKARQAGRAAPLEEYSLGAMLAREGHASVPLPNPPSQLSVFDWALHFDAARFAAHMRAYAERAGVARIDARITDVTLHGETGFIEAVTLDSGERVAGDLFVDCSGFRGLLIGEALGTPYRDWSHWLLCDGAFAVQSERVGEPPSCTTVTARTAGWQWRIPLRSREGNGLVFASDFQGDDEARAELLANIPGAPTMEPRRLRFTPGRREVAWARNCVSLGLASGFLEPLESTSIALIETGIERLKQLFPDKGFDPAVIAEYNAQSAEEMERVRDFILLHYHLSTRDGPFWQACREMTLPDSLAAKLELWRARGAFLRYRWEMFSPASWLAIYGGFEHLPERLDPGVAAVGTDELAQGLEQMRAAIARTVADTPTHSEFLATVDGAAAEPMRTSV,O=[N+]([O-])c1ccc2[nH]ccc2c1,O=[N+]([O-])c1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-617c14bb6cfaff0ae12c,1,MSTRTDSHLDTHNDTRNDTRIQKVVILGGGTAGWMTAAYLGKALQNTVQITVLEAPSIPRIGVGEATIPNLQRAFFDYLGIAEEEWMRECNASYKMAVKFINWRTPGEGSPSPRTVDGHPDTFHHPFGLLPSADHIPLSHYWAAKTLRGETTEPYDHACFVDTAIMDARKAPRWLDSRRATNYAWHFDAQLVADFLRTFAVTKQAVEHVEDEMTEALTDERGYLTALRTKSGRLLDGDLFIDCSGFRGLLINQAMGEPFLDMSDHLLCDSAVATAVPHDDETHGVEPYTSSIAMPAGWTWKIPTLGRFGSGYVFSSRFADRDQATAEFARLWGLDPEQTPFNHIRFRVGRNRRAWVRNCVGIGLASCFVEPLESSGIYFVYAAIHMLAKHFPDRTFDPVLVDRFNREIQDMFDDTRDFLQAHYYFSPRTDTPFWRANKELELADGIKDKAETYRAGLPVNLPISDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGMLPRHPLPSLAHKPESVARAEQLFADIKRKQHEWVRSLPSTHQLLRHLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-76c9d56531b032e8416e,1,MNNPDALRKVCIVGGGTAGWIAAAVMAHHMKGRLFEIELVESDDIGTIGVGESTIPPFMELIAKLDIDEQDFVRQVQASFKLGIEFKDWFRKDESYFHPFGDVGQRVELSDFYQCWRKATLAGHDFPLQDFAPATVMAHAGRFMLPFKARNTPIAGASYALHVDAKRVAQFLRGHAEARGVKRTEGIVTDVALDARGFVSTLTLKDGRTIDADFFIDCSGFRALLIEKALGSGYTDWSNYLFCDRAIAAQTENVGPPRPYTLAEAQDAGWRWRIPLQHRTGNGHVYSSEFMSDEEATRILLEKVEGEVVAGPMVVPFRTGVREKIWHRNVLAIGLSSGFIEPLESTAIHLIYRGMDFFFRFLPDRHCDPALADEYNRRMVADYTEIRDFIVLHYCTTARDDTPFWRKCRDMDWPDSLKERVELFRSNGTLREGLDELFRSVSWFSVLEGMGIRPRTYHPLVDRIDEAMLYAGLDKAREQLAGFVRQLPTQQQFIDAHCRAEKVDLTRPVMAGV,Cc1cc2ccccc2[nH]1,Cc1cc2ccccc2[nH]1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-39e99864636d68f4ab86,1,MIRSVVIVGGGTAGWMTASYLKAAFDDRIDVTLVESGNVRRIGVGEATFSTVRHFFDYLGLDEREWLPRCAGGYKLGIRFENWSEPGEYFYHPFERLRVVDGFNMAEWWLAVGDRRTSFSEACYLTHRLCEAKRAPRMLDGSLFASQVDESLGRSTLAEQRAQFPYAYHFDADEVARYLSEYAIARGVRHVVDDVQHVGQDERGWISGVHTKQHGEISGDLFVDCTGFRGLLINQTLGGRFQSFSDVLPNNRAVALRVPRENDEDMRPYTTATAMSAGWMWTIPLFKRDGNGYVYSDEFISPEEAERELRSTVAPGRDDLEANHIQMRIGRNERTWINNCVAVGLSAAFVEPLESTGIFFIQHAIEQLVKHFPGERWDPVLISAYNERMAHMVDGVKEFLVLHYKGAQREDTPYWKAAKTRAMPDGLARKLELSASHLLDEQTIYPYYHGFETYSWITMNLGLGIVPERPRPALLHMDPAPALAEFERLRREGDELIAALPSCYEYLASIQ,Nc1ccccc1C(=O)O,Nc1ccccc1C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-cfe0815a32292cc38204,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPGFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-a4c42a3f5f7103ddb104,1,MTQARIRKVVIAGGGTAGWVAAAALAHQFRGLLEIVLVESEQIGTIGVGESTVPPIRAFHRFLQIDEQEFLRAVAGTFKLAISFEDWQGQGDRYIHPFGSTGQGTLVCAFHHFWLEAQRRGMHSGFDEYCLEAQAARADRFAVLQQPAVNYAYHLDAGLYARFLRTHAQRYGATRIEGKIQQVRQHADSGFVEALVLEDGQVVEGDLFIDCTGFRGLLIEQTLHTGYEDWSHWLPCDRAVAVQTESVEPPVPYTRAIAHAAGWRWQIPLQHRVGNGLVYARAHLSDDEASAMLLAAVQGTPRRDPMLVPFVTGRRLQTWNKNVVALGLASGFVEPLESTSIHLAIVAVMRLITLFPADGIAQPQVDLFNRISRAEAEHVRDFVILHYHATQREEALWRQCRAMELPESLQLRLRAWREGAHAWQDGDELFRVDSWTHVLLGQRVAPAQHHPLTRALPDQHLQQLLDGIRQPLQHVVTQLPTQQAFIDSYCKVDQSTWG,Cc1ccc2[nH]ccc2c1,Cc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-715da20ae91a97087436,1,MADAMPKVIVIGGGPGGSTAAGLLAKGGVEVKLLERAEFPRYHIGESITTSCRAIIDYVGALEKVNACGFTTKTGVLMRWGQEKDWVIDWTAQFGADTRSWQVDREIFDQVLLDNAADSGAEVVQQAHVKRVLFDGDRAVGVEWQPAGGELRTETADYVIDASGRAGLISAQHYNNRRPHEIFRNVAIWGYWENAELLPDSPAGGINVISSPDGWYWLIPLRDNRFSVGFVTHKTNFVERRREFDSQEAMLAAVLGESETMKQVLAQATQLPGVRIEQDFSYAADKFCGDGYFLVGDSACFLDPLLSTGVHLAMYSGMLSAASILSLQRGEVNEPEAQAFFESLYRNAYHRLFTLVISFYQQHAGKDRYFALADTLSRAAQGDTQSADLAFGEIIAGLTDLREAADRAGTAAAPITETIDAAATGGAKPVQELLGAAEQARLRAEESSPNQRVTMAPMYIDANDLYDAASGLYLVTEPRLGISRVTSEAAVAAG,CCc1cc(O)cc(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C,CCc1cc(O)cc(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-4e78ccea6eff54be79b2,1,MEVEKVLQPISKSGESGYDHFMPEDFIRPEDEQPELTTFKGPTPDIPVIDLSEPDEEKLVRALVSASEEWGIFQVVNHGIPTDVIDKFMRVGREFFELPQEEKMAYARPPGATSLEGYETRFERDYVGKKAWADLLFHNVWPPSIVNYSFWPKNPPSYREATEEYAKHIPIVADKLFKILSLGLGLEGNTIKEGLGGEKMEFLMKINYYPPCPRPDLALGVVPHTGYPAMTILIPTDVPGLQVFKDDLWYDAKYIPYALVVNIADQIEILSNGKYKSVLHRAKVNKEKVRMSWPIFCTPPADMVIGPIPELINEENPSRYKYIEYKDYVQLKLKNKSAAFEGPNVAKVTSK,COC1=CC(=O)[C@]2(CC[C@@]34C(OC)=C(OC)C(=O)C[C@]32CCN4C)[C@@H]1O,COC1=CC(=O)[C@]2(CC[C@@]34C(OC)=C(OC)C(=O)C[C@]32CCN4C)[C@@H]1O,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-0457c48d8fc39719542a,1,MYDVVICGGGLAGLSLARQLKMTMPELSVLILEKTSGEVPVSPYKVGESLDETSNFYLSNILQLESYLQEHQLHKLGLRWFFGGGNLPLETRPEIGPPEFPSIRARHVDRKALENHLVQLNKESGVAHFTGVLVKDILLSEDDSPHEVLYTQQGGNHFTVKCRWLVDATGRRRYLQSKLNLTQPSGHRANAVWWQLEGKHSLDKMADDADWLSRNNHQRWFSTNHLMGDGYWVWVIPLITGNTSIGIVAAEEMHPLSKHSNYQSAMKWLEEHEPHFAKFIQTSTAQNFLAVKDFCYHSQQVFSEKRWSCVGDSAIFTDPFYSPGVVMLAYSNCLTVKMIELDHQNQLTAEIVQQFNNLLLRDIGHNYLQIYQDNYPVFGSFNVMSIKLFWDAVYIWFFPGALFFQQHFTNLEVLSNFSRIAQRYLALNQRVQKLFQDWGQAIKSQNFPCFLAYDISYKPTCLGKPRANGKRFFFDIFKEAHFSLVEKKDTQQYLADLEVQMQELEIWAQVIFRHALNQVMPERLSQFPEPFWVNVWAIGLNPEKWEEDRLFQPETEPQVDLRNYILAELPDDHYPPGAEPVTTSSVDNPAYVAAVN,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-a29ba90b650139bb2a6b,1,MTENSITAANVEELIAKNIAERFADDHEVLGLSQHFRREGYVKLPGLVSPEVFDAVAAETHQLIDTHQKRIDIRLKETGDSPRYMSTVGQKAIATDGSLIPAVYESTALKGFLSRLAKEEVMGCPWDEEKYIITRQHQKGDTHGWHWGDFSFTVIWLIEAPSLEYGGMLQCIPHTDWNKDDPRVEDYLQKHPIRSYGHAKGDLYLLRSDTTLHRTVPLNADRTRIILNTCWASRADQQKATTHETMNAMFD,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D0+:1]>>[C;D2+:1](-[Cl;D1:2])-[Cl;D1:3]
aries-halogenase-7dca45c32eb8330aca74,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYRGNFEEEFRNPWNNGSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-1877fbda982a46b74a09,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,C[C@H]1CCCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,C[C@H]1CCCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-b2c8e6d23d512b709af2,1,MSENQEYDVIVIGGGPGGSMVSSLLADGGKKVLVLEVAKFPRYHIGESLLLGTVDLLDKIGVREKLEAGDYIKKYGVEWVWGEQREPWKVDFRNAVSVTHDYTYQVERGPFDKMLLDNAREHGVDVREQHRVTNFSIDDNGRSTVNYRRTDTGETGTATARWLVDASGQGGLVTKRLHTQEWDPYLKNMAVWSYWKGVKRSEGEDAGNIFLPTFDDGWWWCIPLRDDITSIGAVVDRESLNALKSTRVRQYYLDSIEKTPELASRTENAELVDDMHVQRDWSYIYDRFCGDGYIAIGDAACFIDPLFSTGVHLAMLSGFLAATVVNTILDKPELDTARMLQFYEGAYRKEFARLRDQVYFLYAGNKGSKESYFWHARSHFGVPSIEPEKAFVSLIAGAFAHRAWYNHYAKHLDVSADLKKSVESMFNGAGIDLDTPLIASACGSVVNDFAVDGRYLREARSLVHTNGASIAYTPAVRAAVEHADGKRTGREIIEIITDRGIDSEDRARSIVHEVISYGFVEPKA,Nc1c(O)c2ccc(O)cc2oc1=O,Nc1c(O)c2ccc(O)cc2oc1=O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-71eebf8f5760b70c2eb1,1,MTSGNSSSAGFSPARRSLLLGGASTAALATLGTGTAAAAGQGTGPAAKPAAAAEFDFDTGNFHRDLLSTAANPSEEPLGPMDATVLVYLTHLTMTAWFDALAPYHPTAVGRHSRIPRRPASESNTNRNKNVAAFHAANVVFQSVFKERVAAFRQLMTTLGLDPDDQSTDPTSPVGIGNLAARGVLKAKARDGMNLFGDEGRKYHGQPYEDYTGFEPVNTAYKLVNPSKWQPARHPHRRRVGGGPGDKGIFVVQHMVTPQMALVKPDTYRHPSQFPLAPPDHLDHTDPRRYKRSVDEILEASATLDDEQKVKAEFFDNKFLGIGQSTKAAGIAHDLELDDWVHLIYTSSLAQVEDLIAAWHYKVKYQAPRPFSAIRHVYGKKKVSAWGGPGIGTVHDMPADEWASFLPVGDHPDYPSGSTTLCAAEAQAARRFLGDDRLDWTWPIPAGWTLTEPGITPARDMELHYGTWTEFVKDCGYSRLWAGVHFTTTVERSMEFGTQFGDLAYEFAQKYIKGDVED,CC(C)=CCC/C(C)=C/CC/C(C)=C/C[C@@]1(O)C(O)=C(Cl)C(=O)c2c(O)cc(O)cc21,CC(C)=CCC/C(C)=C/CC/C(C)=C/C[C@@]1(O)C(O)=C(Cl)C(=O)c2c(O)cc(O)cc21,[Cl;D1:1]-[C;D2+:2]=[C;D3+:3](-[O;D1:4])-[C;D3+:5](-[C;D1+:6])-[O;D1+:7]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:8])-[C@@;D4+:3](-[C;D1+:6])(-[O;D1:4])-[C;D2+:5]=[O;D1+:7]
aries-halogenase-a898a8776c1b93c5718b,1,MKHGGMASGAIERVVIVGGGTAGWMAAAALGAYLAGAGTRITLIESSEIGTIGVGEATIPTIRRFYAALGMTDAEVMRACEATAKLGIRFVDWKPGTSFVHPFGRFGQDLRGIDFHQYWQKARQAGRAAPLEEYSLGAMLAREGHASVPLPNPPSQLSVFDWALHFDAARFAAHMRAYAERAGVARIDARITDVTLHGETGFIEAVTLDSGERVAGDLFVDCSGFRGLLIGEALGTPYRDWSHWLLCDGAFAVQSERVGEPPSCTTVTARTAGWQWRIPLRSREGNGLVFASDFQGDDEARAELLANIPGAPTMEPRRLRFTPGRREVAWARNCVSLGLASGFLEPLESTSIALIETGIERLKQLFPDKGFDPAVIAEYNAQSAEEMERVRDFILLHYHLSTRDGPFWQACREMTLPDSLAAKLELWRARGAFLRYRWEMFSPASWLAIYGGFEHLPERLDPGVAAVGTDELAQGLEQMRAAIARTVADTPTHSEFLATVDGAAAEPMRTSV,c1ccc2[nH]ccc2c1,c1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-9841b7a33831ef01be43,1,MLDAIVMGGGPAGSVCAAVLARQGRSVLVLERQEFPRFHIGESMLPYMVGLLERHGLLDAVREQGYVVKRGGEFIDPTGTKFFRAGVFRADFAKTGDGRHHETFQVERSHFDRVNLDQARAAGATVREGAQVVGLLEEGGRVVGVRYREGGVEREERARYVVDATGRAGVVANRFGLRRMIEDLRMVAVFHHRDGLDEAHNPGHEGDIQVGSHSDGWIWAIPLSADRISVGTVMHRDRLRGRTPAEAFAEHVERVPRINQRLTGTSATSDFWVETDYSYHSDQVTGPGWVMVGDAGCFGDPMFSGGVLVGMATGAEAAEALGRALDSPADEEQALTGYSNFFKTGYDTYVRLIFSFYEGELLPALAEAHSEAGNLSEADMEMYVVRLLGGDFWSARNPVANALRANPAWSTFSPFEPVHRCPVYPELDVAELGGLAGTVGR,COC1/C=C/C=C(\C)Cc2cc(O)cc(c2)NC(=O)CC(O)/C(C)=C/C(C)C(O)CC1=O,COC1/C=C/C=C(\C)Cc2cc(O)cc(c2)NC(=O)CC(O)/C(C)=C/C(C)C(O)CC1=O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-895ea7bfb9e6d993dd42,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIHLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-24a05f4d1305d66770d1,1,MSVEDFDVVVAGGGPGGSTVATLVAMQGHRVLLLEKEVFPRYQIGESLLPATVHGVCRMLGVADELANSGFPIKRGGTFRWGARPEPWTFHFGISAKMAGSTSHAYQVERAKFDDILLKNAKSKGVVVREGCSVNDVVEDGERVTGARYTDADGNAHEVSARFVIDASGNKSRLYTKVNGSRNYSEFFRSLALFGYFEGGKRLPEPVSGNILSVAFDSGWFWYIPLSDTLTSVGAVVRREDADKIQGDREKALNTLIAECPLISEYLSNATRVTTGRYGELRVRKDYSYQQDSYWRPGMVLVGDAACFVDPVFSSGVHLATYSALLAARSINSVLAGDLDEKTALNEFEARYRREYGVFYEFLVSFYQMNVNEESYFWQAKKVTQNQSTDIESFVELIGGVSSGETALTAADRIAANSAEFAAAVDKMATGDGDDMVPMFKSTVVKQAMQEAGQVQMKALLGEDAEPELPLFPGGLVTSPDGMKWLPHHPA,N[C@@H](Cc1ccc(O)cc1)C(=O)S,N[C@@H](Cc1ccc(O)cc1)C(=O)S,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-27335c6f0f67cb71eb11,1,MNNPDALRKVCIVGGGTAGWIAAAVMAHHMKGRLFEIELVESDDIGTIGVGESTIPPFMELIAKLDIDEQDFVRQVQASFKLGIEFKDWFRKDESYFHPFGDVGQRVELSDFYQCWRKATLAGHDFPLQDFAPATVMAHAGRFMLPFKARNTPIAGASYALHVDAKRVAQFLRGHAEARGVKRTEGIVTDVALDARGFVSTLTLKDGRTIDADFFIDCSGFRALLIEKALGSGYTDWSNYLFCDRAIAAQTENVGPPRPYTLAEAQDAGWRWRIPLQHRTGNGHVYSSEFMSDEEATRILLEKVEGEVVAGPMVVPFRTGVREKIWHRNVLAIGLSSGFIEPLESTAIHLIYRGMDFFFRFLPDRHCDPALADEYNRRMVADYTEIRDFIVLHYCTTARDDTPFWRKCRDMDWPDSLKERVELFRSNGTLREGLDELFRSVSWFSVLEGMGIRPRTYHPLVDRIDEAMLYAGLDKAREQLAGFVRQLPTQQQFIDAHCRAEKVDLTRPVMAGV,c1ccc2[nH]ccc2c1,c1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-7db08657e1d436883b51,1,MADAMPKVIVIGGGPGGSTAAGLLAKGGVEVKLLERAEFPRYHIGESITTSCRAIIDYVGALEKVNACGFTTKTGVLMRWGQEKDWVIDWTAQFGADTRSWQVDREIFDQVLLDNAADSGAEVVQQAHVKRVLFDGDRAVGVEWQPAGGELRTETADYVIDASGRAGLISAQHYNNRRPHEIFRNVAIWGYWENAELLPDSPAGGINVISSPDGWYWLIPLRDNRFSVGFVTHKTNFVERRREFDSQEAMLAAVLGESETMKQVLAQATQLPGVRIEQDFSYAADKFCGDGYFLVGDSACFLDPLLSTGVHLAMYSGMLSAASILSLQRGEVNEPEAQAFFESLYRNAYHRLFTLVISFYQQHAGKDRYFALADTLSRAAQGDTQSADLAFGEIIAGLTDLREAADRAGTAAAPITETIDAAATGGAKPVQELLGAAEQARLRAEESSPNQRVTMAPMYIDANDLYDAASGLYLVTEPRLGISRVTSEAAVAAG,CCc1cc(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C,CCc1cc(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-00603386e33146708372,1,MGVVSADQAHLEILNSNPYETRDFFWEQHRFARDGYLKINHLIDPLVRDAIMVDVKYLMAHHAKRRDFLIESTGNTPRYLSNVSRDNIEEFGRYIPLAYKSQYLMSLIGNIVKEEVIPTPWKWDNYIINSQHKSGDTHGWHWGDYPYTIIWIVEAPSIECGGLLECVPHTNWDKKNPRVENLLVENSIDSYFHITGDVYLLKADTTLHRVKPLTKDVQRIILNTTWERARDRDRHVEHETFVFRD,CCCCC(N)C(O)O,CCCCC(N)C(O)O,[C;D0+:1]>>[C;D2+:1](-[Cl;D1:2])-[Cl;D1:3]
aries-halogenase-0673c84a150ae556f1a4,1,MDHYTHVQFDWARRNAAFDVRLRAAVQSRDASYSGDDGHVTNGDEARFPTTLLGTFTKGLPHSLPLALPTDRSAFDAFVSGVNTGDLDTIKSIPLGPDPEGDNSFSSSAMTTGAKVRGWESMAAGLAFTLEAPDPQRVTMPPAPQIDSVELGYELSESYWMALCRDIAFTEFDNSDTVAEAAASMAAHAWVAEDGCDQLGELTPTQTAHRELEMKNGEGITQGTIFRGSLNGDNIGPYLSQFLLIGCDTLGSRFSKDDPESYLTGHIRFGAHRIDQRVRKAVPDRDYMTTWGAYIDVANGADVRGRESYVTAEGDNFNDEETHRFIHTPRDLATYVHYDALYQPYINACLLMLAMGIEYDAGLPFGDEDEVDKQTGFALFGGPHILSLLAEVVLKALKAVRFQKFAMHRRARPETVAGWIDCVQRPRTSDEQEGNEGQTVFKPIEKLCQYVDSDLLQKVREHNVTQNNTQMDRDIARLYDYDPVDTVADCSAEQQEEQTEDEGQQQQQGGTYLLPMAYAEGSPMHPAYGAGHATVAGACTTILKAFFDTTQTLPYAFTSTEDGTKLTQIEVDEPLTVEGELNKLCSNISIGRNWAGVHWKSDYTESIKLGEEIAIGLLREQKNVYSEDFSMTIPLFDGSCVTV,C#C/C=C/C[C@@H](O)[C@H](O)C/C=C\C/C=C/CC,C#C/C=C/C[C@@H](O)[C@H](O)C/C=C\C/C=C/CC,[C;D2:1]-[C@;D3+:2](-[C;D3:3]-[O;D1:4])-[O;D1+:5].[C;D2:6]-[C;D2+:7]=[C;D2+:8]-[C;D2:9]>>[C;D2:1]-[C@@;D3+:2](-[C;D3:3]-[O;D1:4])-[O;D2+:5]-[C@;D3+:8](-[C;D2:9])-[C@@;D3+:7](-[Br;D1:10])-[C;D2:6]
aries-halogenase-deb2676eeef1cf8fc35f,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATHPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-739dbef65f3b1e4117d7,1,MDGLSGDPLPSTIAKDSIEGWWEMSVETFDVVVAGGGPGGSTVAALVAMQGHRVLLLEKEVFPRYQIGESLLPSTVHGVCRLLGVTDELAAAKFPVKRGGTFRWGARPEPWTFSFAVSPRMTGPTSFAYQVERARFDEILLNNAKSKGVTVREGCSVTAVVEEGDRVTGLRYTDSDGGEHEVGARFVIDASGNKSRLHASVGGTREYSEFFRSLALFGYFENGKRLPEPYSGNILSVAFDSGWFWYIPLSDTLTSVGVVVRREMAEKIQGDREKAYNALIAECPLIAEYLSDARRVTTGNYGELRVRKDYSYHQTKFWRPGMILVGDAACFVDPVFSSGVHLATYSALLAARSINSVLAGDLDEKTAFDEFEGRYRREYGVFYEFLVSFYQMNVNEESYFWHAKKVTNNEHTEFESFVDLVGGVASGETALAASRLAERSAEFAGAVDQMAGGDDGDMVPLFKSHVVKQVMQEGGQVQMKAVLGEDAAPEEPVFPGGLVSSPDGMKWLPYRG,N[C@@H](Cc1ccc(O)cc1)C(=O)S,N[C@@H](Cc1ccc(O)cc1)C(=O)S,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-982f632c9a223df334ee,1,MTAAYLKTAFGDRLSITVVESSRIGTIGVGEATFSDIQHFFQFLNLREQDWMPACNATYKLGIRFENWRHVGHHFYQPFEQIRPVYGFPLTDWWLHDAPTDRFDTDCFVMPNLCEAGRSPRHLDGTLADEDFVEEGDELANRTMSEHQGKSQFPYAYHFEAALLAKFLTGYAVDRGVEHVVDDVLDVRLDQRGWIEHVVTAEHGEIHGDLFVDCTGFRGLLLNKALGVPFVSYQDTLPNDSAVALQVPLDMQRRGIVPNTTATAREAGWIWTIPLFGRVGTGYVYAKDYLSPEEAERTLREFVGPAAADVEANHIRMRIGRSQESWRNNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKHFPAADWNPKSRDMYNSAVAHVMDGIREFLVIHYRGAARADNQYWRDTKTRPLPDGLAERIECWQTQLPDTETIYPYYHGLPPYSYMCILMGGGAIRTPASAALALTDQGAAQKEFAAVRDRAAQLRDTLPSHYEYLARMRGLDV,N[C@@H](Cc1c[nH]c2c(Cl)cccc12)C(=O)O,N[C@@H](Cc1c[nH]c2c(Cl)cccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-7b6d57a3fcb869bbe04a,1,MSIPKSCEVLVAGGGPAGSYAASALAREGVDVVLLEADKHPRYHIGESMLPSIRPLLRFIDLEETFEKHGFQKKLGAAFKLTAKREGYTDFVAAHGPNGYSWNVVRSESDELLFKHAAKSGALTFQGVKVDSLEFEPYDSDFPSGGKVANPGRPVAARWSAKDGRSGTISFQYLVDATGRAGITSTKYLKNRKFNEGLKNLAIWGYYKGARPWAEGTPRENQPYFEGMRDGAGWCWTIPLHNGTVSVGAVLRSDLFFAKKKSLGEDVTNAMIMAECMKLCPTIKELLEPAELVSDIKQATDYSYSASAYAGPYFRIVGDAGCFIDPFFSSGHHLAMAGALAAAVSIRASMKGDCSEYEASNWHARKVDEGYTLFLLVVMAALKQIRMQEEPVLSDIDDDGFDRAFQFLKPVIQGSGSAEIVKRFTKKEVSEAIDFAVLALDNMAGAGEHANETNGSNGTGETNGDAKTLENITVEDEKVLSGIRILAKVAPSADMKDLEGTAIDGFMPRLEHGHLGLNRV,C[C@@H]1C/C=C/CC/C=C/C(=O)Cc2cc(O)cc(O)c2C(=O)O1,C[C@@H]1C/C=C/CC/C=C/C(=O)Cc2cc(O)cc(O)c2C(=O)O1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-8a915123f912f4560665,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNPWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-33adbae8f83793cf6dd8,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12,COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-1d8090bacab301cac5ed,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,C[C@H]1CCCCCC(=O)Cc2c(Br)c(O)cc(O)c2C(=O)O1,C[C@H]1CCCCCC(=O)Cc2c(Br)c(O)cc(O)c2C(=O)O1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-d9c1554894e1814476a3,1,MSVPAQTSVLIVGGGPAGSYAATVLAREGVDVVLLEAEKFPRYHIGESMLASIRFFLRFVELEEEFDRHGFEKKYGATFKITEKNPAYTDFAASLGEGGYSWNVVRSESDEIIFRYAGKCGAKTFDGTKVESLTFEPYPHEGFDESVHLANPGRPVSANWSRKDGSSGVIKFDYIIDGSGRNGLISTKYLKNRSFNQGLKNIANWTYWKGAKRFNVGEKNENSPLFEALKDGSGWVWAIPLHNDTISVGVVARQDAFFEKKKESGLSGEAFYKEYLKLAPQIKNELLRDATIVSDIKQATDWSYSASAYAGPNFRLIGDAGCFVDPYFSSGCHLAMTSALSASVSIQAVRRGQCDELTGAKWHTTKVAEGYTRFLLLVMTVQRQLRMKDKNIISTDEEEGFDMAFKKIQPVIQGVADTRTEDEQTQRRAAEAVDFSLESFEITPEKQAAVISKIERSQAEPELLEKLTPEEVHILGNIVNRTFEREKDELNLTHFTGDMIDGYSAKLEHGNIGLYKREKALLNGTASRAAAVLKSIHQVA,COC(=O)c1cc(C(C)=O)cc(O)c1C(=O)c1c(O)cc(C)cc1O,COC(=O)c1cc(C(C)=O)cc(O)c1C(=O)c1c(O)cc(C)cc1O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-2594fcb40fdfda369d05,1,MSPSFVILGGGTAGWITAHLLERAWPDATITVVESPEIGTIGVGEGSTPSLKRFFEIIGAAEADWMPRCGATYKAGIRFVDWSPAAPWRDYRHPFTTQIDVHTEDAFILNCRNRRLGHDVPVRPDDFLLNGVLSAKGLAPVAPPNFPFRIEYGYHFDAGLLGQYLRELAVTRGVVHRPATVTTVRRAENGDIAALVTDREETIAGDIFVDCSGFNGLLIERTLGVPFHSFKDNLFNDAAVVVPTEMTGRPPVETVATALSNGWCWSIPLRHRVGNGYVYARDCQSPDAAETELRRTLGVSDAVPARHLTFRVGQVARHWERNCVAVGLSQGFIEPLEATALHLVLGTVEQFIRHYRDGGCTDRHRAAFNTVAAERMDGVRDYIVAHYKLNTRTDTDYWRANAANEALSDPLLHILDRWFRRGDIAEELARQGQRSHFGTLSWHCLLAGYGAFPPVSEARRDDMDFYAARRVGAFLEGCSRNFAPA,CC(C)NCC(O)COc1cccc2[nH]ccc12,CC(C)NCC(O)COc1cccc2[nH]ccc12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-73e91e1664210c0b5471,1,MALVTEVATRALKAVRFQKYNVHRRLRPEAVGGLLDRYRKDKRDPLYRPVAGLYKSLSPNLIRKVGQKNDSQNANQEDNGIPRSEDLRMEKRRRPPMLLPMAYPEGSPMHPSYGAGHATVAGACVTVLKAFFDHGFELPFAYVPSEYGTHLEKVRHLSDPLTVEGELNKLCGNISLGRSWAGVHYFSDYYESILLGERVAIGILEEQKLTYGERFSMTVPLFDGTEHEI,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-10acb87b3040f4e17778,1,MNTRRQQAQNIRNNAAELAANRPHPQHINNKEEYEYRRPKKDGNEPSHIANFTKGLPHDEHTGLLLNSADYDQFVLGIQSGDTTDFARTPLGPAELPKVHGCLSKQKIDCDDDHRSGFWKSQIAQGAAGGDGAKLRAWESAGAGLVFDLEGPDAQAVTMPPAPRLESPELTSEIAEVYSQALLRDIHFSQLRDPGLGDQVNACDSCPTQLSIYEAIDILNTVQIEGQNWFSANCCDLTDDEQARQRPLVTRQNIFRGIAPGDDVGPYLSQFLLIGNNALGGGVFGQEAGHIGYGAIRIDQRVRKATPCKDFMTNFETWLDVQNGADLRGLETYVDADPGKCREFPAYRVITTPRDLATYVHYDALYEAYLNACLILLGMGAPFDPGIPFQKPDVEDKQQGFAHFGGPQILTLVCEAATRGLKAVRFQKFNVHRRLRPEALGGLVDRYKHGKGAGDELKPVAALVEALENVGLLSKVVAHNQLQNQNLDRSGDPSSAGDNYFLPMAFPEGSPMHPSYGAGHATVAGACVTMLKAFFDHGWQLNLGMANGKYISYEPNQDGSSLQQVLLDCPLTVEGELNKIAANISIGRDWAGVHYFTDYIESLRLGEKIAIGILEEQKLTYGENFTMTVPLYDGGSIQI,COc1cc(OC)cc(OC)c1,COc1cc(OC)cc(OC)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-37df889efd442031f861,1,MLEVCIIGFGFSAIPLVRELARTQTEFQIISAESGSVWDRLSESGRLDFSLVSSFQTSFYSFDLVRDYEKDYYPTAKQFYEMHERWRSVYEEKIIRDFVTKIENFKDYSLISTRSGKTYEAKHVVLATGFDRLMNTFLSNFDNHVSNKTFVFDTMGDSANLLIAKLIPNNNKIILRTNGFTALDQEVQVLGKPFTLDQLESPNFRYVSSELYDRLMMSPVYPRTVNPAVSYNQFPLIRRDFSWVDSKSSPPNGLIAIKYWPIDQYYYHFNDDLENYISKGYLLNDIAMWLHTGKVILVPSDTPINFDKKTITYAGIERSFHQYVKGDAEQPRLPTILINGETPFEYLYRDTFMGVIPQRLNNIYFLGYTRPFTGGLANITEMQSLFIHKLITQPQFHQKIHQNLSKRITAYNQHYYGAAKPRKHDHTVPFGFYTEDIARLIGIHYQPNECRSVRDLLFYYAFPNNAFKYRLKGEYAVDGVDELIQKVNDKHDHYAQVFVQALSIRNMNSDEAAEWDHSARRFSFNDMRHKEGYRAFLDTYLKAYRQVENISVDDTVVDEEWNFMVKEACQVRDKVAPNIEEKTHYSKDEDVNKGIRLILSILDSDISSLPDSNGSRGSGNLKEGDRLCKFEAQSIEFIRRLLQPKNYELLFIRESTVSPGSHRHGETA,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-933b7d8e3c4f07686e72,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Oc1cccc2ccccc12,Oc1cccc2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-487e4a2ed2f8e9b2ef24,1,MIRKVAIVGGGTAGWMTASYLKAAFADRLDVTLVESEAVGRIGVGEATFSTVRHFFDYLGLDEADWLPKCEGGYKLAIRFENWAKQGHHFYHPFERLRKADGFSLAEWWLALGDHSQPFDRQCFVTSALCEAKRSPRMLDGSLFATGLDGSLGRSSLAEQRAQFPYAYHFDADKVAAFLAAYSKERGVRHIVDDVVHSALDDRGWISHVQTRGGLRLDADLFIDCTGFRGALINKLMGEPFESFQDVLPNNRAVATRVSRPEITDMNPYTTATAMDAGWMWRIPLFHRDGVGYVYSDEFASPEEAERTLRTQVGDLRGELDVNHIAMRVGRCRDSWVKNCVAIGLSSAFVEPLESTGIFFIQHGIEQLVKHFPDERWDPELTRNYNTRIAQAVDGVKEFLVLHYRGAARSDNDYWRAAKTRKAPDGLVERMEQALPHLIDEEATYPYYHGFEPYSWNTMLLGLGNQPARARPALAHMDPARARAEFDLLRAEANAVIEKLPSCYEYLERIHTP,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-76a23395000b22f2e62a,1,MHGTHGRSDGTGGPGGGFAEEFRSFVASLQADEARTLRRWLDEAPDAPAPGPAAGPDGGAPPAPDLEALFRDGESAPRDAGMDPTLRPRSDDPRAVRRIGVIGGGTAGYLTALALRAKRPWLEVTLVESSGIPIIGVGEATTPSMVPFLHHYLGIDAQELYEAVQPTWKLGIRFDWGARPEGFMAPFDWGSNSIGVLGSLATRDSINSFTLQSLLMEQDKVPVFDLGGGRHMSLMKRLPFAYHLDNQRFVRFLTELARKRGVGHLDARIERVVLDEETGWVDHLETDDGRRVDFDLYVDCSGFRSLLLGQAMGSPEVSFADSLFTDRAVTAVVPHDGTIKPYTRATTMDAGWCWTIPTRDDDHVGYVHSSRFISVEEATAELRRLYPRAHTFRTVHFRSGRHQEAWRGNVMAIGNSYAFVEPLESSGLMMITLGILSLVSSLPGSWSQPCPRQVVNAALAKKWDEIRWFLALHYRFNTRKDTPFWRTCREEADISGLEPLLEVFSGGAPLRFRDPVVRSFLESTAPTFYGLEGVDCLLLGQGHPTRLLPMTEPVQAWRQREEAAQVLVSHAVDAATALRSFDRDARLNTQLLENEDSWVVRTGTDRLVSADPDA,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-fc0acc74b0ae025e2e0e,1,MSIPKSCEVLVAGGGPAGSYAASALAREGVDVVLLEADKHPRYHIGESMLPSIRPLLRFIDLEETFEKHGFQKKLGAAFKLTAKREGYTDFVAAHGPNGYSWNVVRSESDELLFKHAAKSGALTFQGVKVDSLEFEPYDSDFPSGGKVANPGRPVAARWSAKDGRSGTISFQYLVDATGRAGITSTKYLKNRKFNEGLKNLAIWGYYKGARPWAEGTPRENQPYFEGMRDGAGWCWTIPLHNGTVSVGAVLRSDLFFAKKKSLGEDVTNAMIMAECMKLCPTIKELLEPAELVSDIKQATDYSYSASAYAGPYFRIVGDAGCFIDPFFSSGHHLAMAGALAAAVSIRASMKGDCSEYEASNWHARKVDEGYTLFLLVVMAALKQIRMQEEPVLSDIDDDGFDRAFQFLKPVIQGSGSAEIVKRFTKKEVSEAIDFAVLALDNMAGAGEHANETNGSNGTGETNGDAKTLENITVEDEKVLSGIRILAKVAPSADMKDLEGTAIDGFMPRLEHGHLGLNRV,CC(=O)c1ccc(O)cc1O,CC(=O)c1ccc(O)cc1O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-7bf0aff635f4212516ce,1,MNTRNPDKVVIVGGGTAGWMTASYLKKAFGERVSVTLVESGTIGTVGVGEATFSDIRHFFEFLDLREEEWMPACNATYKLAVRFQDWQRPGHHFYHPFEQMRSVDGFPLTDWWLQNGPTDRFDRDCFVMASLCDAGRSPRYLNGSLLQQEFDERAEEPAGLTMSEHQGKTQFPYAYHFEAALLAEFLSGYSKDRGVKHVVDEVLEVKLDDRGWISHVVTKEHGDIGGDLFVDCTGFRGVLLNQALGVPFVSYQDTLPNDSAVALQVPLDMEARGIPPYTRATAKEAGWIWTIPLIGRIGTGYVYAKDYCSPEEAERTLREFVGPEAADVEANHIRMRIGRSEQSWKNNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKHFPAGDWHPQLRAGYNSAVANVMDGVREFLVLHYLGAARNDTRYWKDTKTRAVPDALAERIERWKVQLPDSENVFPYYHGLPPYSYMAILLGTGAIGLRPSPALALADPAAAEKEFTAIRDRARFLVDTLPSQYEYFAAMGQRV,Cn1cc(C[C@H](N)C(=O)O)c2ccccc21,Cn1cc(C[C@H](N)C(=O)O)c2ccccc21,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-02141810795aab0ec079,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNPWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-72abacb094771a0a64a5,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,COC(=O)c1ccc(N)cc1O,COC(=O)c1ccc(N)cc1O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-afc1690a331258665aed,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVATNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-2c80c314a06d8420bb22,1,MTTSGIATVPASSLGRRSLLIGGAATLPLSQLVFARTAGAATEEPPELPDLDKDNYVKWAQPGDDRAGQSPSLQFIGPMDATVFLWTNRAAMLSAFDALAPYHETALGIHSRIPRRPSSESTTNRNMNIAVIYAQHGIWKRLLPENVGALRQLMTALGLNPDDESENLTSPIGIGNVAAKSVWKFLESDGMNLLGDEGGRKYNRVPWRDYTGYVPVNTPYRVHNPSRWQPQLGPHNGRRLGGGPGDLGIYVGQHFVTPQSARTKAHIFDHPARFDVGPPRHSDHTNPRVYKRSVDEILEASATLTDERKVMAEIMDNKLWGIGHSSIVIARKRDEDNHMGVHGWAQWVLQSILSTFDTLIADWHLKAKYDAVRPLTAVRHVYGNRKITAWGGPGMGTVDDIRASEWTSYLPTGDHPEYPSGSTTLCAAGSQNTRRFFGDDVLDWTFTFPAGTSLAEPGVTPAKDVEVHFPTWTAFDKACAQSRVDGGVHFTKTVERSIRFGEQFGDLTHEYVQRQVRGDVKD,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-2358a16af9f6bd7cb611,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,CNS(=O)(=O)Cc1ccc(N)cc1,CNS(=O)(=O)Cc1ccc(N)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-8d7c658f9476ff2c201e,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Cc1ccc2[nH]cc(CCN)c2c1,Cc1ccc2[nH]cc(CCN)c2c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-c5d2467e828528e31aff,1,MKTVNFLSHLNDLGINVWVENDKLRYRSPKGVIIPELLQELKERKEELIAFLRQQAEDLNQAETYDVVICGGGLAGLTLARQLKLQKPNMAIAVLDKMSGLSPEASFKVGESTVEVGAFYLANTLQLTDYFEEQHLVKLGLRYFFNNSATNFQERPELGLSEFHAPNSYQIDRGKLENDLRQFNMEAGVELREGCLVNEIALAEGLQQHHKVVYTQGDGDNRKNKIIKARWVVDAMGRRRFLQRKLGLDKPNNDNFGAVWFRVNGRFDIGDFVPSSEEKWHNRVPNKNRYYSTNHLCGEGYWVWTIPLSTGHTSIGIVARQDIHPLKNYYNYELAYQWLQKNEPVLACHLKDKEPEDFRKMPKYSYSSKQVFSSNRWACVGEAGTFPDPFYSPGTDNIGFGNSLTTQLIALDLEDKLTKEKVEDANYFYISYSDGVTLNIQNAYNCLGNGIVMATKFIWDTLSGWTFSGLMMFNSIFLDQDFRTRVQEINSKFFPLSYRMQQLFRDWANKSLNRVNFEFIDYLAIPFVDELRTRNLKSNKTKSEIIENYLSSLKLLEEVAQVMFHLALEDTMPDMLSKVNSNSWLNAWAISLDISKWEADGLFTPKSEPRNLNLIKQQLWEAIGK,N[C@@H](Cc1ccc(O)cc1)C(=O)S,N[C@@H](Cc1ccc(O)cc1)C(=O)S,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-0c38972c44d623312ef3,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLEGSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-3d3390390ee9ab65d0fd,1,MSDHDYDVVIIGGGPAGSTMASYLAKAGVKCAVFEKELFEREHVGESLVPATTPVLLEIGVMEKIEKANFPKKFGAAWTSADSGPEDKMGFQGLDHDFRSAEILFNERKQEGVDRDFTFHVDRGKFDRILLEHAGSLGAKVFQGVEIADVEFLSPGNVIVNAKLGKRSVEIKAKMVVDASGRNVLLGRRLGLREKDPVFNQFAIHSWFDNFDRKSATQSPDKVDYIFIHFLPMTNTWVWQIPITETITSVGVVTQKQNYTNSDLTYEEFFWEAVKTRENLHDALKASEQVRPFKKEADYSYGMKEVCGDSFVLIGDAARFVDPIFSSGVSVALNSARIASGDIIEAVKNNDFSKSSFTHYEGMIRNGIKNWYEFITLYYRLNILFTAFVQDPRYRLDILQLLQGDVYSGKRLEVLDKMREIIAAVESDPEHLWHKYLGDMQVPTAKPAF,O=C(S)c1ccc[nH]1,O=C(S)c1ccc[nH]1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-89c6d52042f5a614bbd7,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATMPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPFGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-5b382a8191264f074a52,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,CC(=O)NC1CNc2ccccc2C1,CC(=O)NC1CNc2ccccc2C1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-c69f0baaa1af7cebe999,1,MSTHFLGKVKFDEARLAEDLSTLEVAEFSSAYSDFACGKWEACVLRNRTGMQEEDILVSHNAPALATPLSKSLPYLNELVETHFDCSAVRYTRIVRVSENACIIPHTDYLELEETFTRLHLVLDTNSGCANTEEDKIFHMGLGEIWFLDAMLPHSAACFSKTPRLHLMIDFEATAFPESFLRNVEQPVTTRDMVDPRKELTDEVIEGILGFSIIISEANYREIVSILAKLHFFYKADCRSMYDWLKEICKRRGDPALIEKTASLERFFLGHRERGEVMTY,O=C(O)[C@@H]1CCCN1,O=C(O)[C@@H]1CCCN1,[C;D2:1]-[C;D2+:2]-[C;D3:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D3:3]
aries-halogenase-6219b932485fb6275fcf,1,MSIPNRCTVLVVGGGPAGSYAAAALAREGVDTVLLEADVFPRYHIGESMLPSIRHFLRFIDLDSKFDSYGFVNKNGAAFKLNSKPEAYTDFIAAGGPGSHAWNVVRSEADHLMFKHAGENGAQVFDGVKVNSIEFEQIDGLTVDPSLSELGRPVSATWSCKATGGKGSITFEYLIDATGRAGLVSTKYMKNRRYNQGLKNVASWGYWSNAGSYGVGTPREGDPYFEAIEDGSGWVWLIPLHNGTTSIGVVMNQEAATAKKRETGATTKDLYLNTIKNTPGVWQLLDKAELQSDLKSASDWSYNASSYASPYLRIVGDAGCFIDPFFSSGVHLALASGLSAALTIRAAQRGDCDEQAAVSWHSKKVAEGYTRFLLVVMSALKQISDREKPVLTDFDEDSFNRAFDFFRPIIQGTADVDKNLTQAEIAQTIEFCVQAFQTASTDEQDAVMTKVAAINSQNGTEGALRELHASLSADERRTLTTIQARQIIRSEDQMNIDNFTIDVIDGMVPRLERSSLGLARFVPKAQTSREDGLRATLGLPEKQKSIFSY,CON1C(=O)[C@@H]2NC(=O)[C@@]13Oc1cc(O)ccc1[C@@H]3SS2,CON1C(=O)[C@@H]2NC(=O)[C@@]13Oc1cc(O)ccc1[C@@H]3SS2,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-ae1f31e1ba28b07bde59,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,Nc1cccc2[nH]ncc12,Nc1cccc2[nH]ncc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-52c5a260883bb90127ee,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,COC(=O)c1ccc(N)cc1O,COC(=O)c1ccc(N)cc1O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-460143e6473f0614a14d,1,MINSVLIVGGGTAGWMTAAYLSKAFDKNINITVVESKEVKKIGVGEATFSTVRHYFDYLGLNESEWLPECSGSYKLGIRFENWDGQGNHFYHPFERWEVVKGFPISEWWLSKKLKDQRFDYDTFLTPHLCEAKRSPRRLDGSLFAQSIDKSLGQSTLAEQRAQYPYAYHFDADGVASFLKRYAMNRGVKHIEDDVTHVEIDTNGNIGYLEAKIYGKLRADLYIDCTGFKGLLINKALNEPFISFSDVLKNNRAVALRVPRENENDIEPYTTARTMSNGWRWTIPLYKRNGYGYVYCNKYQSPEEAEMELRKSIPYENAECVANHIRMRIGRSNRSWVKNCVAIGLSSAFVEPLESTGIFFIQHGIEQLVRFFPRSSGNELLIEEYNTRVNRVVDGVKEFLLLHFSLAQRNDTLYWKEWKNVELPKELLKKITLAQDHLLDKETIYPFYHGFEEYSWNTMILGLCSGSLNNKPALSLMTSDEADEMLLQHYMKAENMVNNLPTCYEYLKHIHDLKNKN,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-7421ff69b2a0f7c0a619,1,MKHGGMASGAIERVVIVGGGTAGWMAAAALGAYLAGAGTRITLIESSEIGTIGVGEATIPTIRRFYAALGMTDAEVMRACEATAKLGIRFVDWKPGTSFVHPFGRFGQDLRGIDFHQYWQKARQAGRAAPLEEYSLGAMLAREGHASVPLPNPPSQLSVFDWALHFDAARFAAHMRAYAERAGVARIDARITDVTLHGETGFIEAVTLDSGERVAGDLFVDCSGFRGLLIGEALGTPYRDWSHWLLCDGAFAVQSERVGEPPSCTTVTARTAGWQWRIPLRSREGNGLVFASDFQGDDEARAELLANIPGAPTMEPRRLRFTPGRREVAWARNCVSLGLASGFLEPLESTSIALIETGIERLKQLFPDKGFDPAVIAEYNAQSAEEMERVRDFILLHYHLSTRDGPFWQACREMTLPDSLAAKLELWRARGAFLRYRWEMFSPASWLAIYGGFEHLPERLDPGVAAVGTDELAQGLEQMRAAIARTVADTPTHSEFLATVDGAAAEPMRTSV,c1cnc2[nH]ccc2c1,c1cnc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-395a0b5c728744975f60,1,MNKPIKNIVIVGGGTAGWMAASYLVRALQQQANITLIESAAIPRIGVGEATIPSLQKVFFDFLGIPEREWMPQVNGAFKAAIKFVNWRKSPDPSRDDHFYHLFGNVPNCDGVPLTHYWLRKREQGFQQPMEYACYPQPGALDGKLAPCLSDGTRQMSHAWHFDAHLVADFLKRWAVERGVNRVVDEVVDVRLNNRGYISNLLTKEGRTLEADLFIDCSGMRGLLINQALKEPFIDMSDYLLCDSAVASAVPNDDARDGVEPYTSSIAMNSGWTWKIPMLGRFGSGYVFSSHFTSRDQATADFLKLWGLSDNQPLNQIKFRVGRNKRAWVNNCVSIGLSSCFLEPLESTGIYFIYAALYQLVKHFPDTSFDPRLSDAFNAEIVHMFDDCRDFVQAHYFTTSRDDTPFWLANRHDLRLSDAIKEKVQRYKAGLPLTTTSFDDSTYYETFDYEFKNFWLNGNYYCIFAGLGMLPDRSLPLLQHRPESIEKAEAMFASIRREAERLRTSLPTNYDYLRSLRDGDAGLSRGQRGPKLAAQESL,CCNC(=O)c1ccccc1N,CCNC(=O)c1ccccc1N,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-35eb479ee85628b90d5a,1,MDVPLMELSGRAPVVRLHDIEADMAAATDAIRSQLTGWGFMAAEVPGIGERVEAMMNEFAAACRATGPSLSDYAYDVVPQLAVGGTHGFFPYNSEIPRLANGVPDPKEFIHVSGAMIGDQPPGAGDVLRAFPAFGTRAAEVFDIAFRLISLFGEVVRGMMPPGTPELDLSHDATNLRVIHYRDVGDREVLAHEHSGIQMLGLQLPPSDQGLQYVLHDGTWVEPVIAGTDVVLCNIGRMLTSASDGRFRPSTHRVHTKPMPAGYERLSSVLFAAPQHKARQWKMVDGELMSLNATWGDFIDSRFQGLGKQS,COP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C[C@@H]1O,COP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C[C@@H]1O,[C;D3:1]-[C;D2+:2]-[C;D3:3]>>[C;D3:1]-[C@;D3+:2](-[Cl;D1:4])-[C;D3:3]
aries-halogenase-3f703336ec8defe45609,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAILLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-5c3d91e81ae5415769fc,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSSYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,C=CC(C)(C)c1[nH]c2ccccc2c1CCNC,C=CC(C)(C)c1[nH]c2ccccc2c1CCNC,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-35548a435e631dc5ee6a,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATFPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNCWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-5cd53812071ab9bb11d1,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYRGNFEEEFRNPWRNGSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-af864b0a4f77d494f9de,1,MSVEDFDVVVAGGGPAGSTVATLVAMQGHRVLLLEKEVFPRYQIGESLLPATVHGVCRMLGITDELANAGFPVKRGGTFRWGARPEPWTFHFGISAKMAGSTSHAYQVERARFDEILLNNAKRKGVVVREGSPVTDVVEDGERVTGLRYTDADGNEREVSARFVIDASGNKSRLYSKVGGSRNYSEFFRSLALFGYFEGGKRLPAPVSGNILSVAFDSGWFWYIPLSDTLTSVGAVVRREDAEKIQGDREKALNALIAECPLISEYLANATRVTTGKYGELRVRKDYSYQQETYWRPGMILIGDAACFVDPVFSSGVHLATYSALLAARSINSVLAGDLDEKTALNEFEMRYRREYGVFYEFLVSFYQMNVNEESYFWQAKKVTQNQSTDIESFVELIGGVSSGETALTAADRIAARSAEFAAAVDQMASGDGDNMVPMFKSTVVKQAMQEAGQVQMKALLGEDAEPELPLFPGGLVTSPDGMKWLPHHPA,N[C@@H](Cc1ccc(O)cc1)C(=O)S,N[C@@H](Cc1ccc(O)cc1)C(=O)S,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-5bba8f46cdedf6b48777,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIVLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-678f2f24525785e9460d,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKHPFPSYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-75d93dbee6612095e770,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIFLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-1b0c00bf165404fa5094,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVHTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-63d5537f693522a87282,1,MDVPLMELSGRAPVVRLHDIEADMAAATDAIRSQLTGWGFMAAEVPGIGERVEAMMNEFAAACRATGPSLSDYAYDVVPQLAVGGTHGFFPYNSEIPRLANGVPDPKEFIHVSGAMIGDQPPGAGDVLRAFPAFGTRAAEVFDIAFRLISLFGEVVRGMMPPGTPELDLSHDATNLRVIHYRDVGDREVLAAEHSGIQMLGLQLPPSDQGLQYVLHDGTWVEPVIAGTDVVLCNIGRMLTSASDGRFRPSTHRVHTKPMPAGYERLSSVLFAYPQHKARQWKMVDGELMSLNATWGDFIDSRFQGLGKQS,COP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C[C@@H]1O,COP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C[C@@H]1O,[C;D3:1]-[C;D2+:2]-[C;D3:3]>>[C;D3:1]-[C@;D3+:2](-[Cl;D1:4])-[C;D3:3]
aries-halogenase-0f96adffa837c67a62f7,1,MLLGGASTAALATLGTGTAAAAGQGTGPAAKPAAAAEFDFDTGNFHRDLLSTAANPSEEPLGPMDATVLVYLTHLTMTAWFDALAPYHPTAVGRHSRIPRRPASESNTNRNKNVAAFHAANVVFQSVFKERVAAFRQLMTTLGLDPDDQSTDPTSPVGIGNLAARGVLKAKARDGMNLFGDEGRKYHGQPYEDYTGFEPVNTAYKLVNPSKWQPARHPHRRRVGGGPGDKGIFVVQHMVTPQMALVKPDTYRHPSQFPLAPPDHLDHTDPRRYKRSVDEILEASATLDDEQKVKAEFFDNKFLGIGQSTKAAGIAHDLELDDWVHLIYTSSLAQVEDLIAAWHYKVKYQAPRPFSAIRHVYGKKKVSAWGGPGIGTVHDMPADEWASFLPVGDHPDYPSGSTTLCAAEAQAARRFLGDDRLDWTWPIPAGWTLTEPGITPARDMELHYGTWTEFVKDCGYSRLWAGVHFTTTVERSMEFGTQFGDLAYEFAQKYIKGDVED,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-98eb1f769cc46eb269eb,1,MDEIDDPRIRSVVIVGGGTAGWMTAAALVQHFRTAPLKITVVESSDIGTIGVGEATIPTIRRFYGQLGLRDDDVMRATQATCKLGIRFLDWSGPGSDFIHPFGLYGQDVKGIGFHHYWLKQRRAGDAAPLAAYSLGAALAAGGKFTLPSPHPPSQLSVFDWALHLDAGLFAQHLRAYAEAGGCARIDARIRSVELRPEDGFVRALTLDDGREVEGDLFVDCSGFKGLVIGEALGVGFEDWGRWLPCDAAYAVQSENRPGDAPAPFTRVTARSAGWQWGIPLRHRAGNGLVFSSAHLSDDQALAELMPHLLGDPLTEPRRIPFRPGRRSQAWAKNCVAIGLSSGFLEPLESTSIALIETGIERLKALFPDRRFAQPILDEFNDQTAREMERVRDFIILHYKLNRRTDTDFWRDCREMPVPETLERKIALWTARGQFVRYRWEMFHPASWLAIYDGFGLYPDHHDPAVDAMDPAYLARSLAEMRANIADLVARTPEHAQFLAGLDPAASAA,O=[N+]([O-])c1ccc2[nH]ccc2c1,O=[N+]([O-])c1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-9e12d26cd7b91b7cafe4,1,MKHGGMASGAIERVVIVGGGTAGWMAAAALGAYLAGAGTRITLIESSEIGTIGVGEATIPTIRRFYAALGMTDAEVMRACEATAKLGIRFVDWKPGTSFVHPFGRFGQDLRGIDFHQYWQKARQAGRAAPLEEYSLGAMLAREGHASVPLPNPPSQLSVFDWALHFDAARFAAHMRAYAERAGVARIDARITDVTLHGETGFIEAVTLDSGERVAGDLFVDCSGFRGLLIGEALGTPYRDWSHWLLCDGAFAVQSERVGEPPSCTTVTARTAGWQWRIPLRSREGNGLVFASDFQGDDEARAELLANIPGAPTMEPRRLRFTPGRREVAWARNCVSLGLASGFLEPLESTSIALIETGIERLKQLFPDKGFDPAVIAEYNAQSAEEMERVRDFILLHYHLSTRDGPFWQACREMTLPDSLAAKLELWRARGAFLRYRWEMFSPASWLAIYGGFEHLPERLDPGVAAVGTDELAQGLEQMRAAIARTVADTPTHSEFLATVDGAAAEPMRTSV,Cc1ccc2[nH]ccc2c1,Cc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-d2ee474d84892ab06ec1,1,MKHGGMASGAIERVVIVGGGTAGWMAAAALGAYLAGAGTRITLIESSEIGTIGVGEATIPTIRRFYAALGMTDAEVMRACEATAKLGIRFVDWKPGTSFVHPFGRFGQDLRGIDFHQYWQKARQAGRAAPLEEYSLGAMLAREGHASVPLPNPPSQLSVFDWALHFDAARFAAHMRAYAERAGVARIDARITDVTLHGETGFIEAVTLDSGERVAGDLFVDCSGFRGLLIGEALGTPYRDWSHWLLCDGAFAVQSERVGEPPSCTTVTARTAGWQWRIPLRSREGNGLVFASDFQGDDEARAELLANIPGAPTMEPRRLRFTPGRREVAWARNCVSLGLASGFLEPLESTSIALIETGIERLKQLFPDKGFDPAVIAEYNAQSAEEMERVRDFILLHYHLSTRDGPFWQACREMTLPDSLAAKLELWRARGAFLRYRWEMFSPASWLAIYGGFEHLPERLDPGVAAVGTDELAQGLEQMRAAIARTVADTPTHSEFLATVDGAAAEPMRTSV,N#Cc1ccc2[nH]ccc2c1,N#Cc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-c7e92bac8729cf4c3b5d,1,MLESIVVVGGGTSGWMTASYLSAAFGERISVTVVESARVGTIGVGEATFSTVRHFFEYLGLSEETWMPACNATYKLGIRFENWRAPGHHFYHPFERQRVVDGFTLPDWWLADGGATERFDKECFLVGTLCDTMRSPRHMDGALFEGDLTDRPAGRSTLAEQGTQFPYAYHFDAALLADFLRDYAVARGVLHVVDDVVHVARDERGWISHVATRGSGDLAGDLFVDCTGFRGLLINDALDEPFESYQDTLPNDSAVALRVPVDMEREGLRPCTTSTAQAAGWIWTIPLFGRVGTGYVYARDYCTPEEAERTLRRFVGPAADDLEANHIRMRIGRSRRSWVNNCVAVGLSSGFVEPLESTGIFFIQHAIEQLVKHFPDADWDPALRSAYNTLVNRCMDGVREFLVLHYYGAARADNEYWRDTKTRKIPDSLAERVEQWRTKLPHPESVYPHYHGFEAYSYVCMVLGLGGIPLKPSPALRMLDPSAAQREFRLLATQAEDLRRTLPSQYAYFAQFR,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-043b901f48c813cfb6c1,1,MKIESVAIVGGGSSGWMTAAALSKLCPQLEIALIEDPNIKTVGVGESTLGHFNKFLHLLDLKDEDWMPACNATYKNSIRFTNFREGKGEVFEYPFGPSLDVSFFSQTDGINTWGKLANKYPEDFPPETFARFVNSNTYLAEHNRLTRNKDNKIPNFNFDWDTAYHIDAELFGQYLKEKIALPNGVKHIQGKVTGYQKESPNNHNFKYIILDQETAIFADLYIDCTGFKSLLLGEFMGEAFSPFSKKLANDKAMATRIPYENREEEMHNVTDCHAMKNGWVWNIPLWNRIGTGYCYSSRFVSKDDAEAEFREHLGERGKDAKIFHIDIGHGKRTRAWVNNCVGIGLSYGFIEPLESTGLLTTHENIENLVYLINQRDGYVTQAERDGFNYTCDHQIDSFSDFVAMHYAYSMRTDTPYWKWCTQMCNYMPESMGPHRQKQSTWQDLSTDTIGLNTWHINHNGISFIIAGHGLRPQSYDKLSEVLLKRNNESDYYYEDIRKDWLKHYESMVEYVKTLPTHYEFLRDEIYGSAE,Cc1cc(N)on1,Cc1cc(N)on1,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-08a05c4b716c9953e044,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYRGNFEEEFRNPWRNGSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-0f179fbfd346fdd67b2f,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATMPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPFGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-c3b109c7b1e3166e6653,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVFTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,C=CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C=CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-7c87b3a3ff2703959a1a,1,GSHMNGFTHYDVVIIGSGPAGSLCGIECRKKGLSVLCIEKEQFPRFHIGESLTGNAGQIIRDLGLAEDMDAAGFPDKPGVNVIGSLSKNEFFIPILAPTWQVRRSDFDDMIKRKAVEHGVEYKLGMVTDVIKDGEKVVGALYKADGVEHQVRSKVLVDASGQNTFLSRKGVAGKRQIEFFSQQIASFAHYKGVERDLPPFSTNTTILYSKQYHWSWIIPISPDTDSLGVVIPKDLYYKECKNPDDAIAWGMDHISPELKRRFKNAERQGDSQSMADFSYRIEPFVGDGWMCIGDAHRFLDPIFSYGVSFAMKEGIRAAEAIAQVVAGQDWKAPFYAYRDWSNGGQQIAADLIRYFWIYPIFFGYQMQNPDLRDEVIRLLGGCCFDCEGWKAPAIFRNAIEEYDRKQMAS,O=C(S)c1ccc[nH]1,O=C(S)c1ccc[nH]1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-98968c513b70a24d01d5,1,MSNNAVSTKSALNFLDINVTEVNNYPTAIQDIIIDRRFDGMIIRGVLPLDSIERVIRRLEDEDEGGMKLIFNKNEEFGTKVAQIYGHVIVGQSPDLKDYFASSAIFRQACRALFQGNPDFEERVESVFHSLCGLPVEIPTGPEGQSYTPATLRLLTEGREITVHVGNDFLLMPASEHLKTLLDFSDQLSYFIPLSVPQAGGELVVYNLEWNPEQAEQSGDLHKYMNDADSRFQSQQSQSVAFAPGPGDMILFNGGRYYHRVNQVIGNSPRRTIGGFLAFSKERNKIYYWS,C=C[C@]1(C)CC[C@H](C(=C)C)[C@@H](c2c[nH]c3ccccc23)[C@H]1C#N,C=C[C@]1(C)CC[C@H](C(=C)C)[C@@H](c2c[nH]c3ccccc23)[C@H]1C#N,[C;D2:1]-[C;D2+:2]-[C;D4:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D4:3]
aries-halogenase-b55184dec351ac66077c,1,MDVHEIDETLEKFLAENYTPERVQQLADRFQRTGFVKFDSHMRIVPEELITAVRAEADRLVREHKERRDLVLGTTGGTPRNLSVVKSQDVEQSDLIRAVTRSEVLLTFLAGITRERIIPEVSDDERYLITHQEFASDTHGWHWGDYSFALIWALRMPPIASGGMVQAVPHTHWDKNAPRINETLCERQIDTYGLVSGDLYLLRSDTTMHRTVPLTEDGAVRTMLNVSWSAERDLGKVLTGNDRWWENPEAGAAQPVHRAG,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D2:1]-[C;D2+:2]-[C;D2:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D2:3]
aries-halogenase-1f58dbec71994620de8a,1,MARSEESNTLARLFDVLGDDAAAAREWVTEPHRLIASNERLGTAPEAPADDDPEAIRTVGVIGGGTAGYLTALALKAKRPWLDVALVESADIPIIGVGEATVSYMVMFLHHYLGIDPAEFYQHVRPTWKLGIRFEWGSRPEGFVAPFDWGTGSVGLVGSLRETGNVNEATLQAMLMTEDRVPVYRGEGGHVSLMKYLPFAYHMDNARLVRYLTELATRRGVHHVDATVAEVRLDGPDHVGDLITTDGRRLHYDFYVDCTGFRSLLLEKALGIPFESYASSLFTDAAITGTLAHGGHLKPYTTATTMNAGWCWTIPTPESDHLGYVFSSAAIDPDDAAAEMARRFPGVTREALVRFRSGRHREAWRGNVIAVGNSYAFVEPLESSGLLMIATAVQILVSLLPSSRRDPLPSNVANQALAHRWDAIRWFLSIHYRFNGRLDTPFWKEARAETDISGIEPLLRLFSAGAPLTGRDSFARYLADGAAPLFYGLEGVDTLLLGQEVPARLLPPRESPEQWRARAAAARSLASRGLRQSEALDAYAADPCLNAELLSDSDSWAGERVAVRAGLR,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-1115fd804c8295496031,1,MIRSVVIVGGGTAGWMTASYLKAAFDDRIDVTLVESGNVRRIGVGEATFSTVRHFFDYLGLDEREWLPRCAGGYKLGIRFENWSEPGEYFYHPFERLRVVDGFNMAEWWLAVGDRRTSFSEACYLTHRLCEAKRAPRMLDGSLFASQVDESLGRSTLAEQRAQFPYAYHFDADEVARYLSEYAIARGVRHVVDDVQHVGQDERGWISGVHTKQHGEISGDLFVDCTGFRGLLINQTLGGRFQSFSDVLPNNRAVALRVPRENDEDMRPYTTATAMSAGWMWTIPLFKRDGNGYVYSDEFISPEEAERELRSTVAPGRDDLEANHIQMRIGRNERTWINNCVAVGLSAAFVEPLESTGIFFIQHAIEQLVKHFPGERWDPVLISAYNERMAHMVDGVKEFLVLHYKGAQREDTPYWKAAKTRAMPDGLARKLELSASHLLDEQTIYPYYHGFETYSWITMNLGLGIVPERPRPALLHMDPAPALAEFERLRREGDELIAALPSCYEYLASIQ,NC(=O)c1ccccc1N,NC(=O)c1ccccc1N,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-aa35818bff67437abfd1,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Nc1ccc2c(c1)CCCC2=O,Nc1ccc2c(c1)CCCC2=O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-8296f1f76b7d679cfb8d,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,c1ccc(Nc2nnc[nH]2)cc1,c1ccc(Nc2nnc[nH]2)cc1,[n;H;D2:1]>>[n;D2:1] || [n;D2:1]>>[n;H;D2:1] || [c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-a4aab274a57a4958eb0c,1,MDVHEIDETLEKFLAENYTPERVQQLADRFQRTGFVKFDSHMRIVPEELITAVRAEADRLVREHKERRDLVLGTTGGTPRNLSVVKSQDVEQSDLIRAVTRSEVLLTFLAGITRERIIPEVSDDERYLITHQEFASDTHGWHWGDYSFAFNWALRMPPIASGGMVQAVPHTHWDKNAPRINETLCERQIDTYGLVSGDLYLLRSDTTMHRTVPLTEDGAVRTMLVVSWSAERDLGKVLTGNDRWWENPEAGAAQPVHRAG,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D2:1]-[C;D2+:2]-[C;D2:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D2:3]
aries-halogenase-b3658670d2a52e2c9af9,1,MTQARIRKVVIAGGGTAGWVAAAALAHQFRGLLEIVLVESEQIGTIGVGESTVPPIRAFHRFLQIDEQEFLRAVAGTFKLAISFEDWQGQGDRYIHPFGSTGQGTLVCAFHHFWLEAQRRGMHSGFDEYCLEAQAARADRFAVLQQPAVNYAYHLDAGLYARFLRTHAQRYGATRIEGKIQQVRQHADSGFVEALVLEDGQVVEGDLFIDCTGFRGLLIEQTLHTGYEDWSHWLPCDRAVAVQTESVEPPVPYTRAIAHAAGWRWQIPLQHRVGNGLVYARAHLSDDEASAMLLAAVQGTPRRDPMLVPFVTGRRLQTWNKNVVALGLASGFVEPLESTSIHLAIVAVMRLITLFPADGIAQPQVDLFNRISRAEAEHVRDFVILHYHATQREEALWRQCRAMELPESLQLRLRAWREGAHAWQDGDELFRVDSWTHVLLGQRVAPAQHHPLTRALPDQHLQQLLDGIRQPLQHVVTQLPTQQAFIDSYCKVDQSTWG,O=Cc1ccc2[nH]ccc2c1,O=Cc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-fd36d80fe16f0daad18e,1,MSEVDFDIGIIGGGPAGSAIASYLAKAGLNCVIFEGDIFPREHVGESLIPATTPVLDDIGFLPQMETAGFPKKYGAAWTSASDQNIPTMGFEGMSHGFRAAEIEFHEREQLGVTQDYTYHVDRAKFDLMLLQHAASLGAKVYQGVRVRRVDFSETNPRIIFPIGKTETSVRVRMVVDASGRNTFLGRQLKLKVSDPVFNQYAVHTWFDNLDRTALSVNKEQADYIFIHFLPVTDTWVWQIPITDTITSIGVVTQKEQFKASKEDLDGFFWECVGSRPELKEALEKSDQVRPFKTEGDYSYAMKQIVGDQWATIGDAARFVDPIFSSGVSVALNSARLISGEIIAAAEQGDFRKEMFSNYEGKIRRAVSNWYEFISIYYRLNILFTAFVQDPRYRLDVLKMLQGDVYDDEEPKALAAMREITKQVEENPDHLWHKHLGSLRAPSAAPMF,O=C(S)c1ccc[nH]1,O=C(S)c1ccc[nH]1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-89c1baf80810ed35b8cc,1,MAKENVDVLIIGAGPAGTMTAAKLIQAGLTVKIVERSHFPRYVIGESLLPQSMQHLEDAGFMDALVARNYQKKIGANFKQDDFQEFFDFSKNYTDGWTWTWQVPRDDFDNVLAEEVQKMGAPIEFGTSVVDANMDLEEPIIKVVNEAGDVQEIQAKFVVDSSGYGRVLANLLDLNEPSSAPTRATLFAQFKPADGIETGAENNKVTILVHEEDVWVWLIPFSDGRVSVGFVGNPEYLESAQGDAKTRFLTYLARDQHASAMLEGMALCMEPKEIKGYSKGIKQLFGKNFVLTGNASEFIDPVFSAGVMFAIESGARAADLIVAQLNGEEADWQQDYEAHMLKGIAVMRTYIEGWYDGRLRRLFFSDNKPEKIKSQITSVLAGYVWDETNPFVNRSEKTLNLLSELHNNPEMA,O=C(S)/C=C/c1ccc(O)cc1,O=C(S)/C=C/c1ccc(O)cc1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-b45b7246ed2a1e2197de,1,MVKSIVVVGGGSAGWITANLLNAHCRRAGRQTQITLVESPDIPTIGVGEATVPSIRRTLSDIGLPEQELLISAEATFKTLIRYKNWNLGDSYDHPFDRRRRPLTDGAVRRWTAQNNLPFDRSFSALSQLADNHISPKSPRQPQYQGAFPYAYHLDAIKLANRLASFGRERGIQHKLCKVTDVKVSPEGLISAVHTDQGEALTADLYVDCTGFRAALLGGGLGVKMKSFAKHLLCNRAVTMRIPYEVYKPERIVTYTQAIARDHGWQWDINLQTRRGIGYVYSSDFLSEDAAETALRQNEGPHSDGLEARHIRFTSGKRLVSWKGNCVAVGLADGFLEPLESSGLYLVEFAGRAIATMLDDFATAPQATARYYNRIVDELYDEILGFLNLHYVTSKRRDTPFWQAVTADDAILDDLRDRLELWKRRSPTEFDFPGADRLFAQDSYEFILHGMKYVDGPVSGAPAVPDMSALISKSRSELPDHEAILALVQRAAAARA,CC1(C)c2[nH]c3ccccc3c2C[C@@]23CN4CCC[C@]4(C[C@@H]12)C(=O)N3,CC1(C)c2[nH]c3ccccc3c2C[C@@]23CN4CCC[C@]4(C[C@@H]12)C(=O)N3,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-60cafa03272449d4129f,1,MQHTYPAQLMRFGTAARAEHMTIAAAIHALDADEADAIVMDIVPDGERDAWWDDEGFSSSPFTKNAHHAGIVATSVTLGQLQREQGDKLVSKAAEYFGIACRVNDGLRTTRFVRLFSDALDAKPLTIGHDYEVEFLLATRRVYEPFEAPFNFAPHCGDVSYGRDTVNWPLKRSFPRQLSGFLTIQGADNDAGMVMWDNRPESRAALDEMHAEYRETGAIAALERAAKIMLKPQPGQLTLFQSKNLHAIERCTSTRRTMGLFLIHTEDGWRMFD,CC(C)C[C@H](NC(=O)CCC(=O)O)C(=O)O,CC(C)C[C@H](NC(=O)CCC(=O)O)C(=O)O,[C;D3:1]-[C;D2+:2]-[C;D3:3]>>[C;D3:1]-[C@@;D3+:2](-[Br;D1:4])-[C;D3:3]
aries-halogenase-4bf983753a3d8b68554e,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMVINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12,COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-20de50c5e5cbd4d4110a,1,MNKPIKNIVIVGGGTAGWMAASYLVRALQQQANITLIESAAIPRIGVGEATIPSLQKVFFDFLGIPEREWMPQVNGAFKAAIKFVNWRKSPDPSRDDHFYHLFGNVPNCDGVPLTHYWLRKREQGFQQPMEYACYPQPGALDGKLAPCLSDGTRQMSHAWHFDAHLVADFLKRWAVERGVNRVVDEVVDVRLNNRGYISNLLTKEGRTLEADLFIDCSGMRGLLINQALKEPFIDMSDYLLCDSAVASAVPNDDARDGVEPYTSSIAMNSGWTWKIPMLGRFGSGYVFSSHFTSRDQATADFLKLWGLSDNQPLNQIKFRVGRNKRAWVNNCVSIGLSSCFLEPLESTGIYFIYAALYQLVKHFPDTSFDPRLSDAFNAEIVHMFDDCRDFVQAHYFTTSRDDTPFWLANRHDLRLSDAIKEKVQRYKAGLPLTTTSFDDSTYYETFDYEFKNFALNGNYYCIFAGLGMLPDRSLPLLQHRPESIEKAEAMFASIRREAERLRTSLPTNYDYLRSLRDGDAGLSRGQRGPKLAAQESL,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-cf7dee3443a859943d9e,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-4c92b97852bfee902033,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVHTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,CCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CCC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-b45048bf83d0e17f9499,1,MTHLHSGLPQLPGKSGPRSTGICGATEQESPVLNNVVIVGGGTAGWMTASYFKAAFGERINITLVESGNIGAVGVGEATFSDIRHFFDFLGLKEKDWMPACNATYKLAVRFENWREEGHYFYHPFEQMRSVNGFPLADWWLREKPTDRFDKDCFVMPSIIDAGLSPRHLDGSLIDQPFVEGAEEMQGLTMSEHQGKTQFPYAYQFEAALLAKYLTTYSVERGVKHIVDDVQQVNLDERGWIRNVTTAEHGEIGGDLFIDCTGFRGLLLNKALEEPFISFQDTLPNDSAVALQVPMDMERRGILPCTTATAQDAGWIWTIPLMGRVGTGYVYAKDYISPEEAERTLREFVGPAAADAEANHIKMRVGRSENSWVKNCVAIGLSSGFVEPLESTGIFFIHHAIEQLAKNFPGEDWNPVQRNLYNDSVAHVMDGVREFLVLHYVAAKRSDTQYWRDTKTRKIPDALAERIEKWKTQLPDTETVFPYYHGLPPYSYHCVLLGMGGIDVKPSPALALGDSAAAEREFAEIREKTRHLTSVLPKAYDYFSRMR,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-390b199c873dd8377f30,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYRGNFEEEFRNPWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-f66939aed19dcd4556a2,1,MAEGQQNSGNSNGENIIPPEDVAKFLPKTVEEGGWEKCWEDGVTPWDQGRATPLVVHLVESSSLPLGRALVPGCGGGHDVVAMASPERYVVGLDISESALEKAAETYASSPKAKYFTFVKEDFFTWRPSELFDLIFDYVVFCAIEPEMRAAWAKTMYELLKPDGELITLMYPITDHDGGPPYKVAVSTYEDVLVPVGFKAVSIEENPYSIATRKGKEKLGRWKKIN,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,[S;+;D1+:1]-[C;D1:2]>>[S;D0+:1] || [c;D2:1]1:[n;D2:2]:[c;D3:3]2:[c;D3:4](:[c;D3:5]:[n;D2:6]:1):[n;D2:7]:[c;D2:8]:[n;D3:9]:2-[C;D3:10]>>[C;D2:1]1-[N;D2:2]-[C;D3:3]2=[C;D3:4](-[C;D3:5]-[N;D2:6]-1)-[N;D2:7]-[C;D2:8]-[N;D3:9]-2-[C;D3:10]
aries-halogenase-b8a137cb2c0a7f90827d,1,MDEIDDPRIRSVVIVGGGTAGWMTAAALVQHFRTAPLKITVVESSDIGTIGVGEATIPTIRRFYGQLGLRDDDVMRATQATCKLGIRFLDWSGPGSDFIHPFGLYGQDVKGIGFHHYWLKQRRAGDAAPLAAYSLGAALAAGGKFTLPSPHPPSQLSVFDWALHLDAGLFAQHLRAYAEAGGCARIDARIRSVELRPEDGFVRALTLDDGREVEGDLFVDCSGFKGLVIGEALGVGFEDWGRWLPCDAAYAVQSENRPGDAPAPFTRVTARSAGWQWGIPLRHRAGNGLVFSSAHLSDDQALAELMPHLLGDPLTEPRRIPFRPGRRSQAWAKNCVAIGLSSGFLEPLESTSIALIETGIERLKALFPDRRFAQPILDEFNDQTAREMERVRDFIILHYKLNRRTDTDFWRDCREMPVPETLERKIALWTARGQFVRYRWEMFHPASWLAIYDGFGLYPDHHDPAVDAMDPAYLARSLAEMRANIADLVARTPEHAQFLAGLDPAASAA,Brc1ccc2[nH]ccc2c1,Brc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-d191038eb3dacd219bba,1,MTTSERSSVSDFSPRRRSLLIGSASAAALATLGSTGTAAAAGAADEPPTVDFDFDNGNFIRDLIITRAGGVFPEEGVIGPMDASVYIWITSLFQLSWFDALAPYHPTAVGIHSRIARRPAGEAATNRNKNIAGLYAALRVLEGVFEERVPVMRAGFTAAGLDPDDRSEDPTTPIGIGNIAGKAVVRARANDGMNHLGNVGRKYHGKPYEDYTGYQPVNSPYKLVNPSKWQPALHPHQRRVGGGPGDKGIWVIQAFVTPQLALVKPYTYRNPGQFTVPVPDHSTHTNVRKYKQSVDQILEASATLTDEKKLMAEWFDNKLAGIALAPSAAALSHDLDLDGWCHLYAVTALARLDDLIAAWHWKTKFNSVRPFTAVHHVYGRKKISAWGGVGKGTVHDMPANEWSSYLPVGDHPEYISGSTTLCSAEAQAARRFLGDDVLDWTYSFPAGSGLTEPGLVPAKDTELHWDTWTRFTRDCADSRVWGGVHFQTTVDRSIEWGAQFGDRAHQFLQRHIKGEVS,CC(C)=CCC/C(C)=C/CC(Cc1c(O)cc(O)c2c(O)cc(O)cc12)=C(C)C,CC(C)=CCC/C(C)=C/CC(Cc1c(O)cc(O)c2c(O)cc(O)cc12)=C(C)C,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-bdf67436ad5405970b11,1,MNTRNPDKVVIVGGGTAGWMTASYLKKAFGERVSVTLVESGTIGTVGVGEATFSDIRHFFEFLDLREEEWMPACNATYKLAVRFQDWQRPGHHFYHPFEQMRSVDGFPLTDWWLQNGPTDRFDRDCFVMASLCDAGRSPRYLNGSLLQQEFDERAEEPAGLTMSEHQGKTQFPYAYHFEAALLAEFLSGYSKDRGVKHVVDEVLEVKLDDRGWISHVVTKEHGDIGGDLFVDCTGFRGVLLNQALGVPFVSYQDTLPNDSAVALQVPLDMEARGIPPYTRATAKEAGWIWTIPLIGRIGTGYVYAKDYCSPEEAERTLREFVGPEAADVEANHIRMRIGRSEQSWKNNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKHFPAGDWHPQLRAGYNSAVANVMDGVREFLVLHYLGAARNDTRYWKDTKTRAVPDALAERIERWKVQLPDSENVFPYYHGLPPYSYMAILLGTGAIGLRPSPALALADPAAAEKEFTAIRDRARFLVDTLPSQYEYFAAMGQRV,Nc1ccccc1C(=O)C[C@H](N)C(=O)O,Nc1ccccc1C(=O)C[C@H](N)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-a6ba1d32e2731f8c9a6a,1,MAIPQSCTVLVAGGGPGGSYTAAALAREGVDVVLLEADCHPRYHIGESLLPSMRYLLRFIDLEDTFEQHGFQKKLGAFFKLNAKSAGYTDFIRANGPNGYSWNVVRSESDEILFRHATKSGAKTFENVSLKSVNFEPYENDKFTSQDKLTNPGRPVSAEWKTKDGCSGTISFDYLVDATGRVGILSTKYLKNRKFNESFRNIAMWGYFKGNIPPSPGTDRENQPISEGMRDGSGWVWMLPLHNGTVSIGAVVRKDIFQAKKKALPEGTTEAQTLASLVALCPTISSYLEPAELASGIRQAADYSYSANAYAGPNFRIVGDAGCFIDPFFSSGHHLALSSALAAATSINACIRGDCNEFDASRWFAKKVDEGYTLFLVVVMAALKQIRMQEQPILSDLDEEGFDRAFTILRPVIQGAADKETAPKAKGESITETIDLCLTALNDLHDTELQRKLTSIVEAKGTPEQEQLLGKLSPDETAALHRMRAMHSILPMGELEDFENSNIDGFKARLEKGSLGLRRERALCRDHAGDLQM,COC1=CC(=O)C[C@@H](C)[C@]12Oc1cc(OC)cc(OC)c1C2=O,COC1=CC(=O)C[C@@H](C)[C@]12Oc1cc(OC)cc(OC)c1C2=O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-11b0147cac181f433e7f,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,Oc1ccc2cnccc2c1,Oc1ccc2cnccc2c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-bb76b704fd0dcf8ca008,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Oc1ccc(-n2cccc2)cc1,Oc1ccc(-n2cccc2)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-c91d793d0e481d8b9069,1,MSIPKSCEVLVAGGGPAGSYAASALAREGVDVVLLEADKHPRYHIGESMLPSIRPLLRFIDLEETFEKHGFQKKLGAAFKLTAKREGYTDFVAAHGPNGYSWNVVRSESDELLFKHAAKSGALTFQGVKVDSLEFEPYDSDFPSGGKVANPGRPVAARWSAKDGRSGTISFQYLVDATGRAGITSTKYLKNRKFNEGLKNLAIWGYYKGARPWAEGTPRENQPYFEGMRDGAGWCWTIPLHNGTVSVGAVLRSDLFFAKKKSLGEDVTNAMIMAECMKLCPTIKELLEPAELVSDIKQATDYSYSASAYAGPYFRIVGDAGCFIDPFFSSGHHLAMAGALAAAVSIRASMKGDCSEYEASNWHARKVDEGYTLFLLVVMAALKQIRMQEEPVLSDIDDDGFDRAFQFLKPVIQGSGSAEIVKRFTKKEVSEAIDFAVLALDNMAGAGEHANETNGSNGTGETNGDAKTLENITVEDEKVLSGIRILAKVAPSADMKDLEGTAIDGFMPRLEHGHLGLNRV,O=C1C[C@@H](c2ccccc2)Oc2cc(O)cc(O)c21,O=C1C[C@@H](c2ccccc2)Oc2cc(O)cc(O)c21,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-16a641c270b45a22f930,1,MSDFLYDVGIIGGGPAGSTMASYLAQAGLSCVVLEAEHFPRPHVGESLVPATTPVLREIGALEKVEKVGFPRKYGAAWTAAVDDSIPQLGFRGLHSGFRLADIRFSERDQPEVHQDHTYHVDRGRFDELLLEHASELGAVVRQGARVQRVDLDGESKRITYRDGSTEKSVRARMVVDASGRGTCLGRQLKLKEPDPVFNQYAIHTWFEDLDRQAVSGTEDRADYIFIHFLPLTDTWVWQIPITDTITSVGVVTQKSRFKEAAADDLEAFFWDSIDSRPELGRALRSARRLRSFKSEGDYSYAMRELCGDGWLLVGDAARFVDPIFSSGVSVALNSARLAARDIIAAHGAGDFTRQRFAAYEGKLRKAVRNWYEFISIYYRLNILFTAFVQDPRYRVDVLKMLQGDVYDAEEPAALGKMREVLREVESDPQHLWHRHLGSLRATAPATGV,Nc1ncnc2c1ncn2[C@@H]1O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]1O,Nc1ncnc2c1ncn2[C@@H]1O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]1O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-033581b0970477af916f,1,MKHGGMASGAIERVVIVGGGTAGWMAAAALGAYLAGAGTRITLIESSEIGTIGVGEATIPTIRRFYAALGMTDAEVMRACEATAKLGIRFVDWKPGTSFVHPFGRFGQDLRGIDFHQYWQKARQAGRAAPLEEYSLGAMLAREGHASVPLPNPPSQLSVFDWALHFDAARFAAHMRAYAERAGVARIDARITDVTLHGETGFIEAVTLDSGERVAGDLFVDCSGFRGLLIGEALGTPYRDWSHWLLCDGAFAVQSERVGEPPSCTTVTARTAGWQWRIPLRSREGNGLVFASDFQGDDEARAELLANIPGAPTMEPRRLRFTPGRREVAWARNCVSLGLASGFLEPLESTSIALIETGIERLKQLFPDKGFDPAVIAEYNAQSAEEMERVRDFILLHYHLSTRDGPFWQACREMTLPDSLAAKLELWRARGAFLRYRWEMFSPASWLAIYGGFEHLPERLDPGVAAVGTDELAQGLEQMRAAIARTVADTPTHSEFLATVDGAAAEPMRTSV,Cc1cc2ccccc2[nH]1,Cc1cc2ccccc2[nH]1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-00f7f5c26f42ca17edf8,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,O=C(Nc1ccccc1)c1ccc[nH]1,O=C(Nc1ccccc1)c1ccc[nH]1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-e0e6e0ac768fed60b145,1,MGIPADNLQSRAKASFDTRVAAAELALARGAVPSFANGEELLYRNSETGDPSFIGSFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIAALTLGPARDPETGLPIWRSDLANSLDLEVRGWENSSAGLTFDLEGPDAQSVAMPPAPVLTSPELIAEMAELYLMALGRDIEFSEFDSPKNAAFIRSAIERLNGLEWFNTPAKLGDPPAEIRRRRGEVTVGNLFRGILPGSEVGPYLSQFIIVGSKQIGSATVGNKTLVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLDVQDAADFRGFESYEPGARLIRTIRDLATWVHFDSLYEAYLNACLILLANGVPFDPNLPFQQEDKLDNQDVFVNFGSAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKNAFLKSESVFPEVDVLVEELSSILDDSASSNEKQNIADGDVSPGKSFLLPMAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDANFQIDQVFEVDTDEDKLVKSSFPGPLTVAGELNKLADNVAIGRNMAGVHYFSDQFESLLLGEQIAIGILEEQSLTYGENFFFNLPKFDGTTIQI,CC(C)=CCCC(C)=CCO,CC(C)=CCCC(C)=CCO,[C;D1+:1]-[C;D2+:2]=[C;D2+:3]-[C;D2:4].[C;D1+:5]=[C;D2+:6]-[C;D2:7]>>[C;D1+:1]=[C;D2+:2]-[C@@;D3+:3](-[C;D2:4])-[C;D2+:5]-[C@@;D3+:6](-[Br;D1:8])-[C;D2:7]
aries-halogenase-fe86430130c978b28368,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWAPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-3da8c7b2f0cdecf763dc,1,MSTHFLGKVKFDEARLAEDLSTLEVTEFSSAYSDFACGKWEACVLRNRTGMQEEDILESHNAPALATPLSKSLPYLNELVETHFDCSAVRYTRIVRVSENACIIPHTDYLELDETFTRLHLVLDTNSGCANTEEDKIFHMGLGEIWFLDAMLPHSAACFSKTPRLHLMIDFEATAFPESFLRNVEQPVTTRDMVDPRKELTDEVIEGILGFSIIISEANYREIVSILAKLHFFYKADCRSMYDWLKEICKRRGDPALIEKTASLERFFLGHRERGEVMTY,O=C(O)[C@@H]1CCCN1,O=C(O)[C@@H]1CCCN1,[C;D2:1]-[C;D2+:2]-[C;D3:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D3:3]
aries-halogenase-d79d5ca8d078fe269bc2,1,MSNNTISTKPALHFLDINATEVKKYPTAIQDIIINRSFDGMIIRGVFPRDTMEQVARCLEEGNDGGMKSILNKNEEFGTKVLQIYGHAIVGQSPDLKDYFASSAIFRQACRTMFQGSPDFEEQVESIFHSLSELPVEIPTGPEGQTYTPATIRLLLEGREIAVHVGNDFLLMPAANHLKTLLDLSDQLSYFIPLTVPEAGGELVVYSLEWNPQEASKYAQMQEYMDDVESKIKSNQSQSVAYAPGPGDMLLFNGGRYYHRVSEVIGNSPRRTIGGFLAFSKQRNKIYYWS,C=C(C)[C@H]1CCC(C)(C)C(=O)[C@@H]1c1c[nH]c2ccccc12,C=C(C)[C@H]1CCC(C)(C)C(=O)[C@@H]1c1c[nH]c2ccccc12,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-d6882ad218ce73f74cb4,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,c1ccc2c3c([nH]c2c1)CNCC3,c1ccc2c3c([nH]c2c1)CNCC3,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-058b346de9b51add4eca,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,N#Cc1ccc(Oc2cccc(N)c2)cc1,N#Cc1ccc(Oc2cccc(N)c2)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-c50281c3dd92d836d2ba,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,CN(C)CCN1CCCc2ccccc21,CN(C)CCN1CCCc2ccccc21,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-fcc687ca8d076689aa4a,1,MNQYDVIIIGSGIAGALTGAVLAKSGLNVLILDSAQHPRFSVGEAATPESGFLLRLLSKRFDIPEIAYLSHPDKIIQHVGSSACGIKLGFSFAWHQENAPSSPDHLVAPPLKVPEAHLFRQDIDYFALMIALKHGAESRQNIKIESISLNDDGVEVALSNAAPVKAAFIIDAAAQGSPLSRQLGLRTTEGLATDTCSFFTHMLNVKSYEDALAPLSRTRSPIELFKSTLHHIFEEGWLWVIPFNNHPQGTNQLCSIGFQFNNAKYRPTEAPEIEFRKLLKKYPAIGEHFKDAVNAREWIYAPRINYRSVQNVGDRFCLLPQATGFIDPLFSRGLITTFESILRLAPKVLDAARSNRWQREQFIEVERHCLNAVATNDQLVSCSYEAFSDFHLWNVWHRVWLSGSNLGSAFLQKLLHDLEHSGDARQFDAALEAVRFPGCLSLDSPAYESLFRQSCQVMQQAREQARPVAETANALHELIKEHEAELLPLGYSRISNRFILKV,CC(=O)c1c(O)cc(O)cc1O,CC(=O)c1c(O)cc(O)cc1O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-2725d2bcfac13cc02f04,1,MENSTQVLVIGGGPGGATTAGLLAREGISVTLMEKETFPRYHIGESLLPSCQPILELLGVREKVESRGYQRKRGAYFDWAGEKWDVTFGDPTDDRASSYQVLRSDFDQVLLEHARELGVTAFEGAEVQRLTFDGDRPRSAVWSQPGAGITNAEITFDHVIDASGRSGLMTTRHLRTRRYHEVFRNIAVWGYWKNATPLPAGPEGAIAICYVPDGWLWGIPLGDGQLSVGLVTHRDVFNSRRQNGESLESIYHAAIRESPVIENLLPSAELVSSLRAEQDYSYTSERFSGPGYFLVGDAACFLDPLLSTGVHLAMYSALLAAASLASVLRGEFGEEAARDLYDRSYRQAYLRLLVVVSNLYQQNQGKDSYFWEAQRLTLRDANPDEIKQAFVDVVSGIEDLRDAQATLDTAVEATGMAMAQWDGWHWNPSALNHSELTESEWKKALDGSQDIDSLAPGERELAAARARFFDTAMQRVLGPVPQGGQGLYVVTRPRLGLANLQ,O=c1cc(-c2ccccc2)oc2cc(O)cc(O)c12,O=c1cc(-c2ccccc2)oc2cc(O)cc(O)c12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-209b2564567502735c4c,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVFTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-28aba8137d93763f7f1c,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,Oc1ccc2ncccc2c1,Oc1ccc2ncccc2c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-8b29757eee9719468c0e,1,MTTSERSSSPRFRMGRRSLLFGGLGGASAVALGTVGQGSAVAAGRSQQPPQIEFDFDTDNYLTFLGPGDEDAGVSRNADIFGPMDVTTFLWLNHLTSIAAFDSVAPYHESAVGIYSRIGRRPSSESATNRNKNIAGLHAGWQVWQSVLGKRAEDIRLVLIAIGLDPDDQSEDPTSPVGIGNIAGKSVWEALKRDGMNFLGDEGGRHYNPRPWADYTGYQPVNTPFELTNPSRWQPQLHPHNGRRVGGGPGDTGIYVTQHMVTPQIRRVKPHIFDDPRAFDLAPPEFSNHHDRRAYKRSVDEILEASAGLTDEQKAIAEVMDNKVWGIGHSGVAIANKHDQNGELGIEGWAFWLLEHVLATFDPLIVAWHNKVKYDAVRPISAVRHVYGSRKVTAWGGPGMGTVDDIRADHWASYLPVGDHSEYPSGSTTLCAASAQAARRFFDSDVLDWRFTIPAGSTLTEPGITPANDLELYFPTWTDFNQKCANSRVWGGVHFRKTVERSLVLGEQFGDMAHDFVQRHINGEVSD,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-bbe814c133ff59125385,1,MIPAPLRNIVIVGGGTAGWMAAAAFARVLGPSFNVQLIESEQLGTIGVGEATVPHIKAFNNLLGIDEAEFVRQTQGSFKLGIEFVDWQRPGTSYIHGFGTQIGHPLGLLPFHQYWIKQQRRGKAQPLGAYTLNTVAATRGKFMTSAGDVPANSPLASIAYAYHFDASQYARFLRGYAEQRGVTRLEGLIEQVQLDAHTGSVQSVQLASGQVVSGDLFIDCSGFRGLLIEEALHTGYHDFTHWLPCDRALAVPCEKVGPPTPYTRSTARAAGWQWRIPLQHRTGNGYVYSSAHISDDEAAAALLANLDGTPLADPRPLRFTTGRRKQFWNRNVVALGLASGFLEPLESTSIHLIQSGISKLLELFPREGISPVLVQRYNDRLAFEFDRIRDFLVLHYHATERDDSAFWRHCRTMPITPELQTTLDLFRDSGRFYRNAEEMFAEISWVQVMVGQGILPQGYHPLVDQVPDTDAEGFLASVAQTISHCVDVMPTHQQFIDRYCRADPVR,N#Cc1ccc2[nH]ccc2c1,N#Cc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-256a1f649084b2fc635c,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,COC(=O)c1c(OC)ccc2[nH]ccc12,COC(=O)c1c(OC)ccc2[nH]ccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-fdba794336e0776e1285,1,MGIPADNLQSRAKASFDTRVAAAELALARGVVPSFANGEELLYRNCETGDPSFIASFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIADLTLGPARDPETGLPIWRSDLANSLELEVRGWENSSAGLTFDLEGPDAQSVAMPPAPVLMSPELIAEMAELYLMALGRDIEFSEFESPKNAAFIRSAIERLNGLEWFNTPAKLGDPPAEIRRRRGEVTVGNLFRGILPGSEVGPYLSQYIIVGSKQIGSATVGNKTFVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLDVQDGADFRGFESYEPGARLIRTIRDLATWVHFDALYEAYLNACLILLANGVPFDPNLPFQQEDKLDNHDVFVNFGSAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKKSFLAGSDIIFPEVSELVEELSSILDDVAESNEKQNRADGIVSPDKSFLLPMAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDANFQIDKVFEVDTDEDKLVKSSFKGTLTVAGELNKLADNVAIGRNMAGVHYFSDQFESLLLGEQIAIGILEEQSLTYGENFFFNLPKFDGTTIQI,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-ea7fe8b72eff2ae0ca6d,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVATNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-1900b07bf0e92e677244,1,MDTNIINHYDIIIIGGGIAGLSATRHLLLKMPELSGRIAVIEPRSERRDNLDEDYKVGESTVEVSAMFFAKELELQDYLIENHPPKFSLQFHWPRELSKTDTIEDYYSTWAVKNPDIQAFQLNRCKIERDLLKMVIAQGAVYYHGRVRNVDNLDNDDMKSIDVEILSEVESGADFKLQQSIERITLTTDYIVDASGRNFTVGSRTDNILKDPKHLFGLDNASTWVRVKNTERSLFDFKSQDVTCSWTYDTNHFFGPGYWIWMIPLERGSRDYSIGVSYHRDKIQPSQLNSLDKFMSFLEKNQKLLYNLIKSGEIVDFHRWPKLAHTSKTFFSKNNWCVIGDAAAIFDPFYSTGMVMIAMEIECLTEMLKFKLSNAANDYHRRVEAFDKLIRCVTQINNHLIKDHSNHLGNASIMSWRIYFESSTYFSILLPAYIGKYHLCPIFSDHFTTDHENGLALRNQLLATLDYANENSINIGFMDNHRGGQLLGDWSPTSSWDYDHALSLAKYGHKRLNLPKCLSWSNFYLSLIICKLYYRVYGIGALWNSSFFKSLSNTTYRFSKFYFLSKLHSFNMIGTPNNDYYDKIQKDFKSYNYNQNNIVDWKY,CCCCCC(=O)c1c(O)cc(O)cc1O,CCCCCC(=O)c1c(O)cc(O)cc1O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-3f7e05acc03b0893efd9,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFSLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSSYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,COc1ccc2[nH]c3c(c2c1)CCNC3,COc1ccc2[nH]c3c(c2c1)CCNC3,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-2ae8a105b8d7661ed6ff,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLEGSGIYFIYAAIHMLARHFPNKTFDKVLVDRFNREVEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFTGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-259748e36ea458367b47,1,MNDIPSHTTVLVIGGGPGGAYTSTVLARENVQVTLLEAAQFPRYHIGESMLPSINHFYEYIGAEEKLRGFGFAKKVGAAAKFKQNKREAYTNFIEHNPRNAAVNVVRSDLDELLLRHAQESGATVFEQTRVTEILFDEKAPRDDPKPIGANYVRGGRTGHITFDYLVDASGTKGLMSTKYLKNRDMNQTLHNIACWGYWLGADMYMPGTDRHNAPWFESLTDESGWVWFIPLHDGTVSVGFVMDMSISINKKAALREKNPEEYCLRVHYLDQLQYAPGTRKLLKDAILKSDDGEIGIKSASDFSYSADYYAGDHYRLVGDAAAFIDPFFSSGVHLAHIGGLSAAVSVCASIKKQCTEKEAAKYHDMRVSRSYTRFMMVVLSAYKQIRSQTGDYLSTPEEDNYDRAFDFYRPIILGTADVGAKITQDELEKALDFCAGVLFPNDPELRDSIGTRIGFDLLKASGPMTGYESHLAKINSGTEGIDEDDEKRLALTSALDAIAKDDIDGFTPNLTRGSLGLTKHAAAM,O=C1C[C@@H](c2ccc(O)cc2)Oc2cc(O)cc(O)c21,O=C1C[C@@H](c2ccc(O)cc2)Oc2cc(O)cc(O)c21,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-914302698973596f3cc6,1,MKISSLGLTALLAAFAPCLGYEEPPEPTQPLLSGNVCRVRDSLDFLDPVPRAKVTLLKRLAIAKDEISVGPTCHINNGDEENVPLFAGQYHKTLPHDKFGQVDEDAYKKLLECVFTSDINECEKVPSGAGRRGGAKLTNPLGGTAHQVTGADSDNVFITTPDSLLSERLAAQQAEVYWMALLRDIPFGEFAKNDYVRLAAENLQGLPAFKGLNIPRSEGGKIDPVTDLFRTTWPGVTTGPVVSQFMLSDFLIDSIKVTPKADPLTPGVDYMTAFQPWLDVQNGASKLETTFDEENPRFIRNGRDLATIALRDQLYTEAFRAALILFTEGALGGEVGPYAEAERQQGFATFGEPHILTAMASASSVTRHAWYAKWQVHRMLRPEAYGALVHNTLMRDVITPLPDSILRNTELLNRVEVHNQRMNPDGEKTFLLPMAAAQGSPTHPAYPSGHAINNGAYITALKAFLGYEAGQKCFPNPVVSNDEGTKRIKYKPSGREIVGECVNEKGKLVEGLTYEGELNKISANVLLGRSHIGVHWRMDGVYGALMGETSCVRRLQQELPGLPEAREVEGKKRRGDIPPATYKFRLYSGKILELYGRNLYKLDGKLCEGAFTGDDFCDPIDEDDYSSFDDIVEEHAQFSLHGHTEL,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-b43ec56948fb3f0ed9a8,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIHLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-c59a181ee3c055aeeed5,1,MFRRDLQRFERPVASPFLNRRAGNTMPLSWNRWIGTSKSARSRKQQRKSTRRKLMSENLETRNLLAANLFHNEAMPEDVNEDDQVTALDALTIINRMNREQAGESAGDVRRGQMTDVNNDGRNSALDALMVINRLNRDQGGPRDSGSPDAGSGNQDQTDSETSGDNSDVEGTNGDDPSTDGTTSGDQTDADSAIELTGDAVLDWNNLFNELTSNSEDYQNPGYASRAMAMLNVAIYDSVAIASGDSEIAFYEYDSSLTNSSGDVSSQAAASSAAYSVLSSLYSDQQETIDSFYGDVLATYSQDPETEAGLILGAEVNSTVIANRANDGSDSVVEYTYTDEIGSFHSDPLNPDVPVWGPGWGDVDTFAISDADAFTPESPPDLTSEEYAASYNEVKELGAVDSTTRTADQTEAGIFWAYDRDGLGTPLTLFNDILETVAVQEGNTFEENAALFAQASVAMADAGVVAWTTKFGEELWRPVTAIQEGDFDGNTLTEGDADWTALGAPDGGDDIVGFTPQFPTYISGHATFGGALFGTLQEFYGTDDISFTVASEELEILLDNPELQEAYGLNLDDAERTFSSFSEAMAENGRSRVYLGIHFDFDDLVGQEVGQSIAAAVASEFSVATPEDDSTGKGVDDGQLATMDRDDQPNRDGVDGSRQRNREPVARDTTQVPQQQTSSRDESNRRSEDDQRIAAIDQIFAENRLI,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-d19828eb64fa5dea8a93,1,MKSRSLLLLLLLVTARLAAGPNAIVIQTDFGTKDGAVAAMKGIAFGVSPGLPIFDLSQDNTPYNIWEAAYRLKQTATFWPAGTVFVSVVDPGVGTERSSIVLQTKSGHFFVGPDNGTWTLVAEELGVAAVRRIDETTNRRAGSEKSYTFHGRDIYAFVGARLAAGLIPYEQVGPLLEAKVVSLPYQKATREGAALLGTIPMIDFHYGNVWTNIPDTLFEALTPAPQFGETFTVTIFHDGKEVWRGPMPYARTFGEVPEGSPLLYLNSLLNVAFALNMGSFSETHGLSSGGAWTVRVERAK,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,[C;D1+:1]-[C;D2+:2]-[S;+;D3:3]>>[C;D1+:1]-[C;D2+:2]-[Cl;D1:4]
aries-halogenase-9c80d3de185ee8623264,1,MDVHEIDETLEKFLAENYTPERVQQLADRFQRTGFVKFDSHMRIVPEELITAVRAEADRLVREHKERRDLVLGTTGGTPRNLSVVKSQDVEQSDLIRAVTRSEVLLTFLAGITRERIIPEVSDDERYLITHQEFASDTHGWHWGDYSFAFIWALRMPPIASGGMVQAVPHTHWDKNAPRINETLCERQIDTYGLVSGDLYLLRSDTTMHRTVPLTEDGAVRTMLNMTWSAERDLGKVLTGNDRWWENPEAGAAQPVHRAG,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D2:1]-[C;D2+:2]-[C;D2:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D2:3]
aries-halogenase-ec447ac59d239b8c2a01,1,MNNPDALRKVCIVGGGTAGWIAAAVMAHHMKGRLFEIELVESDDIGTIGVGESTIPPFMELIAKLDIDEQDFVRQVQASFKLGIEFKDWFRKDESYFHPFGDVGQRVELSDFYQCWRKATLAGHDFPLQDFAPATVMAHAGRFMLPFKARNTPIAGASYALHVDAKRVAQFLRGHAEARGVKRTEGIVTDVALDARGFVSTLTLKDGRTIDADFFIDCSGFRALLIEKALGSGYTDWSNYLFCDRAIAAQTENVGPPRPYTLAEAQDAGWRWRIPLQHRTGNGHVYSSEFMSDEEATRILLEKVEGEVVAGPMVVPFRTGVREKIWHRNVLAIGLSSGFIEPLESTAIHLIYRGMDFFFRFLPDRHCDPALADEYNRRMVADYTEIRDFIVLHYCTTARDDTPFWRKCRDMDWPDSLKERVELFRSNGTLREGLDELFRSVSWFSVLEGMGIRPRTYHPLVDRIDEAMLYAGLDKAREQLAGFVRQLPTQQQFIDAHCRAEKVDLTRPVMAGV,Fc1ccc2[nH]ccc2c1,Fc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-43eb64f59e486941b18a,1,MDVPLMELSGRAPVVRLHDIEADMAAATDAIRSQLTGWGFMAAEVPGIGERVEAMMNEFAAACRATGPSLSDYAYDVVPQLAVGGTHGFFPYNSEIPRLANGVPDPKEFIHVSGAMIGDQPPGAGDVLRAFPAFGTRAAEVFDIAFRLISLFGEVVRGMMPPGTPELDLSHDATNLRVIHYRDVGDREVLAHEHSGIQMLGLQLPPSDQGLQYVLHDGTWVEPVIAGTDVVLCNIGRMLTSASDGRFRPSTHRVHTKPMPAGYERLSSVLFAYPQHKARQWKMVDGELMSLNATWGDFIDSRFQGLGKQS,O=P(O)(O)OC[C@H]1O[C@@H](n2cnc3c(O)ncnc32)C[C@@H]1O,O=P(O)(O)OC[C@H]1O[C@@H](n2cnc3c(O)ncnc32)C[C@@H]1O,[C;D3:1]-[C;D2+:2]-[C;D3:3]>>[C;D3:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D3:3]
aries-halogenase-21445af8f7acc5de30b1,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,c1ccc(Nc2nnc[nH]2)cc1,c1ccc(Nc2nnc[nH]2)cc1,[n;H;D2:1]>>[n;D2:1] || [n;D2:1]>>[n;H;D2:1] || [c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-90b303a74db7b55640ca,1,MNVEQIDENLAKFLAERYTPESVAQLADRFHRFGFVKFDAANRLVPDELQTAVREECDLLIEQHKERRNLLLSTTGNTPRRMSVVKSEEIEKSELISTLSRSEVLLGFLAGITREEIIPEVSSDERYLITHQEFKSDTHGWHWGDYSFALIWALRMPPIEHGGMLQAVPHTHWDKSNPRINQTLCEREINTHGLESGDLYLLRTDTTLHRTVPLSEDSTRTILNMTWAAKRDLEKDLVGNDRWWENPEAEAARAVDNA,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D2:1]-[C;D2+:2]-[C;D2:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D2:3]
aries-halogenase-29d9c129c3e755f6bd3f,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,COC(=O)c1c(OC)ccc2[nH]ccc12,COC(=O)c1c(OC)ccc2[nH]ccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-21b65e4555259f84b5df,1,MINSVLIVGGGTAGWMTAAYLSKAFDKNINITVVESKEVKKIGVGEATFSTVRHYFDYLGLNESEWLPECSGSYKLGIRFENWDGQGNHFYHPFERWEVVKGFPISEWWLSKKLKDQRFDYDTFLTPHLCEAKRSPRRLDGSLFAQSIDKSLGQSTLAEQRAQYPYAYHFDADGVASFLKRYAMNRGVKHIEDDVTHVEIDTNGNIGYLEAKIYGKLRADLYIDCTGFKGLLINKALNEPFISFSDVLKNNRAVALRVPRENENDIEPYTTARTMSNGWRWTIPLYKRNGYGYVYCNKYQSPEEAEMELRKSIPYENAECVANHIRMRIGRSNRSWVKNCVAIGLSSAFVEPLESTGIFFIQHGIEQLVRFFPRSSGNELLIEEYNTRVNRVVDGVKEFLLLHFSLAQRNDTLYWKEWKNVELPKELLKKITLAQDHLLDKETIYPFYHGFEEYSWNTMILGLCSGSLNNKPALSLMTSDEADEMLLQHYMKAENMVNNLPTCYEYLKHIHDLKNKN,c1ccc2[nH]ccc2c1,c1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-621c052f2f82898bee0f,1,MTTSGHSPAASAAPKIAFDFDNGNFIRDLITTNGGGGFPPAEAIAPGDTTIYTWITLLFQMSWFDALAPYHPTAVGVYSRIERRPAAESATNRNKNIAGLHASYQVVKAVFEERAPVMRMAMTAFGLDADDESEDPTTPVGIGNIAGKAVVAARLDDGMNHLGDLGRTYNGRPYADYTGYQPVNTAYELVDPSRWQPALGPHQRRVGGGPGDKGVFTVQQFVTPQLRLVKPITFKDPGEFELAAPEHLNHTDAAYQRSVDEVLRASAALTDEQKVKAEFFEHSPVSLTWAPRAAALAHDLDLDGWAHLFVTTALARFDNLIAVWHQKHAHDAVRPFSAIKHVYGSAPVTAWGGPGKGTVTDLPADEWTSYLPEGNHPEYPSAFTTLCAAQAQAARRLLGDDVLDWTHAFPAGSAQTEPGLVPAGDLKLTWETWTAFENDCADSRVWAGVAFKETVERSIPFGARFGDLAYEFVQRHIKGDVQH,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-4d0751953578aa574c07,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,COC(=O)c1c(OC)ccc2[nH]ccc12,COC(=O)c1c(OC)ccc2[nH]ccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-a3b4b1d0d06dec981f85,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVATNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,C=CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C=CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-d21cea57447c0fff302a,1,MAASEPSSRFVLQRRSLLAGAAAAATLLPLGNVGVATAAPSVRSSSGSTSEFDLDTGNFIQYLSKNADTSAVSEFIAPMDVTILIRYTCMAHNAWFDALAPYHPTAVGVYSDLGRRPASESETNRNKNIAALYSWRHVMESVVPAGMPTFRNLMNSFGLDPDDDSEDPTTPVGIGNLAGKAVVEARLRDGMNQLGDKGVRYHGKPYRDYTGYQPVNTAYELNDPSHWQPQLLEHGRRLGDGDGDMGMFMTQVFTTPQMRLVTPYTYKDPSGFSIPVPKHTDHTNEGLYKKVVDRVLAASAALTEEQKLKAEFFDNKFLGVGKSVLAAAETHDLDLDGWVQLLMVTGVALLDSLIACWHYKHEYNVVRPFSAIRHVYGTNTVTAWGGAGVGTVNDMPANEWASYLNVGNHPEYPSASTTVISAEAQAARRFLGSDVLDWTYTYSAGSSLVEPGITPANDYQLHWDTWTDFVQDSSSSRVWGGVHFAESAENSIGFGTQFGDRAHEFVQRHLDGNVSK,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-2e18e12a751bac813306,1,MSNNTVSTKPALHFLDINATEVKKYPTAIQDIIINRSFDGMIIRGVFPRDTMEQVARCLEEGNDGGMKSILNKNEEFGTKVAQIYGHAIVGQSPDLKDYFASSAIFRQACRTMFQGSPDFEEQVESIFHSLSELPVEIPTGPEGQTYTPATIRLLLEGREIAVHVGNDFLLMPAANHLKTLLDLSDQLSYFIPLTVPEAGGELVVYSLEWNPQEASKYAQMQEYMDDVESKIKSNQSQSVAYAPGPGDMLLFNGGRYYHRVSEVIGNSPRRTIGGFLAFSKQRDKIYYWS,C=CC(C)(C)c1[nH]c2cccc3c2c1[C@H]1[C@@H](C#N)[C@@](C)(C=C)CC[C@@H]1C3(C)C,C=CC(C)(C)c1[nH]c2cccc3c2c1[C@H]1[C@@H](C#N)[C@@](C)(C=C)CC[C@@H]1C3(C)C,[C;D2:1]-[C;D2+:2]-[C;D4:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D4:3]
aries-halogenase-b687b757bd658e9ae562,1,MTIDFTPVELPVVEEDAEYNWNYILFWNNVGLELNRVTHTFGALKAGPPLSPRALGMLQLAVHDAYFAIHPSAGFTTFLTPGAEDGAYRLPDPSYAKDARQAVAGAAIAMLSKLYMKPKVVPRSPISHNAYAQLQHVLDISVTKAPAACDPASSSFIFGKAVATAVFDLLFHKEGADQSGYSPKPGPFKFNDEPTHPVELIPVDANIPDGDKMPRRQYHAPYYGETAKRFGTQTEHMLADPPGIRCAGEVAEYDDAIREVYAMGGAPGLNTTKRTPHQTVQGMFWAYDGPKLIGTPPRLYNQIVRKIAVTYKKDNDLVNSEVNNADFARLLALVNVAMTDAGIFAWKEKWEFEFWRPLSGVRDDVLRDPEGKASTAAIHSGLASAPQLQNSDEAPFKPPFPAYPSGHATFGAAAFQMVRKYYNGRLGKWATTSRDTIAVEMFVSEELNGVSRDLSNPYDPKRPITDQPGIVPTRMPRRFSSCWEMMFENAVSRIFLGVHWRFDAAAGQDILIPTTKKDVYAVDDKGAALFKNVEDIRYKTKGTRKGHKGLLPIGGVPLGIEIANEIYNNKLSPTPPGEQPMPQPPQHQGPPRKKGELAEAKDEEQAPMMDVAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-472c3c13b550b7064153,1,MSPSFVILGGGTAGWITAHLLERAWPDATITVVESPEIGTIGVGEGSTPSLKRFFEIIGAAEADWMPRCGATYKAGIRFVDWSPAAPWRDYRHPFTTQIDVHTEDAFILNCRNRRLGHDVPVRPDDFLLNGVLSAKGLAPVAPPNFPFRIEYGYHFDAGLLGQYLRELAVTRGVVHRPATVTTVRRAENGDIAALVTDREETIAGDIFVDCSGFNGLLIERTLGVPFHSFKDNLFNDAAVVVPTEMTGRPPVETVATALSNGWCWSIPLRHRVGNGYVYARDCQSPDAAETELRRTLGVSDAVPARHLTFRVGQVARHWERNCVAVGLSQGFIEPLEATALHLVLGTVEQFIRHYRDGGCTDRHRAAFNTVAAERMDGVRDYIVAHYKLNTRTDTDYWRANAANEALSDPLLHILDRWFRRGDIAEELARQGQRSHFGTLSWHCLLAGYGAFPPVSEARRDDMDFYAARRVGAFLEGCSRNFAPA,C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]1O,C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]1O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-5571095d1776b5ebe162,1,MKHGGMASGAIERVVIVGGGTAGWMAAAALGAYLAGAGTRITLIESSEIGTIGVGEATIPTIRRFYAALGMTDAEVMRACEATAKLGIRFVDWKPGTSFVHPFGRFGQDLRGIDFHQYWQKARQAGRAAPLEEYSLGAMLAREGHASVPLPNPPSQLSVFDWALHFDAARFAAHMRAYAERAGVARIDARITDVTLHGETGFIEAVTLDSGERVAGDLFVDCSGFRGLLIGEALGTPYRDWSHWLLCDGAFAVQSERVGEPPSCTTVTARTAGWQWRIPLRSREGNGLVFASDFQGDDEARAELLANIPGAPTMEPRRLRFTPGRREVAWARNCVSLGLASGFLEPLESTSIALIETGIERLKQLFPDKGFDPAVIAEYNAQSAEEMERVRDFILLHYHLSTRDGPFWQACREMTLPDSLAAKLELWRARGAFLRYRWEMFSPASWLAIYGGFEHLPERLDPGVAAVGTDELAQGLEQMRAAIARTVADTPTHSEFLATVDGAAAEPMRTSV,Brc1ccc2[nH]ccc2c1,Brc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-bdc1cc5988510c331dcc,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFVADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-21b727dd2bb3899c46db,1,MNTRNPDKVVIVGGGTAGWMTASYLKKAFGERVSVTLVESGTIGTVGVGEATFSDIRHFFEFLDLREEEWMPACNATYKLAVRFQDWQRPGHHFYHPFEQMRSVDGFPLTDWWLQNGPTDRFDRDCFVMASLCDAGRSPRYLNGSLLQQEFDERAEEPAGLTMSEHQGKTQFPYAYHFEAALLAEFLSGYSKDRGVKHVVDEVLEVKLDDRGWISHVVTKEHGDIGGDLFVDCTGFRGVLLNQALGVPFVSYQDTLPNDSAVALQVPLDMEARGIPPYTRATAKEAGWIWTIPLIGRIGTGYVYAKDYCSPEEAERTLREFVGPEAADVEANHIRMRIGRSEQSWKNNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKHFPAGDWHPQLRAGYNSAVANVMDGVREFLVLHYLGAARNDTRYWKDTKTRAVPDALAERIERWKVQLPDSENVFPYYHGLPPYSYMAILLGTGAIGLRPSPALALADPAAAEKEFTAIRDRARFLVDTLPSQYEYFAAMGQRV,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-cd5f8e6d9cb5602345df,1,MVKSIVVVGGGSAGWITANLLNAHCRRAGRQTQITLVESPDIPTIGVGEATVPSIRRTLSDIGLPEQELLISAEATFKTLIRYKNWNLGDSYDHPFDRRRRPLTDGAVRRWTAQNNLPFDRSFSALSQLADNHISPKSPRQPQYQGAFPYAYHLDAIKLANRLASFGRERGIQHKLCKVTDVKVSPEGLISAVHTDQGEALTADLYVDCTGFRAALLGGGLGVKMKSFAKHLLCNRAVTMRIPYEVYKPERIVTYTQAIARDHGWQWDINLQTRRGIGYVYSSDFLSEDAAETALRQNEGPHSDGLEARHIRFTSGKRLVSWKGNCVAVGLADGFLEPLESSGLYLVEFAGRAIATMLDDFATAPQATARYYNRIVDELYDEILGFLNLHYVTSKRRDTPFWQAVTADDAILDDLRDRLELWKRRSPTEFDFPGADRLFAQDSYEFILHGMKYVDGPVSGAPAVPDMSALISKSRSELPDHEAILALVQRAAAARA,C[C@@H]1COCCN1c1cc(C2(S(C)(=O)=O)CC2)nc(-c2cccc3[nH]ccc23)n1,C[C@@H]1COCCN1c1cc(C2(S(C)(=O)=O)CC2)nc(-c2cccc3[nH]ccc23)n1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-a233f1dd105ff2a0a487,1,MNKPIKNIVIVGGGTAGWMAASYLVRALQQQANITLIESAAIPRIGVGEATIPSLQKVFFDFLGIPEREWMPQVNGAFKAAIKFVNWRKSPDPSRDDHFYHLFGNVPNCDGVPLTHYWLRKREQGFQQPMEYACYPQPGALDGKLAPCLSDGTRQMSHAWHFDAHLVADFLKRWAVERGVNRVVDEVVDVRLNNRGYISNLLTKEGRTLEADLFIDCSGMRGLLINQALKEPFIDMSDYLLCDSAVASAVPNDDARDGVEPYTSSIAMNSGWTWKIPMLGRFGSGYVFSSHFTSRDQATADFLKLWGLSDNQPLNQIKFRVGRNKRAWVNNCVSIGLSSCFLEPLESTGIYFIYAALYQLVKHFPDTSFDPRLSDAFNAEIVHMFDDCRDFVQAHYFTTSRDDTPFWLANRHDLRLSDAIKEKVQRYKAGLPLTTTSFDDSTYYETFDYEFKNFWLNGNYYCIFAGLGMLPDRSLPLLQHRPESIEKAEAMFASIRREAERLRTSLPTNYDYLRSLRDGDAGLSRGQRGPKLAAQESL,Cc1ccc2[nH]ccc2c1,Cc1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-3595dba096286be744d1,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,CC1NCCc2c1[nH]c1ccccc21,CC1NCCc2c1[nH]c1ccccc21,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-f3907a096c7c4b68d751,1,MSADPTQRPIIGFMSDLGTTDDSVAQCKGLMHSICPGVTVIDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTETRSVAVRIKQAAKGGARGQWAGSAGGFERAEGSYIYVAPNNGLLTTVLEEHGYIEAYEVSSTKVIPERPEPTFYSREMVAIPAAHLAAGFPLSEVGRPLEDSEIVRYQPPQVEISGDTLTGVVSAIDHPFGNVWTNIHRTHLEKAGIGYGKRIKIILDDVLPFEQTLVPTFADAGEIGGVAAYLNSRGYLSLARNAASLAYPFNLKAGLKVRVETN,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-5343f4c9e3a3d41e260b,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,Oc1ccc2cccnc2c1,Oc1ccc2cccnc2c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-5ca452a03e3d5c2d4ecf,1,MSDFDYDIGIIGGGPAGSTMASYLAKAGISAIVLESAEFPRPHVGESLVTATTPVLQEIGALAKVDAAGFPKKYGAAWTSAAKETVPEMGFTGMTQGFRLASVEFQERDQPGVDQAYTYHVDRGKYDQLLLQHAAELGARVRERTRVQDVEFTDDGVVLTAVGDEGTERLRVRMVVDASGRQTMLGRKKKLKVPDPVFNQYAIHAWFDGLDRKALADDPEQEDFIFIHFLPVSDTWVWQIPISETTTSVGVVTQKAKVKSSGQEREEFFWECLGTRPELRAALEKAERVREFKTEGDYSYGMKEVVGDRWALIGDAARFVDPIFSSGVSVAMNSARLLAKDIVSAVERDDFSKKSFGDYERVLRRGVSSWYEFISIYYRLNILFTAFVQDPRYRLDVLKMLQGDVYGEEEPKALTRMREIVRRVEENPDHLWHPYLGTLRAPAAAPLF,O=C(S)c1ccc[nH]1,O=C(S)c1ccc[nH]1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-8fe5f40fd0363af88531,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,N#Cc1ccc(Oc2cccc(N)c2)cc1,N#Cc1ccc(Oc2cccc(N)c2)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-fb5fa8f93a7d3f429b02,1,MNKTIAVIGAGLSGIAAVKQLTDGGHEVTCFEKAESFGGVFADKKIYDDLHLTISNYFMAYSDYVPNHQKLKFWSKKEYINYLGEYIQRFDIAKHIHYDHEVRRVEKQGDKWIVTCKSGGKEHSKEFDMVAVCSGHFQKPKLPDLPGLDMFDGEIEHSNDYRDKHKYTGKRVLCVGLGESSADITSEISEVARKCILSLRRYPAVAPRYMAFQEDPYFTIDTSWLTSRIVNKLPHKYHGGITKGIFNKYVNSRNDHVRIRGEWLKKSGPSHHQAVTKNERLFRPIADGKVMPNIGGIERFEKNSVVFKDGTREEVDAVVFCTGYQLSFPFLDVSISNMRDLFKQMFIPEMGHSLSFIGFVRPQQGGIPVIAEMQCRYLSKLASGEAQLPTLSEMHDVVKHDTKHWQTEYKITPHVASLVNYCHYMDSMAKLVGCMPQIPSLFKDPLLRVKLLHNPQFAAQYRLDGPNNMTHTAREFLLSFPNISSWPRIIHFEVALAAQKLLSRLRLDGLREISK,Oc1ccccc1-c1ccccc1O,Oc1ccccc1-c1ccccc1O,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-cead18006a4de84ec215,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,CC(=O)N1CCc2ccc(N)cc21,CC(=O)N1CCc2ccc(N)cc21,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-cf52b737154eecd5cdee,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATHPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNCWNNSSYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-b9defee8a4ecc2a4b072,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,Cc1cc(N)ccc1Oc1ccncc1,Cc1cc(N)ccc1Oc1ccncc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-d4c1e7b51c1914fdebfb,1,MTTTNGRRPIIAFMSDLGITDDSVAQCKGLMLSVCPDVTIVDICHTMQPWDVEEGARYIVDLPRLFPEGTVFATTTYPATGTTARSVALRIAHASKGGARGQWAGSGAGFERKEGSYIYIAPNNGLLTTVIKEHGYLEAYEVSSPEVIPEQPEPTFYSREMVALPSAHLAAGFPLEKVGRRLADDEIVRFERKDPELVADHDLVGYVTNIDHPFGNVWTNIHRTDLEKLGVGYGTKLRITLDGVLPFELPLSPTFADAGEIGAAVAYLSSRGYLALARNAASLAYPYNLKAGISVQVKVG,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,[C;D1+:1]-[C;D2+:2]-[S;+;D3:3]>>[C;D1+:1]-[C;D2+:2]-[Cl;D1:4]
aries-halogenase-f06436fba104193e1c43,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,CC(=O)NC1CNc2ccccc2C1,CC(=O)NC1CNc2ccccc2C1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-3c2ea00c905c2d6de929,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMVINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,CC(C)NCC(O)COc1cccc2[nH]ccc12,CC(C)NCC(O)COc1cccc2[nH]ccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-15ccf2dd2d4f3fbce5f3,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,Nc1ccc2ncccc2c1,Nc1ccc2ncccc2c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-2b8bf3b855a2dbb68ce1,1,MPSEYVPEATTVLVIGGGPAGSYASTLLAREGIDVVLLEAVKHPREHVGESMLPSMRHYLRFIDLESEYDARKFMHKPGAAFKFVHGQRECYTDFKILGPDRTTWNVFRAEADELMLRHAASQGVKIFEETRVESITFSESVDNSVSPESRPIAASWKNKSGQVGKISFNWLIDASGRQGIMSTKYMKNRIYREGLRNVAAYGYWKDVTVFEEGGPRSNAPWFECLTDREGWAWLIPLHNGTTSIGVVMHQDTSNRKKAEGPSGLEQHYLSQLKLAPGVQDLIGSKGSYVPGSVKSTADYSYHATEYSGDHYRIIGDAAAFVDPLFSSGVHVAMTGALSAASTILGSMKGQVTEVEAQAWHDAKIGICQTRFLLVVLSAYRQMQHVGNKALLDDVNASNFDAAFSLFRPIYQGEHDTSTSLTNEELSKMIEFTRNLFTPTTHQQYNEVKQRVGDLIALSGPVMPSDELDKVLDSDDSDAKAVLKRINSLKVLRNDTSPESFTSEAVNGYVVNLERGQLGLVRA,Cc1cc(O)cc(O)c1C(=O)O[C@@H]1C[C@]2(C)[C@H]3CC(C)(C)C[C@H]3C=C(CO)[C@]12O,Cc1cc(O)cc(O)c1C(=O)O[C@@H]1C[C@]2(C)[C@H]3CC(C)(C)C[C@H]3C=C(CO)[C@]12O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-9607bf9d54d419afa018,1,MEKYMRGSTQILVIGGGPAGSTAAGLLAKEGFQVTLLERDEFPRYHIGESILPSCRPILEMLGVWDKVEAHGFQPKGGAYFFWGPEEWEVRFNSLGDDGTNAWQVVRSEFDEILLRHAASLGVEVVENITVKELQFEGDRPVAALWAGTKDASVSGRIAFDYVIDASGRGGVFAAKHLKNRQYHEIFRNVGAWSYWKNVKPLDRGPDGAIAVISSEDGWFWNIPLHDGTTSVGLVTGRDIFNEKKNALGGIQEVYDKAISETPHLKRLLEGAEQVSGMKVEQDYSYTAESFCGPGYLLSGDAACFLDPLLSTGVHLATYSAMLASASISSVLRGEVSEKEAWEFYNTVYRHSYERLLVLVSVFYESYRGKEHHFYNAQKLTSDQREGLSIQDAFDRIVTGIADLDDAQDVYSRVHAHLNGAESGDPNPLANLNKVHEQKQAPMTPENAVAGLYLAFRPRLHLARTEGVHTP,COc1c2c(c(O)c3c(=O)c4cccc(O)c4oc13)-c1c(cc(CC(C)=O)c(C(=O)O)c1O)CC2,COc1c2c(c(O)c3c(=O)c4cccc(O)c4oc13)-c1c(cc(CC(C)=O)c(C(=O)O)c1O)CC2,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-33c22ac26695fd271e81,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Nc1ccc2nn[nH]c2c1,Nc1ccc2nn[nH]c2c1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-5502404569d83b543c7e,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,COc1ccc(CC(C)NCC(O)c2ccc(O)c(NC=O)c2)cc1,COc1ccc(CC(C)NCC(O)c2ccc(O)c(NC=O)c2)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-1180705d05bb5bbe13b4,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-5f72fd7c6698ae5b2cbd,1,MSTHFLGKVKFDEARLAEDLSTLEVAEFSSAYSDFACGKWEACVLRNRTGMQEEDIVVSHNAPALATPLSKSLPYLNELVETHFDCSAVRYTRIVRVSENACIIPHSGYLELDETFTRLHLVLDTNSGCANTEEDKIFHMGLGEIWFLDAMLPHSAACFSKTPRLHLMIDFEATAFPESFLRNVEQPVTTRDMVDPRKELTDEVIEGILGFSIIISEANYREIVSILAKLHFFYKADCRSMYDWLKEICKRRGDPALIEKTASLERFFLGHRERGEVMTY,O=C(O)[C@@H]1CCCN1,O=C(O)[C@@H]1CCCN1,[C;D2:1]-[C;D2+:2]-[C;D3:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D3:3]
aries-halogenase-88ca90719c4880e9c960,1,MSVEDFDVVVAGGGPSGSTVATLVAMQGHRVLLVEKEVFPRYQIGESLLPATVHGVCRMLGVTDELAGAGFPIKRGGTFRWGARPEPWTFHFGISARMSGATSHAYQVERARFDEILLNNAKSKGVVVREGCSATDVVEDGERVTGLKYTDADGNGREVSARFVIDASGNLSRLYSKVGGKRNYSEFFRSLALFGYFEGGKRLPAPVSGNILSVAFDSGWFWYIPLSDTLTSVGAVVRREDADKIQGDREKALNALIAECPLISEYLENATRVTTGKYGELRIRKDYSYQQESYWRPGMVLVGDAACFVDPVFSSGVHLATYSALLAARSINSILAGDLDEKTAFNEFEARYRREYGVFYEFLVSFYQMNVNEESYFWQAKKVTQNQSTDIESFVELIGGVSSGETALTAADRIAARSAEFAAAVDEMASGDGDNMVPMFKSTVVKQAMQEAGQVQMKALLGEDAEPEMPLFPGGLVTSPDGMKWLPYHPA,N[C@@H](Cc1ccc(O)cc1)C(=O)S,N[C@@H](Cc1ccc(O)cc1)C(=O)S,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-a79a343aec5804950af7,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Nc1ccc2[nH]cc(C[C@H](N)C(=O)O)c2c1,Nc1ccc2[nH]cc(C[C@H](N)C(=O)O)c2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-6a96ab0bd63cade31bec,1,MTRSKVAIIGGGPAGSVAGLTLHKLGHDVTIYERSAFPRYRVGESLLPGTMSILNRLGLQEKIDAQNYVKKPSATFLWGQDQAPWTFSFAAPKVAPWVFDHAVQVKREEFDKLLLDEARSRGITVHEETPVTDVDLSDPDRVVLTVRRGGESVTVESDFVIDAGGSGGPISRKLGVRQYDEFYRNFAVWSYFKLKDPFEGDLKGTTYSITFEDGWVWMIPIKDDLYSVGLVVDRSKSAEVREQGADAFYSSTLAKCAKAMDILGGAEQVDEVRIVQDWSYDTEVFSADRFFLCGDAACFTDPIFRRSVLFSQGVHLASQSAVSAAAAIDRITRHGDEKDAVHAWYNRTYREAYEQYHQFLASFYTFASFTEPDSEFWRKRRITESDDDRLTRKKWFESLAGNGPEDPSGTVASFRDRASTMIAIGRHQRPELSDDFSEAELNPARVRWISDLTKRLNSITRFKWTGGKAVLKQHYRVEPIGFRLEQREVLANGEGLDMAQYPMDDEARQIFQDLAEEEFGYKTLVKRLGAVGRQELSTQIVVRLMEAGLLTGYDAQGEKVFVQGRLHFGGVGVEYEV,CC(=O)C(Cl)C(=O)S,CC(=O)C(Cl)C(=O)S,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-44898b43f6d5ea1c2b39,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,Oc1ccc(-n2cccc2)cc1,Oc1ccc(-n2cccc2)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-8df93a86bb739d44608e,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,Nc1ccc2c(c1)NC(=O)CO2,Nc1ccc2c(c1)NC(=O)CO2,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-ad5393c506d4ea318f81,1,MSIPKSCEVLVAGGGPAGSYAASALAREGVDVVLLEADKHPRYHIGESMLPSIRPLLRFIDLEETFEKHGFQKKLGAAFKLTAKREGYTDFVAAHGPNGYSWNVVRSESDELLFKHAAKSGALTFQGVKVDSLEFEPYDSDFPSGGKVANPGRPVAARWSAKDGRSGTISFQYLVDATGRAGITSTKYLKNRKFNEGLKNLAIWGYYKGARPWAEGTPRENQPYFEGMRDGAGWCWTIPLHNGTVSVGAVLRSDLFFAKKKSLGEDVTNAMIMAECMKLCPTIKELLEPAELVSDIKQATDYSYSASAYAGPYFRIVGDAGCFIDPFFSSGHHLAMAGALAAAVSIRASMKGDCSEYEASNWHARKVDEGYTLFLLVVMAALKQIRMQEEPVLSDIDDDGFDRAFQFLKPVIQGSGSAEIVKRFTKKEVSEAIDFAVLALDNMAGAGEHANETNGSNGTGETNGDAKTLENITVEDEKVLSGIRILAKVAPSADMKDLEGTAIDGFMPRLEHGHLGLNRV,O=c1oc2cc(O)ccc2c2ccccc12,O=c1oc2cc(O)ccc2c2ccccc12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-6cf69ce9e7aca4e0f11b,1,MINSVLIVGGGTAGWMTAAYLSKAFDKNINITVVESKEVKKIGVGEATFSTVRHYFDYLGLNESEWLPECSGSYKLGIRFENWDGQGNHFYHPFERWEVVKGFPISEWWLSKKLKDQRFDYDTFLTPHLCEAKRSPRRLDGSLFAQSIDKSLGQSTLAEQRAQYPYAYHFDADGVASFLKRYAMNRGVKHIEDDVTHVEIDTNGNIGYLEAKIYGKLRADLYIDCTGFKGLLINKALNEPFISFSDVLKNNRAVALRVPRENENDIEPYTTARTMSNGWRWTIPLYKRNGYGYVYCNKYQSPEEAEMELRKSIPYENAECVANHIRMRIGRSNRSWVKNCVAIGLSSAFVEPLESTGIFFIQHGIEQLVRFFPRSSGNELLIEEYNTRVNRVVDGVKEFLLLHFSLAQRNDTLYWKEWKNVELPKELLKKITLAQDHLLDKETIYPFYHGFEEYSWNTMILGLCSGSLNNKPALSLMTSDEADEMLLQHYMKAENMVNNLPTCYEYLKHIHDLKNKN,OCCc1c[nH]c2ccccc12,OCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-0b3fe555ae8bd943feae,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,Oc1ccccc1,Oc1ccccc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-9f8917ad86101b4ad991,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNPWNNGSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-fce1eda2d2a507fea1c0,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,CC(C)NCC(O)COc1cccc2[nH]ccc12,CC(C)NCC(O)COc1cccc2[nH]ccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-c57e45c141c978f153ef,1,MKIESVAIVGGGSSGWMTAAALSKLCPQLEIALIEDPNIKTVGVGESTLGHFNKFLHLLDLKDEDWMPACNATYKNSIRFTNFREGKGEVFEYPFGPSLDVSFFSQTDGINTWGKLANKYPEDFPPETFARFVNSNTYLAEHNRLTRNKDNKIPNFNFDWDTAYHIDAELFGQYLKEKIALPNGVKHIQGKVTGYQKESPNNHNFKYIILDQETAIFADLYIDCTGFKSLLLGEFMGEAFSPFSKKLANDKAMATRIPYENREEEMHNVTDCHAMKNGWVWNIPLWNRIGTGYCYSSRFVSKDDAEAEFREHLGERGKDAKIFHIDIGHGKRTRAWVNNCVGIGLSYGFIEPLESTGLLTTHENIENLVYLINQRDGYVTQAERDGFNYTCDHQIDSFSDFVAMHYAYSMRTDTPYWKWCTQMCNYMPESMGPHRQKQSTWQDLSTDTIGLNTWHINHNGISFIIAGHGLRPQSYDKLSEVLLKRNNESDYYYEDIRKDWLKHYESMVEYVKTLPTHYEFLRDEIYGSAE,Oc1ccccc1-c1ccno1,Oc1ccccc1-c1ccno1,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-1b0da4a7db331fce8fdc,1,MAAVTEEFDVAVVGGGPAGSTFAALVAKQGHRVVVLEKENFPRYQIGESLLPSTIHGVCRLSGAADDLAKAGFPLKRGGTFRWGARPEPWTFAFSVSPRMAGPTSVAYQVERSKFDDILLKNARKQGADVREGCSVRGVIEEGERVRGLTYADADGNEREIRARYVVDASGNKSRLYNKVGGTREYSDFFRSLALFGYFENGKRMPEPNRFNILCVAFESGWFWYIPLSDTLTSVGAVVRREMAEKIQGDPEKALRALIDECPMIADYLSDATRVTEGQYGEIRVRKDYSYHHTTFTRPGMMLVGDAACFVDPVFSSGVHLATYSSLLAARSLNSVLEGKVDEDAAMKEFEARYRREYGVFYEFLVSFYEMHRDENSYFWQAKKVTANSEPELQSFVELIGGVSSGEQGLMNTDALSERLADNSEEFATAVEKFAANEDGSSVPLFSSSVVRNAMQEAGQVQMRALLGEDAEPETPMFPGGLVSSPDGLYWLPATTA,NC(C(=O)O)c1ccc(O)cc1,NC(C(=O)O)c1ccc(O)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-1d653df7edb962b6c409,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,CC(=O)N1CCc2ccc(N)cc21,CC(=O)N1CCc2ccc(N)cc21,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-b06cbb3cbf7184f545d6,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-f8c0a48792e2503ccaf0,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATHPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNCWNNSNYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-82572b951646e3f43158,1,MSTHFLGKVKFDEARLAEDLSTLEVAEFSSAYSDFACGKWEACVLRNRTGMQEEDILVSHNAPALATPLSKSLPYLNELVETHFDCSAVRYTRIVRVSENACIIPHSDYLELDETFTRLHLVLDTNSGCANTEEDKIFHMGLGEIWFLDAMLPHSAACFSKTPRLHLMIDFEATAFPESFLRNVEQPVTTRDMVDPRKELTDEVIEGILGFSIIISEANYREIVSILAKLHFFYKADCRSMYDWLKEICKRRGDPALIEKTASLERFFLGHRERGEVMTY,O=C(O)[C@@H]1CCCN1,O=C(O)[C@@H]1CCCN1,[C;D2:1]-[C;D2+:2]-[C;D3:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D3:3]
aries-halogenase-1e19e076f5ae57e24342,1,MDVHEIDETLEKFLAENYTPERVQQLADRFQRTGFVKFDSHMRIVPEELITAVRAEADRLVREHKERRDLVLGTTGGTPRNLSVVKSQDVEQSDLIRAVTRSEVLLTFLAGITRERIIPEVSDDERYLITHQEFASDTHGWHWGDYSFALIWALRMPPIASGGMVQAVPHTHWDKNAPRINETLCERQIDTYGLVSGDLYLLRSDTTMHRTVPLTEDGAVRTMLNVSWSAKRDLEKDLTGNDRWWENPEAGAAQPVHRAG,NCCCC[C@H](N)C(=O)O,NCCCC[C@H](N)C(=O)O,[C;D2:1]-[C;D2+:2]-[C;D2:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D2:3]
aries-halogenase-f57b0c6391fb054db263,1,MAIPQSCTVLVAGGGPGGSYTAAALAREGVDVVLLEADCHPRYHIGESLLPSMRYLLRFIDLEDTFEQHGFQKKLGAFFKLNAKSAGYTDFIRANGPNGYSWNVVRSESDEILFRHATKSGAKTFENVSLKSVNFEPYENDKFTSQDKLTNPGRPVSAEWKTKDGCSGTISFDYLVDATGRVGILSTKYLKNRKFNESFRNIAMWGYFKGNIPPSPGTDRENQPISEGMRDGSGWVWMLPLHNGTVSIGAVVRKDIFQAKKKALPEGTTEAQTLASLVALCPTISSYLEPAELASGIRQAADYSYSANAYAGPNFRIVGDAGCFIDPFFSSGHHLALSSALAAATSINACIRGDCNEFDASRWFAKKVDEGYTLFLVVVMAALKQIRMQEQPILSDLDEEGFDRAFTILRPVIQGAADKETAPKAKGESITETIDLCLTALNDLHDTELQRKLTSIVEAKGTPEQEQLLGKLSPDETAALHRMRAMHSILPMGELEDFENSNIDGFKARLEKGSLGLRRERALCRDHAGDLQM,CC(=O)N1CCc2ccc(N)cc21,CC(=O)N1CCc2ccc(N)cc21,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-197fadbf47ebfda17735,1,MSNNTVSTKPALHFLDINATEVKKYPTAIQDIIINRSFDGMIIRGVFPRDTMEQVARCLEEGNDGGMKSILNKNEEFGTKVAQIYGHAIVGQSPDLKDYFASSAIFRQACRTMFQGSPDFEEQVESIFHSLSELPVEIPTGPEGQTYTPATIRLLLEGREIAVHVGNDFLLMPAANHLKTLLDLSDQLSYFIPLTVPEAGGELVVYSLEWNPQEASKYAQMQEYMDDVESKIKSNQSQSVAYAPGPGDMLLFNGGRYYHRVSEVIGNSPRRTIGGFLAFSKQRDKIYYWS,C=CC(C)(C)c1[nH]c2cccc3c2c1[C@]1(O)[C@H](CC[C@](C)(C=C)[C@@H]1C#N)C3(C)C,C=CC(C)(C)c1[nH]c2cccc3c2c1[C@]1(O)[C@H](CC[C@](C)(C=C)[C@@H]1C#N)C3(C)C,[C;D2:1]-[C;D2+:2]-[C;D4:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D4:3]
aries-halogenase-2b084c9efd9150fb848e,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,CC(=O)NC1CNc2ccccc2C1,CC(=O)NC1CNc2ccccc2C1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-7385cae611099e13d376,1,MSIPKSCEVLVAGGGPAGSYAASALAREGVDVVLLEADKHPRYHIGESMLPSIRPLLRFIDLEETFEKHGFQKKLGAAFKLTAKREGYTDFVAAHGPNGYSWNVVRSESDELLFKHAAKSGALTFQGVKVDSLEFEPYDSDFPSGGKVANPGRPVAARWSAKDGRSGTISFQYLVDATGRAGITSTKYLKNRKFNEGLKNLAIWGYYKGARPWAEGTPRENQPYFEGMRDGAGWCWTIPLHNGTVSVGAVLRSDLFFAKKKSLGEDVTNAMIMAECMKLCPTIKELLEPAELVSDIKQATDYSYSASAYAGPYFRIVGDAGCFIDPFFSSGHHLAMAGALAAAVSIRASMKGDCSEYEASNWHARKVDEGYTLFLLVVMAALKQIRMQEEPVLSDIDDDGFDRAFQFLKPVIQGSGSAEIVKRFTKKEVSEAIDFAVLALDNMAGAGEHANETNGSNGTGETNGDAKTLENITVEDEKVLSGIRILAKVAPSADMKDLEGTAIDGFMPRLEHGHLGLNRV,Cc1cc(=O)oc2cc(O)ccc12,Cc1cc(=O)oc2cc(O)ccc12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-51283fa355970ea47c59,1,MNTRNPDKVVIVGGGTAGWMTASYLKKAFGERVSVTLVESGTIGTVGVGEATFSDIRHFFEFLDLREEEWMPACNATYKLAVRFQDWQRPGHHFYHPFEQMRSVDGFPLTDWWLQNGPTDRFDRDCFVMASLCDAGRSPRYLNGSLLQQEFDERAEEPAGLTMSEHQGKTQFPYAYHFEAALLAEFLSGYSKDRGVKHVVDEVLEVKLDDRGWISHVVTKEHGDIGGDLFVDCTGFRGVLLNQALGVPFVSYQDTLPNDSAVALQVPLDMEARGIPPYTRATAKEAGWIWTIPLIGRIGTGYVYAKDYCSPEEAERTLREFVGPEAADVEANHIRMRIGRSEQSWKNNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKHFPAGDWHPQLRAGYNSAVANVMDGVREFLVLHYLGAARNDTRYWKDTKTRAVPDALAERIERWKVQLPDSENVFPYYHGLPPYSYMAILLGTGAIGLRPSPALALADPAAAEKEFTAIRDRARFLVDTLPSQYEYFAAMGQRV,NC(=O)c1ccccc1N,NC(=O)c1ccccc1N,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-c34ae04b892e736bd3b5,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATHPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNSWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-ef1956ff4324600bc95a,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Nc1ccc2c(c1)NC(=O)CO2,Nc1ccc2c(c1)NC(=O)CO2,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-8bba5b9b846fd63c473e,1,MSSLLPPHAQILVVGGGPAGSYCASILAREGFSVVVLEATTFPRYHIGESMLPSVRPFLKFSGADNKIASHGFCPKPGAAVKFQQHKREGYTDFSTLSSGNSPDNAAAWNVKRSEFDEILLRHAEELGAQVFENHRVINLIFADNNVSEGRPISAEFSCPNGELRSISFDYLVDASGRAGIMSTKYLKNRKFNNTLRNVASWGYWTGAKRYMPGSERDNAPFFEALTDGSGWAWFIPLHDSTVSVGIVTDQASSTARKALSARNGMHCSSKADYLAQLKLAPTVSGKFLCKATLQGENSPTCIRSASDFSYAADRYSGDHFRLIGDASAFIDPFFSSGVHLALLGALTAAASISASIRKTCSELRAAQFHDKKVAIAYTRFLLVVMGVYKQIRNQDLHILAEVDEDNFDRAFDILRPVIQGTADVGKTVSEDELQKTMDFCKDIFAPTDPQMHEAVGARLGPELCSPSVPIMTDSEIEDLTKDDNEAKLVLKEINARKAVHTMYGGPIHVAAESIDGLVLNLEVGNFGLKNVH,Cc1cc(O)cc(O)c1C(=O)O[C@@H]1C[C@]2(C)[C@H]3CC(C)(C)C[C@H]3C=C(CO)[C@]12O,Cc1cc(O)cc(O)c1C(=O)O[C@@H]1C[C@]2(C)[C@H]3CC(C)(C)C[C@H]3C=C(CO)[C@]12O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-4681639741f445ef1930,1,MEPQFDVGIIGGGPAGSTTASYLARAGLKVALFESDNFPREHVGESLVPATTPVLVDIDAFDKVEAAGFPKKFGAAWTSADSGPSDKMGFTGLDHDFRAAEIMFNERTQSGVHKDYTFHVDRGQFDLLLLKHAEEQGAKVHQGVRVNRVNFDGAFPVLETSVAGQRAKVPVKMVVDASGRRTQLGSQLKVKEKDPVFNQYAIHTWFDNFDRKALAVDQSQSDFIFIHFLPVIDTWVWQIPITDTITSVGVVTQKERLKASKDDLEKFFWDTLGSRPELHKALKESEQVRPLKTEGDYSYALTKVCGDNFLMVGDAARFVDPIFSSGVSVALNSARIASADIIAAHRAGDYSKKRFDTYESMLRRGVNNWYEFISIYYRLNILFTAFVQDPRYRIDVLKMLQGDVYDDEEPKALAAMREIVKAVEEDPNHLWHPFLGSLKAPSAKAMF,O=C(S)c1ccc[nH]1,O=C(S)c1ccc[nH]1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-b92f859368bbc325fe47,1,MKIESVAIVGGGSSGWMTAAALSKLCPQLEIALIEDPNIKTVGVGESTLGHFNKFLHLLDLKDEDWMPACNATYKNSIRFTNFREGKGEVFEYPFGPSLDVSFFSQTDGINTWGKLANKYPEDFPPETFARFVNSNTYLAEHNRLTRNKDNKIPNFNFDWDTAYHIDAELFGQYLKEKIALPNGVKHIQGKVTGYQKESPNNHNFKYIILDQETAIFADLYIDCTGFKSLLLGEFMGEAFSPFSKKLANDKAMATRIPYENREEEMHNVTDCHAMKNGWVWNIPLWNRIGTGYCYSSRFVSKDDAEAEFREHLGERGKDAKIFHIDIGHGKRTRAWVNNCVGIGLSYGFIEPLESTGLLTTHENIENLVYLINQRDGYVTQAERDGFNYTCDHQIDSFSDFVAMHYAYSMRTDTPYWKWCTQMCNYMPESMGPHRQKQSTWQDLSTDTIGLNTWHINHNGISFIIAGHGLRPQSYDKLSEVLLKRNNESDYYYEDIRKDWLKHYESMVEYVKTLPTHYEFLRDEIYGSAE,Nc1cccc2cccnc12,Nc1cccc2cccnc12,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-e6ac4ef9f6171a647367,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,CNCCc1c[nH]c2ccccc12,CNCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-56a5ec9c037f29456ae0,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNPWNNGSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-95d41ec85b213287fa1c,1,MEHYTHIPFDWARRNAAFDVRLRTAVQSREASYSGDDGHVTNGDEARFPTTLLGTFTKGLPHSLPLALPTDRSAFDAFVSGVNTGDLDTIKSIPLGPDPEGDNSFSSSAMTTGAKVRGWESMAAGLAFTLEAPDPQRVTMPPAPQIDSVELGYELSESYWMALCRDIAFTEFDNSDTVAEAAASMAAHAWVAEDGCDQLGELTPTQTAHRELEMKNGEGITQGTIFRGSLNGDNIGPYLSQFLLIGCDTLGSRFSNDDPESYLTGHIRFGAHRIDQRVRKAVPDRDYMTTWGAYIDVANGADVRGRESYVTAEGDNFNDEETHRFIHTPRDLATYVHYDALYQPYFNACLLMLAMGIGYDEGLPFGDEDEVDKQTGFALFGGPHILSLLAEVVLKALKAVRFQKFAMHRRARPETVAGWIDCVQRPRTSDEQEGNEGQTVFKPIEKLCQYVDSDLLQKVREHNVTQNNTQMDRDITRLHDYDPVDAVADCAVDQQQQVYEQQQTEDEQNEQQQQQRGGTYLLPMAYAEGSPMHPAYGAGHATVAGACTTILKAFFDTTQKLPYVFTSTDDGTKLVQIDVDEQLTVEGELNKLCSNISIGRNWAGVHWKSDYTESIKLGEEIAIGLLREQKNVYTECFSMTIPLFDGTCVTI,C#C/C=C/C[C@@H](O)[C@H](O)C/C=C\C/C=C/CC,C#C/C=C/C[C@@H](O)[C@H](O)C/C=C\C/C=C/CC,[C;D2:1]-[C@;D3+:2](-[C;D3:3]-[O;D1:4])-[O;D1+:5].[C;D2:6]-[C;D2+:7]=[C;D2+:8]-[C;D2:9]>>[C;D2:1]-[C@@;D3+:2](-[C;D3:3]-[O;D1:4])-[O;D2+:5]-[C@;D3+:8](-[C;D2:9])-[C@@;D3+:7](-[Br;D1:10])-[C;D2:6]
aries-halogenase-d308ddc557e774187ad6,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,COc1ccc(N)cc1N1CCCC1=O,COc1ccc(N)cc1N1CCCC1=O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-02c0b7bcc4d2aa75332f,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYRGNFEEEFRNPWNNGSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-e316e58e56a661b2d532,1,MSNNTISTKPALHFLDINATEVKKYPTAIQDIIINRSFDGMIIRGVFPRDTMEQVARCLEEGNDGGMKSILNKREEFGTKTMQIYGHVIPGQLPDLKDYFASAAIFRQACRTMFQGSPDFEEQVESIFHSLSELPVEIPTGPEGQTYTPATIRLLLEGREIAVHVGNDFLLMPAANHLKTLLDLSDQLSYFIPLTVPEAGGELVVYSLEWNPQEASKYAQMQEYMDDVESKIKSNQSQSVAYAPGPGDMLLFNGGRYYHRVSEVIGNSPRRTIGGFLAFSKQRNKIYYWS,C=C(C)[C@H]1CCC(C)(C)C(=O)[C@@H]1c1c[nH]c2ccccc12,C=C(C)[C@H]1CCC(C)(C)C(=O)[C@@H]1c1c[nH]c2ccccc12,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-b563622dd5a266e6a022,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,CC(=O)NC1CNc2ccccc2C1,CC(=O)NC1CNc2ccccc2C1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-6334610e2b0395f327c5,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,Oc1cccc2ncccc12,Oc1cccc2ncccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-cf7dd1665f80520a6a84,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATMPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-f3058bcbb026a6921bf1,1,MPIEEFDVVVAGGGPAGSTVASLVAMQGHRVLLLEKEVFPRYQIGESLLPATVHGVCRLLGVADELAAAGFPIKRGGTFRWGARPEPWTFSFGVSPRMSGPTSFAYQVERARFDQILLNNAKRKGVEVREGCPVTGVVEGEGRVAGLRYTDPAGREREVLARFVVDASGNKSRLHSSVGGTRNYSEFFRSLALFGYFENGKRLPEPYSGNILSVAFDSGWFWYIPLSDTMTSVGAVVRREMAEKIQGDQEKALRALIAECPLISEYLEDARRITTGRYGELRVRKDYSYYQTTFWRPGMILVGDAACFVDPVFSSGVHLATYSALLAARSINSVLADDLDEKTALTEFEARYRREYGVFYEFLVSFYEMNVNEESYFWTAKKVTNSGHTDLESFVELIGGVSSREAALTASARIAERSAEFSAAVDRMATSDDGNMVPLFKSQVVKQVMQESGQVQMKAVLGAGAEPELPLFPGGLVVSPDGMRWLPFRPGNGS,N[C@@H](Cc1ccc(O)cc1)C(=O)S,N[C@@H](Cc1ccc(O)cc1)C(=O)S,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-284c8d9831e1ac59c0cb,1,MSNNTVSTKPALHFLDINATEVKKYPTAIQDIIINRSFDGMIIRGVFPRDTMEQVARCLEEGNDGGMKSILNKNEEFGTKVAQIYGHAIVGQSPDLKDYFASSAIFRQACRTMFQGSPDFEEQVESIFHSLSELPVEIPTGPEGQTYTPATIRLLLEGREIAVHVGNDFLLMPAANHLKTLLDLSDQLSYFIPLTVPEAGGELVVYSLEWNPQEASKYAQMQEYMDDVESKIKSNQSQSVAYAPGPGDMLLFNGGRYYHRVSEVIGNSPRRTIGGFLAFSKQRDKIYYWS,C=C[C@@]1(C)CC[C@H]2[C@@H](c3c[nH]c4cccc(c34)C2(C)C)[C@H]1C#N,C=C[C@@]1(C)CC[C@H]2[C@@H](c3c[nH]c4cccc(c34)C2(C)C)[C@H]1C#N,[C;D2:1]-[C;D2+:2]-[C;D4:3]>>[C;D2:1]-[C@@;D3+:2](-[Cl;D1:4])-[C;D4:3]
aries-halogenase-cd52c325c5f219df1337,1,MTASYLKAAFGDRIDITLVESGHIGAVGVGEATFSDIRHFFEFLGLKEKDWMPACNATYKLAVRFENWREKGHYFYHPFEQMRSVNGFPLTDWWLKQGPTDRFDKDCFVMASVIDAGLSPRHQDGTLIDQPFDEGADEMQGLTMSEHQGKTQFPYAYQFEAALLAKYLTKYSVERGVKHIVDDVREVSLDDRGWITGVRTGEHGDLTGDLFIDCTGFRGLLLNQALEEPFISYQDTLPNDSAVALQVPMDMERRGILPCTTATAQDAGWIWTIPLTGRVGTGYVYAKDYLSPEEAERTLREFVGPAAADVEANHIRMRIGRSRNSWVKNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKNFPAADWNSMHRDLYNSAVSHVMDGVREFLVLHYVAAKRNDTQYWRDTKTRKIPDSLAERIEKWKVQLPDSETVYPYYHGLPPYSYMCILLGMGGIELKPSPALALADGGAAQREFEQIRNKTQRLTEVLPKAYDYFTQLR,N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O,N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-ae06d7e47d6ca2a5bcd7,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVATNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-edbb15588efba3a53712,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATHPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNCWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-50adb203dbbb09e50b32,1,MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVFTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,CC[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[Cl;D1:3]
aries-halogenase-fd1abbda17f4974a8fdc,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFVADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKTPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-2f71963a50636a5f9249,1,MIRSVVIVGGGTAGWMTASYLKAAFDDRIDVTLVESGNVRRIGVGEATFSTVRHFFDYLGLDEREWLPRCAGGYKLGIRFENWSEPGEYFYHPFERLRVVDGFNMAEWWLAVGDRRTSFSEACYLTHRLCEAKRAPRMLDGSLFASQVDESLGRSTLAEQRAQFPYAYHFDADEVARYLSEYAIARGVRHVVDDVQHVGQDERGWISGVHTKQHGEISGDLFVDCTGFRGLLINQTLGGRFQSFSDVLPNNRAVALRVPRENDEDMRPYTTATAMSAGWMWTIPLFKRDGNGYVYSDEFISPEEAERELRSTVAPGRDDLEANHIQMRIGRNERTWINNCVAVGLSAAFVEPLESTGIFFIQHAIEQLVKHFPGERWDPVLISAYNERMAHMVDGVKEFLVLHYKGAQREDTPYWKAAKTRAMPDGLARKLELSASHLLDEQTIYPYYHGFETYSWITMNLGLGIVPERPRPALLHMDPAPALAEFERLRREGDELIAALPSCYEYLASIQ,O=C(O)c1ccccc1Nc1ccccc1,O=C(O)c1ccccc1Nc1ccccc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-93f5dbaef3e7902247ef,1,MTASYLKAAFGDRIDITLVESGHIGAVGVGEATFSDIRHFFEFLGLKEKDWMPACNATYKLAVRFENWREKGHYFYHPFEQMRSVNGFPLTDWWLKQGPTDRFDKDCFVMASVIDAGLSPRHQDGTLIDQPFDEGADEMQGLTMSEHQGKTQFPYAYQFEAALLAKYLTKYSVERGVKHIVDDVREVSLDDRGWITGVRTGEHGDLTGDLFIDCTGFRGLLLNQALEEPFISYQDTLPNDSAVALQVPMDMERRGILPCTTATAQDAGWIWTIPLTGRVGTGYVYAKDYLSPEEAERTLREFVGPAAADVEANHIRMRIGRSRNSWVKNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKNFPAADWNSMHRDLYNSAVSHVMDGVREFLVLHYVAAKRNDTQYWRDTKTRKIPDSLAERIEKWKVQLPDSETVYPYYHGLPPYSYMCILLGMGGIELKPSPALALADGGAAQREFEQIRNKTQRLTEVLPKAYDYFTQLR,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-1dde21d9dfbe48a35ea7,1,MTTSGHTSVTGSSIGRRSLLVGSASAMALSQLVFARTAGAASEEPPELPDLDKDNYVKWAQPGDDQAGKSPSLQFIGPMDATVFLWTNRAAMLAAFDALAPYHETAVGIHSRIPRRPSSESTTNRNMNIAVIYAQHGIWKRLLPDNLGALRQLMTALGLNPDDESENLTSPIGIGNVAAKSVWKFLERDGMNVLGDEGGRRYNRQPWADYTGYVPVNTPYKVNNPSRWQPLLGPHNGRRLGGGPGDLGIYVGQAFVTPQAGRTTPHIFKHASRFPIARPDHTDHTDPRTYKRTVDDLLEASASLTDERKVLAEIYDNKLWGIGHSSIVIARSRDQDNHMGVHGWAQWVLQSILATFDTLIAGWYLKAKYDTVRPITAVRHVYGNKKITAWGGPGMGTVDDIPANEWTSYLTHSDHPEYPSGSTTLCAAGSQNTRRFFGDDVLDWTFTFPAGTSLSEPGVTPAKDVEVHFSTWTEFDKLCGRSRVDGGVHFTKTVERSIKWGEQFGDLTHEFVQRQVRGEVKD,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-3f5bc363a67d01e09fc6,1,MGIPADNLQSRAKASFDTRVAAAELALNRGVVPSFANGEELLYRNPDPDNTDPSFIASFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIADLTLGPARDPETGLPIWRSDLANSLELEVRGWENSSAGLTFDLEGPDAQSIAMPPAPVLTSPELVAEIAELYLMALGREIEFSEFDSPKNAEYIQFAIDQLNGLEWFNTPAKLGDPPAEIRRRRGEVTVGNLFRGILPGSEVGPYLSQYIIVGSKQIGSATVGNKTLVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLDVQDAADFRGFESYEPGARLIRTIRDLATWVHFDALYEAYLNACLILLANGVPFDPNLPFQQEDKLDNQDVFVNFGSAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKIAPQKGESIFPEVDLAVEELGDILEKAEISNRKQNIADGDPDPDPSFLLPMAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDSGIEIDQVFEVDKDEDKLVKSSFKGTLTVAGELNKLADNIAIGRNMAGVHYFSDQFESLLLGEQVAIGILEEQSLTYGENFFFNLPKFDGTTIQI,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-31c784955084f7758276,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,COc1ccc2c3c([nH]c2c1)C(C)NCC3,COc1ccc2c3c([nH]c2c1)C(C)NCC3,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-fa4c5b840101cf9fd230,1,MDNRIENVLVLGGGTAGWMTAAYLGKALGETVTVTVLEAPGIPRIGVGEATVPNLQRVFFDFLGIDEDDWMRECNASFKTAVRFVNWRTPGRGEAEARDLEGRPDHFFHPFGLLPTHDGVPLSHYWARDRLRGVTEEPFDYACFREPPMMDALRAPKWFDGTPATRYAWHFDAQLVAEYLRRFAIERLGVRHVEDEMTEAEIDERGFITRLRTRSGRTLAADLFVDCSGFRGLLINKALDEPFLDMSDQLLCDSAVATAIPHDDEARGVEPYTSAIAMSSGWSWKIPMPGRFGTGYVYSARHTDKDDATEEFSRMWGLDPERTAFNHIRFRVGRNRRAWVNNCVSVGLSSCFLEPLESTGIYFITAALYQLAKHFPDRRFDPVLVDRFNREIELMFDDTRDFIQAHFYLSPRVDTEFWADNKKLTLPENIQEKIAMFRSGLPINEPVTDEATYYGNFDAEFRNFWTNGSYYAIFAGLGHTPDRVLPALNYRPETDAGHLFDEVRKRQRDIVETLPSNHEFLVKLHGR,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-5ff4e7aa9198d741e51b,1,MTTFTTRDGTQIYYKDWGSGQPIVFSHGWPLNADSWESQMIFLAAQGYRVIAHDRRGHGRSSQPWSGNDMDTYADDLAQLIEHLDLRDAVLFGFSTGGGEVARYIGRHGTARVAKAGLISAVPPLMLKTEANPGGLPMEVFDGIRQASLADRSQLYKDLASGPFFGFNQPGAKSSAGMVDWFWLQGMAAGHKNAYDCIKAFSETDFTEDLKKIDVPTLVVHGDADQVVPIEASGIASAALVKGSTLKIYSGAPHGLTDTHKDQLNADLLAFIKG,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-8595f9e3f5f0a6e7df8f,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACADAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-015dd044ee9f809cdf83,1,MTTSGHTSFSDYSPRRRSMLLGGLGGAAALSAAGFTGMASASPRGSAGSKAAAIEFDLDKDNYIKWAQPTDENAGQSPTLAILGPMDVTVFLWINRVVWLAAFDALAPYHETAVGVYSQIPRRPSSESATNRNLNIAALHAQHGVWKRVLPQQVDQLRELMTALGLDPSDETENLSSPVGIGNVAAKNAFNALKNDGMNFLGYEGRKYNPRPWADYTGYEPVNTAFKVNNPSRWQPQLQAHNARRAGGGPGDLGIYVTQHFVTPQTARTKAHIFRDPSRFRIPRPEFSDHTNTRAYKRSVDEIIDASANLNDERKALAEIMENKLWGIGHSSIVIANKYDQNNEMGVHGWCHWMLAHVLATFEPLIAAWHHKTRFDAVRPVTAIRHVYGNRKIRAWGGVGMGTVDIRASEWSSYLPVGDHPEYPSGSTSLCSATSQAARRYFDSDELDWTINYPAGSTVVEPGITPGKDLSIHIPTWTDFTRTCATSRVWGGVHFQTTVDRTIDFGEQFGDLAHEFVQRHVKGDVKD,CC(C)=CCC/C(C)=C/C[C@]1(O)C(=O)c2cc(O)c(C)c(O)c2C(=O)[C@@]1(Cl)CC=C(C)C,CC(C)=CCC/C(C)=C/C[C@]1(O)C(=O)c2cc(O)c(C)c(O)c2C(=O)[C@@]1(Cl)CC=C(C)C,[C;D1+:1]=[C;D2+:2]-[C;D2:3].[O;D0+:4]>>[C;D2+:1](-[C@;D3+:2](-[Br;D1:5])-[C;D2:3])-[O;D1+:4]
aries-halogenase-2c8956be0d58b5e7e669,1,MGVVSADQAHLEILNSNPYETRDFFWEQHRFARDGYLKINHLIDPLVRDAIMVDVKYLMAHHAKRRDFLIESTGNTPRYLSNVSRDNIEEFGRYIPLAYKSQYLMSLIGNIVKEEVIPTPWKWDNYIINSQHKSGDTHGWHWGDYPYTIIWIVEAPSIECGGLLECVPHTNWDKKNPRVENLLVENSIDSYFHITGDVYLLKADTTLHRVKPLTKDVQRIILNTTWERARDRDRHVEHETFVFRD,CC(C)C[C@H](N)C(=O)O,CC(C)C[C@H](N)C(=O)O,[C;D0+:1]>>[C;D1+:1]-[Cl;D1:2]
aries-halogenase-a969134526e51e5f0a61,1,MHAPAPSESQRLVRRVVIAGGGTAGWMAAAALSKLLGRQLQITLVESDEIGTVGVGEATIPSLVTFHRLLEIDEAQFMAATQATFKVGIAFEHWRDVDRHYIHSFGHTGTDHWSAGFQHFWLKAHARGVARDFGDYCLELRAAQEGRFAHLPNGGMNYAYHLDAGLYARFLRRFSEGFGVQRIEGRIGSVQTDAHSGDIAALVLDDGTRIEGDLFLDCTGFRALLIGQTLGVGSEDWSRWLFADSALAVQTESVGAPVTFTRARADRAGWMWRIPLQHRVGNGIVYSSRYTDQDSAAQVLEHNLQGRALTTPRALRFTPNQRHRVWEKNCVALGLASGFLEPIESTNIHLIQRGIVRLLQTFPQVIDPVDIAEYNRQAAEEIAHIRDFVILHYHATDRRDTAFWRDCASMEIPDSLRHRMELFRQSGRVFHQGNELFAENSWIQVMLGQGIVPRHHHPVADLMGDAELSQFLEGIRQRVEATLARLPPHAEFLRRYCPAPAPPAPMPQPAPGTPLAAPAA,c1ccc2[nH]ccc2c1,c1ccc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-84b504f830bf8b6d2c23,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLEGSGIYFIYAAIHMLARHFPDKTFDKVLVDRFNREVEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-748595a8693a6fb4962d,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-3c06bc19eae1dddc102f,1,MNTRNPDKVVIVGGGTAGWMTASYLKKAFGERVSVTLVESGTIGTVGVGEATFSDIRHFFEFLDLREEEWMPACNATYKLAVRFQDWQRPGHHFYHPFEQMRSVDGFPLTDWWLQNGPTDRFDRDCFVMASLCDAGRSPRYLNGSLLQQEFDERAEEPAGLTMSEHQGKTQFPYAYHFEAALLAEFLSGYSKDRGVKHVVDEVLEVKLDDRGWISHVVTKEHGDIGGDLFVDCTGFRGVLLNQALGVPFVSYQDTLPNDSAVALQVPLDMEARGIPPYTRATAKEAGWIWTIPLIGRIGTGYVYAKDYCSPEEAERTLREFVGPEAADVEANHIRMRIGRSEQSWKNNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKHFPAGDWHPQLRAGYNSAVANVMDGVREFLVLHYLGAARNDTRYWKDTKTRAVPDALAERIERWKVQLPDSENVFPYYHGLPPYSYMAILLGTGAIGLRPSPALALADPAAAEKEFTAIRDRARFLVDTLPSQYEYFAAMGQRV,O=C(O)c1ccccc1Nc1ccccc1,O=C(O)c1ccccc1Nc1ccccc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-ee65fbaffa5773d9a2ed,1,MSTLPNSTQILIIGGGPSGSTAATLLAREGFDVTLLEREVFPRYHVGESLLPSALEIFDLLGVREKIEAYGFQRKPGAYIEWGTEKWSLNFGELTGDNTYSFQVRRDEFDHLLLEHSKSQGVKVFEGTKIRQLSFDGDRPRSATWSQSNDTTGEISFDFMIDASGRAGIMATEYLKNRRLHDVFQNVGIWGYWKNALRLPKGQSGAIALGSIPDGWVWGIPLDEEIMSVGVVMHKSTYKERLTKNLKDIYVEAIAECPLIADLVALGELVSDVKVEQDYSYTSDSFSGPAYFISGDAACFLDPLLSSGVHLATYSALLAAASITSVIRGEVTESQAASFYDQSYRQAYLRFLVFVSAFYDQNRGKDSYFWEAQRLSRRDFGSSNLKLAFLNLVSGVEDLEDAKEGIADFVMAEMSQRIQSSHSIRQDKQALAIEREKGNEVMKTNAQFFNAVEGFSILSAVGAVDGLYVTTQPKLGLVQVIPLQRNSLLHT,NC(Cc1ccc(O)cc1)C(=O)O,NC(Cc1ccc(O)cc1)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-6c663502b8bd484640be,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,CC(=O)N1CCc2ccc(N)cc21,CC(=O)N1CCc2ccc(N)cc21,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-6bf79d7d0a4f78414c0c,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYRGNFEEEFRNPWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-5246272819cf9d3f50bd,1,MENSTQVLVIGGGPGGATTAGLLAREGISVTLMEKETFPRYHIGESLLPSCQPILELLGVREKVESRGYQRKRGAYFDWAGEKWDVTFGDPTDDRASSYQVLRSDFDQVLLEHARELGVTAFEGAEVQRLTFDGDRPRSAVWSQPGAGITNAEITFDHVIDASGRSGLMTTRHLRTRRYHEVFRNIAVWGYWKNATPLPAGPEGAIAICYVPDGWLWGIPLGDGQLSVGLVTHRDVFNSRRQNGESLESIYHAAIRESPVIENLLPSAELVSSLRAEQDYSYTSERFSGPGYFLVGDAACFLDPLLSTGVHLAMYSALLAAASLASVLRGEFGEEAARDLYDRSYRQAYLRLLVVVSNLYQQNQGKDSYFWEAQRLTLRDANPDEIKQAFVDVVSGIEDLRDAQATLDTAVEATGMAMAQWDGWHWNPSALNHSELTESEWKKALDGSQDIDSLAPGERELAAARARFFDTAMQRVLGPVPQGGQGLYVVTRPRLGLANLQ,O=c1c(-c2ccccc2)coc2cc(O)cc(O)c12,O=c1c(-c2ccccc2)coc2cc(O)cc(O)c12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-6989c356365e78e1e2be,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLEGSGIYFIYAAIHMLAWHFPDKTFDKVLVDRFNREVEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-474fb66b62ee34d4dfb3,1,MNTRRQQAQNIRNNAAELAANRPHPQHINNKEEYEYRRPKKDGNEPSHIANFTKGLPHDEHTGLLLNSADYDQFVLGIQSGDTTDFARTPLGPAELPKVHGCLSKQKIDCDDDHRSGFWKSQIAQGAAGGDGAKLRAWESAGAGLVFDLEGPDAQAVTMPPAPRLESPELTSEIAEVYSQALLRDIHFSQLRDPGLGDQVNACDSCPTQLSIYEAIDILNTVQIEGQNWFSANCCDLTDDEQARQRPLVTRQNIFRGIAPGDDVGPYLSQFLLIGNNALGGGVFGQEAGHIGYGAIRIDQRVRKATPCKDFMTNFETWLDVQNGADLRGLETYVDADPGKCREFPAYRVITTPRDLATYVHYDALYEAYLNACLILLGMGAPFDPGIPFQKPDVEDKQQGFAHFGGPQILTLVCEAATRGLKAVRFQKFNVHRRLRPEALGGLVDRYKHGKGAGDELKPVAALVEALENVGLLSKVVAHNQLQNQNLDRSGDPSSAGDNYFLPMAFPEGSPMHPSYGAGHATVAGACVTMLKAFFDHGWQLNLGMANGKYISYEPNQDGSSLQQVLLDCPLTVEGELNKIAANISIGRDWAGVHYFTDYIESLRLGEKIAIGILEEQKLTYGENFTMTVPLYDGGSIQI,COc1cccc(OC)c1,COc1cccc(OC)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-06d6cd09cf62841e901a,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNPWSNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccc(C)cc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-cd145ae2eb8cf90aca55,1,MKHGGMASGAIERVVIVGGGTAGWMAAAALGAYLAGAGTRITLIESSEIGTIGVGEATIPTIRRFYAALGMTDAEVMRACEATAKLGIRFVDWKPGTSFVHPFGRFGQDLRGIDFHQYWQKARQAGRAAPLEEYSLGAMLAREGHASVPLPNPPSQLSVFDWALHFDAARFAAHMRAYAERAGVARIDARITDVTLHGETGFIEAVTLDSGERVAGDLFVDCSGFRGLLIGEALGTPYRDWSHWLLCDGAFAVQSERVGEPPSCTTVTARTAGWQWRIPLRSREGNGLVFASDFQGDDEARAELLANIPGAPTMEPRRLRFTPGRREVAWARNCVSLGLASGFLEPLESTSIALIETGIERLKQLFPDKGFDPAVIAEYNAQSAEEMERVRDFILLHYHLSTRDGPFWQACREMTLPDSLAAKLELWRARGAFLRYRWEMFSPASWLAIYGGFEHLPERLDPGVAAVGTDELAQGLEQMRAAIARTVADTPTHSEFLATVDGAAAEPMRTSV,Cc1c[nH]c2ccccc12,Cc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-4cedaf7dcf3a15cd223d,1,MARSEESNTLARLFDVLGDDAAAAREWVTEPHRLIASNERLGTAPEAPADDDPGAIRTVGVIGGGTAGYLTALALKAKRPWLDVALVESADIPIIGVGEATVSYMVMFLHHYLGIDPAEFYQHVRPTWKLGIRFEWGSRPEGFVAPFDWGTGSVGLVGSLRETGNVNEATLQAMLMTEDRVPVYRGEGGHVSLMKYLPFAYHMDNARLVRYLTELAARRGVRHVDATVAEVRLDGPDHVGGLITTDGRRLHYDFYVDCTGFRSLLLEKALGIPFESYASSLFTDAAVTGTLAHGGHLKPYTTATTMNAGWCWTIPTPESDHLGYVFSSAAIDPDDAAAEMARRFPGVTREALVRFRSGRHREAWRGNVMAVGNSYAFVEPLESSGLLMIATAVQILVSLLPSSRRDPLPSDAANQALAHRWDAIRWFLSIHYRFNGRLDTPFWKEARAETDISGIEPLLRLFAAGAPLTGRDSFTRYLADGAAPLFYGLEGVDTLLLGQEVPARLLPPREPPEQWRARAAAARSLASRGLRQSEALDAYAADPCLNAELLSDSDSWAGERVAVRAGLR,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-d7d145410c61e49f9f6e,1,MVSVRRAEPTDRAATDVPHEREPGAEVTGGPRDGVGDAPAWISLTTDYGLADGFVAACHGVIGRLAPAARVIDVTHLVPPADVRRGAAVLAQTVPYLPVGVHVAVVDPGVGTARRGIALATPGGLLVGPDNGLLLDAATTLGGVTSAVELTNPHWLAPEVSRTFHGRDVFAPVAARLALGAPLAGAGPAVDPAGLVRLPEPVVRSGDGGLTAEVLTVDHFGNVQLAAPGGLLAALPARLRVAGRPATHGRTFGDAPPGELVVHVDSAGRVAVAVNGGRAADVLAVGPGDLVSVTATAEEPPGRPAGAEIGPLPD,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,[C;D1+:1]-[C;D2+:2]-[S;+;D3:3]>>[C;D1+:1]-[C;D2+:2]-[Cl;D1:4]
aries-halogenase-12ce6d8c7cd5e52fb704,1,MLDAIVMGGGPAGSVCAAVLARQGRSVLVLERQEFPRFHIGESMLPYMVGLLERHGLLDAVREQGYVVKRGGEFIDPTGTKFFRAGVFRADFAKTGDGRHHETFQVERSHFDRVNLDQARAAGATVREGAQVVGLLEEGGRVVGVRYREGGVEREERARYVVDATGRAGVVANRFGLRRMIEDLRMVAVFHHRDGLDEAHNPGHEGDIQVGSHSDGWIWAIPLSADRISVGTVMHRDRLRGRTPAEAFAEHVERVPRINQRLTGTSATSDFWVETDYSYHSDQVTGPGWVMVGDAGCFGDPMFSGGVLVGMATGAEAAEALGRALDSPADEEQALTGYSNFFKTGYDTYVRLIFSFYEGELLPALAEAHSEAGNLSEADMEMYVVRLLGGDFWSARNPVANALRANPAWSTFSPFEPVHRCPVYPELDVAELGGLAGTVGR,C/C1=C\C[C@H](O)/C=C/[C@H](C)[C@@H](O)[C@H](C)/C=C(\C)C(=O)c2c(O)c(C)cc3c2C(=O)C=C(NC(=O)\C(C)=C/C=C\C=C\[C@@H](C)[C@@H](O)CC1=O)C3=O,C/C1=C\C[C@H](O)/C=C/[C@H](C)[C@@H](O)[C@H](C)/C=C(\C)C(=O)c2c(O)c(C)cc3c2C(=O)C=C(NC(=O)\C(C)=C/C=C\C=C\[C@@H](C)[C@@H](O)CC1=O)C3=O,[C;D1+:1]=[C;D3:2]>>[C;D2+:1](-[Cl;D1:3])=[C;D3:2]
aries-halogenase-b767749a5f38ac3d8b5a,1,MHAPAPSESQRLVRRVVIAGGGTAGWMAAAALSKLLGRQLQITLVESDEIGTVGVGEATIPSLVTFHRLLEIDEAQFMAATQATFKVGIAFEHWRDVDRHYIHSFGHTGTDHWSAGFQHFWLKAHARGVARDFGDYCLELRAAQEGRFAHLPNGGMNYAYHLDAGLYARFLRRFSEGFGVQRIEGRIGSVQTDAHSGDIAALVLDDGTRIEGDLFLDCTGFRALLIGQTLGVGSEDWSRWLFADSALAVQTESVGAPVTFTRARADRAGWMWRIPLQHRVGNGIVYSSRYTDQDSAAQVLEHNLQGRALTTPRALRFTPNQRHRVWEKNCVALGLASGFLEPIESTNIHLIQRGIVRLLQTFPQVIDPVDIAEYNRQAAEEIAHIRDFVILHYHATDRRDTAFWRDCASMEIPDSLRHRMELFRQSGRVFHQGNELFAENSWIQVMLGQGIVPRHHHPVADLMGDAELSQFLEGIRQRVEATLARLPPHAEFLRRYCPAPAPPAPMPQPAPGTPLAAPAA,OCCc1c[nH]c2ccccc12,OCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-3c8a2ab40a0c12216893,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,COc1ccc(N)cc1N1CCCC1=O,COc1ccc(N)cc1N1CCCC1=O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-c45c01c3885bc0866695,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,OCCc1c[nH]c2ccccc12,OCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-6c0b123ec6a6739341f0,1,MQLPSSTKILVVGGGPAGSTAATLLAREGFEVTLVEKAIFPRYHIGESLLISVQPIIDLLGAREAVEAHGFQRKKGVLWEWGGERWLFDWKKLRYDYTFHVKREEFDEILLRNAQKNGVKVFEGIDISRLEFDGERPVAAKWSKSSTGESGTIQFEFLLDASGRAGLMATQYLRSRMFMKAFQNVATWGYWKGATIPEVEVEGPITVGSIPYGWIWGIPLRDQTMSVGLVIHQELFKEKRATQSVEEIYHEGLKASPLFQDVVLKGATLEPQIRTETDYSYISRTLAGPGFFLVGDSGAFIDPLLSSGVHLAMHSALLAAASVKSIIAGEVDMASATEFYQRCYQGHFLRWALIVASFYEVNARKETYFWTAQQLAHEELGVFNMSQADMKDVFATMVSGVVDLGDAQNAGRLQKGAERVHQYLDDDGREEDVTALLQKSKQRIFEYLDRVKNRDSRAAMQRYKAGGTETFSMGLDADGAVGGLYVTTEPRLGLLRKVVEERAEAATEAPAPAAPPPAVAEV,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-24250bf69bbdf1a9d687,1,MTTVSEQANFTFSPEEVARFERDGYIGPVKIFEPEEMTRRWNIIRRQLLDRSLAIYPDSNGKANISNYDRHLDIDLLAEHIMRPEIVDRVGSLIGRNLLCWRSEFFPKYQGDEGTDWHQAATFAHATGKPQIIWPSDEGRPAFIGTITVWTAFTHSTEQNGCLQLMPGTHTSMNYDESKGMDYDADAINQREKDGIKRGFFGYDYRSLQKDPDWKPDESQAYPMVLKPGEAVIFWSNTMHASLPHTGSKTDYRMGFAARYVPTQVQVYPGTENLTEYGDGINLEKYGAVLTSGVDEYGHNRIARTSQRGYEFVPRQIPS,CCC(N)C(=O)S,CCC(N)C(=O)S,[C;D0+:1]>>[C;D2+:1](-[Cl;D1:2])-[Cl;D1:3]
aries-halogenase-f5475c3cab1c59e829fd,1,MIPAPLRNIVIVGGGTAGWMAAAAFARVLGPSFNVQLIESEQLGTIGVGEATVPHIKAFNNLLGIDEAEFVRQTQGSFKLGIEFVDWQRPGTSYIHGFGTQIGHPLGLLPFHQYWIKQQRRGKAQPLGAYTLNTVAATRGKFMTSAGDVPANSPLASIAYAYHFDASQYARFLRGYAEQRGVTRLEGLIEQVQLDAHTGSVQSVQLASGQVVSGDLFIDCSGFRGLLIEEALHTGYHDFTHWLPCDRALAVPCEKVGPPTPYTRSTARAAGWQWRIPLQHRTGNGYVYSSAHISDDEAAAALLANLDGTPLADPRPLRFTTGRRKQFWNRNVVALGLASGFLEPLESTSIHLIQSGISKLLELFPREGISPVLVQRYNDRLAFEFDRIRDFLVLHYHATERDDSAFWRHCRTMPITPELQTTLDLFRDSGRFYRNAEEMFAEISWVQVMVGQGILPQGYHPLVDQVPDTDAEGFLASVAQTISHCVDVMPTHQQFIDRYCRADPVR,O=C(O)CCc1c[nH]c2ccccc12,O=C(O)CCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-64200427fa85338cb264,1,MKIESVAIVGGGSSGWMTAAALSKLCPQLEIALIEDPNIKTVGVGESTLGHFNKFLHLLDLKDEDWMPACNATYKNSIRFTNFREGKGEVFEYPFGPSLDVSFFSQTDGINTWGKLANKYPEDFPPETFARFVNSNTYLAEHNRLTRNKDNKIPNFNFDWDTAYHIDAELFGQYLKEKIALPNGVKHIQGKVTGYQKESPNNHNFKYIILDQETAIFADLYIDCTGFKSLLLGEFMGEAFSPFSKKLANDKAMATRIPYENREEEMHNVTDCHAMKNGWVWNIPLWNRIGTGYCYSSRFVSKDDAEAEFREHLGERGKDAKIFHIDIGHGKRTRAWVNNCVGIGLSYGFIEPLESTGLLTTHENIENLVYLINQRDGYVTQAERDGFNYTCDHQIDSFSDFVAMHYAYSMRTDTPYWKWCTQMCNYMPESMGPHRQKQSTWQDLSTDTIGLNTWHINHNGISFIIAGHGLRPQSYDKLSEVLLKRNNESDYYYEDIRKDWLKHYESMVEYVKTLPTHYEFLRDEIYGSAE,Nc1ccc2ncccc2c1,Nc1ccc2ncccc2c1,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-3d1d7ba7ee26cca42042,1,MLRGGIAGASAAALAGLGHSGSAAAEPAGQAGAAATDFDFDTGNFVRDLIATFRPAEDVYGPMDVTVLHRFIHLSTAAWFDALAPYHPTAVGVFSRIRRRPSSESTTNRNKNIAALYANYRVIKGVEPGRGTAFRDLMVTIGLDPDDESENLTSPIGIGNLAGKAVLARTAHDGMNQLGDEGRTYNGRPYEDYTGYRPVNSAYELRNPSRWQPKHGTHNRRLAGNAGDKGIFTVQAFVTPQQSLVRAHTFRDPGGFGLAPPEFSDHTRPRDYKRSVDEILQASAALTDEQKVKAEIFDNKFLGVGISVGAAAQAHGEMDLDDLVHLLFGSTVAIYDSLVAIWHYKAKYDSVRPFSAVRHIYGSRRVTSWGGVGKGTVRDMPGDEWTSYLNVGDHPEYPSGSGGVCAAQAQATRRFFDDDVLDWTFRAPAGSTMVEPGLTPGTDIALHWDTWTEFVRDCAYSRLWGGVHFSKTAERSIPFGEQFGDLAYEFVQRHVRGEVGED,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-0329694ac22521cc5942,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Cc1[nH]c2ccccc2c1CCN,Cc1[nH]c2ccccc2c1CCN,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-8ae4ab086c08b2569512,1,MTDTTADQTRHGDRPYDVVIIGSGLSGTMLGSILAKHGFRIMLLDGAHHPRFAVGESTIGQTLVVLRLISDRYGVPEIANLASFQDVLANVSSSHGQKSNFGFMFHRDGEEPDPNETSQFRIPSIVGNAAHFFRQDTDSYMFHAAVRYGCDARQYYRVENIEFDDGGVTVSGADGSTVRARYLVDASGFRSPLARQLGLREEPSRLKHHARSIFTHMVGVDAIDDHVDTPAELRPPVPWNDGTMHHIFERGWMWIIPFNNHPGATNPLCSVGIQLDERRYPARPDLTPEEEFWSHVDRFPAVQRQLKGARSVREWVRTDRMQYSSSRTVGERWCLMSHAAGFIDPLFSRGLSNTCEIINALSWRLMAALREDDFAVERFAYVEELEQGLLDWNDKLVNNSFISFSHYPLWNSVFRIWASASVIGGKRILNALTRTKETGDDSHCQALDDNPYPGLWCPLDFYKEAFDELTELCEAVDAGHTTAEEAARVLEQRVRESDWMLPALGFNDPDTHHINPTADKMIRIAEWATGHHRPEIRELLAASAEEVRAAMRVKP,CN(C)[C@@H]1C(O)C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)cccc4[C@@](C)(O)C3CC12,CN(C)[C@@H]1C(O)C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)cccc4[C@@](C)(O)C3CC12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-37d2c05e6320b12b5d1c,1,MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPAFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEAR,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-8780876d4ec2824442d2,1,MGIPADNLQNRAKASFDTRVSAAELALARGVVPSFANGEELLYRNPDPENGDPSFIASFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIADLTLGPARDPDTGLPIWRSDLANSLELEVRGWANSSAGLTFDLEGPDAQSIAMPPAPVLTSPELVAEIAELYLMALGREIEFSEFDSPKNAEYIQFAIDQLNGLEWFNTPAKLGDPPAEIRRRRGEVTVGNLFRGILPGSEVGPYLSQYIIVGSKQIGSATVGSKTLVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLDVQDAADFRGFESYEPGARLIRTIRDLATWVHFDALYEAYLNACLILLANRVPFDPNIPFQQEDKLDNQDVFVNFGDAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKIAAEKGESIFPEVDLAVEELGDILEKAEISNRKQNIADGDPDPDPSFLLPMAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDSNFQIDQVFEVDKDEDKLVKSSFKGTLTVAGELNKLADNIAIGRNMAGVHYFSDQFESLLLGEQVAIGILEEQSLTYGENFFFNLPKFDGTTIQI,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-b6cbf3829f323ff95219,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATMPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPFGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNFWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-4e3f79891e92947d976e,1,MTASESSSASSFSLQRRSLLAGTATAVLLPLGNISTATASQATRSESKSSCGFDLDTDNFIQYLSDNTDTSAVSDFIAPMDVTILIRYTCMAHNAWFDALAPYHPTAVGVYSKLERRPRSEARTNRNKNIAALYAWRHVMKSVVPAGMPTFRSLMNSFGLDPDDNSEDPTTPVGIGNLAGKAVVAARVRDGMNQLGNEGARYNGKSYEDYTGYRPENSAYELRNPSRWQPELLEHGRRLGQGDGDKGMFMIQVFTTPQMRLTTPYTFEDPSKFPLSPPAHSDHTDRANYKRSVDEVLEVSAGLTDEQKVKSEFFDNKFLGVGMSTLVAAENHELDLDGWVQLLMMTGVAMLDGLIACWHYKNKYDSVRPFSAVQHLYGTTELTAWGGPGVGAVNDIPANEWTSYLNVGNHPEYPSASTTVISAEAQAARRYLNSDSLNWSYTYPAGSSLVEPGITPARDLEMRWATWTDFVQDGSTSRLWGGVHFSKSADDSIDFGTQFGDLAYEYVRRYIDGSVR,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-dd4bdbced5abdb1a29f6,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATMPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPFGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNLWNNSNYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-fcee7e430b7b06184e4d,1,MTSGNSSSAGFSPARRSLLLGGASTAALATLGTGTAAAAGQGTGPAAKPAAAAEFDFDTGNFHRDLLSTAANPSEEPLGPMDATVLVYLTHLTMTAWFDALAPYHPTAVGRHSRIPRRPASESNTNRNKNVAAFHAANVVFQSVFKERVAAFRQLMTTLGLDPDDQSTDPTSPVGIGNLAARGVLKAKARDGMNLFGDEGRKYHGQPYEDYTGFEPVNTAYKLVNPSKWQPARHPHRRRVGGGPGDKGIFVVQHMVTPQMALVKPDTYRHPSQFPLAPPDHLDHTDPRRYKRSVDEILEASATLDDEQKVKAEFFDNKFLGIGQSTKAAGIAHDLELDDWVHLIYTSSLAQVEDLIAAWHYKVKYQAPRPFSAIRHVYGKKKVSAWGGPGIGTVHDMPADEWASFLPVGDHPDYPSGSTTLCAAEAQAARRFLGDDRLDWTWPIPAGWTLTEPGITPARDMELHYGTWTEFVKDCGYSRLWAGVHFTTTVERSMEFGTQFGDLAYEFAQKYIKGDVED,CC/C(C)=C/CC/C(C)=C\C[C@@]1(O)C(O)=C(Cl)C(=O)c2c(O)cc(O)cc21,CC/C(C)=C/CC/C(C)=C\C[C@@]1(O)C(O)=C(Cl)C(=O)c2c(O)cc(O)cc21,[Cl;D1:1]-[C;D2+:2]=[C;D3+:3](-[O;D1:4])-[C;D3+:5](-[C;D1+:6])-[O;D1+:7]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:8])-[C@@;D4+:3](-[C;D1+:6])(-[O;D1:4])-[C;D2+:5]=[O;D1+:7]
aries-halogenase-68fb74e20a2f319724f1,1,MKTRAKAELSYYLSVEEKQFFRDNGYIGPFTLFQPEEILELWNEIRMDLLDRETAPFPNSKMNYDRHLDIQALSDIISHPKIAHRVSSLLGSNVLCWRTAWFPKYPGDEGTDWHQAESFVEFEGKSKLVPTESHDGPWELTAWVAFSEATRENGCMKVMPGTHNTWYFDEHRNIEFEPDKINQKLTGGKKTGVYGYDYYKLKLDPNWEPDESQAVHLEMEPGQFILFTSRCMHGSEPNTSGSSIRYGWSTRFVPTDVRVYPDWESFQHFGEVFPLERYATVLVAGEDTYKHNKIRRPLGQ,C[C@H](CCl)C[C@H](N)C(=O)S,C[C@H](CCl)C[C@H](N)C(=O)S,[C;D0+:1]>>[C;D2+:1](-[Cl;D1:2])-[Cl;D1:3]
aries-halogenase-00431bea7c112c6c03ed,1,MGIPADNLQSRAKASFDTRVAAAELALARGAVPSFANGEELLYRNSETGDPSFIGSFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIAALTLGPARDPETGLPIWRSDLANSLDLEVRGWENSSAGLTFDLEGPDAQSVAMPPAPVLTSPELIAEMAELYLMALGRDIEFSEFDSPKNAAFIRSAIERLNGLEWFNTPAKLGDPPAEIRRRRGEVTVGNLFRGILPGSEVGPYLSQFIIVGSKQIGSATVGNKTLVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLDVQDAADFRGFESYEPGARLIRTIRDLATWVHFDSLYEAYLNACLILLANGVPFDPNLPFQQEDKLDNQDVFVNFGSAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKNAFLKSESVFPEVDVLVEELSSILDDSASSNEKQNIADGDVSPGKSFLLPMAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDANFQIDQVFEVDTDEDKLVKSSFPGPLTVAGELNKLADNVAIGRNMAGVHYFSDQFESLLLGEQIAIGILEEQSLTYGENFFFNLPKFDGTTIQI,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-11107fb1986588aba7b8,1,MNNPDALRKVCIVGGGTAGWIAAAVMAHHMKGRLFEIELVESDDIGTIGVGESTIPPFMELIAKLDIDEQDFVRQVQASFKLGIEFKDWFRKDESYFHPFGDVGQRVELSDFYQCWRKATLAGHDFPLQDFAPATVMAHAGRFMLPFKARNTPIAGASYALHVDAKRVAQFLRGHAEARGVKRTEGIVTDVALDARGFVSTLTLKDGRTIDADFFIDCSGFRALLIEKALGSGYTDWSNYLFCDRAIAAQTENVGPPRPYTLAEAQDAGWRWRIPLQHRTGNGHVYSSEFMSDEEATRILLEKVEGEVVAGPMVVPFRTGVREKIWHRNVLAIGLSSGFIEPLESTAIHLIYRGMDFFFRFLPDRHCDPALADEYNRRMVADYTEIRDFIVLHYCTTARDDTPFWRKCRDMDWPDSLKERVELFRSNGTLREGLDELFRSVSWFSVLEGMGIRPRTYHPLVDRIDEAMLYAGLDKAREQLAGFVRQLPTQQQFIDAHCRAEKVDLTRPVMAGV,Cc1[nH]c2ccccc2c1C,Cc1[nH]c2ccccc2c1C,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-7ce6f63886c83962b9cb,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYRGNFEEEFRNPWTNGSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-4c4192b3de0f23475bdb,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,Oc1ccccc1,Oc1ccccc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-eb7015b56be919a2c96c,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATHPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNCWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,NCCc1c[nH]c2ccccc12,NCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-5c5fab9d41e71379263a,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWCPLSGVRDDGRPDHGDPFWLTLGAPATNTNDVPFKPPFPAYPSGHATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-5d83968035f50b364478,1,MGSVTPIPLPKIDEPEEYNTNYILFWNHVGLELNRVTHTVGGPLTGPPLSARALGMLHLAIHDAYFSICPPTDFTTFLSPDTENAAYRLPSPNGANDARQAVAGAALKMLSSLYMKPVEQPNPNPGANISDNAYAQLGLVLDRSVLEAPGGVDRESASFMFGEDVADVFFALLNDPRGASQEGYHPTPGRYKFDDEPTHPVVLIPVDPNNPNGPKMPFRQYHAPFYGKTTKRFATQSEHFLADPPGLRSNADETAEYDDAVRVAIAMGGAQALNSTKRSPWQTAQGLYWAYDGSNLIGTPPRFYNQIVRRIAVTYKKEEDLANSEVNNADFARLFALVDVACTDAGIFSWKEKWEFEFWRPLSGVRDDGRPDHGDPFWLTLGAPATNTNDIPFKPPFPAYPSGAATFGGAVFQMVRRYYNGRVGTWKDDEPDNIAIDMMISEELNGVNRDLRQPYDPTAPIEDQPGIVRTRIVRHFDSAWELMFENAISRIFLGVHWRFDAAAARDILIPTTTKDVYAVDNNGATVFQNVEDIRYTTRGTREDPEGLFPIGGVPLGIEIADEIFNNGLKPTPPEIQPMPQETPVQKPVGQQPVKGMWEEEQAPVVKEAP,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-c34091bdd840eb499ca5,1,MSTRPEVFDLIVIGGGPGGSTLASFVAMRGHRVLLLEREAFPRHQIGESLLPATVHGICAMLGLTDEMKRAGFPIKRGGTFRWGKEPEPWTFGFTRHPDDPYGFAYQVERARFDDMLLRNSERKGVDVRERHEVIDVLFEGERAVGVRYRNTEGVELMAHARFIVDASGNRTRVSQAVGERVYSRFFQNVALYGYFENGKRLPAPRQGNILSAAFQDGWFWYIPLSDTLTSVGAVVSREAAEAIKDGHEAALLRYIDRCPIIKEYLAPATRVTTGDYGEIRIRKDYSYCNTSFWKNGMALVGDAACFVDPVFSSGVHLATYSALLVARAINTCLAGEMSEQRCFEEFERRYRREYGNFYQFLVAFYDMNQDTDSYFWSARKIINTEERANEAFVRLIAGRSNLDEPVFQSVAKDFFTEREGFGAWFGGLVTSMAKGDGGGLMVGEGATDATESTGFAPENFMQGFTREITELQHLAMFGEDRGPETPLWSGGLVPSRDGLAWAVESGEDAAG,N[C@@H](Cc1ccc(O)cc1)C(=O)S,N[C@@H](Cc1ccc(O)cc1)C(=O)S,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-75708f8c8b2929289c50,1,MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNFEAEFRNFWTNGSYYCIFTGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESLPSTYDLLRQLHGAS,NC(Cc1c[nH]c2ccccc12)C(=O)O,NC(Cc1c[nH]c2ccccc12)C(=O)O,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-a72c3d511056e072040c,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,COc1ccc2[nH]c3c(c2c1)CCNC3,COc1ccc2[nH]c3c(c2c1)CCNC3,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-0e74fa5f84db6f9d5f38,1,MDHYTHVQFDWARRNAAFDVRLRAAVQSRDASYSGDDGHVTNGDEARFPTTLLGTFTKGLPHSLPLALPTDRSAFDAFVSGVNTGDLDTIKSIPLGPDPEGDNSFSSSAMTTGAKVRGWESMAAGLAFTLEAPDPQRVTMPPAPQIDSVELGYELSESYWMALCRDIAFTEFDNSDTVAEAAASMAAHAWVAEDGCDQLGELTPTQTAHRELEMKNGEGITQGTIFRGSLNGDNIGPYLSQFLLIGCDTLGSRFSKDDPESYLTGHIRFGAHRIDQRVRKAVPDRDYMTTWGAYIDVANGADVRGRESYVTAEGDNFNDEETHRFIHTPRDLATYVHYDALYQPYINACLLMLAMGIEYDAGLPFGDEDEVDKQTGFALFGGPHILSLLAEVVLKALKAVRFQKFAMHRRARPETVAGWIDCVQRPRTSDEQEGNEGQTVFKPIEKLCQYVDSDLLQKVREHNVTQNNTQMDRDIARLYDYDPVDTVADCSAEQQEEQTEDEGQQQQQGGTYLLPMAYAEGSPMHPAYGAGHATVAGACTTILKAFFDTTQTLPYAFTSTEDGTKLTQIEVDEPLTVEGELNKLCSNISIGRNWAGVHWKSDYTESIKLGEEIAIGLLREQKNVYSEDFSMTIPLFDGSCVTV,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-151a4a9dbe25a542ee18,1,MKIESVAIVGGGSSGWMTAAALSKLCPQLEIALIEDPNIKTVGVGESTLGHFNKFLHLLDLKDEDWMPACNATYKNSIRFTNFREGKGEVFEYPFGPSLDVSFFSQTDGINTWGKLANKYPEDFPPETFARFVNSNTYLAEHNRLTRNKDNKIPNFNFDWDTAYHIDAELFGQYLKEKIALPNGVKHIQGKVTGYQKESPNNHNFKYIILDQETAIFADLYIDCTGFKSLLLGEFMGEAFSPFSKKLANDKAMATRIPYENREEEMHNVTDCHAMKNGWVWNIPLWNRIGTGYCYSSRFVSKDDAEAEFREHLGERGKDAKIFHIDIGHGKRTRAWVNNCVGIGLSYGFIEPLESTGLLTTHENIENLVYLINQRDGYVTQAERDGFNYTCDHQIDSFSDFVAMHYAYSMRTDTPYWKWCTQMCNYMPESMGPHRQKQSTWQDLSTDTIGLNTWHINHNGISFIIAGHGLRPQSYDKLSEVLLKRNNESDYYYEDIRKDWLKHYESMVEYVKTLPTHYEFLRDEIYGSAE,Oc1ccc2cnccc2c1,Oc1ccc2cnccc2c1,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-7263af08814e11782e31,1,MLLGGLGGAAALSAAGFTGMASASPRGSAGSKAAAIEFDLDKDNYIKWAQPTDENAGQSPTLAILGPMDVTVFLWINRVVWLAAFDALAPYHETAVGVYSQIPRRPSSESATNRNLNIAALHAQHGVWKRVLPQQVDQLRQLMTALGLDPSDETENLSSPVGIGNVAAKNAFNALKNDGMNFLGYEGRKYNPRPWSDYTGYVPVNTAFKVNNPSRWQPQLQAHNARRAGGGPGDLGIYVTQHFVTPQIARTKAHIFRDPSRFRIPRPEFSDHTNTRAYKREVDAIIDASANLNDERKALAEIMENKLWGIGHSSIVIANKYDQNNEMGVHGWAHWMLSHVLATFEPLIAAWHHKRIYDATRPVTAVRHVYGNRKIRAWGGVGMGTVDDIRASEWSSYLPVGDHPEYPSGSTSLCSATSQAARRYFESDELDWTINYKAGSTVVEPGITPGKDLSIHIPTWTDFTRTCGNSRVWGGVHFQTTVDRTIVFGEQFGDLAHEFVERHVKGDVKD,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Cl;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-0ac90a7368b506fee345,1,MKIESVAIVGGGSSGWMTAAALSKLCPQLEIALIEDPNIKTVGVGESTLGHFNKFLHLLDLKDEDWMPACNATYKNSIRFTNFREGKGEVFEYPFGPSLDVSFFSQTDGINTWGKLANKYPEDFPPETFARFVNSNTYLAEHNRLTRNKDNKIPNFNFDWDTAYHIDAELFGQYLKEKIALPNGVKHIQGKVTGYQKESPNNHNFKYIILDQETAIFADLYIDCTGFKSLLLGEFMGEAFSPFSKKLANDKAMATRIPYENREEEMHNVTDCHAMKNGWVWNIPLWNRIGTGYCYSSRFVSKDDAEAEFREHLGERGKDAKIFHIDIGHGKRTRAWVNNCVGIGLSYGFIEPLESTGLLTTHENIENLVYLINQRDGYVTQAERDGFNYTCDHQIDSFSDFVAMHYAYSMRTDTPYWKWCTQMCNYMPESMGPHRQKQSTWQDLSTDTIGLNTWHINHNGISFIIAGHGLRPQSYDKLSEVLLKRNNESDYYYEDIRKDWLKHYESMVEYVKTLPTHYEFLRDEIYGSAE,c1cc2cc[nH]c2cn1,c1cc2cc[nH]c2cn1,[c;D2:1]>>[c;D3:1]-[I;D1:2]
aries-halogenase-e59298ddda019f5e82d7,1,MIPAPLRNIVIVGGGTAGWMAAAAFARVLGPSFNVQLIESEQLGTIGVGEATVPHIKAFNNLLGIDEAEFVRQTQGSFKLGIEFVDWQRPGTSYIHGFGTQIGHPLGLLPFHQYWIKQQRRGKAQPLGAYTLNTVAATRGKFMTSAGDVPANSPLASIAYAYHFDASQYARFLRGYAEQRGVTRLEGLIEQVQLDAHTGSVQSVQLASGQVVSGDLFIDCSGFRGLLIEEALHTGYHDFTHWLPCDRALAVPCEKVGPPTPYTRSTARAAGWQWRIPLQHRTGNGYVYSSAHISDDEAAAALLANLDGTPLADPRPLRFTTGRRKQFWNRNVVALGLASGFLEPLESTSIHLIQSGISKLLELFPREGISPVLVQRYNDRLAFEFDRIRDFLVLHYHATERDDSAFWRHCRTMPITPELQTTLDLFRDSGRFYRNAEEMFAEISWVQVMVGQGILPQGYHPLVDQVPDTDAEGFLASVAQTISHCVDVMPTHQQFIDRYCRADPVR,OCCc1c[nH]c2ccccc12,OCCc1c[nH]c2ccccc12,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-90ee5a78aac96b480db1,1,MTQARIRKVVIAGGGTAGWVAAAALAHQFRGLLEIVLVESEQIGTIGVGESTVPPIRAFHRFLQIDEQEFLRAVAGTFKLAISFEDWQGQGDRYIHPFGSTGQGTLVCAFHHFWLEAQRRGMHSGFDEYCLEAQAARADRFAVLQQPAVNYAYHLDAGLYARFLRTHAQRYGATRIEGKIQQVRQHADSGFVEALVLEDGQVVEGDLFIDCTGFRGLLIEQTLHTGYEDWSHWLPCDRAVAVQTESVEPPVPYTRAIAHAAGWRWQIPLQHRVGNGLVYARAHLSDDEASAMLLAAVQGTPRRDPMLVPFVTGRRLQTWNKNVVALGLASGFVEPLESTSIHLAIVAVMRLITLFPADGIAQPQVDLFNRISRAEAEHVRDFVILHYHATQREEALWRQCRAMELPESLQLRLRAWREGAHAWQDGDELFRVDSWTHVLLGQRVAPAQHHPLTRALPDQHLQQLLDGIRQPLQHVVTQLPTQQAFIDSYCKVDQSTWG,c1cnc2[nH]ccc2c1,c1cnc2[nH]ccc2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-895c8504fe3e30686ef5,1,MEHYTHIPFDWARRNAAFDVRLRTAVQSREASYSGDDGHVTNGDEARFPTTLLGTFTKGLPHSLPLALPTDRSAFDAFVSGVNTGDLDTIKSIPLGPDPEGDNSFSSSAMTTGAKVRGWESMAAGLAFTLEAPDPQRVTMPPAPQIDSVELGYELSESYWMALCRDIAFTEFDNSDTVAEAAASMAAHAWVAEDGCDQLGELTPTQTAHRELEMKNGEGITQGTIFRGSLNGDNIGPYLSQFLLIGCDTLGSRFSNDDPESYLTGHIRFGAHRIDQRVRKAVPDRDYMTTWGAYIDVANGADVRGRESYVTAEGDNFNDEETHRFIHTPRDLATYVHYDALYQPYFNACLLMLAMGIGYDEGLPFGDEDEVDKQTGFALFGGPHILSLLAEVVLKALKAVRFQKFAMHRRARPETVAGWIDCVQRPRTSDEQEGNEGQTVFKPIEKLCQYVDSDLLQKVREHNVTQNNTQMDRDITRLHDYDPVDAVADCAVDQQQQVYEQQQTEDEQNEQQQQQRGGTYLLPMAYAEGSPMHPAYGAGHATVAGACTTILKAFFDTTQKLPYVFTSTDDGTKLVQIDVDEQLTVEGELNKLCSNISIGRNWAGVHWKSDYTESIKLGEEIAIGLLREQKNVYTECFSMTIPLFDGTCVTI,CC1(C)CC(=O)C(Cl)=C(O)C1,CC1(C)CC(=O)C(Cl)=C(O)C1,[Cl;D1:1]-[C;D2+:2]=[C;D2+:3]-[O;D1+:4]>>[Cl;D1:1]-[C;D3+:2](-[Br;D1:5])-[C;D2+:3]=[O;D1+:4]
aries-halogenase-fea2ab9d009eebd111ec,1,MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV,Oc1cncc2ccccc12,Oc1cncc2ccccc12,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-204ed30f363975c2fa94,1,MPGGRMSTGQHEEFDVVVVGGGPSGSTLSTLVAMQGHSVLLLEKETFPRYQIGESLLPSTIHGICHLLGVTDELAAAGFPHKRGGTFRWGASPKPWNFSFSVSSKVSGPTSFAYQVERSKFDKILLDNAARKGVVVRQDRTVTDVVDDADGRARGLRYTDPDGTEHEVSARYVVDASGNTSRIHKRVGGSRTYSDFFKSLALFGYFENGKRMPAPYAGNILCVAFGSGWFWYIPLSSTLTSVGAVVRREDAAKVQGDPESALRGLIDECPMIKEYLADATRVTTGQYGQLRVRKDYSYHHTTFWRPGMVLVGDAACFVDPVFSSGVHLATYSALLAARSLNSVLAGRIDERRAFDEFEARYRREYGVFYEFLTSFYDMHVDEDSYFWTAKKVTRSSHAELESFVELVAGMSSTDFDLSDAESSVLRLKQQSAEFADAVDDMAGRQEENMAPLFRSSAVSRAMQEGSQVQTRAQLGEYAGEDVPLFDGGLVASSDSMFWEEPHPS,N[C@@H](Cc1ccc(O)cc1)C(=O)S,N[C@@H](Cc1ccc(O)cc1)C(=O)S,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]
aries-halogenase-9ee00ea72efc54d7273b,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATIPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHSFGLLKYHEQIPLSHYWFDRSYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTNYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSLNPVLTARFNREIETMFDDTRDFIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPASDDAQLYYGNFEEEFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPQATESVDEVFGAVKDRQRNLLETLPSLHEFLRQQHGR,Cc1ccc2[nH]cc(C[C@H](N)C(=O)O)c2c1,Cc1ccc2[nH]cc(C[C@H](N)C(=O)O)c2c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-09ff4bb052ce045b24b7,1,MSGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEATTPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELDGGPDHFYHPLGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILDANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQRDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSRFATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSCFVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRDLIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPAPDDAQLYWGNFEEEFRNPWSNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQRNLLETLPSLHEFLRQQHGR,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,Cc1cc(N)cc(-n2c(C)nc3ccccc3c2=O)c1,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-d7a15df874f004db24bd,1,MTASYLKAAFGDRIDITLVESGHIGAVGVGEATFSDIRHFFEFLGLKEKDWMPACNATYKLAVRFENWREKGHYFYHPFEQMRSVNGFPLTDWWLKQGPTDRFDKDCFVMASVIDAGLSPRHQDGTLIDQPFDEGADEMQGLTMSEHQGKTQFPYAYQFEAALLAKYLTKYSVERGVKHIVDDVREVSLDDRGWITGVRTGEHGDLTGDLFIDCTGFRGLLLNQALEEPFISYQDTLPNDSAVALQVPMDMERRGILPCTTATAQDAGWIWTIPLTGRVGTGYVYAKDYLSPEEAERTLREFVGPAAADVEANHIRMRIGRSRNSWVKNCVAIGLSSGFVEPLESTGIFFIHHAIEQLVKNFPAADWNSMHRDLYNSAVSHVMDGVREFLVLHYVAAKRNDTQYWRDTKTRKIPDSLAERIEKWKVQLPDSETVYPYYHGLPPYSYMCILLGMGGIELKPSPALALADGGAAQREFEQIRNKTQRLTEVLPKAYDYFTQLR,NC(=O)c1ccccc1N,NC(=O)c1ccccc1N,[c;D2:1]>>[c;D3:1]-[Br;D1:2]
aries-halogenase-529f951b64739ac49f4b,1,MSDLGTTDDSVAQCKGLMLSICPGVTIVDVNHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTATRSVALRIKQAAQGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVIEEHGYIEAYEVSNTKVIPAEPEPTFYSREMVAIPSAHLAAGFPLNEVGRALSDDEIVRFAKPKPSTVSGGVLSGVITNIDHPFGNLWTNIHRTDLEKAGIGYQTQLRLLLDGVLTFDLPLVPTFADAGQIGDPVIYINSRGYLALARNAAPLAYPYNLKAGLTVTVTKA,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,C[S+](CCC(N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O,[C;D1+:1]-[S;+;D3:2]>>[C;D1+:1]-[F;D1:3]
aries-halogenase-b893116caf501ac2084f,1,MAIPQSCTVLVAGGGPGGSYTAAALAREGVDVVLLEADCHPRYHIGESLLPSMRYLLRFIDLEDTFEQHGFQKKLGAFFKLNAKSAGYTDFIRANGPNGYSWNVVRSESDEILFRHATKSGAKTFENVSLKSVNFEPYENDKFTSQDKLTNPGRPVSAEWKTKDGCSGTISFDYLVDATGRVGILSTKYLKNRKFNESFRNIAMWGYFKGNIPPSPGTDRENQPISEGMRDGSGWVWMLPLHNGTVSIGAVVRKDIFQAKKKALPEGTTEAQTLASLVALCPTISSYLEPAELASGIRQAADYSYSANAYAGPNFRIVGDAGCFIDPFFSSGHHLALSSALAAATSINACIRGDCNEFDASRWFAKKVDEGYTLFLVVVMAALKQIRMQEQPILSDLDEEGFDRAFTILRPVIQGAADKETAPKAKGESITETIDLCLTALNDLHDTELQRKLTSIVEAKGTPEQEQLLGKLSPDETAALHRMRAMHSILPMGELEDFENSNIDGFKARLEKGSLGLRRERALCRDHAGDLQM,COc1ccc(CC(C)NCC(O)c2ccc(O)c(NC=O)c2)cc1,COc1ccc(CC(C)NCC(O)c2ccc(O)c(NC=O)c2)cc1,[c;D2:1]>>[c;D3:1]-[Cl;D1:2]