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  1. cycle_70_lab_L0/exp_rl_pathb_650m_FULL_AUDIT_gspo_s2_20260506_125416/log.jsonl +101 -0
cycle_70_lab_L0/exp_rl_pathb_650m_FULL_AUDIT_gspo_s2_20260506_125416/log.jsonl ADDED
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1
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+ {"rl_step": 30, "loss": -2.9802322387695312e-08, "mean_return": 0.31219369173049927, "max_return": 0.6724172234535217, "mean_motif_chained": 0.31219370324999995, "gnorm": 2.7284841053187847e-10, "elapsed_s": 243.68428254127502, "cell_type": "Ex", "edit_type": "activity_boost", "target_tf": "MEF2C", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 2.9802322387695312e-08, "adv_std": 0.9999972581863403, "adv_min": -0.8609436750411987, "adv_max": 0.9933966398239136, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.31219370324999995, "comp_kd_mean": 0.0, "comp_total_mean": 0.31219370324999995, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
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+ {"rl_step": 40, "loss": 0.0, "mean_return": 0.1412220150232315, "max_return": 0.564888060092926, "mean_motif_chained": 0.14122202241015, "gnorm": 6.621121428906918e-10, "elapsed_s": 324.6805262565613, "cell_type": "Ex", "edit_type": "promoter_retarget", "target_tf": "NEUROD2", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.9999964237213135, "adv_min": -0.49999821186065674, "adv_max": 1.4999946355819702, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.14122202241015, "comp_kd_mean": 0.0, "comp_total_mean": 0.14122202241015, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
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+ {"rl_step": 45, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 364.8972692489624, "cell_type": "Ex", "edit_type": "promoter_retarget", "target_tf": "NEUROD2", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
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+ {"rl_step": 50, "loss": 2.9802322387695312e-08, "mean_return": 0.34825000166893005, "max_return": 0.699999988079071, "mean_motif_chained": 0.34824999999999995, "gnorm": 3.2378011383116245e-10, "elapsed_s": 405.3892285823822, "cell_type": "In", "edit_type": "activity_boost", "target_tf": "DLX2", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": -2.9802322387695312e-08, "adv_std": 0.9999974966049194, "adv_min": -0.8660014271736145, "adv_max": 0.874704897403717, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.34824999999999995, "comp_kd_mean": 0.0, "comp_total_mean": 0.34824999999999995, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
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+ {"rl_step": 55, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 445.6999132633209, "cell_type": "Ast", "edit_type": "activity_boost", "target_tf": "AP1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
13
+ {"rl_step": 60, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 485.54357051849365, "cell_type": "Oli", "edit_type": "cell_type_transfer", "target_tf": "NEUROD2", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
14
+ {"rl_step": 65, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 525.8183405399323, "cell_type": "Oli", "edit_type": "activity_boost", "target_tf": "MYRF", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
15
+ {"rl_step": 70, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 566.3128151893616, "cell_type": "Mic", "edit_type": "cell_type_transfer", "target_tf": "SOX6", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
16
+ {"rl_step": 75, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 606.376867055893, "cell_type": "Mic", "edit_type": "cell_type_transfer", "target_tf": "MYRF", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
17
+ {"rl_step": 80, "loss": 2.9802322387695312e-08, "mean_return": 0.40862005949020386, "max_return": 0.9414801597595215, "mean_motif_chained": 0.40862003735025, "gnorm": 2.8194335754960775e-10, "elapsed_s": 646.7227599620819, "cell_type": "Ex", "edit_type": "cell_type_transfer", "target_tf": "MYRF", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": -2.9802322387695312e-08, "adv_std": 0.9999978542327881, "adv_min": -0.8466768860816956, "adv_max": 1.104107141494751, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.40862003735025, "comp_kd_mean": 0.0, "comp_total_mean": 0.40862003735025, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
18
+ {"rl_step": 85, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 687.3371155261993, "cell_type": "Oli", "edit_type": "activity_boost", "target_tf": "OLIG2", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
19
+ {"rl_step": 90, "loss": 1.4901161193847656e-08, "mean_return": 0.17499999701976776, "max_return": 0.699999988079071, "mean_motif_chained": 0.175, "gnorm": 3.601599019020796e-10, "elapsed_s": 727.772115945816, "cell_type": "In", "edit_type": "activity_boost", "target_tf": "SOX6", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": -1.4901161193847656e-08, "adv_std": 0.9999970197677612, "adv_min": -0.499998539686203, "adv_max": 1.4999955892562866, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.175, "comp_kd_mean": 0.0, "comp_total_mean": 0.175, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
20
+ {"rl_step": 95, "loss": 0.0, "mean_return": 0.6624484658241272, "max_return": 1.3316550254821777, "mean_motif_chained": 0.6624484554999465, "gnorm": 3.7834979593753815e-10, "elapsed_s": 768.3619821071625, "cell_type": "End", "edit_type": "promoter_retarget", "target_tf": "KLF2", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.9999986886978149, "adv_min": -0.8660017251968384, "adv_max": 0.8748363852500916, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.6624484554999465, "comp_kd_mean": 0.0, "comp_total_mean": 0.6624484554999465, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
21
+ {"rl_step": 100, "loss": -4.470348358154297e-08, "mean_return": 0.5473381280899048, "max_return": 1.607173204421997, "mean_motif_chained": 0.54733814608275, "gnorm": 3.838067641481757e-10, "elapsed_s": 808.7525985240936, "cell_type": "OPC", "edit_type": "cell_type_transfer", "target_tf": "FLI1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 4.470348358154297e-08, "adv_std": 0.9999986886978149, "adv_min": -0.7220955491065979, "adv_max": 1.3982256650924683, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.54733814608275, "comp_kd_mean": 0.0, "comp_total_mean": 0.54733814608275, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
22
+ {"rl_step": 105, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 909.8289926052094, "cell_type": "Ex", "edit_type": "activity_boost", "target_tf": "TBR1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
23
+ {"rl_step": 110, "loss": -2.9802322387695312e-08, "mean_return": 0.38425779342651367, "max_return": 0.7762392163276672, "mean_motif_chained": 0.38425780998000003, "gnorm": 4.729372449219227e-10, "elapsed_s": 952.1637613773346, "cell_type": "Mic", "edit_type": "activity_boost", "target_tf": "CEBPA", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 2.9802322387695312e-08, "adv_std": 0.999997615814209, "adv_min": -0.8659359216690063, "adv_max": 0.8833413124084473, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.38425780998000003, "comp_kd_mean": 0.0, "comp_total_mean": 0.38425780998000003, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
24
+ {"rl_step": 115, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 995.5801725387573, "cell_type": "Ast", "edit_type": "promoter_retarget", "target_tf": "AP1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
25
+ {"rl_step": 120, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 1038.2237749099731, "cell_type": "Ast", "edit_type": "cell_type_transfer", "target_tf": "TBR1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
26
+ {"rl_step": 125, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 1079.600789308548, "cell_type": "Mic", "edit_type": "activity_boost", "target_tf": "CEBPA", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
27
+ {"rl_step": 130, "loss": 1.4901161193847656e-08, "mean_return": 0.148499995470047, "max_return": 0.593999981880188, "mean_motif_chained": 0.1485, "gnorm": 5.820766091346741e-10, "elapsed_s": 1125.4580965042114, "cell_type": "Ast", "edit_type": "promoter_retarget", "target_tf": "AP1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": -1.4901161193847656e-08, "adv_std": 0.999996542930603, "adv_min": -0.4999983012676239, "adv_max": 1.4999948740005493, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.1485, "comp_kd_mean": 0.0, "comp_total_mean": 0.1485, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
28
+ {"rl_step": 135, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 1169.3935053348541, "cell_type": "Ast", "edit_type": "promoter_retarget", "target_tf": "STAT3", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
29
+ {"rl_step": 140, "loss": -5.960464477539063e-08, "mean_return": 0.31177401542663574, "max_return": 0.6590360999107361, "mean_motif_chained": 0.31177402614517497, "gnorm": 1.5279510989785194e-10, "elapsed_s": 1956.5434894561768, "cell_type": "Ex", "edit_type": "promoter_retarget", "target_tf": "TBR1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 5.960464477539063e-08, "adv_std": 0.9999971985816956, "adv_min": -0.863231360912323, "adv_max": 0.9614897966384888, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.31177402614517497, "comp_kd_mean": 0.0, "comp_total_mean": 0.31177402614517497, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
30
+ {"rl_step": 145, "loss": 1.4901161193847656e-08, "mean_return": 0.40517234802246094, "max_return": 1.6206893920898438, "mean_motif_chained": 0.40517236235025, "gnorm": 3.0377123039215803e-10, "elapsed_s": 1996.5944757461548, "cell_type": "Oli", "edit_type": "cell_type_transfer", "target_tf": "ASCL1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": -1.4901161193847656e-08, "adv_std": 0.9999986886978149, "adv_min": -0.49999937415122986, "adv_max": 1.4999980926513672, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.40517236235025, "comp_kd_mean": 0.0, "comp_total_mean": 0.40517236235025, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
31
+ {"rl_step": 150, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 2036.2392945289612, "cell_type": "Ex", "edit_type": "activity_boost", "target_tf": "RORB", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
32
+ {"rl_step": 155, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 2082.9397311210632, "cell_type": "Ex", "edit_type": "promoter_retarget", "target_tf": "RORB", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
33
+ {"rl_step": 160, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 2122.689302444458, "cell_type": "Ast", "edit_type": "activity_boost", "target_tf": "NFIA", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
34
+ {"rl_step": 165, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 2165.747225999832, "cell_type": "OPC", "edit_type": "cell_type_transfer", "target_tf": "SPI1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
35
+ {"rl_step": 170, "loss": 0.0, "mean_return": 0.16311143338680267, "max_return": 0.6524457335472107, "mean_motif_chained": 0.16311143588372323, "gnorm": 9.677023626863956e-10, "elapsed_s": 2205.5136301517487, "cell_type": "In", "edit_type": "promoter_retarget", "target_tf": "DLX2", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.9999969005584717, "adv_min": -0.49999845027923584, "adv_max": 1.4999953508377075, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.16311143588372323, "comp_kd_mean": 0.0, "comp_total_mean": 0.16311143588372323, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
36
+ {"rl_step": 175, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 2250.854704618454, "cell_type": "In", "edit_type": "promoter_retarget", "target_tf": "LHX6", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
37
+ {"rl_step": 180, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 2290.46746301651, "cell_type": "Ex", "edit_type": "cell_type_transfer", "target_tf": "RUNX1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
38
+ {"rl_step": 185, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 2335.7854750156403, "cell_type": "Mic", "edit_type": "activity_boost", "target_tf": "RUNX1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
39
+ {"rl_step": 190, "loss": 2.9802322387695312e-08, "mean_return": 0.4082533121109009, "max_return": 0.9605960249900818, "mean_motif_chained": 0.40825330424999995, "gnorm": 3.510649548843503e-10, "elapsed_s": 2375.584857225418, "cell_type": "Oli", "edit_type": "cell_type_transfer", "target_tf": "RUNX1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": -2.9802322387695312e-08, "adv_std": 0.9999979138374329, "adv_min": -0.8402518630027771, "adv_max": 1.1368112564086914, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.40825330424999995, "comp_kd_mean": 0.0, "comp_total_mean": 0.40825330424999995, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
40
+ {"rl_step": 195, "loss": 1.4901161193847656e-08, "mean_return": 0.24014900624752045, "max_return": 0.9605960249900818, "mean_motif_chained": 0.2401490025, "gnorm": 1.1059455573558807e-09, "elapsed_s": 2647.7389798164368, "cell_type": "Ex", "edit_type": "cell_type_transfer", "target_tf": "AP1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": -1.4901161193847656e-08, "adv_std": 0.9999978542327881, "adv_min": -0.49999895691871643, "adv_max": 1.4999967813491821, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.2401490025, "comp_kd_mean": 0.0, "comp_total_mean": 0.2401490025, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
41
+ {"rl_step": 200, "loss": -5.960464477539063e-08, "mean_return": 0.4034743309020996, "max_return": 0.9414801597595215, "mean_motif_chained": 0.40347433910025, "gnorm": 2.6921043172478676e-10, "elapsed_s": 2688.212312936783, "cell_type": "Ex", "edit_type": "activity_boost", "target_tf": "NEUROD2", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 5.960464477539063e-08, "adv_std": 0.9999978542327881, "adv_min": -0.8429121971130371, "adv_max": 1.1239666938781738, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.40347433910025, "comp_kd_mean": 0.0, "comp_total_mean": 0.40347433910025, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
42
+ {"rl_step": 205, "loss": -5.960464477539063e-08, "mean_return": 0.552117109298706, "max_return": 0.9605960249900818, "mean_motif_chained": 0.5521171112325, "gnorm": 3.1650415621697903e-10, "elapsed_s": 2732.595745563507, "cell_type": "Ex", "edit_type": "cell_type_transfer", "target_tf": "SOX9", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 5.960464477539063e-08, "adv_std": 0.9999974966049194, "adv_min": -1.3724606037139893, "adv_max": 1.0154027938842773, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.5521171112325, "comp_kd_mean": 0.0, "comp_total_mean": 0.5521171112325, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
43
+ {"rl_step": 210, "loss": 0.0, "mean_return": 0.16311143338680267, "max_return": 0.6524457335472107, "mean_motif_chained": 0.16311143588372323, "gnorm": 1.5552359400317073e-10, "elapsed_s": 2772.408837556839, "cell_type": "Oli", "edit_type": "promoter_retarget", "target_tf": "MYRF", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.9999969005584717, "adv_min": -0.49999845027923584, "adv_max": 1.4999953508377075, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.16311143588372323, "comp_kd_mean": 0.0, "comp_total_mean": 0.16311143588372323, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
44
+ {"rl_step": 215, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 2812.2946326732635, "cell_type": "OPC", "edit_type": "promoter_retarget", "target_tf": "ASCL1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
45
+ {"rl_step": 220, "loss": 0.0, "mean_return": 0.23774750530719757, "max_return": 0.9509900212287903, "mean_motif_chained": 0.23774751247499998, "gnorm": 1.3005774235352874e-10, "elapsed_s": 2852.033831357956, "cell_type": "Oli", "edit_type": "cell_type_transfer", "target_tf": "SOX10", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.9999978542327881, "adv_min": -0.49999892711639404, "adv_max": 1.4999967813491821, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.23774751247499998, "comp_kd_mean": 0.0, "comp_total_mean": 0.23774751247499998, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
46
+ {"rl_step": 225, "loss": 2.9802322387695312e-08, "mean_return": 0.23301634192466736, "max_return": 0.9320653676986694, "mean_motif_chained": 0.23301633697674748, "gnorm": 2.419255906715989e-10, "elapsed_s": 2892.096002101898, "cell_type": "Oli", "edit_type": "cell_type_transfer", "target_tf": "TBR1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": -2.9802322387695312e-08, "adv_std": 0.9999977350234985, "adv_min": -0.49999892711639404, "adv_max": 1.4999966621398926, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.23301633697674748, "comp_kd_mean": 0.0, "comp_total_mean": 0.23301633697674748, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
47
+ {"rl_step": 230, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 2932.211152076721, "cell_type": "Mic", "edit_type": "promoter_retarget", "target_tf": "IRF8", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
48
+ {"rl_step": 235, "loss": 1.4901161193847656e-08, "mean_return": 0.148499995470047, "max_return": 0.593999981880188, "mean_motif_chained": 0.1485, "gnorm": 8.039933163672686e-10, "elapsed_s": 2972.0125873088837, "cell_type": "Ex", "edit_type": "cell_type_transfer", "target_tf": "SOX9", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": -1.4901161193847656e-08, "adv_std": 0.999996542930603, "adv_min": -0.4999983012676239, "adv_max": 1.4999948740005493, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.1485, "comp_kd_mean": 0.0, "comp_total_mean": 0.1485, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
49
+ {"rl_step": 240, "loss": 0.0, "mean_return": 0.23537003993988037, "max_return": 0.9414801597595215, "mean_motif_chained": 0.23537003735025, "gnorm": 5.311449058353901e-10, "elapsed_s": 3011.6724331378937, "cell_type": "In", "edit_type": "cell_type_transfer", "target_tf": "ASCL1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.9999978542327881, "adv_min": -0.49999892711639404, "adv_max": 1.4999967813491821, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.23537003735025, "comp_kd_mean": 0.0, "comp_total_mean": 0.23537003735025, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
50
+ {"rl_step": 245, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 3051.772312641144, "cell_type": "Oli", "edit_type": "cell_type_transfer", "target_tf": "SOX17", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
51
+ {"rl_step": 250, "loss": 1.4901161193847656e-08, "mean_return": 0.148499995470047, "max_return": 0.593999981880188, "mean_motif_chained": 0.1485, "gnorm": 3.0377123039215803e-10, "elapsed_s": 3091.5858783721924, "cell_type": "Ex", "edit_type": "promoter_retarget", "target_tf": "MEF2C", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": -1.4901161193847656e-08, "adv_std": 0.999996542930603, "adv_min": -0.4999983012676239, "adv_max": 1.4999948740005493, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.1485, "comp_kd_mean": 0.0, "comp_total_mean": 0.1485, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
52
+ {"rl_step": 255, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 3132.1977968215942, "cell_type": "Mic", "edit_type": "cell_type_transfer", "target_tf": "SOX6", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
53
+ {"rl_step": 260, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 3171.8211331367493, "cell_type": "Ex", "edit_type": "cell_type_transfer", "target_tf": "MYRF", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
54
+ {"rl_step": 265, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 3211.5899662971497, "cell_type": "Ast", "edit_type": "activity_boost", "target_tf": "AP1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
55
+ {"rl_step": 270, "loss": 1.4901161193847656e-08, "mean_return": 0.1732500046491623, "max_return": 0.6930000185966492, "mean_motif_chained": 0.17325, "gnorm": 3.255991032347083e-10, "elapsed_s": 3251.9206805229187, "cell_type": "Oli", "edit_type": "promoter_retarget", "target_tf": "MYRF", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": -1.4901161193847656e-08, "adv_std": 0.9999970197677612, "adv_min": -0.499998539686203, "adv_max": 1.4999955892562866, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.17325, "comp_kd_mean": 0.0, "comp_total_mean": 0.17325, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
56
+ {"rl_step": 275, "loss": -1.4901161193847656e-08, "mean_return": 0.1715175062417984, "max_return": 0.6860700249671936, "mean_motif_chained": 0.1715175, "gnorm": 4.874891601502895e-10, "elapsed_s": 3292.4477276802063, "cell_type": "OPC", "edit_type": "promoter_retarget", "target_tf": "SOX10", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 1.4901161193847656e-08, "adv_std": 0.9999970197677612, "adv_min": -0.4999985098838806, "adv_max": 1.4999955892562866, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.1715175, "comp_kd_mean": 0.0, "comp_total_mean": 0.1715175, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
57
+ {"rl_step": 280, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 3333.0772910118103, "cell_type": "Ast", "edit_type": "cell_type_transfer", "target_tf": "DLX1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
58
+ {"rl_step": 285, "loss": 0.0, "mean_return": 0.33620861172676086, "max_return": 0.6724172234535217, "mean_motif_chained": 0.3362086035, "gnorm": 9.74978320300579e-10, "elapsed_s": 3373.5622174739838, "cell_type": "Ex", "edit_type": "cell_type_transfer", "target_tf": "RUNX1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.9999973773956299, "adv_min": -0.8660231232643127, "adv_max": 0.8660231232643127, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.3362086035, "comp_kd_mean": 0.0, "comp_total_mean": 0.3362086035, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
59
+ {"rl_step": 290, "loss": 1.4901161193847656e-08, "mean_return": 0.148499995470047, "max_return": 0.593999981880188, "mean_motif_chained": 0.1485, "gnorm": 1.0695657692849636e-09, "elapsed_s": 3414.1426475048065, "cell_type": "Ast", "edit_type": "promoter_retarget", "target_tf": "AP1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": -1.4901161193847656e-08, "adv_std": 0.999996542930603, "adv_min": -0.4999983012676239, "adv_max": 1.4999948740005493, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.1485, "comp_kd_mean": 0.0, "comp_total_mean": 0.1485, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
60
+ {"rl_step": 295, "loss": 1.4901161193847656e-08, "mean_return": 0.24014900624752045, "max_return": 0.9605960249900818, "mean_motif_chained": 0.2401490025, "gnorm": 2.8194335754960775e-10, "elapsed_s": 3454.61288690567, "cell_type": "Ex", "edit_type": "promoter_retarget", "target_tf": "TBR1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": -1.4901161193847656e-08, "adv_std": 0.9999978542327881, "adv_min": -0.49999895691871643, "adv_max": 1.4999967813491821, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.2401490025, "comp_kd_mean": 0.0, "comp_total_mean": 0.2401490025, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
61
+ {"rl_step": 300, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 3494.750963449478, "cell_type": "Mic", "edit_type": "activity_boost", "target_tf": "CEBPA", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
62
+ {"rl_step": 305, "loss": 0.0, "mean_return": 0.3312157392501831, "max_return": 0.6724172234535217, "mean_motif_chained": 0.33121573763372325, "gnorm": 4.4929038267582655e-10, "elapsed_s": 3538.8187444210052, "cell_type": "OPC", "edit_type": "activity_boost", "target_tf": "ASCL1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.9999973177909851, "adv_min": -0.8658263683319092, "adv_max": 0.8919299840927124, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.33121573763372325, "comp_kd_mean": 0.0, "comp_total_mean": 0.33121573763372325, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
63
+ {"rl_step": 310, "loss": 2.9802322387695312e-08, "mean_return": 0.23301634192466736, "max_return": 0.9320653676986694, "mean_motif_chained": 0.23301633697674748, "gnorm": 1.964508555829525e-10, "elapsed_s": 3579.2918763160706, "cell_type": "In", "edit_type": "promoter_retarget", "target_tf": "DLX1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": -2.9802322387695312e-08, "adv_std": 0.9999977350234985, "adv_min": -0.49999892711639404, "adv_max": 1.4999966621398926, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.23301633697674748, "comp_kd_mean": 0.0, "comp_total_mean": 0.23301633697674748, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
64
+ {"rl_step": 315, "loss": 0.0, "mean_return": 0.23774750530719757, "max_return": 0.9509900212287903, "mean_motif_chained": 0.23774751247499998, "gnorm": 4.1654857341200113e-10, "elapsed_s": 3619.6829164028168, "cell_type": "Ex", "edit_type": "cell_type_transfer", "target_tf": "NKX2-2", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.9999978542327881, "adv_min": -0.49999892711639404, "adv_max": 1.4999967813491821, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.23774751247499998, "comp_kd_mean": 0.0, "comp_total_mean": 0.23774751247499998, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
65
+ {"rl_step": 320, "loss": -1.4901161193847656e-08, "mean_return": 0.16980232298374176, "max_return": 0.679209291934967, "mean_motif_chained": 0.169802325, "gnorm": 4.4565240386873484e-10, "elapsed_s": 3662.484307527542, "cell_type": "Ex", "edit_type": "cell_type_transfer", "target_tf": "NFIA", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 1.4901161193847656e-08, "adv_std": 0.9999970197677612, "adv_min": -0.4999985098838806, "adv_max": 1.4999955892562866, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.169802325, "comp_kd_mean": 0.0, "comp_total_mean": 0.169802325, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
66
+ {"rl_step": 325, "loss": 0.0, "mean_return": 0.4851740002632141, "max_return": 0.9800999760627747, "mean_motif_chained": 0.4851740025, "gnorm": 6.548361852765083e-10, "elapsed_s": 3702.0711994171143, "cell_type": "In", "edit_type": "promoter_retarget", "target_tf": "SOX6", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.9999982118606567, "adv_min": -0.8659363985061646, "adv_max": 0.8833417296409607, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.4851740025, "comp_kd_mean": 0.0, "comp_total_mean": 0.4851740025, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
67
+ {"rl_step": 330, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 3746.2241797447205, "cell_type": "Mic", "edit_type": "promoter_retarget", "target_tf": "IRF8", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
68
+ {"rl_step": 335, "loss": 0.0, "mean_return": 0.23774750530719757, "max_return": 0.9509900212287903, "mean_motif_chained": 0.23774751247499998, "gnorm": 6.220943760126829e-10, "elapsed_s": 3786.521364212036, "cell_type": "Ex", "edit_type": "promoter_retarget", "target_tf": "TBR1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.9999978542327881, "adv_min": -0.49999892711639404, "adv_max": 1.4999967813491821, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.23774751247499998, "comp_kd_mean": 0.0, "comp_total_mean": 0.23774751247499998, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
69
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70
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71
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72
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73
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74
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75
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76
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77
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78
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79
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80
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81
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82
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83
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84
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85
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86
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87
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88
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89
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90
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91
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92
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93
+ {"rl_step": 460, "loss": 0.0, "mean_return": 0.5743361711502075, "max_return": 1.6181353330612183, "mean_motif_chained": 0.5743361619767475, "gnorm": 4.802132025361061e-10, "elapsed_s": 6164.216342449188, "cell_type": "In", "edit_type": "cell_type_transfer", "target_tf": "MEF2C", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.9999986886978149, "adv_min": -0.7497912645339966, "adv_max": 1.3626714944839478, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.5743361619767475, "comp_kd_mean": 0.0, "comp_total_mean": 0.5743361619767475, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
94
+ {"rl_step": 465, "loss": -1.4901161193847656e-08, "mean_return": 0.25, "max_return": 1.0, "mean_motif_chained": 0.25, "gnorm": 4.4929038267582655e-10, "elapsed_s": 6204.651430130005, "cell_type": "Mic", "edit_type": "promoter_retarget", "target_tf": "RUNX1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 1.4901161193847656e-08, "adv_std": 0.9999979734420776, "adv_min": -0.4999989867210388, "adv_max": 1.4999970197677612, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.25, "comp_kd_mean": 0.0, "comp_total_mean": 0.25, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
95
+ {"rl_step": 470, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 6245.013745069504, "cell_type": "OPC", "edit_type": "promoter_retarget", "target_tf": "OLIG2", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
96
+ {"rl_step": 475, "loss": -1.4901161193847656e-08, "mean_return": 0.38621801137924194, "max_return": 0.7840800285339355, "mean_motif_chained": 0.38621800998, "gnorm": 2.382876118645072e-10, "elapsed_s": 6285.549707651138, "cell_type": "Mic", "edit_type": "cell_type_transfer", "target_tf": "SOX9", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 1.4901161193847656e-08, "adv_std": 0.9999976754188538, "adv_min": -0.8658266663551331, "adv_max": 0.891930341720581, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.38621800998, "comp_kd_mean": 0.0, "comp_total_mean": 0.38621800998, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
97
+ {"rl_step": 480, "loss": 0.0, "mean_return": 0.30292123556137085, "max_return": 1.2116849422454834, "mean_motif_chained": 0.30292123806977167, "gnorm": 2.0827428670600057e-10, "elapsed_s": 6325.703624010086, "cell_type": "OPC", "edit_type": "promoter_retarget", "target_tf": "ASCL1", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.9999983310699463, "adv_min": -0.49999916553497314, "adv_max": 1.4999974966049194, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.30292123806977167, "comp_kd_mean": 0.0, "comp_total_mean": 0.30292123806977167, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
98
+ {"rl_step": 485, "loss": -1.4901161193847656e-08, "mean_return": 0.3397590219974518, "max_return": 1.3590360879898071, "mean_motif_chained": 0.33975902614517495, "gnorm": 6.366462912410498e-10, "elapsed_s": 6365.4665541648865, "cell_type": "Oli", "edit_type": "activity_boost", "target_tf": "NKX2-2", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 1.4901161193847656e-08, "adv_std": 0.9999985694885254, "adv_min": -0.4999992549419403, "adv_max": 1.499997854232788, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.33975902614517495, "comp_kd_mean": 0.0, "comp_total_mean": 0.33975902614517495, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
99
+ {"rl_step": 490, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 6405.078861236572, "cell_type": "Oli", "edit_type": "promoter_retarget", "target_tf": "OLIG2", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
100
+ {"rl_step": 495, "loss": 0.0, "mean_return": 0.0, "max_return": 0.0, "mean_motif_chained": 0.0, "gnorm": 0.0, "elapsed_s": 6445.306855678558, "cell_type": "In", "edit_type": "activity_boost", "target_tf": "DLX2", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 0.0, "adv_std": 0.0, "adv_min": 0.0, "adv_max": 0.0, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.0, "comp_kd_mean": 0.0, "comp_total_mean": 0.0, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}
101
+ {"rl_step": 500, "loss": -1.4901161193847656e-08, "mean_return": 0.16810430586338043, "max_return": 0.6724172234535217, "mean_motif_chained": 0.16810430175, "gnorm": 4.638422979041934e-10, "elapsed_s": 6484.944807767868, "cell_type": "In", "edit_type": "activity_boost", "target_tf": "DLX2", "kd_active": false, "kd_tf": "", "kd_score_mean": 0.0, "ratio_mean": 1.0, "ratio_min": 1.0, "ratio_max": 1.0, "log_ratio_mean": 0.0, "adv_mean": 1.4901161193847656e-08, "adv_std": 0.9999969601631165, "adv_min": -0.4999984800815582, "adv_max": 1.499995470046997, "comp_oracle_mean": 0.0, "comp_motif_chained_mean": 0.16810430175, "comp_kd_mean": 0.0, "comp_total_mean": 0.16810430175, "_algo": "gspo", "_lora_r": 16, "_peak_lr": 1e-05, "_temperature": 1.0, "_seq_len_mean": 360.0}