| { |
| "description": "DeepECG-SSL fine-tuned in CLSA for incident CVD by Follow-up 2 (median 5.8 y). Ensemble of 5 cross-validation fold models.", |
| "input": { |
| "leads": 12, |
| "sampling_rate_hz": 250, |
| "duration_s": 10, |
| "samples": 2500, |
| "units": "mV", |
| "normalisation": "none (amplitude-preserving)", |
| "lead_order": "I, II, III, aVR, aVL, aVF, V1-V6" |
| }, |
| "per_fold_platt": { |
| "0": { |
| "a": 0.9256001662643487, |
| "b": -1.2964684731565865 |
| }, |
| "1": { |
| "a": 0.7505578577075713, |
| "b": -1.1098622868479822 |
| }, |
| "2": { |
| "a": 0.6849553209687097, |
| "b": -1.3305760314820416 |
| }, |
| "3": { |
| "a": 0.8646998199738609, |
| "b": -0.9854216020249019 |
| }, |
| "4": { |
| "a": 0.7763569971752428, |
| "b": -1.204451555024041 |
| } |
| }, |
| "model_A_plus": { |
| "formula": "logit(risk) = intercept + b_ecg*ecg_logit + b_age*age + b_female*female + b_htn*hypertension", |
| "intercept": -3.8386085094487012, |
| "b_ecg": 0.6502693992781706, |
| "b_age": 0.04871459335113484, |
| "b_female": -0.3648226286135894, |
| "b_htn": 0.34160917240450983, |
| "ecg_logit": "logit of the mean over folds of Platt-calibrated fold probabilities", |
| "age": "years", |
| "female": "1 if female", |
| "hypertension": "1 if self-reported physician-diagnosed hypertension" |
| }, |
| "model_ecg_age_sex_external": { |
| "formula": "logit(risk) = intercept + b_ecg*ecg_logit_uncal + b_age*age + b_female*female", |
| "intercept": -4.685164180420436, |
| "b_ecg": 0.5186974036163096, |
| "b_age": 0.052019636929571025, |
| "b_female": -0.3711663016453705, |
| "ecg_logit_uncal": "logit of the mean over the 5 folds of UNCALIBRATED fold sigmoid outputs", |
| "use": "validated at MHI (no hypertension variable); fitted on CLSA development out-of-fold predictions, applied unchanged. Overpredicts at MHI (slope 0.81, CITL -0.66): recalibrate locally." |
| }, |
| "age_sex_reference": { |
| "intercept": -6.624631360106959, |
| "b_age": 0.07239711085716635, |
| "b_female": -0.4616633628268495 |
| }, |
| "performance": { |
| "clsa_test_Aplus_auroc": "0.733 (0.707-0.759), n=3,906, 394 events", |
| "clsa_test_FRS_auroc": 0.689, |
| "clsa_test_PREVENT_auroc": 0.715, |
| "mhi_ecg_age_sex_auroc": "0.761 (0.751-0.771), n=21,647, 2,190 events; age+sex 0.728" |
| }, |
| "parameter_provenance": "Full-precision development-only logistic fits reproduced from the original recipe; every coefficient rounds to the original four-decimal coefficient; A+ verified against all 3906 saved test outputs." |
| } |
|
|
