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Oct 19

Pillar-0: A New Frontier for Radiology Foundation Models

Radiology plays an integral role in modern medicine, yet rising imaging volumes have far outpaced workforce growth. Foundation models offer a path toward assisting with the full spectrum of radiology tasks, but existing medical models remain limited: they process volumetric CT and MRI as low-fidelity 2D slices, discard critical grayscale contrast information, and lack evaluation frameworks that reflect real clinical practice. We introduce Pillar-0, a radiology foundation model pretrained on 42,990 abdomen-pelvis CTs, 86,411 chest CTs, 14,348 head CTs, and 11,543 breast MRIs from a large academic center, together with RATE, a scalable framework that extracts structured labels for 366 radiologic findings with near-perfect accuracy using LLMs. Across internal test sets of 14,230 abdomen-pelvis CTs, 10,646 chest CTs, 4,906 head CTs, and 1,585 breast MRIs, Pillar-0 establishes a new performance frontier, achieving mean AUROCs of 86.4, 88.0, 90.1, and 82.9, outperforming MedGemma (Google), MedImageInsight (Microsoft), Lingshu (Alibaba), and Merlin (Stanford) by 7.8-15.8 AUROC points and ranking best in 87.2\% (319/366) tasks. Pillar-0 similarly outperforms all baselines in an external validation on the Stanford Abdominal CT dataset, including Merlin (82.2 vs 80.6 AUROC). Pillar-0 extends to tasks beyond its pretraining, such as long-horizon lung cancer risk prediction, where it improves upon the state-of-the-art Sybil by 3.0 C-index points on NLST, and generalizes with gains of 5.9 (MGH) and 1.9 (CGMH). In brain hemorrhage detection, Pillar-0 obtained a >95 AUROC when using only 1/20th of the data of the next most sample efficient baseline. Pillar-0 and RATE together provide an open, clinically rigorous foundation for building high-performance radiology systems, enabling applications that were previously infeasible due to computational, data, and evaluation constraints.

YalaLab Yala Lab
·
Nov 21, 2025 2

SN 2023ixf in the Pinwheel Galaxy M101: From Shock Breakout to the Nebular Phase

We present photometric and spectroscopic observations of SN 2023ixf covering from day one to 442 days after explosion. SN 2023ixf reached a peak V-band absolute magnitude of -18.2 pm 0.07, and light curves show that it is in the fast-decliner (IIL) subclass with a relatively short ``plateau'' phase (fewer than sim 70 days). Early-time spectra of SN 2023ixf exhibit strong, very narrow emission lines from ionized circumstellar matter (CSM), possibly indicating a Type IIn classification. But these flash/shock-ionization emission features faded after the first week and the spectrum evolved in a manner similar to that of typical Type II SNe, unlike the case of most genuine SNe~IIn in which the ejecta interact with CSM for an extended period of time and develop intermediate-width emission lines. We compare observed spectra of SN 2023ixf with various model spectra to understand the physics behind SN 2023ixf. Our nebular spectra (between 200-400 d) match best with the model spectra from a 15 rm M_{odot} progenitor which experienced enhanced mass loss a few years before explosion. A last-stage mass-loss rate of M = 0.01 rm M_{odot} yr^{-1} from the r1w6 model matches best with the early-time spectra, higher than M approx 2.4 times 10^{-3} rm M_{odot} yr^{-1} derived from the ionized H{alpha} luminosity at 1.58 d. We also use SN 2023ixf as a distance indicator and fit the light curves to derive the Hubble constant by adding SN 2023ixf to the existing sample; we obtain H_{0}=73.1^{+3.68}_{-3.50} km s^{-1} Mpc^{-1}, consistent with the results from SNe~Ia and many other independent methods.

  • 42 authors
·
Mar 18, 2025

Rounding in Preconditioner Space: Redesigning 4-bit AdamW Optimizer-State Quantization

Quantizing AdamW's optimizer states reduces persistent storage, but quantization errors propagate through the moment recurrences and perturb subsequent adaptive updates. We redesign 4-bit optimizer-state quantization for AdamW from the perspective of rounding space: the coordinate in which a quantizer chooses between adjacent reconstruction levels. For the second moment, a local analysis of the quantization cell adjacent to zero shows that small mean state error need not imply small mean preconditioner error at the next step. A one-dimensional quadratic construction further shows qualitatively different optimization dynamics under state-space and preconditioner-space rounding. These results motivate Zero-Inclusive Preconditioner-space Stochastic Rounding (ZIP-SR), which retains zero in the second-moment codebook and computes stochastic-rounding probabilities in preconditioner space. As a complementary route, Zero-Excluding EDEN calibration (ZE-EDEN) uses a zero-excluding second-moment codebook and rescales the quantized second-moment block to mitigate the preconditioner distortion caused by the positive quantization floor. Both configurations use 4-bit NormalFloat (NF4) for the first moment, with targeted stochastic rounding of the LM-head first moment during the final 10\% of training. Across GPT- and Llama-style pretraining experiments ranging from 130M to 2.7B parameters, both methods reduce TorchAO 4-bit AdamW's mean validation-loss gap to 32-bit AdamW at every evaluated model size, with the largest reported gap reduction reaching 70\%. In full-parameter supervised fine-tuning, both recipes achieve lower validation loss than TorchAO while remaining close to 32-bit AdamW on downstream tasks.

  • 10 authors
·
Oct 7