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Aug 3

AbBiBench: A Benchmark for Antibody Binding Affinity Maturation and Design

We introduce AbBiBench (Antibody Binding Benchmarking), a benchmarking framework for antibody binding affinity maturation and design. Unlike previous strategies that evaluate antibodies in isolation, typically by comparing them to natural sequences with metrics such as amino acid recovery rate or structural RMSD, AbBiBench instead treats the antibody-antigen (Ab-Ag) complex as the fundamental unit. It evaluates an antibody design's binding potential by measuring how well a protein model scores the full Ab-Ag complex. We first curate, standardize, and share more than 184,500 experimental measurements of antibody mutants across 14 antibodies and 9 antigens-including influenza, lysozyme, HER2, VEGF, integrin, Ang2, and SARS-CoV-2-covering both heavy-chain and light-chain mutations. Using these datasets, we systematically compare 15 protein models including masked language models, autoregressive language models, inverse folding models, diffusion-based generative models, and geometric graph models by comparing the correlation between model likelihood and experimental affinity values. Additionally, to demonstrate AbBiBench's generative utility, we apply it to antibody F045-092 in order to introduce binding to influenza H1N1. We sample new antibody variants with the top-performing models, rank them by the structural integrity and biophysical properties of the Ab-Ag complex, and assess them with in vitro ELISA binding assays. Our findings show that structure-conditioned inverse folding models outperform others in both affinity correlation and generation tasks. Overall, AbBiBench provides a unified, biologically grounded evaluation framework to facilitate the development of more effective, function-aware antibody design models.

  • 12 authors
·
May 23, 2025

Industrial Dexterity Benchmark: A Hardware-Software Benchmarking Platform for Industrial Dexterous Manipulation

Dexterous manipulation remains a critical bottleneck in industrial automation; tasks such as cable routing, connector insertion, and precision assembly still rely heavily on manual labor despite decades of robotics research. This work presents a progression from classical, modular robotics pipelines toward an end-to-end multimodal imitation-learning framework for industrial dexterous manipulation. As a part of this work, we introduce three key contributions: a set of Industrial Dexterity Benchmark (IDB) boards aimed to mimic datacenter cable management, automotive cable harnesses, and gearbox assembly tasks; a scalable imitation learning framework (DAG-ROS); and a multimodal diffusion-based policy framework (AG-iDP3) that creates models fusing RGB images, point clouds, joint positions, and wrist-frame wrench data. Focusing on the datacenter cable manipulation board, we evaluate the performance of a task involving cleaning a single cable over variations of an end-to-end AI policy using 48 trials per configuration. The best performing configuration, a multimodal expansion Diffusion Policy (DP), includes a multi-view RGB image source passed through an R3M encoder and reaches a 78% grasp and insert combined task success rate. This performance marks a significant improvement over the 36% observed from the single-camera RGB DP baseline. Each of the tested configurations requires only approximately 100 teleoperated demonstrations per task phase. These results indicate that the correct learned policy can outperform classical vision and control robotic methods in robustness, generalization, and deployment efficiency, justifying a shift toward scalable robotic automation for high up-time industrial environments.

  • 11 authors
·
Jul 14

Lipi Gnani - A Versatile OCR for Documents in any Language Printed in Kannada Script

A Kannada OCR, named Lipi Gnani, has been designed and developed from scratch, with the motivation of it being able to convert printed text or poetry in Kannada script, without any restriction on vocabulary. The training and test sets have been collected from over 35 books published between the period 1970 to 2002, and this includes books written in Halegannada and pages containing Sanskrit slokas written in Kannada script. The coverage of the OCR is nearly complete in the sense that it recognizes all the punctuation marks, special symbols, Indo-Arabic and Kannada numerals and also the interspersed English words. Several minor and major original contributions have been done in developing this OCR at the different processing stages such as binarization, line and character segmentation, recognition and Unicode mapping. This has created a Kannada OCR that performs as good as, and in some cases, better than the Google's Tesseract OCR, as shown by the results. To the knowledge of the authors, this is the maiden report of a complete Kannada OCR, handling all the issues involved. Currently, there is no dictionary based postprocessing, and the obtained results are due solely to the recognition process. Four benchmark test databases containing scanned pages from books in Kannada, Sanskrit, Konkani and Tulu languages, but all of them printed in Kannada script, have been created. The word level recognition accuracy of Lipi Gnani is 4% higher on the Kannada dataset than that of Google's Tesseract OCR, 8% higher on the datasets of Tulu and Sanskrit, and 25% higher on the Konkani dataset.

  • 2 authors
·
Jan 1, 2019

GI-GS: Global Illumination Decomposition on Gaussian Splatting for Inverse Rendering

We present GI-GS, a novel inverse rendering framework that leverages 3D Gaussian Splatting (3DGS) and deferred shading to achieve photo-realistic novel view synthesis and relighting. In inverse rendering, accurately modeling the shading processes of objects is essential for achieving high-fidelity results. Therefore, it is critical to incorporate global illumination to account for indirect lighting that reaches an object after multiple bounces across the scene. Previous 3DGS-based methods have attempted to model indirect lighting by characterizing indirect illumination as learnable lighting volumes or additional attributes of each Gaussian, while using baked occlusion to represent shadow effects. These methods, however, fail to accurately model the complex physical interactions between light and objects, making it impossible to construct realistic indirect illumination during relighting. To address this limitation, we propose to calculate indirect lighting using efficient path tracing with deferred shading. In our framework, we first render a G-buffer to capture the detailed geometry and material properties of the scene. Then, we perform physically-based rendering (PBR) only for direct lighting. With the G-buffer and previous rendering results, the indirect lighting can be calculated through a lightweight path tracing. Our method effectively models indirect lighting under any given lighting conditions, thereby achieving better novel view synthesis and relighting. Quantitative and qualitative results show that our GI-GS outperforms existing baselines in both rendering quality and efficiency.

  • 3 authors
·
Oct 3, 2024