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Aug 4

BiPFT: Binary Pre-trained Foundation Transformer with Low-rank Estimation of Binarization Residual Polynomials

Pretrained foundation models offer substantial benefits for a wide range of downstream tasks, which can be one of the most potential techniques to access artificial general intelligence. However, scaling up foundation transformers for maximal task-agnostic knowledge has brought about computational challenges, especially on resource-limited devices such as mobiles. This work proposes the first Binary Pretrained Foundation Transformer (BiPFT) for natural language understanding (NLU) tasks, which remarkably saves 56 times operations and 28 times memory. In contrast to previous task-specific binary transformers, BiPFT exhibits a substantial enhancement in the learning capabilities of binary neural networks (BNNs), promoting BNNs into the era of pre-training. Benefiting from extensive pretraining data, we further propose a data-driven binarization method. Specifically, we first analyze the binarization error in self-attention operations and derive the polynomials of binarization error. To simulate full-precision self-attention, we define binarization error as binarization residual polynomials, and then introduce low-rank estimators to model these polynomials. Extensive experiments validate the effectiveness of BiPFTs, surpassing task-specific baseline by 15.4% average performance on the GLUE benchmark. BiPFT also demonstrates improved robustness to hyperparameter changes, improved optimization efficiency, and reduced reliance on downstream distillation, which consequently generalize on various NLU tasks and simplify the downstream pipeline of BNNs. Our code and pretrained models are publicly available at https://github.com/Xingrun-Xing/BiPFT.

  • 7 authors
·
Dec 14, 2023

Dinomaly: The Less Is More Philosophy in Multi-Class Unsupervised Anomaly Detection

Recent studies highlighted a practical setting of unsupervised anomaly detection (UAD) that builds a unified model for multi-class images. Despite various advancements addressing this challenging task, the detection performance under the multi-class setting still lags far behind state-of-the-art class-separated models. Our research aims to bridge this substantial performance gap. In this paper, we introduce a minimalistic reconstruction-based anomaly detection framework, namely Dinomaly, which leverages pure Transformer architectures without relying on complex designs, additional modules, or specialized tricks. Given this powerful framework consisted of only Attentions and MLPs, we found four simple components that are essential to multi-class anomaly detection: (1) Foundation Transformers that extracts universal and discriminative features, (2) Noisy Bottleneck where pre-existing Dropouts do all the noise injection tricks, (3) Linear Attention that naturally cannot focus, and (4) Loose Reconstruction that does not force layer-to-layer and point-by-point reconstruction. Extensive experiments are conducted across popular anomaly detection benchmarks including MVTec-AD, VisA, and Real-IAD. Our proposed Dinomaly achieves impressive image-level AUROC of 99.6%, 98.7%, and 89.3% on the three datasets respectively, which is not only superior to state-of-the-art multi-class UAD methods, but also achieves the most advanced class-separated UAD records.

  • 6 authors
·
May 23, 2024

HydroGEM: A Self Supervised Zero Shot Hybrid TCN Transformer Foundation Model for Continental Scale Streamflow Quality Control

Real-time streamflow monitoring networks generate millions of observations annually, yet maintaining data quality across thousands of remote sensors remains labor-intensive. We introduce HydroGEM (Hydrological Generalizable Encoder for Monitoring), a foundation model for continental-scale streamflow quality control. HydroGEM uses two-stage training: self-supervised pretraining on 6.03 million sequences from 3,724 USGS stations learns hydrological representations, followed by fine-tuning with synthetic anomalies for detection and reconstruction. A hybrid TCN-Transformer architecture (14.2M parameters) captures local temporal patterns and long-range dependencies, while hierarchical normalization handles six orders of magnitude in discharge. On held-out synthetic tests comprising 799 stations with 18 expert-validated anomaly types, HydroGEM achieves F1 = 0.792 for detection and 68.7% reconstruction-error reduction, a 36.3% improvement over existing methods. Zero-shot transfer to 100 Environment and Climate Change Canada stations yields F1 = 0.586, exceeding all baselines and demonstrating cross-national generalization. The model maintains consistent detection across correction magnitudes and aligns with operational seasonal patterns. HydroGEM is designed for human-in-the-loop workflows - outputs are quality control suggestions requiring expert review, not autonomous corrections.

  • 4 authors
·
Dec 16, 2025

Hint-Aug: Drawing Hints from Foundation Vision Transformers Towards Boosted Few-Shot Parameter-Efficient Tuning

Despite the growing demand for tuning foundation vision transformers (FViTs) on downstream tasks, fully unleashing FViTs' potential under data-limited scenarios (e.g., few-shot tuning) remains a challenge due to FViTs' data-hungry nature. Common data augmentation techniques fall short in this context due to the limited features contained in the few-shot tuning data. To tackle this challenge, we first identify an opportunity for FViTs in few-shot tuning: pretrained FViTs themselves have already learned highly representative features from large-scale pretraining data, which are fully preserved during widely used parameter-efficient tuning. We thus hypothesize that leveraging those learned features to augment the tuning data can boost the effectiveness of few-shot FViT tuning. To this end, we propose a framework called Hint-based Data Augmentation (Hint-Aug), which aims to boost FViT in few-shot tuning by augmenting the over-fitted parts of tuning samples with the learned features of pretrained FViTs. Specifically, Hint-Aug integrates two key enablers: (1) an Attentive Over-fitting Detector (AOD) to detect over-confident patches of foundation ViTs for potentially alleviating their over-fitting on the few-shot tuning data and (2) a Confusion-based Feature Infusion (CFI) module to infuse easy-to-confuse features from the pretrained FViTs with the over-confident patches detected by the above AOD in order to enhance the feature diversity during tuning. Extensive experiments and ablation studies on five datasets and three parameter-efficient tuning techniques consistently validate Hint-Aug's effectiveness: 0.04% ~ 32.91% higher accuracy over the state-of-the-art (SOTA) data augmentation method under various low-shot settings. For example, on the Pet dataset, Hint-Aug achieves a 2.22% higher accuracy with 50% less training data over SOTA data augmentation methods.

  • 5 authors
·
Apr 24, 2023

TiMo: Spatiotemporal Foundation Model for Satellite Image Time Series

Satellite image time series (SITS) provide continuous observations of the Earth's surface, making them essential for applications such as environmental management and disaster assessment. However, existing spatiotemporal foundation models rely on plain vision transformers, which encode entire temporal sequences without explicitly capturing multiscale spatiotemporal relationships between land objects. This limitation hinders their effectiveness in downstream tasks. To overcome this challenge, we propose TiMo, a novel hierarchical vision transformer foundation model tailored for SITS analysis. At its core, we introduce a spatiotemporal gyroscope attention mechanism that dynamically captures evolving multiscale patterns across both time and space. For pre-training, we curate MillionST, a large-scale dataset of one million images from 100,000 geographic locations, each captured across 10 temporal phases over five years, encompassing diverse geospatial changes and seasonal variations. Leveraging this dataset, we adapt masked image modeling to pre-train TiMo, enabling it to effectively learn and encode generalizable spatiotemporal representations.Extensive experiments across multiple spatiotemporal tasks-including deforestation monitoring, land cover segmentation, crop type classification, and flood detection-demonstrate TiMo's superiority over state-of-the-art methods. Code, model, and dataset will be released at https://github.com/MiliLab/TiMo.

  • 7 authors
·
May 12, 2025

InstantCharacter: Personalize Any Characters with a Scalable Diffusion Transformer Framework

Current learning-based subject customization approaches, predominantly relying on U-Net architectures, suffer from limited generalization ability and compromised image quality. Meanwhile, optimization-based methods require subject-specific fine-tuning, which inevitably degrades textual controllability. To address these challenges, we propose InstantCharacter, a scalable framework for character customization built upon a foundation diffusion transformer. InstantCharacter demonstrates three fundamental advantages: first, it achieves open-domain personalization across diverse character appearances, poses, and styles while maintaining high-fidelity results. Second, the framework introduces a scalable adapter with stacked transformer encoders, which effectively processes open-domain character features and seamlessly interacts with the latent space of modern diffusion transformers. Third, to effectively train the framework, we construct a large-scale character dataset containing 10-million-level samples. The dataset is systematically organized into paired (multi-view character) and unpaired (text-image combinations) subsets. This dual-data structure enables simultaneous optimization of identity consistency and textual editability through distinct learning pathways. Qualitative experiments demonstrate the advanced capabilities of InstantCharacter in generating high-fidelity, text-controllable, and character-consistent images, setting a new benchmark for character-driven image generation. Our source code is available at https://github.com/Tencent/InstantCharacter.

  • 12 authors
·
Apr 16, 2025 2

TokaMind for Power Grid: Cross-Domain Transfer from Fusion Plasma

TokaMind is a multi-modal transformer (MMT) foundation model pre-trained on tokamak plasma diagnostics data from MAST, where it was shown to outperform CNN-based approaches on fusion benchmarks. We investigate whether its learned representations generalize to physically distinct but structurally analogous domains. Through systematic experimentation across four domains-industrial bearing degradation, NASA CMAPSS turbofan degradation, and two independent power grid PMU datasets-we identify four transfer-favoring characteristics that help explain where TokaMind's pretrained representations are most effective. Power grid synchrophasor data matches this target-domain profile most directly, while industrial degradation datasets demonstrate that TokaMind can still yield useful performance under partial alignment, especially when task design and feature construction expose physically meaningful degradation structure. On the GESL/PNNL 500-event benchmark with provider-aware evaluation, TokaMind achieves test F1 = 0.837 pm 0.040 (3~seeds) for severe event classification. Our central finding, however, is not the aggregate score: classification difficulty is structurally determined by provider-level grid topology, not model capacity. In the single-window early-warning regime, TokaMind outperforms a CNN baseline (F1~0.889 vs.~0.878)--a reversal that disappears as more event windows are provided. Furthermore, Critical Slowing Down (CSD) indicators, used as a confidence gate rather than a classification label, improve F1 from 0.696 to 0.750 at 63% coverage-outperforming the CNN baseline (0.636) at any coverage level. These results establish the first cross-domain validation of TokaMind outside nuclear fusion and propose a transferability framework and revised evaluation protocol for multi-source PMU datasets.

  • 3 authors
·
May 9

MEG-GPT: A transformer-based foundation model for magnetoencephalography data

Modelling the complex spatiotemporal patterns of large-scale brain dynamics is crucial for neuroscience, but traditional methods fail to capture the rich structure in modalities such as magnetoencephalography (MEG). Recent advances in deep learning have enabled significant progress in other domains, such as language and vision, by using foundation models at scale. Here, we introduce MEG-GPT, a transformer based foundation model that uses time-attention and next time-point prediction. To facilitate this, we also introduce a novel data-driven tokeniser for continuous MEG data, which preserves the high temporal resolution of continuous MEG signals without lossy transformations. We trained MEG-GPT on tokenised brain region time-courses extracted from a large-scale MEG dataset (N=612, eyes-closed rest, Cam-CAN data), and show that the learnt model can generate data with realistic spatio-spectral properties, including transient events and population variability. Critically, it performs well in downstream decoding tasks, improving downstream supervised prediction task, showing improved zero-shot generalisation across sessions (improving accuracy from 0.54 to 0.59) and subjects (improving accuracy from 0.41 to 0.49) compared to a baseline methods. Furthermore, we show the model can be efficiently fine-tuned on a smaller labelled dataset to boost performance in cross-subject decoding scenarios. This work establishes a powerful foundation model for electrophysiological data, paving the way for applications in computational neuroscience and neural decoding.

  • 5 authors
·
Oct 20, 2025

netFound: Foundation Model for Network Security

Developing generalizable ML-based solutions for disparate learning problems in network security is highly desired. However, despite a rich history of applying ML to network security, most existing solutions lack generalizability. This lack of progress can be attributed to an overreliance on supervised learning techniques and the associated challenges of curating well-specified labeled training data. This paper addresses a fundamental gap by introducing a novel transformer-based network foundation model, netFound. We employ self-supervised learning techniques on abundant, unlabeled network telemetry data for pre-training. This pretrained model can subsequently be fine-tuned to create generalizable learning artifacts for disparate learning tasks, even when using commonly available but challenging labeled datasets that are sparse, noisy, and skewed. To realize this goal, netFound leverages various domain-specific attributes and constraints unique to network data (packet traces) by developing multi-modal embeddings, protocol-aware tokenization, data-driven token composition, and hierarchical transformers. Our results demonstrate that netFound's domain-specific design choices ensure that it (1) effectively captures the hidden networking context in production settings, (2) outperforms four different SOTA methods on five different learning tasks, and (3) is robust to both noisy labels and learning shortcuts -- critical for developing generalizable ML models in practical settings.

  • 5 authors
·
Oct 25, 2023

On Realization of Intelligent Decision-Making in the Real World: A Foundation Decision Model Perspective

The pervasive uncertainty and dynamic nature of real-world environments present significant challenges for the widespread implementation of machine-driven Intelligent Decision-Making (IDM) systems. Consequently, IDM should possess the ability to continuously acquire new skills and effectively generalize across a broad range of applications. The advancement of Artificial General Intelligence (AGI) that transcends task and application boundaries is critical for enhancing IDM. Recent studies have extensively investigated the Transformer neural architecture as a foundational model for various tasks, including computer vision, natural language processing, and reinforcement learning. We propose that a Foundation Decision Model (FDM) can be developed by formulating diverse decision-making tasks as sequence decoding tasks using the Transformer architecture, offering a promising solution for expanding IDM applications in complex real-world situations. In this paper, we discuss the efficiency and generalization improvements offered by a foundation decision model for IDM and explore its potential applications in multi-agent game AI, production scheduling, and robotics tasks. Lastly, we present a case study demonstrating our FDM implementation, DigitalBrain (DB1) with 1.3 billion parameters, achieving human-level performance in 870 tasks, such as text generation, image captioning, video game playing, robotic control, and traveling salesman problems. As a foundation decision model, DB1 represents an initial step toward more autonomous and efficient real-world IDM applications.

  • 10 authors
·
Dec 24, 2022

MuSViT: A Foundation Vision Model for Sheet Music Representation

Foundation models have transformed vision and language processing by providing rich, reusable representations that transfer across diverse tasks. Sheet music, as a visual encoding of musical language, lacks such a strong domain-specific backbone. We introduce MuSViT (Music Score Vision Transformer): the first foundation vision model for sheet music representation -- a ViT encoder pre-trained via Masked Autoencoders on 9.7 million pages from the IMSLP. To handle the complexity of real-world scores, we adopt a two-stage curriculum: a synthetic warm-up on typeset scores followed by large-scale training on the full IMSLP corpus. We evaluate MuSViT on four downstream tasks -- full-page and staff-level music score recognition, music symbol detection, and score difficulty classification -- under two scenarios: linear probing (frozen encoder) and fine-tuning. Under linear probing, MuSViT consistently outperforms modern vision encoders, revealing that general-purpose representations, regardless of scale, fall systematically short on the structured symbolic properties of musical notation. Under fine-tuning, MuSViT generally improves upon task-specific state-of-the-art methods. An additional embedding-transcription consistency analysis reveals that MuSViT encodes symbolic musical structure directly in its representation space -- unlike other encoders, whose embeddings do not correlate with music notation content. These results establish MuSViT as a foundation backbone for sheet music understanding.

Vision Transformers for Zero-Shot Clustering of Animal Images: A Comparative Benchmarking Study

Manual labeling of animal images remains a significant bottleneck in ecological research, limiting the scale and efficiency of biodiversity monitoring efforts. This study investigates whether state-of-the-art Vision Transformer (ViT) foundation models can reduce thousands of unlabeled animal images directly to species-level clusters. We present a comprehensive benchmarking framework evaluating five ViT models combined with five dimensionality reduction techniques and four clustering algorithms, two supervised and two unsupervised, across 60 species (30 mammals and 30 birds), with each test using a random subset of 200 validated images per species. We investigate when clustering succeeds at species-level, where it fails, and whether clustering within the species-level reveals ecologically meaningful patterns such as sex, age, or phenotypic variation. Our results demonstrate near-perfect species-level clustering (V-measure: 0.958) using DINOv3 embeddings with t-SNE and supervised hierarchical clustering methods. Unsupervised approaches achieve competitive performance (0.943) while requiring no prior species knowledge, rejecting only 1.14% of images as outliers requiring expert review. We further demonstrate robustness to realistic long-tailed distributions of species and show that intentional over-clustering can reliably extract intra-specific variation including age classes, sexual dimorphism, and pelage differences. We introduce an open-source benchmarking toolkit and provide recommendations for ecologists to select appropriate methods for sorting their specific taxonomic groups and data.

  • 3 authors
·
Feb 3

SpectraFM: Tuning into Stellar Foundation Models

Machine learning models in astrophysics are often limited in scope and cannot adapt to data from new instruments or tasks. We introduce SpectraFM, a Transformer-based foundation model architecture that can be pre-trained on stellar spectra from any wavelength range and instrument. SpectraFM excels in generalization by combining flexibility with knowledge transfer from pre-training, allowing it to outperform traditional machine learning methods, especially in scenarios with limited training data. Our model is pre-trained on approximately 90k examples of synthetic spectra to predict the chemical abundances (Fe, Mg, O), temperature, and specific gravity of stars. We then fine-tune the model on real spectra to adapt it to observational data before fine-tuning it further on a restricted 100-star training set in a different wavelength range to predict iron abundance. Despite a small iron-rich training set of real spectra, transfer learning from the synthetic spectra pre-training enables the model to perform well on iron-poor stars. In contrast, a neural network trained from scratch fails at this task. We investigate the Transformer attention mechanism and find that the wavelengths receiving attention carry physical information about chemical composition. By leveraging the knowledge from pre-training and its ability to handle non-spectra inputs, SpectraFM reduces the need for large training datasets and enables cross-instrument and cross-domain research. Its adaptability makes it well-suited for tackling emerging challenges in astrophysics, like extracting insights from multi-modal datasets.

  • 2 authors
·
Nov 6, 2024

Sensing Cardiac Health Across Scenarios and Devices: A Multi-Modal Foundation Model Pretrained on Heterogeneous Data from 1.7 Million Individuals

Cardiac biosignals, such as electrocardiograms (ECG) and photoplethysmograms (PPG), are of paramount importance for the diagnosis, prevention, and management of cardiovascular diseases, and have been extensively used in a variety of clinical tasks. Conventional deep learning approaches for analyzing these signals typically rely on homogeneous datasets and static bespoke models, limiting their robustness and generalizability across diverse clinical settings and acquisition protocols. In this study, we present a cardiac sensing foundation model (CSFM) that leverages advanced transformer architectures and a generative, masked pretraining strategy to learn unified representations from vast, heterogeneous health records. Our model is pretrained on an innovative multi-modal integration of data from multiple large-scale datasets (including MIMIC-III-WDB, MIMIC-IV-ECG, and CODE), comprising cardiac signals and the corresponding clinical or machine-generated text reports from approximately 1.7 million individuals. We demonstrate that the embeddings derived from our CSFM not only serve as effective feature extractors across diverse cardiac sensing scenarios, but also enable seamless transfer learning across varying input configurations and sensor modalities. Extensive evaluations across diagnostic tasks, demographic information recognition, vital sign measurement, clinical outcome prediction, and ECG question answering reveal that CSFM consistently outperforms traditional one-modal-one-task approaches. Notably, CSFM exhibits robust performance across multiple ECG lead configurations from standard 12-lead systems to single-lead setups, and in scenarios where only ECG, only PPG, or a combination thereof is available. These findings highlight the potential of CSFM as a versatile and scalable solution, for comprehensive cardiac monitoring.

  • 13 authors
·
Jun 23, 2025

Scaling Self-Supervised and Cross-Modal Pretraining for Volumetric CT Transformers

We introduce SPECTRE, a fully transformer-based foundation model for volumetric computed tomography (CT). Our Self-Supervised & Cross-Modal Pretraining for CT Representation Extraction (SPECTRE) approach utilizes scalable 3D Vision Transformer architectures and modern self-supervised and vision-language pretraining strategies to learn general-purpose CT representations. Volumetric CT poses unique challenges, such as extreme token scaling, geometric anisotropy, and weak or noisy clinical supervision, that make standard transformer and contrastive learning recipes ineffective out of the box. The framework jointly optimizes a local transformer for high-resolution volumetric feature extraction and a global transformer for whole-scan context modeling, making large-scale 3D attention computationally tractable. Notably, SPECTRE is trained exclusively on openly available CT datasets, demonstrating that high-performing, generalizable representations can be achieved without relying on private data. Pretraining combines DINO-style self-distillation with SigLIP-based vision-language alignment using paired radiology reports, yielding features that are both geometrically consistent and clinically meaningful. Across multiple CT benchmarks, SPECTRE consistently outperforms prior CT foundation models in both zero-shot and fine-tuned settings, establishing SPECTRE as a scalable, open, and fully transformer-based foundation model for 3D medical imaging.

  • 5 authors
·
Mar 29

Memory-Efficient Acceleration of Block Low-Rank Foundation Models on Resource Constrained GPUs

Recent advances in transformer-based foundation models have made them the default choice for many tasks, but their rapidly growing size makes fitting a full model on a single GPU increasingly difficult and their computational cost prohibitive. Block low-rank (BLR) compression techniques address this challenge by learning compact representations of weight matrices. While traditional low-rank (LR) methods often incur sharp accuracy drops, BLR approaches such as Monarch and BLAST can better capture the underlying structure, thus preserving accuracy while reducing computations and memory footprints. In this work, we use roofline analysis to show that, although BLR methods achieve theoretical savings and practical speedups for single-token inference, multi-token inference often becomes memory-bound in practice, increasing latency despite compiler-level optimizations in PyTorch. To address this, we introduce custom Triton kernels with partial fusion and memory layout optimizations for both Monarch and BLAST. On memory-constrained NVIDIA GPUs such as Jetson Orin Nano and A40, our kernels deliver up to 3.76times speedups and 3times model size compression over PyTorch dense baselines using CUDA backend and compiler-level optimizations, while supporting various models including Llama-7/1B, GPT2-S, DiT-XL/2, and ViT-B. Our code is available at https://github.com/pabillam/mem-efficient-blr.

  • 6 authors
·
Jan 16

ViNT: A Foundation Model for Visual Navigation

General-purpose pre-trained models ("foundation models") have enabled practitioners to produce generalizable solutions for individual machine learning problems with datasets that are significantly smaller than those required for learning from scratch. Such models are typically trained on large and diverse datasets with weak supervision, consuming much more training data than is available for any individual downstream application. In this paper, we describe the Visual Navigation Transformer (ViNT), a foundation model that aims to bring the success of general-purpose pre-trained models to vision-based robotic navigation. ViNT is trained with a general goal-reaching objective that can be used with any navigation dataset, and employs a flexible Transformer-based architecture to learn navigational affordances and enable efficient adaptation to a variety of downstream navigational tasks. ViNT is trained on a number of existing navigation datasets, comprising hundreds of hours of robotic navigation from a variety of different robotic platforms, and exhibits positive transfer, outperforming specialist models trained on singular datasets. ViNT can be augmented with diffusion-based subgoal proposals to explore novel environments, and can solve kilometer-scale navigation problems when equipped with long-range heuristics. ViNT can also be adapted to novel task specifications with a technique inspired by prompt-tuning, where the goal encoder is replaced by an encoding of another task modality (e.g., GPS waypoints or routing commands) embedded into the same space of goal tokens. This flexibility and ability to accommodate a variety of downstream problem domains establishes ViNT as an effective foundation model for mobile robotics. For videos, code, and model checkpoints, see our project page at https://visualnav-transformer.github.io.

  • 7 authors
·
Jun 26, 2023

A Multi-Task Foundation Model for Wireless Channel Representation Using Contrastive and Masked Autoencoder Learning

Current applications of self-supervised learning to wireless channel representation often borrow paradigms developed for text and image processing, without fully addressing the unique characteristics and constraints of wireless communications. To bridge this gap, we introduce ContraWiMAE, Wireless Contrastive Masked Autoencoder, a transformer-based foundation model that unifies masked reconstruction and masked contrastive learning for wireless channel representation. Our key innovation is a new wireless-inspired contrastive objective that exploits the inherent characteristics of wireless environment, including noise, fading, and partial observability, as natural augmentation. Through extensive evaluation on unseen scenarios and conditions, we demonstrate our method's effectiveness in multiple downstream tasks, including cross-frequency beam selection, line-of-sight detection, and channel estimation. ContraWiMAE exhibits superior linear separability and adaptability in diverse wireless environments, demonstrating exceptional data efficiency and competitive performance compared with supervised baselines under challenging conditions. Comparative evaluations against a state-of-the-art wireless channel foundation model confirm the superior performance and data efficiency of our approach, highlighting its potential as a powerful baseline for future research in self-supervised wireless channel representation learning. To foster further work in this direction, we release the model weights and training pipeline for ContraWiMAE.

  • 3 authors
·
May 14, 2025

Spectral-Enhanced Transformers: Leveraging Large-Scale Pretrained Models for Hyperspectral Object Tracking

Hyperspectral object tracking using snapshot mosaic cameras is emerging as it provides enhanced spectral information alongside spatial data, contributing to a more comprehensive understanding of material properties. Using transformers, which have consistently outperformed convolutional neural networks (CNNs) in learning better feature representations, would be expected to be effective for Hyperspectral object tracking. However, training large transformers necessitates extensive datasets and prolonged training periods. This is particularly critical for complex tasks like object tracking, and the scarcity of large datasets in the hyperspectral domain acts as a bottleneck in achieving the full potential of powerful transformer models. This paper proposes an effective methodology that adapts large pretrained transformer-based foundation models for hyperspectral object tracking. We propose an adaptive, learnable spatial-spectral token fusion module that can be extended to any transformer-based backbone for learning inherent spatial-spectral features in hyperspectral data. Furthermore, our model incorporates a cross-modality training pipeline that facilitates effective learning across hyperspectral datasets collected with different sensor modalities. This enables the extraction of complementary knowledge from additional modalities, whether or not they are present during testing. Our proposed model also achieves superior performance with minimal training iterations.

  • 5 authors
·
Feb 25, 2025

HyperSIGMA: Hyperspectral Intelligence Comprehension Foundation Model

Accurate hyperspectral image (HSI) interpretation is critical for providing valuable insights into various earth observation-related applications such as urban planning, precision agriculture, and environmental monitoring. However, existing HSI processing methods are predominantly task-specific and scene-dependent, which severely limits their ability to transfer knowledge across tasks and scenes, thereby reducing the practicality in real-world applications. To address these challenges, we present HyperSIGMA, a vision transformer-based foundation model that unifies HSI interpretation across tasks and scenes, scalable to over one billion parameters. To overcome the spectral and spatial redundancy inherent in HSIs, we introduce a novel sparse sampling attention (SSA) mechanism, which effectively promotes the learning of diverse contextual features and serves as the basic block of HyperSIGMA. HyperSIGMA integrates spatial and spectral features using a specially designed spectral enhancement module. In addition, we construct a large-scale hyperspectral dataset, HyperGlobal-450K, for pre-training, which contains about 450K hyperspectral images, significantly surpassing existing datasets in scale. Extensive experiments on various high-level and low-level HSI tasks demonstrate HyperSIGMA's versatility and superior representational capability compared to current state-of-the-art methods. Moreover, HyperSIGMA shows significant advantages in scalability, robustness, cross-modal transferring capability, real-world applicability, and computational efficiency. The code and models will be released at https://github.com/WHU-Sigma/HyperSIGMA.

  • 22 authors
·
Jun 17, 2024

StainNet: A Special Staining Self-Supervised Vision Transformer for Computational Pathology

Foundation models trained with self-supervised learning (SSL) on large-scale histological images have significantly accelerated the development of computational pathology. These models can serve as backbones for region-of-interest (ROI) image analysis or patch-level feature extractors in whole-slide images (WSIs) based on multiple instance learning (MIL). Existing pathology foundation models (PFMs) are typically pre-trained on Hematoxylin-Eosin (H&E) stained pathology images. However, images with special stains, such as immunohistochemistry, are also frequently used in clinical practice. PFMs pre-trained mainly on H\&E-stained images may be limited in clinical applications involving special stains. To address this issue, we propose StainNet, a specialized foundation model for special stains based on the vision transformer (ViT) architecture. StainNet adopts a self-distillation SSL approach and is trained on over 1.4 million patch images cropping from 20,231 publicly available special staining WSIs in the HISTAI database. To evaluate StainNet, we conduct experiments on an in-house slide-level liver malignancy classification task and two public ROI-level datasets to demonstrate its strong ability. We also perform few-ratio learning and retrieval evaluations, and compare StainNet with recently larger PFMs to further highlight its strengths. We have released the StainNet model weights at: https://huggingface.co/JWonderLand/StainNet.

  • 9 authors
·
Dec 11, 2025

LABOR-LLM: Language-Based Occupational Representations with Large Language Models

Many empirical studies of labor market questions rely on estimating relatively simple predictive models using small, carefully constructed longitudinal survey datasets based on hand-engineered features. Large Language Models (LLMs), trained on massive datasets, encode vast quantities of world knowledge and can be used for the next job prediction problem. However, while an off-the-shelf LLM produces plausible career trajectories when prompted, the probability with which an LLM predicts a particular job transition conditional on career history will not, in general, align with the true conditional probability in a given population. Recently, Vafa et al. (2024) introduced a transformer-based "foundation model", CAREER, trained using a large, unrepresentative resume dataset, that predicts transitions between jobs; it further demonstrated how transfer learning techniques can be used to leverage the foundation model to build better predictive models of both transitions and wages that reflect conditional transition probabilities found in nationally representative survey datasets. This paper considers an alternative where the fine-tuning of the CAREER foundation model is replaced by fine-tuning LLMs. For the task of next job prediction, we demonstrate that models trained with our approach outperform several alternatives in terms of predictive performance on the survey data, including traditional econometric models, CAREER, and LLMs with in-context learning, even though the LLM can in principle predict job titles that are not allowed in the survey data. Further, we show that our fine-tuned LLM-based models' predictions are more representative of the career trajectories of various workforce subpopulations than off-the-shelf LLM models and CAREER. We conduct experiments and analyses that highlight the sources of the gains in the performance of our models for representative predictions.

  • 5 authors
·
Jun 25, 2024

LoRA-Mixer: Coordinate Modular LoRA Experts Through Serial Attention Routing

Recent efforts to combine low-rank adaptation (LoRA) with mixture-of-experts (MoE) for adapting large language models (LLMs) to multiple tasks still exhibit prevailing limitations: they either swap entire attention/feed-forward layers for switch experts or bolt on parallel expert branches, diluting parameter efficiency and task fidelity. We propose the LoRA-Mixer, a modular and lightweight MoE framework that integrates LoRA experts. Our core innovation lies in replacing the projection matrices of the attention module's input/output linear layers with dynamically routed, task-specific LoRA experts. This design ensures seamless compatibility with diverse foundation models, including transformers and state space models (SSMs), by leveraging their inherent linear projection structures. The framework supports two operational paradigms: (1) joint optimization of LoRA experts and routing mechanisms via a novel hard-soft routing strategy, or (2) direct deployment of pre-trained, frozen LoRA modules sourced from external repositories. To enable robust router training with limited data while ensuring stable routing decisions and maximizing expert reuse, we introduce an adaptive Specialization Balance Loss (SBL) that jointly optimizes expert balance and task-specific alignment. Extensive experiments on seven benchmark datasets, including MedQA, CoLA, SST-2, GSM8K, ARC-E, ARC-C, and HumanEval, demonstrate the effectiveness of LoRA-Mixer. On datasets such as GSM8K, HumanEval, and MedQA, LoRA-Mixer achieves significant improvements of 7.61%, 4.88%, and 3.08% over the base models, respectively. Compared with state-of-the-art methods, LoRA-Mixer achieves additional improvements of 1.09%, 1.45%, and 1.68%, respectively, using only 48% of the parameters, demonstrating its efficiency and strong performance.

  • 6 authors
·
Jun 17, 2025

A Survey of GPT-3 Family Large Language Models Including ChatGPT and GPT-4

Large language models (LLMs) are a special class of pretrained language models obtained by scaling model size, pretraining corpus and computation. LLMs, because of their large size and pretraining on large volumes of text data, exhibit special abilities which allow them to achieve remarkable performances without any task-specific training in many of the natural language processing tasks. The era of LLMs started with OpenAI GPT-3 model, and the popularity of LLMs is increasing exponentially after the introduction of models like ChatGPT and GPT4. We refer to GPT-3 and its successor OpenAI models, including ChatGPT and GPT4, as GPT-3 family large language models (GLLMs). With the ever-rising popularity of GLLMs, especially in the research community, there is a strong need for a comprehensive survey which summarizes the recent research progress in multiple dimensions and can guide the research community with insightful future research directions. We start the survey paper with foundation concepts like transformers, transfer learning, self-supervised learning, pretrained language models and large language models. We then present a brief overview of GLLMs and discuss the performances of GLLMs in various downstream tasks, specific domains and multiple languages. We also discuss the data labelling and data augmentation abilities of GLLMs, the robustness of GLLMs, the effectiveness of GLLMs as evaluators, and finally, conclude with multiple insightful future research directions. To summarize, this comprehensive survey paper will serve as a good resource for both academic and industry people to stay updated with the latest research related to GPT-3 family large language models.

  • 1 authors
·
Oct 4, 2023

NovoMolGen: Rethinking Molecular Language Model Pretraining

Designing de-novo molecules with desired property profiles requires efficient exploration of the vast chemical space ranging from 10^{23} to 10^{60} possible synthesizable candidates. While various deep generative models have been developed to design small molecules using diverse input representations, Molecular Large Language Models (Mol-LLMs) based on string representations have emerged as a scalable approach capable of exploring billions of molecules. However, there remains limited understanding regarding how standard language modeling practices such as textual representations, tokenization strategies, model size, and dataset scale impact molecular generation performance. In this work, we systematically investigate these critical aspects by introducing NovoMolGen, a family of transformer-based foundation models pretrained on 1.5 billion molecules for de-novo molecule generation. Through extensive empirical analyses, we identify a weak correlation between performance metrics measured during pretraining and actual downstream performance, revealing important distinctions between molecular and general NLP training dynamics. NovoMolGen establishes new state-of-the-art results, substantially outperforming prior Mol-LLMs and specialized generative models in both unconstrained and goal-directed molecular generation tasks, thus providing a robust foundation for advancing efficient and effective molecular modeling strategies.

  • 5 authors
·
Aug 18, 2025

Zeus: Zero-shot LLM Instruction for Union Segmentation in Multimodal Medical Imaging

Medical image segmentation has achieved remarkable success through the continuous advancement of UNet-based and Transformer-based foundation backbones. However, clinical diagnosis in the real world often requires integrating domain knowledge, especially textual information. Conducting multimodal learning involves visual and text modalities shown as a solution, but collecting paired vision-language datasets is expensive and time-consuming, posing significant challenges. Inspired by the superior ability in numerous cross-modal tasks for Large Language Models (LLMs), we proposed a novel Vision-LLM union framework to address the issues. Specifically, we introduce frozen LLMs for zero-shot instruction generation based on corresponding medical images, imitating the radiology scanning and report generation process. {To better approximate real-world diagnostic processes}, we generate more precise text instruction from multimodal radiology images (e.g., T1-w or T2-w MRI and CT). Based on the impressive ability of semantic understanding and rich knowledge of LLMs. This process emphasizes extracting special features from different modalities and reunion the information for the ultimate clinical diagnostic. With generated text instruction, our proposed union segmentation framework can handle multimodal segmentation without prior collected vision-language datasets. To evaluate our proposed method, we conduct comprehensive experiments with influential baselines, the statistical results and the visualized case study demonstrate the superiority of our novel method.}

  • 5 authors
·
Apr 8, 2025

Entropy-Guided Attention for Private LLMs

The pervasiveness of proprietary language models has raised critical privacy concerns, necessitating advancements in private inference (PI), where computations are performed directly on encrypted data without revealing users' sensitive information. While PI offers a promising solution, its practical deployment is hindered by substantial communication and latency overheads, primarily stemming from nonlinear operations. To address this, we introduce an information-theoretic framework to characterize the role of nonlinearities in decoder-only language models, laying a principled foundation for optimizing transformer-architectures tailored to the demands of PI. By leveraging Shannon's entropy as a quantitative measure, we uncover the previously unexplored dual significance of nonlinearities: beyond ensuring training stability, they are crucial for maintaining attention head diversity. Specifically, we find that their removal triggers two critical failure modes: {\em entropy collapse} in deeper layers that destabilizes training, and {\em entropic overload} in earlier layers that leads to under-utilization of Multi-Head Attention's (MHA) representational capacity. We propose an entropy-guided attention mechanism paired with a novel entropy regularization technique to mitigate entropic overload. Additionally, we explore PI-friendly alternatives to layer normalization for preventing entropy collapse and stabilizing the training of LLMs with reduced-nonlinearities. Our study bridges the gap between information theory and architectural design, establishing entropy dynamics as a principled guide for developing efficient PI architectures. The code and implementation are available at https://github.com/Nandan91/entropy-guided-attention-llm{entropy-guided-llm}.

  • 2 authors
·
Jan 6, 2025 8

Doracamom: Joint 3D Detection and Occupancy Prediction with Multi-view 4D Radars and Cameras for Omnidirectional Perception

3D object detection and occupancy prediction are critical tasks in autonomous driving, attracting significant attention. Despite the potential of recent vision-based methods, they encounter challenges under adverse conditions. Thus, integrating cameras with next-generation 4D imaging radar to achieve unified multi-task perception is highly significant, though research in this domain remains limited. In this paper, we propose Doracamom, the first framework that fuses multi-view cameras and 4D radar for joint 3D object detection and semantic occupancy prediction, enabling comprehensive environmental perception. Specifically, we introduce a novel Coarse Voxel Queries Generator that integrates geometric priors from 4D radar with semantic features from images to initialize voxel queries, establishing a robust foundation for subsequent Transformer-based refinement. To leverage temporal information, we design a Dual-Branch Temporal Encoder that processes multi-modal temporal features in parallel across BEV and voxel spaces, enabling comprehensive spatio-temporal representation learning. Furthermore, we propose a Cross-Modal BEV-Voxel Fusion module that adaptively fuses complementary features through attention mechanisms while employing auxiliary tasks to enhance feature quality. Extensive experiments on the OmniHD-Scenes, View-of-Delft (VoD), and TJ4DRadSet datasets demonstrate that Doracamom achieves state-of-the-art performance in both tasks, establishing new benchmarks for multi-modal 3D perception. Code and models will be publicly available.

  • 11 authors
·
Jan 25, 2025

Urban Spatio-Temporal Foundation Models for Climate-Resilient Housing: Scaling Diffusion Transformers for Disaster Risk Prediction

Climate hazards increasingly disrupt urban transportation and emergency-response operations by damaging housing stock, degrading infrastructure, and reducing network accessibility. This paper presents Skjold-DiT, a diffusion-transformer framework that integrates heterogeneous spatio-temporal urban data to forecast building-level climate-risk indicators while explicitly incorporating transportation-network structure and accessibility signals relevant to intelligent vehicles (e.g., emergency reachability and evacuation-route constraints). Concretely, Skjold-DiT enables hazard-conditioned routing constraints by producing calibrated, uncertainty-aware accessibility layers (reachability, travel-time inflation, and route redundancy) that can be consumed by intelligent-vehicle routing and emergency dispatch systems. Skjold-DiT combines: (1) Fjell-Prompt, a prompt-based conditioning interface designed to support cross-city transfer; (2) Norrland-Fusion, a cross-modal attention mechanism unifying hazard maps/imagery, building attributes, demographics, and transportation infrastructure into a shared latent representation; and (3) Valkyrie-Forecast, a counterfactual simulator for generating probabilistic risk trajectories under intervention prompts. We introduce the Baltic-Caspian Urban Resilience (BCUR) dataset with 847,392 building-level observations across six cities, including multi-hazard annotations (e.g., flood and heat indicators) and transportation accessibility features. Experiments evaluate prediction quality, cross-city generalization, calibration, and downstream transportation-relevant outcomes, including reachability and hazard-conditioned travel times under counterfactual interventions.

  • 3 authors
·
Feb 5 2

Mixture-of-Transformers: A Sparse and Scalable Architecture for Multi-Modal Foundation Models

The development of large language models (LLMs) has expanded to multi-modal systems capable of processing text, images, and speech within a unified framework. Training these models demands significantly larger datasets and computational resources compared to text-only LLMs. To address the scaling challenges, we introduce Mixture-of-Transformers (MoT), a sparse multi-modal transformer architecture that significantly reduces pretraining computational costs. MoT decouples non-embedding parameters of the model by modality -- including feed-forward networks, attention matrices, and layer normalization -- enabling modality-specific processing with global self-attention over the full input sequence. We evaluate MoT across multiple settings and model scales. In the Chameleon 7B setting (autoregressive text-and-image generation), MoT matches the dense baseline's performance using only 55.8\% of the FLOPs. When extended to include speech, MoT reaches speech performance comparable to the dense baseline with only 37.2\% of the FLOPs. In the Transfusion setting, where text and image are trained with different objectives, a 7B MoT model matches the image modality performance of the dense baseline with one third of the FLOPs, and a 760M MoT model outperforms a 1.4B dense baseline across key image generation metrics. System profiling further highlights MoT's practical benefits, achieving dense baseline image quality in 47.2\% of the wall-clock time and text quality in 75.6\% of the wall-clock time (measured on AWS p4de.24xlarge instances with NVIDIA A100 GPUs).

  • 11 authors
·
Nov 7, 2024 2

Z-Image: An Efficient Image Generation Foundation Model with Single-Stream Diffusion Transformer

The landscape of high-performance image generation models is currently dominated by proprietary systems, such as Nano Banana Pro and Seedream 4.0. Leading open-source alternatives, including Qwen-Image, Hunyuan-Image-3.0 and FLUX.2, are characterized by massive parameter counts (20B to 80B), making them impractical for inference, and fine-tuning on consumer-grade hardware. To address this gap, we propose Z-Image, an efficient 6B-parameter foundation generative model built upon a Scalable Single-Stream Diffusion Transformer (S3-DiT) architecture that challenges the "scale-at-all-costs" paradigm. By systematically optimizing the entire model lifecycle -- from a curated data infrastructure to a streamlined training curriculum -- we complete the full training workflow in just 314K H800 GPU hours (approx. $630K). Our few-step distillation scheme with reward post-training further yields Z-Image-Turbo, offering both sub-second inference latency on an enterprise-grade H800 GPU and compatibility with consumer-grade hardware (<16GB VRAM). Additionally, our omni-pre-training paradigm also enables efficient training of Z-Image-Edit, an editing model with impressive instruction-following capabilities. Both qualitative and quantitative experiments demonstrate that our model achieves performance comparable to or surpassing that of leading competitors across various dimensions. Most notably, Z-Image exhibits exceptional capabilities in photorealistic image generation and bilingual text rendering, delivering results that rival top-tier commercial models, thereby demonstrating that state-of-the-art results are achievable with significantly reduced computational overhead. We publicly release our code, weights, and online demo to foster the development of accessible, budget-friendly, yet state-of-the-art generative models.

Tongyi-MAI Tongyi-MAI
·
Nov 27, 2025 7

HiDream-I1: A High-Efficient Image Generative Foundation Model with Sparse Diffusion Transformer

Recent advancements in image generative foundation models have prioritized quality improvements but often at the cost of increased computational complexity and inference latency. To address this critical trade-off, we introduce HiDream-I1, a new open-source image generative foundation model with 17B parameters that achieves state-of-the-art image generation quality within seconds. HiDream-I1 is constructed with a new sparse Diffusion Transformer (DiT) structure. Specifically, it starts with a dual-stream decoupled design of sparse DiT with dynamic Mixture-of-Experts (MoE) architecture, in which two separate encoders are first involved to independently process image and text tokens. Then, a single-stream sparse DiT structure with dynamic MoE architecture is adopted to trigger multi-model interaction for image generation in a cost-efficient manner. To support flexiable accessibility with varied model capabilities, we provide HiDream-I1 in three variants: HiDream-I1-Full, HiDream-I1-Dev, and HiDream-I1-Fast. Furthermore, we go beyond the typical text-to-image generation and remould HiDream-I1 with additional image conditions to perform precise, instruction-based editing on given images, yielding a new instruction-based image editing model namely HiDream-E1. Ultimately, by integrating text-to-image generation and instruction-based image editing, HiDream-I1 evolves to form a comprehensive image agent (HiDream-A1) capable of fully interactive image creation and refinement. To accelerate multi-modal AIGC research, we have open-sourced all the codes and model weights of HiDream-I1-Full, HiDream-I1-Dev, HiDream-I1-Fast, HiDream-E1 through our project websites: https://github.com/HiDream-ai/HiDream-I1 and https://github.com/HiDream-ai/HiDream-E1. All features can be directly experienced via https://vivago.ai/studio.

  • 22 authors
·
May 28, 2025

RePack: Representation Packing of Vision Foundation Model Features Enhances Diffusion Transformer

The superior representation capability of pre-trained vision foundation models (VFMs) has been harnessed for enhancing latent diffusion models (LDMs). These approaches inject the rich semantics from high-dimensional VFM representations (e.g., DINOv3) into LDMs at different phases, resulting in accelerated learning and better generation performance. However, the high-dimensionality of VFM representations may also lead to Information Overload, particularly when the VFM features exceed the size of the original image for decoding. To address this issue while preserving the utility of VFM features, we propose RePack (Representation Packing), a simple yet effective framework for improving Diffusion Transformers (DiTs). RePack transforms the VFM representation into a more compact, decoder-friendly representation by projecting onto low-dimensional manifolds. We find that RePack can effectively filter out non-semantic noise while preserving the core structural information needed for high-fidelity reconstruction. Experimental results show that RePack significantly accelerates DiT convergence and outperforms recent methods that directly inject raw VFM features into the decoder for image reconstruction. On DiT-XL/2, RePack achieves an FID of 3.66 in only 64 epochs, which is 35% faster than the state-of-the-art method. This demonstrates that RePack successfully extracts the core semantics of VFM representations while bypassing their high-dimensionality side effects.

  • 4 authors
·
Dec 12, 2025

HiDream-O1-Image: A Natively Unified Image Generative Foundation Model with Pixel-level Unified Transformer

The evolution of visual generative models has long been constrained by fragmented architectures relying on disjoint text encoders and external VAEs. In this report, we present HiDream-O1-Image, a natively unified generative foundation model via pixel-space Diffusion Transformer, that pioneers a paradigm shift from modular architectures to an end-to-end in-context visual generation engine. By mapping raw image pixels, text tokens, and task-specific conditions into a single shared token space, HiDream-O1-Image achieves a structural unification of multimodal inputs within an Unified Transformer (UiT) architecture. This native encoding paradigm eliminates the need for separate VAEs or disjoint pre-trained text encoders, allowing the model to treat diverse generation and editing tasks as a consistent in-context reasoning process. Extensive experiments show that HiDream-O1-Image excels across various generation tasks, including text-to-image generation, instruction-based editing, and subject-driven personalization. Notably, with only 8B parameters, HiDream-O1-Image (8B) achieves performance parity with or even surpasses established state-of-the-art models with significantly larger parameters (e.g., 27B Qwen-Image). Crucially, to validate the immense scalability of this paradigm, we successfully scale the architecture up to over 200B parameters. Experimental results demonstrate that this massive-scale version HiDream-O1-Image-Pro (200B+) unlocks unprecedented generative capabilities and superior performance, establishing new state-of-the-art benchmarks. Ultimately, HiDream-O1-Image highlights the immense potential of natively unified architectures and charts a highly scalable path toward next-generation multimodal AI.

  • 25 authors
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May 10

BehaveGPT: A Foundation Model for Large-scale User Behavior Modeling

In recent years, foundational models have revolutionized the fields of language and vision, demonstrating remarkable abilities in understanding and generating complex data; however, similar advances in user behavior modeling have been limited, largely due to the complexity of behavioral data and the challenges involved in capturing intricate temporal and contextual relationships in user activities. To address this, we propose BehaveGPT, a foundational model designed specifically for large-scale user behavior prediction. Leveraging transformer-based architecture and a novel pretraining paradigm, BehaveGPT is trained on vast user behavior datasets, allowing it to learn complex behavior patterns and support a range of downstream tasks, including next behavior prediction, long-term generation, and cross-domain adaptation. Our approach introduces the DRO-based pretraining paradigm tailored for user behavior data, which improves model generalization and transferability by equitably modeling both head and tail behaviors. Extensive experiments on real-world datasets demonstrate that BehaveGPT outperforms state-of-the-art baselines, achieving more than a 10% improvement in macro and weighted recall, showcasing its ability to effectively capture and predict user behavior. Furthermore, we measure the scaling law in the user behavior domain for the first time on the Honor dataset, providing insights into how model performance scales with increased data and parameter sizes.

  • 8 authors
·
May 23, 2025

TEDDY: A Family Of Foundation Models For Understanding Single Cell Biology

Understanding the biological mechanism of disease is critical for medicine, and in particular drug discovery. AI-powered analysis of genome-scale biological data hold great potential in this regard. The increasing availability of single-cell RNA sequencing data has enabled the development of large foundation models for disease biology. However, existing foundation models either do not improve or only modestly improve over task-specific models in downstream applications. Here, we explored two avenues for improving the state-of-the-art. First, we scaled the pre-training dataset to 116 million cells, which is larger than those used by previous models. Second, we leveraged the availability of large-scale biological annotations as a form of supervision during pre-training. We trained the TEDDY family of models comprising six transformer-based state-of-the-art single-cell foundation models with 70 million, 160 million, and 400 million parameters. We vetted our models on two downstream evaluation tasks -- identifying the underlying disease state of held-out donors not seen during training and distinguishing healthy cells from diseased ones for disease conditions and donors not seen during training. Scaling experiments showed that performance improved predictably with both data volume and parameter count. Our models showed substantial improvement over existing work on the first task and more muted improvements on the second.

  • 16 authors
·
Mar 5, 2025

Foundation Model of Electronic Medical Records for Adaptive Risk Estimation

Hospitals struggle to predict critical outcomes. Traditional early warning systems, like NEWS and MEWS, rely on static variables and fixed thresholds, limiting their adaptability, accuracy, and personalization. We previously developed the Enhanced Transformer for Health Outcome Simulation (ETHOS), an AI model that tokenizes patient health timelines (PHTs) from EHRs and uses transformer-based architectures to predict future PHTs. ETHOS is a versatile framework for developing a wide range of applications. In this work, we develop the Adaptive Risk Estimation System (ARES) that leverages ETHOS to compute dynamic, personalized risk probabilities for clinician-defined critical events. ARES also features a personalized explainability module that highlights key clinical factors influencing risk estimates. We evaluated ARES using the MIMIC-IV v2.2 dataset together with its Emergency Department (ED) extension and benchmarked performance against both classical early warning systems and contemporary machine learning models. The entire dataset was tokenized resulting in 285,622 PHTs, comprising over 360 million tokens. ETHOS outperformed benchmark models in predicting hospital admissions, ICU admissions, and prolonged stays, achieving superior AUC scores. Its risk estimates were robust across demographic subgroups, with calibration curves confirming model reliability. The explainability module provided valuable insights into patient-specific risk factors. ARES, powered by ETHOS, advances predictive healthcare AI by delivering dynamic, real-time, personalized risk estimation with patient-specific explainability. Although our results are promising, the clinical impact remains uncertain. Demonstrating ARES's true utility in real-world settings will be the focus of our future work. We release the source code to facilitate future research.

  • 12 authors
·
Feb 9, 2025

Analyzing Transformer Dynamics as Movement through Embedding Space

Transformer based language models exhibit intelligent behaviors such as understanding natural language, recognizing patterns, acquiring knowledge, reasoning, planning, reflecting and using tools. This paper explores how their underlying mechanics give rise to intelligent behaviors. Towards that end, we propose framing Transformer dynamics as movement through embedding space. Examining Transformers through this perspective reveals key insights, establishing a Theory of Transformers: 1) Intelligent behaviours map to paths in Embedding Space which, the Transformer random-walks through during inferencing. 2) LM training learns a probability distribution over all possible paths. `Intelligence' is learnt by assigning higher probabilities to paths representing intelligent behaviors. No learning can take place in-context; context only narrows the subset of paths sampled during decoding. 5) The Transformer is a self-mapping composition function, folding a context sequence into a context-vector such that it's proximity to a token-vector reflects its co-occurrence and conditioned probability. Thus, the physical arrangement of vectors in Embedding Space determines path probabilities. 6) Context vectors are composed by aggregating features of the sequence's tokens via a process we call the encoding walk. Attention contributes a - potentially redundant - association-bias to this process. 7) This process is comprised of two principal operation types: filtering (data independent) and aggregation (data dependent). This generalization unifies Transformers with other sequence models. Building upon this foundation, we formalize a popular semantic interpretation of embeddings into a ``concept-space theory'' and find some evidence of it's validity.

  • 1 authors
·
Aug 21, 2023

Foundation Models for Generalist Geospatial Artificial Intelligence

Significant progress in the development of highly adaptable and reusable Artificial Intelligence (AI) models is expected to have a significant impact on Earth science and remote sensing. Foundation models are pre-trained on large unlabeled datasets through self-supervision, and then fine-tuned for various downstream tasks with small labeled datasets. This paper introduces a first-of-a-kind framework for the efficient pre-training and fine-tuning of foundational models on extensive geospatial data. We have utilized this framework to create Prithvi, a transformer-based geospatial foundational model pre-trained on more than 1TB of multispectral satellite imagery from the Harmonized Landsat-Sentinel 2 (HLS) dataset. Our study demonstrates the efficacy of our framework in successfully fine-tuning Prithvi to a range of Earth observation tasks that have not been tackled by previous work on foundation models involving multi-temporal cloud gap imputation, flood mapping, wildfire scar segmentation, and multi-temporal crop segmentation. Our experiments show that the pre-trained model accelerates the fine-tuning process compared to leveraging randomly initialized weights. In addition, pre-trained Prithvi compares well against the state-of-the-art, e.g., outperforming a conditional GAN model in multi-temporal cloud imputation by up to 5pp (or 5.7%) in the structural similarity index. Finally, due to the limited availability of labeled data in the field of Earth observation, we gradually reduce the quantity of available labeled data for refining the model to evaluate data efficiency and demonstrate that data can be decreased significantly without affecting the model's accuracy. The pre-trained 100 million parameter model and corresponding fine-tuning workflows have been released publicly as open source contributions to the global Earth sciences community through Hugging Face.

  • 33 authors
·
Oct 28, 2023 1

BioMedGPT: Open Multimodal Generative Pre-trained Transformer for BioMedicine

Foundation models (FMs) have exhibited remarkable performance across a wide range of downstream tasks in many domains. Nevertheless, general-purpose FMs often face challenges when confronted with domain-specific problems, due to their limited access to the proprietary training data in a particular domain. In biomedicine, there are various biological modalities, such as molecules, proteins, and cells, which are encoded by the language of life and exhibit significant modality gaps with human natural language. In this paper, we introduce BioMedGPT, an open multimodal generative pre-trained transformer (GPT) for biomedicine, to bridge the gap between the language of life and human natural language. BioMedGPT allows users to easily ``communicate'' with diverse biological modalities through free text, which is the first of its kind. BioMedGPT aligns different biological modalities with natural language via a large generative language model, namely, BioMedGPT-LM. We publish BioMedGPT-10B, which unifies the feature spaces of molecules, proteins, and natural language via encoding and alignment. Through fine-tuning, BioMedGPT-10B outperforms or is on par with human and significantly larger general-purpose foundation models on the biomedical QA task. It also demonstrates promising performance in the molecule QA and protein QA tasks, which could greatly accelerate the discovery of new drugs and therapeutic targets. In addition, BioMedGPT-LM-7B is the first large generative language model based on Llama2 in the biomedical domain, therefore is commercial friendly. Both BioMedGPT-10B and BioMedGPT-LM-7B are open-sourced to the research community. In addition, we publish the datasets that are meticulously curated for the alignment of multi-modalities, i.e., PubChemQA and UniProtQA. All the models, codes, and datasets are available at https://github.com/PharMolix/OpenBioMed.

  • 7 authors
·
Aug 18, 2023

FastVGGT: Training-Free Acceleration of Visual Geometry Transformer

Foundation models for 3D vision have recently demonstrated remarkable capabilities in 3D perception. However, scaling these models to long-sequence image inputs remains a significant challenge due to inference-time inefficiency. In this work, we present a detailed analysis of VGGT, a state-of-the-art feed-forward visual geometry model and identify its primary bottleneck. Visualization further reveals a token collapse phenomenon in the attention maps. Motivated by these findings, we explore the potential of token merging in the feed-forward visual geometry model. Owing to the unique architectural and task-specific properties of 3D models, directly applying existing merging techniques proves challenging. To this end, we propose FastVGGT, which, for the first time, leverages token merging in the 3D domain through a training-free mechanism for accelerating VGGT. we devise a unique token partitioning strategy tailored to 3D architectures and tasks, effectively eliminating redundant computation while preserving VGGT's powerful reconstruction capacity. Extensive experiments on multiple 3D geometry benchmarks validate the effectiveness of our approach. Notably, with 1000 input images, FastVGGT achieves a 4x speedup over VGGT while mitigating error accumulation in long-sequence scenarios. These findings underscore the potential of token merging as a principled solution for scalable 3D vision systems. Code is available at: https://mystorm16.github.io/fastvggt/.

  • 4 authors
·
Sep 2, 2025

LUNA: Efficient and Topology-Agnostic Foundation Model for EEG Signal Analysis

Electroencephalography (EEG) offers a non-invasive lens into human brain activity, but building large-scale models is hampered by topological heterogeneity: each public EEG data defines its own electrode layout, limiting generalization. We introduce LUNA (Latent Unified Network Architecture), a self-supervised foundation model that reconciles disparate electrode geometries while scaling linearly -- not quadratically -- with channel count. LUNA compresses multi-channel EEG into a fixed-size, topology-agnostic latent space via learned queries and cross-attention. Downstream transformer blocks then operate exclusively on this latent representation using patch-wise temporal self-attention, decoupling computation from electrode count. Pre-trained on TUEG and Siena (over 21,000 hours of raw EEG across diverse montages) using a masked-patch reconstruction objective, LUNA transfers effectively to four downstream tasks: abnormality detection, artifact rejection, slowing classification, and emotion recognition. It demonstrates highly competitive performance across several benchmarks, achieving state-of-the-art results on TUAR and TUSL, e.g., 0.921 AUROC on TUAR, while reducing FLOPs by 300x and trimming GPU memory use by up to 10x. Critically, these gains are consistent across all evaluated electrode configurations. Code is available at https://github.com/pulp-bio/BioFoundation

PulpBio Pulp Platform Bio
·
Oct 25, 2025

RDT-1B: a Diffusion Foundation Model for Bimanual Manipulation

Bimanual manipulation is essential in robotics, yet developing foundation models is extremely challenging due to the inherent complexity of coordinating two robot arms (leading to multi-modal action distributions) and the scarcity of training data. In this paper, we present the Robotics Diffusion Transformer (RDT), a pioneering diffusion foundation model for bimanual manipulation. RDT builds on diffusion models to effectively represent multi-modality, with innovative designs of a scalable Transformer to deal with the heterogeneity of multi-modal inputs and to capture the nonlinearity and high frequency of robotic data. To address data scarcity, we further introduce a Physically Interpretable Unified Action Space, which can unify the action representations of various robots while preserving the physical meanings of original actions, facilitating learning transferrable physical knowledge. With these designs, we managed to pre-train RDT on the largest collection of multi-robot datasets to date and scaled it up to 1.2B parameters, which is the largest diffusion-based foundation model for robotic manipulation. We finally fine-tuned RDT on a self-created multi-task bimanual dataset with over 6K+ episodes to refine its manipulation capabilities. Experiments on real robots demonstrate that RDT significantly outperforms existing methods. It exhibits zero-shot generalization to unseen objects and scenes, understands and follows language instructions, learns new skills with just 1~5 demonstrations, and effectively handles complex, dexterous tasks. We refer to https://rdt-robotics.github.io/rdt-robotics/ for the code and videos.

  • 9 authors
·
Oct 10, 2024

Imaging foundation model for universal enhancement of non-ideal measurement CT

Non-ideal measurement computed tomography (NICT), which sacrifices optimal imaging standards for new advantages in CT imaging, is expanding the clinical application scope of CT images. However, with the reduction of imaging standards, the image quality has also been reduced, extremely limiting the clinical acceptability. Although numerous studies have demonstrated the feasibility of deep learning for the NICT enhancement in specific scenarios, their high data cost and limited generalizability have become large obstacles. The recent research on the foundation model has brought new opportunities for building a universal NICT enhancement model - bridging the image quality degradation with minimal data cost. However, owing to the challenges in the collection of large pre-training datasets and the compatibility of data variation, no success has been reported. In this paper, we propose a multi-scale integrated Transformer AMPlifier (TAMP), the first imaging foundation model for universal NICT enhancement. It has been pre-trained on a large-scale physical-driven simulation dataset with 3.6 million NICT-ICT image pairs, and is able to directly generalize to the NICT enhancement tasks with various non-ideal settings and body regions. Via the adaptation with few data, it can further achieve professional performance in real-world specific scenarios. Our extensive experiments have demonstrated that the proposed TAMP has significant potential for promoting the exploration and application of NICT and serving a wider range of medical scenarios.

  • 7 authors
·
Oct 2, 2024

Volume Transformer: Revisiting Vanilla Transformers for 3D Scene Understanding

Transformers have become a common foundation across deep learning, yet 3D scene understanding still relies on specialized backbones with strong domain priors. This keeps the field isolated from the broader Transformer ecosystem, limiting the transfer of new advances as well as the benefits of increasingly optimized software and hardware stacks. To bridge this gap, we adapt the vanilla Transformer encoder to 3D scenes with minimal modifications. Given an input 3D scene, we partition it into volumetric patch tokens, process them with full global self-attention, and inject positional information via a 3D extension of rotary positional embeddings. We call the resulting model the Volume Transformer (Volt) and apply it to 3D semantic segmentation. Naively training Volt on standard 3D benchmarks leads to shortcut learning, highlighting the limited scale of current 3D supervision. To overcome this, we introduce a data-efficient training recipe based on strong 3D augmentations, regularization, and distillation from a convolutional teacher, making Volt competitive with state-of-the-art methods. We then scale supervision through joint training on multiple datasets and show that Volt benefits more from increased scale than domain-specific 3D backbones, achieving state-of-the-art results across indoor and outdoor datasets. Finally, when used as a drop-in backbone in a standard 3D instance segmentation pipeline, Volt again sets a new state of the art, highlighting its potential as a simple, scalable, general-purpose backbone for 3D scene understanding.

  • 5 authors
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Apr 20

AgriFM: A Multi-source Temporal Remote Sensing Foundation Model for Crop Mapping

Accurate crop mapping fundamentally relies on modeling multi-scale spatiotemporal patterns, where spatial scales range from individual field textures to landscape-level context, and temporal scales capture both short-term phenological transitions and full growing-season dynamics. Transformer-based remote sensing foundation models (RSFMs) offer promising potential for crop mapping due to their innate ability for unified spatiotemporal processing. However, current RSFMs remain suboptimal for crop mapping: they either employ fixed spatiotemporal windows that ignore the multi-scale nature of crop systems or completely disregard temporal information by focusing solely on spatial patterns. To bridge these gaps, we present AgriFM, a multi-source remote sensing foundation model specifically designed for agricultural crop mapping. Our approach begins by establishing the necessity of simultaneous hierarchical spatiotemporal feature extraction, leading to the development of a modified Video Swin Transformer architecture where temporal down-sampling is synchronized with spatial scaling operations. This modified backbone enables efficient unified processing of long time-series satellite inputs. AgriFM leverages temporally rich data streams from three satellite sources including MODIS, Landsat-8/9 and Sentinel-2, and is pre-trained on a global representative dataset comprising over 25 million image samples supervised by land cover products. The resulting framework incorporates a versatile decoder architecture that dynamically fuses these learned spatiotemporal representations, supporting diverse downstream tasks. Comprehensive evaluations demonstrate AgriFM's superior performance over conventional deep learning approaches and state-of-the-art general-purpose RSFMs across all downstream tasks. Codes will be available at https://github.com/flyakon/AgriFM.

  • 10 authors
·
May 27, 2025

X-Fi: A Modality-Invariant Foundation Model for Multimodal Human Sensing

Human sensing, which employs various sensors and advanced deep learning technologies to accurately capture and interpret human body information, has significantly impacted fields like public security and robotics. However, current human sensing primarily depends on modalities such as cameras and LiDAR, each of which has its own strengths and limitations. Furthermore, existing multi-modal fusion solutions are typically designed for fixed modality combinations, requiring extensive retraining when modalities are added or removed for diverse scenarios. In this paper, we propose a modality-invariant foundation model for all modalities, X-Fi, to address this issue. X-Fi enables the independent or combinatory use of sensor modalities without additional training by utilizing a transformer structure to accommodate variable input sizes and incorporating a novel "X-fusion" mechanism to preserve modality-specific features during multimodal integration. This approach not only enhances adaptability but also facilitates the learning of complementary features across modalities. Extensive experiments conducted on the MM-Fi and XRF55 datasets, employing six distinct modalities, demonstrate that X-Fi achieves state-of-the-art performance in human pose estimation (HPE) and human activity recognition (HAR) tasks. The findings indicate that our proposed model can efficiently support a wide range of human sensing applications, ultimately contributing to the evolution of scalable, multimodal sensing technologies.

  • 2 authors
·
Feb 16, 2025

SpecDETR: A Transformer-based Hyperspectral Point Object Detection Network

Hyperspectral target detection (HTD) aims to identify specific materials based on spectral information in hyperspectral imagery and can detect extremely small objects, some of which occupy a smaller than one-pixel area. However, existing HTD methods are developed based on per-pixel binary classification, which limits the feature representation capability for instance-level objects. In this paper, we rethink the hyperspectral target detection from the point object detection perspective, and propose the first specialized network for hyperspectral multi-class point object detection, SpecDETR. Without the visual foundation model of the current object detection framework, SpecDETR treats each pixel in input images as a token and uses a multi-layer Transformer encoder with self-excited subpixel-scale attention modules to directly extract joint spatial-spectral features from images. During feature extraction, we introduce a self-excited mechanism to enhance object features through self-excited amplification, thereby accelerating network convergence. Additionally, SpecDETR regards point object detection as a one-to-many set prediction problem, thereby achieving a concise and efficient DETR decoder that surpasses the state-of-the-art (SOTA) DETR decoder. We develop a simulated hyperSpectral Point Object Detection benchmark termed SPOD, and for the first time, evaluate and compare the performance of current object detection networks and HTD methods on hyperspectral point object detection. Extensive experiments demonstrate that our proposed SpecDETR outperforms SOTA object detection networks and HTD methods. Our code and dataset are available at https://github.com/ZhaoxuLi123/SpecDETR.

  • 6 authors
·
May 16, 2024

GP-MoLFormer: A Foundation Model For Molecular Generation

Transformer-based models trained on large and general purpose datasets consisting of molecular strings have recently emerged as a powerful tool for successfully modeling various structure-property relations. Inspired by this success, we extend the paradigm of training chemical language transformers on large-scale chemical datasets to generative tasks in this work. Specifically, we propose GP-MoLFormer, an autoregressive molecular string generator that is trained on more than 1.1B (billion) chemical SMILES. GP-MoLFormer uses a 46.8M parameter transformer decoder model with linear attention and rotary positional encodings as the base architecture. GP-MoLFormer's utility is evaluated and compared with that of existing baselines on three different tasks: de novo generation, scaffold-constrained molecular decoration, and unconstrained property-guided optimization. While the first two are handled with no additional training, we propose a parameter-efficient fine-tuning method for the last task, which uses property-ordered molecular pairs as input. We call this new approach pair-tuning. Our results show GP-MoLFormer performs better or comparable with baselines across all three tasks, demonstrating its general utility for a variety of molecular generation tasks. We further report strong memorization of training data in GP-MoLFormer generations, which has so far remained unexplored for chemical language models. Our analyses reveal that training data memorization and novelty in generations are impacted by the quality and scale of the training data; duplication bias in training data can enhance memorization at the cost of lowering novelty. We further establish a scaling law relating inference compute and novelty in generations.

  • 7 authors
·
Apr 4, 2024

Scaling Diffusion Transformers Efficiently via $μ$P

Diffusion Transformers have emerged as the foundation for vision generative models, but their scalability is limited by the high cost of hyperparameter (HP) tuning at large scales. Recently, Maximal Update Parametrization (muP) was proposed for vanilla Transformers, which enables stable HP transfer from small to large language models, and dramatically reduces tuning costs. However, it remains unclear whether muP of vanilla Transformers extends to diffusion Transformers, which differ architecturally and objectively. In this work, we generalize standard muP to diffusion Transformers and validate its effectiveness through large-scale experiments. First, we rigorously prove that muP of mainstream diffusion Transformers, including DiT, U-ViT, PixArt-alpha, and MMDiT, aligns with that of the vanilla Transformer, enabling the direct application of existing muP methodologies. Leveraging this result, we systematically demonstrate that DiT-muP enjoys robust HP transferability. Notably, DiT-XL-2-muP with transferred learning rate achieves 2.9 times faster convergence than the original DiT-XL-2. Finally, we validate the effectiveness of muP on text-to-image generation by scaling PixArt-alpha from 0.04B to 0.61B and MMDiT from 0.18B to 18B. In both cases, models under muP outperform their respective baselines while requiring small tuning cost, only 5.5% of one training run for PixArt-alpha and 3% of consumption by human experts for MMDiT-18B. These results establish muP as a principled and efficient framework for scaling diffusion Transformers.

  • 8 authors
·
May 21, 2025 2

Voila: Voice-Language Foundation Models for Real-Time Autonomous Interaction and Voice Role-Play

A voice AI agent that blends seamlessly into daily life would interact with humans in an autonomous, real-time, and emotionally expressive manner. Rather than merely reacting to commands, it would continuously listen, reason, and respond proactively, fostering fluid, dynamic, and emotionally resonant interactions. We introduce Voila, a family of large voice-language foundation models that make a step towards this vision. Voila moves beyond traditional pipeline systems by adopting a new end-to-end architecture that enables full-duplex, low-latency conversations while preserving rich vocal nuances such as tone, rhythm, and emotion. It achieves a response latency of just 195 milliseconds, surpassing the average human response time. Its hierarchical multi-scale Transformer integrates the reasoning capabilities of large language models (LLMs) with powerful acoustic modeling, enabling natural, persona-aware voice generation -- where users can simply write text instructions to define the speaker's identity, tone, and other characteristics. Moreover, Voila supports over one million pre-built voices and efficient customization of new ones from brief audio samples as short as 10 seconds. Beyond spoken dialogue, Voila is designed as a unified model for a wide range of voice-based applications, including automatic speech recognition (ASR), Text-to-Speech (TTS), and, with minimal adaptation, multilingual speech translation. Voila is fully open-sourced to support open research and accelerate progress toward next-generation human-machine interactions.

  • 7 authors
·
May 5, 2025 4

TokenFormer: Rethinking Transformer Scaling with Tokenized Model Parameters

Transformers have become the predominant architecture in foundation models due to their excellent performance across various domains. However, the substantial cost of scaling these models remains a significant concern. This problem arises primarily from their dependence on a fixed number of parameters within linear projections. When architectural modifications (e.g., channel dimensions) are introduced, the entire model typically requires retraining from scratch. As model sizes continue growing, this strategy results in increasingly high computational costs and becomes unsustainable. To overcome this problem, we introduce TokenFormer, a natively scalable architecture that leverages the attention mechanism not only for computations among input tokens but also for interactions between tokens and model parameters, thereby enhancing architectural flexibility. By treating model parameters as tokens, we replace all the linear projections in Transformers with our token-parameter attention layer, where input tokens act as queries and model parameters as keys and values. This reformulation allows for progressive and efficient scaling without necessitating retraining from scratch. Our model scales from 124M to 1.4B parameters by incrementally adding new key-value parameter pairs, achieving performance comparable to Transformers trained from scratch while greatly reducing training costs. Code and models are available at https://github.com/Haiyang-W/TokenFormer.

  • 8 authors
·
Oct 30, 2024 5

METAGENE-1: Metagenomic Foundation Model for Pandemic Monitoring

We pretrain METAGENE-1, a 7-billion-parameter autoregressive transformer model, which we refer to as a metagenomic foundation model, on a novel corpus of diverse metagenomic DNA and RNA sequences comprising over 1.5 trillion base pairs. This dataset is sourced from a large collection of human wastewater samples, processed and sequenced using deep metagenomic (next-generation) sequencing methods. Unlike genomic models that focus on individual genomes or curated sets of specific species, the aim of METAGENE-1 is to capture the full distribution of genomic information present within this wastewater, to aid in tasks relevant to pandemic monitoring and pathogen detection. We carry out byte-pair encoding (BPE) tokenization on our dataset, tailored for metagenomic sequences, and then pretrain our model. In this paper, we first detail the pretraining dataset, tokenization strategy, and model architecture, highlighting the considerations and design choices that enable the effective modeling of metagenomic data. We then show results of pretraining this model on our metagenomic dataset, providing details about our losses, system metrics, and training stability over the course of pretraining. Finally, we demonstrate the performance of METAGENE-1, which achieves state-of-the-art results on a set of genomic benchmarks and new evaluations focused on human-pathogen detection and genomic sequence embedding, showcasing its potential for public health applications in pandemic monitoring, biosurveillance, and early detection of emerging health threats.

  • 7 authors
·
Jan 3, 2025 2

Towards a Physics Foundation Model

Foundation models have revolutionized natural language processing through a ``train once, deploy anywhere'' paradigm, where a single pre-trained model adapts to countless downstream tasks without retraining. Access to a Physics Foundation Model (PFM) would be transformative -- democratizing access to high-fidelity simulations, accelerating scientific discovery, and eliminating the need for specialized solver development. Yet current physics-aware machine learning approaches remain fundamentally limited to single, narrow domains and require retraining for each new system. We present the General Physics Transformer (GPhyT), trained on 1.8 TB of diverse simulation data, that demonstrates foundation model capabilities are achievable for physics. Our key insight is that transformers can learn to infer governing dynamics from context, enabling a single model to simulate fluid-solid interactions, shock waves, thermal convection, and multi-phase dynamics without being told the underlying equations. GPhyT achieves three critical breakthroughs: (1) superior performance across multiple physics domains, outperforming specialized architectures by up to 29x, (2) zero-shot generalization to entirely unseen physical systems through in-context learning, and (3) stable long-term predictions through 50-timestep rollouts. By establishing that a single model can learn generalizable physical principles from data alone, this work opens the path toward a universal PFM that could transform computational science and engineering.

  • 3 authors
·
Sep 17, 2025 2

TabDPT: Scaling Tabular Foundation Models

The challenges faced by neural networks on tabular data are well-documented and have hampered the progress of tabular foundation models. Techniques leveraging in-context learning (ICL) have shown promise here, allowing for dynamic adaptation to unseen data. ICL can provide predictions for entirely new datasets without further training or hyperparameter tuning, therefore providing very fast inference when encountering a novel task. However, scaling ICL for tabular data remains an issue: approaches based on large language models cannot efficiently process numeric tables, and tabular-specific techniques have not been able to effectively harness the power of real data to improve performance and generalization. We are able to overcome these challenges by training tabular-specific ICL-based architectures on real data with self-supervised learning and retrieval, combining the best of both worlds. Our resulting model -- the Tabular Discriminative Pre-trained Transformer (TabDPT) -- achieves state-of-the-art performance on the CC18 (classification) and CTR23 (regression) benchmarks with no task-specific fine-tuning, demonstrating the adapatability and speed of ICL once the model is pre-trained. TabDPT also demonstrates strong scaling as both model size and amount of available data increase, pointing towards future improvements simply through the curation of larger tabular pre-training datasets and training larger models.

Layer6 Layer 6 AI
·
Oct 23, 2024 1

FEMBA: Efficient and Scalable EEG Analysis with a Bidirectional Mamba Foundation Model

Accurate and efficient electroencephalography (EEG) analysis is essential for detecting seizures and artifacts in long-term monitoring, with applications spanning hospital diagnostics to wearable health devices. Robust EEG analytics have the potential to greatly improve patient care. However, traditional deep learning models, especially Transformer-based architectures, are hindered by their quadratic time and memory complexity, making them less suitable for resource-constrained environments. To address these challenges, we present FEMBA (Foundational EEG Mamba + Bidirectional Architecture), a novel self-supervised framework that establishes new efficiency benchmarks for EEG analysis through bidirectional state-space modeling. Unlike Transformer-based models, which incur quadratic time and memory complexity, FEMBA scales linearly with sequence length, enabling more scalable and efficient processing of extended EEG recordings. Trained on over 21,000 hours of unlabeled EEG and fine-tuned on three downstream tasks, FEMBA achieves competitive performance in comparison with transformer models, with significantly lower computational cost. Specifically, it reaches 81.82% balanced accuracy (0.8921 AUROC) on TUAB and 0.949 AUROC on TUAR, while a tiny 7.8M-parameter variant demonstrates viability for resource-constrained devices. These results pave the way for scalable, general-purpose EEG analytics in both clinical and highlight FEMBA as a promising candidate for wearable applications.

PulpBio Pulp Platform Bio
·
Feb 10, 2025

Feature Re-Embedding: Towards Foundation Model-Level Performance in Computational Pathology

Multiple instance learning (MIL) is the most widely used framework in computational pathology, encompassing sub-typing, diagnosis, prognosis, and more. However, the existing MIL paradigm typically requires an offline instance feature extractor, such as a pre-trained ResNet or a foundation model. This approach lacks the capability for feature fine-tuning within the specific downstream tasks, limiting its adaptability and performance. To address this issue, we propose a Re-embedded Regional Transformer (R^2T) for re-embedding the instance features online, which captures fine-grained local features and establishes connections across different regions. Unlike existing works that focus on pre-training powerful feature extractor or designing sophisticated instance aggregator, R^2T is tailored to re-embed instance features online. It serves as a portable module that can seamlessly integrate into mainstream MIL models. Extensive experimental results on common computational pathology tasks validate that: 1) feature re-embedding improves the performance of MIL models based on ResNet-50 features to the level of foundation model features, and further enhances the performance of foundation model features; 2) the R^2T can introduce more significant performance improvements to various MIL models; 3) R^2T-MIL, as an R^2T-enhanced AB-MIL, outperforms other latest methods by a large margin.The code is available at: https://github.com/DearCaat/RRT-MIL.

  • 6 authors
·
Feb 27, 2024

Transformer-Based Hematological Malignancy Prediction from Peripheral Blood Smears in a Real-World Cohort

Peripheral blood smears remain a cornerstone in the diagnosis of hematological neoplasms, offering rapid and valuable insights that inform subsequent diagnostic steps. However, since neoplastic transformations typically arise in the bone marrow, they may not manifest as detectable aberrations in peripheral blood, presenting a diagnostic challenge. In this paper, we introduce cAItomorph, an explainable transformer-based AI model, trained to classify hematological malignancies based on peripheral blood cytomorphology. Our data comprises peripheral blood single-cell images from 6115 patients with diagnoses confirmed by cytomorphology, cytogenetics, molecular genetics, and immunophenotyping from bone marrow samples, and 495 healthy controls, eight coarse classes. cAItomorph leverages the DinoBloom hematology foundation model and aggregates image encodings via a transformer-based architecture into a single vector. It achieves an overall accuracy of 0.72 in eight disease classification, with F1 scores of 0.76 for acute leukemia, 0.80 for myeloproliferative neoplasms and 0.94 for healthy cases. The overall accuracy increases to 0.87 in top-2 predictions. cAItomorph achieves high sensitivity for acute leukemia cases in external test sets. By analyzing attention heads, we demonstrate clinically relevant cell-level attentions in both internal and external test sets. Moreover, our model's calibrated prediction probabilities reduce the false discovery rate from 13.5% to 8.7% without missing any acute leukemia cases, thereby decreasing the number of unnecessary bone marrow aspirations based on peripheral blood smears. This study highlights the potential of AI-assisted diagnostics in hematological malignancies, illustrating how models trained on real-world data could enhance diagnostic accuracy and reduce invasive procedures.

  • 9 authors
·
Sep 23, 2025

BioAnalyst: A Foundation Model for Biodiversity

The accelerating loss of biodiversity presents critical challenges for ecological research and conservation strategies. The preservation of biodiversity is paramount for maintaining ecological balance and ensuring the sustainability of ecosystems. However, biodiversity faces numerous threats, including habitat loss, climate change, and the proliferation of invasive species. Addressing these and other ecology-related challenges, both at local and global scales, requires comprehensive monitoring, predictive and conservation planning capabilities. Artificial Intelligence (AI) Foundation Models (FMs) have gained significant momentum in numerous scientific domains by leveraging vast datasets to learn general-purpose representations adaptable to various downstream tasks. This paradigm holds immense promise for biodiversity conservation. In response, we introduce BioAnalyst, the first Foundation Model tailored for biodiversity analysis and conservation planning. BioAnalyst employs a transformer-based architecture, pre-trained on extensive multi-modal datasets encompassing species occurrence records, remote sensing indicators, climate and environmental variables. BioAnalyst is designed for adaptability, allowing for fine-tuning of a range of downstream tasks, such as species distribution modelling, habitat suitability assessments, invasive species detection, and population trend forecasting. We evaluate the model's performance on two downstream use cases, demonstrating its generalisability compared to existing methods, particularly in data-scarce scenarios for two distinct use-cases, establishing a new accuracy baseline for ecological forecasting. By openly releasing BioAnalyst and its fine-tuning workflows to the scientific community, we aim to foster collaborative efforts in biodiversity modelling and advance AI-driven solutions to pressing ecological challenges.

  • 7 authors
·
Jul 11, 2025

Towards Scalable Foundation Model for Multi-modal and Hyperspectral Geospatial Data

Geospatial raster data, such as that collected by satellite-based imaging systems at different times and spectral bands, hold immense potential for enabling a wide range of high-impact applications. This potential stems from the rich information that is spatially and temporally contextualized across multiple channels and sensing modalities. Recent work has adapted existing self-supervised learning approaches for such geospatial data. However, they fall short of scalable model architectures, leading to inflexibility and computational inefficiencies when faced with an increasing number of channels and modalities. To address these limitations, we introduce Low-rank Efficient Spatial-Spectral Vision Transformer with three key innovations: i) the LESS Attention Block that approximates high-dimensional spatial-spectral attention through Kronecker's product of the low-dimensional spatial and spectral attention components; ii) the Continuous Positional-Channel Embedding Layer that preserves both the continuity and physical characteristics of each spatial-spectral patch; and iii) the Perception Field Mask that exploits local spatial dependencies by constraining attention to neighboring patches. To evaluate the proposed innovations, we construct GFM-Bench, which serves as a comprehensive benchmark for such geospatial raster data. We pretrain LESS ViT using a Hyperspectral Masked Autoencoder framework with integrated positional and channel masking strategies. Experimental results demonstrate that our proposed method achieves competitive performance against state-of-the-art multi-modal geospatial foundation models while outperforming them on cross-satellite generalization tasks with higher computational efficiency. The flexibility and extensibility of our framework make it a promising direction for future geospatial data analysis tasks that involve a wide range of modalities and channels.

  • 6 authors
·
Mar 17, 2025

ClimaX: A foundation model for weather and climate

Most state-of-the-art approaches for weather and climate modeling are based on physics-informed numerical models of the atmosphere. These approaches aim to model the non-linear dynamics and complex interactions between multiple variables, which are challenging to approximate. Additionally, many such numerical models are computationally intensive, especially when modeling the atmospheric phenomenon at a fine-grained spatial and temporal resolution. Recent data-driven approaches based on machine learning instead aim to directly solve a downstream forecasting or projection task by learning a data-driven functional mapping using deep neural networks. However, these networks are trained using curated and homogeneous climate datasets for specific spatiotemporal tasks, and thus lack the generality of numerical models. We develop and demonstrate ClimaX, a flexible and generalizable deep learning model for weather and climate science that can be trained using heterogeneous datasets spanning different variables, spatio-temporal coverage, and physical groundings. ClimaX extends the Transformer architecture with novel encoding and aggregation blocks that allow effective use of available compute while maintaining general utility. ClimaX is pre-trained with a self-supervised learning objective on climate datasets derived from CMIP6. The pre-trained ClimaX can then be fine-tuned to address a breadth of climate and weather tasks, including those that involve atmospheric variables and spatio-temporal scales unseen during pretraining. Compared to existing data-driven baselines, we show that this generality in ClimaX results in superior performance on benchmarks for weather forecasting and climate projections, even when pretrained at lower resolutions and compute budgets.

  • 5 authors
·
Jan 24, 2023