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Jul 31

Fine-Tuning a Local LLaMA-3 Large Language Model for Automated Privacy-Preserving Physician Letter Generation in Radiation Oncology

Generating physician letters is a time-consuming task in daily clinical practice. This study investigates local fine-tuning of large language models (LLMs), specifically LLaMA models, for physician letter generation in a privacy-preserving manner within the field of radiation oncology. Our findings demonstrate that base LLaMA models, without fine-tuning, are inadequate for effectively generating physician letters. The QLoRA algorithm provides an efficient method for local intra-institutional fine-tuning of LLMs with limited computational resources (i.e., a single 48 GB GPU workstation within the hospital). The fine-tuned LLM successfully learns radiation oncology-specific information and generates physician letters in an institution-specific style. ROUGE scores of the generated summary reports highlight the superiority of the 8B LLaMA-3 model over the 13B LLaMA-2 model. Further multidimensional physician evaluations of 10 cases reveal that, although the fine-tuned LLaMA-3 model has limited capacity to generate content beyond the provided input data, it successfully generates salutations, diagnoses and treatment histories, recommendations for further treatment, and planned schedules. Overall, clinical benefit was rated highly by the clinical experts (average score of 3.44 on a 4-point scale). With careful physician review and correction, automated LLM-based physician letter generation has significant practical value.

  • 15 authors
·
Aug 19, 2024

"Kelly is a Warm Person, Joseph is a Role Model": Gender Biases in LLM-Generated Reference Letters

Large Language Models (LLMs) have recently emerged as an effective tool to assist individuals in writing various types of content, including professional documents such as recommendation letters. Though bringing convenience, this application also introduces unprecedented fairness concerns. Model-generated reference letters might be directly used by users in professional scenarios. If underlying biases exist in these model-constructed letters, using them without scrutinization could lead to direct societal harms, such as sabotaging application success rates for female applicants. In light of this pressing issue, it is imminent and necessary to comprehensively study fairness issues and associated harms in this real-world use case. In this paper, we critically examine gender biases in LLM-generated reference letters. Drawing inspiration from social science findings, we design evaluation methods to manifest biases through 2 dimensions: (1) biases in language style and (2) biases in lexical content. We further investigate the extent of bias propagation by analyzing the hallucination bias of models, a term that we define to be bias exacerbation in model-hallucinated contents. Through benchmarking evaluation on 2 popular LLMs- ChatGPT and Alpaca, we reveal significant gender biases in LLM-generated recommendation letters. Our findings not only warn against using LLMs for this application without scrutinization, but also illuminate the importance of thoroughly studying hidden biases and harms in LLM-generated professional documents.

  • 6 authors
·
Oct 13, 2023

Why Do Large Language Models (LLMs) Struggle to Count Letters?

Large Language Models (LLMs) have achieved unprecedented performance on many complex tasks, being able, for example, to answer questions on almost any topic. However, they struggle with other simple tasks, such as counting the occurrences of letters in a word, as illustrated by the inability of many LLMs to count the number of "r" letters in "strawberry". Several works have studied this problem and linked it to the tokenization used by LLMs, to the intrinsic limitations of the attention mechanism, or to the lack of character-level training data. In this paper, we conduct an experimental study to evaluate the relations between the LLM errors when counting letters with 1) the frequency of the word and its components in the training dataset and 2) the complexity of the counting operation. We present a comprehensive analysis of the errors of LLMs when counting letter occurrences by evaluating a representative group of models over a large number of words. The results show a number of consistent trends in the models evaluated: 1) models are capable of recognizing the letters but not counting them; 2) the frequency of the word and tokens in the word does not have a significant impact on the LLM errors; 3) there is a positive correlation of letter frequency with errors, more frequent letters tend to have more counting errors, 4) the errors show a strong correlation with the number of letters or tokens in a word and 5) the strongest correlation occurs with the number of letters with counts larger than one, with most models being unable to correctly count words in which letters appear more than twice.

  • 5 authors
·
Dec 19, 2024

OpenFS: Multi-Hand-Capable Fingerspelling Recognition with Implicit Signing-Hand Detection and Frame-Wise Letter-Conditioned Synthesis

Fingerspelling is a component of sign languages in which words are spelled out letter by letter using specific hand poses. Automatic fingerspelling recognition plays a crucial role in bridging the communication gap between Deaf and hearing communities, yet it remains challenging due to the signing-hand ambiguity issue, the lack of appropriate training losses, and the out-of-vocabulary (OOV) problem. Prior fingerspelling recognition methods rely on explicit signing-hand detection, which often leads to recognition failures, and on a connectionist temporal classification (CTC) loss, which exhibits the peaky behavior problem. To address these issues, we develop OpenFS, an open-source approach for fingerspelling recognition and synthesis. We propose a multi-hand-capable fingerspelling recognizer that supports both single- and multi-hand inputs and performs implicit signing-hand detection by incorporating a dual-level positional encoding and a signing-hand focus (SF) loss. The SF loss encourages cross-attention to focus on the signing hand, enabling implicit signing-hand detection during recognition. Furthermore, without relying on the CTC loss, we introduce a monotonic alignment (MA) loss that enforces the output letter sequence to follow the temporal order of the input pose sequence through cross-attention regularization. In addition, we propose a frame-wise letter-conditioned generator that synthesizes realistic fingerspelling pose sequences for OOV words. This generator enables the construction of a new synthetic benchmark, called FSNeo. Through comprehensive experiments, we demonstrate that our approach achieves state-of-the-art performance in recognition and validate the effectiveness of the proposed recognizer and generator. Codes and data are available in: https://github.com/AIRC-KETI/OpenFS.

  • 3 authors
·
Feb 26

A Unified Framework and Comparative Study of Decentralized Finance Derivatives Protocols

Decentralized Finance (DeFi) applications introduce novel financial instruments replicating and extending traditional ones through blockchain-based smart contracts. Among these applications, DeFi derivatives protocols enable the creation and trading of decentralized derivative instruments whose value depends on underlying cryptoassets, indices, or other reference variables. Despite their growing significance, however, they remain relatively understudied compared to other DeFi protocols, such as lending protocols and decentralized exchanges. This paper systematically analyzes DeFi derivatives protocols, categorized into perpetuals, options, and synthetics, with the aim of comparing their instrument structures, protocol mechanisms, operational dynamics, and economic agents. We provide a formal characterization of the main classes of decentralized derivative instruments and develop a protocol-agnostic framework that connects instrument-level specifications, market-state variables, and protocol-level mechanisms. We complement the analytical framework with numerical simulations that evaluate how derivative positions evolve under varying economic conditions, including changes in underlying asset prices, volatility, protocol-specific fees, and leverage. Overall, this study provides a structured analytical framework for understanding and comparing the design and functioning of decentralized finance derivatives protocols.

  • 4 authors
·
May 3