Daily Papers

Despite the progress made by multimodal large language models (MLLMs) in computational pathology, they remain limited by a predominant focus on patch-level analysis, missing essential contextual information at the whole-slide level. The lack of large-scale instruction datasets and the gigapixel scale of whole slide images (WSIs) pose significant developmental challenges. In this paper, we present SlideChat, the first vision-language assistant capable of understanding gigapixel whole-slide images, exhibiting excellent multimodal conversational capability and response complex instruction across diverse pathology scenarios. To support its development, we created SlideInstruction, the largest instruction-following dataset for WSIs consisting of 4.2K WSI captions and 176K VQA pairs with multiple categories. Furthermore, we propose SlideBench, a multimodal benchmark that incorporates captioning and VQA tasks to assess SlideChat's capabilities in varied clinical settings such as microscopy, diagnosis. Compared to both general and specialized MLLMs, SlideChat exhibits exceptional capabilities achieving state-of-the-art performance on 18 of 22 tasks. For example, it achieved an overall accuracy of 81.17% on SlideBench-VQA (TCGA), and 54.15% on SlideBench-VQA (BCNB). We will fully release SlideChat, SlideInstruction and SlideBench as open-source resources to facilitate research and development in computational pathology.

The application of large vision-language models to computational pathology holds great promise for diagnostic assistants but faces a critical computational bottleneck: the gigapixel scale of Whole Slide Images (WSIs). A single WSI typically contains over 105 patches, creating sequence lengths that exceed the constraints of standard Transformer architectures. Existing solutions often resort to spatial sampling, which risks discarding diagnostically critical evidence. To address this, we propose TC-SSA (Token Compression via Semantic Slot Aggregation), a learnable token compression framework that aggregates patch features into a fixed number of semantic slots. A gated routing module assigns patches to slots using sparse Top-2 routing, followed by weighted aggregation, enabling global slide coverage under a strict token budget. The resulting representation retains diagnostically relevant information while reducing the number of visual tokens to 1.7% of the original sequence. On the SlideBench(TCGA), our model achieves 78.34% overall accuracy and 77.14% on the diagnosis subset, outperforming sampling-based baselines under comparable token budgets. The method also generalizes to MIL classification, reaching AUC of 95.83% on TCGA-BRCA, 98.27% on TCGA-NSCLC and 79.80% on PANDA. These results suggest that learnable semantic aggregation provides an effective trade-off between efficiency and diagnostic performance for gigapixel pathology reasoning.

Vision-as-inverse-graphics, the concept of reconstructing an image as an editable graphics program is a long-standing goal of computer vision. Yet even strong VLMs aren't able to achieve this in one-shot as they lack fine-grained spatial and physical grounding capability. Our key insight is that closing this gap requires interleaved multimodal reasoning through iterative execution and verification. Stemming from this, we present VIGA (Vision-as-Inverse-Graphic Agent) that starts from an empty world and reconstructs or edits scenes through a closed-loop write-run-render-compare-revise procedure. To support long-horizon reasoning, VIGA combines (i) a skill library that alternates generator and verifier roles and (ii) an evolving context memory that contains plans, code diffs, and render history. VIGA is task-agnostic as it doesn't require auxiliary modules, covering a wide range of tasks such as 3D reconstruction, multi-step scene editing, 4D physical interaction, and 2D document editing, etc. Empirically, we found VIGA substantially improves one-shot baselines on BlenderGym (35.32%) and SlideBench (117.17%). Moreover, VIGA is also model-agnostic as it doesn't require finetuning, enabling a unified protocol to evaluate heterogeneous foundation VLMs. To better support this protocol, we introduce BlenderBench, a challenging benchmark that stress-tests interleaved multimodal reasoning with graphics engine, where VIGA improves by 124.70%.