Daily Papers

Chain-of-thought (CoT) reasoning has been widely applied in the mathematical reasoning of Large Language Models (LLMs). Recently, the introduction of derivative process supervision on CoT trajectories has sparked discussions on enhancing scaling capabilities during test time, thereby boosting the potential of these models. However, in multimodal mathematical reasoning, the scarcity of high-quality CoT training data has hindered existing models from achieving high-precision CoT reasoning and has limited the realization of reasoning potential during test time. In this work, we propose a three-module synthesis strategy that integrates CoT distillation, trajectory-format rewriting, and format unification. It results in a high-quality CoT reasoning instruction fine-tuning dataset in multimodal mathematics, MMathCoT-1M. We comprehensively validate the state-of-the-art (SOTA) performance of the trained URSA-7B model on multiple multimodal mathematical benchmarks. For test-time scaling, we introduce a data synthesis strategy that automatically generates process annotation datasets, known as DualMath-1.1M, focusing on both interpretation and logic. By further training URSA-7B on DualMath-1.1M, we transition from CoT reasoning capabilities to robust supervision abilities. The trained URSA-RM-7B acts as a verifier, effectively enhancing the performance of URSA-7B at test time. URSA-RM-7B also demonstrates excellent out-of-distribution (OOD) verifying capabilities, showcasing its generalization. Model weights, training data and code will be open-sourced.

Synthesis planning aiming to find pathways of reactions for a target molecule is one of the most important and challenging tasks in drug discovery. Recent progress has produced both specialized deep-learning retrosynthesis systems and general-purpose large language models, but objective comparison remains difficult due to the lack of flexible, chemically interpretable benchmarking protocols. In the current study, we are introducing the URSA (Utilitarian RetroSynthesis Assessment) evaluation framework that provides the opportunity to benchmark the synthetic routes not only from a formal perspective, such as convergence to commercially available starting materials, but also from a chemical plausibility perspective, mimicking the way expert chemists evaluate the reactions and routes. The study covers a comprehensive evaluation of both conventional end-to-end retrosynthesis solutions and LLMs for the synthesis planning task on a set of novel, diverse target molecules with undisclosed synthetic routes, which represent realistic tasks in the daily drug design routine. We find that while LLMs can support high-level strategic planning, they currently underperform specialized retrosynthesis models in reliably solving synthesis planning tasks.

Markerless methods for animal posture tracking have been rapidly developing recently, but frameworks and benchmarks for tracking large animal groups in 3D are still lacking. To overcome this gap in the literature, we present 3D-MuPPET, a framework to estimate and track 3D poses of up to 10 pigeons at interactive speed using multiple camera views. We train a pose estimator to infer 2D keypoints and bounding boxes of multiple pigeons, then triangulate the keypoints to 3D. For identity matching of individuals in all views, we first dynamically match 2D detections to global identities in the first frame, then use a 2D tracker to maintain IDs across views in subsequent frames. We achieve comparable accuracy to a state of the art 3D pose estimator in terms of median error and Percentage of Correct Keypoints. Additionally, we benchmark the inference speed of 3D-MuPPET, with up to 9.45 fps in 2D and 1.89 fps in 3D, and perform quantitative tracking evaluation, which yields encouraging results. Finally, we showcase two novel applications for 3D-MuPPET. First, we train a model with data of single pigeons and achieve comparable results in 2D and 3D posture estimation for up to 5 pigeons. Second, we show that 3D-MuPPET also works in outdoors without additional annotations from natural environments. Both use cases simplify the domain shift to new species and environments, largely reducing annotation effort needed for 3D posture tracking. To the best of our knowledge we are the first to present a framework for 2D/3D animal posture and trajectory tracking that works in both indoor and outdoor environments for up to 10 individuals. We hope that the framework can open up new opportunities in studying animal collective behaviour and encourages further developments in 3D multi-animal posture tracking.

We benchmark foundation models image embeddings for classification and retrieval in e-Commerce, evaluating their suitability for real-world applications. Our study spans embeddings from pre-trained convolutional and transformer models trained via supervised, self-supervised, and text-image contrastive learning. We assess full fine-tuning and transfer learning (top-tuning) on six diverse e-Commerce datasets: fashion, consumer goods, cars, food, and retail. Results show full fine-tuning consistently performs well, while text-image and self-supervised embeddings can match its performance with less training. While supervised embeddings remain stable across architectures, SSL and contrastive embeddings vary significantly, often benefiting from top-tuning. Top-tuning emerges as an efficient alternative to full fine-tuning, reducing computational costs. We also explore cross-tuning, noting its impact depends on dataset characteristics. Our findings offer practical guidelines for embedding selection and fine-tuning strategies, balancing efficiency and performance.

An important emerging application of coding agents is agent optimization: the iterative improvement of a target agent through edit-execute-evaluate cycles. Despite its relevance, the community lacks a systematic understanding of coding agent performance on this task. Agent optimization differs fundamentally from conventional software engineering: the target agent interleaves deterministic code with stochastic LLM completions, requiring structured capture of both intermediate reasoning and downstream execution outcomes. To address these challenges, we introduce VERO (Versioning, Rewards, and Observations), which provides (1) a reproducible evaluation harness with versioned agent snapshots, budget-controlled evaluation, and structured execution traces, and (2) a benchmark suite of target agents and tasks with reference evaluation procedures. Using VERO, we conduct an empirical study comparing optimizer configurations across tasks and analyzing which modifications reliably improve target agent performance. We release VERO to support research on agent optimization as a core capability for coding agents.

Despite the growing need for data of more and more sophisticated 3D reconstruction pipelines, we can still observe a scarcity of suitable public datasets. Existing 3D datasets are either low resolution, limited to a small amount of scenes, based on images of varying quality because retrieved from the internet, or limited to specific capturing scenarios. Motivated by this lack of suitable 3D datasets, we captured TerraSky3D, a high-resolution large-scale 3D reconstruction dataset comprising 50,000 images divided into 150 ground, aerial, and mixed scenes. The dataset focuses on European landmarks and comes with curated calibration data, camera poses, and depth maps. TerraSky3D tries to answer the need for challenging dataset that can be used to train and evaluate 3D reconstruction-related pipelines.

Machine Learning (ML) workloads have rapidly grown in importance, but raised concerns about their carbon footprint. Four best practices can reduce ML training energy by up to 100x and CO2 emissions up to 1000x. By following best practices, overall ML energy use (across research, development, and production) held steady at <15% of Google's total energy use for the past three years. If the whole ML field were to adopt best practices, total carbon emissions from training would reduce. Hence, we recommend that ML papers include emissions explicitly to foster competition on more than just model quality. Estimates of emissions in papers that omitted them have been off 100x-100,000x, so publishing emissions has the added benefit of ensuring accurate accounting. Given the importance of climate change, we must get the numbers right to make certain that we work on its biggest challenges.

Vision-based 3D human motion capture from videos remains a challenge in computer vision. Traditional 3D pose estimation approaches often ignore the temporal consistency between frames, causing implausible and jittery motion. The emerging field of kinematics-based 3D motion capture addresses these issues by estimating the temporal transitioning between poses instead. A major drawback in current kinematics approaches is their reliance on Euler angles. Despite their simplicity, Euler angles suffer from discontinuity that leads to unstable motion reconstructions, especially in online settings where trajectory refinement is unavailable. Contrarily, quaternions have no discontinuity and can produce continuous transitions between poses. In this paper, we propose QuaMo, a novel Quaternion Motions method using quaternion differential equations (QDE) for human kinematics capture. We utilize the state-space model, an effective system for describing real-time kinematics estimations, with quaternion state and the QDE describing quaternion velocity. The corresponding angular acceleration is computed from a meta-PD controller with a novel acceleration enhancement that adaptively regulates the control signals as the human quickly changes to a new pose. Unlike previous work, our QDE is solved under the quaternion unit-sphere constraint that results in more accurate estimations. Experimental results show that our novel formulation of the QDE with acceleration enhancement accurately estimates 3D human kinematics with no discontinuity and minimal implausibilities. QuaMo outperforms comparable state-of-the-art methods on multiple datasets, namely Human3.6M, Fit3D, SportsPose and AIST. The code is available at https://github.com/cuongle1206/QuaMo

The rise of imaging techniques such as optical coherence tomography (OCT) and advances in deep learning (DL) have enabled clinicians and researchers to streamline retinal disease staging. A popular DL approach is self-supervised learning (SSL), where models learn from vast amounts of unlabeled data, avoiding costly annotation. SSL has allowed the development of foundation models (FMs), large models that can be used for a variety of downstream tasks. However, existing FMs for OCT, trained solely on image data, lack a comprehensive and robust semantic understanding of images, as evidenced by their downstream performance (especially for complex tasks), and thus require supervised fine-tuning (which may be unfeasible) to better adapt to specific applications and populations. To address this, we propose RetFiner, an SSL vision-language refinement scheme that improves the representations of existing FMs and enables their efficient and direct adaptation to specific populations for improved downstream performance. Our method uses a diverse set of training objectives which take advantage of the rich supervisory signal found in textual data. We tested RetFiner on the retinal FMs RETFound, UrFound, and VisionFM, showing significant improvements in linear probing performance on seven highly diverse OCT classification tasks, with an average increase of 5.8, 3.9, and 2.1 percentage points over their baselines, respectively. Our code and model weights are publicly available at https://github.com/ronnief1/RetFiner.

We present PoliTok-DE, a large-scale multimodal dataset (video, audio, images, text) of TikTok posts related to the 2024 Saxony state election in Germany. The corpus contains over 195,000 posts published between 01.07.2024 and 30.11.2024, of which over 18,000 (17.3%) were subsequently deleted from the platform. Posts were identified via the TikTok research API and complemented with web scraping to retrieve full multimodal media and metadata. PoliTok-DE supports computational social science across substantive and methodological agendas: substantive work on intolerance and political communication; methodological work on platform policies around deleted content and qualitative-quantitative multimodal research. To illustrate one possible analysis, we report a case study on the co-occurrence of intolerance and entertainment using an annotated subset. The dataset of post IDs is publicly available on Hugging Face, and full content can be hydrated with our provided code. Access to the deleted content is restricted, and can be requested for research purposes.

We propose PyTorchGeoNodes, a differentiable module for reconstructing 3D objects from images using interpretable shape programs. In comparison to traditional CAD model retrieval methods, the use of shape programs for 3D reconstruction allows for reasoning about the semantic properties of reconstructed objects, editing, low memory footprint, etc. However, the utilization of shape programs for 3D scene understanding has been largely neglected in past works. As our main contribution, we enable gradient-based optimization by introducing a module that translates shape programs designed in Blender, for example, into efficient PyTorch code. We also provide a method that relies on PyTorchGeoNodes and is inspired by Monte Carlo Tree Search (MCTS) to jointly optimize discrete and continuous parameters of shape programs and reconstruct 3D objects for input scenes. In our experiments, we apply our algorithm to reconstruct 3D objects in the ScanNet dataset and evaluate our results against CAD model retrieval-based reconstructions. Our experiments indicate that our reconstructions match well the input scenes while enabling semantic reasoning about reconstructed objects.

Natural structural materials, such as bone and wood, can autonomously adapt their mechanical properties in response to loading to prevent failure. They smartly control the addition of material in locations of high stress by utilizing locally available resources guided by biological signals. On the contrary, synthetic structural materials have unchanging mechanical properties limiting their mechanical performance and service life. Here, a material system that autonomously adapts its mechanical properties in response to mechanical loading is reported inspired by the mineralization process of bone. It is observed that charges from piezoelectric scaffolds can induce mineralization from media with mineral ions. The material system adapts to mechanical loading by inducing mineral deposition in proportion to the magnitude of the loading and the resulting piezoelectric charges. Moreover, the mechanism allows a simple one-step route for making graded materials by controlling stress distribution along the scaffold. The findings can pave the way for a new class of self-adaptive materials that reinforce the region of high stress or induce deposition of minerals on the damaged areas from the increase in stress to prevent/mitigate failure. They can also contribute to addressing the current challenges of synthetic materials for load-bearing applications from self-adaptive capabilities.

Diffusion models have been widely adopted in image generation, producing higher-quality and more diverse samples than generative adversarial networks (GANs). We introduce a latent diffusion model (LDM) for precipitation nowcasting - short-term forecasting based on the latest observational data. The LDM is more stable and requires less computation to train than GANs, albeit with more computationally expensive generation. We benchmark it against the GAN-based Deep Generative Models of Rainfall (DGMR) and a statistical model, PySTEPS. The LDM produces more accurate precipitation predictions, while the comparisons are more mixed when predicting whether the precipitation exceeds predefined thresholds. The clearest advantage of the LDM is that it generates more diverse predictions than DGMR or PySTEPS. Rank distribution tests indicate that the distribution of samples from the LDM accurately reflects the uncertainty of the predictions. Thus, LDMs are promising for any applications where uncertainty quantification is important, such as weather and climate.

Neural network training is commonly accelerated by using multiple synchronized workers to compute gradient updates in parallel. Asynchronous methods remove synchronization overheads and improve hardware utilization at the cost of introducing gradient delay, which impedes optimization and can lead to lower final model performance. We introduce Adaptive Braking (AB), a modification for momentum-based optimizers that mitigates the effects of gradient delay. AB dynamically scales the gradient based on the alignment of the gradient and the velocity. This can dampen oscillations along high curvature directions of the loss surface, stabilizing and accelerating asynchronous training. We show that applying AB on top of SGD with momentum enables training ResNets on CIFAR-10 and ImageNet-1k with delays D geq 32 update steps with minimal drop in final test accuracy.

New hardware can substantially increase the speed and efficiency of deep neural network training. To guide the development of future hardware architectures, it is pertinent to explore the hardware and machine learning properties of alternative training algorithms. In this work we evaluate the use of small batch, fine-grained Pipelined Backpropagation, an asynchronous pipeline parallel training algorithm that has significant hardware advantages. We introduce two methods, Spike Compensation and Linear Weight Prediction, that effectively mitigate the downsides caused by the asynchronicity of Pipelined Backpropagation and outperform existing techniques in our setting. We show that appropriate normalization and small batch sizes can also aid training. With our methods, fine-grained Pipelined Backpropagation using a batch size of one can match the accuracy of SGD for multiple networks trained on CIFAR-10 and ImageNet. Simple scaling rules allow the use of existing hyperparameters for traditional training without additional tuning.

Online Normalization is a new technique for normalizing the hidden activations of a neural network. Like Batch Normalization, it normalizes the sample dimension. While Online Normalization does not use batches, it is as accurate as Batch Normalization. We resolve a theoretical limitation of Batch Normalization by introducing an unbiased technique for computing the gradient of normalized activations. Online Normalization works with automatic differentiation by adding statistical normalization as a primitive. This technique can be used in cases not covered by some other normalizers, such as recurrent networks, fully connected networks, and networks with activation memory requirements prohibitive for batching. We show its applications to image classification, image segmentation, and language modeling. We present formal proofs and experimental results on ImageNet, CIFAR, and PTB datasets.

High dynamic range (HDR) imagery offers a rich and faithful representation of scene radiance, but remains challenging for generative models due to its mismatch with the bounded, perceptually compressed data on which these models are trained. A natural solution is to learn new representations for HDR, which introduces additional complexity and data requirements. In this work, we show that HDR generation can be achieved in a much simpler way by leveraging the strong visual priors already captured by pretrained generative models. We observe that a logarithmic encoding widely used in cinematic pipelines maps HDR imagery into a distribution that is naturally aligned with the latent space of these models, enabling direct adaptation via lightweight fine-tuning without retraining an encoder. To recover details that are not directly observable in the input, we further introduce a training strategy based on camera-mimicking degradations that encourages the model to infer missing high dynamic range content from its learned priors. Combining these insights, we demonstrate high-quality HDR video generation using a pretrained video model with minimal adaptation, achieving strong results across diverse scenes and challenging lighting conditions. Our results indicate that HDR, despite representing a fundamentally different image formation regime, can be handled effectively without redesigning generative models, provided that the representation is chosen to align with their learned priors.

Audio-Visual Foundation Models, which are pretrained to jointly generate sound and visual content, have recently shown an unprecedented ability to model multi-modal generation and editing, opening new opportunities for downstream tasks. Among these tasks, video dubbing could greatly benefit from such priors, yet most existing solutions still rely on complex, task-specific pipelines that struggle in real-world settings. In this work, we introduce a single-model approach that adapts a foundational audio-video diffusion model for video-to-video dubbing via a lightweight LoRA. The LoRA enables the model to condition on an input audio-video while jointly generating translated audio and synchronized facial motion. To train this LoRA, we leverage the generative model itself to synthesize paired multilingual videos of the same speaker. Specifically, we generate multilingual videos with language switches within a single clip, and then inpaint the face and audio in each half to match the language of the other half. By leveraging the rich generative prior of the audio-visual model, our approach preserves speaker identity and lip synchronization while remaining robust to complex motion and real-world dynamics. We demonstrate that our approach produces high-quality dubbed videos with improved visual fidelity, lip synchronization, and robustness compared to existing dubbing pipelines.

Training large text-to-image models requires high-quality, curated datasets with diverse content and detailed captions. Yet the cost and complexity of collecting, filtering, deduplicating, and re-captioning such corpora at scale hinders open and reproducible research in the field. We introduce MONET, an open Apache 2.0 dataset of approx. 104.9M image--text pairs collected from 2.9B raw pairs across heterogeneous open sources through successive stages of safety filtering, domain-based filtering, exact and near-duplicate removal, and re-captioning with multiple vision-language models covering short to long-form descriptions, and further augmented with synthetically generated samples. Each image is shipped with pre-computed embeddings and annotations to accelerate downstream use. To validate the effectiveness of MONET, we train a 4B-parameter latent diffusion model exclusively on it and reach competitive GenEval and DPG scores, demonstrating that our dataset lowers the barrier to large-scale, reproducible text-to-image research.

Retrieval-Augmented Generation (RAG) mitigates hallucinations in Large Language Models (LLMs) by grounding the generation process on external knowledge. However, standard RAG approaches struggle with multi-hop reasoning. While recent graph-based RAG methods improve the retrieval of interconnected chunks, they often rely on computationally expensive and error-prone LLM-based extraction pipelines. To address these issues, we propose TIGRAG (Token-Induced GraphRAG), an efficient graph-augmented RAG framework based on a token co-occurrence Knowledge Graph. TIGRAG directly models topological relationships between tokens using sliding-window co-occurrence statistics, thus enabling scalable graph construction. During inference, it combines graph-based semantic expansion and neural reranking to retrieve interconnected evidence for multi-hop reasoning. Specifically, it introduces an iterative entity-driven retrieval strategy that progressively expands the query using bridging entities extracted from previously retrieved contexts. We evaluated TIGRAG on three widely adopted multi-hop Question Answering (QA) benchmarks. Experimental results demonstrated that our framework consistently outperforms dense retrieval and graph-based RAG methods in both retrieval and downstream QA tasks, while substantially reducing indexing time, inference latency, and prompt footprint.

Chiral magnons, the quanta of handed spin waves, transport spin angular momentum without energy loss due to Joule heating. The recently discovered altermagnets were proposed to host chiral magnons arising from a non-relativistic exchange mechanism, similar to that in ferromagnets but without net magnetization, offering a stray-field-free platform for efficient magnon spin-current manipulation. In this work, we directly observed chiral magnons in the altermagnetic prototype MnTe using polarized inelastic neutron scattering. Furthermore, the magnon chirality was found to be reversibly switched by magnetic-field control, establishing a robust foundation for functional altermagnetic magnonics.

Gaussian Splatting has emerged as a high-performance technique for novel view synthesis, enabling real-time rendering and high-quality reconstruction of small scenes. However, scaling to larger environments has so far relied on partitioning the scene into chunks -- a strategy that introduces artifacts at chunk boundaries, complicates training across varying scales, and is poorly suited to unstructured scenarios such as city-scale flyovers combined with street-level views. Moreover, rendering remains fundamentally limited by GPU memory, as all visible chunks must reside in VRAM simultaneously. We introduce A LoD of Gaussians, a framework for training and rendering ultra-large-scale Gaussian scenes on a single consumer-grade GPU -- without partitioning. Our method stores the full scene out-of-core (e.g., in CPU memory) and trains a Level-of-Detail (LoD) representation directly, dynamically streaming only the relevant Gaussians. A hybrid data structure combining Gaussian hierarchies with Sequential Point Trees enables efficient, view-dependent LoD selection, while a lightweight caching and view scheduling system exploits temporal coherence to support real-time streaming and rendering. Together, these innovations enable seamless multi-scale reconstruction and interactive visualization of complex scenes -- from broad aerial views to fine-grained ground-level details.

Legacy software systems, written in outdated languages like MUMPS and mainframe assembly, pose challenges in efficiency, maintenance, staffing, and security. While LLMs offer promise for modernizing these systems, their ability to understand legacy languages is largely unknown. This paper investigates the utilization of LLMs to generate documentation for legacy code using two datasets: an electronic health records (EHR) system in MUMPS and open-source applications in IBM mainframe Assembly Language Code (ALC). We propose a prompting strategy for generating line-wise code comments and a rubric to evaluate their completeness, readability, usefulness, and hallucination. Our study assesses the correlation between human evaluations and automated metrics, such as code complexity and reference-based metrics. We find that LLM-generated comments for MUMPS and ALC are generally hallucination-free, complete, readable, and useful compared to ground-truth comments, though ALC poses challenges. However, no automated metrics strongly correlate with comment quality to predict or measure LLM performance. Our findings highlight the limitations of current automated measures and the need for better evaluation metrics for LLM-generated documentation in legacy systems.

As a direct consequence of the no-cloning theorem, the deterministic amplification as in classical communication is impossible for quantum states. This calls for more advanced techniques in a future global quantum network, e.g. for cloud quantum computing. A unique solution is the teleportation of an entangled state, i.e. entanglement swapping, representing the central resource to relay entanglement between distant nodes. Together with entanglement purification and a quantum memory it constitutes a so-called quantum repeater. Since the aforementioned building blocks have been individually demonstrated in laboratory setups only, the applicability of the required technology in real-world scenarios remained to be proven. Here we present a free-space entanglement-swapping experiment between the Canary Islands of La Palma and Tenerife, verifying the presence of quantum entanglement between two previously independent photons separated by 143 km. We obtained an expectation value for the entanglement-witness operator, more than 6 standard deviations beyond the classical limit. By consecutive generation of the two required photon pairs and space-like separation of the relevant measurement events, we also showed the feasibility of the swapping protocol in a long-distance scenario, where the independence of the nodes is highly demanded. Since our results already allow for efficient implementation of entanglement purification, we anticipate our assay to lay the ground for a fully-fledged quantum repeater over a realistic high-loss and even turbulent quantum channel.

We trained a convolutional neural network (CNN) to map raw pixels from a single front-facing camera directly to steering commands. This end-to-end approach proved surprisingly powerful. With minimum training data from humans the system learns to drive in traffic on local roads with or without lane markings and on highways. It also operates in areas with unclear visual guidance such as in parking lots and on unpaved roads. The system automatically learns internal representations of the necessary processing steps such as detecting useful road features with only the human steering angle as the training signal. We never explicitly trained it to detect, for example, the outline of roads. Compared to explicit decomposition of the problem, such as lane marking detection, path planning, and control, our end-to-end system optimizes all processing steps simultaneously. We argue that this will eventually lead to better performance and smaller systems. Better performance will result because the internal components self-optimize to maximize overall system performance, instead of optimizing human-selected intermediate criteria, e.g., lane detection. Such criteria understandably are selected for ease of human interpretation which doesn't automatically guarantee maximum system performance. Smaller networks are possible because the system learns to solve the problem with the minimal number of processing steps. We used an NVIDIA DevBox and Torch 7 for training and an NVIDIA DRIVE(TM) PX self-driving car computer also running Torch 7 for determining where to drive. The system operates at 30 frames per second (FPS).

Controlling video and audio generation requires diverse modalities, from depth and pose to camera trajectories and audio transformations, yet existing approaches either train a single monolithic model for a fixed set of controls or introduce costly architectural changes for each new modality. We introduce AVControl, a lightweight, extendable framework built on LTX-2, a joint audio-visual foundation model, where each control modality is trained as a separate LoRA on a parallel canvas that provides the reference signal as additional tokens in the attention layers, requiring no architectural changes beyond the LoRA adapters themselves. We show that simply extending image-based in-context methods to video fails for structural control, and that our parallel canvas approach resolves this. On the VACE Benchmark, we outperform all evaluated baselines on depth- and pose-guided generation, inpainting, and outpainting, and show competitive results on camera control and audio-visual benchmarks. Our framework supports a diverse set of independently trained modalities: spatially-aligned controls such as depth, pose, and edges, camera trajectory with intrinsics, sparse motion control, video editing, and, to our knowledge, the first modular audio-visual controls for a joint generation model. Our method is both compute- and data-efficient: each modality requires only a small dataset and converges within a few hundred to a few thousand training steps, a fraction of the budget of monolithic alternatives. We publicly release our code and trained LoRA checkpoints.

Artificial intelligence (AI) has become a fundamental tool for assisting clinicians in analyzing ophthalmic images, such as optical coherence tomography (OCT). However, developing AI models often requires extensive annotation, and existing models tend to underperform on independent, unseen data. Foundation models (FMs), large AI models trained on vast unlabeled datasets, have shown promise in overcoming these challenges. Nonetheless, available FMs for ophthalmology lack extensive validation, especially for segmentation tasks, and focus on a single imaging modality. In this context, we propose MIRAGE, a novel multimodal FM for the analysis of OCT and scanning laser ophthalmoscopy (SLO) images. Additionally, we propose a new evaluation benchmark with OCT/SLO classification and segmentation tasks. The comparison with general and specialized FMs and segmentation methods shows the superiority of MIRAGE in both types of tasks, highlighting its suitability as a basis for the development of robust AI systems for retinal OCT image analysis. Both MIRAGE and the evaluation benchmark are publicly available: https://github.com/j-morano/MIRAGE.

This work introduces HistNERo, the first Romanian corpus for Named Entity Recognition (NER) in historical newspapers. The dataset contains 323k tokens of text, covering more than half of the 19th century (i.e., 1817) until the late part of the 20th century (i.e., 1990). Eight native Romanian speakers annotated the dataset with five named entities. The samples belong to one of the following four historical regions of Romania, namely Bessarabia, Moldavia, Transylvania, and Wallachia. We employed this proposed dataset to perform several experiments for NER using Romanian pre-trained language models. Our results show that the best model achieved a strict F1-score of 55.69%. Also, by reducing the discrepancies between regions through a novel domain adaption technique, we improved the performance on this corpus to a strict F1-score of 66.80%, representing an absolute gain of more than 10%.

The advent of new generation radio telescopes is opening new possibilities on the classification and study of extragalactic high-energy sources, specially the underrepresented ones like radio galaxies. Among these, Giant Radio Galaxies (GRG, larger than 0.7 Mpc) are among the most extreme manifestations of the accretion/ejection processes on supermassive black holes. Our recent studies have shown that GRG can be up to four times more abundant in hard X-ray selected (i.e. from INTEGRAL/IBIS and Swift/BAT at >20 keV) samples and, most interestingly, the majority of them present signs of restarted radio activity. This makes them the ideal test-bed to study the so far unknown duty cycle of jets in active galactic nuclei. Open questions in the field include: How and when jets are restarted? How jets evolve and what's their dynamic? What is the jet's duty cycle and what triggers them? Our group has recently collected a wealth of radio data on these high-energy selected GRGs, allowing us to study their jet formation and evolution from the pc to kpc scales, across different activity epochs. In particular, thanks to our EVN large programme, we were able to probe the new radio phase in the core of these giants. Furthermore, we are devoting an effort to the exploitation of new radio surveys data for the discovery of new classes of counterparts of Fermi/LAT catalogues. In particular, we are unveiling the hidden population of radio galaxies associated with gamma-ray sources.

Clinicians spend a significant amount of time reviewing medical images and transcribing their findings regarding patient diagnosis, referral and treatment in text form. Vision-language models (VLMs), which automatically interpret images and summarize their findings as text, have enormous potential to alleviate clinical workloads and increase patient access to high-quality medical care. While foundational models have stirred considerable interest in the medical community, it is unclear whether their general capabilities translate to real-world clinical utility. In this work, we show that foundation VLMs markedly underperform compared to practicing ophthalmologists on specialist tasks crucial to the care of patients with age-related macular degeneration (AMD). To address this, we initially identified the essential capabilities required for image-based clinical decision-making, and then developed a curriculum to selectively train VLMs in these skills. The resulting model, RetinaVLM, can be instructed to write reports that significantly outperform those written by leading foundation medical VLMs in disease staging (F1 score of 0.63 vs. 0.11) and patient referral (0.67 vs. 0.39), and approaches the diagnostic performance of junior ophthalmologists (who achieve 0.77 and 0.78 on the respective tasks). Furthermore, in a reader study involving two senior ophthalmologists with up to 32 years of experience, RetinaVLM's reports were found to be similarly correct (78.6% vs. 82.1%) and complete (both 78.6%) as reports written by junior ophthalmologists with up to 10 years of experience. These results demonstrate that our curriculum-based approach provides a blueprint for specializing generalist foundation medical VLMs to handle real-world clinical tasks.

Clinical trials disruption has always represented a non negligible part of the ending of interventional studies. While the SARS-CoV-2 (COVID-19) pandemic has led to an impressive and unprecedented initiation of clinical research, it has also led to considerable disruption of clinical trials in other disease areas, with around 80% of non-COVID-19 trials stopped or interrupted during the pandemic. In many cases the disrupted trials will not have the planned statistical power necessary to yield interpretable results. This paper describes methods to compensate for the information loss arising from trial disruptions by incorporating additional information available from auxiliary data sources. The methods described include the use of auxiliary data on baseline and early outcome data available from the trial itself and frequentist and Bayesian approaches for the incorporation of information from external data sources. The methods are illustrated by application to the analysis of artificial data based on the Primary care pediatrics Learning Activity Nutrition (PLAN) study, a clinical trial assessing a diet and exercise intervention for overweight children, that was affected by the COVID-19 pandemic. We show how all of the methods proposed lead to an increase in precision relative to use of complete case data only.

Vertebral labelling and segmentation are two fundamental tasks in an automated spine processing pipeline. Reliable and accurate processing of spine images is expected to benefit clinical decision-support systems for diagnosis, surgery planning, and population-based analysis on spine and bone health. However, designing automated algorithms for spine processing is challenging predominantly due to considerable variations in anatomy and acquisition protocols and due to a severe shortage of publicly available data. Addressing these limitations, the Large Scale Vertebrae Segmentation Challenge (VerSe) was organised in conjunction with the International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI) in 2019 and 2020, with a call for algorithms towards labelling and segmentation of vertebrae. Two datasets containing a total of 374 multi-detector CT scans from 355 patients were prepared and 4505 vertebrae have individually been annotated at voxel-level by a human-machine hybrid algorithm (https://osf.io/nqjyw/, https://osf.io/t98fz/). A total of 25 algorithms were benchmarked on these datasets. In this work, we present the the results of this evaluation and further investigate the performance-variation at vertebra-level, scan-level, and at different fields-of-view. We also evaluate the generalisability of the approaches to an implicit domain shift in data by evaluating the top performing algorithms of one challenge iteration on data from the other iteration. The principal takeaway from VerSe: the performance of an algorithm in labelling and segmenting a spine scan hinges on its ability to correctly identify vertebrae in cases of rare anatomical variations. The content and code concerning VerSe can be accessed at: https://github.com/anjany/verse.

We introduce Gemma 4, a new generation of open-weight, natively multimodal language models in the Gemma model family. Designed to advance compute efficiency and reasoning, the Gemma 4 model suite features dense and Mixture-of-Experts architectures, ranging from 2.3B to 31B parameters. Alongside improved vision and audio encoders for all model sizes, we propose a unified, encoder-free architecture for our 12B model, which ingests raw audio and image patches. Furthermore, we integrate a thinking mode, enabling Gemma models to generate reasoning traces prior to responding. We improve inference speed, memory, and compute efficiency, as well as long-context abilities through critical design choices. Gemma 4 establishes a leap in performance across STEM, multimodal, and long-context benchmarks, and rivals larger, frontier open models in human-rated tasks.

An amplitude analysis of B^-rightarrow D^- D^0 K_S^0 decays is performed using proton-proton collision data, corresponding to an integrated luminosity of 9,fb^{-1}, collected with the LHCb detector at center-of-mass energies of 7, 8, and 13,Tekern -0.1em V. A resonant structure of spin-parity 0^+ is observed in the D^0 K_S^0 invariant-mass spectrum with a significance of 5.3,sigma. The mass and width of the state, modeled with a Breit-Wigner lineshape, are determined to be 2883pm11pm6,Mekern -0.1em V!/c^2 and 87_{-47}^{+22}pm6,Mekern -0.1em V respectively, where the first uncertainties are statistical and the second systematic. These properties and the quark content are consistent with those of the open-charm tetraquark state T_{cs 0}^{*}(2870)^0 observed previously in the D^+ K^- final state of the B^-rightarrow D^- D^+ K^- decay. This result confirms the existence of the T_{cs 0}^{*}(2870)^0 state in a new decay mode. The T_{cs1}^{*}(2900)^0 state, reported in the B^-rightarrow D^- D^+ K^- decay, is also searched for in the D^0 K_S^0 invariant-mass spectrum of the B^- rightarrow D^- D^0 K_S^0 decay, without finding evidence for it.

Prior to the deep learning era, shape was commonly used to describe the objects. Nowadays, state-of-the-art (SOTA) algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from numerous shape-related publications in premier vision conferences as well as the growing popularity of ShapeNet (about 51,300 models) and Princeton ModelNet (127,915 models). For the medical domain, we present a large collection of anatomical shapes (e.g., bones, organs, vessels) and 3D models of surgical instrument, called MedShapeNet, created to facilitate the translation of data-driven vision algorithms to medical applications and to adapt SOTA vision algorithms to medical problems. As a unique feature, we directly model the majority of shapes on the imaging data of real patients. As of today, MedShapeNet includes 23 dataset with more than 100,000 shapes that are paired with annotations (ground truth). Our data is freely accessible via a web interface and a Python application programming interface (API) and can be used for discriminative, reconstructive, and variational benchmarks as well as various applications in virtual, augmented, or mixed reality, and 3D printing. Exemplary, we present use cases in the fields of classification of brain tumors, facial and skull reconstructions, multi-class anatomy completion, education, and 3D printing. In future, we will extend the data and improve the interfaces. The project pages are: https://medshapenet.ikim.nrw/ and https://github.com/Jianningli/medshapenet-feedback

Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic core, active and non-enhancing core. This intrinsic heterogeneity is also portrayed in their radio-phenotype, as their sub-regions are depicted by varying intensity profiles disseminated across multi-parametric magnetic resonance imaging (mpMRI) scans, reflecting varying biological properties. Their heterogeneous shape, extent, and location are some of the factors that make these tumors difficult to resect, and in some cases inoperable. The amount of resected tumor is a factor also considered in longitudinal scans, when evaluating the apparent tumor for potential diagnosis of progression. Furthermore, there is mounting evidence that accurate segmentation of the various tumor sub-regions can offer the basis for quantitative image analysis towards prediction of patient overall survival. This study assesses the state-of-the-art machine learning (ML) methods used for brain tumor image analysis in mpMRI scans, during the last seven instances of the International Brain Tumor Segmentation (BraTS) challenge, i.e., 2012-2018. Specifically, we focus on i) evaluating segmentations of the various glioma sub-regions in pre-operative mpMRI scans, ii) assessing potential tumor progression by virtue of longitudinal growth of tumor sub-regions, beyond use of the RECIST/RANO criteria, and iii) predicting the overall survival from pre-operative mpMRI scans of patients that underwent gross total resection. Finally, we investigate the challenge of identifying the best ML algorithms for each of these tasks, considering that apart from being diverse on each instance of the challenge, the multi-institutional mpMRI BraTS dataset has also been a continuously evolving/growing dataset.