Daily Papers

Codes of professional ethics guide and restrict specialists, who increasingly work with assistants built on large language models. Such an assistant can breach the user's code, or help the user breach it, without the user noticing. Evaluations reporting broad categories of harm cannot show how often this happens or which provision is breached. TenetBench pairs 3,433 requests conflicting with clauses of fifteen Russian-language professional codes with benign twins that differ only in the legitimacy of what is asked. An automated pipeline generates the tasks from the text of a code, so the corpus grows with every code added and a provision yields new tasks on every run. It also produced tasks and human-validated verdicts from two English codes of other jurisdictions. In human validation of the frozen pipeline, specialists rated 0.995 of the conflicting tasks plausible, and the model judge agreed with the adjudicated label at Gwet's AC1 of at least 0.894 on 1,860 elements. We evaluated fourteen model and reasoning-mode combinations on whether they produce the conflicting text, decline or warn. Eleven of the fourteen produce conflicting content on most such requests, mostly without a warning, and nearly three warnings in four accompany conflicting content. The models that conform more do so by declining while still serving the legitimate twin, and enabling reasoning halved the refusals of two models. We hope the dataset and pipeline will help evaluate how language models observe professional norms and let diagnostic datasets be built for particular professions and organisations.

A digital twin is a virtual replica of a real-world physical phenomena that uses mathematical modeling to characterize and simulate its defining features. By constructing digital twins for disease processes, we can perform in-silico simulations that mimic patients' health conditions and counterfactual outcomes under hypothetical interventions in a virtual setting. This eliminates the need for invasive procedures or uncertain treatment decisions. In this paper, we propose a method to identify digital twin model parameters using only noninvasive patient health data. We approach the digital twin modeling as a composite inverse problem, and observe that its structure resembles pretraining and finetuning in self-supervised learning (SSL). Leveraging this, we introduce a physics-informed SSL algorithm that initially pretrains a neural network on the pretext task of solving the physical model equations. Subsequently, the model is trained to reconstruct low-dimensional health measurements from noninvasive modalities while being constrained by the physical equations learned in pretraining. We apply our method to identify digital twins of cardiac hemodynamics using noninvasive echocardiogram videos, and demonstrate its utility in unsupervised disease detection and in-silico clinical trials.

Digital twin technology has is anticipated to transform healthcare, enabling personalized medicines and support, earlier diagnoses, simulated treatment outcomes, and optimized surgical plans. Digital twins are readily gaining traction in industries like manufacturing, supply chain logistics, and civil infrastructure. Not in patient care, however. The challenge of modeling complex diseases with multimodal patient data and the computational complexities of analyzing it have stifled digital twin adoption in the biomedical vertical. Yet, these major obstacles can potentially be handled by approaching these models in a different way. This paper proposes a novel framework for addressing the barriers to clinical twin modeling created by computational costs and modeling complexities. We propose structuring patient health data as a knowledge graph and using closed-form continuous-time liquid neural networks, for real-time analytics. By synthesizing multimodal patient data and leveraging the flexibility and efficiency of closed form continuous time networks and knowledge graph ontologies, our approach enables real time insights, personalized medicine, early diagnosis and intervention, and optimal surgical planning. This novel approach provides a comprehensive and adaptable view of patient health along with real-time analytics, paving the way for digital twin simulations and other anticipated benefits in healthcare.

Deceptive web content, widely instantiated across the internet and commonly known as social-engineering attacks, manipulates autonomous web agents into submitting users' personally identifiable information (PII) to attacker-controlled endpoints. In this paper, we show that social-engineering attacks are highly effective at extracting critical-tier PII from frontier web agents, posing a severe risk to deployed agentic systems. To quantify this risk, we introduce \textsc{Scammer4U}, a pre-registered benchmark of 91 attacker-controlled environments and 10 benign-twin baselines, spanning 8 attack vectors and 16 site categories on an 8-axis factorial taxonomy that isolates the causal contribution of individual attack design factors. Across frontier agents, we find that critical-tier PII leakage reaches 54--93\% under no privacy guidance, compared to 0\% on benign-twin baselines, confirming that leakage is attack-attributable rather than incidental form-filling. Escalating prompt-level mitigation yields sharply model-dependent reductions across the four families and remains insufficient to reliably prevent critical PII submission at the pooled level. Most critically, we identify a detection--action gap: agents whose reasoning an independent LLM judge confirms has flagged the site as suspicious still submit critical PII in 35.9\% of sessions, versus 66.1\% when no suspicion is verbalized, a 30.2\% gap robust across all four model families. Our findings reveal that defenses conditioned on the agent's own recognition of an attack are gating on the wrong signal, motivating output-level interception of outbound submissions that operates independently of the agent's reasoning loop.

After being collected for patient care, Observational Health Data (OHD) can further benefit patient well-being by sustaining the development of health informatics and medical research. Vast potential is unexploited because of the fiercely private nature of patient-related data and regulations to protect it. Generative Adversarial Networks (GANs) have recently emerged as a groundbreaking way to learn generative models that produce realistic synthetic data. They have revolutionized practices in multiple domains such as self-driving cars, fraud detection, digital twin simulations in industrial sectors, and medical imaging. The digital twin concept could readily apply to modelling and quantifying disease progression. In addition, GANs posses many capabilities relevant to common problems in healthcare: lack of data, class imbalance, rare diseases, and preserving privacy. Unlocking open access to privacy-preserving OHD could be transformative for scientific research. In the midst of COVID-19, the healthcare system is facing unprecedented challenges, many of which of are data related for the reasons stated above. Considering these facts, publications concerning GAN applied to OHD seemed to be severely lacking. To uncover the reasons for this slow adoption, we broadly reviewed the published literature on the subject. Our findings show that the properties of OHD were initially challenging for the existing GAN algorithms (unlike medical imaging, for which state-of-the-art model were directly transferable) and the evaluation synthetic data lacked clear metrics. We find more publications on the subject than expected, starting slowly in 2017, and since then at an increasing rate. The difficulties of OHD remain, and we discuss issues relating to evaluation, consistency, benchmarking, data modelling, and reproducibility.