Daily Papers

Automated classification of standard echocardiographic views is crucial for efficient clinical workflow but faces three main challenges. First, publicly available datasets are scarce and limited in scale and view coverage. Second, the performance of some modern video-level architectures for echocardiographic view classification remains underexplored. Third, some view categories exhibit highly similar spatial appearances, making single-frame features insufficient for discrimination, while heterogeneous frame quality complicates robust temporal information fusion. To address these challenges, we release the Echocardiographic Videos of Nine Views (EV9V) dataset, comprising 5,138 videos, 910,579 frames, and 9 standard views, which is, to the best of our knowledge, the largest publicly available echocardiography video dataset. Using EV9V, we systematically benchmark representative video classification architectures, including Convolutional Neural Networks (CNNs), Recurrent Neural Networks (RNNs), and Transformers. Furthermore, we propose a Spatio-Temporal Fusion Model (STFM), an efficient dual-stream CNN-LSTM (Long Short-Term Memory) framework that jointly captures spatial anatomical structures and temporal cardiac dynamics. The proposed framework leverages uncertainty-aware learning to preferentially sample representative video segments during training and evidence-based fusion during inference, improving robustness to variations in frame quality across echocardiographic videos. Extensive experiments demonstrate that our method achieves competitive performance across diverse video classification models, validating the effectiveness of uncertainty-aware spatio-temporal learning for echocardiographic view classification. The code is available at https://github.com/bgx666/stfm.

Many machine learning systems have access to multiple sources of evidence for the same prediction target, yet these sources often differ in reliability and informativeness across inputs. In bioacoustic classification, species identity may be inferred both from the acoustic signal and from spatiotemporal context such as location and season; while Bayesian inference motivates multiplicative evidence combination, in practice we typically only have access to discriminative predictors rather than calibrated generative models. We introduce Fusion under INdependent Conditional Hypotheses (FINCH), an adaptive log-linear evidence fusion framework that integrates a pre-trained audio classifier with a structured spatiotemporal predictor. FINCH learns a per-sample gating function that estimates the reliability of contextual information from uncertainty and informativeness statistics. The resulting fusion family contains the audio-only classifier as a special case and explicitly bounds the influence of contextual evidence, yielding a risk-contained hypothesis class with an interpretable audio-only fallback. Across benchmarks, FINCH consistently outperforms fixed-weight fusion and audio-only baselines, improving robustness and error trade-offs even when contextual information is weak in isolation. We achieve state-of-the-art performance on CBI and competitive or improved performance on several subsets of BirdSet using a lightweight, interpretable, evidence-based approach. Code is available: \href{https://anonymous.4open.science/r/birdnoise-85CD/README.md{anonymous-repository}}

Accurate classification of computed tomography (CT) images is essential for diagnosis and treatment planning, but existing methods often struggle with the subtle and spatially diverse nature of pathological features. Current approaches typically process images uniformly, limiting their ability to detect localized abnormalities that require focused analysis. We introduce UGPL, an uncertainty-guided progressive learning framework that performs a global-to-local analysis by first identifying regions of diagnostic ambiguity and then conducting detailed examination of these critical areas. Our approach employs evidential deep learning to quantify predictive uncertainty, guiding the extraction of informative patches through a non-maximum suppression mechanism that maintains spatial diversity. This progressive refinement strategy, combined with an adaptive fusion mechanism, enables UGPL to integrate both contextual information and fine-grained details. Experiments across three CT datasets demonstrate that UGPL consistently outperforms state-of-the-art methods, achieving improvements of 3.29%, 2.46%, and 8.08% in accuracy for kidney abnormality, lung cancer, and COVID-19 detection, respectively. Our analysis shows that the uncertainty-guided component provides substantial benefits, with performance dramatically increasing when the full progressive learning pipeline is implemented. Our code is available at: https://github.com/shravan-18/UGPL

In practical scenarios, time series forecasting necessitates not only accuracy but also efficiency. Consequently, the exploration of model architectures remains a perennially trending topic in research. To address these challenges, we propose a novel backbone architecture named Time Evidence Fusion Network (TEFN) from the perspective of information fusion. Specifically, we introduce the Basic Probability Assignment (BPA) Module based on evidence theory to capture the uncertainty of multivariate time series data from both channel and time dimensions. Additionally, we develop a novel multi-source information fusion method to effectively integrate the two distinct dimensions from BPA output, leading to improved forecasting accuracy. Lastly, we conduct extensive experiments to demonstrate that TEFN achieves performance comparable to state-of-the-art methods while maintaining significantly lower complexity and reduced training time. Also, our experiments show that TEFN exhibits high robustness, with minimal error fluctuations during hyperparameter selection. Furthermore, due to the fact that BPA is derived from fuzzy theory, TEFN offers a high degree of interpretability. Therefore, the proposed TEFN balances accuracy, efficiency, stability, and interpretability, making it a desirable solution for time series forecasting.

Synthesizing photorealistic driving videos along specified trajectories is essential for scalable closed-loop simulation. Reconstruction-based methods leverage neural rendering to synthesize geometrically consistent views, but often exhibit diverse artifacts and missing content when the viewpoint deviates from the training trajectory. In contrast, generative models can synthesize realistic views along arbitrary trajectories from vehicle sensor data, yet often struggle to maintain temporal and geometric consistency across frames. To combine the strengths of both, we propose PRG-Fusion, a framework for driving view synthesis that uses reconstruction evidence to orchestrate generative priors across regions. Specifically, we extract region-wise degradation evidence from reconstructed driving scenes and convert it into Preserve, Repair, and Generate (PRG) labels. At inference, these labels serve as a unified routing policy for region-aware spatiotemporal synthesis, orchestrating 3DGS appearance preservation, LiDAR-guided structural correction, and video-prior-driven content completion across Preserve, Repair, and Generate regions, respectively. We then follow a two-stage training paradigm, first establish geometric control from sparse LiDAR projections and subsequently learning appearance control from dense 3DGS renderings. Extensive experiments on Waymo demonstrate that PRG-Fusion achieves state-of-the-art overall performance in novel trajectory video synthesis, with superior visual quality and geometric fidelity while maintaining competitive view consistency under large trajectory shifts.

Large language models (LLMs) fine-tuned on multimodal financial data have demonstrated impressive reasoning capabilities in various financial tasks. However, they often struggle with multi-step, goal-oriented scenarios in interactive financial markets, such as trading, where complex agentic approaches are required to improve decision-making. To address this, we propose FLAG-Trader, a unified architecture integrating linguistic processing (via LLMs) with gradient-driven reinforcement learning (RL) policy optimization, in which a partially fine-tuned LLM acts as the policy network, leveraging pre-trained knowledge while adapting to the financial domain through parameter-efficient fine-tuning. Through policy gradient optimization driven by trading rewards, our framework not only enhances LLM performance in trading but also improves results on other financial-domain tasks. We present extensive empirical evidence to validate these enhancements.

Multimodal AI models are increasingly used in fields like healthcare, finance, and autonomous driving, where information is drawn from multiple sources or modalities such as images, texts, audios, videos. However, effectively managing uncertainty - arising from noise, insufficient evidence, or conflicts between modalities - is crucial for reliable decision-making. Current uncertainty-aware machine learning methods leveraging, for example, evidence averaging, or evidence accumulation underestimate uncertainties in high-conflict scenarios. Moreover, the state-of-the-art evidence averaging strategy is not order invariant and fails to scale to multiple modalities. To address these challenges, we propose a novel multimodal learning method with order-invariant evidence fusion and introduce a conflict-based discounting mechanism that reallocates uncertain mass when unreliable modalities are detected. We provide both theoretical analysis and experimental validation, demonstrating that unlike the previous work, the proposed approach effectively distinguishes between conflicting and non-conflicting samples based on the provided uncertainty estimates, and outperforms the previous models in uncertainty-based conflict detection.

Discovering novel high-entropy alloys (HEAs) with desirable properties is challenging due to the vast compositional space and complex phase formation mechanisms. Efficient exploration of this space requires a strategic approach that integrates heterogeneous knowledge sources. Here, we propose a framework that systematically combines knowledge extracted from computational material datasets with domain knowledge distilled from scientific literature using large language models (LLMs). A central feature of this approach is the explicit consideration of element substitutability, identifying chemically similar elements that can be interchanged to potentially stabilize desired HEAs. Dempster-Shafer theory, a mathematical framework for reasoning under uncertainty, is employed to model and combine substitutabilities based on aggregated evidence from multiple sources. The framework predicts the phase stability of candidate HEA compositions and is systematically evaluated on both quaternary alloy systems, demonstrating superior performance compared to baseline machine learning models and methods reliant on single-source evidence in cross-validation experiments. By leveraging multi-source knowledge, the framework retains robust predictive power even when key elements are absent from the training data, underscoring its potential for knowledge transfer and extrapolation. Furthermore, the enhanced interpretability of the methodology offers insights into the fundamental factors governing HEA formation. Overall, this work provides a promising strategy for accelerating HEA discovery by integrating computational and textual knowledge sources, enabling efficient exploration of vast compositional spaces with improved generalization and interpretability.

The proliferation of sophisticated image editing tools and generative artificial intelligence models has made verifying the authenticity of digital images increasingly challenging, with important implications for journalism, forensic analysis, and public trust. Although numerous forensic algorithms, ranging from handcrafted methods to deep learning-based detectors, have been developed for manipulation detection, individual methods often suffer from limited robustness, fragmented evidence, or weak generalization across manipulation types and image conditions. To address these limitations, we present FRAME, a method for Forensic Routing and Adaptive Multi-path Evidence fusion for image manipulation detection. FRAME organizes diverse forensic algorithms into a multi-path analysis space, adaptively selects informative forensic paths for each input image, and fuses complementary evidence to improve detection and localization performance. By moving beyond single-method analysis and fixed fusion strategies, FRAME provides a more robust and flexible approach to image forensic reasoning while preserving interpretable forensic cues from multiple evidence sources. Experimental results demonstrate the effectiveness of FRAME across diverse manipulation scenarios. Code is available at https://github.com/kzhao5/FRAME{https://github.com/kzhao5/FRAME}.

Unmanned Aerial Vehicle (UAV) threats have emerged as a defining security challenge of the 21st century. This paper presents DroneShield-AI, a unified open framework integrating six processing layers: RF signal classification, acoustic motor-signature detection, YOLOv8-based visual detection, evidence-weighted sensor fusion, a Behavioral Intent Classification Engine (BICE), and a Graph Neural Network Swarm Intelligence Module (GNN-SIM). BICE introduces the first systematic six-class threat taxonomy for drone flight patterns, enabling predictive operator alerts with a 30-second advance-warning horizon. GNN-SIM is the first open framework for adversarial multi-drone formation analysis using Graph Attention Networks. Evaluated on three publicly available real-world datasets, the fused pipeline achieves 96.1% detection accuracy, 3.2% false alarm rate, AUC-ROC: 0.981, and 142ms end-to-end latency on commodity CPU-class hardware at approximately 500-780 USD total system cost. All code, model weights, and simulation datasets are publicly released at submission.

Scientific figure assessment in peer review differs fundamentally from general image quality evaluation: a figure must be visually legible, faithfully support the manuscript's claims, and communicate evidence with a clear visual hierarchy. However, if we apply traditional image assessment methods to scientific figure quality assessment, limitations emerge: classic IQA models capture perceptual quality or aesthetics but cannot judge whether a figure serves the paper's scientific argument; CLIP-based methods assess generic image-text correspondence, yet lack understanding of manuscript context; and zero-shot LLM/VLM judges, when repurposed for figure scoring, often yield overly concentrated scores with limited fusion of visual and textual evidence. We introduce an annotated dataset of 3,857 scientific figures from peer-reviewed conference papers, each rated along four peer-review-oriented dimensions: Clarity, Relevance, Informativeness, and Structure. We propose SciFigAlign, a fine-tuned multimodal scorer that grounds figure quality assessment in manuscript evidence. Given a figure crop, caption, citing paragraphs, and light paper context, SciFigAlign fine-tunes CLIP and SciBERT end-to-end with per-modality cross-attention and CubeMLP fusion, jointly optimizing SmoothL1 regression with a within-paper ranking hinge loss. Under paper-level splits, SciFigAlign achieves a macro MAE of 0.3524 and a within-paper pairwise accuracy of 81.64% on the test set with n = 396, a 59% relative error reduction over the best LLM-as-judge baseline with MAE 0.864. Ablations confirm that manuscript-grounded inputs, citing-context denoising, and ranking supervision are all critical, showing that scientific figure assessment requires learned alignment between visual content and manuscript evidence rather than prompting alone, even with state-of-the-art VLMs.

High-quality 3D scene assets are critical for embodied applications such as robotic manipulation, navigation, and simulation. Despite their strong object priors, recent single-image 3D generation models such as SAM3D remain insufficient for real-world scenes, where severe occlusions, redundant observations, and cross-view inconsistencies make reliable scene generation challenging. We introduce Scene-SAM3D, a training-free framework that extends SAM3D from single-view object generation to calibrated multi-view scene asset generation. Scene-SAM3D selects a compact set of complementary views, reducing observation redundancy while providing additional evidence for regions occluded in individual views. Based on the selected views, it performs step-efficient latent velocity fusion to integrate multi-view evidence and suppress cross-view conflicts in canonical space. Finally, a lightweight rigid-object Gaussian optimization refines the scene layout within 200 iterations while preserving the generated object geometry. Experiments on Replica and ScanNet++ demonstrate consistent improvements at both instance and scene levels, with our method reducing scene-level CD by 43.8% on Replica and 30.9% on ScanNet++, while cutting flow-model sampling FLOPs and wall-time latency by nearly 20% under the same multi-view setting. Code will be released at https://github.com/xibi777/Scene-SAM3D.

We present the AILS-NTUA system for SemEval-2026 Task 8 (MTRAGEval), addressing all three subtasks of multi-turn retrieval-augmented generation: passage retrieval (A), reference-grounded response generation (B), and end-to-end RAG (C). Our unified architecture is built on two principles: (i) a query-diversity-over-retriever-diversity strategy, where five complementary LLM-based query reformulations are issued to a single corpus-aligned sparse retriever and fused via variance-aware nested Reciprocal Rank Fusion; and (ii) a multistage generation pipeline that decomposes grounded generation into evidence span extraction, dual-candidate drafting, and calibrated multi-judge selection. Our system ranks 1st in Task A (nDCG@5: 0.5776, +20.5% over the strongest baseline) and 2nd in Task B (HM: 0.7698). Empirical analysis shows that query diversity over a well-aligned retriever outperforms heterogeneous retriever ensembling, and that answerability calibration-rather than retrieval coverage-is the primary bottleneck in end-to-end performance.

Multimodal humor in memes, cartoons, and comics remains difficult for AI systems because intended meaning depends on non-literal mechanisms, shared cultural knowledge, and communicative intent rather than literal scene description. This survey focuses on visual humor understanding in single-image and multi-panel artifacts, while treating humor generation as an emerging downstream frontier. We position the literature against prior humor, sarcasm, and general MLLM surveys and organize it using a capability-centric hierarchy spanning recognition, interpretation and reasoning, and generation. Under this lens, we synthesize benchmark design, evaluation protocols, and modeling paradigms, tracing the field's shift from task-specific fusion models to large-model approaches based on multimodal alignment, evidence-grounded reasoning, and controlled generation. We conclude by highlighting the main barriers to progress: shortcut-prone evaluation, limited cultural and narrative coverage, weak evidence grounding, and unresolved safety and ownership concerns.

Ontology rankers remain useful for rare-disease diagnosis because each candidate can be traced to matched patient phenotypes. Large language models (LLMs) can generate differential diagnoses from the same patient description, but their predictions lack an equally clear evidence trail. Rather than asking which system should replace the other, we ask whether an LLM can improve the ranker without giving up its evidence. Our behavior-based fusion model examines the two ranked lists, their agreement, and the ontology support behind each candidate, and learns how much to rely on each system for the individual case. Before comparison, we remove a documented test-set leakage pathway caused by benchmark cases and ontology annotations being derived from the same publications. Across eight open LLMs, fusion improves Phenomizer Recall@1 by 7.86 percentage points on Phenopacket Store and 20.18 points on RAMEDIS. When paired with DeepSeek-V4-Flash through an API, a fusion model trained only on the other LLMs improves Recall@1 from 0.1657 to 0.2176, a 5.19-point gain, without retraining. For 90.8% of correct fused diagnoses, the disease retains candidate-level ontology evidence that can be inspected. These results show that LLMs can strengthen an established diagnostic tool without discarding the structured evidence that makes it useful.

Long video understanding remains challenging due to its complex, diverse, and temporally scattered content. Although video large language models (Video-LLMs) can process videos lasting tens of minutes, applying them to truly long sequences is computationally prohibitive and often leads to unfocused or inconsistent reasoning. A promising solution is to select only the most informative frames, yet existing approaches typically ignore temporal dependencies or rely on unimodal evidence, limiting their ability to provide complete and query-relevant context. We propose a Semantic-Visual Consensus Evidence Selection (SeViCES) framework for effective and reliable long video understanding. SeViCES is training-free and model-agnostic, and introduces two key components. The Semantic-Visual Consensus Frame Selection (SVCFS) module selects frames through (1) a temporal-aware semantic branch that leverages LLM reasoning over captions, and (2) a cluster-guided visual branch that aligns embeddings with semantic scores via mutual information. The Answer Consensus Refinement (ACR) module further resolves inconsistencies between semantic- and visual-based predictions by fusing evidence and constraining the answer space. Extensive experiments on long video understanding benchmarks show that SeViCES consistently outperforms state-of-the-art methods in both accuracy and robustness, demonstrating the importance of consensus-driven evidence selection for Video-LLMs.

Cervical cytology presents a fundamentally ambiguous diagnostic landscape, where equivocal categories such as Atypical Squamous Cells of Undetermined Significance (ASC-US) occupy a morphological grey zone that is definitional. For clinical decision support, the goal extends beyond assigning a definitive label to every sample: cases must also be distinguished by whether the available evidence supports a confident decision or warrants further consideration, a distinction conventional classification models are not designed to explicitly represent. We propose a multiscale evidential framework that models cervical cytology along an ordinal disease continuum using clinically grounded soft anchors, representing progression from benign reactive changes to precancerous lesions and malignancy. Three biologically motivated spatial contexts--nuclear morphology, cytoplasmic characteristics, and neighbourhood cellular architecture--are independently encoded using a shared frozen DINOv2 backbone, preserving inter-scale disagreement that early fusion may obscure. Calibrated predictions are transformed into Dempster--Shafer belief masses and fused with reliability discounting, allowing conflicting evidence and insufficient support to remain explicitly uncommitted rather than forcing a decision. The fused belief state drives interpretable routing that separates confidently classified cases from those with irreducible evidential insufficiency, enabling clinically meaningful triage. Across two independent publicly available conventional cytology datasets, RIVA and CRIC Cervix, the framework generalises consistently, with uncertainty strongly associated with diagnostic difficulty: incorrect predictions carry 1.94x-4.13x higher uncertainty than correct ones.

Statistical data fusion combines two panels that share a block of covariates but observe disjoint outcome blocks, and in its traditional form no row observes both outcomes at once. That rules out the discriminative criterion one would rather train a Deep Boltzmann Machine with, since multi-prediction training needs ground truth for whatever it holds out. We propose observed-block multi-prediction, which restricts the multi-prediction objective to targets drawn from what each row actually observes. It is well defined for any missingness pattern and reduces to the original criterion when rows are complete. Having a discriminative criterion that survives the setting lets us ask whether the joint model is needed at all, by separating what it contributes into a representation part and an inference part. On two consumer panels, on grids over sample size and covariate width spanning 35 cells and 875 runs, the fine-tuned DBM is the best of fifteen methods in every cell; but almost none of that advantage comes from generative pre-training, which is confined to the smallest sample size on one dataset and absent on the other. It comes from conditioning on one outcome block when predicting the other. This term amounts to +0.19 and +0.07 percentage points, is positive in all 35 cells, and, unlike every other contribution we measure, neither decays as the panels grow, nor requires a second hidden layer, nor requires more inference. Permuting one outcome block to destroy its association with the other removes the gain entirely, which is what the account predicts. The margins are small. But a small effect that does not decay is a different object from one that does, because it rests on evidence that no model mapping covariates to outcomes can accept.

We present OctWorld, a video diffusion framework with persistent 3D memory for generating explorable, world-consistent, and high-fidelity visual scenes. Given a single image, OctWorld performs stable autoregressive world generation along user-specified camera trajectories. We focus on long-range generation, characterized by extended camera paths and wide viewpoint coverage, where preserving spatial consistency is particularly challenging when previously generated regions are revisited. To address this problem, we introduce OctMap, an extensible and spatially adaptive 3D memory that progressively fuses generated visual observations and their corresponding depth maps into a global representation. OctMap employs TSDF fusion within a dynamic sparse octree whose spatial resolution adapts to image evidence. This design preserves geometric and appearance details across diverse scene scales while maintaining low memory overhead. Experiments demonstrate that OctWorld generates long-range, spatially consistent videos and outperforms prior methods on both existing benchmarks and challenging long-range generation settings. OctMap also provides clear advantages over point-based caches and fixed-resolution TSDF volumes. Project page: https://maxtirerror.github.io/octworldpage/

Large Audio Language Models (LALMs) still struggle in complex acoustic scenes because they often fail to preserve task-relevant acoustic evidence before reasoning begins. We call this failure the evidence bottleneck: state-of-the-art systems show larger deficits in evidence extraction than in downstream reasoning, suggesting that the main limitation lies in upstream perception rather than reasoning policy. To address this problem, we propose EvA (Evidence-First Audio), a dual-path architecture that combines Whisper and CED-Base through non-compressive, time-aligned fusion. EvA first aggregates intermediate CED layers to preserve multi-scale acoustic cues, then aligns the aggregated CED features to the Whisper timeline and adds the two streams without changing sequence length. We also build EvA-Perception, a large-scale open-source training set with about 54K event-ordered captions (150 h) and about 500K QA pairs. Under a unified zero-shot protocol, EvA achieves the best open-source Perception scores on MMAU, MMAR, and MMSU, and improves over Kimi-Audio-7B on all reported metrics, with the largest gains on perception-heavy splits. These results support the evidence-first hypothesis: stronger audio understanding depends on preserving acoustic evidence before reasoning.

BoN improves model outputs by sampling several candidates and selecting one with a proxy score, but it assumes that complete candidates can be evaluated reliably. Many vision-language tasks instead provide only partial verification: a finding, span, value, region, or relation may be checkable even when no dependable whole-response verifier exists. Moreover, the same claim may recur across candidates with opposing stances, allowing one observation to support part of the pool and contradict another. We introduce Best-of-Evidence (BoE), an inference-time selection framework that keeps the BoN candidate pool fixed, represents reusable claims with a signed candidate--factor graph, and allocates a limited budget to evidence actions that can change the final choice. BoE formalizes selection under partial verification and provides a practical score-based controller, with the zero-budget case recovering the underlying BoN decision. Theoretically, we show that residual evidence capacity limits any evidence-driven improvement and that shared factor queries can achieve an O(log K) versus Θ(K) query separation in a factor-code model. Common-ledger experiments on four medical VQA settings show that BoE can improve fixed-pool selection and rescue some BoN failures when evidence is reliable, contrastive, and decision-relevant, while also revealing the channel-quality and candidate-generation limits that prevent universal gains.

Scientific research based on multimodal clinical data (including medical imaging) requires coordinating clinical, radiological, programming, and biostatistical expertise, a fragmented process that bottlenecks discovery. We present VERITAS (Verifiable Epistemic Reasoning for Image-Derived Hypothesis Testing via Agentic Systems), a clinical co-scientist: a multi-agent system that autonomously tests natural-language hypotheses and produces a fully auditable evidence trail, tracing every conclusion through executable outputs from analysis plan to segmentation masks to statistical code to final verdict. Unlike prior AI-scientist systems, which mainly operate on tabular or text data, VERITAS grounds autonomous discovery directly in medical images. It decomposes the workflow into four phases handled by role-specialized agents, and introduces an epistemic evidence label framework that mechanically classifies outcomes as Supported, Refuted, Underpowered, or Invalid by jointly evaluating significance, effect direction, and study power. This distinction is critical in medical imaging, where non-significant results often reflect insufficient sample size rather than absent effects. We construct a tiered benchmark of 64 hypotheses spanning six complexity levels across cardiac and brain glioma MRI datasets. VERITAS reaches 81.4% verdict accuracy with frontier models and 71.2% with locally-hosted open-weight models (8-30B), outperforming all single-model baselines in both classes. It also produces the highest rate of independently verifiable statistical outputs (86.6%), so even its failures remain diagnosable through artifact inspection. Structured multi-agent decomposition thus substitutes for model scale while preserving the verifiability that scientific discovery demands. We release code, hypothesis bank, and evaluation pipeline at https://github.com/LucZot/veritas.

Training AI models that generalize across tasks and domains has long been among the open problems driving AI research. The emergence of Foundation Models made it easier to obtain expert models for a given task, but the heterogeneity of data that may be encountered at test time often means that any single expert is insufficient. We consider the Fusion of Experts (FoE) problem of fusing outputs of expert models with complementary knowledge of the data distribution and formulate it as an instance of supervised learning. Our method is applicable to both discriminative and generative tasks and leads to significant performance improvements in image and text classification, text summarization, multiple-choice QA, and automatic evaluation of generated text. We also extend our method to the "frugal" setting where it is desired to reduce the number of expert model evaluations at test time.

Medical imaging is critical for diagnostics, but clinical adoption of advanced AI-driven imaging faces challenges due to patient variability, image artifacts, and limited model generalization. While deep learning has transformed image analysis, 3D medical imaging still suffers from data scarcity and inconsistencies due to acquisition protocols, scanner differences, and patient motion. Traditional augmentation uses a single pipeline for all transformations, disregarding the unique traits of each augmentation and struggling with large data volumes. To address these challenges, we propose a Multi-encoder Augmentation-Aware Learning (MEAL) framework that leverages four distinct augmentation variants processed through dedicated encoders. Three fusion strategies such as concatenation (CC), fusion layer (FL), and adaptive controller block (BD) are integrated to build multi-encoder models that combine augmentation-specific features before decoding. MEAL-BD uniquely preserves augmentation-aware representations, enabling robust, protocol-invariant feature learning. As demonstrated in a Computed Tomography (CT)-to-T1-weighted Magnetic Resonance Imaging (MRI) translation study, MEAL-BD consistently achieved the best performance on both unseen- and predefined-test data. On both geometric transformations (like rotations and flips) and non-augmented inputs, MEAL-BD outperformed other competing methods, achieving higher mean peak signal-to-noise ratio (PSNR) and structural similarity index measure (SSIM) scores. These results establish MEAL as a reliable framework for preserving structural fidelity and generalizing across clinically relevant variability. By reframing augmentation as a source of diverse, generalizable features, MEAL supports robust, protocol-invariant learning, advancing clinically reliable medical imaging solutions.

Recent benchmarks for VLMs largely assess single- or limited-view perception, leaving untested the core cognitive ability to integrate observations across viewpoints into a coherent, world-centric (allocentric) 3D mental model. We introduce MultiView-Bench, a diagnostic benchmark expressly designed to evaluate multi-view integration for holistic 3D scene comprehension. Unlike existing datasets that focus on pixel-level mapping or camera-relative navigation, MultiView-Bench requires models to decouple object positioning from transient perspectives and ground them in a fixed global coordinate system. This capability serves as a prerequisite for VLMs before being deployed for downstream tasks such as mechanical part assembly. Our systematic evaluation of frontier VLMs reveals consistent failure modes: strong performance on 2D planar relations from a single image, but marked difficulty with 3D spatial relations and with aggregating information across views. We further identify biases in VLMs, such as struggles with unconventional axis directions and sensitivity to object colorways and texture variations. Acknowledging these limitations, we propose ViewNavigator, which uses active viewpoint selection and evidence fusion to improve four base models by 12.3--20.0 percentage points under a six-image cap matching the fixed-view baseline; budget-extended gains are model-dependent and reach 27 percentage points for GPT-5.

Scientific research follows multi-turn, multi-step workflows that require proactively searching the literature, consulting figures and tables, and integrating evidence across papers to align experimental settings and support reproducible conclusions. This joint capability is not systematically assessed in existing benchmarks, which largely under-evaluate proactive search, multi-evidence integration and sustained evidence use over time. In this work, we introduce EpiBench, an episodic multi-turn multimodal benchmark that instantiates short research workflows. Given a research task, agents must navigate across papers over multiple turns, align evidence from figures and tables, and use the accumulated evidence in the memory to answer objective questions that require cross paper comparisons and multi-figure integration. EpiBench introduces a process-level evaluation framework for fine-grained testing and diagnosis of research agents. Our experiments show that even the leading model achieves an accuracy of only 29.23% on the hard split, indicating substantial room for improvement in multi-turn, multi-evidence research workflows, providing an evaluation platform for verifiable and reproducible research agents.

Automated radiology report generation holds immense potential to alleviate the heavy workload of radiologists. Despite the formidable vision-language capabilities of recent Multimodal Large Language Models (MLLMs), their clinical deployment is severely constrained by inherent limitations: their "black-box" decision-making renders the generated reports untraceable due to the lack of explicit visual evidence to support the diagnosis, and they struggle to access external domain knowledge. To address these challenges, we propose the Evidence-driven Radiology Report Generation Agent (EviAgent). Unlike opaque end-to-end paradigms, EviAgent coordinates a transparent reasoning trajectory by breaking down the complex generation process into granular operational units. We integrate multi-dimensional visual experts and retrieval mechanisms as external support modules, endowing the system with explicit visual evidence and high-quality clinical priors. Extensive experiments on MIMIC-CXR, CheXpert Plus, and IU-Xray datasets demonstrate that EviAgent outperforms both large-scale generalist models and specialized medical models, providing a robust and trustworthy solution for automated radiology report generation.

Obtaining high-quality generations in modern LLMs has largely been framed as a selection problem: identifying a single winning generation from a diverse pool of N samples, the Best-of-N (BoN). Yet, this approach is inherently zero-sum, discarding diverse and potentially useful information from the pool. Instead, we explore a collaborative setup, where all candidates can potentially contribute to the final winning generation. To this end, we propose Fusion-of-N (FusioN): a method that uses a general LLM judge to synthesize the most informative elements of each sample into a single final answer. We compare FusioN to BoN in two settings, (i) test-time scaling, where we sample and aggregate from a single model at test-time (ii) synthetic data generation, where we fuse samples from a pool of diverse teachers to improve a student model. We extensively benchmark both setups across 11 languages, 3 diverse tasks and varying model scales. Across the bench, FusioN consistently outperforms BoN showing versatility and robustness both in test-time scaling and in downstream gains from synthetic data generation. We also perform extensive analysis on FusioN, where it shows surprising strengths and robustness under challenging settings. These results show that we should shift how we think about evaluating and utilizing LLM generations from a monolithic measure of quality, to embracing their polylithic nature. This shift allows us to integrate diverse strengths, unlock latent potential, and achieve improvements that were previously inaccessible through selection alone.

Multi-modal fusion approaches aim to integrate information from different data sources. Unlike natural datasets, such as in audio-visual applications, where samples consist of "paired" modalities, data in healthcare is often collected asynchronously. Hence, requiring the presence of all modalities for a given sample is not realistic for clinical tasks and significantly limits the size of the dataset during training. In this paper, we propose MedFuse, a conceptually simple yet promising LSTM-based fusion module that can accommodate uni-modal as well as multi-modal input. We evaluate the fusion method and introduce new benchmark results for in-hospital mortality prediction and phenotype classification, using clinical time-series data in the MIMIC-IV dataset and corresponding chest X-ray images in MIMIC-CXR. Compared to more complex multi-modal fusion strategies, MedFuse provides a performance improvement by a large margin on the fully paired test set. It also remains robust across the partially paired test set containing samples with missing chest X-ray images. We release our code for reproducibility and to enable the evaluation of competing models in the future.

Retrieval-augmented generation (RAG) promises grounded question answering, yet domain settings with multiple heterogeneous knowledge bases (KBs) remain challenging. In Chinese Tibetan medicine, encyclopedia entries are often dense and easy to match, which can dominate retrieval even when classics or clinical papers provide more authoritative evidence. We study a practical setting with three KBs (encyclopedia, classics, and clinical papers) and a 500-query benchmark (cutoff K{=}5) covering both single-KB and cross-KB questions. We propose two complementary methods to improve traceability, reduce hallucinations, and enable cross-KB verification. First, DAKS performs KB routing and budgeted retrieval to mitigate density-driven bias and to prioritize authoritative sources when appropriate. Second, we use an alignment graph to guide evidence fusion and coverage-aware packing, improving cross-KB evidence coverage without relying on naive concatenation. All answers are generated by a lightweight generator, openPangu-Embedded-7B. Experiments show consistent gains in routing quality and cross-KB evidence coverage, with the full system achieving the best CrossEv@5 while maintaining strong faithfulness and citation correctness.

We introduce InfiFusion, an efficient training pipeline designed to integrate multiple domain-specialized Large Language Models (LLMs) into a single pivot model, effectively harnessing the strengths of each source model. Traditional fusion methods either merge model parameters directly or rely on knowledge distillation with rigid assumptions, limiting their flexibility and efficiency. InfiFusion overcomes these limitations by enhancing Universal Logit Distillation (ULD) with Top-K selection and Logits Standardization. We propose two fusion strategies: Pairwise Fusion (InfiFusion_p), where each source model knowledge is distilled individually into the pivot model followed by merging and Unified Fusion (InfiFusion_u), where knowledge from all source models is distilled simultaneously into the pivot model. InfiFusion outperforms the state-of-the-art models, such as Qwen-2.5-14B-Instruct and Phi-4, across 11 widely applied benchmarks covering reasoning, coding, mathematics, and instruction-following tasks. Notably, InfiFusion achieves this superior performance while significantly reduces computational costs, completing full training with only 160 H800 GPU hours compared to the millions typically required for traditional LLM training.

Combining several (sample approximations of) distributions, which we term sub-posteriors, into a single distribution proportional to their product, is a common challenge. Occurring, for instance, in distributed 'big data' problems, or when working under multi-party privacy constraints. Many existing approaches resort to approximating the individual sub-posteriors for practical necessity, then find either an analytical approximation or sample approximation of the resulting (product-pooled) posterior. The quality of the posterior approximation for these approaches is poor when the sub-posteriors fall out-with a narrow range of distributional form, such as being approximately Gaussian. Recently, a Fusion approach has been proposed which finds an exact Monte Carlo approximation of the posterior, circumventing the drawbacks of approximate approaches. Unfortunately, existing Fusion approaches have a number of computational limitations, particularly when unifying a large number of sub-posteriors. In this paper, we generalise the theory underpinning existing Fusion approaches, and embed the resulting methodology within a recursive divide-and-conquer sequential Monte Carlo paradigm. This ultimately leads to a competitive Fusion approach, which is robust to increasing numbers of sub-posteriors.

While fusing the capacities and advantages of various large language models (LLMs) offers a pathway to construct more powerful and versatile models, a fundamental challenge is to properly select advantageous model during the training. Existing fusion methods primarily focus on the training mode that uses cross entropy on ground truth in a teacher-forcing setup to measure a model's advantage, which may provide limited insight towards model advantage. In this paper, we introduce a novel approach that enhances the fusion process by incorporating both the training and inference modes. Our method evaluates model advantage not only through cross entropy during training but also by considering inference outputs, providing a more comprehensive assessment. To combine the two modes effectively, we introduce ProFuser to progressively transition from inference mode to training mode. To validate ProFuser's effectiveness, we fused three models, including vicuna-7b-v1.5, Llama-2-7b-chat, and mpt-7b-8k-chat, and demonstrated the improved performance in knowledge, reasoning, and safety compared to baseline methods.

While training large language models (LLMs) from scratch can generate models with distinct functionalities and strengths, it comes at significant costs and may result in redundant capabilities. Alternatively, a cost-effective and compelling approach is to merge existing pre-trained LLMs into a more potent model. However, due to the varying architectures of these LLMs, directly blending their weights is impractical. In this paper, we introduce the notion of knowledge fusion for LLMs, aimed at combining the capabilities of existing LLMs and transferring them into a single LLM. By leveraging the generative distributions of source LLMs, we externalize their collective knowledge and unique strengths, thereby potentially elevating the capabilities of the target model beyond those of any individual source LLM. We validate our approach using three popular LLMs with different architectures--Llama-2, MPT, and OpenLLaMA--across various benchmarks and tasks. Our findings confirm that the fusion of LLMs can improve the performance of the target model across a range of capabilities such as reasoning, commonsense, and code generation. Our code, model weights, and data are public at https://github.com/fanqiwan/FuseLLM.

Medical Vision-Language Models (Med-VLMs) require reliable reasoning from fine-grained visual evidence, yet existing models can produce plausible clinical answers by relying on language priors or medical templates rather than truly attending to diagnosis-critical regions. On-Policy Distillation (OPD) offers dense token-level supervision on student-generated trajectories and provides a privacy-compatible means of capability transfer without requiring the redistribution of raw patient data. However, standard OPD uniformly distills all tokens, causing sparse evidence-dependent tokens to be diluted by abundant clinical narrative tokens. Inspired by the success of OPD in the large language model community, we propose Med-OPD, to our knowledge the first unified post-training framework that integrates on-policy distillation with medical evidence-aware supervision for Med-VLMs. We introduce Medical Evidence Advantage (MEA), a teacher-grounded counterfactual signal that uses an answer-aware hint to focus teacher scoring on evidence supporting the target diagnosis, and measures each token's dependence on medical visual evidence by comparing teacher likelihoods under the original and evidence-degraded imaging modalities. Based on MEA, Med-OPD redistributes the distillation signal at both the token and trajectory levels, emphasizing diagnosis-critical tokens and evidence-reliant rollouts. Experiments on OmniMedVQA subsets show that Med-OPD consistently outperforms SFT and standard OPD across CT, MRI, Disease Diagnosis, and Lesion Grading. These results demonstrate that evidence-aware distillation can better strengthen medical VLMs' reliance on key visual evidence and improve reliable multimodal medical reasoning. The source code and data is publicly available at: https://github.com/yunhang8658/MedOPD.git

Model fusion is a key strategy for robust recognition in unconstrained scenarios, as different models provide complementary strengths. This is especially important for whole-body human recognition, where biometric cues such as face, gait, and body shape vary across samples and are typically integrated via score-fusion. However, existing score-fusion strategies are usually static, invoking all models for every test sample regardless of sample quality or modality reliability. To overcome these limitations, we propose FusionAgent, a novel agentic framework that leverages a Multimodal Large Language Model (MLLM) to perform dynamic, sample-specific model selection. Each expert model is treated as a tool, and through Reinforcement Fine-Tuning (RFT) with a metric-based reward, the agent learns to adaptively determine the optimal model combination for each test input. To address the model score misalignment and embedding heterogeneity, we introduce Anchor-based Confidence Top-k (ACT) score-fusion, which anchors on the most confident model and integrates complementary predictions in a confidence-aware manner. Extensive experiments on multiple whole-body biometric benchmarks demonstrate that FusionAgent significantly outperforms SoTA methods while achieving higher efficiency through fewer model invocations, underscoring the critical role of dynamic, explainable, and robust model fusion in real-world recognition systems. Project page: https://fusionagent.github.io/{FusionAgent}.

Evidence-grounded reasoning requires more than attaching retrieved text to a prediction: a model should make decisions that depend on whether the provided evidence supports the target claim. In practice, this often fails because supervision is weak, evidence is only loosely tied to the claim, and evaluation does not test evidence dependence directly. We introduce case-grounded evidence verification, a general framework in which a model receives a local case context, external evidence, and a structured claim, and must decide whether the evidence supports the claim for that case. Our key contribution is a supervision construction procedure that generates explicit support examples together with semantically controlled non-support examples, including counterfactual wrong-state and topic-related negatives, without manual evidence annotation. We instantiate the framework in radiology and train a standard verifier on the resulting support task. The learned verifier substantially outperforms both case-only and evidence-only baselines, remains strong under correct evidence, and collapses when evidence is removed or swapped, indicating genuine evidence dependence. This behavior transfers across unseen evidence articles and an external case distribution, though performance degrades under evidence-source shift and remains sensitive to backbone choice. Overall, the results suggest that a major bottleneck in evidence grounding is not only model capacity, but the lack of supervision that encodes the causal role of evidence.

Multi-step visual retrieval-augmented generation (RAG) answers complex questions by repeatedly retrieving visual evidence, updating an intermediate state, and deciding whether to continue searching or answer. Yet retrieving relevant evidence does not ensure its effective use throughout the reasoning trajectory. As multi-step reasoning progresses, redundant sources occupy context capacity needed for missing evidence, observations tied to resolved requirements or unproductive searches linger in context, and visual sources are revisited with insufficient detail for fine-grained reading. We term this loss of usable evidence over a reasoning trajectory trajectory-level evidence utilization degradation. To address it, we propose Trajectory-Aware Evidence Coordination (TAEC), a training-free framework that coordinates evidence use around unresolved answer requirements. TAEC tracks these requirements in a shared trajectory state to guide which evidence enters the context, how accumulated memory is retained, and at what level of detail visual evidence is examined. Under a unified evaluation protocol on ViDoSeek, SlideVQA, and MMLongBench-Doc, TAEC achieves the best overall performance against leading training-free visual RAG baselines, with the highest average accuracy across multiple proprietary vision-language models. These results demonstrate that aligning evidence with evolving reasoning needs improves evidence use throughout multi-step visual RAG.

Pretraining has been shown to scale well with compute, data size and data diversity. Multitask learning trains on a mixture of supervised datasets and produces improved performance compared to self-supervised pretraining. Until now, massively multitask learning required simultaneous access to all datasets in the mixture and heavy compute resources that are only available to well-resourced teams. In this paper, we propose ColD Fusion, a method that provides the benefits of multitask learning but leverages distributed computation and requires limited communication and no sharing of data. Consequentially, ColD Fusion can create a synergistic loop, where finetuned models can be recycled to continually improve the pretrained model they are based on. We show that ColD Fusion yields comparable benefits to multitask pretraining by producing a model that (a) attains strong performance on all of the datasets it was multitask trained on and (b) is a better starting point for finetuning on unseen datasets. We find ColD Fusion outperforms RoBERTa and even previous multitask models. Specifically, when training and testing on 35 diverse datasets, ColD Fusion-based model outperforms RoBERTa by 2.45 points in average without any changes to the architecture.

Multi-modality image fusion is a technique that combines information from different sensors or modalities, enabling the fused image to retain complementary features from each modality, such as functional highlights and texture details. However, effective training of such fusion models is challenging due to the scarcity of ground truth fusion data. To tackle this issue, we propose the Equivariant Multi-Modality imAge fusion (EMMA) paradigm for end-to-end self-supervised learning. Our approach is rooted in the prior knowledge that natural imaging responses are equivariant to certain transformations. Consequently, we introduce a novel training paradigm that encompasses a fusion module, a pseudo-sensing module, and an equivariant fusion module. These components enable the net training to follow the principles of the natural sensing-imaging process while satisfying the equivariant imaging prior. Extensive experiments confirm that EMMA yields high-quality fusion results for infrared-visible and medical images, concurrently facilitating downstream multi-modal segmentation and detection tasks. The code is available at https://github.com/Zhaozixiang1228/MMIF-EMMA.

Classification on long-tailed distributed data is a challenging problem, which suffers from serious class-imbalance and accordingly unpromising performance especially on tail classes. Recently, the ensembling based methods achieve the state-of-the-art performance and show great potential. However, there are two limitations for current methods. First, their predictions are not trustworthy for failure-sensitive applications. This is especially harmful for the tail classes where the wrong predictions is basically frequent. Second, they assign unified numbers of experts to all samples, which is redundant for easy samples with excessive computational cost. To address these issues, we propose a Trustworthy Long-tailed Classification (TLC) method to jointly conduct classification and uncertainty estimation to identify hard samples in a multi-expert framework. Our TLC obtains the evidence-based uncertainty (EvU) and evidence for each expert, and then combines these uncertainties and evidences under the Dempster-Shafer Evidence Theory (DST). Moreover, we propose a dynamic expert engagement to reduce the number of engaged experts for easy samples and achieve efficiency while maintaining promising performances. Finally, we conduct comprehensive experiments on the tasks of classification, tail detection, OOD detection and failure prediction. The experimental results show that the proposed TLC outperforms existing methods and is trustworthy with reliable uncertainty.

We present a hybrid retrieval system for COVID-19 scientific literature, evaluated on the TREC-COVID benchmark (171,332 papers, 50 expert queries). The system implements six retrieval configurations spanning sparse (SPLADE), dense (BGE), rank-level fusion (RRF), and a projection-based vector fusion (B5) approach. RRF fusion achieves the best relevance (nDCG@10 = 0.828), outperforming dense-only by 6.1% and sparse-only by 14.9%. Our projection fusion variant reaches nDCG@10 = 0.678 on expert queries while being 33% faster (847 ms vs. 1271 ms) and producing 2.2x higher ILD@10 than RRF. Evaluation across 400 queries -- including expert, machine-generated, and three paraphrase styles -- shows that B5 delivers the largest relative gain on keyword-heavy reformulations (+8.8%), although RRF remains best in absolute nDCG@10. On expert queries, MMR reranking increases intra-list diversity by 23.8-24.5% at a 20.4-25.4% nDCG@10 cost. Both fusion pipelines evaluated for latency remain below the sub-2 s target across all query sets. The system is deployed as a Streamlit web application backed by Pinecone serverless indices.

Accurate estimation of pasture biomass from agricultural imagery is critical for sustainable livestock management, yet existing methods are limited by the small, imbalanced, and sparsely annotated datasets typical of real world monitoring. In this study, adaptation of vision foundation models to agricultural regression is systematically evaluated on the CSIRO Pasture Biomass benchmark, a 357 image dual view dataset with laboratory validated, component wise ground truth for five biomass targets, through 17 configurations spanning four backbones (EfficientNet-B3 to DINOv3-ViT-L), five cross view fusion mechanisms, and a 4x2 metadata factorial. A counterintuitive principle, termed "fusion complexity inversion", is uncovered: on scarce agricultural data, a two layer gated depthwise convolution (R^2 = 0.903) outperforms cross view attention transformers (0.833), bidirectional SSMs (0.819), and full Mamba (0.793, below the no fusion baseline). Backbone pretraining scale is found to monotonically dominate all architectural choices, with the DINOv2 -> DINOv3 upgrade alone yielding +5.0 R^2 points. Training only metadata (species, state, and NDVI) is shown to create a universal ceiling at R^2 ~ 0.829, collapsing an 8.4 point fusion spread to 0.1 points. Actionable guidelines for sparse agricultural benchmarks are established: backbone quality should be prioritized over fusion complexity, local modules preferred over global alternatives, and features unavailable at inference excluded.

We present a complete theoretical characterization of Latent Posterior Factors (LPF), a principled framework for aggregating multiple heterogeneous evidence items in probabilistic prediction tasks. Multi-evidence reasoning arises pervasively in high-stakes domains including healthcare diagnosis, financial risk assessment, legal case analysis, and regulatory compliance, yet existing approaches either lack formal guarantees or fail to handle multi-evidence scenarios architecturally. LPF encodes each evidence item into a Gaussian latent posterior via a variational autoencoder, converting posteriors to soft factors through Monte Carlo marginalization, and aggregating factors via exact Sum-Product Network inference (LPF-SPN) or a learned neural aggregator (LPF-Learned). We prove seven formal guarantees spanning the key desiderata for trustworthy AI: Calibration Preservation (ECE <= epsilon + C/sqrt(K_eff)); Monte Carlo Error decaying as O(1/sqrt(M)); a non-vacuous PAC-Bayes bound with train-test gap of 0.0085 at N=4200; operation within 1.12x of the information-theoretic lower bound; graceful degradation as O(epsilon*delta*sqrt(K)) under corruption, maintaining 88% performance with half of evidence adversarially replaced; O(1/sqrt(K)) calibration decay with R^2=0.849; and exact epistemic-aleatoric uncertainty decomposition with error below 0.002%. All theorems are empirically validated on controlled datasets spanning up to 4,200 training examples. Our theoretical framework establishes LPF as a foundation for trustworthy multi-evidence AI in safety-critical applications.

Evaluating Large Language Models (LLMs) is a complex task, especially considering the intricacies of natural language understanding and the expectations for high-level reasoning. Traditional evaluations typically lean on human-based, model-based, or automatic-metrics-based paradigms, each with its own advantages and shortcomings. We introduce "Fusion-Eval", a system that employs LLMs not solely for direct evaluations, but to skillfully integrate insights from diverse evaluators. This gives Fusion-Eval flexibility, enabling it to work effectively across diverse tasks and make optimal use of multiple references. In testing on the SummEval dataset, Fusion-Eval achieved a Spearman correlation of 0.96, outperforming other evaluators. The success of Fusion-Eval underscores the potential of LLMs to produce evaluations that closely align human perspectives, setting a new standard in the field of LLM evaluation.

Psychiatric consultation requires agents to elicit discriminative evidence, map uncertain narratives to diagnostic criteria, and decide when evidence suffices. Existing dialogue and retrieval-augmented systems condition policies on raw histories or appended passages, leaving observed evidence, missing checks, differentials, and support reliability entangled. We introduce MIND, a criteria-grounded evidence-state decision interface. At each turn, MIND constructs a typed state containing observed evidence, unresolved criterion checks, active differentials, criterion-linked supports, and reliability metadata. A training-split Psychiatric Reasoning Bank supplies gated supports, turning retrieval into state construction rather than prompt injection. The same state conditions action selection, process rewards, information-gain scoring, and trajectory rectification. Under EMR-grounded simulator protocols, MIND improves accuracy by 8.8 and 7.3 points over strong inference-only, RAG, and RL baselines, with gains transferring to public MDD-5k dialogues. Matched interventions attribute these gains to the shared state rather than prompt length, retrieval text, or formatting. MIND targets screening-level decision support, not autonomous diagnosis. Code is available at https://github.com/Lingxi-mental-health/MIND.Å

Multi-modality image fusion aims to combine different modalities to produce fused images that retain the complementary features of each modality, such as functional highlights and texture details. To leverage strong generative priors and address challenges such as unstable training and lack of interpretability for GAN-based generative methods, we propose a novel fusion algorithm based on the denoising diffusion probabilistic model (DDPM). The fusion task is formulated as a conditional generation problem under the DDPM sampling framework, which is further divided into an unconditional generation subproblem and a maximum likelihood subproblem. The latter is modeled in a hierarchical Bayesian manner with latent variables and inferred by the expectation-maximization (EM) algorithm. By integrating the inference solution into the diffusion sampling iteration, our method can generate high-quality fused images with natural image generative priors and cross-modality information from source images. Note that all we required is an unconditional pre-trained generative model, and no fine-tuning is needed. Our extensive experiments indicate that our approach yields promising fusion results in infrared-visible image fusion and medical image fusion. The code is available at https://github.com/Zhaozixiang1228/MMIF-DDFM.

With a rapidly increasing amount and diversity of remote sensing (RS) data sources, there is a strong need for multi-view learning modeling. This is a complex task when considering the differences in resolution, magnitude, and noise of RS data. The typical approach for merging multiple RS sources has been input-level fusion, but other - more advanced - fusion strategies may outperform this traditional approach. This work assesses different fusion strategies for crop classification in the CropHarvest dataset. The fusion methods proposed in this work outperform models based on individual views and previous fusion methods. We do not find one single fusion method that consistently outperforms all other approaches. Instead, we present a comparison of multi-view fusion methods for three different datasets and show that, depending on the test region, different methods obtain the best performance. Despite this, we suggest a preliminary criterion for the selection of fusion methods.

AI holds promise for transforming scientific processes, including hypothesis generation. Prior work on hypothesis generation can be broadly categorized into theory-driven and data-driven approaches. While both have proven effective in generating novel and plausible hypotheses, it remains an open question whether they can complement each other. To address this, we develop the first method that combines literature-based insights with data to perform LLM-powered hypothesis generation. We apply our method on five different datasets and demonstrate that integrating literature and data outperforms other baselines (8.97\% over few-shot, 15.75\% over literature-based alone, and 3.37\% over data-driven alone). Additionally, we conduct the first human evaluation to assess the utility of LLM-generated hypotheses in assisting human decision-making on two challenging tasks: deception detection and AI generated content detection. Our results show that human accuracy improves significantly by 7.44\% and 14.19\% on these tasks, respectively. These findings suggest that integrating literature-based and data-driven approaches provides a comprehensive and nuanced framework for hypothesis generation and could open new avenues for scientific inquiry.

Retrieval-augmented generation (RAG) improves large language models (LMs) by incorporating non-parametric knowledge through evidence retrieved from external sources. However, it often struggles to cope with inconsistent and irrelevant information that can distract the LM from its tasks, especially when multiple evidence pieces are required. While compressing the retrieved evidence with a compression model aims to address this issue, the compressed evidence may still be unfamiliar to the target model used for downstream tasks, potentially failing to utilize the evidence effectively. We propose FaviComp (Familarity-Aware Evidence Compression), a novel training-free evidence compression technique that makes retrieved evidence more familiar to the target model, while seamlessly integrating parametric knowledge from the model. Experimental results show that FaviComp consistently outperforms most recent evidence compression baselines across multiple open-domain QA datasets, improving accuracy by up to 28.1% while achieving high compression rates. Additionally, we demonstrate the effective integration of both parametric and non-parametric knowledge during evidence compression.

Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented generation (RAG) has been widely adopted to address these limitations by supplementing model outputs with retrieved evidence. However, whether RAG reliably achieves these goals remains unclear. Here, we present the most comprehensive expert evaluation of RAG in medicine to date. Eighteen medical experts contributed a total of 80,502 annotations, assessing 800 model outputs generated by GPT-4o and Llama-3.1-8B across 200 real-world patient and USMLE-style queries. We systematically decomposed the RAG pipeline into three components: (i) evidence retrieval (relevance of retrieved passages), (ii) evidence selection (accuracy of evidence usage), and (iii) response generation (factuality and completeness of outputs). Contrary to expectation, standard RAG often degraded performance: only 22% of top-16 passages were relevant, evidence selection remained weak (precision 41-43%, recall 27-49%), and factuality and completeness dropped by up to 6% and 5%, respectively, compared with non-RAG variants. Retrieval and evidence selection remain key failure points for the model, contributing to the overall performance drop. We further show that simple yet effective strategies, including evidence filtering and query reformulation, substantially mitigate these issues, improving performance on MedMCQA and MedXpertQA by up to 12% and 8.2%, respectively. These findings call for re-examining RAG's role in medicine and highlight the importance of stage-aware evaluation and deliberate system design for reliable medical LLM applications.

Diffusion models have been widely used for conditional data cross-modal generation tasks such as text-to-image and text-to-video. However, state-of-the-art models still fail to align the generated visual concepts with high-level semantics in a language such as object count, spatial relationship, etc. We approach this problem from a multimodal data fusion perspective and investigate how different fusion strategies can affect vision-language alignment. We discover that compared to the widely used early fusion of conditioning text in a pretrained image feature space, a specially designed intermediate fusion can: (i) boost text-to-image alignment with improved generation quality and (ii) improve training and inference efficiency by reducing low-rank text-to-image attention calculations. We perform experiments using a text-to-image generation task on the MS-COCO dataset. We compare our intermediate fusion mechanism with the classic early fusion mechanism on two common conditioning methods on a U-shaped ViT backbone. Our intermediate fusion model achieves a higher CLIP Score and lower FID, with 20% reduced FLOPs, and 50% increased training speed compared to a strong U-ViT baseline with an early fusion.

Multimodal perception forms the foundation of multimodal intelligence. In particular, spatial perception and multimodal long-context understanding are two pivotal tasks that underpin embodied AI and multimodal agents. However, synthesizing targeted, high-quality training data for these tasks remains difficult and costly. Our key insight is that these tasks share an underlying capability, which we call connecting evidence: identifying relevant visual facts, binding them to the correct entities, recovering their relations, and composing them into an answer. Crucially, targeted training data are far easier to synthesize for this capability than for these tasks themselves. To strengthen this capability, we propose EvidenceConnect, an easy-to-implement data synthesis framework that uses zoomed views of related regions within a single image to generate questions requiring comparison, aggregation, or chaining of visual evidence. To ensure quality, a reference answer is retained only when independent VLMs agree on it, and region-ablation tests discard questions whose answer survives the removal of selected regions. We then train base VLMs on the resulting data with RLVR, obtaining Zooming without Zooming v2 (ZwZ2). Although the synthesized data are not tailored to any downstream benchmark, ZwZ2 improves fine-grained and spatial perception, with further gains on embodied spatial reasoning, multimodal long-context understanding, multimodal agent tasks, and general visual reasoning. These results establish EvidenceConnect as an effective framework for supervising evidence connection and suggest that strengthening this shared capability leads to more generalizable multimodal perception.

The multifaceted nature of human perception and comprehension indicates that, when we think, our body can naturally take any combination of senses, a.k.a., modalities and form a beautiful picture in our brain. For example, when we see a cattery and simultaneously perceive the cat's purring sound, our brain can construct a picture of a cat in the cattery. Intuitively, generative AI models should hold the versatility of humans and be capable of generating images from any combination of modalities efficiently and collaboratively. This paper presents ImgAny, a novel end-to-end multi-modal generative model that can mimic human reasoning and generate high-quality images. Our method serves as the first attempt in its capacity of efficiently and flexibly taking any combination of seven modalities, ranging from language, audio to vision modalities, including image, point cloud, thermal, depth, and event data. Our key idea is inspired by human-level cognitive processes and involves the integration and harmonization of multiple input modalities at both the entity and attribute levels without specific tuning across modalities. Accordingly, our method brings two novel training-free technical branches: 1) Entity Fusion Branch ensures the coherence between inputs and outputs. It extracts entity features from the multi-modal representations powered by our specially constructed entity knowledge graph; 2) Attribute Fusion Branch adeptly preserves and processes the attributes. It efficiently amalgamates distinct attributes from diverse input modalities via our proposed attribute knowledge graph. Lastly, the entity and attribute features are adaptively fused as the conditional inputs to the pre-trained Stable Diffusion model for image generation. Extensive experiments under diverse modality combinations demonstrate its exceptional capability for visual content creation.

RLVR and OPD have become standard paradigms for post-training. We provide a unified analysis of these two paradigms in consolidating multiple expert capabilities into a single model, identifying capability loss in different ways: mixed RLVR suffers from inter-capability divergence cost, while the pipeline of first training experts and then performing OPD, though avoiding divergence, fails to fully absorb teacher capabilities due to large behavioral pattern gaps between teacher and student. We propose Co-Evolving Policy Distillation (CoPD), which encourages parallel training of experts and introduces OPD during each expert's ongoing RLVR training rather than after complete expert training, with experts serving as mutual teachers (making OPD bidirectional) to co-evolve. This enables more consistent behavioral patterns among experts while maintaining sufficient complementary knowledge throughout. Experiments validate that CoPD achieves all-in-one integration of text, image, and video reasoning capabilities, significantly outperforming strong baselines such as mixed RLVR and MOPD, and even surpassing domain-specific experts. The model parallel training pattern offered by CoPD may inspire a novel training scaling paradigm.

Accurate segmentation of tumors in PET/CT images is important in computer-aided diagnosis and treatment of cancer. The key issue of such a segmentation problem lies in the effective integration of complementary information from PET and CT images. However, the quality of PET and CT images varies widely in clinical settings, which leads to uncertainty in the modality information extracted by networks. To take the uncertainty into account in multi-modal information fusion, this paper proposes a novel Multi-modal Evidential Fusion Network (MEFN) comprising a Cross-Modal Feature Learning (CFL) module and a Multi-modal Trusted Fusion (MTF) module. The CFL module reduces the domain gap upon modality conversion and highlights common tumor features, thereby alleviating the needs of the segmentation module to handle modality specificity. The MTF module utilizes mutual attention mechanisms and an uncertainty calibrator to fuse modality features based on modality uncertainty and then fuse the segmentation results under the guidance of Dempster-Shafer Theory. Besides, a new uncertainty perceptual loss is introduced to force the model focusing on uncertain features and hence improve its ability to extract trusted modality information. Extensive comparative experiments are conducted on two publicly available PET/CT datasets to evaluate the performance of our proposed method whose results demonstrate that our MEFN significantly outperforms state-of-the-art methods with improvements of 2.15% and 3.23% in DSC scores on the AutoPET dataset and the Hecktor dataset, respectively. More importantly, our model can provide radiologists with credible uncertainty of the segmentation results for their decision in accepting or rejecting the automatic segmentation results, which is particularly important for clinical applications. Our code will be available at https://github.com/QPaws/MEFN.

Autonomous research agents must acquire and reason over evidence within a limited budget. Yet relevant sources can remain uninspected or unused, leaving a gap between retrieval coverage and the evidence that informs research. The challenge is to align fast local judgments with changing evidence needs and feed their findings back into research decisions. We introduce JevGPT, a dual-system architecture for autonomous research that couples fast evidence processing with deliberative research planning. System Two sets evidence objectives and integrates findings, while System One locates support, assesses relevance, and guides further inspection. Independent source judgments run in parallel; selected original passages inform the next research step. Experiments on fixed-corpus question answering and document ranking show that JevGPT achieves leading task performance, with faster completion and lower cost than comparably effective research agents. Evidence analysis shows broader source inspection and greater coverage of supporting documents in the research loop, highlighting efficient evidence processing as a route to more capable autonomous research.

Evaluating whether multimodal large language models truly understand long-form scientific papers remains challenging: answer-only metrics and synthetic "Needle-In-A-Haystack" tests often reward answer matching without requiring a causal, evidence-linked reasoning trace in the document. We propose the "Fish-in-the-Ocean" (FITO) paradigm, which requires models to construct explicit cross-modal evidence chains within native scientific documents. To operationalize FITO, we build SIN-Data, a scientific interleaved corpus that preserves the native interleaving of text and figures. On top of it, we construct SIN-Bench with four progressive tasks covering evidence discovery (SIN-Find), hypothesis verification (SIN-Verify), grounded QA (SIN-QA), and evidence-anchored synthesis (SIN-Summary). We further introduce "No Evidence, No Score", scoring predictions when grounded to verifiable anchors and diagnosing evidence quality via matching, relevance, and logic. Experiments on eight MLLMs show that grounding is the primary bottleneck: Gemini-3-pro achieves the best average overall score (0.573), while GPT-5 attains the highest SIN-QA answer accuracy (0.767) but underperforms on evidence-aligned overall scores, exposing a gap between correctness and traceable support.

Synthesizing clinical evidence largely relies on systematic reviews of clinical trials and retrospective analyses from medical literature. However, the rapid expansion of publications presents challenges in efficiently identifying, summarizing, and updating clinical evidence. Here, we introduce TrialMind, a generative artificial intelligence (AI) pipeline for facilitating human-AI collaboration in three crucial tasks for evidence synthesis: study search, screening, and data extraction. To assess its performance, we chose published systematic reviews to build the benchmark dataset, named TrialReviewBench, which contains 100 systematic reviews and the associated 2,220 clinical studies. Our results show that TrialMind excels across all three tasks. In study search, it generates diverse and comprehensive search queries to achieve high recall rates (Ours 0.711-0.834 v.s. Human baseline 0.138-0.232). For study screening, TrialMind surpasses traditional embedding-based methods by 30% to 160%. In data extraction, it outperforms a GPT-4 baseline by 29.6% to 61.5%. We further conducted user studies to confirm its practical utility. Compared to manual efforts, human-AI collaboration using TrialMind yielded a 71.4% recall lift and 44.2% time savings in study screening and a 23.5% accuracy lift and 63.4% time savings in data extraction. Additionally, when comparing synthesized clinical evidence presented in forest plots, medical experts favored TrialMind's outputs over GPT-4's outputs in 62.5% to 100% of cases. These findings show the promise of LLM-based approaches like TrialMind to accelerate clinical evidence synthesis via streamlining study search, screening, and data extraction from medical literature, with exceptional performance improvement when working with human experts.

Chest X-ray (CXR) interpretation often requires integrating visual findings with task-specific evidence rather than relying on direct visual recognition alone. While tool-augmented medical agents can supply such evidence via external modules, they often lack explicit mechanisms for learning when auxiliary evidence is needed and for preventing inapplicable quantitative evidence from entering diagnostic reasoning. To address this, we propose X-Ragent, a post-training framework for tool-augmented reinforcement learning that decouples learned auxiliary-evidence seeking from validity-gated quantitative measurement acquisition for evidence-grounded CXR reasoning. We construct Rad-CoT, a 7.7K-sample corpus combining causally ordered tool-augmented trajectories with report-style diagnostic reasoning, and use it to initialize Qwen3-VL-8B via agentic supervised fine-tuning (SFT). We then optimize the policy with Group Relative Policy Optimization (GRPO) using an accuracy-gated reward that applies process-level terms for measurement consistency and auxiliary-tool cost only to correct trajectories, preventing plausible process behavior from compensating for an incorrect diagnosis. Across three CXR benchmarks, X-Ragent achieves the strongest results, including an 8.6-point improvement on the fully held-out ChestAgentBench. By seeking evidence selectively and admitting only valid measurements, X-Ragent supports more faithful and evidence-grounded CXR reasoning.

Whole-slide images (WSIs) are challenging for vision-language reasoning because diagnostically relevant morphology is sparse, heterogeneous, and distributed across gigapixel-scale images and multiple spatial resolutions. Existing WSI models and pathology agents can aggregate slide features or actively acquire evidence, but the information retained after exploration is often difficult to access semantically while preserving its connection to the original visual evidence. We introduce SlideBank, a training-free framework that represents each WSI as a persistent, concept-indexed, and spatially grounded evidence bank. SlideBank performs question-independent coarse-to-fine exploration to identify informative regions and multi-scale views, converts them into explicit morphological observations, and grounds pathology signals to their supporting patches and WSI coordinates. At inference time, questions are routed to relevant signals and evidence scales, and the linked global, regional, and patch evidence is integrated through confidence-based cross-level consensus. Experiments on WSI-VQA and SlideBench-BCNB show that with Patho-R1, SlideBank reaches 52.77% on WSI-VQA and with Quilt-LLaVA, it reaches 50.92% average accuracy on SlideBench-BCNB, while structured signal-guided retrieval consistently outperforms random evidence sampling. Reusing the same bank across repeated queries further achieves over 99% rephrasing consistency and substantially reduces amortized inference cost through persistent evidence reuse.

Agentic retrieval-augmented reasoning pipelines are increasingly used to structure how large language models (LLMs) incorporate external evidence in clinical decision support. These systems iteratively retrieve curated domain knowledge and synthesize it into structured reports before answer selection. Although such pipelines can improve performance, their impact on reliability under model variability remains unclear. In real-world deployment, heterogeneous models may align, diverge, or synchronize errors in ways not captured by accuracy. We evaluated 34 LLMs on 169 expert-curated publicly available radiology questions, comparing zero-shot inference with a radiology-specific multi-step agentic retrieval condition in which all models received identical structured evidence reports derived from curated radiology knowledge. Agentic inference reduced inter-model decision dispersion (median entropy 0.48 vs. 0.13) and increased robustness of correctness across models (mean 0.74 vs. 0.81). Majority consensus also increased overall (P<0.001). Consensus strength and robust correctness remained correlated under both strategies (ho=0.88 for zero-shot; ho=0.87 for agentic), although high agreement did not guarantee correctness. Response verbosity showed no meaningful association with correctness. Among 572 incorrect outputs, 72% were associated with moderate or high clinically assessed severity, although inter-rater agreement was low (appa=0.02). Agentic retrieval therefore was associated with more concentrated decision distributions, stronger consensus, and higher cross-model robustness of correctness. These findings suggest that evaluating agentic systems through accuracy or agreement alone may not always be sufficient, and that complementary analyses of stability, cross-model robustness, and potential clinical impact are needed to characterize reliability under model variability.

Professional-document review is a constraint-checking problem in which decisions depend on relations among text, geometry, pages, and document revisions. We present an evidence-grounded pipeline that normalizes extracted facts, executes four-state rules deterministically, retains source spans, and escalates unresolved cases. We evaluate its PDF evidence allocator on 160 reference-based tasks from 29 construction projects using a repeated four-system test and a disjoint two-system breadth extension. In the repeated test, reallocating a four-image budget from retrieved page overviews to one overview and three overlapping tiles improves project-family standardized decision accuracy by 10.6 percentage points (95% project-cluster bootstrap CI: 4.3 to 18.0; exact p = 0.031). This effect does not persist in the broader block: Region-RAG changes accuracy by -4.1 points (95% CI: -10.2 to 1.9; exact p = 0.209), while an equal-image sensitivity favors page breadth. Exact finding-set recovery remains low, false passes remain common, and repeated-run agreement is poorly calibrated. The results identify a resolution-breadth trade-off rather than a universal advantage for region-focused evidence, motivating rule-aware evidence routing and expert review.

Pre-trained Vision-Language Models (VLMs) face a significant adaptation gap when applied to Zero-Shot Anomaly Detection (ZSAD), stemming from their lack of local inductive biases for dense prediction and their reliance on inflexible feature fusion paradigms. We address these limitations through an Architectural Co-Design framework that jointly refines feature representation and cross-modal fusion. Our method proposes a parameter-efficient Convolutional Low-Rank Adaptation (Conv-LoRA) adapter to inject local inductive biases for fine-grained representation, and introduces a Dynamic Fusion Gateway (DFG) that leverages visual context to adaptively modulate text prompts, enabling a powerful bidirectional fusion. Extensive experiments on diverse industrial and medical benchmarks demonstrate superior accuracy and robustness, validating that this synergistic co-design is critical for robustly adapting foundation models to dense perception tasks.

How do we most effectively treat a disease or condition? Ideally, we could consult a database of evidence gleaned from clinical trials to answer such questions. Unfortunately, no such database exists; clinical trial results are instead disseminated primarily via lengthy natural language articles. Perusing all such articles would be prohibitively time-consuming for healthcare practitioners; they instead tend to depend on manually compiled systematic reviews of medical literature to inform care. NLP may speed this process up, and eventually facilitate immediate consult of published evidence. The Evidence Inference dataset was recently released to facilitate research toward this end. This task entails inferring the comparative performance of two treatments, with respect to a given outcome, from a particular article (describing a clinical trial) and identifying supporting evidence. For instance: Does this article report that chemotherapy performed better than surgery for five-year survival rates of operable cancers? In this paper, we collect additional annotations to expand the Evidence Inference dataset by 25\%, provide stronger baseline models, systematically inspect the errors that these make, and probe dataset quality. We also release an abstract only (as opposed to full-texts) version of the task for rapid model prototyping. The updated corpus, documentation, and code for new baselines and evaluations are available at http://evidence-inference.ebm-nlp.com/.

Fusion is a technique for merging multiple independently-trained neural networks in order to combine their capabilities. Past attempts have been restricted to the case of fully-connected, convolutional, and residual networks. In this paper, we present a systematic approach for fusing two or more transformer-based networks exploiting Optimal Transport to (soft-)align the various architectural components. We flesh out an abstraction for layer alignment, that can generalize to arbitrary architectures -- in principle -- and we apply this to the key ingredients of Transformers such as multi-head self-attention, layer-normalization, and residual connections, and we discuss how to handle them via various ablation studies. Furthermore, our method allows the fusion of models of different sizes (heterogeneous fusion), providing a new and efficient way for compression of Transformers. The proposed approach is evaluated on both image classification tasks via Vision Transformer and natural language modeling tasks using BERT. Our approach consistently outperforms vanilla fusion, and, after a surprisingly short finetuning, also outperforms the individual converged parent models. In our analysis, we uncover intriguing insights about the significant role of soft alignment in the case of Transformers. Our results showcase the potential of fusing multiple Transformers, thus compounding their expertise, in the budding paradigm of model fusion and recombination.

Fine-tuning pre-trained language models has become the prevalent paradigm for building downstream NLP models. Oftentimes fine-tuned models are readily available but their training data is not, due to data privacy or intellectual property concerns. This creates a barrier to fusing knowledge across individual models to yield a better single model. In this paper, we study the problem of merging individual models built on different training data sets to obtain a single model that performs well both across all data set domains and can generalize on out-of-domain data. We propose a dataless knowledge fusion method that merges models in their parameter space, guided by weights that minimize prediction differences between the merged model and the individual models. Over a battery of evaluation settings, we show that the proposed method significantly outperforms baselines such as Fisher-weighted averaging or model ensembling. Further, we find that our method is a promising alternative to multi-task learning that can preserve or sometimes improve over the individual models without access to the training data. Finally, model merging is more efficient than training a multi-task model, thus making it applicable to a wider set of scenarios.

Zero-shot learning (ZSL) enables the recognition of novel classes by leveraging semantic knowledge transfer from known to unknown categories. This knowledge, typically encapsulated in attribute descriptions, aids in identifying class-specific visual features, thus facilitating visual-semantic alignment and improving ZSL performance. However, real-world challenges such as distribution imbalances and attribute co-occurrence among instances often hinder the discernment of local variances in images, a problem exacerbated by the scarcity of fine-grained, region-specific attribute annotations. Moreover, the variability in visual presentation within categories can also skew attribute-category associations. In response, we propose a bidirectional cross-modal ZSL approach CREST. It begins by extracting representations for attribute and visual localization and employs Evidential Deep Learning (EDL) to measure underlying epistemic uncertainty, thereby enhancing the model's resilience against hard negatives. CREST incorporates dual learning pathways, focusing on both visual-category and attribute-category alignments, to ensure robust correlation between latent and observable spaces. Moreover, we introduce an uncertainty-informed cross-modal fusion technique to refine visual-attribute inference. Extensive experiments demonstrate our model's effectiveness and unique explainability across multiple datasets. Our code and data are available at: https://github.com/JethroJames/CREST

Large language models (LLMs) and agentic systems have shown promise for clinical decision support, but existing works largely assume that evidence has already been curated and handed to the model. Real-world clinical workflows instead require agents to actively seek, iteratively plan, and synthesize multimodal evidence from heterogeneous sources. In this paper, we introduce ClinSeekAgent, an automated agentic framework for dynamic multimodal evidence seeking that shifts the paradigm from passive evidence consumption to active evidence acquisition. Given only a clinical query and access to raw data sources, ClinSeekAgent gathers evidence by querying medical knowledge bases, navigating raw EHRs, and invoking medical imaging tools; refines its hypotheses as new information emerges; and integrates the collected evidence into grounded clinical decisions. ClinSeekAgent serves both as an inference-time agent for frontier LLMs and as a training-time pipeline for distilling high-quality agent trajectories into compact open-source models. To validate its inference-time effectiveness, we construct ClinSeek-Bench, which pairs Curated Input reasoning from fixed pre-selected evidence with Automated Evidence-Seeking over raw clinical data. On text-only EHR tasks, ClinSeekAgent improves Claude Opus 4.6 from 60.0 to 63.2 overall F1 and MiniMax M2.5 from 43.1 to 47.3, with positive risk-prediction gains in 7 out of 9 evaluated host models. On multimodal tasks, ClinSeekAgent improves Claude Opus 4.6 from 47.5 to 62.6 (+15.1); all evaluated models improve across the three CXR-related task groups. We further validate ClinSeekAgent as a training pipeline by distilling agentic evidence-seeking trajectories into ClinSeek-35B-A3B, which achieves 34.0 average F1 on existing AgentEHR-Bench, improving over its Qwen3.5-35B-A3B baseline by +11.9 points and approaching Claude Opus 4.6.

Although much research has focused on AI explanations to support decisions in complex information-seeking tasks such as fact-checking, the role of evidence is surprisingly under-researched. In our study, we systematically varied explanation type, AI prediction certainty, and correctness of AI system advice for non-expert participants, who evaluated the veracity of claims and AI system predictions. Participants were provided the option of easily inspecting the underlying evidence. We found that participants consistently relied on evidence to validate AI claims across all experimental conditions. When participants were presented with natural language explanations, evidence was used less frequently although they relied on it when these explanations seemed insufficient or flawed. Qualitative data suggests that participants attempted to infer evidence source reliability, despite source identities being deliberately omitted. Our results demonstrate that evidence is a key ingredient in how people evaluate the reliability of information presented by an AI system and, in combination with natural language explanations, offers valuable support for decision-making. Further research is urgently needed to understand how evidence ought to be presented and how people engage with it in practice.

Motivation: Biomedical question answering often requires evidence beyond topically retrieved literature, including gene alias resolution, database identifier normalization, and atlas-derived biological measurements. However, existing retrieval-augmented generation (RAG) systems typically follow a fixed workflow and lack an explicit mechanism for deciding when retrieved text is sufficient, when curated biomedical knowledge is required, or when executable evidence assembly over structured measurements should be invoked. This motivates a substrate-aware large language model (LLM) harness that selectively assembles sufficient evidence across literature, knowledge bases, and biological atlases. Results: We introduce BioHarness, an LLM harness for staged biomedical evidence assembly across literature retrieval, curated biomedical knowledge resources, and atlas-derived structured measurements. BioHarness first attempts to answer from reranked literature evidence and escalates through grounded cascade control to REPL-style evidence assembly only when the current evidence is uncertain, weakly grounded, or substrate-mismatched. Across 19,302 biomedical QA items spanning seven answer formats, BioHarness improves the pooled score from 65.9 to 71.0 over the strongest non-oracle baseline. Ablations, case studies, and backbone-scaling analyses show that these gains arise from repairing evidence-substrate mismatches through reranking, entity grounding, and structured measurement access, rather than from indiscriminately invoking more reasoning steps, retrieving additional literature, or relying on a particular answer-model scale.

Recent advances in large language models (LLMs) have intensified efforts to fuse heterogeneous open-source models into a unified system that inherits their complementary strengths. Existing logit-based fusion methods maintain inference efficiency but treat vocabulary dimensions independently, overlooking semantic dependencies encoded by cross-dimension interactions. These dependencies reflect how token types interact under a model's internal reasoning and are essential for aligning models with diverse generation behaviors. To explicitly model these dependencies, we propose InfiGFusion, the first structure-aware fusion framework with a novel Graph-on-Logits Distillation (GLD) loss. Specifically, we retain the top-k logits per output and aggregate their outer products across sequence positions to form a global co-activation graph, where nodes represent vocabulary channels and edges quantify their joint activations. To ensure scalability and efficiency, we design a sorting-based closed-form approximation that reduces the original O(n^4) cost of Gromov-Wasserstein distance to O(n log n), with provable approximation guarantees. Experiments across multiple fusion settings show that GLD consistently improves fusion quality and stability. InfiGFusion outperforms SOTA models and fusion baselines across 11 benchmarks spanning reasoning, coding, and mathematics. It shows particular strength in complex reasoning tasks, with +35.6 improvement on Multistep Arithmetic and +37.06 on Causal Judgement over SFT, demonstrating superior multi-step and relational inference.

Mammalian brains handle complex reasoning tasks in a gestalt manner by integrating information from regions of the brain that are specialised to individual sensory modalities. This allows for improved robustness and better generalisation ability. In contrast, deep neural networks are usually designed to process one particular information stream and susceptible to various types of adversarial perturbations. While many methods exist for detecting and defending against adversarial attacks, they do not generalise across a range of attacks and negatively affect performance on clean, unperturbed data. We developed a fusion model using a combination of background and foreground features extracted in parallel from Places-CNN and Imagenet-CNN. We tested the benefits of the fusion approach on preserving adversarial robustness for human perceivable (e.g., Gaussian blur) and network perceivable (e.g., gradient-based) attacks for CIFAR-10 and MS COCO data sets. For gradient based attacks, our results show that fusion allows for significant improvements in classification without decreasing performance on unperturbed data and without need to perform adversarial retraining. Our fused model revealed improvements for Gaussian blur type perturbations as well. The increase in performance from fusion approach depended on the variability of the image contexts; larger increases were seen for classes of images with larger differences in their contexts. We also demonstrate the effect of regularization to bias the classifier decision in the presence of a known adversary. We propose that this biologically inspired approach to integrate information across multiple modalities provides a new way to improve adversarial robustness that can be complementary to current state of the art approaches.

Multimodal rumor detectors increasingly rely on retrieved evidence, yet relevant evidence is not necessarily sufficient for verification. Missing provenance, duplicated reports, and unresolved contradictions can produce confident predictions without adequate support. We introduce SAFE-MR, a framework that separates claim veracity from evidence sufficiency. The method decomposes image-text posts into verifiable claims, constructs a relation-aware claim-evidence graph, and aggregates evidence using provenance and contextual compatibility. Separate veracity and sufficiency heads support selective prediction, while evidence interventions encourage stability under irrelevant additions and sensitivity to evidence removal. On NewsCLIPpings, VERITE, and XFacta, SAFE-MR achieves macro-F1 scores of 91.2%, 75.8%, and 85.2%, respectively. Against the matched backbone with evidence, its macro-F1 gains are 2.2, 4.9, and 4.8 percentage points. On the diagnostic selection set, SAFE-MR reduces AURC from 0.105 for maximum-probability rejection to 0.075 and lowers error at 80% coverage from 13.8% to 8.5%. Evidence-perturbation and ablation results support the role of sufficiency learning and intervention training in improving selective verification.

Text-driven infrared and visible image fusion has gained attention for enabling natural language to guide the fusion process. However, existing methods lack a goal-aligned task to supervise and evaluate how effectively the input text contributes to the fusion outcome. We observe that referring image segmentation (RIS) and text-driven fusion share a common objective: highlighting the object referred to by the text. Motivated by this, we propose RIS-FUSION, a cascaded framework that unifies fusion and RIS through joint optimization. At its core is the LangGatedFusion module, which injects textual features into the fusion backbone to enhance semantic alignment. To support multimodal referring image segmentation task, we introduce MM-RIS, a large-scale benchmark with 12.5k training and 3.5k testing triplets, each consisting of an infrared-visible image pair, a segmentation mask, and a referring expression. Extensive experiments show that RIS-FUSION achieves state-of-the-art performance, outperforming existing methods by over 11% in mIoU. Code and dataset will be released at https://github.com/SijuMa2003/RIS-FUSION.

Clinical diagnosis is a highly specialized discipline requiring both domain expertise and strict adherence to rigorous guidelines. While current AI-driven medical research predominantly focuses on knowledge graphs or natural text pretraining paradigms to incorporate medical knowledge, these approaches primarily rely on implicitly encoded knowledge within model parameters, neglecting task-specific knowledge required by diverse downstream tasks. To address this limitation, we propose Retrieval-Augmented Diagnosis (RAD), a novel framework that explicitly injects external knowledge into multimodal models directly on downstream tasks. Specifically, RAD operates through three key mechanisms: retrieval and refinement of disease-centered knowledge from multiple medical sources, a guideline-enhanced contrastive loss that constrains the latent distance between multi-modal features and guideline knowledge, and the dual transformer decoder that employs guidelines as queries to steer cross-modal fusion, aligning the models with clinical diagnostic workflows from guideline acquisition to feature extraction and decision-making. Moreover, recognizing the lack of quantitative evaluation of interpretability for multimodal diagnostic models, we introduce a set of criteria to assess the interpretability from both image and text perspectives. Extensive evaluations across four datasets with different anatomies demonstrate RAD's generalizability, achieving state-of-the-art performance. Furthermore, RAD enables the model to concentrate more precisely on abnormal regions and critical indicators, ensuring evidence-based, trustworthy diagnosis. Our code is available at https://github.com/tdlhl/RAD.

The real world is dynamic, yet most image fusion methods process static frames independently, ignoring temporal correlations in videos and leading to flickering and temporal inconsistency. To address this, we propose Unified Video Fusion (UniVF), a novel framework for temporally coherent video fusion that leverages multi-frame learning and optical flow-based feature warping for informative, temporally coherent video fusion. To support its development, we also introduce Video Fusion Benchmark (VF-Bench), the first comprehensive benchmark covering four video fusion tasks: multi-exposure, multi-focus, infrared-visible, and medical fusion. VF-Bench provides high-quality, well-aligned video pairs obtained through synthetic data generation and rigorous curation from existing datasets, with a unified evaluation protocol that jointly assesses the spatial quality and temporal consistency of video fusion. Extensive experiments show that UniVF achieves state-of-the-art results across all tasks on VF-Bench. Project page: https://vfbench.github.io.

Long-horizon agents often struggle to recover from failures whose causes lie several steps earlier, beyond what local reflection or backtracking can resolve. We introduce BELIEFWEAVER, a framework that combines persistent evidence across attempts with prospective reasoning over repair directions. It maintains a relational belief state over frontiers, attempts, observations, and checkpoints. Execution evidence updates related frontier priorities across attempts and rollback, while diagnostic evidence gates execution. An implicit world model (IWM) evaluates repair hypotheses, predicts progress, and identifies relations among frontiers to guide exploration. We further distill these recurring IWM reasoning components into a 9B student through supervised fine-tuning and on-policy distillation (OPD). Across three terminal-based benchmarks, BELIEFWEAVER improves aggregate final score by 5.1 percentage points over native Terminus-2 continuation, with positive trends in exploration efficiency. The distilled 9B student improves final score by 9.8 percentage points over the reported native baseline while reducing estimated teacher API cost by 54.8% relative to the matched teacher. These results show that persistent evidence and prospective reasoning can improve recovery in long-horizon agent tasks while substantially reducing reliance on teacher-model inference.

Over the past decade, wearable computing devices (``smart glasses'') have undergone remarkable advancements in sensor technology, design, and processing power, ushering in a new era of opportunity for high-density human behavior data. Equipped with wearable cameras, these glasses offer a unique opportunity to analyze non-verbal behavior in natural settings as individuals interact. Our focus lies in predicting engagement in dyadic interactions by scrutinizing verbal and non-verbal cues, aiming to detect signs of disinterest or confusion. Leveraging such analyses may revolutionize our understanding of human communication, foster more effective collaboration in professional environments, provide better mental health support through empathetic virtual interactions, and enhance accessibility for those with communication barriers. In this work, we collect a dataset featuring 34 participants engaged in casual dyadic conversations, each providing self-reported engagement ratings at the end of each conversation. We introduce a novel fusion strategy using Large Language Models (LLMs) to integrate multiple behavior modalities into a ``multimodal transcript'' that can be processed by an LLM for behavioral reasoning tasks. Remarkably, this method achieves performance comparable to established fusion techniques even in its preliminary implementation, indicating strong potential for further research and optimization. This fusion method is one of the first to approach ``reasoning'' about real-world human behavior through a language model. Smart glasses provide us the ability to unobtrusively gather high-density multimodal data on human behavior, paving the way for new approaches to understanding and improving human communication with the potential for important societal benefits. The features and data collected during the studies will be made publicly available to promote further research.

While training large language models (LLMs) from scratch can indeed lead to models with distinct capabilities and strengths, it incurs substantial costs and may lead to redundancy in competencies. Knowledge fusion aims to integrate existing LLMs of diverse architectures and capabilities into a more potent LLM through lightweight continual training, thereby reducing the need for costly LLM development. In this work, we propose a new framework for the knowledge fusion of chat LLMs through two main stages, resulting in FuseChat. Firstly, we conduct pairwise knowledge fusion on source chat LLMs of varying structures and scales to create multiple target LLMs with identical structure and size via lightweight fine-tuning. During this process, a statistics-based token alignment approach is introduced as the cornerstone for fusing LLMs with different structures. Secondly, we merge these target LLMs within the parameter space, where we propose a novel method for determining the merging coefficients based on the magnitude of parameter updates before and after fine-tuning. We implement and validate FuseChat using six prominent chat LLMs with diverse architectures and scales, including OpenChat-3.5-7B, Starling-LM-7B-alpha, NH2-SOLAR-10.7B, InternLM2-Chat-20B, Mixtral-8x7B-Instruct, and Qwen-1.5-Chat-72B. Experimental results on two instruction-following benchmarks, AlpacaEval 2.0 and MT-Bench, demonstrate the superiority of FuseChat-7B over baselines of various sizes. Our model is even comparable to the larger Mixtral-8x7B-Instruct and approaches GPT-3.5-Turbo-1106 on MT-Bench. Our code, model weights, and data are public at https://github.com/fanqiwan/FuseAI.

Multimodal Large Language Models (MLLMs) have recently been applied to universal multimodal retrieval, where Chain-of-Thought (CoT) reasoning improves candidate reranking. However, existing approaches remain largely language-driven, relying on static visual encodings and lacking the ability to actively verify fine-grained visual evidence, which often leads to speculative reasoning in visually ambiguous cases. We propose V-Retrver, an evidence-driven retrieval framework that reformulates multimodal retrieval as an agentic reasoning process grounded in visual inspection. V-Retrver enables an MLLM to selectively acquire visual evidence during reasoning via external visual tools, performing a multimodal interleaved reasoning process that alternates between hypothesis generation and targeted visual verification.To train such an evidence-gathering retrieval agent, we adopt a curriculum-based learning strategy combining supervised reasoning activation, rejection-based refinement, and reinforcement learning with an evidence-aligned objective. Experiments across multiple multimodal retrieval benchmarks demonstrate consistent improvements in retrieval accuracy (with 23.0% improvements on average), perception-driven reasoning reliability, and generalization.

Uncertainty estimation is a key factor that makes deep learning reliable in practical applications. Recently proposed evidential neural networks explicitly account for different uncertainties by treating the network's outputs as evidence to parameterize the Dirichlet distribution, and achieve impressive performance in uncertainty estimation. However, for high data uncertainty samples but annotated with the one-hot label, the evidence-learning process for those mislabeled classes is over-penalized and remains hindered. To address this problem, we propose a novel method, Fisher Information-based Evidential Deep Learning (I-EDL). In particular, we introduce Fisher Information Matrix (FIM) to measure the informativeness of evidence carried by each sample, according to which we can dynamically reweight the objective loss terms to make the network more focused on the representation learning of uncertain classes. The generalization ability of our network is further improved by optimizing the PAC-Bayesian bound. As demonstrated empirically, our proposed method consistently outperforms traditional EDL-related algorithms in multiple uncertainty estimation tasks, especially in the more challenging few-shot classification settings.

Misinformation in healthcare, from vaccine hesitancy to unproven treatments, poses risks to public health and trust in medical systems. While machine learning and natural language processing have advanced automated fact-checking, validating biomedical claims remains uniquely challenging due to complex terminology, the need for domain expertise, and the critical importance of grounding in scientific evidence. We introduce CER (Combining Evidence and Reasoning), a novel framework for biomedical fact-checking that integrates scientific evidence retrieval, reasoning via large language models, and supervised veracity prediction. By integrating the text-generation capabilities of large language models with advanced retrieval techniques for high-quality biomedical scientific evidence, CER effectively mitigates the risk of hallucinations, ensuring that generated outputs are grounded in verifiable, evidence-based sources. Evaluations on expert-annotated datasets (HealthFC, BioASQ-7b, SciFact) demonstrate state-of-the-art performance and promising cross-dataset generalization. Code and data are released for transparency and reproducibility: https: //github.com/PRAISELab-PicusLab/CER.

Chest X-ray imaging is crucial for diagnosing pulmonary and cardiac diseases, yet its interpretation demands extensive clinical experience and suffers from inter-observer variability. While deep learning models offer high diagnostic accuracy, their black-box nature hinders clinical adoption in high-stakes medical settings. To address this, we propose X-Ray-CoT (Chest X-Ray Chain-of-Thought), a novel framework leveraging Vision-Language Large Models (LVLMs) for intelligent chest X-ray diagnosis and interpretable report generation. X-Ray-CoT simulates human radiologists' "chain-of-thought" by first extracting multi-modal features and visual concepts, then employing an LLM-based component with a structured Chain-of-Thought prompting strategy to reason and produce detailed natural language diagnostic reports. Evaluated on the CORDA dataset, X-Ray-CoT achieves competitive quantitative performance, with a Balanced Accuracy of 80.52% and F1 score of 78.65% for disease diagnosis, slightly surpassing existing black-box models. Crucially, it uniquely generates high-quality, explainable reports, as validated by preliminary human evaluations. Our ablation studies confirm the integral role of each proposed component, highlighting the necessity of multi-modal fusion and CoT reasoning for robust and transparent medical AI. This work represents a significant step towards trustworthy and clinically actionable AI systems in medical imaging.

International Classification of Diseases (ICD) coding assigns diagnosis codes to clinical documents and is essential for healthcare billing and clinical analysis. Reliable coding requires that each predicted code be supported by explicit textual evidence. However, existing public datasets provide only code labels, without evidence annotations, limiting models' ability to learn evidence-grounded predictions. In this work, we argue that dense, document-level evidence annotation is not always necessary for learning evidence-based coding. Instead, models can learn code-specific evidence patterns from local spans and use these patterns to support document-level evidence-based coding. Based on this insight, we propose Span-Centric Learning (SCL), a training framework that strengthens LLMs' coding ability at the span level and transfers this capability to full clinical documents. Specifically, we use a small set of annotated documents to supervise evidence recognition, aggregation, and code assignment, while leveraging a large collection of lightweight evidence spans to reinforce span-level reasoning. Due to their compactness, span annotations are scalable and can be further augmented through synthesis. Under the same Llama3.1-8B backbone, our approach achieves an 8.2-point improvement in macro-F1 at only 20% of the training cost of standard SFT, and provides explicit supporting evidence for each predicted code, enabling human auditing and revision.

Sensor fusion of camera, LiDAR, and 4-dimensional (4D) Radar has brought a significant performance improvement in autonomous driving. However, there still exist fundamental challenges: deeply coupled fusion methods assume continuous sensor availability, making them vulnerable to sensor degradation and failure, whereas sensor-wise cross-attention fusion methods struggle with computational cost and unified feature representation. This paper presents availability-aware sensor fusion (ASF), a novel method that employs unified canonical projection (UCP) to enable consistency in all sensor features for fusion and cross-attention across sensors along patches (CASAP) to enhance robustness of sensor fusion against sensor degradation and failure. As a result, the proposed ASF shows a superior object detection performance to the existing state-of-the-art fusion methods under various weather and sensor degradation (or failure) conditions. Extensive experiments on the K-Radar dataset demonstrate that ASF achieves improvements of 9.7% in AP BEV (87.2%) and 20.1% in AP 3D (73.6%) in object detection at IoU=0.5, while requiring a low computational cost. All codes are available at https://github.com/kaist-avelab/k-radar.

Scientific agents contribute to hypothesis discovery by synthesizing evidence, assessing proposals, and developing new explanations. Recent systems combine scientific agents with evolutionary search through critique, comparison, and revision. However, how different forms of agent collaboration affect hypothesis quality remains an open question. Answering this question requires separating the effects of agents' scientific capabilities from those of their collaboration. A framework must therefore preserve agents' scientific roles and support rules for combining, revising, and retaining hypotheses. Building on this view, we introduce HypoEvolve, which makes collaboration explicit through successive updates to a hypothesis population. Specifically, we propose a generational genetic algorithm to coordinate specialized large language model (LLM) agents that integrate mechanistic arguments, reconsider assumptions, and assess evidence and testability. Each generation specifies how scientific judgments and new proposals reshape the population, making collaboration effects on hypothesis quality directly testable. Moreover, we design our evaluation around scientifically meaningful hypotheses that explain how a proposed intervention could work. Drug repurposing links these explanations to target-level biological claims assessed against external evidence. Specifically, we adapt DepMap and Open Targets into complementary external measures grounded in experimental, genetic, and clinical evidence. Across 34 cancer types, HypoEvolve achieves the highest scores against six baselines on both measures. DepMap selectivity reaches 0.171, versus 0.115 for the strongest baseline. Gains over single-pass generation also generalize to held-out cancer types. HypoEvolve advances a vision of autonomous science in which AI research teams achieve a capacity for discovery beyond that of individual models.

We present Mantis Shrimp, a multi-survey deep learning model for photometric redshift estimation that fuses ultra-violet (GALEX), optical (PanSTARRS), and infrared (UnWISE) imagery. Machine learning is now an established approach for photometric redshift estimation, with generally acknowledged higher performance in areas with a high density of spectroscopically identified galaxies over template-based methods. Multiple works have shown that image-based convolutional neural networks can outperform tabular-based color/magnitude models. In comparison to tabular models, image models have additional design complexities: it is largely unknown how to fuse inputs from different instruments which have different resolutions or noise properties. The Mantis Shrimp model estimates the conditional density estimate of redshift using cutout images. The density estimates are well calibrated and the point estimates perform well in the distribution of available spectroscopically confirmed galaxies with (bias = 1e-2), scatter (NMAD = 2.44e-2) and catastrophic outlier rate (eta=17.53%). We find that early fusion approaches (e.g., resampling and stacking images from different instruments) match the performance of late fusion approaches (e.g., concatenating latent space representations), so that the design choice ultimately is left to the user. Finally, we study how the models learn to use information across bands, finding evidence that our models successfully incorporates information from all surveys. The applicability of our model to the analysis of large populations of galaxies is limited by the speed of downloading cutouts from external servers; however, our model could be useful in smaller studies such as generating priors over redshift for stellar population synthesis.

As AI systems are increasingly used to draft radiology reports, reliably evaluating their clinical quality remains a critical challenge. Large language model (LLM)-based metrics are now the best-correlated with radiologist judgment, yet they output a single opaque score that neither a clinician nor a model builder can easily interpret or audit. We introduce RadMatch, a multi-stage, LLM-based metric that decomposes report comparison into a structured finding-level matching with significance-aware scoring and error characterization across seven clinical attribute dimensions (status, location, severity, morphology, certainty, longitudinal comparison, and measurement). The main score is the actionable-error count, both interpretable and auditable. Candidate findings are graded correct, partial, or incorrect, and unmatched findings are counted as missed or hallucinated. Triage and actionable safety recall/precision and per-subset views add complementary, deployment-oriented lenses. Across two expert benchmarks, RadMatch is the most clinically aligned metric, matching inter-radiologist agreement on ReXVal and more than doubling the best prior metric on the harder RadEvalExpert. Relying only on few-shot prompting, it is designed to extend to other modalities and anatomies. We will release RadMatch as open-source code with an interactive dashboard for inspecting results.

Agentic Entity Resolution (ER) systems iteratively plan actions, retrieve evidence, revise hypotheses, and propose graph mutations. An erroneous identity hypothesis may condition later retrieval and produce apparent confirmation. This paper proposes a Digital Identity Optimization (DIO) and Ontology of Digital Identity (ODI)-informed authorization boundary between evidence available for agent reasoning and evidence eligible to authorize persistent identity-changing mutations. A domain-governed constraint-binding function maps selected reconstruction-failure distinctions to explicit identity-preserving constraints. An abstract two-phase supervisor permits a commit only when claim-specific authorization-eligible evidence supports every required proposition, relevant conflicts are resolved, the operation remains within its authorized scope, and relevant state and policy versions remain valid. Admission as UNVERIFIED does not confer authorization eligibility. Separate claim-specific promotion governs evidentiary use; insufficient support or unresolved material conflict leads to deferral. The contribution is a specification connecting diagnostic-to-constraint mapping, evidence promotion, proposition coverage, conflict handling, scope binding, and commit-time version integrity. A proposed evaluation protocol is designed to assess the mapping's incremental value beyond generic authorization and conventional identifier rules. This is a conceptual architecture without implementation or empirical validation, not a theorem of semantic correctness. Its property depends on domain-policy adequacy, evidence promotion, and enforcement. It does not prevent erroneous hypotheses or hypothesis-conditioned retrieval; dependency-aware evidence flow remains future research.

Deep research agents are increasingly capable of web search, tool use, multimodal evidence analysis, and information synthesis. However, existing benchmarks mainly evaluate medium-horizon exploration and rarely test whether agents can sustain long, dependency-heavy research processes. We introduce Mr.LHDR (Multimodal real-world Long-Horizon Deep Research), a benchmark for evaluating real-world deep research over long, irreducible chains of interdependent evidence across eight categories. Each question is constructed from a hidden Node-Relation graph and requires an average of 12.1 necessary intermediate conclusions with a mean dependency depth of 10.4 before reaching a short, unique, and verifiable answer. Questions incorporate multimodal evidence, including images, maps, PDFs, logos, charts, tables, and video frames, with at least one non-text element that changes the reasoning state. Mr.LHDR evaluates both final answers and the correctness of intermediate conclusions under annotated dependencies. We evaluate general models, deep research systems, and agent frameworks using Overall Accuracy (OA), Strict Accuracy (SA), Checklist Score (CS), and Dependency-Aware Checklist Score (DACS). Results show that even the strongest system achieves only 43.1% OA and 34.3% SA, indicating that final-answer accuracy substantially overestimates complete research success. Removing images reduces DACS by 12.6 points, demonstrating the importance of multimodal evidence, while SA consistently declines as reasoning chains become longer. These findings reveal sustained, dependency-consistent evidence integration, rather than isolated fact retrieval, as a key bottleneck for current deep research agents.

Accurate quantification of lung disease severity from chest imaging is critical for clinical decision-making and resource allocation. We propose a tri-modal deep learning framework, TMF-RSE (Tri-Modal Fusion with Regional Semantics and Evidential Uncertainty), that combines appearance features from two-dimensional chest inputs, structural features from lung segmentation masks, and semantic features from vision-language models (VLMs) for severity quantification. Our approach employs complementary fusion mechanisms that integrate semantic guidance, structural priors, and hierarchical interactions across modalities. The model employs evidential regression to provide both severity predictions and uncertainty estimates. Experiments on the Per-COVID-19 CT and RALO datasets show that TMF-RSE outperforms recent transformer-based baselines, achieving MAE of 4.02 and Pearson correlation of 0.9629 on Per-COVID-19 validation, and 0.339 MAE / 0.973 PC on RALO geographic extent.

Large visual language models (VLMs) have shown strong multi-modal medical reasoning ability, but most operate as end-to-end black boxes, diverging from clinicians' evidence-based, staged workflows and hindering clinical accountability. Complementarily, expert visual grounding models can accurately localize regions of interest (ROIs), providing explicit, reliable evidence that improves both reasoning accuracy and trust. In this paper, we introduce CARE, advancing Clinical Accountability in multi-modal medical Reasoning with an Evidence-grounded agentic framework. Unlike existing approaches that couple grounding and reasoning within a single generalist model, CARE decomposes the task into coordinated sub-modules to reduce shortcut learning and hallucination: a compact VLM proposes relevant medical entities; an expert entity-referring segmentation model produces pixel-level ROI evidence; and a grounded VLM reasons over the full image augmented by ROI hints. The VLMs are optimized with reinforcement learning with verifiable rewards to align answers with supporting evidence. Furthermore, a VLM coordinator plans tool invocation and reviews evidence-answer consistency, providing agentic control and final verification. Evaluated on standard medical VQA benchmarks, our CARE-Flow (coordinator-free) improves average accuracy by 10.9% over the same size (10B) state-of-the-art (SOTA). With dynamic planning and answer review, our CARE-Coord yields a further gain, outperforming the heavily pre-trained SOTA by 5.2%. Our experiments demonstrate that an agentic framework that emulates clinical workflows, incorporating decoupled specialized models and explicit evidence, yields more accurate and accountable medical AI. Project page: https://xypb.github.io/CARE-Project-Page/

Vision-language systems combine images with retrieved text, but these sources can disagree or jointly fail to support an answer. Reliable models must identify the trustworthy source and abstain when neither is adequate. Existing post-training objectives score instances independently and therefore do not enforce coherent behavior under counterfactual evidence changes. We introduce CARGO-VL, a group-relative framework that optimizes matched variants covering aligned, image-correct, text-correct, and both-wrong (A/V/T/N) evidence states as one bundle. Its objective couples condition-wise correctness with transition rewards for answer invariance, source equivariance, and answer-to-abstention switching, while a primal-dual controller balances unsafe answers against excessive deferral. We also contribute XMC (eXtended Modal Conflict), a four-condition conflict training resource, and evaluate transfer on CMC-Bench and Modality-Bias. Across multiple seeds, CARGO-VL improves conflict handling, unsupported-answer avoidance, and modality balance over pointwise baselines. Ablations identify complementary benefits from relational transition signals and adaptive risk control, supporting counterfactual consistency as a practical objective for reliable multimodal evidence arbitration.

LLM agents increasingly answer questions over dynamic raw-document collections, where files may change before preprocessing, and relevant evidence (spans, sections, pages, or tables) is query-dependent. Existing retrieval-augmented approaches pre-materialize evidence via fixed chunking, embeddings, or persistent indexes: effective for lookup, yet costly, stale-prone, and committed to a granularity before the query is known. We formulate in-context search as Budgeted Evidence Localization over a latent evidence space induced by dynamic raw documents and propose LENS (Latent Evidence Exploration and Search), an index-free framework. Instead of pre-materializing the evidence space, LENS maintains a query-conditioned belief over candidate units, iteratively selecting candidates via complementary lexical, local, and exploratory proposal policies, updating the belief via an LLM relevance oracle, and narrowing toward high-posterior regions under a controllable budget. Evidence is consolidated into compact, source-grounded regions of interest and compressed into self-organizing knowledge clusters reused across related queries. On a controlled 500-question evaluation with matched corpus snapshots, LENS reaches 62.4% exact match and 84.8% evidence recall vs. 65.2% exact match but 50.4% evidence recall for a ReAct-style baseline. Across scales, LENS gives the strongest supporting-fact localization and answer grounding. On a fixed 150-question fullwiki subset over the raw Wikipedia dump with zero indexing, LENS and ReAct are nearly tied in official answer quality (43.3% vs. 42.7% EM), with LENS grounding more answers in retrieved evidence (84.0% vs. 70.7%). A no-retrieval Closed-Book reference highlights the contribution of model memory. LENS is query-ready after corpus changes, needs no preprocessing or persistent index, and preserves source-grounded evidence localization throughout.

Deep research agents are increasingly evaluated on their ability to search for evidence, reason over retrieved sources, and produce grounded answers. Existing browsing benchmarks, however, largely assume that the user's query and the supporting evidence are written in the same language, leaving open whether agentic search systems can operate when relevant evidence appears in another language. We introduce XBCP (Cross-lingual BrowseComp-Plus), a controlled benchmark that preserves the English question-and-answer space of BrowseComp-Plus but varies the languages of the supporting documents. XBCP instantiates two complementary settings: in the cross-lingual setting, each query is paired with evidence in a single assigned language. In the multilingual setting, the full evidence corpus is distributed equally and randomly across 12 languages spanning high-resource and low-resource regimes. We evaluate four deep research agents using sparse and dense multilingual retrievers, measuring answer accuracy, evidence recall, search behavior, calibration, citation fidelity, and oracle retrieval. Results reveal substantial degradation when evidence is translated. Even strong, dense retrievers lose evidence recall, and agents become less calibrated and cite evidence less reliably. Notably, accuracy remains lower even when all gold evidence is supplied directly. These findings suggest that cross-lingual deep research exposes both retrieval failures and an independent, agent-side difficulty in integrating language-mismatched evidence.

Misinformation in healthcare, from vaccine hesitancy to unproven treatments, poses risks to public health and trust in medical systems. While machine learning and natural language processing have advanced automated fact-checking, validating biomedical claims remains uniquely challenging due to complex terminology, the need for domain expertise, and the critical importance of grounding in scientific evidence. We introduce CER (Combining Evidence and Reasoning), a novel framework for biomedical fact-checking that integrates scientific evidence retrieval, reasoning via large language models, and supervised veracity prediction. By integrating the text-generation capabilities of large language models with advanced retrieval techniques for high-quality biomedical scientific evidence, CER effectively mitigates the risk of hallucinations, ensuring that generated outputs are grounded in verifiable, evidence-based sources. Evaluations on expert-annotated datasets (HealthFC, BioASQ-7b, SciFact) demonstrate state-of-the-art performance and promising cross-dataset generalization. Code and data are released for transparency and reproducibility: https://github.com/PRAISELab-PicusLab/CER

Evaluating agentic AI on open-ended professional tasks faces a fundamental dilemma between rigor and flexibility. Static rubrics provide rigorous, reproducible assessment but fail to accommodate diverse valid response strategies, while LLM-as-a-judge approaches adapt to individual responses yet suffer from instability and bias. Human experts address this dilemma by combining domain-grounded principles with dynamic, claim-level assessment. Inspired by this process, we propose JADE, a two-layer evaluation framework. Layer 1 encodes expert knowledge as a predefined set of evaluation skills, providing stable evaluation criteria. Layer 2 performs report-specific, claim-level evaluation to flexibly assess diverse reasoning strategies, with evidence-dependency gating to invalidate conclusions built on refuted claims. Experiments on BizBench show that JADE improves evaluation stability and reveals critical agent failure modes missed by holistic LLM-based evaluators. We further demonstrate strong alignment with expert-authored rubrics and effective transfer to a medical-domain benchmark, validating JADE across professional domains. Our code is publicly available at https://github.com/smiling-world/JADE.

Recent advances in large language models have enabled deep research systems that generate expert-level reports through multi-step reasoning and evidence-based synthesis. However, evaluating such reports remains challenging: report quality is multifaceted, making it difficult to determine what to assess and by what criteria; LLM-based judges may miss errors that require domain expertise to identify; and because deep research relies on retrieved evidence, report-wide claim verification is also necessary. To address these issues, we propose DEER, a benchmark for evaluating expert-level deep research reports. DEER systematizes evaluation criteria with an expert-developed taxonomy (7 dimensions, 25 subdimensions) operationalized as 101 fine-grained rubric items. We also provide task-specific Expert Evaluation Guidance to support LLM-based judging. Alongside rubric-based assessment, we propose a claim verification architecture that verifies both cited and uncited claims and quantifies evidence quality. Experiments show that while current deep research systems can produce structurally plausible reports that cite external evidence, there is room for improvement in fulfilling expert-level user requests and achieving logical completeness. Beyond simple performance comparisons, DEER makes system strengths and limitations interpretable and provides diagnostic signals for improvement.

Emerging personal AI agents are moving toward persistent, multi-source memory. This creates an evaluation problem: systems must decide how to use conflicting or incomplete evidence; they cannot just retrieve facts from one clean history. Existing benchmarks rarely show whether an error came from the evidence given to a method or from the method's conflict-resolution step. We study this as selective QA over conflicting multi-source personal memory: systems answer based on conflicting, sometimes incomplete sources, or abstain when evidence is insufficient. We develop a benchmark containing 18 question templates across 8 reasoning types, 480 personas, 4 random seeds, and 34,560 instances, with controlled source distortions and deterministic ground truth. We evaluate the performance of baselines without access to any source, access to a single source, structured fusion methods, and frontier LLMs. The best trained fusion resolver reaches 80.3% accuracy, while the strongest prompt-only LLM baseline reaches 70.0%. With abstention, the same resolver reaches 85.3% selective accuracy at 78.3% coverage and the best LLM reaches 71.0% selective accuracy at 95.4% coverage. Different models have different strengths across reasoning types. We release the data, code, cached model outputs, and data-generating process for reuse.

Incentivizing the reasoning ability of Multimodal Large Language Models (MLLMs) is essential for medical applications to transparently analyze medical scans and provide reliable diagnosis. However, existing medical MLLMs rely solely on internal knowledge during reasoning, leading to hallucinated reasoning and factual inaccuracies when encountering cases beyond their training scope. Although recent Agentic Retrieval-Augmented Generation (RAG) methods elicit the medical model's proactive retrieval ability during reasoning, they are confined to unimodal LLMs, neglecting the crucial visual information during reasoning and retrieval. Consequently, we propose the first Multimodal Medical Reasoning-with-Retrieval framework, Med-RwR, which actively retrieves external knowledge by querying observed symptoms or domain-specific medical concepts during reasoning. Specifically, we design a two-stage reinforcement learning strategy with tailored rewards that stimulate the model to leverage both visual diagnostic findings and textual clinical information for effective retrieval. Building on this foundation, we further propose a Confidence-Driven Image Re-retrieval (CDIR) method for test-time scaling when low prediction confidence is detected. Evaluation on various public medical benchmarks demonstrates Med-RwR's significant improvements over baseline models, proving the effectiveness of enhancing reasoning capabilities with external knowledge integration. Furthermore, Med-RwR demonstrates remarkable generalizability to unfamiliar domains, evidenced by 8.8% performance gain on our proposed EchoCardiography Benchmark (ECBench), despite the scarcity of echocardiography data in the training corpus. Our data, model, and codes will be made publicly available at https://github.com/xmed-lab/Med-RwR.

Constantly evolving real-world knowledge necessitates models to be updated continuously. Especially in medicine, as clinical evidence changes over time, outdated knowledge can pose safety risks. Existing evaluations of knowledge integration focus on factual recall, offering limited insight into whether newly integrated knowledge is actually usable. Our benchmark MedKIT (Medical Knowledge Integration and Transfer) provides a granular evaluation of how models integrate and apply knowledge under realistic sequences of clinical updates. Each instance corresponds to a factual update derived from clinical evidence, paired with targeted probes that assess transfer across lexical variation, relational transformations, compositional reasoning, and open-ended operationalization, as well as locality tests for knowledge preservation. Using MedKIT, we conduct a large-scale empirical study of 12 knowledge integration strategies across 5 diverse models, including both general-purpose and medical LLMs. Our results reveal a consistent gap between recall and usable knowledge: while most methods achieve strong gains on the original update task and under lexical variation, relational generalization is limited, and no method yields meaningful improvements on compositional or operational tasks. These findings highlight a fundamental challenge in knowledge integration and position MedKIT as a testbed for developing methods that make newly integrated knowledge more consistently usable across tasks and contexts.

Large language model (LLM)-based systems are increasingly deployed to conduct scientific research autonomously, yet whether their reasoning adheres to the epistemic norms that make scientific inquiry self-correcting is poorly understood. Here, we evaluate LLM-based scientific agents across eight domains, spanning workflow execution to hypothesis-driven inquiry, through more than 25,000 agent runs and two complementary lenses: (i) a systematic performance analysis that decomposes the contributions of the base model and the agent scaffold, and (ii) a behavioral analysis of the epistemological structure of agent reasoning. We observe that the base model is the primary determinant of both performance and behavior, accounting for 41.4% of explained variance versus 1.5% for the scaffold. Across all configurations, evidence is ignored in 68% of traces, refutation-driven belief revision occurs in 26%, and convergent multi-test evidence is rare. The same reasoning pattern appears whether the agent executes a computational workflow or conducts hypothesis-driven inquiry. They persist even when agents receive near-complete successful reasoning trajectories as context, and the resulting unreliability compounds across repeated trials in epistemically demanding domains. Thus, current LLM-based agents execute scientific workflows but do not exhibit the epistemic patterns that characterize scientific reasoning. Outcome-based evaluation cannot detect these failures, and scaffold engineering alone cannot repair them. Until reasoning itself becomes a training target, the scientific knowledge produced by such agents cannot be justified by the process that generated it.

This position paper argues that AI-assisted software engineering requires explicit mechanisms for tracking the epistemic status and temporal validity of architectural decisions. LLM coding assistants generate decisions faster than teams can validate them, yet no widely-adopted framework distinguishes conjecture from verified knowledge, prevents trust inflation through conservative aggregation, or detects when evidence expires. We propose three requirements for responsible AI-assisted engineering: (1) epistemic layers that separate unverified hypotheses from empirically validated claims, (2) conservative assurance aggregation grounded in the Gödel t-norm that prevents weak evidence from inflating confidence, and (3) automated evidence decay tracking that surfaces stale assumptions before they cause failures. We formalize these requirements as the First Principles Framework (FPF), ground its aggregation semantics in fuzzy logic, and define a quintet of invariants that any valid aggregation operator must satisfy. Our retrospective audit applying FPF criteria to two internal projects found that 20-25% of architectural decisions had stale evidence within two months, validating the need for temporal accountability. We outline research directions including learnable aggregation operators, federated evidence sharing, and SMT-based claim validation.

The growing use of large language models (LLMs) for biomedical question answering raises concerns about the accuracy and evidentiary support of their responses. To address this, we present Answered with Evidence, a framework for evaluating whether LLM-generated answers are grounded in scientific literature. We analyzed thousands of physician-submitted questions using a comparative pipeline that included: (1) Alexandria, fka the Atropos Evidence Library, a retrieval-augmented generation (RAG) system based on novel observational studies, and (2) two PubMed-based retrieval-augmented systems (System and Perplexity). We found that PubMed-based systems provided evidence-supported answers for approximately 44% of questions, while the novel evidence source did so for about 50%. Combined, these sources enabled reliable answers to over 70% of biomedical queries. As LLMs become increasingly capable of summarizing scientific content, maximizing their value will require systems that can accurately retrieve both published and custom-generated evidence or generate such evidence in real time.

As language models shift from single-shot answer generation toward multi-step reasoning that retrieves and consumes evidence mid-inference, evaluating the role of individual retrieved items becomes more important. Existing RAG evaluation typically targets final-answer quality, citation faithfulness, or answer-level attribution, but none of these directly targets the intervention-based, per-evidence-item utility view we study here. We introduce CUE-R, a lightweight intervention-based framework for measuring per-evidence-item operational utility in single-shot RAG using shallow observable retrieval-use traces. CUE-R perturbs individual evidence items via REMOVE, REPLACE, and DUPLICATE operators, then measures changes along three utility axes (correctness, proxy-based grounding faithfulness, and confidence error) plus a trace-divergence signal. We also outline an operational evidence-role taxonomy for interpreting intervention outcomes. Experiments on HotpotQA and 2WikiMultihopQA with Qwen-3 8B and GPT-5.2 reveal a consistent pattern: REMOVE and REPLACE substantially harm correctness and grounding while producing large trace shifts, whereas DUPLICATE is often answer-redundant yet not fully behaviorally neutral. A zero-retrieval control confirms that these effects arise from degradation of meaningful retrieval. A two-support ablation further shows that multi-hop evidence items can interact non-additively: removing both supports harms performance far more than either single removal. Our results suggest that answer-only evaluation misses important evidence effects and that intervention-based utility analysis is a practical complement for RAG evaluation.

Multimodal large language models (MLLMs) have made rapid progress on visual reasoning, yet many tasks require evidence that is difficult to obtain through internal reasoning alone: our controlled study on 22 benchmarks shows that simply increasing the inference budget of the base model yields only modest gains. Such tasks demand grounded perception, external knowledge, and numerical measurements obtained through heterogeneous tools, whose outputs must be made interpretable to the model and retained across reasoning steps. We introduce OpenVLHarness, a multimodal reasoning harness organized around a capability layer and persistent multimodal memory. The capability layer combines task-level tool interfaces with evidence rendering, providing consistent access to heterogeneous backends and converting their outputs into model-readable observations. Persistent multimodal memory retains the corresponding images, structured data, and web references as addressable artifacts throughout each query. A coding interface executes generated programs over stored data, enabling computations that combine results from multiple tools. Together, these mechanisms support an iterative process of acquiring, inspecting, and composing multimodal evidence. Evaluated on 22 benchmarks with eight open and proprietary backbones, OpenVLHarness improves average scores by 9.7-12.6 points over matched no-tool baselines, including +11.2 with Qwen3-VL-8B, +9.7 with Kimi K3, and +9.9 with GPT-6 Astra. With GPT-6 Luna at medium reasoning effort, OpenVLHarness outperforms the base model, Codex, and Visual Sketchpad at maximum effort by 7.7-8.5 points while incurring at most 37% of their model-token cost.

Reinforcement learning with verifiable rewards (RLVR) improves specific capabilities of large language models, but covering multiple capabilities often involves training separate domain experts and subsequently consolidating them. We organize three fusion paradigms by the artefacts they reuse: Merge combines expert task vectors, Mix RL pools their datasets, and multi-teacher on-policy distillation (MOPD) uses both. Because they have largely been studied in isolation, how they compare and how to choose among them remain unclear. We compare all three using shared experts and data across model scales and a multi-domain benchmark suite. Although their average performance differs by at most 1.4 points, the gap reaches 8.6 points on a single benchmark, with domain-level variation tracking cross-domain relations visible in task-vector geometry. Training dynamics expose distinct constraints: Mix RL depends on domain mixture proportions, MOPD remains bounded by its teachers, and Merge compresses all expert updates into one. All three improve single-sample accuracy without measurable gains in solution coverage or losses in held-out capabilities. These results yield a practical guideline: use Merge when experts already exist and cheap fusion is paramount; Mix RL when training a unified model without experts, with domain proportions adjusted for cross-domain transfer; and MOPD when preserving domain-specific gains matters more than surpassing teachers or minimizing end-to-end cost.

AI research often requires decisions before future evidence exists: which bottleneck to attack, which direction to pursue, or where a project should be positioned. We introduce ForeSci, a temporally controlled benchmark for evaluating whether LLM agents can make such forward-looking research judgements from historical evidence. ForeSci contains 500 tasks across four fast-moving AI domains and four decision families. Each task is paired with a cutoff-aligned offline knowledge base; post-cutoff papers are hidden during generation and used only for validation. To avoid random future-event prediction, tasks are derived from pre-cutoff taxonomy branches and evidence signals, and answer-generation backbones are selected to precede the task cutoffs. We evaluate native LLMs, Hybrid RAG, and three research-agent adaptations across four backbones. Results show that explicit evidence organization improves traceability and factual support, but gains depend strongly on the decision family. Diagnostics reveal a recurring evidence-decision decoupling: agents may cite relevant evidence while forecasting the wrong research object. ForeSci turns forward-looking AI research judgement into a controlled benchmark for evaluating research agents as decision-making systems.

While Reinforcement Learning (RL) has advanced LLM reasoning, applying it to long-context scenarios is hindered by sparsity of outcome rewards. This limitation fails to penalize ungrounded "lucky guesses," leaving the critical process of needle-in-a-haystack evidence retrieval largely unsupervised. To address this, we propose EAPO (Evidence-Augmented Policy Optimization). We first establish the Evidence-Augmented Reasoning paradigm, validating via Tree-Structured Evidence Sampling that precise evidence extraction is the decisive bottleneck for long-context reasoning. Guided by this insight, EAPO introduces a specialized RL algorithm where a reward model computes a Group-Relative Evidence Reward, providing dense process supervision to explicitly improve evidence quality. To sustain accurate supervision throughout training, we further incorporate an Adaptive Reward-Policy Co-Evolution mechanism. This mechanism iteratively refines the reward model using outcome-consistent rollouts, sharpening its discriminative capability to ensure precise process guidance. Comprehensive evaluations across eight benchmarks demonstrate that EAPO significantly enhances long-context reasoning performance compared to SOTA baselines.

Medical vision-and-language pre-training (Med-VLP) has received considerable attention owing to its applicability to extracting generic vision-and-language representations from medical images and texts. Most existing methods mainly contain three elements: uni-modal encoders (i.e., a vision encoder and a language encoder), a multi-modal fusion module, and pretext tasks, with few studies considering the importance of medical domain expert knowledge and explicitly exploiting such knowledge to facilitate Med-VLP. Although there exist knowledge-enhanced vision-and-language pre-training (VLP) methods in the general domain, most require off-the-shelf toolkits (e.g., object detectors and scene graph parsers), which are unavailable in the medical domain. In this paper, we propose a systematic and effective approach to enhance Med-VLP by structured medical knowledge from three perspectives. First, considering knowledge can be regarded as the intermediate medium between vision and language, we align the representations of the vision encoder and the language encoder through knowledge. Second, we inject knowledge into the multi-modal fusion model to enable the model to perform reasoning using knowledge as the supplementation of the input image and text. Third, we guide the model to put emphasis on the most critical information in images and texts by designing knowledge-induced pretext tasks. To perform a comprehensive evaluation and facilitate further research, we construct a medical vision-and-language benchmark including three tasks. Experimental results illustrate the effectiveness of our approach, where state-of-the-art performance is achieved on all downstream tasks. Further analyses explore the effects of different components of our approach and various settings of pre-training.

Treatment reasoning underpins every therapeutic decision, integrating disease context, comorbidities, medications, contraindications, and evolving biomedical knowledge to select an appropriate therapy. It is inherently iterative: candidates are weighed against many constraints, revised as evidence emerges, and grounded in verifiable sources. Here we introduce ATHENA-R1, an AI agent for treatment reasoning across all FDA approved drugs since 1939, trained by reinforcement learning over a universe of 212 biomedical tools. At each step it identifies missing information, selects and runs relevant tools, and incorporates the evidence. To train it without human-annotated traces, we build a two-level self-learning framework: multi-agent systems construct the tools, tasks, and reasoning trajectories for supervised fine-tuning, then reinforcement learning with scientific feedback rewards reasoning quality (evidence gathering, grounded tool use, logical non-redundancy). Across five benchmarks of 3,168 drug reasoning tasks and 456 patient treatment cases, ATHENA-R1 outperforms language models and tool-use systems, reaching 94.7% accuracy on open-ended drug reasoning and 82.9% on treatment reasoning, 17.8 and 10.7 points above GPT-5. In blinded evaluations by experts from 28 rare disease organizations, it is preferred over reference models on all criteria, and physicians rated it favorably on complex hospitalized cardiovascular and infectious-disease cases. Adverse-event hypotheses it generated, tested in electronic health records from 5.4 million patients, reached adjusted odds ratios of 1.48-1.84, with no elevation among negative controls. Because it requires knowing what evidence to seek before concluding, treatment reasoning has long been hard for AI; we show it can be reframed as a learnable process of iterative evidence gathering that reinforcement learning can train AI to perform.

Diagnosing 802.11 packet captures requires expert protocol knowledge, is slow, inconsistent across engineers, and unscalable. LLM-based approaches sound plausible but fabricate protocol events absent from captures (especially truncated traces), produce uncalibrated confidence scores, and suffer evaluation bias when golden references are co-produced by the model under test. We introduce PROBE (Protocol Reasoning Over evidence-Based Ensembles), a multi-stage pipeline addressing all three failures. It integrates (i) deterministic PCAP-to-text normalization with frame-level verifiability, (ii) multi-run, multi-candidate ensembles with optional cross-model second opinion and progressive obfuscation, (iii) a verdict-aware evidence framework treating absence of failure evidence as contributing evidence, and (iv) a fully deterministic composite reliability score from evidence validity, run-to-run stability, and cross-model agreement without LLM self-assessment. On 87 enterprise Wi-Fi captures (104 capture-reviewer pairs), single-pass LLM analysis raises weighted evidence F1 from 0.871 (expert baseline) to 0.912 but misses critical frames in 35% of cases. Naive ensemble voting drops below baseline (0.842) as majority voting amplifies conservative verdicts: 50% of confirmed failures are misclassified as 'no issue' or 'insufficient evidence.' Adding evidence-grounded reconciliation achieves 0.957 F1, a 96% auto-accept rate, and a worst-case floor above 0.70. LLM self-reported confidence clusters at 0.95 regardless of difficulty (71% report exactly 0.95), confirming it is uninformative. We also introduce a model-agnostic evaluation framework using per-field assertion matching, eliminating circular bias from model-co-produced golden references.

Retrieval-enhanced methods have become a primary approach in fact verification (FV); it requires reasoning over multiple retrieved pieces of evidence to verify the integrity of a claim. To retrieve evidence, existing work often employs off-the-shelf retrieval models whose design is based on the probability ranking principle. We argue that, rather than relevance, for FV we need to focus on the utility that a claim verifier derives from the retrieved evidence. We introduce the feedback-based evidence retriever(FER) that optimizes the evidence retrieval process by incorporating feedback from the claim verifier. As a feedback signal we use the divergence in utility between how effectively the verifier utilizes the retrieved evidence and the ground-truth evidence to produce the final claim label. Empirical studies demonstrate the superiority of FER over prevailing baselines.

Chest X-ray (CXR) reporting follows a region-based clinical workflow in which radiologists inspect anatomical regions and integrate localized findings into a final report. However, existing resources for CXR report generation provide these supervision signals in fragmented forms. We introduce MMRad-22K, a dataset that organizes regional textual observations, anatomical grounding coordinates, localized image evidence, and report targets into structured multimodal evidence units for CXR report generation. To motivate this formulation, we first compare different evidence formats for report generation and find that structured multimodal evidence is generally more useful than text-only or bounding box-based evidence. We then adapt a unified LVLM backbone using MMRad-22K and show that adaptation with multimodal evidence outperforms both textual-evidence adaptation and end-to-end adaptation on language and clinically oriented metrics. Under the same evaluation protocol, the adapted model also reaches a performance level comparable to several open-source LVLM references. Together, these results support MMRad-22K as a practical structured multimodal resource for training and evaluating CXR report generation aligned with clinical reading workflows.

In image fusion tasks, the absence of real fused images as supervision signals poses significant challenges for supervised learning. Existing deep learning methods typically address this issue either by designing handcrafted priors or by relying on large-scale datasets to learn model parameters. Different from previous approaches, this paper introduces the concept of incomplete priors, which formally describe handcrafted priors at the algorithmic level and estimate their confidence. Based on this idea, we couple incomplete priors with the neural network through a sample-level adaptive loss function, enabling the network to learn and re-infer fusion rules under conditions that approximate the real fusion process.To generate incomplete priors, we propose a Granular Ball Pixel Computation (GBPC) algorithm based on the principles of granular computing. The algorithm models fused-image pixels as information units, estimating pixel weights at a fine-grained level while statistically evaluating prior reliability at a coarse-grained level. This design enables the algorithm to perceive cross-modal discrepancies and perform adaptive inference.Experimental results demonstrate that even under few-shot conditions, a lightweight neural network can still learn effective fusion rules by training only on image patches extracted from ten image pairs. Extensive experiments across multiple fusion tasks and datasets further show that the proposed method achieves superior performance in both visual quality and model compactness. The code is available at: https://github.com/DMinjie/GBFF

RAG (Retrieval-Augmented Generation) systems and web agents are increasingly evaluated on multi-hop deep search tasks, yet current practice suffers from two major limitations. First, most benchmarks leak the reasoning path in the question text, allowing models to follow surface cues rather than discover reasoning chains autonomously. Second, evaluation is typically reduced to a single pass rate, which collapses diverse behaviours into one score and obscures whether failures stem from inadequate search, poor knowledge use, or inappropriate refusal. To address these issues, we present WebDetective, a benchmark of hint-free multi-hop questions paired with a controlled Wikipedia sandbox that ensures full traceability of model actions, and a holistic evaluation framework that separates search sufficiency, knowledge utilisation, and refusal behaviour. Our evaluation of 25 state-of-the-art models reveals systematic weaknesses across all architectures: models struggle with knowledge utilisation despite having sufficient evidence and demonstrate near-absent appropriate refusal when evidence is lacking. These patterns expose a fundamental gap: today's systems excel at executing given reasoning paths but fail when required to discover them. We develop an agentic workflow, EvidenceLoop, that explicitly targets the challenges our benchmark identifies, incorporating verification loops and systematic evidence tracking that improve both search and synthesis capabilities. This baseline demonstrates that WebDetective's diagnostic framework can guide concrete architectural improvements, establishing our benchmark as a critical tool for developing genuinely autonomous reasoning systems rather than pattern-following agents.

Multimodal large language models can expose task-relevant evidence through generation, but producing useful evidence does not by itself determine how it enters a retrieval embedding. We study whether the semantic organization of that evidence can also specify where representations are read. To address this question, we introduce EviAlign, which couples Semantic Evidence Generation with Boundary Readout in a shared multimodal large language model. It organizes evidence into five semantic units, reads the contextualized state at each unit boundary, and aggregates these states into a single normalized embedding. Generation and contrastive retrieval objectives jointly train this shared structure. With the same trailing readout, semantic evidence and free-form CoT yield nearly identical retrieval performance, suggesting that evidence organization alone does not explain the full gain. A controlled 2times3 study compares consistent and permuted evidence organization across three readout strategies, using training targets with matched evidence spans. With five readout states and the same mean pooling, the advantage of consistent semantic organization grows from 0.65 points at length-based training positions to 2.39 at evidence boundaries, yielding a 1.74-point co-design interaction. Across 12 MMEB retrieval tasks, EviAlign achieves 76.9 average Recall@1 with 500K training pairs while retaining single-vector indexing and scoring.

Parameter-efficient adaptation of vision-language foundation models is crucial for precise multimodal understanding of biomedical images, yet existing methods remain deterministic and often struggle under domain shift or ambiguous image-text alignment. This limitation is particularly critical in the clinic, where models should remain robust in low-data regimes and domain shifts. We present Evi-Steer, an evidential cross-modal low-dimensional steering framework for BiomedCLIP that enables uncertainty-aware parameter-efficient fine-tuning while updating only 0.11% of total model parameters. Our approach performs lightweight low-dimensional token updates in both vision and text encoders while simultaneously estimating epistemic uncertainty. These uncertainty estimates update gate residuals, allowing the model to adapt conservatively when evidence is weak. Furthermore, we introduce cross-modal confidence fusion based on Dempster-Shafer theory, enabling visual adaptation to be conditioned on textual confidence and suppressing conflicting or uncertain cross-modal updates. We conduct a comprehensive evaluation on 15 biomedical imaging datasets spanning 8 organs and 8 imaging modalities under few-shot learning and domain generalization settings. Evi-Steer consistently outperforms state-of-the-art methods under few-shot learning and domain shift settings, demonstrating a practical and robust pathway for deploying vision-language models in real-world clinical settings. Code is available at https://github.com/HealthX-Lab/Evi-Steer.

Large language models (LLMs) have shown remarkable promise but remain challenging to continually improve through traditional finetuning, particularly when integrating capabilities from other specialized LLMs. Popular methods like ensemble and weight merging require substantial memory and struggle to adapt to changing data environments. Recent efforts have transferred knowledge from multiple LLMs into a single target model; however, they suffer from interference and degraded performance among tasks, largely due to limited flexibility in candidate selection and training pipelines. To address these issues, we propose a framework that adaptively selects and aggregates knowledge from diverse LLMs to build a single, stronger model, avoiding the high memory overhead of ensemble and inflexible weight merging. Specifically, we design an adaptive selection network that identifies the most relevant source LLMs based on their scores, thereby reducing knowledge interference. We further propose a dynamic weighted fusion strategy that accounts for the inherent strengths of candidate LLMs, along with a feedback-driven loss function that prevents the selector from converging on a single subset of sources. Experimental results demonstrate that our method can enable a more stable and scalable knowledge aggregation process while reducing knowledge interference by up to 50% compared to existing approaches. Code is avaliable at https://github.com/ZLKong/LLM_Integration