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Jul 31

RISED: A Pre-Deployment Evaluation Framework for High-Stakes AI Decision-Support Systems, with Application to Healthcare

Clinical decision-support systems are expert systems whose recommendations clinicians act on directly, yet they are usually cleared on one aggregate accuracy number from a held-out test set. That number says nothing about input reliability under encoding shifts, subgroup gaps, threshold sensitivity, or operational feasibility. We present RISED, a pre-deployment evaluation framework operationalising five dimensions (Reliability, Inclusivity, Sensitivity, Equity, Deployability) through BCa bootstrap 95% confidence intervals, literature-grounded thresholds, and Holm-Bonferroni-corrected PASS / FAIL / INCONCLUSIVE verdicts; Equity is a proxy-dependence diagnostic rather than a gating test. Applied to seven cohorts spanning 35 years (n from 303 to 99,492), RISED surfaces failures invisible to AUROC: on Diabetes 130, Reliability passes by three orders of magnitude (PSS = 0.0004) while Inclusivity (AUC parity gap = 0.262) and Sensitivity (max threshold-flip rate 49.1%) fail decisively; both NHIS cohorts reproduce this. NHANES 2021-2023, with a complete feature profile, achieves INCONCLUSIVE verdicts; BRFSS 2024 produces the suite's most severe Sensitivity failure (max threshold-flip rate 64.2%) after instrument rotation removed hypertension and cholesterol. The pattern recurs on credit- and income-prediction cohorts, confirming domain-agnosticity; a multi-model check shows the failures are data-driven, not model-specific. RISED ships as an open-source Python package complementing TRIPOD+AI, FUTURE-AI, and Fairlearn with the structured numerical evidence those standards require but do not prescribe.

  • 5 authors
·
May 29

Grounded Chess Reasoning in Language Models via Master Distillation

Language models often lack grounded reasoning capabilities in specialized domains where training data is scarce but bespoke systems excel. We introduce a general framework for distilling expert system reasoning into natural language chain-of-thought explanations, enabling compact models to acquire domain expertise and the ability to generate faithful, grounded explanations. Rather than distilling only final outputs, we capture the full reasoning process, transforming opaque expert computations into transparent, step-by-step explanations. We demonstrate this approach in chess, a canonical reasoning domain where language models continue to underperform. Our 4B parameter model, C1, advances from a near-zero baseline to 48.1% accuracy, outperforming all open-source models and most frontier proprietary systems. Notably, C1 surpasses its distillation teacher and generates solutions in two orders of magnitude fewer tokens than baselines. Unlike prior neural chess approaches that predict only best moves, C1 generates explainable solutions revealing strategic reasoning. Our pipeline combines supervised fine-tuning and reinforcement learning with theme-balanced data sampling for comprehensive tactical coverage. Master Distillation demonstrates how to inject expert-level knowledge into compact models for under-optimized domains, offering a recipe for unlocking RLVR where LLMs lack sufficient base capabilities.

  • 7 authors
·
Mar 19

Rare Disease Differential Diagnosis with Large Language Models at Scale: From Abdominal Actinomycosis to Wilson's Disease

Large language models (LLMs) have demonstrated impressive capabilities in disease diagnosis. However, their effectiveness in identifying rarer diseases, which are inherently more challenging to diagnose, remains an open question. Rare disease performance is critical with the increasing use of LLMs in healthcare settings. This is especially true if a primary care physician needs to make a rarer prognosis from only a patient conversation so that they can take the appropriate next step. To that end, several clinical decision support systems are designed to support providers in rare disease identification. Yet their utility is limited due to their lack of knowledge of common disorders and difficulty of use. In this paper, we propose RareScale to combine the knowledge LLMs with expert systems. We use jointly use an expert system and LLM to simulate rare disease chats. This data is used to train a rare disease candidate predictor model. Candidates from this smaller model are then used as additional inputs to black-box LLM to make the final differential diagnosis. Thus, RareScale allows for a balance between rare and common diagnoses. We present results on over 575 rare diseases, beginning with Abdominal Actinomycosis and ending with Wilson's Disease. Our approach significantly improves the baseline performance of black-box LLMs by over 17% in Top-5 accuracy. We also find that our candidate generation performance is high (e.g. 88.8% on gpt-4o generated chats).

  • 3 authors
·
Feb 20, 2025 2

A hybrid deep-learning-metaheuristic framework for bi-level network design problems

This study proposes a hybrid deep-learning-metaheuristic framework with a bi-level architecture for road network design problems (NDPs). We train a graph neural network (GNN) to approximate the solution of the user equilibrium (UE) traffic assignment problem and use inferences made by the trained model to calculate fitness function evaluations of a genetic algorithm (GA) to approximate solutions for NDPs. Using three test networks, two NDP variants and an exact solver as benchmark, we show that on average, our proposed framework can provide solutions within 1.5% gap of the best results in less than 0.5% of the time used by the exact solution procedure. Our framework can be utilized within an expert system for infrastructure planning to determine the best infrastructure planning and management decisions under different scenarios. Given the flexibility of the framework, it can easily be adapted to many other decision problems that can be modeled as bi-level problems on graphs. Moreover, we foreseen interesting future research directions, thus we also put forward a brief research agenda for this topic. The key observation from our research that can shape future research is that the fitness function evaluation time using the inferences made by the GNN model was in the order of milliseconds, which points to an opportunity and a need for novel heuristics that 1) can cope well with noisy fitness function values provided by deep learning models, and 2) can use the significantly enlarged efficiency of the evaluation step to explore the search space effectively (rather than efficiently). This opens a new avenue for a modern class of metaheuristics that are crafted for use with AI-powered predictors.

  • 2 authors
·
Mar 10, 2023

MediQ: Question-Asking LLMs and a Benchmark for Reliable Interactive Clinical Reasoning

Users typically engage with LLMs interactively, yet most existing benchmarks evaluate them in a static, single-turn format, posing reliability concerns in interactive scenarios. We identify a key obstacle towards reliability: LLMs are trained to answer any question, even with incomplete context or insufficient knowledge. In this paper, we propose to change the static paradigm to an interactive one, develop systems that proactively ask questions to gather more information and respond reliably, and introduce an benchmark - MediQ - to evaluate question-asking ability in LLMs. MediQ simulates clinical interactions consisting of a Patient System and an adaptive Expert System; with potentially incomplete initial information, the Expert refrains from making diagnostic decisions when unconfident, and instead elicits missing details via follow-up questions. We provide a pipeline to convert single-turn medical benchmarks into an interactive format. Our results show that directly prompting state-of-the-art LLMs to ask questions degrades performance, indicating that adapting LLMs to proactive information-seeking settings is nontrivial. We experiment with abstention strategies to better estimate model confidence and decide when to ask questions, improving diagnostic accuracy by 22.3%; however, performance still lags compared to an (unrealistic in practice) upper bound with complete information upfront. Further analyses show improved interactive performance with filtering irrelevant contexts and reformatting conversations. Overall, we introduce a novel problem towards LLM reliability, an interactive MediQ benchmark and a novel question-asking system, and highlight directions to extend LLMs' information-seeking abilities in critical domains.

  • 7 authors
·
Jun 2, 2024

OmniAID: Decoupling Semantic and Artifacts for Universal AI-Generated Image Detection in the Wild

A truly universal AI-Generated Image (AIGI) detector must simultaneously generalize across diverse generative models and varied semantic content. Current state-of-the-art methods learn a single, entangled forgery representation, conflating content-dependent flaws with content-agnostic artifacts, and are further constrained by outdated benchmarks. To overcome these limitations, we propose OmniAID, a novel framework centered on a decoupled Mixture-of-Experts (MoE) architecture. The core of our method is a hybrid expert system designed to decouple: (1) semantic flaws across distinct content domains, and (2) content-dependent flaws from content-agnostic universal artifacts. This system employs a set of Routable Specialized Semantic Experts, each for a distinct domain (e.g., human, animal), complemented by a Fixed Universal Artifact Expert. This architecture is trained using a novel two-stage strategy: we first train the experts independently with domain-specific hard-sampling to ensure specialization, and subsequently train a lightweight gating network for effective input routing. By explicitly decoupling "what is generated" (content-specific flaws) from "how it is generated" (universal artifacts), OmniAID achieves robust generalization. To address outdated benchmarks and validate real-world applicability, we introduce Mirage, a new large-scale, contemporary dataset. Extensive experiments, using both traditional benchmarks and our Mirage dataset, demonstrate our model surpasses existing monolithic detectors, establishing a new and robust standard for AIGI authentication against modern, in-the-wild threats.

  • 7 authors
·
Nov 11, 2025 1

Agentic ERP: Multi-Agent Large Language Model Architecture for Autonomous Enterprise Resource Planning

Enterprise Resource Planning (ERP) systems record transactions reliably but still delegate almost all operational decision-making to human specialists, because classical rule-based automation cannot reason about exceptions and monolithic AI assistants degrade when asked to coordinate across functional boundaries. This paper presents Agentic ERP, an expert-system architecture that combines role-aligned large-language-model (LLM) agents with a risk-tiered human-in-the-loop harness and a graph-based orchestrator to execute end-to-end business workflows on a production ERP backend. First, autonomous ERP operation is formulated as a constrained sequential-decision problem over a structured enterprise state, with a decomposition argument linking role-aligned agents to a measurable reduction in per-step tool-selection complexity. Second, a graph-based Planner--Executor--Reflector--Responder orchestration decouples generation from evaluation through externalised grading criteria and sprint contracts, packaging recent harness-engineering principles as inspectable expert-system artefacts. Third, the system is evaluated at three levels: a scenario-based task suite, a comprehensive comparison of six orchestration paradigms on cross-functional crisis tasks, and a 365-day agent-in-the-loop simulation against rule-based RPA and no-intervention baselines. Across these levels the proposed multi-agent method is significantly better than the baseline, and the system sustains a simulated year of operation with zero stockouts while the rule-based baseline accumulates hundreds under the same demand stream. The work shows that role-aligned LLM agents under human oversight can move an ERP system from passively recording transactions to actively executing operational decisions, and it provides a reference architecture and an evaluation protocol for autonomous enterprise resource planning.

  • 4 authors
·
Jul 18

Intelligent Design 4.0: Paradigm Evolution Toward the Agentic AI Era

Research and practice in Intelligent Design (ID) have significantly enhanced engineering innovation, efficiency, quality, and productivity over recent decades, fundamentally reshaping how engineering designers think, behave, and interact with design processes. The recent emergence of Foundation Models (FMs), particularly Large Language Models (LLMs), has demonstrated general knowledge-based reasoning capabilities, and open new paths and avenues for further transformation in engineering design. In this context, this paper introduces Intelligent Design 4.0 (ID 4.0) as an emerging paradigm empowered by agentic AI systems. We review the historical evolution of ID across four distinct stages: rule-based expert systems, task-specific machine learning models, large-scale foundation AI models, and the recent emerging paradigm of multi-agent collaboration. We propose a conceptual framework for ID 4.0 and discuss its potential to support end-to-end automation of engineering design processes through coordinated, autonomous multi-agent-based systems. Furthermore, we discuss future perspectives to enhance and fully realize ID 4.0's potential, including more complex design scenarios, more practical design implementations, novel agent coordination mechanisms, and autonomous design goal-setting with better human value alignment. In sum, these insights lay a foundation for advancing Intelligent Design toward greater adaptivity, autonomy, and effectiveness in addressing increasingly complex design challenges.

  • 5 authors
·
Jun 11, 2025

Training Vision-Language-Action Models with Dense Embodied Chain-of-Thought Supervision

Cross-embodiment transfer in vision-language-action (VLA) models remains challenging because low-level state and action spaces differ fundamentally across robot platforms. We observe that the high-level cognitive process underlying manipulation, including scene perception, object identification, task planning, and sub-task decomposition, is largely shared across embodiments. Based on this observation, we present ZR-0, a 2.6 billion parameter end-to-end VLA model that uses dense Embodied Chain-of-Thought (ECoT) supervision to align cross-embodiment representations within the vision-language model (VLM). ZR-0 adopts a dual-stream architecture: a pre-trained VLM (System 2) generates structured ECoT reasoning during training, while a Diffusion Transformer-based action expert (System 1) produces continuous action chunks via flow matching. The two components are coupled through cross-attention, with an attention mask that restricts the action expert to input prompt features only, enabling ECoT generation to be entirely skipped at inference without any performance loss. ZR-0 is pre-trained on ProcCorpus-60M, a large-scale dataset comprising approximately 60 million frames (approximately 1,000 hours) from over 400K trajectories, with dense ECoT annotations covering 96.8% of all frames. We evaluate ZR-0 on three simulation benchmarks spanning single-arm (LIBERO), bimanual (RoboTwin 2.0), and humanoid (RoboCasa GR-1 Tabletop) embodiments, as well as real-world experiments on the xArm platform, demonstrating strong performance across all settings. Code and model checkpoints are available at https://github.com/RUCKBReasoning/ZR-0.

  • 12 authors
·
Jun 30

BoxMind: Closed-loop AI strategy optimization for elite boxing validated in the 2024 Olympics

Competitive sports require sophisticated tactical analysis, yet combat disciplines like boxing remain underdeveloped in AI-driven analytics due to the complexity of action dynamics and the lack of structured tactical representations. To address this, we present BoxMind, a closed-loop AI expert system validated in elite boxing competition. By defining atomic punch events with precise temporal boundaries and spatial and technical attributes, we parse match footage into 18 hierarchical technical-tactical indicators. We then propose a graph-based predictive model that fuses these explicit technical-tactical profiles with learnable, time-variant latent embeddings to capture the dynamics of boxer matchups. Modeling match outcome as a differentiable function of technical-tactical indicators, we turn winning probability gradients into executable tactical adjustments. Experiments show that the outcome prediction model achieves state-of-the-art performance, with 69.8% accuracy on BoxerGraph test set and 87.5% on Olympic matches. Using this predictive model as a foundation, the system generates strategic recommendations that demonstrate proficiency comparable to human experts. BoxMind is validated through a closed-loop deployment during the 2024 Paris Olympics, directly contributing to the Chinese National Team's historic achievement of three gold and two silver medals. BoxMind establishes a replicable paradigm for transforming unstructured video data into strategic intelligence, bridging the gap between computer vision and decision support in competitive sports.

  • 11 authors
·
Jan 16

Bridging Handheld and Teleoperated Supervision for Contact-Rich Manipulation via State-Gated Experts

Handheld data collection systems, such as the Universal Manipulation Interface (UMI), enable scalable data collection across diverse environments but only capture observed actions rather than the desired actions executed by a robot controller. In contrast, teleoperation captures desired actions directly, but is prohibitively time-consuming to collect. We revisit this trade-off through the lens of action validity across task phases. We observe that handheld trajectories provide valid supervision in tolerant, free-space phases, but lack dynamic feasibility in contact-sensitive phases, where tracking observed trajectories at high stiffness produces large, unsafe contact forces. We study the interaction between these two supervision types for contact-rich manipulation and find that training policies that combine handheld data with a small number of targeted teleoperated demonstrations provide an efficient hybrid strategy. Specifically, rather than teleoperating the entire task, we only collect partial teleoperated demonstrations for task segments where base handheld policies fail. However, naively mixing handheld and teleoperated phase-specific data yields worse performance than training on handheld data alone. To address this mismatch between observed and desired supervision, we propose Bi-modal Routing for Imitation Data via Gated Experts (BRIDGE), a mixture of diffusion policy experts that routes between specialist task phase heads conditioned on the current robot state. Notably, our approach enables task-phase specific use of desired actions during contact sensitive segments and improves success rates over handheld-only baselines by up to 36.7% across three contact-rich manipulation tasks.

  • 3 authors
·
Jun 24

Annotated History of Modern AI and Deep Learning

Machine learning is the science of credit assignment: finding patterns in observations that predict the consequences of actions and help to improve future performance. Credit assignment is also required for human understanding of how the world works, not only for individuals navigating daily life, but also for academic professionals like historians who interpret the present in light of past events. Here I focus on the history of modern artificial intelligence (AI) which is dominated by artificial neural networks (NNs) and deep learning, both conceptually closer to the old field of cybernetics than to what's been called AI since 1956 (e.g., expert systems and logic programming). A modern history of AI will emphasize breakthroughs outside of the focus of traditional AI text books, in particular, mathematical foundations of today's NNs such as the chain rule (1676), the first NNs (linear regression, circa 1800), and the first working deep learners (1965-). From the perspective of 2022, I provide a timeline of the -- in hindsight -- most important relevant events in the history of NNs, deep learning, AI, computer science, and mathematics in general, crediting those who laid foundations of the field. The text contains numerous hyperlinks to relevant overview sites from my AI Blog. It supplements my previous deep learning survey (2015) which provides hundreds of additional references. Finally, to round it off, I'll put things in a broader historic context spanning the time since the Big Bang until when the universe will be many times older than it is now.

  • 1 authors
·
Dec 21, 2022

Autonomous Multi-Modal LLM Agents for Treatment Planning in Focused Ultrasound Ablation Surgery

Focused Ultrasound Ablation Surgery (FUAS) has emerged as a promising non-invasive therapeutic modality, valued for its safety and precision. Nevertheless, its clinical implementation entails intricate tasks such as multimodal image interpretation, personalized dose planning, and real-time intraoperative decision-making processes that demand intelligent assistance to improve efficiency and reliability. We introduce FUAS-Agents, an autonomous agent system that leverages the multimodal understanding and tool-using capabilities of large language models (LLMs). By integrating patient profiles and MRI data, FUAS-Agents orchestrates a suite of specialized medical AI tools, including segmentation, treatment dose prediction, and clinical guideline retrieval, to generate personalized treatment plans comprising MRI image, dose parameters, and therapeutic strategies. We evaluate the system in a uterine fibroid treatment scenario. Human assessment by four senior FUAS experts indicates that 82.5%, 82.5%, 87.5%, and 97.5% of the generated plans were rated 4 or above (on a 5-point scale) in terms of completeness, accuracy, fluency, and clinical compliance, respectively. These results demonstrate the potential of LLM-driven agents in enhancing decision-making across complex clinical workflows, and exemplify a translational paradigm that combines general-purpose models with specialized expert systems to solve practical challenges in vertical healthcare domains.

  • 9 authors
·
May 27, 2025

Digestion Algorithm in Hierarchical Symbolic Forests: A Fast Text Normalization Algorithm and Semantic Parsing Framework for Specific Scenarios and Lightweight Deployment

Text Normalization and Semantic Parsing have numerous applications in natural language processing, such as natural language programming, paraphrasing, data augmentation, constructing expert systems, text matching, and more. Despite the prominent achievements of deep learning in Large Language Models (LLMs), the interpretability of neural network architectures is still poor, which affects their credibility and hence limits the deployments of risk-sensitive scenarios. In certain scenario-specific domains with scarce data, rapidly obtaining a large number of supervised learning labels is challenging, and the workload of manually labeling data would be enormous. Catastrophic forgetting in neural networks further leads to low data utilization rates. In situations where swift responses are vital, the density of the model makes local deployment difficult and the response time long, which is not conducive to local applications of these fields. Inspired by the multiplication rule, a principle of combinatorial mathematics, and human thinking patterns, a multilayer framework along with its algorithm, the Digestion Algorithm in Hierarchical Symbolic Forests (DAHSF), is proposed to address these above issues, combining text normalization and semantic parsing workflows. The Chinese Scripting Language "Fire Bunny Intelligent Development Platform V2.0" is an important test and application of the technology discussed in this paper. DAHSF can run locally in scenario-specific domains on little datasets, with model size and memory usage optimized by at least two orders of magnitude, thus improving the execution speed, and possessing a promising optimization outlook.

  • 1 authors
·
Dec 18, 2024

Pelican-Unified 1.0: A Unified Embodied Intelligence Model for Understanding, Reasoning, Imagination and Action

We present Pelican-Unified 1.0, the first embodied foundation model trained according to the principle of unification. Pelican-Unified 1.0 uses a single VLM as a unified understanding module, mapping scenes, instructions, visual contexts, and action histories into a shared semantic space. The same VLM also serves as a unified reasoning module, autoregressively producing task-, action-, and future-oriented chains of thought in a single forward pass and projecting the final hidden state into a dense latent variable. A Unified Future Generator (UFG) then conditions on this latent variable and jointly generates future videos and future actions through two modality-specific output heads within the same denoising process. The language, video, and action losses are all backpropagated into the shared representation, enabling the model to jointly optimize understanding, reasoning, imagination, and action during training, rather than training three isolated expert systems. Experiments demonstrate that unification does not imply compromise. With a single checkpoint, Pelican-Unified 1.0 achieves strong performance across all three capabilities: 64.7 on eight VLM benchmarks, the best among comparable-scale models; 66.03 on WorldArena, ranking first; and 93.5 on RoboTwin, the second-best average among compared action methods. These results show that the unified paradigm succeeds in preserving specialist strength while bringing understanding, reasoning, imagination, and action into one model.

  • 27 authors
·
May 13

HOBBIT: A Mixed Precision Expert Offloading System for Fast MoE Inference

The Mixture-of-Experts (MoE) architecture has demonstrated significant advantages in the era of Large Language Models (LLMs), offering enhanced capabilities with reduced inference costs. However, deploying MoE-based LLMs on memoryconstrained edge devices remains challenging due to their substantial memory requirements. While existing expertoffloading methods alleviate the memory requirements, they often incur significant expert-loading costs or compromise model accuracy. We present HOBBIT, a mixed precision expert offloading system to enable flexible and efficient MoE inference. Our key insight is that dynamically replacing less critical cache-miss experts with low precision versions can substantially reduce expert-loading latency while preserving model accuracy. HOBBIT introduces three innovative techniques that map the natural hierarchy of MoE computation: (1) a token-level dynamic expert loading mechanism, (2) a layer-level adaptive expert prefetching technique, and (3) a sequence-level multidimensional expert caching policy. These innovations fully leverage the benefits of mixedprecision expert inference. By implementing HOBBIT on top of the renowned LLM inference framework Llama.cpp, we evaluate its performance across different edge devices with representative MoE models. The results demonstrate that HOBBIT achieves up to a 9.93x speedup in decoding compared to state-of-the-art MoE offloading systems.

  • 8 authors
·
Nov 3, 2024

Rethinking Retrieval-Augmented Generation for Medicine: A Large-Scale, Systematic Expert Evaluation and Practical Insights

Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented generation (RAG) has been widely adopted to address these limitations by supplementing model outputs with retrieved evidence. However, whether RAG reliably achieves these goals remains unclear. Here, we present the most comprehensive expert evaluation of RAG in medicine to date. Eighteen medical experts contributed a total of 80,502 annotations, assessing 800 model outputs generated by GPT-4o and Llama-3.1-8B across 200 real-world patient and USMLE-style queries. We systematically decomposed the RAG pipeline into three components: (i) evidence retrieval (relevance of retrieved passages), (ii) evidence selection (accuracy of evidence usage), and (iii) response generation (factuality and completeness of outputs). Contrary to expectation, standard RAG often degraded performance: only 22% of top-16 passages were relevant, evidence selection remained weak (precision 41-43%, recall 27-49%), and factuality and completeness dropped by up to 6% and 5%, respectively, compared with non-RAG variants. Retrieval and evidence selection remain key failure points for the model, contributing to the overall performance drop. We further show that simple yet effective strategies, including evidence filtering and query reformulation, substantially mitigate these issues, improving performance on MedMCQA and MedXpertQA by up to 12% and 8.2%, respectively. These findings call for re-examining RAG's role in medicine and highlight the importance of stage-aware evaluation and deliberate system design for reliable medical LLM applications.

  • 27 authors
·
Nov 10, 2025

SubgoalXL: Subgoal-based Expert Learning for Theorem Proving

Formal theorem proving, a field at the intersection of mathematics and computer science, has seen renewed interest with advancements in large language models (LLMs). This paper introduces SubgoalXL, a novel approach that synergizes subgoal-based proofs with expert learning to enhance LLMs' capabilities in formal theorem proving within the Isabelle environment. SubgoalXL addresses two critical challenges: the scarcity of specialized mathematics and theorem-proving data, and the need for improved multi-step reasoning abilities in LLMs. By optimizing data efficiency and employing subgoal-level supervision, SubgoalXL extracts richer information from limited human-generated proofs. The framework integrates subgoal-oriented proof strategies with an expert learning system, iteratively refining formal statement, proof, and subgoal generators. Leveraging the Isabelle environment's advantages in subgoal-based proofs, SubgoalXL achieves a new state-of-the-art performance of 56.1\% in Isabelle on the standard miniF2F dataset, marking an absolute improvement of 4.9\%. Notably, SubgoalXL successfully solves 41 AMC12, 9 AIME, and 3 IMO problems from miniF2F. These results underscore the effectiveness of maximizing limited data utility and employing targeted guidance for complex reasoning in formal theorem proving, contributing to the ongoing advancement of AI reasoning capabilities. The implementation is available at https://github.com/zhaoxlpku/SubgoalXL.

  • 6 authors
·
Aug 20, 2024

MedSkillAudit: A Domain-Specific Audit Framework for Medical Research Agent Skills

Background: Agent skills are increasingly deployed as modular, reusable capability units in AI agent systems. Medical research agent skills require safeguards beyond general-purpose evaluation, including scientific integrity, methodological validity, reproducibility, and boundary safety. This study developed and preliminarily evaluated a domain-specific audit framework for medical research agent skills, with a focus on reliability against expert review. Methods: We developed MedSkillAudit (skill-auditor@1.0), a layered framework assessing skill release readiness before deployment. We evaluated 75 skills across five medical research categories (15 per category). Two experts independently assigned a quality score (0-100), an ordinal release disposition (Production Ready / Limited Release / Beta Only / Reject), and a high-risk failure flag. System-expert agreement was quantified using ICC(2,1) and linearly weighted Cohen's kappa, benchmarked against the human inter-rater baseline. Results: The mean consensus quality score was 72.4 (SD = 13.0); 57.3% of skills fell below the Limited Release threshold. MedSkillAudit achieved ICC(2,1) = 0.449 (95% CI: 0.250-0.610), exceeding the human inter-rater ICC of 0.300. System-consensus score divergence (SD = 9.5) was smaller than inter-expert divergence (SD = 12.4), with no directional bias (Wilcoxon p = 0.613). Protocol Design showed the strongest category-level agreement (ICC = 0.551); Academic Writing showed a negative ICC (-0.567), reflecting a structural rubric-expert mismatch. Conclusions: Domain-specific pre-deployment audit may provide a practical foundation for governing medical research agent skills, complementing general-purpose quality checks with structured audit workflows tailored to scientific use cases.

AIPOCH-AI AIPOCH
·
Apr 21 2

Periodical embeddings uncover hidden interdisciplinary patterns in the subject classification scheme of science

Subject classification schemes are foundational to the organization, evaluation, and navigation of scientific knowledge. While expert-curated systems like Scopus provide widely used taxonomies, they often suffer from coarse granularity, subjectivity, and limited adaptability to emerging interdisciplinary fields. Data-driven alternatives based on citation networks show promise but lack rigorous, external validation against the semantic content of scientific literature. Here, we propose a novel quantitative framework that leverages classification tasks to evaluate the effectiveness of journal classification schemes. Using over 23 million paper abstracts, we demonstrate that labels derived from k-means clustering on Periodical2Vec (P2V)--a periodical embedding learned from paper-level citations--yield significantly higher classification performance than both Scopus and other data-driven baselines (e.g., citation, co-citation, and Node2Vec variants). By comparing journal partitions across classification schemes, two structural patterns emerge on the map of science: (1) the reorganization of disciplinary boundaries--splitting overly broad categories (e.g., "Medicine" into "Oncology", "Cardiology", and other specialties) while merging artificially fragmented ones (e.g., "Chemistry" and "Chemical Engineering"); and (2) the identification of coherent interdisciplinary clusters--such as "Biomedical Engineering", "Medical Ethics", and "Information Management"--that are dispersed across multiple categories but unified in citation space. These findings underscore that citation-derived periodical embeddings not only outperform traditional taxonomies in predictive validity but also offer a dynamic, fine-grained map of science that better reflects both the specialization and interdisciplinarity inherent in contemporary research.

  • 2 authors
·
Dec 27, 2025

Leveraging Open Knowledge for Advancing Task Expertise in Large Language Models

The cultivation of expertise for large language models (LLMs) to solve tasks of specific areas often requires special-purpose tuning with calibrated behaviors on the expected stable outputs. To avoid huge cost brought by manual preparation of instruction datasets and training resources up to hundreds of hours, the exploitation of open knowledge including a wealth of low rank adaptation (LoRA) models and instruction datasets serves as a good starting point. However, existing methods on model and data selection focus on the performance of general-purpose capabilities while neglecting the knowledge gap exposed in domain-specific deployment. In the present study, we propose to bridge such gap by introducing few human-annotated samples (i.e., K-shot) for advancing task expertise of LLMs with open knowledge. Specifically, we develop an efficient and scalable pipeline to cost-efficiently produce task experts where K-shot data intervene in selecting the most promising expert candidates and the task-relevant instructions. A mixture-of-expert (MoE) system is built to make the best use of individual-yet-complementary knowledge between multiple experts. We unveil the two keys to the success of a MoE system, 1) the abidance by K-shot, and 2) the insistence on diversity. For the former, we ensure that models that truly possess problem-solving abilities on K-shot are selected rather than those blind guessers. Besides, during data selection, instructions that share task-relevant contexts with K-shot are prioritized. For the latter, we highlight the diversity of constituting experts and that of the fine-tuning instructions throughout the model and data selection process. Extensive experimental results confirm the superiority of our approach over existing methods on utilization of open knowledge across various tasks. Codes and models will be released later.

  • 12 authors
·
Aug 28, 2024 4

Sparse Mixture-of-Experts Routing in Visual Diffusion Transformers:Diagnosis, Boundary Calibration and Evolutionary Roadmap from Routing Collapse to Selective Deadlock

This paper systematically diagnoses the training failure modes of Token-Choice sparse Mixture-of-Experts (MoE) on video Diffusion Transformers. Starting from a pretrained dense model of about 5 billion parameters, we convert it into an MoE architecture following three laws: routed experts exactly clone the original FFN weights, shared experts are initialized to zero for verification and then to extremely small non-zero noise for actual training, while only the gating networks start from random initialization. Experiments reveal a hierarchy of five failure modes: (1) linear routers suffer global soft saturation with complete expert homogenization; (2) MLP routers introduce selective deadlock, where roughly one-third of layers degenerate into a single-expert mode that cannot be prevented by increasing the auxiliary loss; (3) cross-attention routers exhibit preliminary self-recovery, yet about nine layers remain stubbornly deadlocked; (4) deadlocked layers display a U-shaped distribution, concentrated in shallow visual processing layers and deep semantic integration layers; (5) bfloat16 mixed precision causes tiny weight updates to be truncated to zero by hardware. Based on routing decision time series over 65 million tokens across 5,000 training steps, we propose the Functional Redundancy Hypothesis: deadlock is a rational waiting strategy before the shared expert matures within the gate-shared expert-routed expert triadic system. This hypothesis is supported by the theory of functional redundancy in systems biology. On the engineering side, we summarize the Three Laws of dense-to-MoE conversion and provide a complete solution for the bfloat16 precision trap. We calibrate the current capability boundary of the Token-Choice paradigm and outline a three-step evolutionary roadmap from visual unification to a world model.

  • 1 authors
·
May 11

Not All Models Suit Expert Offloading: On Local Routing Consistency of Mixture-of-Expert Models

Mixture-of-Experts (MoE) enables efficient scaling of large language models (LLMs) with sparsely activated experts during inference. To effectively deploy large MoE models on memory-constrained devices, many systems introduce *expert offloading* that caches a subset of experts in fast memory, leaving others on slow memory to run on CPU or load on demand. While some research has exploited the locality of expert activations, where consecutive tokens activate similar experts, the degree of this **local routing consistency** varies across models and remains understudied. In this paper, we propose two metrics to measure local routing consistency of MoE models: (1) **Segment Routing Best Performance (SRP)**, which evaluates how well a fixed group of experts can cover the needs of a segment of tokens, and (2) **Segment Cache Best Hit Rate (SCH)**, which measures the optimal segment-level cache hit rate under a given cache size limit. We analyzed 20 MoE LLMs with diverse sizes and architectures and found that models that apply MoE on every layer and do not use shared experts exhibit the highest local routing consistency. We further showed that domain-specialized experts contribute more to routing consistency than vocabulary-specialized ones, and that most models can balance between cache effectiveness and efficiency with cache sizes approximately 2x the active experts. These findings pave the way for memory-efficient MoE design and deployment without compromising inference speed. We publish the code for replicating experiments at https://github.com/ljcleo/moe-lrc .

  • 6 authors
·
May 21, 2025 2

Reliable Fine-Grained Evaluation of Natural Language Math Proofs

Recent advances in large language models (LLMs) for mathematical reasoning have largely focused on tasks with easily verifiable final answers; however, generating and verifying natural language math proofs remains an open challenge. We identify the absence of a reliable, fine-grained evaluator for LLM-generated math proofs as a critical gap. To address this, we propose a systematic methodology for developing and validating evaluators that assign fine-grained scores on a 0-7 scale to model-generated math proofs. To enable this study, we introduce ProofBench, the first expert-annotated dataset of fine-grained proof ratings, spanning 145 problems from six major math competitions (USAMO, IMO, Putnam, etc) and 435 LLM-generated solutions from Gemini-2.5-pro, o3, and DeepSeek-R1. %with expert gradings. Using ProofBench as a testbed, we systematically explore the evaluator design space across key axes: the backbone model, input context, instructions and evaluation workflow. Our analysis delivers ProofGrader, an evaluator that combines a strong reasoning backbone LM, rich context from reference solutions and marking schemes, and a simple ensembling method; it achieves a low Mean Absolute Error (MAE) of 0.926 against expert scores, significantly outperforming naive baselines. Finally, we demonstrate its practical utility in a best-of-n selection task: at n=16, ProofGrader achieves an average score of 4.14 (out of 7), closing 78% of the gap between a naive binary evaluator (2.48) and the human oracle (4.62), highlighting its potential to advance downstream proof generation.

  • 9 authors
·
Oct 13, 2025

Beyond Standard MoE: Mixture of Latent Experts for Resource-Efficient Language Models

Mixture of Experts (MoE) has emerged as a pivotal architectural paradigm for efficient scaling of Large Language Models (LLMs), operating through selective activation of parameter subsets for each input token. Nevertheless, conventional MoE architectures encounter substantial challenges, including excessive memory utilization and communication overhead during training and inference, primarily attributable to the proliferation of expert modules. In this paper, we introduce Mixture of Latent Experts (MoLE), a novel parameterization methodology that facilitates the mapping of specific experts into a shared latent space. Specifically, all expert operations are systematically decomposed into two principal components: a shared projection into a lower-dimensional latent space, followed by expert-specific transformations with significantly reduced parametric complexity. This factorized approach substantially diminishes parameter count and computational requirements. Beyond the pretraining implementation of the MoLE architecture, we also establish a rigorous mathematical framework for transforming pre-trained MoE models into the MoLE architecture, characterizing the sufficient conditions for optimal factorization and developing a systematic two-phase algorithm for this conversion process. Our comprehensive theoretical analysis demonstrates that MoLE significantly enhances computational efficiency across multiple dimensions while preserving model representational capacity. Empirical evaluations corroborate our theoretical findings, confirming that MoLE achieves performance comparable to standard MoE implementations while substantially reducing resource requirements.

  • 7 authors
·
Mar 29, 2025

AI-Driven Scholarly Peer Review via Persistent Workflow Prompting, Meta-Prompting, and Meta-Reasoning

Critical peer review of scientific manuscripts presents a significant challenge for Large Language Models (LLMs), partly due to data limitations and the complexity of expert reasoning. This report introduces Persistent Workflow Prompting (PWP), a potentially broadly applicable prompt engineering methodology designed to bridge this gap using standard LLM chat interfaces (zero-code, no APIs). We present a proof-of-concept PWP prompt for the critical analysis of experimental chemistry manuscripts, featuring a hierarchical, modular architecture (structured via Markdown) that defines detailed analysis workflows. We develop this PWP prompt through iterative application of meta-prompting techniques and meta-reasoning aimed at systematically codifying expert review workflows, including tacit knowledge. Submitted once at the start of a session, this PWP prompt equips the LLM with persistent workflows triggered by subsequent queries, guiding modern reasoning LLMs through systematic, multimodal evaluations. Demonstrations show the PWP-guided LLM identifying major methodological flaws in a test case while mitigating LLM input bias and performing complex tasks, including distinguishing claims from evidence, integrating text/photo/figure analysis to infer parameters, executing quantitative feasibility checks, comparing estimates against claims, and assessing a priori plausibility. To ensure transparency and facilitate replication, we provide full prompts, detailed demonstration analyses, and logs of interactive chats as supplementary resources. Beyond the specific application, this work offers insights into the meta-development process itself, highlighting the potential of PWP, informed by detailed workflow formalization, to enable sophisticated analysis using readily available LLMs for complex scientific tasks.

  • 1 authors
·
May 6, 2025 2

MuQ-Eval: An Open-Source Per-Sample Quality Metric for AI Music Generation Evaluation

Distributional metrics such as Fréchet Audio Distance cannot score individual music clips and correlate poorly with human judgments, while the only per-sample learned metric achieving high human correlation is closed-source. We introduce MUQ-EVAL, an open-source per-sample quality metric for AIgenerated music built by training lightweight prediction heads on frozen MuQ-310M features using MusicEval, a dataset of generated clips from 31 text-to-music systems with expert quality ratings. Our simplest model, frozen features with attention pooling and a two-layer MLP, achieves system-level SRCC = 0.957 and utterance-level SRCC = 0.838 with human mean opinion scores. A systematic ablation over training objectives and adaptation strategies shows that no addition meaningfully improves the frozen baseline, indicating that frozen MuQ representations already capture quality-relevant information. Encoder choice is the dominant design factor, outweighing all architectural and training decisions. LoRA-adapted models trained on as few as 150 clips already achieve usable correlation, enabling personalized quality evaluators from individual listener annotations. A controlled degradation analysis reveals selective sensitivity to signal-level artifacts but insensitivity to musical-structural distortions. Our metric, MUQ-EVAL, is fully open-source, outperforms existing open per-sample metrics, and runs in real time on a single consumer GPU. Code, model weights, and evaluation scripts are available at https://github.com/dgtql/MuQ-Eval.

  • 2 authors
·
Mar 23

Transitive Expert Error and Routing Problems in Complex AI Systems

Domain expertise enhances judgment within boundaries but creates systematic vulnerabilities specifically at borders. We term this Transitive Expert Error (TEE), distinct from Dunning-Kruger effects, requiring calibrated expertise as precondition. Mechanisms enabling reliable within-domain judgment become liabilities when structural similarity masks causal divergence. Two core mechanisms operate: structural similarity bias causes experts to overweight surface features (shared vocabulary, patterns, formal structure) while missing causal architecture differences; authority persistence maintains confidence across competence boundaries through social reinforcement and metacognitive failures (experts experience no subjective uncertainty as pattern recognition operates smoothly on familiar-seeming inputs.) These mechanism intensify under three conditions: shared vocabulary masking divergent processes, social pressure for immediate judgment, and delayed feedback. These findings extend to AI routing architectures (MoE systems, multi-model orchestration, tool-using agents, RAG systems) exhibiting routing-induced failures (wrong specialist selected) and coverage-induced failures (no appropriate specialist exists). Both produce a hallucination phenotype: confident, coherent, structurally plausible but causally incorrect outputs at domain boundaries. In human systems where mechanisms are cognitive black boxes; AI architectures make them explicit and addressable. We propose interventions: multi-expert activation with disagreement detection (router level), boundary-aware calibration (specialist level), and coverage gap detection (training level). TEE has detectable signatures (routing patterns, confidence-accuracy dissociations, domain-inappropriate content) enabling monitoring and mitigation. What remains intractable in human cognition becomes addressable through architectural design.

  • 1 authors
·
Jan 6

MemLoRA: Distilling Expert Adapters for On-Device Memory Systems

Memory-augmented Large Language Models (LLMs) have demonstrated remarkable consistency during prolonged dialogues by storing relevant memories and incorporating them as context. Such memory-based personalization is also key in on-device settings that allow users to keep their conversations and data private. However, memory-augmented systems typically rely on LLMs that are too costly for local on-device deployment. Even though Small Language Models (SLMs) are more suitable for on-device inference than LLMs, they cannot achieve sufficient performance. Additionally, these LLM-based systems lack native visual capabilities, limiting their applicability in multimodal contexts. In this paper, we introduce (i) MemLoRA, a novel memory system that enables local deployment by equipping SLMs with specialized memory adapters, and (ii) its vision extension MemLoRA-V, which integrates small Vision-Language Models (SVLMs) to memory systems, enabling native visual understanding. Following knowledge distillation principles, each adapter is trained separately for specific memory operationsx2013knowledge extraction, memory update, and memory-augmented generation. Equipped with memory adapters, small models enable accurate on-device memory operations without cloud dependency. On text-only operations, MemLoRA outperforms 10times larger baseline models (e.g., Gemma2-27B) and achieves performance comparable to 60times larger models (e.g., GPT-OSS-120B) on the LoCoMo benchmark. To evaluate visual understanding operations instead, we extend LoCoMo with challenging Visual Question Answering tasks that require direct visual reasoning. On this, our VLM-integrated MemLoRA-V shows massive improvements over caption-based approaches (81.3 vs. 23.7 accuracy) while keeping strong performance in text-based tasks, demonstrating the efficacy of our method in multimodal contexts.

  • 6 authors
·
Dec 4, 2025 1

Pre-gated MoE: An Algorithm-System Co-Design for Fast and Scalable Mixture-of-Expert Inference

Large language models (LLMs) based on transformers have made significant strides in recent years, the success of which is driven by scaling up their model size. Despite their high algorithmic performance, the computational and memory requirements of LLMs present unprecedented challenges. To tackle the high compute requirements of LLMs, the Mixture-of-Experts (MoE) architecture was introduced which is able to scale its model size without proportionally scaling up its computational requirements. Unfortunately, MoE's high memory demands and dynamic activation of sparse experts restrict its applicability to real-world problems. Previous solutions that offload MoE's memory-hungry expert parameters to CPU memory fall short because the latency to migrate activated experts from CPU to GPU incurs high performance overhead. Our proposed Pre-gated MoE system effectively tackles the compute and memory challenges of conventional MoE architectures using our algorithm-system co-design. Pre-gated MoE employs our novel pre-gating function which alleviates the dynamic nature of sparse expert activation, allowing our proposed system to address the large memory footprint of MoEs while also achieving high performance. We demonstrate that Pre-gated MoE is able to improve performance, reduce GPU memory consumption, while also maintaining the same level of model quality. These features allow our Pre-gated MoE system to cost-effectively deploy large-scale LLMs using just a single GPU with high performance.

  • 8 authors
·
Aug 23, 2023

When Does Sparsity Mitigate the Curse of Depth in LLMs

Recent work has demonstrated the curse of depth in large language models (LLMs), where later layers contribute less to learning and representation than earlier layers. Such under-utilization is linked to the accumulated growth of variance in Pre-Layer Normalization, which can push deep blocks toward near-identity behavior. In this paper, we demonstrate that, sparsity, beyond enabling efficiency, acts as a regulator of variance propagation and thereby improves depth utilization. Our investigation covers two sources of sparsity: (i) implicit sparsity, which emerges from training and data conditions, including weight sparsity induced by weight decay and attention sparsity induced by long context inputs; and (ii) explicit sparsity, which is enforced by architectural design, including key/value-sharing sparsity in Grouped-Query Attention and expert-activation sparsity in Mixtureof-Experts. Our claim is thoroughly supported by controlled depth-scaling experiments and targeted layer effectiveness interventions. Across settings, we observe a consistent relationship: sparsity improves layer utilization by reducing output variance and promoting functional differentiation. We eventually distill our findings into a practical rule-of-thumb recipe for training deptheffective LLMs, yielding a notable 4.6% accuracy improvement on downstream tasks. Our results reveal sparsity, arising naturally from standard design choices, as a key yet previously overlooked mechanism for effective depth scaling in LLMs. Code is available at https://github.com/pUmpKin-Co/SparsityAndCoD.

SSKG Hub: An Expert-Guided Platform for LLM-Empowered Sustainability Standards Knowledge Graphs

Sustainability disclosure standards (e.g., GRI, SASB, TCFD, IFRS S2) are comprehensive yet lengthy, terminology-dense, and highly cross-referential, hindering structured analysis and downstream use. We present SSKG Hub (Sustainability Standards Knowledge Graph Hub), a research prototype and interactive web platform that transforms standards into auditable knowledge graphs (KGs) through an LLM-centered, expert-guided pipeline. The system integrates automatic standard identification, configurable chunking, standard-specific prompting, robust triple parsing, and provenance-aware Neo4j storage with fine-grained audit metadata. LLM extraction produces a provenance-linked Draft KG, which is reviewed, curated, and formally promoted to a Certified KG through meta-expert adjudication. A role-based governance framework covering read-only guest access, expert review and CRUD operations, meta-expert certification, and administrative oversight ensures traceability and accountability across draft and certified states. Beyond graph exploration and triple-level evidence tracing, SSKG Hub supports cross-KG fusion, KG-driven tasks, and dedicated modules for insights and curated resources. We validate the platform through a comprehensive expert-led KG review case study that demonstrates end-to-end curation and quality assurance. The web application is publicly available at www.sskg-hub.com.

  • 13 authors
·
Feb 27

TRUST: An LLM-Based Dialogue System for Trauma Understanding and Structured Assessments

Objectives: While Large Language Models (LLMs) have been widely used to assist clinicians and support patients, no existing work has explored dialogue systems for standard diagnostic interviews and assessments. This study aims to bridge the gap in mental healthcare accessibility by developing an LLM-powered dialogue system that replicates clinician behavior. Materials and Methods: We introduce TRUST, a framework of cooperative LLM modules capable of conducting formal diagnostic interviews and assessments for Post-Traumatic Stress Disorder (PTSD). To guide the generation of appropriate clinical responses, we propose a Dialogue Acts schema specifically designed for clinical interviews. Additionally, we develop a patient simulation approach based on real-life interview transcripts to replace time-consuming and costly manual testing by clinicians. Results: A comprehensive set of evaluation metrics is designed to assess the dialogue system from both the agent and patient simulation perspectives. Expert evaluations by conversation and clinical specialists show that TRUST performs comparably to real-life clinical interviews. Discussion: Our system performs at the level of average clinicians, with room for future enhancements in communication styles and response appropriateness. Conclusions: Our TRUST framework shows its potential to facilitate mental healthcare availability.

  • 4 authors
·
Apr 30, 2025

Bridging Expert Knowledge and Automated Feature Engineering via Self-Evolution

In high-stakes settings such as brand compliance, clinical care, and content moderation, machine learning cannot be deployed as opaque oracles: practitioners inspect the features driving model decisions, and models must leverage the expert documentation governing these domains. In practice, the data arrives as unstructured content, and features extracted from it must be interpretable, discriminative, and aligned with what experts consider important. Existing methods fall short: they target tabular inputs, lack demonstrated expert alignment, and cannot operationalize qualitative criteria such as 'maintain professional tone' into precise features. We present FEST (Feature Engineering with Self-evolving Trees), combining dual-stream feature generation (semantic and deterministic), semantic deduplication, and tree-guided iterative evolution to discover auditable features from raw text and images. FEST leads in 17 of 20 classifier-task combinations across brand classification, content authenticity detection, and stress detection, with a mean gain of 4.2 pp over the strongest baseline across five classifiers. An LLM-as-judge evaluation shows FEST achieves 60-80% coverage of expert-designed brand features at strict semantic-alignment thresholds, corroborated by a human expert study rating features highly on relevance, clarity, and actionability. When seeded with expert guidelines, FEST refines qualitative criteria into operational features, improving accuracy by 6-12 pp on average across brands. To enable systematic evaluation of expert alignment in automated feature engineering, we release BrandGuide, the first dataset pairing expert-designed features with 1M+ assets across 2,683 brands. By grounding feature engineering in expert knowledge, FEST opens a practical pathway for interpretable ML in domains demanding human oversight.

  • 6 authors
·
Jun 6

COLLEAGUE.SKILL: Automated AI Skill Generation via Expert Knowledge Distillation

LLM agents are increasingly expected not only to complete isolated tasks, but also to carry bounded representations of human expertise, judgment, and interaction style. Building such person-grounded agents remains difficult because actionable knowledge associated with a person or role is usually embedded in heterogeneous traces rather than written as clean instructions. Existing memory and persona systems capture fragments of this evidence, while skill frameworks provide portable packaging formats; however, there is no end-to-end workflow for distilling these traces into inspectable, correctable, and agent-usable skills. We present an automated trace-to-skill distillation system for generating person-grounded AI skills via expert knowledge distillation. Given materials from a target person or role, COLLEAGUE.SKILL produces a versioned skill package with two coordinated tracks: a capability track for practices, mental models, and decision heuristics, and a bounded behavior track for communication style, interaction rules, and correction history. The package can be inspected, invoked, updated through natural-language feedback, rolled back, installed across agent hosts, and optionally prepared for controlled distribution. We describe the artifact contract, generation workflow, correction lifecycle, deployment surface, and domain presets implemented in the open-source system. At the time of writing, the public repository has approximately 18.5k GitHub stars; the gallery lists 215 skills from 165 contributors and more than 100k cumulative stars across listed skill cards. The system illustrates how person-grounded skills can be represented as portable, correctable packages rather than opaque prompts or hidden memories.

Towards Expert-Level Medical Question Answering with Large Language Models

Recent artificial intelligence (AI) systems have reached milestones in "grand challenges" ranging from Go to protein-folding. The capability to retrieve medical knowledge, reason over it, and answer medical questions comparably to physicians has long been viewed as one such grand challenge. Large language models (LLMs) have catalyzed significant progress in medical question answering; Med-PaLM was the first model to exceed a "passing" score in US Medical Licensing Examination (USMLE) style questions with a score of 67.2% on the MedQA dataset. However, this and other prior work suggested significant room for improvement, especially when models' answers were compared to clinicians' answers. Here we present Med-PaLM 2, which bridges these gaps by leveraging a combination of base LLM improvements (PaLM 2), medical domain finetuning, and prompting strategies including a novel ensemble refinement approach. Med-PaLM 2 scored up to 86.5% on the MedQA dataset, improving upon Med-PaLM by over 19% and setting a new state-of-the-art. We also observed performance approaching or exceeding state-of-the-art across MedMCQA, PubMedQA, and MMLU clinical topics datasets. We performed detailed human evaluations on long-form questions along multiple axes relevant to clinical applications. In pairwise comparative ranking of 1066 consumer medical questions, physicians preferred Med-PaLM 2 answers to those produced by physicians on eight of nine axes pertaining to clinical utility (p < 0.001). We also observed significant improvements compared to Med-PaLM on every evaluation axis (p < 0.001) on newly introduced datasets of 240 long-form "adversarial" questions to probe LLM limitations. While further studies are necessary to validate the efficacy of these models in real-world settings, these results highlight rapid progress towards physician-level performance in medical question answering.

  • 31 authors
·
May 16, 2023 2

DEER: A Benchmark for Evaluating Deep Research Agents on Expert Report Generation

Recent advances in large language models have enabled deep research systems that generate expert-level reports through multi-step reasoning and evidence-based synthesis. However, evaluating such reports remains challenging: report quality is multifaceted, making it difficult to determine what to assess and by what criteria; LLM-based judges may miss errors that require domain expertise to identify; and because deep research relies on retrieved evidence, report-wide claim verification is also necessary. To address these issues, we propose DEER, a benchmark for evaluating expert-level deep research reports. DEER systematizes evaluation criteria with an expert-developed taxonomy (7 dimensions, 25 subdimensions) operationalized as 101 fine-grained rubric items. We also provide task-specific Expert Evaluation Guidance to support LLM-based judging. Alongside rubric-based assessment, we propose a claim verification architecture that verifies both cited and uncited claims and quantifies evidence quality. Experiments show that while current deep research systems can produce structurally plausible reports that cite external evidence, there is room for improvement in fulfilling expert-level user requests and achieving logical completeness. Beyond simple performance comparisons, DEER makes system strengths and limitations interpretable and provides diagnostic signals for improvement.

LG-AI-Research LG AI Research
·
Dec 19, 2025 1

Expert Personas Improve LLM Alignment but Damage Accuracy: Bootstrapping Intent-Based Persona Routing with PRISM

Persona prompting can steer LLM generation towards a domain-specific tone and pattern. This behavior enables use cases in multi-agent systems where diverse interactions are crucial and human-centered tasks require high-level human alignment. Prior works provide mixed opinions on their utility: some report performance gains when using expert personas for certain domains and their contribution to data diversity in synthetic data creation, while others find near-zero or negative impact on general utility. To fully leverage the benefits of the LLM persona and avoid its harmfulness, a more comprehensive investigation of the mechanism is crucial. In this work, we study how model optimization, task type, prompt length, and placement can impact expert persona effectiveness across instruction-tuned and reasoning LLMs, and provide insight into conditions under which expert personas fail and succeed. Based on our findings, we developed a pipeline to fully leverage the benefits of an expert persona, named PRISM (Persona Routing via Intent-based Self-Modeling), which self-distills an intent-conditioned expert persona into a gated LoRA adapter through a bootstrapping process that requires no external data, models, or knowledge. PRISM enhances human preference and safety alignment on generative tasks while maintaining accuracy on discriminative tasks across all models, with minimal memory and computing overhead.

  • 3 authors
·
Mar 18

VerifyBench: A Systematic Benchmark for Evaluating Reasoning Verifiers Across Domains

Large language models (LLMs) increasingly rely on reinforcement learning (RL) to enhance their reasoning capabilities through feedback. A critical challenge is verifying the consistency of model-generated responses and reference answers, since these responses are often lengthy, diverse, and nuanced. Rule-based verifiers struggle with complexity, prompting the use of model-based verifiers. However, specialized verifiers lack flexibility, while general LLM judges can be inconsistent. Existing research primarily focuses on building better verifiers, yet a systematic evaluation of different types of verifiers' performance across domains remains lacking, severely constraining the reliable development of Reinforcement Learning with Verifiable Reward (RLVR). To address this, we propose VerifyBench--a cross-domain comprehensive benchmark for systematically evaluating verifiers. We construct 4,000 expert-level questions covering mathematics, physics, chemistry, and biology. Each question is equipped with reference answers and diverse responses. The reliability of the evaluation is ensured through a rigorous annotation process conducted by a multidisciplinary expert team. We design a four-dimensional experimental framework to comprehensively compare the performance boundaries of specialized verifiers and general LLMs under combined conditions of extracted answers vs. complete responses, and short vs. long outputs. Our evaluation uncovers fundamental trade-offs in verifiers: while specialized verifiers achieve leading accuracy, they exhibit deficiencies in recall; general models show stronger inclusivity but unstable precision. More importantly, we discover verifiers' high sensitivity to input structure and inherent limitations in cross-domain generalization, providing critical insights into the bottlenecks of current verifier technology.

  • 5 authors
·
Jul 13, 2025

RMA: an Agentic System for Research-Level Mathematical Problems

We present Research Math Agents (RMA), an agentic framework for automated reasoning on research-level mathematical problems. Unlike prior studies centered on competition mathematics or formal theorem proving, RMA targets research-level mathematical problems that require long-horizon reasoning, literature grounding, and iterative proof refinement. RMA decomposes research-level proof solving into specialized modules for problem analysis, literature search and understanding, fair comparison, knowledge-bank construction, and proof verification, all coordinated by initializer, proposer, and verifier agents through a shared structured memory. Within this unified framework, these agents operate in a multi-role, multi-round workflow, collaboratively generating, refining, and verifying candidate proofs through iterative feedback. We evaluate RMA on the First Proof benchmark, which consists of ten research-level problems contributed by expert mathematicians across diverse domains. Through comprehensive expert evaluation, RMA outperforms strong baselines on the First Proof benchmark, including GPT-5.2R and Aletheia, solving eight out of ten research problems and producing more logically sound and readable proofs. Our comprehensive ablation studies further show that performance gains arise from the interaction of structured reasoning modules, iterative refinement, and verifier-based feedback, rather than any single component. Our solutions and implementations will be made publicly available upon acceptance.

  • 4 authors
·
May 19

LEMONADE: A Large Multilingual Expert-Annotated Abstractive Event Dataset for the Real World

This paper presents LEMONADE, a large-scale conflict event dataset comprising 39,786 events across 20 languages and 171 countries, with extensive coverage of region-specific entities. LEMONADE is based on a partially reannotated subset of the Armed Conflict Location & Event Data (ACLED), which has documented global conflict events for over a decade. To address the challenge of aggregating multilingual sources for global event analysis, we introduce abstractive event extraction (AEE) and its subtask, abstractive entity linking (AEL). Unlike conventional span-based event extraction, our approach detects event arguments and entities through holistic document understanding and normalizes them across the multilingual dataset. We evaluate various large language models (LLMs) on these tasks, adapt existing zero-shot event extraction systems, and benchmark supervised models. Additionally, we introduce ZEST, a novel zero-shot retrieval-based system for AEL. Our best zero-shot system achieves an end-to-end F1 score of 58.3%, with LLMs outperforming specialized event extraction models such as GoLLIE. For entity linking, ZEST achieves an F1 score of 45.7%, significantly surpassing OneNet, a state-of-the-art zero-shot baseline that achieves only 23.7%. However, these zero-shot results lag behind the best supervised systems by 20.1% and 37.0% in the end-to-end and AEL tasks, respectively, highlighting the need for further research.

  • 9 authors
·
Jun 1, 2025

LABIIUM: AI-Enhanced Zero-configuration Measurement Automation System

The complexity of laboratory environments requires solutions that simplify instrument interaction and enhance measurement automation. Traditional tools often require configuration, software, and programming skills, creating barriers to productivity. Previous approaches, including dedicated software suites and custom scripts, frequently fall short in providing user-friendly solutions that align with programming practices. We present LABIIUM, an AI-enhanced, zero-configuration measurement automation system designed to streamline experimental workflows and improve user productivity. LABIIUM integrates an AI assistant powered by Large Language Models (LLMs) to generate code. LABIIUM's Lab-Automation-Measurement Bridges (LAMBs) enable seamless instrument connectivity using standard tools such as VSCode and Python, eliminating setup overhead. To demonstrate its capabilities, we conducted experiments involving the measurement of the parametric transfer curve of a simple two-transistor inverting amplifier with a current source load. The AI assistant was evaluated using different prompt scenarios and compared with multiple models, including Claude Sonnet 3.5, Gemini Pro 1.5, and GPT-4o. An expert solution implementing the Gradient-Weighted Adaptive Stochastic Sampling (GWASS) method was used as a baseline. The solutions generated by the AI assistant were compared with the expert solution and a uniform linear sweep baseline with 10,000 points. The graph results show that the LLMs were able to successfully complete the most basic uniform sweep, but LLMs were unable to develop adaptive sweeping algorithms to compete with GWASS. The evaluation underscores LABIIUM's ability to enhance laboratory productivity and support digital transformation in research and industry, and emphasizes the future work required to improve LLM performance in Electronic Measurement Science Tasks.

  • 2 authors
·
Dec 6, 2024

ExpertFlow: Optimized Expert Activation and Token Allocation for Efficient Mixture-of-Experts Inference

Sparse Mixture of Experts (MoE) models, while outperforming dense Large Language Models (LLMs) in terms of performance, face significant deployment challenges during inference due to their high memory demands. Existing offloading techniques, which involve swapping activated and idle experts between the GPU and CPU, often suffer from rigid expert caching mechanisms. These mechanisms fail to adapt to dynamic routing, leading to inefficient cache utilization, or incur prohibitive costs for prediction training. To tackle these inference-specific challenges, we introduce ExpertFlow, a comprehensive system specifically designed to enhance inference efficiency by accommodating flexible routing and enabling efficient expert scheduling between CPU and GPU. This reduces overhead and boosts system performance. Central to our approach is a predictive routing path-based offloading mechanism that utilizes a lightweight predictor to accurately forecast routing paths before computation begins. This proactive strategy allows for real-time error correction in expert caching, significantly increasing cache hit ratios and reducing the frequency of expert transfers, thereby minimizing I/O overhead. Additionally, we implement a dynamic token scheduling strategy that optimizes MoE inference by rearranging input tokens across different batches. This method not only reduces the number of activated experts per batch but also improves computational efficiency. Our extensive experiments demonstrate that ExpertFlow achieves up to 93.72\% GPU memory savings and enhances inference speed by 2 to 10 times compared to baseline methods, highlighting its effectiveness and utility as a robust solution for resource-constrained inference scenarios.

  • 10 authors
·
Oct 23, 2024

Evaluating AI systems under uncertain ground truth: a case study in dermatology

For safety, medical AI systems undergo thorough evaluations before deployment, validating their predictions against a ground truth which is assumed to be fixed and certain. However, this ground truth is often curated in the form of differential diagnoses. While a single differential diagnosis reflects the uncertainty in one expert assessment, multiple experts introduce another layer of uncertainty through disagreement. Both forms of uncertainty are ignored in standard evaluation which aggregates these differential diagnoses to a single label. In this paper, we show that ignoring uncertainty leads to overly optimistic estimates of model performance, therefore underestimating risk associated with particular diagnostic decisions. To this end, we propose a statistical aggregation approach, where we infer a distribution on probabilities of underlying medical condition candidates themselves, based on observed annotations. This formulation naturally accounts for the potential disagreements between different experts, as well as uncertainty stemming from individual differential diagnoses, capturing the entire ground truth uncertainty. Our approach boils down to generating multiple samples of medical condition probabilities, then evaluating and averaging performance metrics based on these sampled probabilities. In skin condition classification, we find that a large portion of the dataset exhibits significant ground truth uncertainty and standard evaluation severely over-estimates performance without providing uncertainty estimates. In contrast, our framework provides uncertainty estimates on common metrics of interest such as top-k accuracy and average overlap, showing that performance can change multiple percentage points. We conclude that, while assuming a crisp ground truth can be acceptable for many AI applications, a more nuanced evaluation protocol should be utilized in medical diagnosis.

  • 20 authors
·
Jul 5, 2023

A Mixture-of-Expert Approach to RL-based Dialogue Management

Despite recent advancements in language models (LMs), their application to dialogue management (DM) problems and ability to carry on rich conversations remain a challenge. We use reinforcement learning (RL) to develop a dialogue agent that avoids being short-sighted (outputting generic utterances) and maximizes overall user satisfaction. Most existing RL approaches to DM train the agent at the word-level, and thus, have to deal with a combinatorially complex action space even for a medium-size vocabulary. As a result, they struggle to produce a successful and engaging dialogue even if they are warm-started with a pre-trained LM. To address this issue, we develop a RL-based DM using a novel mixture of expert language model (MoE-LM) that consists of (i) a LM capable of learning diverse semantics for conversation histories, (ii) a number of {\em specialized} LMs (or experts) capable of generating utterances corresponding to a particular attribute or personality, and (iii) a RL-based DM that performs dialogue planning with the utterances generated by the experts. Our MoE approach provides greater flexibility to generate sensible utterances with different intents and allows RL to focus on conversational-level DM. We compare it with SOTA baselines on open-domain dialogues and demonstrate its effectiveness both in terms of the diversity and sensibility of the generated utterances and the overall DM performance.

  • 6 authors
·
May 31, 2022

MergePipe: A Budget-Aware Parameter Management System for Scalable LLM Merging

Large language model (LLM) merging has become a key technique in modern LLM development pipelines, enabling the integration of multiple task- or domain-specific expert models without retraining. However, as the number of experts grows, existing merging implementations treat model parameters as unstructured files and execute merges in a stateless, one-shot manner, leading to excessive disk I/O, redundant parameter scans, and poor scalability. In this paper, we present MergePipe, a parameter management system for scalable LLM merging. MergePipe is the first system that treats LLM merging as a data management and execution problem, and introduces a catalog-driven abstraction over model parameters, merge plans, and execution lineage. At its core, MergePipe employs a cost-aware planner that explicitly models expert parameter I/O and enforces user-specified I/O budgets, followed by a streaming execution engine that materializes merged models under transactional guarantees. Our key insight is that while base model reads and output writes are unavoidable, expert parameter reads dominate merge cost and constitute the primary optimization target. By making expert access budget-aware throughout planning and execution, MergePipe mitigates the O(K) I/O growth of naive pipelines and achieves predictable scaling behavior. Experiments show that MergePipe reduces total I/O by up to an order of magnitude and delivers up to 11times end-to-end speedups (up to 90\% wall-time reduction) over state-of-the-art LLM merging pipelines.

  • 9 authors
·
Feb 4

GraphMASAL: A Graph-based Multi-Agent System for Adaptive Learning

The advent of Intelligent Tutoring Systems (ITSs) has marked a paradigm shift in education, enabling highly personalized learning pathways. However, true personalization requires adapting to learners' complex knowledge states (multi-source) and diverse goals (multi-sink); existing ITSs often lack the necessary structural-reasoning capability and knowledge dynamism to generate genuinely effective learning paths, and they lack scientifically rigorous validation paradigms. In this paper we propose GraphMASAL (A Graph-based Multi-Agent System for Adaptive Learning), which integrates (i) a dynamic knowledge graph for persistent, stateful learner modeling; (ii) a LangGraph-orchestrated trio of agents (Diagnostician, Planner, Tutor); (iii) a knowledge-graph-grounded two-stage neural IR component (dual-encoder dense retrieval with cross-encoder listwise re-ranking and calibrated score fusion); and (iv) a multi-source multi-sink (MSMS) planning engine with a cognitively grounded cost and an approximation guarantee via greedy set cover. Under blinded automated evaluations with matched inputs and inference settings across diverse student profiles, GraphMASAL consistently outperforms LLM prompting and structured ablations in planning--achieving stronger structural/sequence alignment of learning paths, higher coverage of weak concepts, and lower learning cost--while also surpassing prompt-based baselines in cognitive diagnosis. Agreement with expert/LLM-proxy ratings further supports the validity of our evaluation protocol. These findings indicate that grounding LLM agents in a dynamic knowledge graph, coupled with optimization under educational constraints, yields reliable, interpretable, and pedagogically plausible learning plans, advancing personalized and goal-oriented education.

  • 3 authors
·
Nov 14, 2025

Accurate Expert Predictions in MoE Inference via Cross-Layer Gate

Large Language Models (LLMs) have demonstrated impressive performance across various tasks, and their application in edge scenarios has attracted significant attention. However, sparse-activated Mixture-of-Experts (MoE) models, which are well suited for edge scenarios, have received relatively little attention due to their high memory demands. Offload-based methods have been proposed to address this challenge, but they face difficulties with expert prediction. Inaccurate expert predictions can result in prolonged inference delays. To promote the application of MoE models in edge scenarios, we propose Fate, an offloading system designed for MoE models to enable efficient inference in resource-constrained environments. The key insight behind Fate is that gate inputs from adjacent layers can be effectively used for expert prefetching, achieving high prediction accuracy without additional GPU overhead. Furthermore, Fate employs a shallow-favoring expert caching strategy that increases the expert hit rate to 99\%. Additionally, Fate integrates tailored quantization strategies for cache optimization and IO efficiency. Experimental results show that, compared to Load on Demand and Expert Activation Path-based method, Fate achieves up to 4.5x and 1.9x speedups in prefill speed and up to 4.1x and 2.2x speedups in decoding speed, respectively, while maintaining inference quality. Moreover, Fate's performance improvements are scalable across different memory budgets.

  • 8 authors
·
Feb 17, 2025

MedPMC: A Systematic Framework for Scaling High-Fidelity Medical Multimodal Data for Foundation Models

Medicine is inherently multimodal, requiring clinicians to synthesize information across diverse data streams. Yet the development of multimodal foundation models is constrained by limited access to large-scale, high-quality clinical data. Although PubMed Central (PMC) offers a complementary source of expert-authored image-text data, existing PMC-derived resources remain limited in fidelity, reproducibility, and clinical validation. We introduce MedPMC, an automated, continuously updatable framework that transforms permissively licensed literature into high-fidelity infrastructure for medical multimodal models. Applied to 6.1 million PMC articles, MedPMC curated 11 million medical image-text pairs. Component evaluations showed strong performance for initial screening (F1 = 93.2), multi-panel figure detection (F1 = 96.5), figure separation (mAP = 89.8), caption separation and alignment (F1 = 81.4; ROUGE-L = 85.3), and medical figure classification (F1 = 96.5). Manual review by five annotators, three with medical training, found 95.3% of MedPMC images medically relevant, versus 19.7% in a prior PMC-derived dataset. Across 26 benchmarks spanning 11 specialties, a MedPMC-trained CLIP-style model improved average zero-shot AUC by 7.1 percentage points over the strongest architecture-matched biomedical CLIP baseline despite using fewer than half as many image-text pairs. As the vision encoder in a multimodal large language model, it improved medical visual question-answering by 1.9 and 16.9 percentage points across two benchmarks. In 10,524 Yale New Haven Health System dermatology photographs, it improved morphology-to-image retrieval Recall@5 by 11.7 percentage points. These findings show that high-fidelity literature curation strengthens medical multimodal foundation models across benchmark and clinical settings. We publicly release the framework, corpus, benchmarks, and pretrained models.

SlimMoE: Structured Compression of Large MoE Models via Expert Slimming and Distillation

The Mixture of Experts (MoE) architecture has emerged as a powerful paradigm for scaling large language models (LLMs) while maintaining inference efficiency. However, their enormous memory requirements make them prohibitively expensive to fine-tune or deploy in resource-constrained environments. To address this challenge, we introduce SlimMoE, a multi-stage compression framework for transforming large MoE models into much smaller, efficient variants without incurring the prohibitive costs of training from scratch. Our method systematically reduces parameter counts by slimming experts and transferring knowledge through intermediate stages, effectively mitigating the performance degradation common in one-shot pruning approaches. Using this framework, we compress Phi 3.5-MoE (41.9B total/6.6B activated parameters) to create Phi-mini-MoE (7.6B total/2.4B activated parameters) and Phi-tiny-MoE (3.8B total/1.1B activated parameters) using only 400B tokens--less than 10% of the original model's training data. These compressed models can be fine-tuned on a single GPU (A100 for Phi-mini-MoE, A6000 for Phi-tiny-MoE), making them highly suitable for academic and resource-limited settings. Our experiments demonstrate that these compressed models outperform others of similar size and remain competitive with larger models. For instance, Phi-mini-MoE achieves similar or better performance to Phi-3-mini using only 2/3 of the activated parameters and yields comparable MMLU scores to Llama 3.1 8B despite having significantly lower latency. Our findings demonstrate that structured pruning combined with staged distillation offers an effective path to creating high-quality, compact MoE models, paving the way for broader adoption of MoE architectures. We make our models publicly available at https://huggingface.co/microsoft/Phi-mini-MoE-instruct and https://huggingface.co/microsoft/Phi-tiny-MoE-instruct .

  • 7 authors
·
Jun 23, 2025 2

Xpertbench: Expert Level Tasks with Rubrics-Based Evaluation

As Large Language Models (LLMs) exhibit plateauing performance on conventional benchmarks, a pivotal challenge persists: evaluating their proficiency in complex, open-ended tasks characterizing genuine expert-level cognition. Existing frameworks suffer from narrow domain coverage, reliance on generalist tasks, or self-evaluation biases. To bridge this gap, we present XpertBench, a high-fidelity benchmark engineered to assess LLMs across authentic professional domains. XpertBench consists of 1,346 meticulously curated tasks across 80 categories, spanning finance, healthcare, legal services, education, and dual-track research (STEM and Humanities). These tasks are derived from over 1,000 submissions by domain experts--including researchers from elite institutions and practitioners with extensive clinical or industrial experience--ensuring superior ecological validity. Each task uses detailed rubrics with mostly 15-40 weighted checkpoints to assess professional rigor. To facilitate scalable yet human-aligned assessment, we introduce ShotJudge, a novel evaluation paradigm that employs LLM judges calibrated with expert few-shot exemplars to mitigate self-rewarding biases. Our empirical evaluation of state-of-the-art LLMs reveals a pronounced performance ceiling: even leading models achieve a peak success rate of only ~66%, with a mean score around 55%. Models also exhibit domain-specific divergence, showing non-overlapping strengths in quantitative reasoning versus linguistic synthesis.. These findings underscore a significant "expert-gap" in current AI systems and establish XpertBench as a critical instrument for navigating the transition from general-purpose assistants to specialized professional collaborators.

  • 31 authors
·
Mar 26 1

DeepResearch Bench II: Diagnosing Deep Research Agents via Rubrics from Expert Report

Deep Research Systems (DRS) aim to help users search the web, synthesize information, and deliver comprehensive investigative reports. However, how to rigorously evaluate these systems remains under-explored. Existing deep-research benchmarks often fall into two failure modes. Some do not adequately test a system's ability to analyze evidence and write coherent reports. Others rely on evaluation criteria that are either overly coarse or directly defined by LLMs (or both), leading to scores that can be biased relative to human experts and are hard to verify or interpret. To address these issues, we introduce Deep Research Bench II, a new benchmark for evaluating DRS-generated reports. It contains 132 grounded research tasks across 22 domains; for each task, a system must produce a long-form research report that is evaluated by a set of 9430 fine-grained binary rubrics in total, covering three dimensions: information recall, analysis, and presentation. All rubrics are derived from carefully selected expert-written investigative articles and are constructed through a four-stage LLM+human pipeline that combines automatic extraction with over 400 human-hours of expert review, ensuring that the criteria are atomic, verifiable, and aligned with human expert judgment. We evaluate several state-of-the-art deep-research systems on Deep Research Bench II and find that even the strongest models satisfy fewer than 50% of the rubrics, revealing a substantial gap between current DRSs and human experts.

muset-ai muset.ai
·
Jan 13

EAQuant: Enhancing Post-Training Quantization for MoE Models via Expert-Aware Optimization

Mixture-of-Experts (MoE) models have emerged as a cornerstone of large-scale deep learning by efficiently distributing computation and enhancing performance. However, their unique architecture-characterized by sparse expert activation and dynamic routing mechanisms-introduces inherent complexities that challenge conventional quantization techniques. Existing post-training quantization (PTQ) methods struggle to address activation outliers, router consistency and sparse expert calibration, leading to significant performance degradation. To bridge this gap, we propose EAQuant, a novel PTQ framework tailored for MoE architectures. Our method systematically tackles these challenges through three key innovations: (1) expert-aware smoothing aggregation to suppress activation outliers and stabilize quantization, (2) router logits distribution alignment to preserve expert selection consistency post-quantization, and (3) expert-level calibration data balance to optimize sparsely activated experts. Extensive experiments across W4A4 and extreme W3A4 quantization configurations demonstrate that EAQuant significantly outperforms existing methods, achieving average score improvements of 1.15 - 2.28% across three diverse MoE architectures, with particularly pronounced gains in reasoning tasks and robust performance retention under aggressive quantization. By integrating these innovations, EAQuant establishes a new state-of-the-art for high-precision, efficient MoE model compression. Our code is available at https://github.com/darren-fzq/EAQuant.

  • 8 authors
·
Jun 16, 2025

Expert Evaluation of Clinical AI Tools on Real Point-of-Care Clinical Queries

Physicians now pose millions of clinical questions to AI tools each week, yet these tools are evaluated largely on hypothetical or exam-style questions, not those actually asked in practice. We report a blinded evaluation built on 620 Real-world Point-Of-Care Queries (Real-POCQi) submitted to the OpenEvidence (OE) platform by physicians spanning 30 specialties, as well as 187 questions from HealthBench. 149 practicing physicians across 36 states made head-to-head comparisons between answers from three frontier general-purpose models (Claude Opus 4.8, Gemini 3.1 Pro, and GPT-5.5) and a specialized clinical tool (OE), with graders matched to each question's specialty. When comparing answers along five dimensions relevant to clinical decision support -- accuracy, clinical utility, source quality, verifiability, & completeness -- physicians scored the specialized tool highest on all axes; in the primary analysis on Real-POCQi, win differences (margins between win and loss rates) ranged from 25 to 39 percentage points (p<0.001). Results remained consistent in sensitivity analyses stratifying by citation display, answer length, OE-user status, and Real-POCQi versus HealthBench. In parallel, LLM judges were found to systematically differ from expert judges, though both generally agreed on the best model. These findings underscore two conclusions: (i) AI tool evaluations should reflect real-world query distributions and use expert judges that mirror the specialization defining modern medicine and (ii) the consistent advantage of the specialized tool over general-purpose models does not necessarily mean that the latter cannot serve similar purposes, but that targeted engineering and customization can yield meaningful gains in performance for its users. We release Real-POCQi as a public benchmark, as well as the prespecified statistical analysis for reproducing results of this study.

  • 8 authors
·
Jun 26

iSight: Towards expert-AI co-assessment for improved immunohistochemistry staining interpretation

Immunohistochemistry (IHC) provides information on protein expression in tissue sections and is commonly used to support pathology diagnosis and disease triage. While AI models for H\&E-stained slides show promise, their applicability to IHC is limited due to domain-specific variations. Here we introduce HPA10M, a dataset that contains 10,495,672 IHC images from the Human Protein Atlas with comprehensive metadata included, and encompasses 45 normal tissue types and 20 major cancer types. Based on HPA10M, we trained iSight, a multi-task learning framework for automated IHC staining assessment. iSight combines visual features from whole-slide images with tissue metadata through a token-level attention mechanism, simultaneously predicting staining intensity, location, quantity, tissue type, and malignancy status. On held-out data, iSight achieved 85.5\% accuracy for location, 76.6\% for intensity, and 75.7\% for quantity, outperforming fine-tuned foundation models (PLIP, CONCH) by 2.5--10.2\%. In addition, iSight demonstrates well-calibrated predictions with expected calibration errors of 0.0150-0.0408. Furthermore, in a user study with eight pathologists evaluating 200 images from two datasets, iSight outperformed initial pathologist assessments on the held-out HPA dataset (79\% vs 68\% for location, 70\% vs 57\% for intensity, 68\% vs 52\% for quantity). Inter-pathologist agreement also improved after AI assistance in both held-out HPA (Cohen's κ increased from 0.63 to 0.70) and Stanford TMAD datasets (from 0.74 to 0.76), suggesting expert--AI co-assessment can improve IHC interpretation. This work establishes a foundation for AI systems that can improve IHC diagnostic accuracy and highlights the potential for integrating iSight into clinical workflows to enhance the consistency and reliability of IHC assessment.

  • 20 authors
·
Feb 3

From System 1 to System 2: A Survey of Reasoning Large Language Models

Achieving human-level intelligence requires refining the transition from the fast, intuitive System 1 to the slower, more deliberate System 2 reasoning. While System 1 excels in quick, heuristic decisions, System 2 relies on logical reasoning for more accurate judgments and reduced biases. Foundational Large Language Models (LLMs) excel at fast decision-making but lack the depth for complex reasoning, as they have not yet fully embraced the step-by-step analysis characteristic of true System 2 thinking. Recently, reasoning LLMs like OpenAI's o1/o3 and DeepSeek's R1 have demonstrated expert-level performance in fields such as mathematics and coding, closely mimicking the deliberate reasoning of System 2 and showcasing human-like cognitive abilities. This survey begins with a brief overview of the progress in foundational LLMs and the early development of System 2 technologies, exploring how their combination has paved the way for reasoning LLMs. Next, we discuss how to construct reasoning LLMs, analyzing their features, the core methods enabling advanced reasoning, and the evolution of various reasoning LLMs. Additionally, we provide an overview of reasoning benchmarks, offering an in-depth comparison of the performance of representative reasoning LLMs. Finally, we explore promising directions for advancing reasoning LLMs and maintain a real-time https://github.com/zzli2022/Awesome-Slow-Reason-System{GitHub Repository} to track the latest developments. We hope this survey will serve as a valuable resource to inspire innovation and drive progress in this rapidly evolving field.

  • 16 authors
·
Feb 24, 2025

Build a Robust QA System with Transformer-based Mixture of Experts

In this paper, we aim to build a robust question answering system that can adapt to out-of-domain datasets. A single network may overfit to the superficial correlation in the training distribution, but with a meaningful number of expert sub-networks, a gating network that selects a sparse combination of experts for each input, and careful balance on the importance of expert sub-networks, the Mixture-of-Experts (MoE) model allows us to train a multi-task learner that can be generalized to out-of-domain datasets. We also explore the possibility of bringing the MoE layers up to the middle of the DistilBERT and replacing the dense feed-forward network with a sparsely-activated switch FFN layers, similar to the Switch Transformer architecture, which simplifies the MoE routing algorithm with reduced communication and computational costs. In addition to model architectures, we explore techniques of data augmentation including Easy Data Augmentation (EDA) and back translation, to create more meaningful variance among the small out-of-domain training data, therefore boosting the performance and robustness of our models. In this paper, we show that our combination of best architecture and data augmentation techniques achieves a 53.477 F1 score in the out-of-domain evaluation, which is a 9.52% performance gain over the baseline. On the final test set, we reported a higher 59.506 F1 and 41.651 EM. We successfully demonstrate the effectiveness of Mixture-of-Expert architecture in a Robust QA task.

  • 3 authors
·
Mar 19, 2022

How to Build AI Agents by Augmenting LLMs with Codified Human Expert Domain Knowledge? A Software Engineering Framework

Critical domain knowledge typically resides with few experts, creating organizational bottlenecks in scalability and decision-making. Non-experts struggle to create effective visualizations, leading to suboptimal insights and diverting expert time. This paper investigates how to capture and embed human domain knowledge into AI agent systems through an industrial case study. We propose a software engineering framework to capture human domain knowledge for engineering AI agents in simulation data visualization by augmenting a Large Language Model (LLM) with a request classifier, Retrieval-Augmented Generation (RAG) system for code generation, codified expert rules, and visualization design principles unified in an agent demonstrating autonomous, reactive, proactive, and social behavior. Evaluation across five scenarios spanning multiple engineering domains with 12 evaluators demonstrates 206% improvement in output quality, with our agent achieving expert-level ratings in all cases versus baseline's poor performance, while maintaining superior code quality with lower variance. Our contributions are: an automated agent-based system for visualization generation and a validated framework for systematically capturing human domain knowledge and codifying tacit expert knowledge into AI agents, demonstrating that non-experts can achieve expert-level outcomes in specialized domains.

  • 9 authors
·
Jan 21

ExpertWeave: Efficiently Serving Expert-Specialized Fine-Tuned Adapters at Scale

Expert-Specialized Fine-Tuning (ESFT) adapts Mixture-of-Experts (MoE) large language models to enhance their task-specific performance by selectively tuning the top-activated experts for the task. Serving these fine-tuned models at scale is challenging: deploying merged models in isolation is prohibitively resource-hungry, while existing multi-adapter serving systems with LoRA-style additive updates are incompatible with ESFT's expert-oriented paradigm. We present ExpertWeave, a system that serves multiple ESFT adapters concurrently over a single shared MoE base model, drastically reducing the memory footprint and improving resource utilization. To seamlessly integrate into existing inference pipelines for MoE models with non-intrusive modifications and minimal latency overhead, ExpertWeave introduces a virtual-memory-assisted expert weight manager that co-locates base-model and adapter experts without incurring memory overhead from fragmentation, and a fused kernel for batched rerouting to enable lightweight redirection of tokens to the appropriate experts at runtime. Our evaluations show that ExpertWeave can simultaneously serve multiple adapters of a 16B MoE model on a single accelerator where the baseline runs out of memory, or provides up to 94x more KV cache capacity and achieves up to 18% higher throughput while using comparable resources, all without compromising model accuracy. ExpertWeave maintains low overhead even when scaling to 20 adapters, with a 4-11% latency increase compared with serving the base model alone. Source code will be released soon.

  • 7 authors
·
Aug 24, 2025

Composition of Experts: A Modular Compound AI System Leveraging Large Language Models

Large Language Models (LLMs) have achieved remarkable advancements, but their monolithic nature presents challenges in terms of scalability, cost, and customization. This paper introduces the Composition of Experts (CoE), a modular compound AI system leveraging multiple expert LLMs. CoE leverages a router to dynamically select the most appropriate expert for a given input, enabling efficient utilization of resources and improved performance. We formulate the general problem of training a CoE and discuss inherent complexities associated with it. We propose a two-step routing approach to address these complexities that first uses a router to classify the input into distinct categories followed by a category-to-expert mapping to obtain desired experts. CoE offers a flexible and cost-effective solution to build compound AI systems. Our empirical evaluation demonstrates the effectiveness of CoE in achieving superior performance with reduced computational overhead. Given that CoE comprises of many expert LLMs it has unique system requirements for cost-effective serving. We present an efficient implementation of CoE leveraging SambaNova SN40L RDUs unique three-tiered memory architecture. CoEs obtained using open weight LLMs Qwen/Qwen2-7B-Instruct, google/gemma-2-9b-it, google/gemma-2-27b-it, meta-llama/Llama-3.1-70B-Instruct and Qwen/Qwen2-72B-Instruct achieve a score of 59.4 with merely 31 billion average active parameters on Arena-Hard and a score of 9.06 with 54 billion average active parameters on MT-Bench.

  • 11 authors
·
Dec 2, 2024

AesopAgent: Agent-driven Evolutionary System on Story-to-Video Production

The Agent and AIGC (Artificial Intelligence Generated Content) technologies have recently made significant progress. We propose AesopAgent, an Agent-driven Evolutionary System on Story-to-Video Production. AesopAgent is a practical application of agent technology for multimodal content generation. The system integrates multiple generative capabilities within a unified framework, so that individual users can leverage these modules easily. This innovative system would convert user story proposals into scripts, images, and audio, and then integrate these multimodal contents into videos. Additionally, the animating units (e.g., Gen-2 and Sora) could make the videos more infectious. The AesopAgent system could orchestrate task workflow for video generation, ensuring that the generated video is both rich in content and coherent. This system mainly contains two layers, i.e., the Horizontal Layer and the Utility Layer. In the Horizontal Layer, we introduce a novel RAG-based evolutionary system that optimizes the whole video generation workflow and the steps within the workflow. It continuously evolves and iteratively optimizes workflow by accumulating expert experience and professional knowledge, including optimizing the LLM prompts and utilities usage. The Utility Layer provides multiple utilities, leading to consistent image generation that is visually coherent in terms of composition, characters, and style. Meanwhile, it provides audio and special effects, integrating them into expressive and logically arranged videos. Overall, our AesopAgent achieves state-of-the-art performance compared with many previous works in visual storytelling. Our AesopAgent is designed for convenient service for individual users, which is available on the following page: https://aesopai.github.io/.

  • 12 authors
·
Mar 11, 2024

FashionVQA: A Domain-Specific Visual Question Answering System

Humans apprehend the world through various sensory modalities, yet language is their predominant communication channel. Machine learning systems need to draw on the same multimodal richness to have informed discourses with humans in natural language; this is particularly true for systems specialized in visually-dense information, such as dialogue, recommendation, and search engines for clothing. To this end, we train a visual question answering (VQA) system to answer complex natural language questions about apparel in fashion photoshoot images. The key to the successful training of our VQA model is the automatic creation of a visual question-answering dataset with 168 million samples from item attributes of 207 thousand images using diverse templates. The sample generation employs a strategy that considers the difficulty of the question-answer pairs to emphasize challenging concepts. Contrary to the recent trends in using several datasets for pretraining the visual question answering models, we focused on keeping the dataset fixed while training various models from scratch to isolate the improvements from model architecture changes. We see that using the same transformer for encoding the question and decoding the answer, as in language models, achieves maximum accuracy, showing that visual language models (VLMs) make the best visual question answering systems for our dataset. The accuracy of the best model surpasses the human expert level, even when answering human-generated questions that are not confined to the template formats. Our approach for generating a large-scale multimodal domain-specific dataset provides a path for training specialized models capable of communicating in natural language. The training of such domain-expert models, e.g., our fashion VLM model, cannot rely solely on the large-scale general-purpose datasets collected from the web.

  • 3 authors
·
Aug 23, 2022

MRMR: A Realistic and Expert-Level Multidisciplinary Benchmark for Reasoning-Intensive Multimodal Retrieval

We introduce MRMR, the first expert-level multidisciplinary multimodal retrieval benchmark requiring intensive reasoning. MRMR contains 1,502 queries spanning 23 domains, with positive documents carefully verified by human experts. Compared to prior benchmarks, MRMR introduces three key advancements. First, it challenges retrieval systems across diverse areas of expertise, enabling fine-grained model comparison across domains. Second, queries are reasoning-intensive, with images requiring deeper interpretation such as diagnosing microscopic slides. We further introduce Contradiction Retrieval, a novel task requiring models to identify conflicting concepts. Finally, queries and documents are constructed as image-text interleaved sequences. Unlike earlier benchmarks restricted to single images or unimodal documents, MRMR offers a realistic setting with multi-image queries and mixed-modality corpus documents. We conduct an extensive evaluation of 4 categories of multimodal retrieval systems and 14 frontier models on MRMR. The text embedding model Qwen3-Embedding with LLM-generated image captions achieves the highest performance, highlighting substantial room for improving multimodal retrieval models. Although latest multimodal models such as Ops-MM-Embedding perform competitively on expert-domain queries, they fall short on reasoning-intensive tasks. We believe that MRMR paves the way for advancing multimodal retrieval in more realistic and challenging scenarios.

  • 8 authors
·
Oct 10, 2025 2

Citrus: Leveraging Expert Cognitive Pathways in a Medical Language Model for Advanced Medical Decision Support

Large language models (LLMs), particularly those with reasoning capabilities, have rapidly advanced in recent years, demonstrating significant potential across a wide range of applications. However, their deployment in healthcare, especially in disease reasoning tasks, is hindered by the challenge of acquiring expert-level cognitive data. In this paper, we introduce Citrus, a medical language model that bridges the gap between clinical expertise and AI reasoning by emulating the cognitive processes of medical experts. The model is trained on a large corpus of simulated expert disease reasoning data, synthesized using a novel approach that accurately captures the decision-making pathways of clinicians. This approach enables Citrus to better simulate the complex reasoning processes involved in diagnosing and treating medical conditions.To further address the lack of publicly available datasets for medical reasoning tasks, we release the last-stage training data, including a custom-built medical diagnostic dialogue dataset. This open-source contribution aims to support further research and development in the field. Evaluations using authoritative benchmarks such as MedQA, covering tasks in medical reasoning and language understanding, show that Citrus achieves superior performance compared to other models of similar size. These results highlight Citrus potential to significantly enhance medical decision support systems, providing a more accurate and efficient tool for clinical decision-making.

  • 12 authors
·
Feb 25, 2025

Exploiting Inter-Layer Expert Affinity for Accelerating Mixture-of-Experts Model Inference

In large language models like the Generative Pre-trained Transformer, the Mixture of Experts paradigm has emerged as a powerful technique for enhancing model expressiveness and accuracy. However, deploying GPT MoE models for parallel inference on distributed systems presents significant challenges, primarily due to the extensive Alltoall communication required for expert routing and aggregation. This communication bottleneck exacerbates the already complex computational landscape, hindering the efficient utilization of high-performance computing resources. In this paper, we propose a lightweight optimization technique called ExFlow, to largely accelerate the inference of these MoE models. We take a new perspective on alleviating the communication overhead by exploiting the inter-layer expert affinity. Unlike previous methods, our solution can be directly applied to pre-trained MoE models without any fine-tuning or accuracy degradation. By proposing a context-coherent expert parallelism on distributed systems, our design only uses one Alltoall communication to deliver the same functionality while previous methods all require two Alltoalls. By carefully examining the conditional probability in tokens' routing across multiple layers, we proved that pre-trained GPT MoE models implicitly exhibit a strong inter-layer expert affinity. We then design an efficient integer programming model to capture such features and show that by properly placing the experts on corresponding GPUs, we can reduce up to 67% cross-GPU routing latency. Our solution beats the cutting-edge MoE implementations with experts from 8 to 64, with up to 2.2x improvement in inference throughput. We further provide a detailed study of how the model implicitly acquires this expert affinity at the very early training stage and how this affinity evolves and stabilizes during training.

  • 6 authors
·
Jan 16, 2024

Automated Optimization Modeling through Expert-Guided Large Language Model Reasoning

Optimization Modeling (OM) is essential for solving complex decision-making problems. However, the process remains time-consuming and error-prone, heavily relying on domain experts. While Large Language Models (LLMs) show promise in addressing these challenges through their natural language understanding and reasoning capabilities, current approaches face three critical limitations: high benchmark labeling error rates reaching up to 42%, narrow evaluation scope that only considers optimal values, and computational inefficiency due to heavy reliance on multi-agent systems or model fine-tuning. In this work, we first enhance existing datasets through systematic error correction and more comprehensive annotation. Additionally, we introduce LogiOR, a new optimization modeling benchmark from the logistics domain, containing more complex problems with standardized annotations. Furthermore, we present ORThought, a novel framework that leverages expert-level optimization modeling principles through chain-of-thought reasoning to automate the OM process. Through extensive empirical evaluation, we demonstrate that ORThought outperforms existing approaches, including multi-agent frameworks, with particularly significant advantages on complex optimization problems. Finally, we provide a systematic analysis of our method, identifying critical success factors and failure modes, providing valuable insights for future research on LLM-based optimization modeling.

  • 5 authors
·
Aug 20, 2025

Steering Language Generation: Harnessing Contrastive Expert Guidance and Negative Prompting for Coherent and Diverse Synthetic Data Generation

Large Language Models (LLMs) hold immense potential to generate synthetic data of high quality and utility, which has numerous applications from downstream model training to practical data utilisation. However, contemporary models, despite their impressive capacities, consistently struggle to produce both coherent and diverse data. To address the coherency issue, we introduce contrastive expert guidance, where the difference between the logit distributions of fine-tuned and base language models is emphasised to ensure domain adherence. In order to ensure diversity, we utilise existing real and synthetic examples as negative prompts to the model. We deem this dual-pronged approach to logit reshaping as STEER: Semantic Text Enhancement via Embedding Repositioning. STEER operates at inference-time and systematically guides the LLMs to strike a balance between adherence to the data distribution (ensuring semantic fidelity) and deviation from prior synthetic examples or existing real datasets (ensuring diversity and authenticity). This delicate balancing act is achieved by dynamically moving towards or away from chosen representations in the latent space. STEER demonstrates improved performance over previous synthetic data generation techniques, exhibiting better balance between data diversity and coherency across three distinct tasks: hypothesis generation, toxic and non-toxic comment generation, and commonsense reasoning task generation. We demonstrate how STEER allows for fine-tuned control over the diversity-coherency trade-off via its hyperparameters, highlighting its versatility.

  • 5 authors
·
Aug 15, 2023