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Nov 12

A Foundation Model for Spatial Proteomics

Foundation models have begun to transform image analysis by acting as pretrained generalist backbones that can be adapted to many tasks even when post-training data are limited, yet their impact on spatial proteomics, imaging that maps proteins at single-cell resolution, remains limited. Here, we introduce KRONOS, a foundation model built for spatial proteomics. KRONOS was trained in a self-supervised manner on over 47 million image patches covering 175 protein markers, 16 tissue types, and 8 fluorescence-based imaging platforms. We introduce key architectural adaptations to address the high-dimensional, multi-channel, and heterogeneous nature of multiplex imaging. We demonstrate that KRONOS learns biologically meaningful representations across multiple scales, ranging from cellular and microenvironment to tissue levels, enabling it to address diverse downstream tasks, including cell phenotyping, region classification, and patient stratification. Evaluated across 11 independent cohorts, KRONOS achieves state-of-the-art performance across cell phenotyping, treatment response prediction, and retrieval tasks, and is highly data-efficient. KRONOS also introduces the paradigm of segmentation-free patch-level processing for efficient and scalable spatial proteomics analysis, allowing cross-institutional comparisons, and as an image reverse search engine for spatial patterns. Together, these results position KRONOS as a flexible and scalable tool for spatial proteomics. The model is publicly accessible at https://github.com/mahmoodlab/KRONOS.

  • 60 authors
·
Jun 2, 2025

TinyMyo: a Tiny Foundation Model for Flexible EMG Signal Processing at the Edge

Surface electromyography (EMG) is a non-invasive sensing modality used in several domains, including biomechanics, rehabilitation, prosthetic control, and emerging human-machine interaction paradigms. Despite decades of use, significant challenges remain in achieving robust generalization across subjects, recording systems, and acquisition protocols. To tackle these challenges, foundation models (FMs) are gaining traction when targeting end-to-end applications based on EMG signals. Yet, existing EMG FMs remain limited to single downstream tasks and lack deployability on embedded platforms. In this work, we present TinyMyo, a lightweight FM based on a Transformer encoder architecture. The model is pre-trained in a self-supervised manner on publicly available datasets and achieves high reconstruction fidelity with only 3.6M parameters. With minimal task-specific head adaptations, the same backbone is used to tackle multiple downstream tasks, leveraging datasets acquired from diverse sensing locations and hardware platforms. We demonstrate generalization across hand gesture classification, hand kinematic regression, speech production and recognition, with performance comparable to or surpassing the state of the art (SoA), and model size below 5M parameters. We achieve SoA results compared to previous FM-based works on the NinaPro DB5 (89.4pm0.16%), UCI-EMG (97.56pm0.32%), and EPN-612 (96.74pm0.09%) datasets. We report, to the best of our knowledge, the first deployment of an EMG FM on an ultra-low-power microcontroller (GAP9), achieving an average power envelope of 36.45mW. By open-sourcing the pre-trained and the downstream task architectures (https://github.com/pulp-bio/BioFoundation), we aim to provide a flexible resource that can accelerate future research and serve as a common foundation for the EMG community.

PulpBio Pulp Platform Bio
·
Dec 5, 2025

Chest X-ray Foundation Model with Global and Local Representations Integration

Chest X-ray (CXR) is the most frequently ordered imaging test, supporting diverse clinical tasks from thoracic disease detection to postoperative monitoring. However, task-specific classification models are limited in scope, require costly labeled data, and lack generalizability to out-of-distribution datasets. To address these challenges, we introduce CheXFound, a self-supervised vision foundation model that learns robust CXR representations and generalizes effectively across a wide range of downstream tasks. We pretrain CheXFound on a curated CXR-1M dataset, comprising over one million unique CXRs from publicly available sources. We propose a Global and Local Representations Integration (GLoRI) module for downstream adaptations, by incorporating disease-specific local features with global image features for enhanced performance in multilabel classification. Our experimental results show that CheXFound outperforms state-of-the-art models in classifying 40 disease findings across different prevalence levels on the CXR-LT 24 dataset and exhibits superior label efficiency on downstream tasks with limited training data. Additionally, CheXFound achieved significant improvements on new tasks with out-of-distribution datasets, including opportunistic cardiovascular disease risk estimation and mortality prediction. These results highlight CheXFound's strong generalization capabilities, enabling diverse adaptations with improved label efficiency. The project source code is publicly available at https://github.com/RPIDIAL/CheXFound.

  • 6 authors
·
Feb 7, 2025

DeeperBrain: A Neuro-Grounded EEG Foundation Model Towards Universal BCI

Electroencephalography (EEG) foundation models hold significant promise for universal Brain-Computer Interfaces (BCIs). However, existing approaches often rely on end-to-end fine-tuning and exhibit limited efficacy under frozen-probing protocols, lacking the intrinsic universality required for broad generalization. This limitation stems from adapting general-purpose sequence architectures that overlook the biophysical and dynamical principles of neural activity. To bridge this gap, we propose DeeperBrain, a neuro-grounded foundation model integrating domain-specific inductive biases into its model design and learning objectives. Architecturally, DeeperBrain incorporates a volume conduction-aware channel encoding to model spatial mixing via 3D geometry, and a neurodynamics-aware temporal encoding capturing slow adaptations using oscillatory and exponential bases. For pretraining, we introduce a dual-objective strategy combining Masked EEG Reconstruction (MER) for local fidelity and Neurodynamics Statistics Prediction (NSP). NSP enforces alignment with macroscopic brain states by predicting interpretable order parameters, including spectral power, functional connectivity, cross-frequency coupling, and dynamic complexity. Extensive experiments demonstrate that DeeperBrain achieves state-of-the-art or highly competitive performance under end-to-end fine-tuning. Crucially, it maintains superior efficacy under a rigorous frozen-probing protocol, verifying that embedding neuroscientific first principles endows learned representations with the intrinsic universality essential for universal BCI. The code will be publicly available.

  • 6 authors
·
Jan 5

ReconDrive: Fast Feed-Forward 4D Gaussian Splatting for Autonomous Driving Scene Reconstruction

High-fidelity visual reconstruction and novel-view synthesis are essential for realistic closed-loop evaluation in autonomous driving. While 4D Gaussian Splatting (4DGS) offers a promising balance of accuracy and efficiency, existing per-scene optimization methods require costly iterative refinement, rendering them unscalable for extensive urban environments. Conversely, current feed-forward approaches often suffer from degraded photometric quality. To address these limitations, we propose ReconDrive, a feed-forward framework that leverages and extends the 3D foundation model VGGT for rapid, high-fidelity 4DGS generation. Our architecture introduces two core adaptations to tailor the foundation model to dynamic driving scenes: (1) Hybrid Gaussian Prediction Heads, which decouple the regression of spatial coordinates and appearance attributes to overcome the photometric deficiencies inherent in generalized foundation features; and (2) a Static-Dynamic 4D Composition strategy that explicitly captures temporal motion via velocity modeling to represent complex dynamic environments. Benchmarked on nuScenes, ReconDrive significantly outperforms existing feed-forward baselines in reconstruction, novel-view synthesis, and 3D perception. It achieves performance competitive with per-scene optimization while being orders of magnitude faster, providing a scalable and practical solution for realistic driving simulation.

  • 10 authors
·
Mar 7

Segment Anything Model for Medical Image Segmentation: Current Applications and Future Directions

Due to the inherent flexibility of prompting, foundation models have emerged as the predominant force in the fields of natural language processing and computer vision. The recent introduction of the Segment Anything Model (SAM) signifies a noteworthy expansion of the prompt-driven paradigm into the domain of image segmentation, thereby introducing a plethora of previously unexplored capabilities. However, the viability of its application to medical image segmentation remains uncertain, given the substantial distinctions between natural and medical images. In this work, we provide a comprehensive overview of recent endeavors aimed at extending the efficacy of SAM to medical image segmentation tasks, encompassing both empirical benchmarking and methodological adaptations. Additionally, we explore potential avenues for future research directions in SAM's role within medical image segmentation. While direct application of SAM to medical image segmentation does not yield satisfactory performance on multi-modal and multi-target medical datasets so far, numerous insights gleaned from these efforts serve as valuable guidance for shaping the trajectory of foundational models in the realm of medical image analysis. To support ongoing research endeavors, we maintain an active repository that contains an up-to-date paper list and a succinct summary of open-source projects at https://github.com/YichiZhang98/SAM4MIS.

  • 3 authors
·
Jan 7, 2024

SegAgent: Exploring Pixel Understanding Capabilities in MLLMs by Imitating Human Annotator Trajectories

While MLLMs have demonstrated adequate image understanding capabilities, they still struggle with pixel-level comprehension, limiting their practical applications. Current evaluation tasks like VQA and visual grounding remain too coarse to assess fine-grained pixel comprehension accurately. Though segmentation is foundational for pixel-level understanding, existing methods often require MLLMs to generate implicit tokens, decoded through external pixel decoders. This approach disrupts the MLLM's text output space, potentially compromising language capabilities and reducing flexibility and extensibility, while failing to reflect the model's intrinsic pixel-level understanding. Thus, we introduce the Human-Like Mask Annotation Task (HLMAT), a new paradigm where MLLMs mimic human annotators using interactive segmentation tools. Modeling segmentation as a multi-step Markov Decision Process, HLMAT enables MLLMs to iteratively generate text-based click points, achieving high-quality masks without architectural changes or implicit tokens. Through this setup, we develop SegAgent, a model fine-tuned on human-like annotation trajectories, which achieves performance comparable to state-of-the-art (SOTA) methods and supports additional tasks like mask refinement and annotation filtering. HLMAT provides a protocol for assessing fine-grained pixel understanding in MLLMs and introduces a vision-centric, multi-step decision-making task that facilitates exploration of MLLMs' visual reasoning abilities. Our adaptations of policy improvement method StaR and PRM-guided tree search further enhance model robustness in complex segmentation tasks, laying a foundation for future advancements in fine-grained visual perception and multi-step decision-making for MLLMs.

  • 8 authors
·
Mar 11, 2025 2

Robot-Powered Data Flywheels: Deploying Robots in the Wild for Continual Data Collection and Foundation Model Adaptation

Foundation models (FM) have unlocked powerful zero-shot capabilities in vision and language, yet their reliance on internet pretraining data leaves them brittle in unstructured, real-world settings. The messy, real-world data encountered during deployment (e.g. occluded or multilingual text) remains massively underrepresented in existing corpora. Robots, as embodied agents, are uniquely positioned to close this gap: they can act in physical environments to collect large-scale, real-world data that enriches FM training with precisely the examples current models lack. We introduce the Robot-Powered Data Flywheel, a framework that transforms robots from FM consumers into data generators. By deploying robots equipped with FMs in the wild, we enable a virtuous cycle: robots perform useful tasks while collecting real-world data that improves both domain-specific adaptation and domain-adjacent generalization. We instantiate this framework with Scanford, a mobile manipulator deployed in the East Asia Library for 2 weeks. Scanford autonomously scans shelves, identifies books using a vision-language model (VLM), and leverages the library catalog to label images without human annotation. This deployment both aids librarians and produces a dataset to finetune the underlying VLM, improving performance on the domain-specific in-the-wild library setting and on domain-adjacent multilingual OCR benchmarks. Using data collected from 2103 shelves, Scanford improves VLM performance on book identification from 32.0% to 71.8% and boosts domain-adjacent multilingual OCR from 24.8% to 46.6% (English) and 30.8% to 38.0% (Chinese), while saving an ~18.7 hrs of human time. These results highlight how robot-powered data flywheels can both reduce human effort in real deployments and unlock new pathways for continually adapting FMs to the messiness of reality. More details are at: https://scanford-robot.github.io

  • 7 authors
·
Nov 24, 2025

Medical SAM3: A Foundation Model for Universal Prompt-Driven Medical Image Segmentation

Promptable segmentation foundation models such as SAM3 have demonstrated strong generalization capabilities through interactive and concept-based prompting. However, their direct applicability to medical image segmentation remains limited by severe domain shifts, the absence of privileged spatial prompts, and the need to reason over complex anatomical and volumetric structures. Here we present Medical SAM3, a foundation model for universal prompt-driven medical image segmentation, obtained by fully fine-tuning SAM3 on large-scale, heterogeneous 2D and 3D medical imaging datasets with paired segmentation masks and text prompts. Through a systematic analysis of vanilla SAM3, we observe that its performance degrades substantially on medical data, with its apparent competitiveness largely relying on strong geometric priors such as ground-truth-derived bounding boxes. These findings motivate full model adaptation beyond prompt engineering alone. By fine-tuning SAM3's model parameters on 33 datasets spanning 10 medical imaging modalities, Medical SAM3 acquires robust domain-specific representations while preserving prompt-driven flexibility. Extensive experiments across organs, imaging modalities, and dimensionalities demonstrate consistent and significant performance gains, particularly in challenging scenarios characterized by semantic ambiguity, complex morphology, and long-range 3D context. Our results establish Medical SAM3 as a universal, text-guided segmentation foundation model for medical imaging and highlight the importance of holistic model adaptation for achieving robust prompt-driven segmentation under severe domain shift. Code and model will be made available at https://github.com/AIM-Research-Lab/Medical-SAM3.

  • 10 authors
·
Jan 15 4

Large Language Model Adaptation for Networking

Many networking tasks now employ deep learning (DL) to solve complex prediction and system optimization problems. However, current design philosophy of DL-based algorithms entails intensive engineering overhead due to the manual design of deep neural networks (DNNs) for different networking tasks. Besides, DNNs tend to achieve poor generalization performance on unseen data distributions/environments. Motivated by the recent success of large language models (LLMs), for the first time, this work studies the LLM adaptation for networking to explore a more sustainable design philosophy. With the massive pre-trained knowledge and powerful inference ability, LLM can serve as the foundation model, and is expected to achieve "one model for all" with even better performance and stronger generalization for various tasks. In this paper, we present NetLLM, the first LLM adaptation framework that efficiently adapts LLMs to solve networking problems. NetLLM addresses many practical challenges in LLM adaptation, from how to process task-specific information with LLMs, to how to improve the efficiency of answer generation and acquiring domain knowledge for networking. Across three networking-related use cases - viewport prediction (VP), adaptive bitrate streaming (ABR) and cluster job scheduling (CJS), we showcase the effectiveness of NetLLM in LLM adaptation for networking. Results show that the adapted LLM surpasses state-of-the-art algorithms by 10.1-36.6% for VP, 14.5-36.6% for ABR, 6.8-41.3% for CJS, and also achieves superior generalization performance.

  • 7 authors
·
Feb 3, 2024

EyeFound: A Multimodal Generalist Foundation Model for Ophthalmic Imaging

Artificial intelligence (AI) is vital in ophthalmology, tackling tasks like diagnosis, classification, and visual question answering (VQA). However, existing AI models in this domain often require extensive annotation and are task-specific, limiting their clinical utility. While recent developments have brought about foundation models for ophthalmology, they are limited by the need to train separate weights for each imaging modality, preventing a comprehensive representation of multi-modal features. This highlights the need for versatile foundation models capable of handling various tasks and modalities in ophthalmology. To address this gap, we present EyeFound, a multimodal foundation model for ophthalmic images. Unlike existing models, EyeFound learns generalizable representations from unlabeled multimodal retinal images, enabling efficient model adaptation across multiple applications. Trained on 2.78 million images from 227 hospitals across 11 ophthalmic modalities, EyeFound facilitates generalist representations and diverse multimodal downstream tasks, even for detecting challenging rare diseases. It outperforms previous work RETFound in diagnosing eye diseases, predicting systemic disease incidents, and zero-shot multimodal VQA. EyeFound provides a generalizable solution to improve model performance and lessen the annotation burden on experts, facilitating widespread clinical AI applications for retinal imaging.

  • 9 authors
·
May 18, 2024

SARATR-X: Toward Building A Foundation Model for SAR Target Recognition

Despite the remarkable progress in synthetic aperture radar automatic target recognition (SAR ATR), recent efforts have concentrated on detecting and classifying a specific category, e.g., vehicles, ships, airplanes, or buildings. One of the fundamental limitations of the top-performing SAR ATR methods is that the learning paradigm is supervised, task-specific, limited-category, closed-world learning, which depends on massive amounts of accurately annotated samples that are expensively labeled by expert SAR analysts and have limited generalization capability and scalability. In this work, we make the first attempt towards building a foundation model for SAR ATR, termed SARATR-X. SARATR-X learns generalizable representations via self-supervised learning (SSL) and provides a cornerstone for label-efficient model adaptation to generic SAR target detection and classification tasks. Specifically, SARATR-X is trained on 0.18 M unlabelled SAR target samples, which are curated by combining contemporary benchmarks and constitute the largest publicly available dataset till now. Considering the characteristics of SAR images, a backbone tailored for SAR ATR is carefully designed, and a two-step SSL method endowed with multi-scale gradient features was applied to ensure the feature diversity and model scalability of SARATR-X. The capabilities of SARATR-X are evaluated on classification under few-shot and robustness settings and detection across various categories and scenes, and impressive performance is achieved, often competitive with or even superior to prior fully supervised, semi-supervised, or self-supervised algorithms. Our SARATR-X and the curated dataset are released at https://github.com/waterdisappear/SARATR-X to foster research into foundation models for SAR image interpretation.

  • 6 authors
·
May 15, 2024

Towards Robust and Efficient Cloud-Edge Elastic Model Adaptation via Selective Entropy Distillation

The conventional deep learning paradigm often involves training a deep model on a server and then deploying the model or its distilled ones to resource-limited edge devices. Usually, the models shall remain fixed once deployed (at least for some period) due to the potential high cost of model adaptation for both the server and edge sides. However, in many real-world scenarios, the test environments may change dynamically (known as distribution shifts), which often results in degraded performance. Thus, one has to adapt the edge models promptly to attain promising performance. Moreover, with the increasing data collected at the edge, this paradigm also fails to further adapt the cloud model for better performance. To address these, we encounter two primary challenges: 1) the edge model has limited computation power and may only support forward propagation; 2) the data transmission budget between cloud and edge devices is limited in latency-sensitive scenarios. In this paper, we establish a Cloud-Edge Elastic Model Adaptation (CEMA) paradigm in which the edge models only need to perform forward propagation and the edge models can be adapted online. In our CEMA, to reduce the communication burden, we devise two criteria to exclude unnecessary samples from uploading to the cloud, i.e., dynamic unreliable and low-informative sample exclusion. Based on the uploaded samples, we update and distribute the affine parameters of normalization layers by distilling from the stronger foundation model to the edge model with a sample replay strategy. Extensive experimental results on ImageNet-C and ImageNet-R verify the effectiveness of our CEMA.

  • 6 authors
·
Feb 27, 2024

Panoramic Scene Understanding: A Survey from Distortion-Aware Engineering to Sphere-Native Modeling

Panoramic images capture the full visual sphere in a frame, offering context unavailable to conventional cameras. Yet this completeness has an unavoidable geometric cost: the 2-sphere cannot be faithfully mapped to the plane, and every projection introduces distortions that challenge standard vision architectures. This survey traces panoramic scene understanding from projection-based adaptation and distortion-aware engineering to sphere-native modeling, reflecting increasing commitment to spherical geometry. Foundation models form a fourth family, geometry-aware tokenization, which adapts the input interface while reusing perspective-pretrained weights. We review these approaches across five task families: dense prediction, unified multi-task understanding, open-world perception, vision-language reasoning, and dynamic video analysis. Across tasks, the same shift toward spherical geometry recurs. In practice, however, the field has converged not on the strongest sphere-native operators, which are exactly rotation-equivariant but cannot reuse perspective-pretrained backbones and thus have not scaled, but on a compatibility-preserving middle ground combining moderate geometric awareness with large pretrained models. This commitment is uneven: deepest in dense prediction and shallowest in dynamic perception, where methods are spatially sphere-aware yet temporally planar. Foundation-model adaptation has advanced panoramic depth fastest, while layout, surface-normal, and video-level understanding remain largely unexplored. No panoramic foundation model has yet been pretrained on spherical data. We identify five evaluation gaps: spherical-area-weighted metrics, seam-consistency tests, polar-robustness stratification, cross-projection generalization, and standardized open-world protocols. We conclude with a six-point roadmap toward general-purpose panoramic intelligence.

  • 2 authors
·
Jul 14

Harness Continual Learning: Continual Adaptation Beyond Model Parameters

Continual learning has largely been model-centric, treating model parameters as the state that changes with sequential experience. Modern agents can also adapt through a harness of prompts, memories, tools, skills, and routing rules. Because these contents jointly shape later execution, a harness update can disrupt previously reliable behavior even when the model is frozen. This raises a new question: how can an agent continually improve its state outside the model while retaining behavior acquired earlier? We formulate Harness Continual Learning (HCL), a new continual learning paradigm in which the harness evolves around a frozen foundation model, and define the resulting loss of earlier behavior as harness-level forgetting. We instantiate HCL with four execution-facing components: the Task Interface, Experience Memory, Capability Map, and Adaptive Router. We further introduce guarded harness evolution to separate update generation from state commitment. A Continual Optimizer proposes candidate harnesses from post-execution feedback, and a Continual Evaluator commits the resulting candidate harness only after checking current improvement, historical retention, and validity. Experiments on textual reasoning, multimodal perception, and open-world interaction demonstrate capability accumulation and failure recovery, with relative gains exceeding 10% over corresponding baselines in multiple settings. Component ablations assess the contribution of each harness component, while controlled retention sweeps reveal measurable harness-level forgetting and show that the stability--plasticity trade-off can be explicitly adjusted.

  • 6 authors
·
Aug 18

Towards Foundation Model for Chemical Reactor Modeling: Meta-Learning with Physics-Informed Adaptation

Developing accurate models for chemical reactors is often challenging due to the complexity of reaction kinetics and process dynamics. Traditional approaches require retraining models for each new system, limiting generalizability and efficiency. In this work, we take a step toward foundation models for chemical reactor modeling by introducing a neural network framework that generalizes across diverse reactor types and rapidly adapts to new chemical processes. Our approach leverages meta-learning to pretrain the model on a broad set of reactor dynamics, enabling efficient adaptation to unseen reactions with minimal data. To further enhance generalizability, we incorporate physics-informed fine-tuning, ensuring physically consistent adaptation to new reactor conditions. Our framework is evaluated across three integer-order fundamental reactor types - continuous stirred tank reactors, batch reactors, and plug flow reactors - demonstrating superior few-shot adaptation compared to conventional data-driven, physics-informed, and transfer learning approaches. By combining meta-learning with physics-informed adaptation, this work lays the foundation for a generalizable modeling framework, advancing the development of foundation models for chemical engineering applications. Source code is available at https://github.com/killingbear999/chemical-reactor-foundation-model.

  • 2 authors
·
May 19, 2024

A large-scale foundation model enables simulation-to-real adaptation for nuclear magnetic resonance-based molecular structure analysis

Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful tool for molecular structure analysis, and spectral artificial intelligence offers great potential for its rapid and automated interpretation. However, the scarcity of experimental NMR datasets has constrained deep learning in this domain to narrow, task-specific applications that lack broad generalization. Here, we introduce UltraNMR, a large-scale foundation model for NMR that leverages the intrinsic properties of NMR spectra to learn generalizable spectral representations. We collected 158 million paired simulated ^{1}H and ^{13}C NMR spectra to train UltraNMR, employing multiple domain-specific pre-training objectives. UltraNMR captures both intra-spectral and inter-spectral dependencies, enabling seamless simulation-to-real adaptation. We demonstrate that adapting UltraNMR to a range of molecular structure analysis tasks on experimental NMR spectra consistently yields state-of-the-art performance and clearly outperforms UltraNMR variants trained directly on downstream data without simulation pre-training. We also construct a large-scale NMR spectral vector library by encoding simulated NMR spectra using UltraNMR, covering 94 million unique molecules and enabling effective structure-aware retrieval. In real-world applications, UltraNMR facilitates the structural elucidation of two previously unknown natural products from Chinese herbal medicines recorded in the Chinese Pharmacopoeia. These results suggest that large-scale simulation pre-training can effectively bridge the simulation-to-real gap, enabling robust and generalizable molecular structure analysis of real-world NMR spectra.

  • 10 authors
·
Jun 17

SAMGPT: Text-free Graph Foundation Model for Multi-domain Pre-training and Cross-domain Adaptation

Graphs are able to model interconnected entities in many online services, supporting a wide range of applications on the Web. This raises an important question: How can we train a graph foundational model on multiple source domains and adapt to an unseen target domain? A major obstacle is that graphs from different domains often exhibit divergent characteristics. Some studies leverage large language models to align multiple domains based on textual descriptions associated with the graphs, limiting their applicability to text-attributed graphs. For text-free graphs, a few recent works attempt to align different feature distributions across domains, while generally neglecting structural differences. In this work, we propose a novel Structure Alignment framework for text-free Multi-domain Graph Pre-Training and cross-domain adaptation (SAMGPT). It is designed to learn multi-domain knowledge from graphs originating in multiple source domains, which can then be adapted to address applications in an unseen target domain. Specifically, we introduce a set of structure tokens to harmonize structure-based aggregation across source domains during the pre-training phase. Next, for cross-domain adaptation, we design dual prompts, namely, holistic prompts and specific prompts, which adapt unified multi-domain structural knowledge and fine-grained, domain-specific information, respectively, to a target domain. Finally, we conduct comprehensive experiments on seven public datasets to evaluate and analyze the effectiveness of SAMGPT.

  • 5 authors
·
Feb 7, 2025

Imaging foundation model for universal enhancement of non-ideal measurement CT

Non-ideal measurement computed tomography (NICT), which sacrifices optimal imaging standards for new advantages in CT imaging, is expanding the clinical application scope of CT images. However, with the reduction of imaging standards, the image quality has also been reduced, extremely limiting the clinical acceptability. Although numerous studies have demonstrated the feasibility of deep learning for the NICT enhancement in specific scenarios, their high data cost and limited generalizability have become large obstacles. The recent research on the foundation model has brought new opportunities for building a universal NICT enhancement model - bridging the image quality degradation with minimal data cost. However, owing to the challenges in the collection of large pre-training datasets and the compatibility of data variation, no success has been reported. In this paper, we propose a multi-scale integrated Transformer AMPlifier (TAMP), the first imaging foundation model for universal NICT enhancement. It has been pre-trained on a large-scale physical-driven simulation dataset with 3.6 million NICT-ICT image pairs, and is able to directly generalize to the NICT enhancement tasks with various non-ideal settings and body regions. Via the adaptation with few data, it can further achieve professional performance in real-world specific scenarios. Our extensive experiments have demonstrated that the proposed TAMP has significant potential for promoting the exploration and application of NICT and serving a wider range of medical scenarios.

  • 7 authors
·
Oct 2, 2024

Harnessing Vision Foundation Models for High-Performance, Training-Free Open Vocabulary Segmentation

While Contrastive Language-Image Pre-training (CLIP) has advanced open-vocabulary predictions, its performance on semantic segmentation remains suboptimal. This shortfall primarily stems from its spatial-invariant semantic features and constrained resolution. While previous adaptations addressed spatial invariance semantic by modifying the self-attention in CLIP's image encoder, the issue of limited resolution remains unexplored. Different from previous segment-then-splice methods that segment sub-images via a sliding window and splice the results, we introduce a splice-then-segment paradigm that incorporates Segment-Anything Model (SAM) to tackle the resolution issue since SAM excels at extracting fine-grained semantic correlations from high-resolution images. Specifically, we introduce Trident, a training-free framework that first splices features extracted by CLIP and DINO from sub-images, then leverages SAM's encoder to create a correlation matrix for global aggregation, enabling a broadened receptive field for effective segmentation. Besides, we propose a refinement strategy for CLIP's coarse segmentation outputs by transforming them into prompts for SAM, further enhancing the segmentation performance. Trident achieves a significant improvement in the mIoU across eight benchmarks compared with the current SOTA, increasing from 44.4 to 48.6.Code is available at https://github.com/YuHengsss/Trident.

  • 3 authors
·
Nov 14, 2024

A Foundation Model for Instruction-Conditioned In-Context Time Series Tasks

In-context learning (ICL) enables task adaptation at inference time by conditioning on demonstrations rather than updating model parameters. Although recent time-series foundation models incorporate contextual conditioning, retrieval, or example-based prompting, they typically rely on implicit positional structure or task-specific objectives rather than explicit instruction-conditioned input-output demonstrations. We introduce iAmTime, a time-series foundation model trained with instruction-conditioned amortized meta-learning to infer tasks directly from example demonstrations. iAmTime represents each episode as a structured prompt over historical context and future-known variables using specialized semantic tokens that attend to designated time-series regions, exchange information across demonstrations, and inject task information into the query representation. The model combines a Hierarchical Multi-Scope Transformer Encoder, which captures temporal and covariate dynamics while inferring latent task structure from demonstrated input-output mappings, with a Task-Conditioned Patch Decoder, which adapts decoding through expert-based routing. We train iAmTime on large-scale real and synthetic corpora using supervised and self-supervised instruction-conditioned tasks, including forecasting, imputation, reconstruction, classification, anomaly detection, and source de-mixing. Across diverse domains, frequencies, and horizons, iAmTime improves zero-shot adaptation over strong time-series foundation baselines on probabilistic and point forecasting benchmarks, while achieving competitive or superior performance on four non-forecasting tasks.

  • 2 authors
·
Sep 21

Multimodal-Multiresolution Foundation Model for Lunar Remote Sensing

We present a multimodal foundation model for lunar remote sensing, pretrained from scratch on SomBench, a geographically partitioned corpus of nearly two million co-registered tile bundles spanning 11 modalities at two spatial scales (1 m/pixel and 100 m/pixel). The model adapts the TerraMind masked-token architecture with two lunar-specific extensions: acquisition geometry is provided as explicit context, and meter- and hundred-meter-scale tiles are trained jointly so that a single set of weights covers both resolutions. FlexiViT patch embeddings allow adaptation to different patch sizes without retraining, while modality-wise inputs enable flexible multimodal fine-tuning. Qualitative generation experiments suggest the model learns meaningful cross-modal correspondences, including terrain derivatives from elevation and illumination-consistent reflectance from geometry. We evaluate on four benchmarks: crater detection at WAC and NAC scales, irregular mare patch (IMP) segmentation, and polar ice prospectivity regression. Across tasks, the pretrained model matches or outperforms ImageNet-pretrained baselines and an architecturally identical random-init control. On multimodal ice prospectivity regression, pretrained variants achieve the best results, while the random-init model outperforms most baselines, suggesting gains arise from both the architecture and pretraining. Label efficiency is notable for WAC crater detection, where the pretrained model trained on 50% of the data exceeds the strongest ImageNet baseline trained on the full dataset. Among adaptation strategies, LoRA matches or surpasses full fine-tuning on crater detection and IMP segmentation while using far fewer trainable parameters, whereas full fine-tuning performs best for ice prospectivity regression. We release the pretrained checkpoint, benchmark datasets, and fine-tuning code to support reproducible lunar AI research.

  • 22 authors
·
Sep 7

Therm-FM: Foundation Model is ALL YOU NEED for 3D-ICs Thermal Simulation

Data-driven thermal predictors for 3D-ICs are often trained from scratch for each chip design using many high-fidelity finite-element simulations, leading to high data-generation cost and costly cross-design reuse. We propose Therm-FM, a neural operator framework that adapts a pretrained partial differential equation (PDE) foundation model to steady-state and transient 3D-IC thermal simulation. The motivation is that steady-state and transient chip-level heat conduction respectively share elliptic and parabolic operator structures with diffusion-type PDEs, allowing pretrained diffusion priors to provide an effective initialization for thermal-field prediction under heterogeneous materials, dense TSV/microbump interconnects, and package-level boundary conditions. To further reduce data-generation cost, Therm-FM incorporates a thermal-equivalent multi-fidelity training strategy that uses low-cost approximate simulations for thermal-domain adaptation and limited high-fidelity samples for calibration. Experiments on public HotSpot benchmarks and industrial 3D-IC package benchmarks show that Therm-FM achieves up to a 10.6x reduction in mean error and surpasses prior best accuracy with less than 20% of the training data. In cross-chip adaptation, it matches or surpasses full-data baselines in several metrics using only 10--30 target samples. We release datasets, source code, and pretrained models at https://github.com/haiyangxin/Therm-FM.

  • 9 authors
·
May 24

RedDino: A foundation model for red blood cell analysis

Red blood cells (RBCs) are essential to human health, and their precise morphological analysis is important for diagnosing hematological disorders. Despite the promise of foundation models in medical diagnostics, comprehensive AI solutions for RBC analysis remain scarce. We present RedDino, a self-supervised foundation model designed for RBC image analysis. RedDino uses an RBC-specific adaptation of the DINOv2 self-supervised learning framework and is trained on a curated dataset of 1.25 million RBC images from diverse acquisition modalities and sources. Extensive evaluations show that RedDino outperforms existing state-of-the-art models on RBC shape classification. Through assessments including linear probing and nearest neighbor classification, we confirm its strong feature representations and generalization ability. Our main contributions are: (1) a foundation model tailored for RBC analysis, (2) ablation studies exploring DINOv2 configurations for RBC modeling, and (3) a detailed evaluation of generalization performance. RedDino addresses key challenges in computational hematology by capturing nuanced morphological features, advancing the development of reliable diagnostic tools. The source code and pretrained models for RedDino are available at https://github.com/Snarci/RedDino, and the pretrained models can be downloaded from our Hugging Face collection at https://huggingface.co/collections/Snarcy/reddino-689a13e29241d2e5690202fc

  • 4 authors
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Aug 11, 2025 2

FunduSegmenter: Leveraging the RETFound Foundation Model for Joint Optic Disc and Optic Cup Segmentation in Retinal Fundus Images

Purpose: This study introduces the first adaptation of RETFound for joint optic disc (OD) and optic cup (OC) segmentation. RETFound is a well-known foundation model developed for fundus camera and optical coherence tomography images, which has shown promising performance in disease diagnosis. Methods: We propose FunduSegmenter, a model integrating a series of novel modules with RETFound, including a Pre-adapter, a Decoder, a Post-adapter, skip connections with Convolutional Block Attention Module and a Vision Transformer block adapter. The model is evaluated on a proprietary dataset, GoDARTS, and four public datasets, IDRiD, Drishti-GS, RIM-ONE-r3, and REFUGE, through internal verification, external verification and domain generalization experiments. Results: An average Dice similarity coefficient of 90.51% was achieved in internal verification, which outperformed all baselines, some substantially (nnU-Net: 82.91%; DUNet: 89.17%; TransUNet: 87.91%). In all external verification experiments, the average results were about 3% higher than those of the best baseline, and our model was also competitive in domain generalization. Conclusions: This study explored the potential of the latent general representations learned by RETFound for OD and OC segmentation in fundus camera images. Our FunduSegmenter generally outperformed state-of-the-art baseline methods. The proposed modules are general and can be extended to fine-tuning other foundation models. Translational Relevance: The model shows strong stability and generalization on both in-distribution and out-of-distribution data, providing stable OD and OC segmentation. This is an essential step for many automated tasks, from setting the accurate retinal coordinate to biomarker discovery. The code and trained weights are available at: https://github.com/JusticeZzy/FunduSegmenter.

  • 3 authors
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Apr 22

Foundation Model-Driven Semantic Change Detection in Remote Sensing Imagery

Remote sensing (RS) change detection methods can extract critical information on surface dynamics and are an essential means for humans to understand changes in the earth's surface and environment. Among these methods, semantic change detection (SCD) can more effectively interpret the multi-class information contained in bi-temporal RS imagery, providing semantic-level predictions that support dynamic change monitoring. However, due to the limited semantic understanding capability of the model and the inherent complexity of the SCD tasks, existing SCD methods face significant challenges in both performance and paradigm complexity. In this paper, we propose PerASCD, a SCD method driven by RS foundation model PerA, designed to enhance the multi-scale semantic understanding and overall performance. We introduce a modular Cascaded Gated Decoder (CG-Decoder) that simplifies complex SCD decoding pipelines while promoting effective multi-level feature interaction and fusion. In addition, we propose a Soft Semantic Consistency Loss (SSCLoss) to mitigate the numerical instability commonly encountered during SCD training. We further explore the applicability of multiple existing RS foundation models on the SCD task when equipped with the proposed decoder. Experimental results demonstrate that our decoder not only effectively simplifies the paradigm of SCD, but also achieves seamless adaptation across various vision encoders. Our method achieves state-of-the-art (SOTA) performance on two public benchmark datasets, validating its effectiveness. The code is available at https://github.com/SathShen/PerASCD.git.

  • 8 authors
·
Feb 14

SiFo: Wireless Foundation Model for Low-Overhead Site-Specific CSI Feedback

SiFo, a wireless foundation model-based framework, is proposed for low-overhead site-specific channel state information (CSI) feedback. In 3GPP NR, Type-II feedback provides an expressive codebook-based CSI representation, but it requires substantial reference-signal overhead, UE-side search, and feedback. Learning-based site-specific feedback can reduce these online costs while retaining high-quality subspace representation by exploiting deployment-dependent propagation structure. However, existing site-specific designs typically train a dedicated neural network for each new site, which limits scalability when the number of deployments is large. SiFo addresses this scalability issue by pretraining a CSI feedback model across source sites and adapting it to a target site through lightweight calibration. A small set of target-site users reports low-dimensional reference signal received power (RSRP) fingerprints, and their full-CSI-based subspace labels are stored as calibration memory. During online operation, a served user is matched to calibrated users through the same SSB probing and RSRP reporting procedure, so nearby calibration samples provide site-specific subspace guidance without updating model parameters. SiFo therefore transfers common propagation knowledge while retaining local adaptation. Numerical results across ten city scenarios demonstrate that SiFo (i) achieves higher CSI-capture efficiency than separately trained site-specific learning baselines under the same target-site labeled budget, (ii) approaches the high-overhead 3GPP NR Type-II feedback reference using only RSRP measurements collected during online SSB probing, and (iii) converts the high CSI-capture efficiency and low overhead into effective spectral efficiency improvement under limited target-site data.

  • 4 authors
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May 14

ERP-FM: A Foundation Model for Universal ERP Analysis

Foundation models have recently shown strong potential for learning generalizable EEG representations, yet their effectiveness for event-related potential (ERP) analysis remains unclear. In this work, we investigate two fundamental questions: 1) can foundation-model learning benefit ERP analysis, and what limits the transfer of existing EEG foundation models to ERP tasks? 2) can the complementary advantages of single-trial and averaged-trial ERP be integrated into a unified training pipeline? To study these questions, we curate a large-scale ERP corpus comprising 1,517,157 single-trial ERPs from 3,696 subjects across 38 datasets and 18 paradigms. Leveraging this corpus, we introduce ERP-FM, to the best of our knowledge, the first foundation model specifically developed for ERP representation learning. ERP-FM uses single-channel tokenization, temporal and spatial positional embeddings, and mixed masked autoencoding for large-scale single-trial pretraining. We compare our model against 17 existing methods on 12 downstream datasets covering ERP event/condition classification and neurological disease classification. Our model achieves the best overall average rank across all evaluated methods. Furthermore, our analyses reveal that both ERP and non-ERP EEG pretraining can provide transferable representations for ERP tasks, while fine-grained temporal tokenization is critical for effectively modeling transient ERP dynamics. We further find that single-trial and averaged-trial ERP play complementary rather than competing roles. Combining single-trial pretraining with averaged-trial downstream adaptation substantially improves neurological disease analysis. Overall, these findings establish an effective foundation-model training pipeline for ERP analysis and represent significant progress toward generalizable ERP representation learning. Source code: https://github.com/DL4mHealth/ERP-FM

  • 6 authors
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Sep 25

VisionTS++: Cross-Modal Time Series Foundation Model with Continual Pre-trained Vision Backbones

Recent studies have indicated that vision models pre-trained on images can serve as time series foundation models (TSFMs) by reformulating time series forecasting (TSF) as image reconstruction. However, effective cross-modal transfer from vision to time series remains challenging due to three discrepancies: (1) the data-modality gap between structured, bounded image data and unbounded, heterogeneous time series; (2) the multivariate-forecasting gap between fixed RGB-three-channel vision models and time series with arbitrary numbers of variates; and (3) the probabilistic-forecasting gap between the deterministic outputs of vision models and the requirement for uncertainty-aware probabilistic predictions. To bridge these gaps, we propose VisonTS++, a TSFM based on continual pre-training of a vision model on large-scale time series. Our approach introduces three key innovations: (1) vision-model-based filtering to identify high-quality sequences to stabilize pre-training and mitigate modality gap; (2) colorized multivariate conversion, encoding multivariate series as multi-subfigure RGB images to enhance cross-variate modeling; (3) multi-quantile forecasting, using parallel reconstruction heads to generate quantile forecasts without parametric assumptions. Experiments show that VisionTS++ achieves state-of-the-art performance in both in-distribution and out-of-distribution forecasting, outperforming specialized TSFMs by 6%-44% in MSE reduction and ranking first in GIFT-Eval benchmark which comprises 23 datasets across 7 domains. Our work demonstrates that with appropriate adaptation, vision models can effectively generalize to TSF, thus advancing the pursuit of universal TSFMs. Code is available at https://github.com/HALF111/VisionTSpp.

  • 8 authors
·
Aug 6, 2025

Self-Geometry: GT-Free and Plug-and-Play Test-Time Adaptation for Geometrically Consistent 3D Vision Foundation Models

Recent Vision Foundation Models (VFMs) predict depth, camera pose, and pointmap in a single forward pass without per-scene optimization, achieving strong generalization. However, enforcing explicit multi-view geometric consistency, e.g., through bundle adjustment, is computationally costly and is thus not imposed during VFM pretraining, so such inconsistency can arise. To address this, implicit self-consistency derived from model outputs (e.g., pointmaps, features), though enforced at test-time in prior work, delivers inherently limited performance gain, especially on scenes where the pretrained VFM is highly inaccurate. In contrast to this implicit signal, we propose Self-Geometry, a plug-and-play test-time adaptation pipeline that directly imposes explicit multi-view geometric constraints using 2D pixel correspondences as pseudo ground-truth. Our proposed Self-Geometry consists of Geometric Disentanglement Optimization, which combines Multi-View Consistency and Epipolar Consistency losses with Gradient Disentanglement to prevent gradient conflict; Frame Angular-Neighbor, a view sampler based on SO(3) geodesic distances for lightly imposing these constraints; and Lightweight TTA, which adapts VFMs via LoRA. Our method achieves consistent improvements in both pose and geometry estimation across six VFMs (VGGT, π^3, DA3-Giant/Large/Base/Small) and four benchmarks (7Scenes, ETH3D, ScanNet++, HiRoom).

GlucoFM: A Dual-Stream Foundation Model for Continuous Glucose Monitoring

Continuous glucose monitoring (CGM) provides a dense view of daily metabolic physiology, yet existing generic time-series and CGM-specific foundation models often encode glucose traces as entangled single-stream sequences, leaving the distinct temporal structure of glycemic dynamics only implicitly modeled. We present GlucoFM, a lightweight CGM foundation model that aligns irregular recordings to a 24-hour chronological grid, preserves observation masks, and decomposes glucose dynamics into slow physiological state and transient event streams, capturing low-frequency glycemic baselines and short-term deviations that may reflect acute physiological responses or sensor artifacts. GlucoFM is pretrained on 109,066 hours of unlabeled CGM recordings from 477 subjects with two complementary objectives: masked contextual latent prediction over fused daily representations and temporal dynamics prediction over state and event streams. Across four diverse cohorts and seven clinical prediction tasks, GlucoFM achieves the strongest subject-disjoint linear-probing performance among evaluated baselines, improving average PR-AUC by 4.1 points over the best CGM-specific foundation model. Its gains are most pronounced on core metabolic outcomes, leading PR-AUC on all diabetes-risk and β-cell dysfunction tasks and on 3 of 4 insulin-resistance tasks. GlucoFM also achieves the best overall cross-dataset transfer performance and strong few-shot adaptation among evaluated methods, and consistent gains when aggregating multiple days for subject-level prediction, highlighting physiology-aware decomposition as an effective inductive bias for transferable CGM representation learning.

  • 14 authors
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May 28 1

Integrating Reinforcement Learning with Foundation Models for Autonomous Robotics: Methods and Perspectives

Foundation models (FMs), large deep learning models pre-trained on vast, unlabeled datasets, exhibit powerful capabilities in understanding complex patterns and generating sophisticated outputs. However, they often struggle to adapt to specific tasks. Reinforcement learning (RL), which allows agents to learn through interaction and feedback, offers a compelling solution. Integrating RL with FMs enables these models to achieve desired outcomes and excel at particular tasks. Additionally, RL can be enhanced by leveraging the reasoning and generalization capabilities of FMs. This synergy is revolutionizing various fields, including robotics. FMs, rich in knowledge and generalization, provide robots with valuable information, while RL facilitates learning and adaptation through real-world interactions. This survey paper comprehensively explores this exciting intersection, examining how these paradigms can be integrated to advance robotic intelligence. We analyze the use of foundation models as action planners, the development of robotics-specific foundation models, and the mutual benefits of combining FMs with RL. Furthermore, we present a taxonomy of integration approaches, including large language models, vision-language models, diffusion models, and transformer-based RL models. We also explore how RL can utilize world representations learned from FMs to enhance robotic task execution. Our survey aims to synthesize current research and highlight key challenges in robotic reasoning and control, particularly in the context of integrating FMs and RL--two rapidly evolving technologies. By doing so, we seek to spark future research and emphasize critical areas that require further investigation to enhance robotics. We provide an updated collection of papers based on our taxonomy, accessible on our open-source project website at: https://github.com/clmoro/Robotics-RL-FMs-Integration.

  • 8 authors
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Oct 21, 2024

VSLLaVA: a pipeline of large multimodal foundation model for industrial vibration signal analysis

While Large Multimodal Models (LMMs) excel in general multimodal tasks, they lack the domain-specific knowledge for industrial vibration signal analysis. This paper introduces VSLLaVA, a comprehensive pipeline that utilizes expert knowledge-guided instruction tuning and evaluation to create an end-to-end LMM for signal analysis. To achieve this, we construct a novel Signal-Question-Answer (SQA) dataset using an expert rule-based signal generator. This dataset facilitates a two-stage learning procedure. The first step is efficient instruction fine-tuning with Low-Rank Adaptation (LoRA), which imparts specialized signal identification capabilities. Subsequently, we designed a tailored Group Relative Policy Optimization (GRPO) to refine the reasoning capabilities and enhance classification robustness. Then, a dual-mode evaluation framework is proposed, combining an LLM referee with expert rules for semantic assessment using quantitative metrics for numerical and textual accuracy, which reveals that VSLLaVA significantly improves performance in signal type identification and parameter analysis, and makes progress in the identification and parameter analysis of fault-related signals. This research demonstrates a viable approach for developing specialized foundational models for complex industrial applications and marks a transition from conventional task-specific systems to a cohesive, interactive foundational model.

  • 7 authors
·
Sep 3, 2024

MonkeyOCRv2: A Visual-Text Foundation Model for Document AI

Mainstream visual encoders are pretrained on natural images and cannot be effectively applied to document images without document-oriented adaptation, as dense text and fine-grained character strokes demand character-level visual perception. We present MonkeyOCRv2, a visual-text pretrained model for document AI. First, we construct MonkeyDoc v2, to our knowledge the largest document-image pretraining corpus, comprising 113 million images spanning 17 languages. Second, we propose a pretraining strategy that jointly learns image-to-text generation and pixel-level document reconstruction: the former aligns visual representations with textual content, while the latter preserves character strokes and layout details. Extensive experiments are conducted on five representative document analysis tasks, including text recognition, formula recognition, text detection, document tampering detection, and overlapping text segmentation. Replacing the original encoders with MonkeyOCRv2 consistently improves performance across all five tasks. Finally, we validate its effectiveness as the vision encoder of multimodal large language models on the more challenging tasks of document parsing and document understanding. Kept frozen and paired with a lightweight language model, it yields a 0.7B document parsing model that sets a new open-source state-of-the-art on MDPBench, a recent benchmark spanning digital-born and photographed documents across 17 languages, surpassing the previous best 3B dots.mocr by 2.8% absolute with a vision encoder roughly 11times smaller. The frozen encoder also powers a document understanding model that outperforms counterparts built on CLIP, DINO, and SAM across eight benchmarks under identical training settings. These results suggest that document-oriented visual pretraining can serve as a foundation for document intelligence in its own right.

VLRLab-OCR VLRLab-OCR
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Jul 12 2

Facet-0: A Robotic Foundation Model for Contact-Rich Precise Manipulation

Real-world robotic assembly at sub-millimeter tolerances demands spatial precision, compliant interaction, and robustness to contact failures. We present Facet-0, a robotic foundation model that predicts and values the contact consequences of its actions. Facet-0 unifies multimodal representation learning and reinforcement learning (RL) post-training around a joint action-wrench proposal: a causal wrench history is aligned with vision-language semantics and kinematic state, and flow matching generates each action chunk together with the future wrist-wrench profile it is expected to induce. Deployment rollouts train a distributional Action-Wrench Critic to distinguish motions with similar task progress but different contact outcomes, while phase-aware rewards and contact-selective credit concentrate policy improvement on decisive interactions. To accommodate part-specific dynamics, a lightweight bounded actor reuses the frozen representation for on-robot adaptation; RL remains defined over executable Cartesian actions, while an auxiliary wrench head preserves predictive, non-commanded action-contact coupling. Trained on ManuFacet-1K, a 1,000-hour force-synchronized corpus spanning three embodiments and multiple manufacturing cells, the bounded task-adapted system reaches 82% mean success on five sub-millimeter computer-assembly tasks, compared with 15% for the strongest baseline, with 0.5 mm placement accuracy and 50 ms command latency.

  • 9 authors
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Aug 31

ViNT: A Foundation Model for Visual Navigation

General-purpose pre-trained models ("foundation models") have enabled practitioners to produce generalizable solutions for individual machine learning problems with datasets that are significantly smaller than those required for learning from scratch. Such models are typically trained on large and diverse datasets with weak supervision, consuming much more training data than is available for any individual downstream application. In this paper, we describe the Visual Navigation Transformer (ViNT), a foundation model that aims to bring the success of general-purpose pre-trained models to vision-based robotic navigation. ViNT is trained with a general goal-reaching objective that can be used with any navigation dataset, and employs a flexible Transformer-based architecture to learn navigational affordances and enable efficient adaptation to a variety of downstream navigational tasks. ViNT is trained on a number of existing navigation datasets, comprising hundreds of hours of robotic navigation from a variety of different robotic platforms, and exhibits positive transfer, outperforming specialist models trained on singular datasets. ViNT can be augmented with diffusion-based subgoal proposals to explore novel environments, and can solve kilometer-scale navigation problems when equipped with long-range heuristics. ViNT can also be adapted to novel task specifications with a technique inspired by prompt-tuning, where the goal encoder is replaced by an encoding of another task modality (e.g., GPS waypoints or routing commands) embedded into the same space of goal tokens. This flexibility and ability to accommodate a variety of downstream problem domains establishes ViNT as an effective foundation model for mobile robotics. For videos, code, and model checkpoints, see our project page at https://visualnav-transformer.github.io.

  • 7 authors
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Jun 26, 2023

General Object Foundation Model for Images and Videos at Scale

We present GLEE in this work, an object-level foundation model for locating and identifying objects in images and videos. Through a unified framework, GLEE accomplishes detection, segmentation, tracking, grounding, and identification of arbitrary objects in the open world scenario for various object perception tasks. Adopting a cohesive learning strategy, GLEE acquires knowledge from diverse data sources with varying supervision levels to formulate general object representations, excelling in zero-shot transfer to new data and tasks. Specifically, we employ an image encoder, text encoder, and visual prompter to handle multi-modal inputs, enabling to simultaneously solve various object-centric downstream tasks while maintaining state-of-the-art performance. Demonstrated through extensive training on over five million images from diverse benchmarks, GLEE exhibits remarkable versatility and improved generalization performance, efficiently tackling downstream tasks without the need for task-specific adaptation. By integrating large volumes of automatically labeled data, we further enhance its zero-shot generalization capabilities. Additionally, GLEE is capable of being integrated into Large Language Models, serving as a foundational model to provide universal object-level information for multi-modal tasks. We hope that the versatility and universality of our method will mark a significant step in the development of efficient visual foundation models for AGI systems. The model and code will be released at https://glee-vision.github.io .

  • 6 authors
·
Dec 14, 2023 2

Lotus: Diffusion-based Visual Foundation Model for High-quality Dense Prediction

Leveraging the visual priors of pre-trained text-to-image diffusion models offers a promising solution to enhance zero-shot generalization in dense prediction tasks. However, existing methods often uncritically use the original diffusion formulation, which may not be optimal due to the fundamental differences between dense prediction and image generation. In this paper, we provide a systemic analysis of the diffusion formulation for the dense prediction, focusing on both quality and efficiency. And we find that the original parameterization type for image generation, which learns to predict noise, is harmful for dense prediction; the multi-step noising/denoising diffusion process is also unnecessary and challenging to optimize. Based on these insights, we introduce Lotus, a diffusion-based visual foundation model with a simple yet effective adaptation protocol for dense prediction. Specifically, Lotus is trained to directly predict annotations instead of noise, thereby avoiding harmful variance. We also reformulate the diffusion process into a single-step procedure, simplifying optimization and significantly boosting inference speed. Additionally, we introduce a novel tuning strategy called detail preserver, which achieves more accurate and fine-grained predictions. Without scaling up the training data or model capacity, Lotus achieves SoTA performance in zero-shot depth and normal estimation across various datasets. It also significantly enhances efficiency, being hundreds of times faster than most existing diffusion-based methods.

  • 9 authors
·
Sep 26, 2024 2

A Fully Open and Generalizable Foundation Model for Ultrasound Clinical Applications

Artificial intelligence (AI) that can effectively learn ultrasound representations by integrating multi-source data holds significant promise for advancing clinical care. However, the scarcity of large labeled datasets in real-world clinical environments and the limited generalizability of task-specific models have hindered the development of generalizable clinical AI models for ultrasound applications. In this study, we present EchoCare, a novel ultrasound foundation model for generalist clinical use, developed via self-supervised learning on our curated, publicly available, large-scale dataset EchoCareData. EchoCareData comprises 4.5 million ultrasound images, sourced from over 23 countries across 5 continents and acquired via a diverse range of distinct imaging devices, thus encompassing global cohorts that are multi-center, multi-device, and multi-ethnic. Unlike prior studies that adopt off-the-shelf vision foundation model architectures, we introduce a hierarchical classifier into EchoCare to enable joint learning of pixel-level and representation-level features, capturing both global anatomical contexts and local ultrasound characteristics. With minimal training, EchoCare outperforms state-of-the-art comparison models across 10 representative ultrasound benchmarks of varying diagnostic difficulties, spanning disease diagnosis, lesion segmentation, organ detection, landmark prediction, quantitative regression, imaging enhancement and report generation. The code and pretrained model are publicly released, rendering EchoCare accessible for fine-tuning and local adaptation, supporting extensibility to additional applications. EchoCare provides a fully open and generalizable foundation model to boost the development of AI technologies for diverse clinical ultrasound applications.

  • 25 authors
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Sep 15, 2025

SAM-E: Leveraging Visual Foundation Model with Sequence Imitation for Embodied Manipulation

Acquiring a multi-task imitation policy in 3D manipulation poses challenges in terms of scene understanding and action prediction. Current methods employ both 3D representation and multi-view 2D representation to predict the poses of the robot's end-effector. However, they still require a considerable amount of high-quality robot trajectories, and suffer from limited generalization in unseen tasks and inefficient execution in long-horizon reasoning. In this paper, we propose SAM-E, a novel architecture for robot manipulation by leveraging a vision-foundation model for generalizable scene understanding and sequence imitation for long-term action reasoning. Specifically, we adopt Segment Anything (SAM) pre-trained on a huge number of images and promptable masks as the foundation model for extracting task-relevant features, and employ parameter-efficient fine-tuning on robot data for a better understanding of embodied scenarios. To address long-horizon reasoning, we develop a novel multi-channel heatmap that enables the prediction of the action sequence in a single pass, notably enhancing execution efficiency. Experimental results from various instruction-following tasks demonstrate that SAM-E achieves superior performance with higher execution efficiency compared to the baselines, and also significantly improves generalization in few-shot adaptation to new tasks.

  • 8 authors
·
May 29, 2024

A Vision-Language Foundation Model for Zero-shot Clinical Collaboration and Automated Concept Discovery in Dermatology

Medical foundation models have shown promise in controlled benchmarks, yet widespread deployment remains hindered by reliance on task-specific fine-tuning. Here, we introduce DermFM-Zero, a dermatology vision-language foundation model trained via masked latent modelling and contrastive learning on over 4 million multimodal data points. We evaluated DermFM-Zero across 20 benchmarks spanning zero-shot diagnosis and multimodal retrieval, achieving state-of-the-art performance without task-specific adaptation. We further evaluated its zero-shot capabilities in three multinational reader studies involving over 1,100 clinicians. In primary care settings, AI assistance enabled general practitioners to nearly double their differential diagnostic accuracy across 98 skin conditions. In specialist settings, the model significantly outperformed board-certified dermatologists in multimodal skin cancer assessment. In collaborative workflows, AI assistance enabled non-experts to surpass unassisted experts while improving management appropriateness. Finally, we show that DermFM-Zero's latent representations are interpretable: sparse autoencoders unsupervisedly disentangle clinically meaningful concepts that outperform predefined-vocabulary approaches and enable targeted suppression of artifact-induced biases, enhancing robustness without retraining. These findings demonstrate that a foundation model can provide effective, safe, and transparent zero-shot clinical decision support.

  • 31 authors
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Feb 10

Toward a foundation model for forest point clouds

Forest inventories increasingly rely on artificial intelligence (AI) models to derive forest attributes from large-scale 3D point clouds. Current models are typically specialized to a single task, sensor, and forest type, making adaptation expensive in terms of annotations, computation, and expertise. We ask whether a single pretrained model can instead learn transferable representations across diverse forest inventory settings. Inspired by recent developments in language modelling and computer vision, we take a step toward a foundation model (FM) for 3D forestry. Using LitePT as backbone, we first establish a strong supervised baseline that sets a new state of the art on forest semantic and instance segmentation, tree species classification, and age regression benchmarks. We then curate a large-scale unlabelled corpus spanning airborne, UAV, and mobile laser scanning across diverse forest ecosystems, and pretrain the same backbone using self-supervised learning. We systematically evaluate representation learning strategies by comparing training from scratch, supervised pretraining, and self-supervised pretraining across four representative forestry tasks, under varying annotation budgets. Compared with training from scratch, self-supervised pretraining accelerates model convergence and consistently improves performance when annotations are scarce. Compared with task-specific supervised pretraining, self-supervised pretraining yields more transferable representations across downstream forestry tasks. These findings identify the practical regime in which pretrained representations are most valuable and suggest that instance discrimination, rather than forest semantics, is the main remaining obstacle to a general-purpose 3D forest foundation model. Code and models are available at: https://github.com/prs-eth/ForPT.

  • 10 authors
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Sep 20

GreenWAM: A World Foundation Model for Robotics

A robot needs a world model that predicts how its actions will change the scene and a policy that chooses those actions. Models are usually built and evaluated for only one of these roles, and every robot records its actions in its own format. We ask whether one robot world model can serve both roles across different bodies, and what makes this work. We present GreenWAM, a world foundation model for robotics, together with the recipe that produces it: (1) a shared anatomical action space that describes 20 robot families, from bimanual arms to dexterous humanoids, in common joint coordinates; (2) joint training on these families in visual, action-conditioned and world-action modes; and (3) policies that split an action expert off the generator. As a world model, GreenWAM attains top-tier trajectory, depth and 3D accuracy on WorldArena 1.0, ahead of every world-action model and video generator in our comparison. As a policy, it scores among the top entries of the RoboTwin 2.0 leaderboard, reaches the highest zero-shot LIBERO-plus success among the compared methods and is competitive with dedicated vision-language-action and world-action policies on CALVIN and LIBERO. We further adapt GreenWAM to a real humanoid, where it succeeds more often than policies adapted from π_{0.5} and from Cosmos 3 Edge, and distill it into a single-step policy for real-time control. Controlled experiments yield three findings: robot specialization improves world prediction and control together; an action expert helps when split off at the start of adaptation; and keeping world-model modes during policy adaptation preserves robustness to scene changes.

One Language-Free Foundation Model Is Enough for Universal Vision Anomaly Detection

Universal visual anomaly detection (AD) aims to identify anomaly images and segment anomaly regions towards open and dynamic scenarios, following zero- and few-shot paradigms without any dataset-specific fine-tuning. We have witnessed significant progress in widely use of visual-language foundational models in recent approaches. However, current methods often struggle with complex prompt engineering, elaborate adaptation modules, and challenging training strategies, ultimately limiting their flexibility and generality. To address these issues, this paper rethinks the fundamental mechanism behind visual-language models for AD and presents an embarrassingly simple, general, and effective framework for Universal vision Anomaly Detection (UniADet). Specifically, we first find language encoder is used to derive decision weights for anomaly classification and segmentation, and then demonstrate that it is unnecessary for universal AD. Second, we propose an embarrassingly simple method to completely decouple classification and segmentation, and decouple cross-level features, i.e., learning independent weights for different tasks and hierarchical features. UniADet is highly simple (learning only decoupled weights), parameter-efficient (only 0.002M learnable parameters), general (adapting a variety of foundation models), and effective (surpassing state-of-the-art zero-/few-shot by a large margin and even full-shot AD methods for the first time) on 14 real-world AD benchmarks covering both industrial and medical domains. We will make the code and model of UniADet available at https://github.com/gaobb/UniADet.

  • 2 authors
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Jan 9

Toward Efficient Language Model Pretraining and Downstream Adaptation via Self-Evolution: A Case Study on SuperGLUE

This technical report briefly describes our JDExplore d-team's Vega v2 submission on the SuperGLUE leaderboard. SuperGLUE is more challenging than the widely used general language understanding evaluation (GLUE) benchmark, containing eight difficult language understanding tasks, including question answering, natural language inference, word sense disambiguation, coreference resolution, and reasoning. [Method] Instead of arbitrarily increasing the size of a pretrained language model (PLM), our aim is to 1) fully extract knowledge from the input pretraining data given a certain parameter budget, e.g., 6B, and 2) effectively transfer this knowledge to downstream tasks. To achieve goal 1), we propose self-evolution learning for PLMs to wisely predict the informative tokens that should be masked, and supervise the masked language modeling (MLM) process with rectified smooth labels. For goal 2), we leverage the prompt transfer technique to improve the low-resource tasks by transferring the knowledge from the foundation model and related downstream tasks to the target task. [Results] According to our submission record (Oct. 2022), with our optimized pretraining and fine-tuning strategies, our 6B Vega method achieved new state-of-the-art performance on 4/8 tasks, sitting atop the SuperGLUE leaderboard on Oct. 8, 2022, with an average score of 91.3.

  • 14 authors
·
Dec 4, 2022

Text2Earth: Unlocking Text-driven Remote Sensing Image Generation with a Global-Scale Dataset and a Foundation Model

Generative foundation models have advanced large-scale text-driven natural image generation, becoming a prominent research trend across various vertical domains. However, in the remote sensing field, there is still a lack of research on large-scale text-to-image (text2image) generation technology. Existing remote sensing image-text datasets are small in scale and confined to specific geographic areas and scene types. Besides, existing text2image methods have struggled to achieve global-scale, multi-resolution controllable, and unbounded image generation. To address these challenges, this paper presents two key contributions: the Git-10M dataset and the Text2Earth foundation model. Git-10M is a global-scale image-text dataset comprising 10 million image-text pairs, 5 times larger than the previous largest one. The dataset covers a wide range of geographic scenes and contains resolution information, significantly surpassing existing datasets in both size and diversity. Building on Git-10M, we propose Text2Earth, a 1.3 billion parameter generative foundation model based on the diffusion framework to model global-scale remote sensing scenes. Text2Earth integrates a resolution guidance mechanism, enabling users to specify image resolutions. A dynamic condition adaptation strategy is proposed for training and inference to improve image quality. Text2Earth excels in zero-shot text2image generation and demonstrates robust generalization and flexibility across multiple tasks, including unbounded scene construction, image editing, and cross-modal image generation. This robust capability surpasses previous models restricted to the basic fixed size and limited scene types. On the previous benchmark dataset, Text2Earth outperforms previous models with an improvement of +26.23 FID and +20.95% Zero-shot Cls-OA metric.Our project page is https://chen-yang-liu.github.io/Text2Earth

  • 5 authors
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Jan 1, 2025

BehaveGPT: A Foundation Model for Large-scale User Behavior Modeling

In recent years, foundational models have revolutionized the fields of language and vision, demonstrating remarkable abilities in understanding and generating complex data; however, similar advances in user behavior modeling have been limited, largely due to the complexity of behavioral data and the challenges involved in capturing intricate temporal and contextual relationships in user activities. To address this, we propose BehaveGPT, a foundational model designed specifically for large-scale user behavior prediction. Leveraging transformer-based architecture and a novel pretraining paradigm, BehaveGPT is trained on vast user behavior datasets, allowing it to learn complex behavior patterns and support a range of downstream tasks, including next behavior prediction, long-term generation, and cross-domain adaptation. Our approach introduces the DRO-based pretraining paradigm tailored for user behavior data, which improves model generalization and transferability by equitably modeling both head and tail behaviors. Extensive experiments on real-world datasets demonstrate that BehaveGPT outperforms state-of-the-art baselines, achieving more than a 10% improvement in macro and weighted recall, showcasing its ability to effectively capture and predict user behavior. Furthermore, we measure the scaling law in the user behavior domain for the first time on the Honor dataset, providing insights into how model performance scales with increased data and parameter sizes.

  • 8 authors
·
May 23, 2025

Monroe: A Molecular Foundation Model for In-Context Probabilistic Inference

Bioassay activity prediction is often data-limited because drug-discovery datasets rely on time-consuming and expensive wet-lab experiments for data generation and evaluation. This challenge has inspired recent research into molecular foundation models (MFMs), which aim to encode general-purpose chemical knowledge into molecular representations that generalize well in data-constrained scenarios. This paper presents Monroe, a new MFM with several innovations over the existing state of the art: increased scale allowing pre-training on over 81 million molecules from the PM6 quantum chemistry dataset; improved graph representation of stereochemistry; improved training losses including conformer denoising and embedding decorrelation; improved multi-task learning; and the use of a prior-data-fitted model (TabPFN) for downstream in-context prediction. Our evaluations use a principled pairwise comparison framework that measures statistically significant performance differences. Across established Polaris benchmarks, Monroe matches or exceeds existing MFMs, while on activity cliff benchmarks, designed to assess utility for molecular discovery, it achieves significant improvements over prior methods. Finally, ablation and transfer experiments show that PFN-based downstream predictors also substantially improve two leading existing models, MiniMol and CheMeleon, yielding new state-of-the-art variants we call MiniMol_PFN and CheMeleon_PFN, suggesting that our downstream adaptation strategy generalizes beyond Monroe. Source code is at github.com/blazejba/monroe.

  • 2 authors
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Aug 19

UniTabE: A Universal Pretraining Protocol for Tabular Foundation Model in Data Science

Recent advancements in NLP have witnessed the groundbreaking impact of pretrained models, yielding impressive outcomes across various tasks. This study seeks to extend the power of pretraining methodologies to facilitating the prediction over tables in data science, a domain traditionally overlooked, yet inherently challenging due to the plethora of table schemas intrinsic to different tasks. The primary research questions underpinning this work revolve around the establishment of a universal pretraining protocol for tables with varied structures, the generalizability and transferability of learned knowledge across tasks, the adaptation to diverse downstream applications, and the incorporation of incremental columns over time. In response to these challenges, we introduce UniTabE, a straightforward yet effective method designed to process tables in a uniform manner, devoid of constraints imposed by specific table structures. UniTabE's core concept relies on representing each basic table element with a module, termed TabUnit. This is subsequently followed by a Transformer encoder to refine the representation. Moreover, our model is designed to facilitate pretraining and finetuning through the utilization of free-form prompts. In order to implement the pretraining phase, we curated an expansive tabular dataset comprising approximately 13B samples, meticulously gathered from the Kaggle platform. This research primarily centers on classification and regression tasks involving tabular data, and conducts rigorous experimental testing and analyses to validate the effectiveness of our methodology. The experimental results demonstrate UniTabE's superior performance against several baselines across massive benchmarks. This, therefore, underscores UniTabE's potential to significantly enhance the semantic representation of tabular data, thereby marking a significant stride for tabular data analysis.

  • 5 authors
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Jul 18, 2023

Decipher-MR: A Vision-Language Foundation Model for 3D MRI Representations

Magnetic Resonance Imaging (MRI) is a critical medical imaging modality in clinical diagnosis and research, yet its complexity and heterogeneity pose challenges for automated analysis, particularly in scalable and generalizable machine learning applications. While foundation models have revolutionized natural language and vision tasks, their application to MRI remains limited due to data scarcity and narrow anatomical focus. In this work, we present Decipher-MR, a 3D MRI-specific vision-language foundation model trained on a large-scale dataset comprising 200,000 MRI series from over 22,000 studies spanning diverse anatomical regions, sequences, and pathologies. Decipher-MR integrates self-supervised vision learning with report-guided text supervision to build robust, generalizable representations, enabling effective adaptation across broad applications. To enable robust and diverse clinical tasks with minimal computational overhead, Decipher-MR supports a modular design that enables tuning of lightweight, task-specific decoders attached to a frozen pretrained encoder. Following this setting, we evaluate Decipher-MR across diverse benchmarks including disease classification, demographic prediction, anatomical localization, and cross-modal retrieval, demonstrating consistent performance gains over existing foundation models and task-specific approaches. Our results establish Decipher-MR as a scalable and versatile foundation for MRI-based AI, facilitating efficient development across clinical and research domains.

  • 14 authors
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Sep 25, 2025

UMO: Unified In-Context Learning Unlocks Motion Foundation Model Priors

Large-scale foundation models (LFMs) have recently made impressive progress in text-to-motion generation by learning strong generative priors from massive 3D human motion datasets and paired text descriptions. However, how to effectively and efficiently leverage such single-purpose motion LFMs, i.e., text-to-motion synthesis, in more diverse cross-modal and in-context motion generation downstream tasks remains largely unclear. Prior work typically adapts pretrained generative priors to individual downstream tasks in a task-specific manner. In contrast, our goal is to unlock such priors to support a broad spectrum of downstream motion generation tasks within a single unified framework. To bridge this gap, we present UMO, a simple yet general unified formulation that casts diverse downstream tasks into compositions of atomic per-frame operations, enabling in-context adaptation to unlock the generative priors of pretrained DiT-based motion LFMs. Specifically, UMO introduces three learnable frame-level meta-operation embeddings to specify per-frame intent and employs lightweight temporal fusion to inject in-context cues into the pretrained backbone, with negligible runtime overhead compared to the base model. With this design, UMO finetunes the pretrained model, originally limited to text-to-motion generation, to support diverse previously unsupported tasks, including temporal inpainting, text-guided motion editing, text-serialized geometric constraints, and multi-identity reaction generation. Experiments demonstrate that UMO consistently outperforms task-specific and training-free baselines across a wide range of benchmarks, despite using a single unified model. Code and model will be publicly available. Project Page: https://oliver-cong02.github.io/UMO.github.io/

  • 12 authors
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Mar 16

TouchWorld: A Predictive and Reactive Tactile Foundation Model for Dexterous Manipulation

Dexterous manipulation in everyday environments requires both anticipation and reaction: a robot must predict how contact should evolve while rapidly correcting local errors caused by slip, misalignment, unstable grasping, or force mismatch. Vision and language provide semantic and geometric guidance, but they cannot reliably reveal hidden contact states such as force, slip, and contact stability. Although tactile sensing exposes these physical cues, most existing policies treat touch as a low-frequency observation stream within a monolithic action model, coupling slow task reasoning, action generation, and fast contact feedback in a single loop. We introduce TouchWorld, a predictive-and-reactive tactile foundation model for dexterous manipulation. TouchWorld uses a hierarchical policy that separates vision-language subtask planning, tactile world-model prediction, visuo-tactile goal-conditioned action generation, and high-frequency tactile residual refinement. A High-Level Planning Layer produces executable subtasks and predicts tactile subgoals; a Visuo-Tactile Goal-Conditioned Policy generates nominal action chunks; and a Tactile-Conditioned Refinement Policy performs online residual correction using recent tactile and proprioceptive feedback. By using touch as both a predictive contact reference and a fast feedback signal, TouchWorld preserves the semantic generalization of vision-language-action policies while improving local contact adaptation. Across six long-horizon and contact-rich dexterous manipulation tasks, TouchWorld achieves 65.0% success in the clean setting and 53.7% success under human perturbations, outperforming the strongest baseline by 15.7 and 18.5 percentage points, respectively.

  • 12 authors
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Jul 7

Delineate Anything v2: A Global Foundation Model for Field Delineation

Accurate agricultural field boundary delineation at large scale is a foundational task for food security, supply chain transparency, and carbon accounting. While vision foundation models like SAM show remarkable zero-shot capabilities, they frequently fail in geospatial domains due to topological complexity, cropland texturing patterns, and a lack of physical scale awareness. In this work, we introduce Delineate Anything v2, a globally scalable foundation model designed specifically for wide-area field boundary mapping. We construct FBIS-73M, a 73-million-instance multi-resolution dataset spanning 61 countries. To address the pervasive issue of multi-field administrative parcel merging, we introduce a resolution-specific data curation pipeline that leverages topological image-space adaptation to homogenize merged parcels and strengthen weak physical boundaries. Furthermore, we establish a novel, manually curated evaluation benchmark covering 100 countries to assess independent zero-shot generalization. Our results show that Delineate Anything v2 surpasses the current state-of-the-art, including the Delineate Anything framework, by 0.284 mAP@0.5 (+103.3% relative gain), while maintaining execution speeds suitable for rapid national- and global-scale deployment, as demonstrated by nationwide mapping of Ukraine (603,000 km^2) in 5.4 hours on a consumer-grade workstation. Code, pre-trained weights, the FBIS-73M dataset, and ready-to-use national-scale vector boundary products are publicly available at https://github.com/Lavreniuk/Delineate-Anything.

  • 7 authors
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Jul 20 2

AI for Games in the Foundation Model Era

Foundation models, alongside advances in learned game-world models, are reshaping AI across the game lifecycle. Beyond playing games, recent systems model players and game dynamics, support design and development, adapt player-facing experiences at runtime, and evaluate resulting artifacts. Yet these directions have evolved largely separately, obscuring which capabilities transfer across settings and which remain tied to particular games, engines, interfaces, or player populations. We organize the literature into six roles according to the immediate use of AI output: playing and acting; modeling players and games; designing games; building and maintaining games; generating and adapting at runtime; and testing and evaluating games. For each role, we examine what structure is supplied by the game or workflow, what AI learns or produces, which capabilities and artifacts transfer across settings and roles, and what evidence supports the claims. We identify cross-role connections: trajectories train world models, learned environments provide experience for agents, design specifications drive executable implementations, and play or testing feedback guides revision. However, control schemes, rules, engine interfaces, state representations, and player contexts often remain setting-specific, so downstream claims require validation in the target setting. Evaluation is most standardized for bounded game playing and selected learned environments, while persistent state in learned worlds, repeated software revision, validated player modeling, sustained runtime adaptation, and representative automated testing remain less established. The central challenge is to reuse or transfer outputs and capabilities across roles while re-establishing evidence for effectiveness in the game-specific contexts where they are used.

Magic-W0: A Structured World-Action Foundation Model for Physical Intelligence

World-action models (WAMs) augment robot policies with action-conditioned environment dynamics, yet existing approaches largely rely on future observation reconstruction or generic latent prediction and lack structured, control-oriented world representations tightly coupled with action generation. We introduce Magic-W0, a world-action foundation model that jointly models structured physical state evolution and continuous actions. Magic-W0 represents interaction as a Structured World Transition consisting of Current State, Transition, and Future State. Current State combines vision-language context with Current 3D Geometry; Transition is represented by 3D Motion capturing action-induced three-dimensional changes; and Future State is represented by Future Semantics describing task-relevant outcomes. To couple prediction and control, we propose a layer-aligned world-action interaction architecture in which evolving action hypotheses condition world-transition prediction, while predicted world representations continuously inform action generation. Magic-W0 is pre-trained on large-scale egocentric human manipulation, UMI, real-robot, and simulation data, with latent supervision for geometry, 3D motion, and future semantics from pre-trained visual models. Inference-time interventions show that structured world representations respond systematically to changes in candidate actions and that action-related information propagates through shared 3D representations into future semantic predictions. On RoboDojo-Sim, Magic-W0 achieves an average Score of 27.10, the highest among the compared WAMs. Across multiple real-robot tasks, it also demonstrates strong downstream performance after fine-tuning with limited downstream data, supporting generalization and rapid adaptation.

  • 18 authors
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Oct 2 1

BFM-Zero: A Promptable Behavioral Foundation Model for Humanoid Control Using Unsupervised Reinforcement Learning

Building Behavioral Foundation Models (BFMs) for humanoid robots has the potential to unify diverse control tasks under a single, promptable generalist policy. However, existing approaches are either exclusively deployed on simulated humanoid characters, or specialized to specific tasks such as tracking. We propose BFM-Zero, a framework that learns an effective shared latent representation that embeds motions, goals, and rewards into a common space, enabling a single policy to be prompted for multiple downstream tasks without retraining. This well-structured latent space in BFM-Zero enables versatile and robust whole-body skills on a Unitree G1 humanoid in the real world, via diverse inference methods, including zero-shot motion tracking, goal reaching, and reward optimization, and few-shot optimization-based adaptation. Unlike prior on-policy reinforcement learning (RL) frameworks, BFM-Zero builds upon recent advancements in unsupervised RL and Forward-Backward (FB) models, which offer an objective-centric, explainable, and smooth latent representation of whole-body motions. We further extend BFM-Zero with critical reward shaping, domain randomization, and history-dependent asymmetric learning to bridge the sim-to-real gap. Those key design choices are quantitatively ablated in simulation. A first-of-its-kind model, BFM-Zero establishes a step toward scalable, promptable behavioral foundation models for whole-body humanoid control.

  • 13 authors
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Nov 6, 2025

Coupling Perception and Reasoning in Federated Multimodal Graph Foundation Models

Federated multimodal graph foundation models (GFMs) aim to adapt pretrained multimodal models to decentralized graph data, where each client owns a private multimodal graph and cannot share raw information. These models typically combine a multimodal Encoder that extracts semantic evidence from heterogeneous modalities and a graph neural network (GNN) that performs relational reasoning over graph structures. However, existing federated GFM adaptation methods mainly update graph-side modules while keeping the multimodal Encoder frozen, limiting adaptation to how information is propagated while fixing what information is extracted. Through empirical studies, we reveal that Encoder and GNN adaptations are not independent: Encoder adaptation is affected by graph relations, while cross-client module swapping reveals substantial pairing sensitivity between separately parameterized Encoder and GNN updates. Motivated by this observation, we propose FedCORE, a federated adaptation framework that represents Encoder and GNN updates through a shared low-dimensional latent state. FedCORE jointly optimizes this core from multimodal and structural signals and performs federated evolution directly in the shared state space, preserving compatibility between perception and reasoning adaptations. Extensive experiments demonstrate that FedCORE reduces the Encoder--GNN pairing gap from 30.6 to 5.9, corresponding to an 80.7% reduction over independent joint adaptation.

  • 10 authors
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Sep 23

A data- and compute-efficient chest X-ray foundation model beyond aggressive scaling

Foundation models for medical imaging are typically pretrained on increasingly large datasets, following a "scale-at-all-costs" paradigm. However, this strategy faces two critical challenges: large-scale medical datasets often contain substantial redundancy and severe class imbalance that bias representation learning toward over-represented patterns, and indiscriminate training regardless of heterogeneity in data quality incurs considerable computational inefficiency. Here we demonstrate that active, principled data curation during pretraining can serve as a viable, cost-effective alternative to brute-force dataset enlargement. We introduce CheXficient, a chest X-ray (CXR) foundation model that selectively prioritizes informative training samples. CheXficient is pretrained on only 22.7% of 1,235,004 paired CXR images and reports while consuming under 27.3% of the total compute budget, yet achieving comparable or superior performance to its full-data counterpart and other large-scale pretrained models. We assess CheXficient across 20 individual benchmarks spanning 5 task types, including non-adapted off-the-shelf evaluations (zero-shot findings classification and crossmodal retrieval) and adapted downstream tasks (disease prediction, semantic segmentation, and radiology report generation). Further analyses show that CheXficient systematically prioritizes under-represented training samples, improving generalizability on long-tailed or rare conditions. Overall, our work offers practical insights into the data and computation demands for efficient pretraining and downstream adaptation of medical vision-language foundation models.

  • 12 authors
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Feb 26

NodeGround: A Node Classification Benchmark in the Graph Foundation Model Era

Can a pretrained graph model replace training and tuning a separate predictor for each dataset? Answering this requires evaluating prediction quality alongside computational cost. We present NodeGround, a node classification benchmark that puts graph foundation models (GFMs) and dataset-specific supervised learning under a common evaluation framework. The benchmark spans 51 datasets and evaluates six GFMs alongside 15 supervised methods under two label-availability regimes. Shared data partitions, validation-only model selection, controlled hyperparameter searches, and multiple predictive metrics make comparisons systematic, while workflow measurements account for adaptation, training, tuning, and inference. The results favor carefully tuned graph neural networks overall. GraphPFN reaches third place by Elo when more labels are available, yet its relative strengths vary substantially with dataset properties. Efficiency comparisons further qualify the benefits of pretrained reuse: GVT and GraphPFN appear on the Pareto frontiers when supervised methods are represented by their default and fully tuned configurations. Adding intermediate tuning budgets removes this advantage for GVT and leaves GraphPFN extending the estimated frontier in the label-rich setting alone. Thus, reusing pretrained parameters does not yet provide a broadly reliable route to either stronger predictions or cheaper workflows. We release the evaluation pipeline, run-level records, and an open leaderboard at https://github.com/nums-ai/nodeground.

  • 4 authors
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Sep 29

Pretrain Once, Route Anywhere: Towards a Foundation Model for LLM Routing

Large language model (LLM) routing aims to assign each query to the most suitable model from a heterogeneous candidate pool, improving the quality--efficiency trade-off of LLM inference. Existing routers are typically learned through local fitting: a router is optimized for a particular query workload and candidate pool, and often requires additional supervision or retraining as the routing environment changes. We ask whether LLM routing can instead be approached from a foundation-model perspective, learning a reusable routing capability that generalizes across tasks, candidate models, and deployment conditions. To this end, we introduce RouteFM, which learns to characterize anonymous candidate models from behavioral context and infer their target-specific capabilities, rather than binding routing decisions to fixed model identities or a single environment. Through episodic pretraining across heterogeneous routing environments, this capability can be reused by a frozen router and adapted to new environments through context alone. Experiments demonstrate transfer across changes in domains, modalities, candidate pools, and context budgets, with the largest gains when behavioral evidence is limited. On MMR-Bench, which is excluded from pretraining, RouteFM outperforms the strongest baseline by 2.23 quality points with only eight observations per candidate. These results support moving LLM routing from repeated local fitting toward a pretrain once, route anywhere paradigm. Our code is publicly available at https://github.com/LAMDA-Model-Reuse/RouteFM.

Leveraging Generic Foundation Models for Multimodal Surgical Data Analysis

We investigate how both the adaptation of a generic foundation model via transfer learning and the integration of complementary modalities from the operating room (OR) can support surgical data science. To this end, we use V-JEPA as the single-modality foundation of a multimodal model for minimally invasive surgery support. We analyze how the model's downstream performance can benefit (a) from finetuning on unlabeled surgical video data and (b) from providing additional time-resolved data streams from the OR in a multimodal setup. In an in-house dataset of liver surgery videos, we analyze the tasks of predicting hospital length of stay and postoperative complications. In videos of the public HeiCo dataset, we analyze the task of surgical phase recognition. As a baseline, we apply pretrained V-JEPA to all tasks. We then finetune it on unlabeled, held-out videos to investigate its change in performance after domain adaptation. Following the idea of modular decision support networks, we integrate additional data streams from the OR by training a separate encoder to form a shared representation space with V-JEPA's embeddings. Our experiments show that finetuning on domain-specific data increases model performance. On the in-house data, integrating additional time-resolved data likewise benefits the model. On the HeiCo data, accuracy of the pretrained video-only, single-modality baseline setup is on par with the top-performing submissions of the EndoVis2017 challenge, while finetuning on domain-specific data increases accuracy further. Our results thus demonstrate how surgical data science can leverage public, generic foundation models. Likewise, they indicate the potential of domain adaptation and of integrating suitable complementary data streams from the OR. To support further research, we release our code and model weights at https://github.com/DigitalSurgeryLab-Basel/ML-CDS-2025.

  • 5 authors
·
Sep 8, 2025

Learning to Efficiently Adapt Foundation Models for Self-Supervised Endoscopic 3D Scene Reconstruction from Any Cameras

Accurate 3D scene reconstruction is essential for numerous medical tasks. Given the challenges in obtaining ground truth data, there has been an increasing focus on self-supervised learning (SSL) for endoscopic depth estimation as a basis for scene reconstruction. While foundation models have shown remarkable progress in visual tasks, their direct application to the medical domain often leads to suboptimal results. However, the visual features from these models can still enhance endoscopic tasks, emphasizing the need for efficient adaptation strategies, which still lack exploration currently. In this paper, we introduce Endo3DAC, a unified framework for endoscopic scene reconstruction that efficiently adapts foundation models. We design an integrated network capable of simultaneously estimating depth maps, relative poses, and camera intrinsic parameters. By freezing the backbone foundation model and training only the specially designed Gated Dynamic Vector-Based Low-Rank Adaptation (GDV-LoRA) with separate decoder heads, Endo3DAC achieves superior depth and pose estimation while maintaining training efficiency. Additionally, we propose a 3D scene reconstruction pipeline that optimizes depth maps' scales, shifts, and a few parameters based on our integrated network. Extensive experiments across four endoscopic datasets demonstrate that Endo3DAC significantly outperforms other state-of-the-art methods while requiring fewer trainable parameters. To our knowledge, we are the first to utilize a single network that only requires surgical videos to perform both SSL depth estimation and scene reconstruction tasks. The code will be released upon acceptance.

  • 11 authors
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Mar 20, 2025

Test-Time Compute for Tabular Foundation Models: Mechanisms, Gains, and Limits

Which forms of test-time compute improve the predictions of strong pretrained tabular foundation models (TFMs)? We systematically study this along three axes: adaptation, aggregation, and context construction. Our evaluation spans modern TFMs across the TabArena benchmark, supplemented by experiments on wide and large-scale tables from OpenML. For adaptation, we introduce DiagScale, a diagonal query-key similarity update. It trains only 0.003-0.03% of model parameters and achieves gains comparable to full fine-tuning across three independently pretrained backbones. For aggregation, both pool composition and selection strategy matter. TabPFN-3 already averages predictions from different preprocessing variants of the same data, and adding more such predictions yields diminishing returns. With a broader pool of 96 configurations, greedy selection reduces error by 2.4% relative to the default predictor, but uniform averaging increases error. For context construction, attention-guided retrieval improves TabPFN-3's predictions on some large tables and supports source pools beyond the full context memory limit. The context expansion methods we test yield no consistent improvement. Taken together, our results suggest that adaptation and selective aggregation yield consistent benchmark-level gains. The benefits of context construction depend more on the task and data regime. Adaptation and aggregation over the same backbone yield further gains when combined, but require substantially more computation than default inference. These trade-offs motivate choosing strategies according to the available computation budget. Code is available at https://github.com/kanghui-learning/test-time-compute-for-tabular-foundation-models.

  • 8 authors
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Oct 7

OSM-based Domain Adaptation for Remote Sensing VLMs

Vision-Language Models (VLMs) adapted to remote sensing rely heavily on domain-specific image-text supervision, yet high-quality annotations for satellite and aerial imagery remain scarce and expensive to produce. Prevailing pseudo-labeling pipelines address this gap by distilling knowledge from large frontier models, but this dependence on large teachers is costly, limits scalability, and caps achievable performance at the ceiling of the teacher. We propose OSMDA: a self-contained domain adaptation framework that eliminates this dependency. Our key insight is that a capable base VLM can serve as its own annotation engine: by pairing aerial images with rendered OpenStreetMap (OSM) tiles, we leverage optical character recognition and chart comprehension capabilities of the model to generate captions enriched by OSM's vast auxiliary metadata. The model is then fine-tuned on the resulting corpus with satellite imagery alone, yielding OSMDA-VLM, a domain-adapted VLM that requires no manual labeling and no stronger external model. We conduct exhaustive evaluations spanning 10 benchmarks across image-text-to-text tasks and comparing against 9 competitive baselines. When equally mixed with real data, our method achieves state-of-the-art results, while being substantially cheaper to train than teacher-dependent alternatives. These results suggest that, given a strong foundation model, alignment with crowd-sourced geographic data is a practical and scalable path towards remote sensing domain adaptation. Dataset and model weights will be made publicly available.

Search over Self-Edit Strategies for LLM Adaptation

Many LLM-based open-ended search systems freeze the foundation model that proposes improvements to existing solutions, which may bottleneck long-run progress. Recent work has explored updating the proposal model at test time [arXiv:2511.23473], but the update strategy is still typically hand-specified. Therefore, this study investigated whether an LLM can use task feedback to decide how it should update its weights. For tractability, we focused on the simpler case where there is only one round of self-improvement, and restricted the update operator to self-supervised next token prediction (NTP), leaving the model freedom in choosing its training data and key NTP hyperparameters. Using the Self-Adapting Language Models (SEAL) [arXiv:2506.10943] framework as a testbed, we relaxed its fixed human template constraint and allowed the model to generate its own self-edit templates, thereby giving it more control over its training data and hyperparameters. Two variants were studied, differing in whether template generation was conditioned on a lightweight archive of past templates. In SEAL's Single-Passage Knowledge Incorporation setting with Qwen3-8B on SQuAD [arXiv:1606.05250], the no-archive variant performed comparably to the weaker "Implications" baseline, while the archive variant outperformed "Implications" and approached the strongest human-designed "Rewrite" baseline without surpassing it. Further analysis of collapse in the model's exploration revealed that a naive archive can confer some short-term robustness but can also accelerate homogenization, suggesting that explicit novelty pressure may be required to consistently advance beyond carefully optimized human strategies. Our code is available at https://github.com/cheongalc/search-self-edit-strategies .

  • 4 authors
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Jan 19

OpenMEDLab: An Open-source Platform for Multi-modality Foundation Models in Medicine

The emerging trend of advancing generalist artificial intelligence, such as GPTv4 and Gemini, has reshaped the landscape of research (academia and industry) in machine learning and many other research areas. However, domain-specific applications of such foundation models (e.g., in medicine) remain untouched or often at their very early stages. It will require an individual set of transfer learning and model adaptation techniques by further expanding and injecting these models with domain knowledge and data. The development of such technologies could be largely accelerated if the bundle of data, algorithms, and pre-trained foundation models were gathered together and open-sourced in an organized manner. In this work, we present OpenMEDLab, an open-source platform for multi-modality foundation models. It encapsulates not only solutions of pioneering attempts in prompting and fine-tuning large language and vision models for frontline clinical and bioinformatic applications but also building domain-specific foundation models with large-scale multi-modal medical data. Importantly, it opens access to a group of pre-trained foundation models for various medical image modalities, clinical text, protein engineering, etc. Inspiring and competitive results are also demonstrated for each collected approach and model in a variety of benchmarks for downstream tasks. We welcome researchers in the field of medical artificial intelligence to continuously contribute cutting-edge methods and models to OpenMEDLab, which can be accessed via https://github.com/openmedlab.

  • 20 authors
·
Feb 27, 2024

PUSA V1.0: Surpassing Wan-I2V with $500 Training Cost by Vectorized Timestep Adaptation

The rapid advancement of video diffusion models has been hindered by fundamental limitations in temporal modeling, particularly the rigid synchronization of frame evolution imposed by conventional scalar timestep variables. While task-specific adaptations and autoregressive models have sought to address these challenges, they remain constrained by computational inefficiency, catastrophic forgetting, or narrow applicability. In this work, we present Pusa, a groundbreaking paradigm that leverages vectorized timestep adaptation (VTA) to enable fine-grained temporal control within a unified video diffusion framework. Besides, VTA is a non-destructive adaptation, which means it fully preserves the capabilities of the base model. By finetuning the SOTA Wan2.1-T2V-14B model with VTA, we achieve unprecedented efficiency -- surpassing the performance of Wan-I2V-14B with leq 1/200 of the training cost (\500 vs. \geq 100,000) and leq 1/2500 of the dataset size (4K vs. geq 10M samples). Pusa not only sets a new standard for image-to-video (I2V) generation, achieving a VBench-I2V total score of 87.32\% (vs. 86.86\% of Wan-I2V-14B), but also unlocks many zero-shot multi-task capabilities such as start-end frames and video extension -- all without task-specific training. Meanwhile, Pusa can still perform text-to-video generation. Mechanistic analyses reveal that our approach preserves the foundation model's generative priors while surgically injecting temporal dynamics, avoiding the combinatorial explosion inherent to vectorized timesteps. This work establishes a scalable, efficient, and versatile paradigm for next-generation video synthesis, democratizing high-fidelity video generation for research and industry alike. Code is open-sourced at https://github.com/Yaofang-Liu/Pusa-VidGen

  • 12 authors
·
Jul 21, 2025 1

UrFound: Towards Universal Retinal Foundation Models via Knowledge-Guided Masked Modeling

Retinal foundation models aim to learn generalizable representations from diverse retinal images, facilitating label-efficient model adaptation across various ophthalmic tasks. Despite their success, current retinal foundation models are generally restricted to a single imaging modality, such as Color Fundus Photography (CFP) or Optical Coherence Tomography (OCT), limiting their versatility. Moreover, these models may struggle to fully leverage expert annotations and overlook the valuable domain knowledge essential for domain-specific representation learning. To overcome these limitations, we introduce UrFound, a retinal foundation model designed to learn universal representations from both multimodal retinal images and domain knowledge. UrFound is equipped with a modality-agnostic image encoder and accepts either CFP or OCT images as inputs. To integrate domain knowledge into representation learning, we encode expert annotation in text supervision and propose a knowledge-guided masked modeling strategy for model pre-training. It involves reconstructing randomly masked patches of retinal images while predicting masked text tokens conditioned on the corresponding retinal image. This approach aligns multimodal images and textual expert annotations within a unified latent space, facilitating generalizable and domain-specific representation learning. Experimental results demonstrate that UrFound exhibits strong generalization ability and data efficiency when adapting to various tasks in retinal image analysis. By training on ~180k retinal images, UrFound significantly outperforms the state-of-the-art retinal foundation model trained on up to 1.6 million unlabelled images across 8 public retinal datasets. Our code and data are available at https://github.com/yukkai/UrFound.

  • 8 authors
·
Aug 10, 2024

Foundation Models for Event Prediction Across Heterogeneous Event Logs

Event logs are ubiquitous across real-world domains, including business processes, manufacturing workflows, healthcare, and many other operational systems. Yet event logs can differ substantially in their event semantics, label spaces, interaction patterns, and temporal scales, making it difficult to build a single foundation model that generalizes directly to previously unseen systems. We address this challenge with the Foundation Event Predictor (FEP), a simple and scalable in-context architecture that performs next-event prediction through learned, event-level nonparametric inference. Causal self-attention encodes context and target histories into key and query representations, respectively, while the observed next context events are encoded as values. Cross-attention then performs learned, relevance-weighted aggregation of next-event outcomes over all context transitions, allowing the entire nonparametric prediction procedure to be expressed as standard attention operations and efficiently parallelized with modern kernels such as FlashAttention. To promote cross-system generalization, we introduce permutation-robust embedding learning and random fixed embeddings to decouple event IDs from persistent semantics, together with empirical quantile transforms and robust normalization to handle diverse temporal scales. We pretrain FEP on 696 real-world event datasets spanning heterogeneous event systems and evaluate it on 50 held-out datasets unseen during pretraining. Across these datasets, FEP generalizes effectively to new event systems without parameter adaptation, frequently approaching the performance of strong models trained separately on each target dataset while substantially outperforming existing foundation-model baselines, particularly on challenging prediction tasks.

  • 4 authors
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Oct 12

PathAsst: A Generative Foundation AI Assistant Towards Artificial General Intelligence of Pathology

As advances in large language models (LLMs) and multimodal techniques continue to mature, the development of general-purpose multimodal large language models (MLLMs) has surged, offering significant applications in interpreting natural images. However, the field of pathology has largely remained untapped, particularly in gathering high-quality data and designing comprehensive model frameworks. To bridge the gap in pathology MLLMs, we present PathAsst, a multimodal generative foundation AI assistant to revolutionize diagnostic and predictive analytics in pathology. The development of PathAsst involves three pivotal steps: data acquisition, CLIP model adaptation, and the training of PathAsst's multimodal generative capabilities. Firstly, we collect over 207K high-quality pathology image-text pairs from authoritative sources. Leveraging the advanced power of ChatGPT, we generate over 180K instruction-following samples. Furthermore, we devise additional instruction-following data specifically tailored for invoking eight pathology-specific sub-models we prepared, allowing the PathAsst to effectively collaborate with these models, enhancing its diagnostic ability. Secondly, by leveraging the collected data, we construct PathCLIP, a pathology-dedicated CLIP, to enhance PathAsst's capabilities in interpreting pathology images. Finally, we integrate PathCLIP with the Vicuna-13b and utilize pathology-specific instruction-tuning data to enhance the multimodal generation capacity of PathAsst and bolster its synergistic interactions with sub-models. The experimental results of PathAsst show the potential of harnessing AI-powered generative foundation model to improve pathology diagnosis and treatment processes.

  • 9 authors
·
May 24, 2023