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Nov 11

Gradient-Normalized Smoothness for Optimization with Approximate Hessians

In this work, we develop new optimization algorithms that use approximate second-order information combined with the gradient regularization technique to achieve fast global convergence rates for both convex and non-convex objectives. The key innovation of our analysis is a novel notion called Gradient-Normalized Smoothness, which characterizes the maximum radius of a ball around the current point that yields a good relative approximation of the gradient field. Our theory establishes a natural intrinsic connection between Hessian approximation and the linearization of the gradient. Importantly, Gradient-Normalized Smoothness does not depend on the specific problem class of the objective functions, while effectively translating local information about the gradient field and Hessian approximation into the global behavior of the method. This new concept equips approximate second-order algorithms with universal global convergence guarantees, recovering state-of-the-art rates for functions with H\"older-continuous Hessians and third derivatives, quasi-self-concordant functions, as well as smooth classes in first-order optimization. These rates are achieved automatically and extend to broader classes, such as generalized self-concordant functions. We demonstrate direct applications of our results for global linear rates in logistic regression and softmax problems with approximate Hessians, as well as in non-convex optimization using Fisher and Gauss-Newton approximations.

  • 3 authors
·
Jun 16, 2025

REX: Revisiting Budgeted Training with an Improved Schedule

Deep learning practitioners often operate on a computational and monetary budget. Thus, it is critical to design optimization algorithms that perform well under any budget. The linear learning rate schedule is considered the best budget-aware schedule, as it outperforms most other schedules in the low budget regime. On the other hand, learning rate schedules -- such as the 30-60-90 step schedule -- are known to achieve high performance when the model can be trained for many epochs. Yet, it is often not known a priori whether one's budget will be large or small; thus, the optimal choice of learning rate schedule is made on a case-by-case basis. In this paper, we frame the learning rate schedule selection problem as a combination of i) selecting a profile (i.e., the continuous function that models the learning rate schedule), and ii) choosing a sampling rate (i.e., how frequently the learning rate is updated/sampled from this profile). We propose a novel profile and sampling rate combination called the Reflected Exponential (REX) schedule, which we evaluate across seven different experimental settings with both SGD and Adam optimizers. REX outperforms the linear schedule in the low budget regime, while matching or exceeding the performance of several state-of-the-art learning rate schedules (linear, step, exponential, cosine, step decay on plateau, and OneCycle) in both high and low budget regimes. Furthermore, REX requires no added computation, storage, or hyperparameters.

  • 3 authors
·
Jul 9, 2021

Analysis of grid instabilities in particle-in-cell codes based on a meshfree approach

A new method of analyzing grid, or aliasing, instabilities is described, in particle-in-cell (PIC) codes for plasma kinetic theory. It starts with a meshfree approach with N_{p} macroparticles, with N_{p}<infty. Linearization of these equations is done about a uniform density non-drifting equilibrium prescribed by macroparticles on a uniform lattice. Macroparticle positions perturbations are induced about this lattice. The resulting linear equations are analyzed for stability and dispersion relations. The linearized equations are then discretized on a grid of N_{g} points with N_{g} le N_{p}, in both momentum conserving (MCP) and energy conserving (ECP) formulations. For a cold stationary plasma, this leads a dynamical matrix. For ECP, the matrix is symmetric and positive definite (SPD) and immediately shows stability. For MCP, the dynamical matrix is neither symmetric nor positive definite, preventing immediate conclusions on stability. For both MCP and ECP and for a cold stationary plasma, the resulting matrix elements vary relative to the meshfree value, a result of aliasing. This deviation is periodic in the displacement of the particle lattice relative to the grid. In the MCP discretization, eigenvalues occur in complex conjugate pairs for general placement of the particle lattice relative to the grid. These conjugate pairs indicate nonnegative growth rates. The nature of the aliasing is studied and shown to be related to the trapezoidal rule error over the grid. The scaling of the linear growth rates with respect to N_{g} and especially with respect to N_{ppc} is studied. These analytical results are compared with PIC simulations and found to be in excellent agreement. The connection with a cold drifting beam is discussed briefly, specifically, grid-induced instabilities for both the MCP and ECP.

  • 2 authors
·
Sep 30

Self-Expansion of Pre-trained Models with Mixture of Adapters for Continual Learning

Continual learning (CL) aims to continually accumulate knowledge from a non-stationary data stream without catastrophic forgetting of learned knowledge, requiring a balance between stability and adaptability. Relying on the generalizable representation in pre-trained models (PTMs), PTM-based CL methods perform effective continual adaptation on downstream tasks by adding learnable adapters or prompts upon the frozen PTMs. However, many existing PTM-based CL methods use restricted adaptation on a fixed set of these modules to avoid forgetting, suffering from limited CL ability. Periodically adding task-specific modules results in linear model growth rate and impaired knowledge reuse. We propose Self-Expansion of pre-trained models with Modularized Adaptation (SEMA), a novel approach to enhance the control of stability-plasticity balance in PTM-based CL. SEMA automatically decides to reuse or add adapter modules on demand in CL, depending on whether significant distribution shift that cannot be handled is detected at different representation levels. We design modular adapter consisting of a functional adapter and a representation descriptor. The representation descriptors are trained as a distribution shift indicator and used to trigger self-expansion signals. For better composing the adapters, an expandable weighting router is learned jointly for mixture of adapter outputs. SEMA enables better knowledge reuse and sub-linear expansion rate. Extensive experiments demonstrate the effectiveness of the proposed self-expansion method, achieving state-of-the-art performance compared to PTM-based CL methods without memory rehearsal. Code is available at https://github.com/huiyiwang01/SEMA-CL.

  • 4 authors
·
Mar 27, 2024

Can Language Models Learn While They Think? Testing Gradient Adaptation Across Architectures

Letting a language model take gradient steps on the text it is reading, known as dynamic evaluation, lowers its loss on the rest of the document. Its behaviour on hybrid linear-attention architectures, on diffusion language models, and on standard long-context benchmarks has not been measured. We measure it. With one SGD step per 128-token chunk on the MLP output projections of the last quarter of blocks, no training, and a 2k-token window, softmax-attention models (Qwen3-1.7B, Qwen3-4B, Gemma-4-E4B) lose 5-8% of their next-token loss over a document and outperform the same frozen model given the full 32k-token context. Hybrid Gated-DeltaNet models (Qwen3.5-4B, Qwen3.8-27B) gain under 1% at every learning rate: the linear-attention blocks already perform the adaptation. The mechanism transfers to masked-diffusion models with a larger effect, 8% on Nemotron-Diffusion-8B and 17-20% on DiffusionGemma-26B, once the rate is lowered and updates are clipped. Across RULER, BABILong, LongBench-v2, SCOTUS, HotpotQA, MuSiQue, ContractNLI and citation completion, at 100 or more items on two model sizes, weights updated on the full document recover none of the accuracy lost to context truncation: the adaptation is style and vocabulary, not retrieval. Writing facts with the next-token loss stores the prompt format rather than the fact (30% recall under chat prompting against 80% in context) and costs 36-38 GSM8K points at every dose. Writing a conclusion as behaviour instead, by distilling the model's own conclusion-conditioned judgments into a low-rank adapter, reaches the in-context ceiling (0.83 and 0.88 against 0.84 and 0.88 on 100 games) with GSM8K unchanged, and the conclusion can come from an inquiry loop that found it by asking information-gain questions.

  • 1 authors
·
Oct 9

FCN: Fusing Exponential and Linear Cross Network for Click-Through Rate Prediction

As an important modeling paradigm in click-through rate (CTR) prediction, the Deep & Cross Network (DCN) and its derivative models have gained widespread recognition primarily due to their success in a trade-off between computational cost and performance. This paradigm employs a cross network to explicitly model feature interactions with linear growth, while leveraging deep neural networks (DNN) to implicitly capture higher-order feature interactions. However, these models still face several key limitations: (1) The performance of existing explicit feature interaction methods lags behind that of implicit DNN, resulting in overall model performance being dominated by the DNN; (2) While these models claim to capture high-order feature interactions, they often overlook potential noise within these interactions; (3) The learning process for different interaction network branches lacks appropriate supervision signals; and (4) The high-order feature interactions captured by these models are often implicit and non-interpretable due to their reliance on DNN. To address the identified limitations, this paper proposes a novel model, called Fusing Cross Network (FCN), along with two sub-networks: Linear Cross Network (LCN) and Exponential Cross Network (ECN). FCN explicitly captures feature interactions with both linear and exponential growth, eliminating the need to rely on implicit DNN. Moreover, we introduce the Self-Mask operation to filter noise layer by layer and reduce the number of parameters in the cross network by half. To effectively train these two cross networks, we propose a simple yet effective loss function called Tri-BCE, which provides tailored supervision signals for each network. We evaluate the effectiveness, efficiency, and interpretability of FCN on six benchmark datasets. Furthermore, by integrating LCN and ECN, FCN achieves a new state-of-the-art performance.

  • 6 authors
·
Jul 18, 2024

Learning Rates as a Function of Batch Size: A Random Matrix Theory Approach to Neural Network Training

We study the effect of mini-batching on the loss landscape of deep neural networks using spiked, field-dependent random matrix theory. We demonstrate that the magnitude of the extremal values of the batch Hessian are larger than those of the empirical Hessian. We also derive similar results for the Generalised Gauss-Newton matrix approximation of the Hessian. As a consequence of our theorems we derive an analytical expressions for the maximal learning rates as a function of batch size, informing practical training regimens for both stochastic gradient descent (linear scaling) and adaptive algorithms, such as Adam (square root scaling), for smooth, non-convex deep neural networks. Whilst the linear scaling for stochastic gradient descent has been derived under more restrictive conditions, which we generalise, the square root scaling rule for adaptive optimisers is, to our knowledge, completely novel. %For stochastic second-order methods and adaptive methods, we derive that the minimal damping coefficient is proportional to the ratio of the learning rate to batch size. We validate our claims on the VGG/WideResNet architectures on the CIFAR-100 and ImageNet datasets. Based on our investigations of the sub-sampled Hessian we develop a stochastic Lanczos quadrature based on the fly learning rate and momentum learner, which avoids the need for expensive multiple evaluations for these key hyper-parameters and shows good preliminary results on the Pre-Residual Architecure for CIFAR-100.

  • 3 authors
·
Jun 16, 2020

Rate limits in quantum networks with lossy repeaters

The derivation of ultimate limits to communication over certain quantum repeater networks have provided extremely valuable benchmarks for assessing near-term quantum communication protocols. However, these bounds are usually derived in the limit of ideal devices and leave questions about the performance of practical implementations unanswered. To address this challenge, we quantify how the presence of loss in repeater stations affect the maximum attainable rates for quantum communication over linear repeater chains and more complex quantum networks. Extending the framework of node splitting, we model the loss introduced at the repeater stations and then prove the corresponding limits. In the linear chain scenario we show that, by increasing the number of repeater stations, the maximum rate cannot overcome a quantity which solely depends on the loss of a single station. We introduce a way of adapting the standard machinery for obtaining bounds to this realistic scenario. The difference is that whilst ultimate limits for any strategy can be derived given a fixed channel, when the repeaters introduce additional decoherence, then the effective overall channel is itself a function of the chosen repeater strategy (e.g., one-way versus two-way classical communication). Classes of repeater strategies can be analysed using additional modelling and the subsequent bounds can be interpreted as the optimal rate within that class.

  • 4 authors
·
Oct 19, 2021

Mitigating photon loss in linear optical quantum circuits

Photon loss rates set an effective upper limit on the size of computations that can be run on current linear optical quantum devices. We present a family of techniques designed to mitigate the effects of photon loss on both output probabilities and expectation values derived from noisy linear optical circuits composed of an input of n photons, an m-mode interferometer, and m single photon detectors. Central to these techniques is the construction recycled probabilities. Recycled probabilities are constructed from output statistics affected by loss, and are designed to amplify the signal of the ideal (lossless) probabilities. Classical postprocessing techniques then take recycled probabilities as input and output a set of loss-mitigated probabilities, or expectation values. Our postprocessing methods result in biased estimators of the lossless probabilities. Nevertheless, we provide both analytical and numerical evidence that these methods can be applied, up to large sample sizes, to produce output probabilities with lower combined bias and statistical errors than the statistical errors of the output probabilities obtained from postselection. Therefore, these methods can outperform postselection - currently the standard method of coping with photon loss when sampling from discrete variable linear optical quantum circuits. In contrast, we provide evidence that the popular zero-noise extrapolation technique cannot improve on the performance of postselection for any photon loss rate.

  • 2 authors
·
Mar 10

Variable frame rate-based data augmentation to handle speaking-style variability for automatic speaker verification

The effects of speaking-style variability on automatic speaker verification were investigated using the UCLA Speaker Variability database which comprises multiple speaking styles per speaker. An x-vector/PLDA (probabilistic linear discriminant analysis) system was trained with the SRE and Switchboard databases with standard augmentation techniques and evaluated with utterances from the UCLA database. The equal error rate (EER) was low when enrollment and test utterances were of the same style (e.g., 0.98% and 0.57% for read and conversational speech, respectively), but it increased substantially when styles were mismatched between enrollment and test utterances. For instance, when enrolled with conversation utterances, the EER increased to 3.03%, 2.96% and 22.12% when tested on read, narrative, and pet-directed speech, respectively. To reduce the effect of style mismatch, we propose an entropy-based variable frame rate technique to artificially generate style-normalized representations for PLDA adaptation. The proposed system significantly improved performance. In the aforementioned conditions, the EERs improved to 2.69% (conversation -- read), 2.27% (conversation -- narrative), and 18.75% (pet-directed -- read). Overall, the proposed technique performed comparably to multi-style PLDA adaptation without the need for training data in different speaking styles per speaker.

  • 6 authors
·
Aug 8, 2020

Successive Linear Approximation VBI for Joint Sparse Signal Recovery and Dynamic Grid Parameters Estimation

For many practical applications in wireless communications, we need to recover a structured sparse signal from a linear observation model with dynamic grid parameters in the sensing matrix. Conventional expectation maximization (EM)-based compressed sensing (CS) methods, such as turbo compressed sensing (Turbo-CS) and turbo variational Bayesian inference (Turbo-VBI), have double-loop iterations, where the inner loop (E-step) obtains a Bayesian estimation of sparse signals and the outer loop (M-step) obtains a point estimation of dynamic grid parameters. This leads to a slow convergence rate. Furthermore, each iteration of the E-step involves a complicated matrix inverse in general. To overcome these drawbacks, we first propose a successive linear approximation VBI (SLA-VBI) algorithm that can provide Bayesian estimation of both sparse signals and dynamic grid parameters. Besides, we simplify the matrix inverse operation based on the majorization-minimization (MM) algorithmic framework. In addition, we extend our proposed algorithm from an independent sparse prior to more complicated structured sparse priors, which can exploit structured sparsity in specific applications to further enhance the performance. Finally, we apply our proposed algorithm to solve two practical application problems in wireless communications and verify that the proposed algorithm can achieve faster convergence, lower complexity, and better performance compared to the state-of-the-art EM-based methods.

  • 4 authors
·
Jul 18, 2023

Tunable Tool-Call Rates in LLM Agents via Representation Steering

Deciding whether to call a tool is a core competence of an LLM agent, and a costly one to get wrong: needless calls add latency, accrue cost, and may trigger irreversible side effects, while missing calls leave the model confidently wrong on questions it could only answer through tool-calls. Models manage this balance poorly, both over-using and under-using tools. Existing methods such as post-training and prompt engineering are expensive and difficult to modify at inference time. We show that whether an instruction-tuned model calls a tool can be controlled by a single linear direction in its residual stream, extracted without any training from the model's own tool-use preference signal and turned into an inference-time intervention with no prompt change. Adding the direction with strength α moves the call rate monotonically from near 0% to over 90% while keeping calls well-formed. The steering works in both directions: dialing it down suppresses calls, and dialing it up induces new calls that land precisely on the questions the model cannot answer from its own knowledge. We also show that the direction generalizes to unseen tools with strength comparable to each tool's own direction and without favoring any specific tool choice. With live tool execution, a single sweep of the steering traces a cost/accuracy Pareto frontier and nearly doubles open-domain QA accuracy (0.29 ! rightarrow ! 0.56); the same recipe transfers across a diverse range of models spanning dense, MoE, and multimodal architectures, without any training. Our code is publicly available at https://github.com/YuqiChen4188/Steering-Tool-Use-Propensity.

  • 5 authors
·
Aug 24

Linear Attention Architectures: Mechanisms, Trade-offs, and Cross-Layer Routing

Self-attention lets each token retrieve information from the full context, but its quadratic cost in sequence length limits training and inference at long context. This paper presents a comparative study of softmax attention and four recent recurrent linear-attention architectures: DeltaNet, Gated DeltaNet, Kimi Delta Attention, and Gated DeltaNet-2. We express these mechanisms in a common recurrent-memory notation, making explicit how they differ in expressivity, memory decay, erase and write control, training throughput, and implementation complexity. Our experiments center on 350M-parameter models trained for 15B tokens, and include optimizer and learning-rate comparisons, hybrid-versus-pure stack comparisons, sequence-length runtime measurements, larger DeltaNet runs at 1.3B and 3B parameters, and a small set of downstream evaluations. The reported speed results measure training throughput and iteration time; we do not provide an empirical inference-speed benchmark. Within the reported 350M-parameter, 15B-token sweep, Kimi Delta Attention with Muon reaches the lowest final validation loss, a pure Gated DeltaNet stack trained with AdamW has the highest normalized training throughput, hybrid stacks generally improve loss at a throughput cost, and Muon consistently lowers final validation loss relative to AdamW in the matched architecture settings we evaluate. We introduce and evaluate lightweight cross-layer routing mechanisms for DeltaNet-style memories. The most natural DeltaNet-inspired formulation, forwarding a lower layer's delta-rule write error into the next layer's value target, does not improve over matched baselines. Routing into the aligned hidden stream and forwarding the write value instead yields a modest improvement in the matched runs we report: Cross-Layer Value Routing (CLVR) lowers final validation loss for both DeltaNet and Gated DeltaNet.

ethz ETH Zurich
·
Jul 7 2

StreamMind: Unlocking Full Frame Rate Streaming Video Dialogue through Event-Gated Cognition

With the rise of real-world human-AI interaction applications, such as AI assistants, the need for Streaming Video Dialogue is critical. To address this need, we introduce StreamMind, a video LLM framework that achieves ultra-FPS streaming video processing (100 fps on a single A100) and enables proactive, always-on responses in real time, without explicit user intervention. To solve the key challenge of the contradiction between linear video streaming speed and quadratic transformer computation cost, we propose a novel perception-cognition interleaving paradigm named ''event-gated LLM invocation'', in contrast to the existing per-time-step LLM invocation. By introducing a Cognition Gate network between the video encoder and the LLM, LLM is only invoked when relevant events occur. To realize the event feature extraction with constant cost, we propose Event-Preserving Feature Extractor (EPFE) based on state-space method, generating a single perception token for spatiotemporal features. These techniques enable the video LLM with full-FPS perception and real-time cognition response. Experiments on Ego4D and SoccerNet streaming tasks, as well as standard offline benchmarks, demonstrate state-of-the-art performance in both model capability and real-time efficiency, paving the way for ultra-high-FPS applications, such as Game AI and interactive media. The code and data is available at https://aka.ms/StreamMind.

  • 7 authors
·
Sep 6, 2025

HyperQuant: A Rate-Distortion-Optimal Quantization Pipeline for Large Language and Diffusion Models

We present HyperQuant (Hadamard, optimallY Packing, Entropy Rice-coding), a unified post-training quantization pipeline for the weights and the KV cache of large language and diffusion transformers. Across a suite of self-contained experiments (Table 1), HyperQuant outperforms the recent HIGGS scheme at every operating point from 3 to 5 bits per scalar (bps) on weights, and beats both TurboQuant and OCTOPUS on KV quantization down to 1.7 bps. Beyond the LLM setting, HyperQuant quantizes the 19B-parameter LTX-2 DiT video model with no observable per-frame artifacts. End-to-end on an H100 at 4 bps, HyperQuant compresses the linear weights ~3.9x and the KV cache ~3.79x at near-lossless quality. HyperQuant combines four known ideas into a single construction: (i) a per-tile Randomized Hadamard Transform that makes the per-coordinate distribution of weights and activations approximately Gaussian; (ii) quantization to a low-dimensional optimal lattice (E8, D4, A2, or Z); (iii) lossless bit-stripping and near-entropy-optimal variable-length Rice coding of the lattice indices; and (iv) bias-correction methods for the KV cache that keep the reconstruction unbiased under inner products, preserving attention semantics. We further integrate the pipeline with 8-bit and 4-bit Tensor-Core MMA paths (fp8-e4m3, int8, nvfp4, mxfp4), and find that int8 beats fp8 on the post-RHT lattice output. Project page: https://moonmath.ai/hyperquant/

  • 3 authors
·
Jun 21

Linear Bandits beyond Inner Product Spaces, the case of Bandit Optimal Transport

Linear bandits have long been a central topic in online learning, with applications ranging from recommendation systems to adaptive clinical trials. Their general learnability has been established when the objective is to minimise the inner product between a cost parameter and the decision variable. While this is highly general, this reliance on an inner product structure belies the name of linear bandits, and fails to account for problems such as Optimal Transport. Using the Kantorovich formulation of Optimal Transport as an example, we show that an inner product structure is not necessary to achieve efficient learning in linear bandits. We propose a refinement of the classical OFUL algorithm that operates by embedding the action set into a Hilbertian subspace, where confidence sets can be built via least-squares estimation. Actions are then constrained to this subspace by penalising optimism. The analysis is completed by leveraging convergence results from penalised (entropic) transport to the Kantorovich problem. Up to this approximation term, the resulting algorithm achieves the same trajectorial regret upper bounds as the OFUL algorithm, which we turn into worst-case regret using functional regression techniques. Its regret interpolates between mathcal O(T) and {mathcal O}(T), depending on the regularity of the cost function, and recovers the parametric rate mathcal O(dT) in finite-dimensional settings.

  • 1 authors
·
Feb 16

Faster Rates of Convergence to Stationary Points in Differentially Private Optimization

We study the problem of approximating stationary points of Lipschitz and smooth functions under (varepsilon,delta)-differential privacy (DP) in both the finite-sum and stochastic settings. A point w is called an alpha-stationary point of a function F:R^drightarrowR if |nabla F(w)|leq alpha. We provide a new efficient algorithm that finds an Obig(big[sqrt{d}{nvarepsilon}big]^{2/3}big)-stationary point in the finite-sum setting, where n is the number of samples. This improves on the previous best rate of Obig(big[sqrt{d}{nvarepsilon}big]^{1/2}big). We also give a new construction that improves over the existing rates in the stochastic optimization setting, where the goal is to find approximate stationary points of the population risk. Our construction finds a Obig(1{n^{1/3}} + big[sqrt{d}{nvarepsilon}big]^{1/2}big)-stationary point of the population risk in time linear in n. Furthermore, under the additional assumption of convexity, we completely characterize the sample complexity of finding stationary points of the population risk (up to polylog factors) and show that the optimal rate on population stationarity is tilde Thetabig(1{n}+sqrt{d}{nvarepsilon}big). Finally, we show that our methods can be used to provide dimension-independent rates of Obig(1{n}+minbig(big[sqrt{rank}{nvarepsilon}big]^{2/3},1{(nvarepsilon)^{2/5}}big)big) on population stationarity for Generalized Linear Models (GLM), where rank is the rank of the design matrix, which improves upon the previous best known rate.

  • 6 authors
·
Jun 1, 2022

LiPCoT: Linear Predictive Coding based Tokenizer for Self-supervised Learning of Time Series Data via Language Models

Language models have achieved remarkable success in various natural language processing tasks. However, their application to time series data, a crucial component in many domains, remains limited. This paper proposes LiPCoT (Linear Predictive Coding based Tokenizer for time series), a novel tokenizer that encodes time series data into a sequence of tokens, enabling self-supervised learning of time series using existing Language model architectures such as BERT. Unlike traditional time series tokenizers that rely heavily on CNN encoder for time series feature generation, LiPCoT employs stochastic modeling through linear predictive coding to create a latent space for time series providing a compact yet rich representation of the inherent stochastic nature of the data. Furthermore, LiPCoT is computationally efficient and can effectively handle time series data with varying sampling rates and lengths, overcoming common limitations of existing time series tokenizers. In this proof-of-concept work, we present the effectiveness of LiPCoT in classifying Parkinson's disease (PD) using an EEG dataset from 46 participants. In particular, we utilize LiPCoT to encode EEG data into a small vocabulary of tokens and then use BERT for self-supervised learning and the downstream task of PD classification. We benchmark our approach against several state-of-the-art CNN-based deep learning architectures for PD detection. Our results reveal that BERT models utilizing self-supervised learning outperformed the best-performing existing method by 7.1% in precision, 2.3% in recall, 5.5% in accuracy, 4% in AUC, and 5% in F1-score highlighting the potential for self-supervised learning even on small datasets. Our work will inform future foundational models for time series, particularly for self-supervised learning.

  • 1 authors
·
Aug 14, 2024

LinGen: Towards High-Resolution Minute-Length Text-to-Video Generation with Linear Computational Complexity

Text-to-video generation enhances content creation but is highly computationally intensive: The computational cost of Diffusion Transformers (DiTs) scales quadratically in the number of pixels. This makes minute-length video generation extremely expensive, limiting most existing models to generating videos of only 10-20 seconds length. We propose a Linear-complexity text-to-video Generation (LinGen) framework whose cost scales linearly in the number of pixels. For the first time, LinGen enables high-resolution minute-length video generation on a single GPU without compromising quality. It replaces the computationally-dominant and quadratic-complexity block, self-attention, with a linear-complexity block called MATE, which consists of an MA-branch and a TE-branch. The MA-branch targets short-to-long-range correlations, combining a bidirectional Mamba2 block with our token rearrangement method, Rotary Major Scan, and our review tokens developed for long video generation. The TE-branch is a novel TEmporal Swin Attention block that focuses on temporal correlations between adjacent tokens and medium-range tokens. The MATE block addresses the adjacency preservation issue of Mamba and improves the consistency of generated videos significantly. Experimental results show that LinGen outperforms DiT (with a 75.6% win rate) in video quality with up to 15times (11.5times) FLOPs (latency) reduction. Furthermore, both automatic metrics and human evaluation demonstrate our LinGen-4B yields comparable video quality to state-of-the-art models (with a 50.5%, 52.1%, 49.1% win rate with respect to Gen-3, LumaLabs, and Kling, respectively). This paves the way to hour-length movie generation and real-time interactive video generation. We provide 68s video generation results and more examples in our project website: https://lineargen.github.io/.

  • 13 authors
·
Dec 12, 2024 4

Noise-Adaptive Layerwise Learning Rates: Accelerating Geometry-Aware Optimization for Deep Neural Network Training

Geometry-aware optimization algorithms, such as Muon, have achieved remarkable success in training deep neural networks (DNNs). These methods leverage the underlying geometry of DNNs by selecting appropriate norms for different layers and updating parameters via norm-constrained linear minimization oracles (LMOs). However, even within a group of layers associated with the same norm, the local curvature can be heterogeneous across layers and vary dynamically over the course of training. For example, recent work shows that sharpness varies substantially across transformer layers and throughout training, yet standard geometry-aware optimizers impose fixed learning rates to layers within the same group, which may be inefficient for DNN training. In this paper, we introduce a noise-adaptive layerwise learning rate scheme on top of geometry-aware optimization algorithms and substantially accelerate DNN training compared to methods that use fixed learning rates within each group. Our method estimates gradient variance in the dual norm induced by the chosen LMO on the fly, and uses it to assign time-varying noise-adaptive layerwise learning rates within each group. We provide a theoretical analysis showing that our algorithm achieves a sharp convergence rate. Empirical results on transformer architectures such as LLaMA and GPT demonstrate that our approach achieves faster convergence than state-of-the-art optimizers.

  • 5 authors
·
Oct 15, 2025

The Geometry of Refusal: Linear Instability in Safety-Aligned LLMs

Modern Large Language Models (LLMs) rely on extensive safety alignment, yet the mechanistic basis of refusal remains opaque. In this work, we investigate whether safety compliance is a deep semantic decision or a manipulable linear feature. We introduce Contrastive Logit Steering (CLS), a zero-optimization framework that isolates the "refusal direction" by contrasting hidden states derived from safe and unrestricted system prompts. Unlike representation engineering methods that intervene on internal activations, CLS operates directly on the output distribution, serving as a diagnostic probe for alignment fragility. When coupled with prefix injection to bypass initial refusal reflexes, this method induces a phase transition where guardrails collapse. Our experiments on 7 model families reveal that safety implementation is architecturally deterministic. While models like Llama-3.1 exhibit a "Late Decision" topology that is easily bypassed by CLS (reaching 95% ASR in approximately one second), others like Qwen-2.5 demonstrate "Early Divergence" by integrating safety mid-computation. Direct comparison with established activation-level steering methods shows that CLS achieves substantially higher attack success rates on Llama 2 (73% vs. 22.6%) and Qwen 7B (91% vs. 79.2%), demonstrating that logit-level intervention exposes alignment vulnerabilities that hidden-state methods underestimate. Beyond attacks, we show that this linearity enables bidirectional control: inverting the steering vector "hardens" models against jailbreaks without retraining. Our findings suggest that current alignment techniques create a steerable "safety axis" that serves as both a critical vulnerability and a precise primitive for defense.

  • 2 authors
·
Jun 20

When, Why and How Much? Adaptive Learning Rate Scheduling by Refinement

Learning rate schedules used in practice bear little resemblance to those recommended by theory. We close much of this theory/practice gap, and as a consequence are able to derive new problem-adaptive learning rate schedules. Our key technical contribution is a refined analysis of learning rate schedules for a wide class of optimization algorithms (including SGD). In contrast to most prior works that study the convergence of the average iterate, we study the last iterate, which is what most people use in practice. When considering only worst-case analysis, our theory predicts that the best choice is the linear decay schedule: a popular choice in practice that sets the stepsize proportionally to 1 - t/T, where t is the current iteration and T is the total number of steps. To go beyond this worst-case analysis, we use the observed gradient norms to derive schedules refined for any particular task. These refined schedules exhibit learning rate warm-up and rapid learning rate annealing near the end of training. Ours is the first systematic approach to automatically yield both of these properties. We perform the most comprehensive evaluation of learning rate schedules to date, evaluating across 10 diverse deep learning problems, a series of LLMs, and a suite of logistic regression problems. We validate that overall, the linear-decay schedule matches or outperforms all commonly used default schedules including cosine annealing, and that our schedule refinement method gives further improvements.

  • 4 authors
·
Oct 11, 2023

ScatterFormer: Efficient Voxel Transformer with Scattered Linear Attention

Window-based transformers excel in large-scale point cloud understanding by capturing context-aware representations with affordable attention computation in a more localized manner. However, the sparse nature of point clouds leads to a significant variance in the number of voxels per window. Existing methods group the voxels in each window into fixed-length sequences through extensive sorting and padding operations, resulting in a non-negligible computational and memory overhead. In this paper, we introduce ScatterFormer, which to the best of our knowledge, is the first to directly apply attention to voxels across different windows as a single sequence. The key of ScatterFormer is a Scattered Linear Attention (SLA) module, which leverages the pre-computation of key-value pairs in linear attention to enable parallel computation on the variable-length voxel sequences divided by windows. Leveraging the hierarchical structure of GPUs and shared memory, we propose a chunk-wise algorithm that reduces the SLA module's latency to less than 1 millisecond on moderate GPUs. Furthermore, we develop a cross-window interaction module that improves the locality and connectivity of voxel features across different windows, eliminating the need for extensive window shifting. Our proposed ScatterFormer demonstrates 73.8 mAP (L2) on the Waymo Open Dataset and 72.4 NDS on the NuScenes dataset, running at an outstanding detection rate of 23 FPS.The code is available at https://github.com/skyhehe123/ScatterFormer{https://github.com/skyhehe123/ScatterFormer}.

  • 4 authors
·
Dec 31, 2023

SemField: A Simple, Linear, Continuous, yet Robust Semantic Watermark

The rapid proliferation of Large Language Models (LLMs) necessitates reliable watermarking techniques to identify AI-generated text and ensure appropriate attribution. While token-based watermarks are vulnerable to paraphrasing, a central challenge for semantic watermarking is to turn sentence meanings into a stable, well-calibrated document-level signal. To this end, we introduce SemField, a simple, training-free semantic watermark that embeds a continuous, linear signal directly into the sentence embedding space. Using a shared secret key to define a specific Gaussian direction, SemField iteratively evaluates candidate sentences and selects those that maximize the alignment of the cumulative document aggregate with this targeted direction. We also propose SemField-PL, a polarity-locked variant that first determines the optimal orientation from the initial sentence and continuously reinforces it throughout the generation process. The document-level aggregated formulation guarantees exact invariance to sentence reordering and provides theoretical bounds against structural tampering, such as sentence insertion and deletion. Lastly, with extensive evaluations across three models, we demonstrate that both variants outperform 12 recent baselines. Across clean detection and four paraphrasing attacks, both variants achieve a mean True Positive Rate (TPR) of 88.2% to 90.4% at a 1% False Positive Rate (FPR), all while maintaining comparable perplexity and naturalness as human-generated content. We open-source our implementation at https://github.com/declare-lab/SemField

  • 3 authors
·
Oct 7

ForwardDLO: Model-Based Bimanual Shape Matching of Unconstrained Deformable Linear Objects

Ropes, cables, and other deformable linear objects appear in tasks from untangling to cable routing and suturing, yet controlling their shape remains a challenge in robot manipulation. We study model-based shape control in a general setting: the object lies unfixated on a support surface and two arms may grasp and move it anywhere along its length. Because each arm chooses a grasp point, direction, and magnitude, the joint action space is combinatorially large, and the dynamics model's per-prediction cost bounds how much of it a planner can search. We present ForwardDLO, a recurrent latent dynamics model for this unfixated bimanual setting that predicts per-segment displacements grounded in the observed rope state at every step. Our model reaches accuracy comparable to more expensive baselines while containing no explicit segment-to-segment operations, which makes batched evaluation of candidate actions cheap. On open-loop prediction of real rope motion it reaches the lowest error of the learned models we evaluate, 13% below the strongest baseline. Within a fixed time budget it scores 8 to 22 times more candidate actions than models of comparable accuracy while matching them in real-world shape matching; and on a simulated routing task at a 30Hz control rate, this throughput converts into 98% task success versus at most 30% for the baselines at their own budgets. We release the model, code, and a dataset of 2.42 million simulated and 14,107 real rope transitions at https://anonymous.4open.science/r/ForwardDLO/

  • 6 authors
·
Sep 16

ReaDy: Recurrent States as Dynamic Context for Speculative Drafting in Hybrid Linear Attention Large Language Models

Speculative decoding accelerates autoregressive generation by drafting multiple tokens per step, yet feature-based drafters rely on target hidden features whose contextual emphasis may not align with the needs of subsequent draft positions. Hybrid linear attention (HLA) models maintain compact recurrent states that accumulate historical associations, offering an efficient source of complementary context for speculative drafting. We introduce ReaDy, the first speculative decoding method, to the best of our knowledge, to leverage HLA recurrent states for position-specific context retrieval during drafting. ReaDy equips each draft position with a learned query to retrieve supplementary context directly from the target's committed recurrent states. A lightweight state reader integrates this context into draft representations through residual updates, while low-rank state reads and fused operators keep additional computation and I/O overhead low. Building on DSpark's parallel backbone and sequential prediction head, ReaDy employs a lightweight two-stage adaptation strategy, with reader capacity, state sources, and residual placement examined through ablation studies. Across seven benchmarks spanning mathematics, code generation, and dialogue, ReaDy achieves an average 3.16times decoding speedup over autoregressive decoding with Qwen3.8-27B on a single NVIDIA B200 GPU. It outperforms DSpark on every benchmark, improving throughput by 7.97% and acceptance length by 8.50% on average. Our code is available at https://github.com/StartLuxLabs/ReaDy.

  • 6 authors
·
Oct 13 2

Provably Data-driven Lagrangian Relaxation for Mixed Integer Linear Programming

Lagrangian Relaxation (LR) is a powerful technique for solving large-scale Mixed Integer Linear Programming (MILP), particularly those with decomposable structures, such as vehicle routing or unit commitment problems. By relaxing the coupling constraints, LR enables parallel subproblem solving and often yields tighter dual bounds than standard linear programming relaxations, which is crucial for efficient branch-and-bound pruning. While recent empirical work has shown promising results using machine learning to predict these multipliers, a theoretical understanding of such methods remains an open question. In this work, we bridge this gap by analyzing the problem of learning LR through the lens of Data-driven Algorithm Design, i.e., a statistical learning problem over a distribution of problem instances. Our contributions are as follows: first, we derive a generalization bound of O(s^{1.5}/N) for the learned multipliers, where s is the number of coupling constraints and N is the sample size. Second, we provide a minimax lower-bound of Ω(s/N), proving that a linear dependency is unavoidable. Third, we constructively close this theoretical gap by proving that Stochastic Gradient Ascent (SGA) with averaging achieves the minimax optimal rate Θ(s/N). Finally, we extend our framework to the learning-to-warm-start setting, proving that it achieves a fast, minimax-optimal rate of Θ(s/N) and establishing a theoretical advantage over direct multiplier prediction.

  • 3 authors
·
May 24

Counterfactual Generation via Flow Matching: Coupling-Sensitive End-to-End Rates

Counterfactual generation seeks to sample outcomes under a hypothetical intervention or decision using observational data collected under the factual assignment mechanism. We develop a flow-matching approach that combines a sample-split, doubly robust training objective with a learned coupling between observed source outcomes and target outcomes drawn from a fitted conditional outcome model. To enable finite-step generation, we leverage a score-corrected stochastic sampler based on a Gaussian-smoothed interpolation. Our main theoretical contribution is a coupling-sensitive KL bound for constant-step Euler discretization: the error is controlled by moments of the source--target displacement under the chosen coupling, rather than by global uniform regularity of the velocity field, and has near-linear dependence on the ambient dimension. We also establish finite-sample non-parametric guarantees for the learned velocity and score fields when both the conditional outcome model and the source-target coupling are estimated from data. These bounds separate approximation, coupling-replacement, nuisance-estimation, generalization, and Monte Carlo errors and, combined with the sampler analysis, yield an end-to-end guarantee for counterfactual generation. Experiments on synthetic and semi-synthetic image benchmarks support the coupling-dependent theory and show that, at finite discretization budgets, the stochastic sampler can outperform the corresponding deterministic ODE sampler.

  • 3 authors
·
Sep 30

Polynomial Acceleration of Alternating Projections: Chebyshev Acceleration, Convergence Rates, and Retractions

Alternating projections (AP) near a clean intersection of smooth manifolds can converge slowly when the Friedrichs angle is small. We develop the Fixed-Point Manifold Acceleration (FPMA) framework for {local convergence and polynomial acceleration of} smooth maps that fix a manifold pointwise. {Under suitable regularity and uniform normal spectral stability, FPMA establishes local R-linear convergence and a smooth limiting map inducing a local retraction. At fixed points, consistent polynomial acceleration with p(1)=1 preserves the selected limit's first-order response to normal initial perturbations whenever the transformed normal blocks are uniformly spectrally stable. Under sufficient smoothness, we give a curvature criterion for second-order induced retractions and show that stable consistent polynomial acceleration preserves both the quadratic retraction expansion and this criterion. {As a special case, we establish new local R-linear convergence guarantees for fixed-degree Chebyshev-accelerated exact AP and second-order induced retractions. For uniform Friedrichs angle θ_Fin(0,π/2), acceleration strictly improves the local convergence rate per AP evaluation. The large-degree limiting spectral factor at fixed θ_F predicts O(θ_F^{-1}) evaluations for fixed relative error reduction as θ_Fdownarrow0, versus O(θ_F^{-2}) for ordinary AP.}} {The framework also covers} inexact, relaxed, and generalized AP {under their respective regularity and stability conditions.}

  • 2 authors
·
Oct 4

Transformers Learn Higher-Order Optimization Methods for In-Context Learning: A Study with Linear Models

Transformers are remarkably good at in-context learning (ICL) -- learning from demonstrations without parameter updates -- but how they perform ICL remains a mystery. Recent work suggests that Transformers may learn in-context by internally running Gradient Descent, a first-order optimization method. In this paper, we instead demonstrate that Transformers learn to implement higher-order optimization methods to perform ICL. Focusing on in-context linear regression, we show that Transformers learn to implement an algorithm very similar to Iterative Newton's Method, a higher-order optimization method, rather than Gradient Descent. Empirically, we show that predictions from successive Transformer layers closely match different iterations of Newton's Method linearly, with each middle layer roughly computing 3 iterations. In contrast, exponentially more Gradient Descent steps are needed to match an additional Transformers layer; this suggests that Transformers have an comparable rate of convergence with high-order methods such as Iterative Newton, which are exponentially faster than Gradient Descent. We also show that Transformers can learn in-context on ill-conditioned data, a setting where Gradient Descent struggles but Iterative Newton succeeds. Finally, we show theoretical results which support our empirical findings and have a close correspondence with them: we prove that Transformers can implement k iterations of Newton's method with O(k) layers.

  • 4 authors
·
Oct 25, 2023

When Normalization Selects the Sign: Auditing Robustness Ablations in Quantum Attention

Removing an input-scaling module changes both a classifier and the perturbations reaching its encoder. A robustness difference can therefore reflect the comparison rule as well as the module. We demonstrate this problem in a four-qubit quantum-attention detector on generated power-grid trajectories. A learned scaling module appears beneficial at a fixed physical attack budget, but matching an upper bound on perturbations at the encoder reverses the ordering. Neither comparison alone establishes a robustness benefit caused by the module. The initial test also perturbs clean examples into attacked examples while retaining their original labels; tests restricted to already attacked examples do not establish a benefit. Replacing a trained model's input scales disrupts detection. Retraining its linear classification layer restores the detection rate, but changes individual predictions, leaving the comparison descriptive rather than causal. Two further design checks explain why the input quantum Fisher information regularizer cannot train this model's query parameters, and why removing confidence bounds does not establish a larger certified radius. The evidence is limited to ten seeds, exact simulation, synthetic data, and a restricted set of attacks; classical baselines achieve better clean prediction. The practical lesson is to specify which perturbation budget is fixed, check that attacks preserve labels and interventions preserve predictions, and distinguish exploratory controls from confirmatory evidence.

  • 4 authors
·
Oct 1

Aircrew rostering workload patterns and associated fatigue and sleepiness scores in short/medium haul flights under RBAC 117 rules in Brazil

The relationships between workload and fatigue or sleepiness are investigated through the analysis of rosters and responses to questionnaires from Brazilian aircrews, taken from Fadig\^ometro database. The approach includes temporal markers - coinciding with Samn-Perelli (SP) and Karolinska Sleepiness Scale (KSS) responses - where SAFTE-FAST model outcomes are calculated. The model results follow the increase of fatigue and sleepiness perceptions during the dawn (0h00 to 05h59), but underestimate the self-rated scores during the evening (18h00 to 23h59). On the other hand, the KSS scores fit the relative risk of pilot errors, representing a reasonable proxy for risk assessment. Linear relationships obtained between workload metrics, computed within 168-hours prior to the responses, and self-rated SP and KSS scores provide a consistent method to estimate accumulated fatigue and sleepiness. Considering 7149 rosters of 2023, the duty time (DT), the number of flight sectors (N_{CREW}) and the sum of flight sectors with sit periods longer than one hour (N_{CREW}+N_{SIT}) are associated with 70.1%/60.6% of the highest predicted scores of SP/KSS. Applying the mitigations DTleq44h, N_{CREW}leq15 and N_{CREW}+N_{SIT}leq19 for every 168-hour interval yields a significant decrease in the higher values of SP/KSS with minimal impact on aircrew productivity.

  • 8 authors
·
Aug 5, 2024

Unsupervised Manifold Linearizing and Clustering

We consider the problem of simultaneously clustering and learning a linear representation of data lying close to a union of low-dimensional manifolds, a fundamental task in machine learning and computer vision. When the manifolds are assumed to be linear subspaces, this reduces to the classical problem of subspace clustering, which has been studied extensively over the past two decades. Unfortunately, many real-world datasets such as natural images can not be well approximated by linear subspaces. On the other hand, numerous works have attempted to learn an appropriate transformation of the data, such that data is mapped from a union of general non-linear manifolds to a union of linear subspaces (with points from the same manifold being mapped to the same subspace). However, many existing works have limitations such as assuming knowledge of the membership of samples to clusters, requiring high sampling density, or being shown theoretically to learn trivial representations. In this paper, we propose to optimize the Maximal Coding Rate Reduction metric with respect to both the data representation and a novel doubly stochastic cluster membership, inspired by state-of-the-art subspace clustering results. We give a parameterization of such a representation and membership, allowing efficient mini-batching and one-shot initialization. Experiments on CIFAR-10, -20, -100, and TinyImageNet-200 datasets show that the proposed method is much more accurate and scalable than state-of-the-art deep clustering methods, and further learns a latent linear representation of the data.

  • 6 authors
·
Jan 4, 2023

Longitudinal causal inference under informative missingness using the self-censoring model

Longitudinal observational data are often subject to informative missingness. For example, in healthcare research using electronic health records, covariates and outcomes are measured only when patients interact with the healthcare system. Whether these data are observed usually depends on the unobserved variable values themselves, introducing a common form of data missing not at random. We develop identification and estimation methods for the effects of longitudinal modified treatment policies under a self-censoring model which explicitly models this dependence. We consider effects of treatments that can be modified only at measurement times (e.g., interactions with the heathcare system). We study two settings: one in which the observed history suffices for treatment confounding control, and another in which confounder control requires covariate values that were not measured at missed visits. In both settings, we combine longitudinal causal identification with shadow-variable conditional moment restrictions to obtain recursive identification formulas for the counterfactual outcome mean. We derive gradients of the pathwise derivatives and second-order remainder expansions, and use these results to construct estimators that accommodate machine learning for nuisance-function estimation. Under suitable product-rate conditions and cross-fitting, the estimators are asymptotically linear and permit root-n inference, including simultaneous inference across outcome times. We also describe conditional-moment learning and ensemble approaches for estimating the nuisance functions required by our approach, together with a pool-and-smooth strategy that borrows information across sparsely measured outcomes.

  • 1 authors
·
Oct 5

The Law of Knowledge Overshadowing: Towards Understanding, Predicting, and Preventing LLM Hallucination

Hallucination is a persistent challenge in large language models (LLMs), where even with rigorous quality control, models often generate distorted facts. This paradox, in which error generation continues despite high-quality training data, calls for a deeper understanding of the underlying LLM mechanisms. To address it, we propose a novel concept: knowledge overshadowing, where model's dominant knowledge can obscure less prominent knowledge during text generation, causing the model to fabricate inaccurate details. Building on this idea, we introduce a novel framework to quantify factual hallucinations by modeling knowledge overshadowing. Central to our approach is the log-linear law, which predicts that the rate of factual hallucination increases linearly with the logarithmic scale of (1) Knowledge Popularity, (2) Knowledge Length, and (3) Model Size. The law provides a means to preemptively quantify hallucinations, offering foresight into their occurrence even before model training or inference. Built on overshadowing effect, we propose a new decoding strategy CoDa, to mitigate hallucinations, which notably enhance model factuality on Overshadow (27.9%), MemoTrap (13.1%) and NQ-Swap (18.3%). Our findings not only deepen understandings of the underlying mechanisms behind hallucinations but also provide actionable insights for developing more predictable and controllable language models.

  • 11 authors
·
Feb 22, 2025

Let's Scale Step by Step: Compute-Efficient Hyperparameter Transfer for Large-Scale Mixture-of-Experts

Mixture-of-Experts (MoE) architectures significantly expand model capacity without a proportional increase in computational cost. However, optimizing their hyperparameters---particularly the learning rate---at extreme scales of both model size and token budget via sweeping remains computationally prohibitive. In this paper, we propose a compute-efficient, two-step hyperparameter transfer framework that estimates optimal learning rates for training large MoE models by transferring them across scaling model widths, and subsequently extrapolating to trillion-token horizons. First, we formulate a Maximal Update Parameterization (μP) adaptation for MoE architectures utilizing Multi-head Latent Attention (MLA) and the Muon optimizer, demonstrating that optimal learning rates transfer consistently across width-scaled models. Second, we extend this transferability along the token dimension by establishing a predictive scaling law. By applying linear regression to the optimal values derived from small proxy models on limited budgets, we successfully extrapolate the ideal learning rate to massive training horizons (e.g., 10 trillion tokens) with high fidelity (R^2=0.95). Consequently, this indicates that proxy training on small models is sufficient to determine the optimal learning rate for the extensive training of large-scale MoEs. We apply the proposed methodology to pretrain our foundation model (155B total, 17B active parameters) from scratch, and the stable training and evaluation results validate that optimal configurations for full-scale target models can be accurately predicted with minimal ablation costs.

kakaocorp Kakao Corp.
·
Aug 20 3

Tracking fast and slow changes in synaptic weights from simultaneously observed pre- and postsynaptic spiking

Synapses change on multiple timescales, ranging from milliseconds to minutes, due to a combination of both short- and long-term plasticity. Here we develop an extension of the common Generalized Linear Model to infer both short- and long-term changes in the coupling between a pre- and post-synaptic neuron based on observed spiking activity. We model short-term synaptic plasticity using additive effects that depend on the presynaptic spike timing, and we model long-term changes in both synaptic weight and baseline firing rate using point process adaptive smoothing. Using simulations, we first show that this model can accurately recover time-varying synaptic weights 1) for both depressing and facilitating synapses, 2) with a variety of long-term changes (including realistic changes, such as due to STDP), 3) with a range of pre- and post-synaptic firing rates, and 4) for both excitatory and inhibitory synapses. We then apply our model to two experimentally recorded putative synaptic connections. We find that simultaneously tracking fast changes in synaptic weights, slow changes in synaptic weights, and unexplained variations in baseline firing is essential. Omitting any one of these factors can lead to spurious inferences for the others. Altogether, this model provides a flexible framework for tracking short- and long-term variation in spike transmission.

  • 2 authors
·
Apr 8, 2021

Boosting Reservoir Computing with Brain-inspired Adaptive Dynamics

Reservoir computers (RCs) provide a computationally efficient alternative to deep learning while also offering a framework for incorporating brain-inspired computational principles. By using an internal neural network with random, fixed connections-the 'reservoir'-and training only the output weights, RCs simplify the training process but remain sensitive to the choice of hyperparameters that govern activation functions and network architecture. Moreover, typical RC implementations overlook a critical aspect of neuronal dynamics: the balance between excitatory and inhibitory (E-I) signals, which is essential for robust brain function. We show that RCs characteristically perform best in balanced or slightly over-inhibited regimes, outperforming excitation-dominated ones. To reduce the need for precise hyperparameter tuning, we introduce a self-adapting mechanism that locally adjusts E/I balance to achieve target neuronal firing rates, improving performance by up to 130% in tasks like memory capacity and time series prediction compared with globally tuned RCs. Incorporating brain-inspired heterogeneity in target neuronal firing rates further reduces the need for fine-tuning hyperparameters and enables RCs to excel across linear and non-linear tasks. These results support a shift from static optimization to dynamic adaptation in reservoir design, demonstrating how brain-inspired mechanisms improve RC performance and robustness while deepening our understanding of neural computation.

  • 3 authors
·
Apr 16, 2025

Envs-FORGE: Frontier-Optimized Reward-Grounded Environment Synthesis for Agent RL

Reinforcement learning (RL) for terminal agents needs executable training environments with reliable rewards and useful difficulty. Fixed recipes such as few-shot, Self-Instruct, and Evol-Instruct apply the same prompting policy to every seed, even when the current policy would benefit from a harder, easier, or simply different task. We present Envs-FORGE, a prompting policy that converts verifier rewards into per-seed environment-synthesis actions. Envs-FORGE estimates seed pass rates, scores six projection--direction actions around a target learning frontier, and solves a per-seed mixed-integer linear program (MILP) to choose the action that conditions generation. The selected action drives synchronized rewriting of the instruction, fixtures, oracle solution, tests, and Docker environment; only gold-verified bundles enter RL training. The indexed MILP form also supports optional soft skill coverage for portfolio planning. On Qwen 3.5 35B, Envs-FORGE improves Pass@1 over Base by 9.2 percentage points on tb-core (40.0% to 49.2%) and 6.4 points on tb-2.0 (23.0% to 29.4%), exceeding the strongest fixed-recipe baseline by 2.4 and 2.1 points. It reaches 77.1% on SWE-bench Verified versus 73.4% for Base, and improves tb-core by 6.8--9.2 points across the evaluated 4B--35B models. All synthesis methods export 100 verified environments and use 2.27M--2.88M synthesis tokens, placing the comparison at the same downstream training-set size and the same operational scale. The source code is available at https://github.com/DataArcTech/DataArc-SynData-Toolkit/.

  • 10 authors
·
Aug 13

EntroPack: Fast and Accurate Entropy-Coded Weight Compression at Arbitrary Bitrates

Weight compression helps large neural networks fit deployment memory budgets, but common fixed-width formats offer only coarse storage choices. Entropy coding supports finer rates, yet the achieved size depends on the quantized weight distribution and coding overhead. Exploiting this flexibility requires accurate rate selection and efficient weight reconstruction for inference. We present EntroPack, an entropy-coded weight compressor that supports arbitrary target bitrates without activation calibration or fine-tuning. It combines row-normalized E_8 lattice quantization with a conditional probability model of lattice coordinates. Sampled storage estimates select the quantization resolution without repeated full-stream encoding. The final coordinates are entropy-coded in independently decodable tiles, enabling fast, fused symbol decoding and numerical weight reconstruction on the GPU. EntroPack supports floating-point and integer weight containers, such as BF16, FP16, FP8, and INT8, with storage bitrate controlled independently of numerical precision. Online decoding adds latency that grows with weight count, making the method well suited to compute-intensive workloads such as diffusion denoising and Transformer prefill. Experiments demonstrate fast encoding and modest inference overhead in these settings. When compressing the linear-layer weights of the image generator Z-Image-Turbo, EntroPack achieves substantially lower weight and denoiser output errors than fixed-width formats at comparable storage rates, with modest denoising-step overhead. Targeting 4 bits per parameter, it achieves lower weight and denoiser output errors than NF4, including about 24% lower relative L_2 weight error, with less storage. Source code is available at https://github.com/modelscope/entropack.

  • 3 authors
·
Sep 27

Provably Robust DPO: Aligning Language Models with Noisy Feedback

Learning from preference-based feedback has recently gained traction as a promising approach to align language models with human interests. While these aligned generative models have demonstrated impressive capabilities across various tasks, their dependence on high-quality human preference data poses a bottleneck in practical applications. Specifically, noisy (incorrect and ambiguous) preference pairs in the dataset might restrict the language models from capturing human intent accurately. While practitioners have recently proposed heuristics to mitigate the effect of noisy preferences, a complete theoretical understanding of their workings remain elusive. In this work, we aim to bridge this gap by by introducing a general framework for policy optimization in the presence of random preference flips. We focus on the direct preference optimization (DPO) algorithm in particular since it assumes that preferences adhere to the Bradley-Terry-Luce (BTL) model, raising concerns about the impact of noisy data on the learned policy. We design a novel loss function, which de-bias the effect of noise on average, making a policy trained by minimizing that loss robust to the noise. Under log-linear parameterization of the policy class and assuming good feature coverage of the SFT policy, we prove that the sub-optimality gap of the proposed robust DPO (rDPO) policy compared to the optimal policy is of the order O(1{1-2epsilon}frac{d{n}}), where epsilon < 1/2 is flip rate of labels, d is policy parameter dimension and n is size of dataset. Our experiments on IMDb sentiment generation and Anthropic's helpful-harmless dataset show that rDPO is robust to noise in preference labels compared to vanilla DPO and other heuristics proposed by practitioners.

  • 3 authors
·
Mar 1, 2024

Accelerating Nash Learning from Human Feedback via Mirror Prox

Traditional Reinforcement Learning from Human Feedback (RLHF) often relies on reward models, frequently assuming preference structures like the Bradley-Terry model, which may not accurately capture the complexities of real human preferences (e.g., intransitivity). Nash Learning from Human Feedback (NLHF) offers a more direct alternative by framing the problem as finding a Nash equilibrium of a game defined by these preferences. In this work, we introduce Nash Mirror Prox (Nash-MP), an online NLHF algorithm that leverages the Mirror Prox optimization scheme to achieve fast and stable convergence to the Nash equilibrium. Our theoretical analysis establishes that Nash-MP exhibits last-iterate linear convergence towards the beta-regularized Nash equilibrium. Specifically, we prove that the KL-divergence to the optimal policy decreases at a rate of order (1+2beta)^{-N/2}, where N is a number of preference queries. We further demonstrate last-iterate linear convergence for the exploitability gap and uniformly for the span semi-norm of log-probabilities, with all these rates being independent of the size of the action space. Furthermore, we propose and analyze an approximate version of Nash-MP where proximal steps are estimated using stochastic policy gradients, making the algorithm closer to applications. Finally, we detail a practical implementation strategy for fine-tuning large language models and present experiments that demonstrate its competitive performance and compatibility with existing methods.

  • 8 authors
·
May 26, 2025 2

Decentralized Aerial Manipulation of a Cable-Suspended Load using Multi-Agent Reinforcement Learning

This paper presents the first decentralized method to enable real-world 6-DoF manipulation of a cable-suspended load using a team of Micro-Aerial Vehicles (MAVs). Our method leverages multi-agent reinforcement learning (MARL) to train an outer-loop control policy for each MAV. Unlike state-of-the-art controllers that utilize a centralized scheme, our policy does not require global states, inter-MAV communications, nor neighboring MAV information. Instead, agents communicate implicitly through load pose observations alone, which enables high scalability and flexibility. It also significantly reduces computing costs during inference time, enabling onboard deployment of the policy. In addition, we introduce a new action space design for the MAVs using linear acceleration and body rates. This choice, combined with a robust low-level controller, enables reliable sim-to-real transfer despite significant uncertainties caused by cable tension during dynamic 3D motion. We validate our method in various real-world experiments, including full-pose control under load model uncertainties, showing setpoint tracking performance comparable to the state-of-the-art centralized method. We also demonstrate cooperation amongst agents with heterogeneous control policies, and robustness to the complete in-flight loss of one MAV. Videos of experiments: https://autonomousrobots.nl/paper_websites/aerial-manipulation-marl

  • 5 authors
·
Aug 2, 2025 2

HorizonStream: Long-Horizon Attention for Streaming 3D Reconstruction

Online 3D reconstruction requires estimating camera pose and scene geometry under strict causal and bounded-memory constraints. Existing methods often suffer from drift, jitter, or collapse on long sequences. We trace these failures to a fundamental mismatch. Streaming geometry is inherently temporally heterogeneous, with evidence ranging from short-lived correspondences to persistent global scale. However, current architectures impose uniform and pathological influence patterns. For example, sliding windows enforce hard cutoffs, while ungated recurrence and causal attention cause cache saturation and spike-like attention sinks. To resolve this, we formalize geometric propagation as an evidence influence kernel and propose HorizonStream, a long-horizon Transformer that explicitly factorizes this kernel. For the long-range temporal factor, Geometric Linear Attention learns channel-wise decay rates to enable bounded, multi-timescale propagation of geometric evidence. For the short-range spatial factor, Geometric Local Attention with Spatiotemporal RoPE performs reliable 3D matching while suppressing attention sinks. Finally, Metric Readout Tokens recover stable scale and rigid pose directly from the persistent geometric state. Extensive experiments show that HorizonStream, trained on only 48-frame clips, generalizes stably to sequences exceeding 10,000\ frames with constant memory and linear time, achieving state-of-the-art streaming 3D reconstruction performance. Project Page: https://3dagentworld.github.io/horizonstream/

"You" Is Not Toxic: How LLM Labelers Rewrite the Web's Conversation Laws

What the Web community believes about toxic conversations, such as that toxicity rises in longer and deeper threads, was measured mostly with Google's Perspective API, which is shutting down; large language models (LLMs) will make the next measurements. We find that LLM labelers mistake second-person address for toxicity, and that this one bias manufactures laws that human labels do not show. On 1.25 million news comments with crowd labels, Claude Haiku flags 12% of the non-toxic comments that contain no "you" and 51% of those with four or more; a single crowd rater flags 6% and 10%. Deeper replies address someone more often, so under Haiku toxicity rises with reply depth (+0.93 percentage points per level), while under the crowd's labels it slightly declines (-0.12). Rewriting "you" in the third person removes two thirds of the false rise; flagging only as many comments as the crowd does not remove it, and showing Haiku the parent comment enlarges it. All seven LLMs we test over-flag "you", and at the crowd's flag rate, without the parent, any false rise of the open ones vanishes at a fixed number of second-person words; Haiku also over-flags "you" on Reddit, Gab and Wikipedia talk pages. Agreement with human labels does not reveal the bias: we prove that a fixed Cohen's kappa leaves a law nearly unconstrained. We therefore certify the law instead of the labeler. Threadsafe uses the labeler's scores to choose which comments human raters label and to predict the others, and corrects the predictions with the human labels; linear laws are estimated without bias whatever the labeler does. In simulated audits its intervals for the laws keep nominal coverage from 250 labels on, where uniform-sample methods such as PPI++ fall short, and at 1,000 to 8,000 labels are 0.75 times as wide as those of design-based supervised learning (DSL); a thousand human labels rule out Haiku's rising law.

  • 2 authors
·
Oct 16

A 5-Point Minimal Solver for Event Camera Relative Motion Estimation

Event-based cameras are ideal for line-based motion estimation, since they predominantly respond to edges in the scene. However, accurately determining the camera displacement based on events continues to be an open problem. This is because line feature extraction and dynamics estimation are tightly coupled when using event cameras, and no precise model is currently available for describing the complex structures generated by lines in the space-time volume of events. We solve this problem by deriving the correct non-linear parametrization of such manifolds, which we term eventails, and demonstrate its application to event-based linear motion estimation, with known rotation from an Inertial Measurement Unit. Using this parametrization, we introduce a novel minimal 5-point solver that jointly estimates line parameters and linear camera velocity projections, which can be fused into a single, averaged linear velocity when considering multiple lines. We demonstrate on both synthetic and real data that our solver generates more stable relative motion estimates than other methods while capturing more inliers than clustering based on spatio-temporal planes. In particular, our method consistently achieves a 100% success rate in estimating linear velocity where existing closed-form solvers only achieve between 23% and 70%. The proposed eventails contribute to a better understanding of spatio-temporal event-generated geometries and we thus believe it will become a core building block of future event-based motion estimation algorithms.

  • 6 authors
·
Sep 29, 2023

OstQuant: Refining Large Language Model Quantization with Orthogonal and Scaling Transformations for Better Distribution Fitting

Post-training quantization (PTQ) has emerged as a widely adopted technique for compressing and accelerating Large Language Models (LLMs). The major challenge in LLM quantization is that uneven and heavy-tailed data distributions can expand the quantization range, thereby reducing bit precision for most values. Recent methods attempt to eliminate outliers and balance inter-channel differences by employing linear transformations; however, they remain heuristic and are often overlook optimizing the data distribution across the entire quantization space.In this paper, we introduce Quantization Space Utilization Rate (QSUR), a novel metric that effectively assesses the quantizability of transformed data by measuring the space utilization of the data in the quantization space. We complement QSUR with mathematical derivations that examine the effects and limitations of various transformations, guiding our development of Orthogonal and Scaling Transformation-based Quantization (OSTQuant). OSQuant employs a learnable equivalent transformation, consisting of an orthogonal transformation and a scaling transformation, to optimize the distributions of weights and activations across the entire quantization space. Futhermore, we propose the KL-Top loss function, designed to mitigate noise during optimization while retaining richer semantic information within the limited calibration data imposed by PTQ. OSTQuant outperforms existing work on various LLMs and benchmarks. In the W4-only setting, it retains 99.5\% of the floating-point accuracy. In the more challenging W4A4KV4 configuration, OSTQuant reduces the performance gap by 32\% on the LLaMA-3-8B model compared to state-of-the-art methods. https://github.com/BrotherHappy/OSTQuant{https://github.com/BrotherHappy/OSTQuant}.

  • 9 authors
·
Jan 23, 2025

Scaling Laws for Speculative Decoding

The escalating demand for efficient decoding in large language models (LLMs) is particularly critical for reasoning-intensive architectures like OpenAI-o3 and DeepSeek-R1, which depend on extended chain-of-thought reasoning. This study investigates speculative decoding techniques through dense LLM architectures to establish foundational insights for accelerating reasoning tasks. While speculative decoding methods leveraging parallel draft-verification cycles have emerged as promising acceleration techniques, the scaling laws governing decoding efficiency remain under-explored compared to conventional backbone LLMs developed through Pretraining->SFT->RLHF training paradigms. In this work, we discover Log-linear Scaling Laws (Theorem 1.1, 1.2 and 1.3) governing draft model acceptance rate (or decoding speed) across three dimensions: pretraining token volume, draft model capacity, and decoding batch size. Building on these laws, we achieve Scylla, which coordinates multi-dimensional scaling for popular LLMs (Llama2/3, Qwen2.5). Empirical validation shows Scylla achieves 1.5-2.2 higher acceptance rate than EAGLE2 and 0.3 higher than EAGLE3 at temperature T = 0, with peak performance gains on summarization and QA tasks (Figure 2). Industrial inference engine deployments demonstrate 2X decoding throughput improvements over EAGLE2 (Table 5), validating the transformative potential of systematic scaling for efficient LLM inference. Code will be released later.

  • 11 authors
·
May 8, 2025

Breaking Entropy Bounds: Accelerating RL Training via MTP with Rejection Sampling

Reinforcement learning (RL) has become a key component in modern large language models, yet the rollout stage remains the key bottleneck in RL training pipelines. Although Multi-Token Prediction (MTP) offers a natural solution to accelerate rollouts through speculative decoding, many studies have observed that MTP acceptance rates degrade significantly during RL training, leading to limited speedup performance. To address this bottleneck, we present Bebop, a systematic study of MTP in LLM post-training, and offer practical recipes to integrate MTP into large-scale RL pipelines. First, we reveal that the MTP acceptance rate is fundamentally bounded by the fluctuation of model entropy, which demonstrates a clear negative linear relationship with the rise of entropy in the RL stage. Second, we show that probabilistic rejection sampling largely alleviates the disturbance introduced by entropy in RL compared to greedy draft sampling. We further identify that the conventional MTP training objectives (cross-entropy or KL) are suboptimal in such settings, and therefore we propose a novel end-to-end TV loss that directly optimizes multi-step rejection sampling acceptance rate, yielding ~10% acceptance rate improvements, achieving up to 95% acceptance rates and up to 25% extra inference throughput gains across mathematical reasoning, code generation, and agentic tasks. Third, we test various online MTP training strategies during RL and show that pre-RL MTP training with e2e TV loss and rejection sampling achieves a consistent acceptance rate and speedup throughout the entire RL, eliminating the need for costly online MTP updating. We provide extensive experiments and analysis that validate our findings. Experimental results show our method achieves up to 1.8x end-to-end acceleration in async RL training of Qwen3.5, Qwen3.6, and Qwen3.7 models.

Qwen Qwen
·
Jun 9 5

Bidirectional Learning for Offline Model-based Biological Sequence Design

Offline model-based optimization aims to maximize a black-box objective function with a static dataset of designs and their scores. In this paper, we focus on biological sequence design to maximize some sequence score. A recent approach employs bidirectional learning, combining a forward mapping for exploitation and a backward mapping for constraint, and it relies on the neural tangent kernel (NTK) of an infinitely wide network to build a proxy model. Though effective, the NTK cannot learn features because of its parametrization, and its use prevents the incorporation of powerful pre-trained Language Models (LMs) that can capture the rich biophysical information in millions of biological sequences. We adopt an alternative proxy model, adding a linear head to a pre-trained LM, and propose a linearization scheme. This yields a closed-form loss and also takes into account the biophysical information in the pre-trained LM. In addition, the forward mapping and the backward mapping play different roles and thus deserve different weights during sequence optimization. To achieve this, we train an auxiliary model and leverage its weak supervision signal via a bi-level optimization framework to effectively learn how to balance the two mappings. Further, by extending the framework, we develop the first learning rate adaptation module Adaptive-eta, which is compatible with all gradient-based algorithms for offline model-based optimization. Experimental results on DNA/protein sequence design tasks verify the effectiveness of our algorithm. Our code is available~https://anonymous.4open.science/r/BIB-ICLR2023-Submission/README.md{here.}

  • 4 authors
·
Jan 7, 2023

Mélange: Cost Efficient Large Language Model Serving by Exploiting GPU Heterogeneity

Large language models (LLMs) are increasingly integrated into many online services. However, a major challenge in deploying LLMs is their high cost, due primarily to the use of expensive GPU instances. To address this problem, we find that the significant heterogeneity of GPU types presents an opportunity to increase GPU cost efficiency and reduce deployment costs. The broad and growing market of GPUs creates a diverse option space with varying costs and hardware specifications. Within this space, we show that there is not a linear relationship between GPU cost and performance, and identify three key LLM service characteristics that significantly affect which GPU type is the most cost effective: model request size, request rate, and latency service-level objective (SLO). We then present M\'elange, a framework for navigating the diversity of GPUs and LLM service specifications to derive the most cost-efficient set of GPUs for a given LLM service. We frame the task of GPU selection as a cost-aware bin-packing problem, where GPUs are bins with a capacity and cost, and items are request slices defined by a request size and rate. Upon solution, M\'elange derives the minimal-cost GPU allocation that adheres to a configurable latency SLO. Our evaluations across both real-world and synthetic datasets demonstrate that M\'elange can reduce deployment costs by up to 77% as compared to utilizing only a single GPU type, highlighting the importance of making heterogeneity-aware GPU provisioning decisions for LLM serving. Our source code is publicly available at https://github.com/tyler-griggs/melange-release.

  • 7 authors
·
Apr 22, 2024

A Theoretical Study on Bridging Internal Probability and Self-Consistency for LLM Reasoning

Test-time scaling seeks to improve the reasoning performance of large language models (LLMs) by adding computational resources. A prevalent approach within the field is sampling-based test-time scaling methods, which enhance reasoning by generating multiple reasoning paths for a given input during inference. However, despite its practical success, the theoretical foundations remain underexplored. In this paper, we provide the first theoretical framework for analyzing sampling-based test-time scaling methods, grounded in the perspective of confidence estimation. Based on the framework, we analyze two dominant paradigms: self-consistency and perplexity, and reveal key limitations: self-consistency suffers from high estimation error while perplexity exhibits substantial modeling error and possible degradation of the estimation error convergence. To address these limitations, we introduce RPC, a hybrid method that leverages our theoretical insights through two key components: Perplexity Consistency and Reasoning Pruning. Perplexity Consistency combines the strengths of self-consistency and perplexity, boosting the convergence rate of estimation error from linear to exponential while preserving model error. Reasoning Pruning prevents degradation by eliminating low-probability reasoning paths. Both theoretical analysis and empirical results across seven benchmark datasets demonstrate that RPC has a strong potential for reducing reasoning error. Notably, RPC achieves reasoning performance comparable to self-consistency while not only enhancing confidence reliability but also reducing sampling costs by 50%. The code and resources are available at https://wnjxyk.github.io/RPC.

LAMDA-NeSy NJU-IRP
·
Oct 17, 2025 7

Neighbor Embedding for High-Dimensional Sparse Poisson Data

Across many scientific fields, measurements often represent the number of times an event occurs. For example, a document can be represented by word occurrence counts, neural activity by spike counts per time window, or online communication by daily email counts. These measurements yield high-dimensional count data that often approximate a Poisson distribution, frequently with low rates that produce substantial sparsity and complicate downstream analysis. A useful approach is to embed the data into a low-dimensional space that preserves meaningful structure, commonly termed dimensionality reduction. Yet existing dimensionality reduction methods, including both linear (e.g., PCA) and nonlinear approaches (e.g., t-SNE), often assume continuous Euclidean geometry, thereby misaligning with the discrete, sparse nature of low-rate count data. Here, we propose p-SNE (Poisson Stochastic Neighbor Embedding), a nonlinear neighbor embedding method designed around the Poisson structure of count data, using KL divergence between Poisson distributions to measure pairwise dissimilarity and Hellinger distance to optimize the embedding. We test p-SNE on synthetic Poisson data and demonstrate its ability to recover meaningful structure in real-world count datasets, including weekday patterns in email communication, research area clusters in OpenReview papers, and temporal drift and stimulus gradients in neural spike recordings.

  • 2 authors
·
Apr 17

AEGIS: Adversarial Entropy-Guided Immune System -- Thermodynamic State Space Models for Zero-Day Network Evasion Detection

As TLS 1.3 encryption limits traditional Deep Packet Inspection (DPI), the security community has pivoted to Euclidean Transformer-based classifiers (e.g., ET-BERT) for encrypted traffic analysis. However, these models remain vulnerable to byte-level adversarial morphing -- recent pre-padding attacks reduced ET-BERT accuracy to 25.68%, while VLESS Reality bypasses certificate-based detection entirely. We introduce AEGIS: an Adversarial Entropy-Guided Immune System powered by a Thermodynamic Variance-Guided Hyperbolic Liquid State Space Model (TVD-HL-SSM). Rather than competing in the Euclidean payload-reading domain, AEGIS discards payload bytes in favor of 6-dimensional continuous-time flow physics projected into a non-Euclidean Poincare manifold. Liquid Time-Constants measure microsecond IAT decay, and a Thermodynamic Variance Detector computes sequence-wide Shannon Entropy to expose automated C2 tunnel anomalies. A pure C++ eBPF Harvester with zero-copy IPC bypasses the Python GIL, enabling a linear-time O(N) Mamba-3 core to process 64,000-packet swarms at line-rate. Evaluated on a 400GB, 4-tier adversarial corpus spanning backbone traffic, IoT botnets, zero-days, and proprietary VLESS Reality tunnels, AEGIS achieves an F1-score of 0.9952 and 99.50% True Positive Rate at 262 us inference latency on an RTX 4090, establishing a new state-of-the-art for physics-based adversarial network defense.

  • 1 authors
·
Apr 1

Stochastic gradient descent on the epigenetic landscape: a unified framework for cellular plasticity, tumor heterogeneity, and the asymptotic irrelevance of fitness

Phenotypic plasticity, the ability of cells to switch between states, is central to development, differentiation, and therapy resistance. Although it is modeled at several scales, from compartmental ODEs to phenotype-structured PDEs and single-cell stochastic equations, a framework connecting these descriptions is missing. We present such a framework. Starting from a general n-compartment ODE model encompassing nonlinear growth and linear transitions between phenotypes, we show, with a new, elementary and generalizable proof of a recent theorem, that under uniform competition, the long-term population distribution is solely governed by transition rates. All phenotypes become selectively neutral at saturation, and the imprint of fitness differences during growth fades at an explicit rate. Restricting transitions to neighboring states transforms the model into a discretization of a phenotype-structured reaction-diffusion-advection PDE. In this continuum model, diffusion and advection are identified from switching rates, and fitness remains asymptotically irrelevant. Interpreting the advection velocity as the negative gradient of an effective epigenetic potential transforms the PDE into a Fokker--Planck equation and converts single-cell trajectories into stochastic gradient descent (SGD) in the Langevin sense on the phenotypic landscape. Non-local transitions, such as mutations, are incorporated via an integro-differential term, yielding a unified model with reaction, gradient flow, diffusion, and jumps. State-dependent noise reshapes the effective landscape without altering the underlying potential. This gives cancer a route to elevated plasticity that static, single-cell snapshots cannot distinguish from a changed landscape. This framework provides a physical interpretation of Waddington's landscape, where cells perform SGD, and cancer corresponds to a corrupted landscape.

  • 1 authors
·
Sep 28

Diffeomorphic Mesh Deformation via Efficient Optimal Transport for Cortical Surface Reconstruction

Mesh deformation plays a pivotal role in many 3D vision tasks including dynamic simulations, rendering, and reconstruction. However, defining an efficient discrepancy between predicted and target meshes remains an open problem. A prevalent approach in current deep learning is the set-based approach which measures the discrepancy between two surfaces by comparing two randomly sampled point-clouds from the two meshes with Chamfer pseudo-distance. Nevertheless, the set-based approach still has limitations such as lacking a theoretical guarantee for choosing the number of points in sampled point-clouds, and the pseudo-metricity and the quadratic complexity of the Chamfer divergence. To address these issues, we propose a novel metric for learning mesh deformation. The metric is defined by sliced Wasserstein distance on meshes represented as probability measures that generalize the set-based approach. By leveraging probability measure space, we gain flexibility in encoding meshes using diverse forms of probability measures, such as continuous, empirical, and discrete measures via varifold representation. After having encoded probability measures, we can compare meshes by using the sliced Wasserstein distance which is an effective optimal transport distance with linear computational complexity and can provide a fast statistical rate for approximating the surface of meshes. To the end, we employ a neural ordinary differential equation (ODE) to deform the input surface into the target shape by modeling the trajectories of the points on the surface. Our experiments on cortical surface reconstruction demonstrate that our approach surpasses other competing methods in multiple datasets and metrics.

  • 6 authors
·
May 27, 2023