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Oct 27

The Delegation Divide: An Open Index of AI-Agent Delegability across Occupations and Countries

35.2% of task time in world employment is at least partly delegable to AI agents in 2026, and only 2.5% can be handed over in full. Existing measures score exposure to generative AI, mostly for the United States. We build the Agent Delegability Index (ADI): two language models rate all 18,796 O*NET 30.2 task statements on a frozen, preregistered rubric of delegation levels and barriers; tasks are mapped to 433 ISCO-08 unit groups and weighted by ILOSTAT employment in 146 countries. Four findings. First, delegable employment rises with income, from 22.5% in low-income to 48.7% in high-income countries, a slope of 7.23 percentage points per log point of GDP per capita. This delegation divide is compositional: the physical barrier dominates the jobs poorer countries employ most. Second, at the occupation level ADI tracks exposure closely (r = 0.93 with Eloundou et al. and 0.89 with Felten et al.), above the preregistered bound of 0.80; ADI adds delegation levels and barriers on top of exposure, for the world, not a new ranking of occupations. Third, full delegation is rare and peaks for tasks that take a human about twelve minutes (11.8 minutes). Fourth, the preregistered adoption gap is not supported: across 101 countries, delegability and observed AI usage correlate at r = 0.86, and the gap between them is not wider in middle-income countries (p = 0.27). Model agreement is kappa = 0.77; a blind human rating of 300 tasks agrees with the model consensus at kappa = 0.85, and an agentic panel with web search at kappa = 0.87. We release the index, the atlas, the prompts and an MCP server at https://github.com/Cespial/delegation-divide.

  • 2 authors
·
Oct 21

World Simulation with Video Foundation Models for Physical AI

We introduce [Cosmos-Predict2.5], the latest generation of the Cosmos World Foundation Models for Physical AI. Built on a flow-based architecture, [Cosmos-Predict2.5] unifies Text2World, Image2World, and Video2World generation in a single model and leverages [Cosmos-Reason1], a Physical AI vision-language model, to provide richer text grounding and finer control of world simulation. Trained on 200M curated video clips and refined with reinforcement learning-based post-training, [Cosmos-Predict2.5] achieves substantial improvements over [Cosmos-Predict1] in video quality and instruction alignment, with models released at 2B and 14B scales. These capabilities enable more reliable synthetic data generation, policy evaluation, and closed-loop simulation for robotics and autonomous systems. We further extend the family with [Cosmos-Transfer2.5], a control-net style framework for Sim2Real and Real2Real world translation. Despite being 3.5times smaller than [Cosmos-Transfer1], it delivers higher fidelity and robust long-horizon video generation. Together, these advances establish [Cosmos-Predict2.5] and [Cosmos-Transfer2.5] as versatile tools for scaling embodied intelligence. To accelerate research and deployment in Physical AI, we release source code, pretrained checkpoints, and curated benchmarks under the NVIDIA Open Model License at https://github.com/nvidia-cosmos/cosmos-predict2.5 and https://github.com/nvidia-cosmos/cosmos-transfer2.5. We hope these open resources lower the barrier to adoption and foster innovation in building the next generation of embodied intelligence.

  • 89 authors
·
Oct 28, 2025 1

MD-LLM-2: A Transferable Language Model of Molecular Dynamics with Physical Conditioning and Explicit Path Probabilities

Molecular dynamics (MD) simulations model the motion of proteins between conformational states, but crossing free energy barriers and sampling multiple thermodynamic conditions remain computationally costly. We recently introduced MD-LLM-1, which showed that language models can generate conformational trajectories at lower cost, but required a separate model for each protein and did not explicitly model thermodynamics or kinetics. Here we introduce MD-LLM-2, a transferable language model that generates trajectories conditioned on sequence, temperature and molecular history. Because each step defines a normalized distribution over structural tokens, the model assigns an explicit likelihood to every generated or simulated trajectory. Trained across mdCATH domains, MD-LLM-2 reproduces the median radius of gyration of MD within 1 Angstrom in 10 of 12 unseen domains, predicts reduced Trp-cage compaction at higher temperature, and generates L99A T4 lysozyme trajectories that reach published transition-region backbone structures. In alanine dipeptide simulations, conditioning on a torsional scaling parameter λ predicts basin populations at unseen couplings with a mean absolute error of 0.09 versus 0.35 for MBAR, and first-passage probabilities with an error of 0.08 versus 0.16 for a reversible Markov state model. Frame-isoentropic sampling further limits the accumulation of errors during autoregressive trajectory generation. Together, these results extend MD-LLM from protein-specific trajectory generation to transferable, physically conditioned modelling with explicit path likelihoods, and show that the framework can predict equilibrium populations for force-field parameters not seen during training, with an initial indication that first-passage kinetics can also be captured.

  • 3 authors
·
Oct 6

A Comparative Study in Surgical AI: Datasets, Foundation Models, and Barriers to Med-AGI

Recent Artificial Intelligence (AI) models have matched or exceeded human experts in several benchmarks of biomedical task performance, but have lagged behind on surgical image-analysis benchmarks. Since surgery requires integrating disparate tasks -- including multimodal data integration, human interaction, and physical effects -- generally-capable AI models could be particularly attractive as a collaborative tool if performance could be improved. On the one hand, the canonical approach of scaling architecture size and training data is attractive, especially since there are millions of hours of surgical video data generated per year. On the other hand, preparing surgical data for AI training requires significantly higher levels of professional expertise, and training on that data requires expensive computational resources. These trade-offs paint an uncertain picture of whether and to-what-extent modern AI could aid surgical practice. In this paper, we explore this question through a case study of surgical tool detection using state-of-the-art AI methods available in 2026. We demonstrate that even with multi-billion parameter models and extensive training, current Vision Language Models fall short in the seemingly simple task of tool detection in neurosurgery. Additionally, we show scaling experiments indicating that increasing model size and training time only leads to diminishing improvements in relevant performance metrics. Thus, our experiments suggest that current models could still face significant obstacles in surgical use cases. Moreover, some obstacles cannot be simply ``scaled away'' with additional compute and persist across diverse model architectures, raising the question of whether data and label availability are the only limiting factors. We discuss the main contributors to these constraints and advance potential solutions.

edible polysaccharides as stabilizers and carriers for the delivery of phenolic compounds and pigments in food formulations

Food polysaccharides have emerged as suitable carriers of active substances and as additives to food and nutraceutical formulations, showing potential to stabilize bioactive compounds during the storage of microencapsulate preparations, even in the gastrointestinal tract following the intake of bioactive compounds, thereby improving their bioaccessibility and bioavailability. This review provides a comprehensive overview of the main polysaccharides employed as wall materials, including starch, maltodextrin, alginate, pectin, inulin, chitosan, and gum arabic, and discusses how structural interactions and physicochemical properties can benefit the microencapsulation of polyphenols and pigments. The main findings and principles of the major encapsulation techniques, including spray drying, freeze drying, extrusion, emulsification, and coacervation, related to the production of microparticles, were briefly described. Polysaccharides can entrap hydrophilic and hydrophobic compounds by physical interactions, forming a barrier around the nucleus or binding to the bioactive compound. Intermolecular binding between polysaccharides in the wall matrix, polyphenols, and pigments in the nucleus can confer up to 90% of encapsulation efficiency, governed mainly by hydrogen bonds and electrostatic interactions. The mixture of wall polysaccharides in the microparticles synthesis favors the encapsulation solubility, storage stability, bioaccessibility, and bioactivity of the microencapsulate compounds. Clinical trials on the bioefficacy of polyphenols and pigments loaded in polysaccharide microparticles are scarce and require further evidence to reinforce the use of this technology.

  • 7 authors
·
Nov 10, 2025

DexViTac: Collecting Human Visuo-Tactile-Kinematic Demonstrations for Contact-Rich Dexterous Manipulation

Large-scale, high-quality multimodal demonstrations are essential for robot learning of contact-rich dexterous manipulation. While human-centric data collection systems lower the barrier to scaling, they struggle to capture the tactile information during physical interactions. Motivated by this, we present DexViTac, a portable, human-centric data collection system tailored for contact-rich dexterous manipulation. The system enables the high-fidelity acquisition of first-person vision, high-density tactile sensing, end-effector poses, and hand kinematics within unstructured, in-the-wild environments. Building upon this hardware, we propose a kinematics-grounded tactile representation learning algorithm that effectively resolves semantic ambiguities within tactile signals. Leveraging the efficiency of DexViTac, we construct a multimodal dataset comprising over 2,400 visuo-tactile-kinematic demonstrations. Experiments demonstrate that DexViTac achieves a collection efficiency exceeding 248 demonstrations per hour and remains robust against complex visual occlusions. Real-world deployment confirms that policies trained with the proposed dataset and learning strategy achieve an average success rate exceeding 85% across four challenging tasks. This performance significantly outperforms baseline methods, thereby validating the substantial improvement the system provides for learning contact-rich dexterous manipulation. Project page: https://xitong-c.github.io/DexViTac/.

  • 4 authors
·
Mar 17

Deep Learning to Automate Parameter Extraction and Model Fitting of Two-Dimensional Transistors

We present a deep learning approach to extract physical parameters (e.g., mobility, Schottky contact barrier height, defect profiles) of two-dimensional (2D) transistors from electrical measurements, enabling automated parameter extraction and technology computer-aided design (TCAD) fitting. To facilitate this task, we implement a simple data augmentation and pre-training approach by training a secondary neural network to approximate a physics-based device simulator. This method enables high-quality fits after training the neural network on electrical data generated from physics-based simulations of ~500 devices, a factor >40times fewer than other recent efforts. Consequently, fitting can be achieved by training on physically rigorous TCAD models, including complex geometry, self-consistent transport, and electrostatic effects, and is not limited to computationally inexpensive compact models. We apply our approach to reverse-engineer key parameters from experimental monolayer WS_2 transistors, achieving a median coefficient of determination (R^2) = 0.99 when fitting measured electrical data. We also demonstrate that this approach generalizes and scales well by reverse-engineering electrical data on high-electron-mobility transistors while fitting 35 parameters simultaneously. To facilitate future research on deep learning approaches for inverse transistor design, we have published our code and sample data sets online.

  • 11 authors
·
Sep 4

RoboGesture: Real-Time Semantic-aligned Co-Speech Gestures Generation for Humanoid Interaction

Enabling humanoid robots to respond to human speech with synchronized and semantically meaningful gestures is fundamental to natural human-robot interaction. However, this task faces three critical barriers: the scarcity of semantically rich datasets, the "modality eclipse" where models ignore audio cues in favor of kinematic inertia, and the sim-to-real gap regarding physical safety. We propose RoboGesture, a robot-centric framework that co-designs data, modeling, and control to power a complete interactive human-humanoid system in which the robot listens, responds, and gestures in real time. We first establish the RoboGesture dataset featuring over 300 gesture categories and develop an automated pipeline to synthesize large-scale collision-free, robot-specific audio-motion pairs. Our architecture features a Hierarchical Semantic-Acoustic Aligner that extracts multi-granular prosodic and semantic cues directly from raw audio tokens. These cues drive a Streaming Conditional Motion Generator based on a diffusion transformer with conditional flow matching. To ensure high responsiveness, we introduce Anti-Inertia CFG Masking, which prevents the model from collapsing into repetitive historical patterns by compelling it to proactively mine control signals from the audio modality. Finally, an MPC-based safety filter ensures real-time, collision-free execution on physical hardware. Experiments on a Unitree G1 humanoid demonstrate that RoboGesture generates safer, more rhythmic, and more semantically appropriate responses compared to state-of-the-art baselines.

  • 10 authors
·
Aug 26

Enhanced Performance of Highly Activated Carbon and Surface-Treated Porous Polymers as Physical Adsorbents for Chemical Warfare Agents

The use of chemical warfare agents (CWAs) in modern warfare cannot be disregarded due to their ease of use and potential for large-scale incapacitation. An effective countermeasure involves the physical adsorption of these agents, preventing their entry through the respiratory tract by non-specific adsorption. In this study, we investigate the physical interaction between potential adsorbents and model gases mimicking CWAs, thereby identifying sufficient conditions for higher physical adsorption performance. Our findings reveal that the physical adsorption capacity is highly sensitive to the surface properties of the adsorbents, with uniform development of micropores, rather than solely high surface area, emerging as a critical factor. Additionally, we identified the potential of porous organic polymers as promising alternatives to conventional activated carbon-based adsorbents. Through a facile introduction of polar sulfone functional groups on the polymer surface, we demonstrated that these polar surface polymers exhibit physical adsorption capabilities for formaldehyde under ambient conditions comparable to high-performance activated carbons. Notably, the superior activated carbon possessed a high BET surface area of 2400 m^2/g and an exceptionally uniform micropore structure with an average pore size of approximately 11 Angstroms. This research paves the way for designing adsorbents with high physical adsorption capacities tailored for CWAs protection, offering a significant advancement in developing next-generation protective materials.

  • 3 authors
·
May 10, 2025