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Oct 16

ConnectomeBench2: A Unified Benchmark for Automated Connectomic Proofreading

Proofreading--correcting segmentation errors in 3D brain reconstructions--is the rate-limiting step in synapse-resolution connectomics. We release ConnectomeBench2, a unified multi-species dataset of over 716,485 expert-labeled proofreading decisions with >4,500,000 associated images spanning four major open connectomes (mouse, human, zebrafish, fly), spanning both split and merge error correction. Trained on this dataset, a single Vision Transformer with shared encoders for mesh geometry and electron microscopy reaches human-level accuracy across species for split error correction and merge error identification, with performance scaling with data size and modality. Beyond accuracy, we show that the model is well-calibrated within distribution, that measures of distribution distance predict where calibration and accuracy will degrade on unseen data, and that connectomics-specific pretraining and active learning-based sample selection show potential to substantially reduce the labeling effort needed to extend to new species and brain regions. The benchmark provides the infrastructure to train and evaluate increasingly capable vision models for connectomic proofreading. Data and code availability. The ConnectomeBench2 dataset is released on Hugging Face at https://huggingface.co/datasets/jeffbbrown2/ConnectomeBench2. The accompanying codebase is available on GitHub at https://github.com/timfarkas/ConnectomeBench2.

  • 4 authors
·
Jun 18

A Multi-Pass Large Language Model Framework for Precise and Efficient Radiology Report Error Detection

Background: The positive predictive value (PPV) of large language model (LLM)-based proofreading for radiology reports is limited due to the low error prevalence. Purpose: To assess whether a three-pass LLM framework enhances PPV and reduces operational costs compared with baseline approaches. Materials and Methods: A retrospective analysis was performed on 1,000 consecutive radiology reports (250 each: radiography, ultrasonography, CT, MRI) from the MIMIC-III database. Two external datasets (CheXpert and Open-i) were validation sets. Three LLM frameworks were tested: (1) single-prompt detector; (2) extractor plus detector; and (3) extractor, detector, and false-positive verifier. Precision was measured by PPV and absolute true positive rate (aTPR). Efficiency was calculated from model inference charges and reviewer remuneration. Statistical significance was tested using cluster bootstrap, exact McNemar tests, and Holm-Bonferroni correction. Results: Framework PPV increased from 0.063 (95% CI, 0.036-0.101, Framework 1) to 0.079 (0.049-0.118, Framework 2), and significantly to 0.159 (0.090-0.252, Framework 3; P<.001 vs. baselines). aTPR remained stable (0.012-0.014; P>=.84). Operational costs per 1,000 reports dropped to USD 5.58 (Framework 3) from USD 9.72 (Framework 1) and USD 6.85 (Framework 2), reflecting reductions of 42.6% and 18.5%, respectively. Human-reviewed reports decreased from 192 to 88. External validation supported Framework 3's superior PPV (CheXpert 0.133, Open-i 0.105) and stable aTPR (0.007). Conclusion: A three-pass LLM framework significantly enhanced PPV and reduced operational costs, maintaining detection performance, providing an effective strategy for AI-assisted radiology report quality assurance.

  • 6 authors
·
Jun 24, 2025

SciCode-Verified: How Benchmark Defects Underestimated the Scientific-Coding Ability of Language Models

SciCode is the standard measure of the scientific-coding ability of language models: research-level problems that demand both frontier scientific theory and its implementation as working numerical code. It is a component of the Artificial Analysis Intelligence Index and a standing evaluation in government and national-laboratory suites. Yet its scores have recently plateaued: the strongest 2026 models cluster tightly around 60\% subproblem accuracy, and a successor model ties its predecessor. We trace this stagnation to defects in the benchmark itself. A per-problem, domain-expert audit of all 65 test problems uncovers 263 defects; 192 of them, spread across 91\% of the main problems, cause correct, instruction-following solutions to be wrongly rejected---through non-reproducible gold answers, over-tight tolerances, or self-contradictory specifications. Critically, 78\% of these score-suppressing defects require specialized physics or mathematics knowledge to detect, not mere clerical proofreading. We corrected every confirmable defect to produce SciCode-Verified. The corrections add only the specifications a well-posed problem requires, repair grading, and tighten the tests that were too lenient; every change is recorded with its justification and independently re-checked by a second domain expert. We re-evaluate twelve frontier model snapshots on the corrected benchmark and find a substantial recovery: subproblem accuracy rises from 45--60\% to 84--98\%, and main-problem accuracy from 9--27\% to 69--92\%. State-of-the-art models are far more proficient in scientific coding than SciCode has suggested---the bottleneck was not model capability, but the quality of the evaluation instrument. We release SciCode-Verified with its complete audit trail as the corrected public standard.

  • 4 authors
·
Aug 4