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Oct 29

SCORPION: Addressing Scanner-Induced Variability in Histopathology

Ensuring reliable model performance across diverse domains is a critical challenge in computational pathology. A particular source of variability in Whole-Slide Images is introduced by differences in digital scanners, thus calling for better scanner generalization. This is critical for the real-world adoption of computational pathology, where the scanning devices may differ per institution or hospital, and the model should not be dependent on scanner-induced details, which can ultimately affect the patient's diagnosis and treatment planning. However, past efforts have primarily focused on standard domain generalization settings, evaluating on unseen scanners during training, without directly evaluating consistency across scanners for the same tissue. To overcome this limitation, we introduce SCORPION, a new dataset explicitly designed to evaluate model reliability under scanner variability. SCORPION includes 480 tissue samples, each scanned with 5 scanners, yielding 2,400 spatially aligned patches. This scanner-paired design allows for the isolation of scanner-induced variability, enabling a rigorous evaluation of model consistency while controlling for differences in tissue composition. Furthermore, we propose SimCons, a flexible framework that combines augmentation-based domain generalization techniques with a consistency loss to explicitly address scanner generalization. We empirically show that SimCons improves model consistency on varying scanners without compromising task-specific performance. By releasing the SCORPION dataset and proposing SimCons, we provide the research community with a crucial resource for evaluating and improving model consistency across diverse scanners, setting a new standard for reliability testing.

  • 7 authors
·
Sep 17, 2025

Rethinking MCP Security: A Large-Scale Study of Runtime MCP Servers and Security Scanner Reliability

The Model Context Protocol (MCP) has rapidly established itself as a standard interface for enabling LLM-based agents to interact with external tools and services. As MCP servers are increasingly entrusted with security-sensitive operations, understanding their real-world risks has become critical. In practice, due to the absence of large-scale runtime MCP servers, such understanding largely relies on security scanners applied to a small number of cases, yet the reliability of these assessments remains unclear. In this study, we revisit how MCP security is measured. We present MCPZoo, the largest collection of MCP servers for dynamic analysis to date. MCPZoo is constructed through a multi-agent framework for transforming in-the-wild static repositories into dynamic services. The framework emulates how human experts build, diagnose, and iteratively repair deployment and runtime defects by combining environment inference with feedback-driven refinement. To ensure practical interactivity at runtime, the servers are validated via real protocol interactions. As a result, MCPZoo contains 64,611 unique MCP servers (113,927 in total), with more than 37,288 supporting dynamic analysis. Leveraging MCPZoo, we conduct the first ecosystem-scale measurement of MCP servers and the scanners that analyze them. While existing scanners report that 96.89% of servers are risky, we find that these signals are unreliable. In particular, manual validation shows that less than 50% of sampled alerts are true positives, and scanner outputs exhibit clear inconsistency across scanners. Overall, MCPZoo enables large-scale, reproducible measurement of MCP server security and exposes limitations of current scanning practices. We further release a public query interface to support practical risk assessment of MCP servers.

  • 9 authors
·
Jul 12

Cloak and Detonate: Scanner Evasion and Dynamic Detection of Agent Skill Malware

LLM coding agents increasingly rely on third-party agent skills from public marketplaces, which execute with the agent's privileges and create a software supply-chain attack surface: a malicious skill can steal credentials, exfiltrate source code, or install backdoors. Existing defenses use static skill scanners based on pattern matching or LLM-as-judge analysis, but it remains unclear whether they withstand adaptive evasions that preserve malicious behavior while changing payload appearance. This paper first presents an adversarial study of existing skill scanners through SkillCloak, a payload-preserving evasion framework that keeps the attack semantics intact while transforming their visible form. SkillCloak uses two complementary strategies: Structural Obfuscation, which rewrites visible payload indicators into semantically equivalent forms, and Self-Extracting Skill (SFS) Packing, which hides malicious components from the install-time view and restores them during agent execution. Across eight scanners and 1,613 in-the-wild malicious skills, SFS Packing bypasses every scanner at over 90%, while Structural Obfuscation bypasses over 80% on most static scanners and reaches 96% on a hybrid scanner, showing that appearance-based auditing is insufficient. Motivated by this finding, we propose SkillDetonate, a behavior-centric runtime auditor that executes skills in a sandbox and detects malicious effects through OS-boundary information-flow evidence rather than install-time appearance. SkillDetonate combines on-demand closure lift, which observes instructions materialized during execution, with marker-based taint analysis, which tracks sensitive-data flows across the agent context, files, processes, and network operations. The results show that SkillDetonate detects 97% of attacks at a 2% false-positive rate and sustains 87% detection on real-world malicious skills.

  • 7 authors
·
Jul 2

BRANCH: Bypassing Multi-Scanner AI Guardrails

AI systems increasingly rely on Large Language Models (LLMs) as core reasoning engines, making them targets for prompt injection and jailbreaks. Guardrails monitor and validate model inputs and outputs, yet their isolated, task-focused detection leaves gaps in their classification making them susceptible to bypasses. In response, guardrail systems formed by multiple scanners have emerged that collaboratively detect different types of malicious instructions, whereby shared latent representations across classification boundaries render established bypassing techniques ineffective. We propose BRANCH, a bypassing methodology designed for multi-scanner guardrail systems. Our method leverages a branching tree search approach that dynamically applies adversarial perturbation against individual scanners, with subsequent perturbation optimization and technique selection based on overall improvement across all guardrail system scanners, effectively decoupling bypass evaluation from attack signal optimization. Our findings demonstrate that BRANCH achieves 100% attack success rate across 6 guardrail systems in 120 scenarios with 72% fewer queries and 4.5x reduced wallclock time compared to established techniques, while preserving semantic meaning within the bypass. We also show how bypasses generated by BRANCH transfer to 29 unseen guardrails, including 8 commercial black-box guardrails, improving attack success in some cases up to 100% with no additional optimization.

  • 2 authors
·
Oct 6

CompoSkill: Compositional Skill Chain Attacks from Individually Scanner-Passing LLM Agent Skills

Autonomous AI agents tackling Long Horizon Tasks depend on marketplace skills that are certified one at a time: a scanner returns a safety verdict for each skill and declares the ecosystem safe if every package passes. We show that this assumption fails under skill composition. A skill may pass the per-skill scanner individually yet participate in a risky composition when an agent connects its outputs, capabilities, or side effects with those of other scanner-passing skills. This makes skill composition risk a path level property rather than a node level property, explaining why existing skill scanners that inspect individual packages achieve limited interception. To study this threat, we present CompoSkill, a framework that constructs skill composition attacks through a dual attacker system. The white-box attacker knows the victim's installed skill pool and directly injects explicit skill-id sequences; the black-box attacker knows only a role profile, downloads the top marketplace skills for that scenario, builds a Skill Composition Graph, and searches for high risk chains whose implicit lures never name skill identifiers. We further construct CompoSkill-Bench, a benchmark of 1,140 records built from long-horizon professional workflows across five threats and six scenarios on OpenClaw and Nanobot. CompoSkill achieves risk Chain Formation Rates (CFR) up to 83.3% in the white box setting and 80.6% in the black box setting, while existing skill scanners block only a limited fraction of the risky compositions. Finally, we observe a bridge-bonus-then-hop-decay pattern: a bridge skill can increase attack success, but Attack Success Rate (ASR) decreases once additional hops make the risk chain longer than three skills. These results expose a systematic gap in single skill certification for autonomous AI agents.

  • 7 authors
·
Aug 16

Explainable AI for Accelerated Microstructure Imaging: A SHAP-Guided Protocol on the Connectome 2.0 scanner

The diffusion MRI Neurite Exchange Imaging model offers a promising framework for probing gray matter microstructure by estimating parameters such as compartment sizes, diffusivities, and inter-compartmental water exchange time. However, existing protocols require long scan times. This study proposes a reduced acquisition scheme for the Connectome 2.0 scanner that preserves model accuracy while substantially shortening scan duration. We developed a data-driven framework using explainable artificial intelligence with a guided recursive feature elimination strategy to identify an optimal 8-feature subset from a 15-feature protocol. The performance of this optimized protocol was validated in vivo and benchmarked against the full acquisition and alternative reduction strategies. Parameter accuracy, preservation of anatomical contrast, and test-retest reproducibility were assessed. The reduced protocol yielded parameter estimates and cortical maps comparable to the full protocol, with low estimation errors in synthetic data and minimal impact on test-retest variability. Compared to theory-driven and heuristic reduction schemes, the optimized protocol demonstrated superior robustness, reducing the deviation in water exchange time estimates by over two-fold. In conclusion, this hybrid optimization framework enables viable imaging of neurite exchange in 14 minutes without loss of parameter fidelity. This approach supports the broader application of exchange-sensitive diffusion magnetic resonance imaging in neuroscience and clinical research, and offers a generalizable method for designing efficient acquisition protocols in biophysical parameter mapping.

  • 13 authors
·
Sep 11, 2025