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Aug 6

An Overview of Diffusion Models: Applications, Guided Generation, Statistical Rates and Optimization

Diffusion models, a powerful and universal generative AI technology, have achieved tremendous success in computer vision, audio, reinforcement learning, and computational biology. In these applications, diffusion models provide flexible high-dimensional data modeling, and act as a sampler for generating new samples under active guidance towards task-desired properties. Despite the significant empirical success, theory of diffusion models is very limited, potentially slowing down principled methodological innovations for further harnessing and improving diffusion models. In this paper, we review emerging applications of diffusion models, understanding their sample generation under various controls. Next, we overview the existing theories of diffusion models, covering their statistical properties and sampling capabilities. We adopt a progressive routine, beginning with unconditional diffusion models and connecting to conditional counterparts. Further, we review a new avenue in high-dimensional structured optimization through conditional diffusion models, where searching for solutions is reformulated as a conditional sampling problem and solved by diffusion models. Lastly, we discuss future directions about diffusion models. The purpose of this paper is to provide a well-rounded theoretical exposure for stimulating forward-looking theories and methods of diffusion models.

  • 4 authors
·
Apr 11, 2024

Statistical Perspective of Top-K Sparse Softmax Gating Mixture of Experts

Top-K sparse softmax gating mixture of experts has been widely used for scaling up massive deep-learning architectures without increasing the computational cost. Despite its popularity in real-world applications, the theoretical understanding of that gating function has remained an open problem. The main challenge comes from the structure of the top-K sparse softmax gating function, which partitions the input space into multiple regions with distinct behaviors. By focusing on a Gaussian mixture of experts, we establish theoretical results on the effects of the top-K sparse softmax gating function on both density and parameter estimations. Our results hinge upon defining novel loss functions among parameters to capture different behaviors of the input regions. When the true number of experts k_{ast} is known, we demonstrate that the convergence rates of density and parameter estimations are both parametric on the sample size. However, when k_{ast} becomes unknown and the true model is over-specified by a Gaussian mixture of k experts where k > k_{ast}, our findings suggest that the number of experts selected from the top-K sparse softmax gating function must exceed the total cardinality of a certain number of Voronoi cells associated with the true parameters to guarantee the convergence of the density estimation. Moreover, while the density estimation rate remains parametric under this setting, the parameter estimation rates become substantially slow due to an intrinsic interaction between the softmax gating and expert functions.

  • 4 authors
·
Sep 24, 2023

Statistical Estimation of Adversarial Risk in Large Language Models under Best-of-N Sampling

Large Language Models (LLMs) are typically evaluated for safety under single-shot or low-budget adversarial prompting, which underestimates real-world risk. In practice, attackers can exploit large-scale parallel sampling to repeatedly probe a model until a harmful response is produced. While recent work shows that attack success increases with repeated sampling, principled methods for predicting large-scale adversarial risk remain limited. We propose a scaling-aware Best-of-N estimation of risk, SABER, for modeling jailbreak vulnerability under Best-of-N sampling. We model sample-level success probabilities using a Beta distribution, the conjugate prior of the Bernoulli distribution, and derive an analytic scaling law that enables reliable extrapolation of large-N attack success rates from small-budget measurements. Using only n=100 samples, our anchored estimator predicts ASR@1000 with a mean absolute error of 1.66, compared to 12.04 for the baseline, which is an 86.2% reduction in estimation error. Our results reveal heterogeneous risk scaling profiles and show that models appearing robust under standard evaluation can experience rapid nonlinear risk amplification under parallel adversarial pressure. This work provides a low-cost, scalable methodology for realistic LLM safety assessment. We will release our code and evaluation scripts upon publication to future research.

microsoft Microsoft
·
Jan 30 3

Deep learning probability flows and entropy production rates in active matter

Active matter systems, from self-propelled colloids to motile bacteria, are characterized by the conversion of free energy into useful work at the microscopic scale. These systems generically involve physics beyond the reach of equilibrium statistical mechanics, and a persistent challenge has been to understand the nature of their nonequilibrium states. The entropy production rate and the magnitude of the steady-state probability current provide quantitative ways to do so by measuring the breakdown of time-reversal symmetry and the strength of nonequilibrium transport of measure. Yet, their efficient computation has remained elusive, as they depend on the system's unknown and high-dimensional probability density. Here, building upon recent advances in generative modeling, we develop a deep learning framework that estimates the score of this density. We show that the score, together with the microscopic equations of motion, gives direct access to the entropy production rate, the probability current, and their decomposition into local contributions from individual particles, spatial regions, and degrees of freedom. To represent the score, we introduce a novel, spatially-local transformer-based network architecture that learns high-order interactions between particles while respecting their underlying permutation symmetry. We demonstrate the broad utility and scalability of the method by applying it to several high-dimensional systems of interacting active particles undergoing motility-induced phase separation (MIPS). We show that a single instance of our network trained on a system of 4096 particles at one packing fraction can generalize to other regions of the phase diagram, including systems with as many as 32768 particles. We use this observation to quantify the spatial structure of the departure from equilibrium in MIPS as a function of the number of particles and the packing fraction.

  • 2 authors
·
Sep 22, 2023

Learning Unnormalized Statistical Models via Compositional Optimization

Learning unnormalized statistical models (e.g., energy-based models) is computationally challenging due to the complexity of handling the partition function. To eschew this complexity, noise-contrastive estimation~(NCE) has been proposed by formulating the objective as the logistic loss of the real data and the artificial noise. However, as found in previous works, NCE may perform poorly in many tasks due to its flat loss landscape and slow convergence. In this paper, we study it a direct approach for optimizing the negative log-likelihood of unnormalized models from the perspective of compositional optimization. To tackle the partition function, a noise distribution is introduced such that the log partition function can be written as a compositional function whose inner function can be estimated with stochastic samples. Hence, the objective can be optimized by stochastic compositional optimization algorithms. Despite being a simple method, we demonstrate that it is more favorable than NCE by (1) establishing a fast convergence rate and quantifying its dependence on the noise distribution through the variance of stochastic estimators; (2) developing better results for one-dimensional Gaussian mean estimation by showing our objective has a much favorable loss landscape and hence our method enjoys faster convergence; (3) demonstrating better performance on multiple applications, including density estimation, out-of-distribution detection, and real image generation.

  • 6 authors
·
Jun 12, 2023

Conformal Segmentation in Industrial Surface Defect Detection with Statistical Guarantees

In industrial settings, surface defects on steel can significantly compromise its service life and elevate potential safety risks. Traditional defect detection methods predominantly rely on manual inspection, which suffers from low efficiency and high costs. Although automated defect detection approaches based on Convolutional Neural Networks(e.g., Mask R-CNN) have advanced rapidly, their reliability remains challenged due to data annotation uncertainties during deep model training and overfitting issues. These limitations may lead to detection deviations when processing the given new test samples, rendering automated detection processes unreliable. To address this challenge, we first evaluate the detection model's practical performance through calibration data that satisfies the independent and identically distributed (i.i.d) condition with test data. Specifically, we define a loss function for each calibration sample to quantify detection error rates, such as the complement of recall rate and false discovery rate. Subsequently, we derive a statistically rigorous threshold based on a user-defined risk level to identify high-probability defective pixels in test images, thereby constructing prediction sets (e.g., defect regions). This methodology ensures that the expected error rate (mean error rate) on the test set remains strictly bounced by the predefined risk level. Additionally, we observe a negative correlation between the average prediction set size and the risk level on the test set, establishing a statistically rigorous metric for assessing detection model uncertainty. Furthermore, our study demonstrates robust and efficient control over the expected test set error rate across varying calibration-to-test partitioning ratios, validating the method's adaptability and operational effectiveness.

  • 2 authors
·
Apr 23, 2025

How Eviction Court Governs: A Statistical Analysis of Bargaining, Templates, and Debt in Philadelphia

We analyze downstream courtroom governance in Philadelphia eviction cases using 755,004 Municipal Court landlord--tenant records filed from 1969 through 2022. Post-filing case processing is organized by repeated courtroom relationships, judge and tenant-attorney regimes, reusable agreement templates, and repeated team-property units. Among both-represented, both-attorney-named cases, 58.2% involve a plaintiff-side and tenant-side attorney pair that had appeared against one another in the prior year, and greater prior pair exposure predicts lower default, higher judgment-by-agreement, and higher served-writ rates. Judge-linked cases display statistically distinct baseline outcome, continuance, fee, and award regimes; tenant-attorney identity explains meaningful variance in both case outcomes and agreement terms. Settlement text is highly standardized: reusable templates explain strictness, waiver, lockout-trigger, payment-plan, deadline, and time-is-essence language far more strongly than raw attorney identity. Monetary burden concentrates in repeated plaintiff-attorney-property units. Assignment-cell support and balance audits indicate that judge-linked evidence reflects institutional heterogeneity rather than a clean judge lottery, and judge--triad interactions are not estimable in this docket. Eviction court emerges as a repeated institutional field that organizes bargaining, text, debt, and enforcement after cases enter the courtroom pipeline.

  • 2 authors
·
May 23

A Hybrid Framework for Real-Time Data Drift and Anomaly Identification Using Hierarchical Temporal Memory and Statistical Tests

Data Drift is the phenomenon where the generating model behind the data changes over time. Due to data drift, any model built on the past training data becomes less relevant and inaccurate over time. Thus, detecting and controlling for data drift is critical in machine learning models. Hierarchical Temporal Memory (HTM) is a machine learning model developed by Jeff Hawkins, inspired by how the human brain processes information. It is a biologically inspired model of memory that is similar in structure to the neocortex, and whose performance is claimed to be comparable to state of the art models in detecting anomalies in time series data. Another unique benefit of HTMs is its independence from training and testing cycle; all the learning takes place online with streaming data and no separate training and testing cycle is required. In sequential learning paradigm, Sequential Probability Ratio Test (SPRT) offers some unique benefit for online learning and inference. This paper proposes a novel hybrid framework combining HTM and SPRT for real-time data drift detection and anomaly identification. Unlike existing data drift methods, our approach eliminates frequent retraining and ensures low false positive rates. HTMs currently work with one dimensional or univariate data. In a second study, we also propose an application of HTM in multidimensional supervised scenario for anomaly detection by combining the outputs of multiple HTM columns, one for each dimension of the data, through a neural network. Experimental evaluations demonstrate that the proposed method outperforms conventional drift detection techniques like the Kolmogorov-Smirnov (KS) test, Wasserstein distance, and Population Stability Index (PSI) in terms of accuracy, adaptability, and computational efficiency. Our experiments also provide insights into optimizing hyperparameters for real-time deployment in domains such as Telecom.

  • 3 authors
·
Apr 24, 2025

FNSPID: A Comprehensive Financial News Dataset in Time Series

Financial market predictions utilize historical data to anticipate future stock prices and market trends. Traditionally, these predictions have focused on the statistical analysis of quantitative factors, such as stock prices, trading volumes, inflation rates, and changes in industrial production. Recent advancements in large language models motivate the integrated financial analysis of both sentiment data, particularly market news, and numerical factors. Nonetheless, this methodology frequently encounters constraints due to the paucity of extensive datasets that amalgamate both quantitative and qualitative sentiment analyses. To address this challenge, we introduce a large-scale financial dataset, namely, Financial News and Stock Price Integration Dataset (FNSPID). It comprises 29.7 million stock prices and 15.7 million time-aligned financial news records for 4,775 S&P500 companies, covering the period from 1999 to 2023, sourced from 4 stock market news websites. We demonstrate that FNSPID excels existing stock market datasets in scale and diversity while uniquely incorporating sentiment information. Through financial analysis experiments on FNSPID, we propose: (1) the dataset's size and quality significantly boost market prediction accuracy; (2) adding sentiment scores modestly enhances performance on the transformer-based model; (3) a reproducible procedure that can update the dataset. Completed work, code, documentation, and examples are available at github.com/Zdong104/FNSPID. FNSPID offers unprecedented opportunities for the financial research community to advance predictive modeling and analysis.

  • 3 authors
·
Feb 8, 2024

A Deep Neural Network for SSVEP-based Brain-Computer Interfaces

Objective: Target identification in brain-computer interface (BCI) spellers refers to the electroencephalogram (EEG) classification for predicting the target character that the subject intends to spell. When the visual stimulus of each character is tagged with a distinct frequency, the EEG records steady-state visually evoked potentials (SSVEP) whose spectrum is dominated by the harmonics of the target frequency. In this setting, we address the target identification and propose a novel deep neural network (DNN) architecture. Method: The proposed DNN processes the multi-channel SSVEP with convolutions across the sub-bands of harmonics, channels, time, and classifies at the fully connected layer. We test with two publicly available large scale (the benchmark and BETA) datasets consisting of in total 105 subjects with 40 characters. Our first stage training learns a global model by exploiting the statistical commonalities among all subjects, and the second stage fine tunes to each subject separately by exploiting the individualities. Results: Our DNN achieves impressive information transfer rates (ITRs) on both datasets, 265.23 bits/min and 196.59 bits/min, respectively, with only 0.4 seconds of stimulation. The code is available for reproducibility at https://github.com/osmanberke/Deep-SSVEP-BCI. Conclusion: The presented DNN strongly outperforms the state-of-the-art techniques as our accuracy and ITR rates are the highest ever reported performance results on these datasets. Significance: Due to its unprecedentedly high speller ITRs and flawless applicability to general SSVEP systems, our technique has great potential in various biomedical engineering settings of BCIs such as communication, rehabilitation and control.

  • 3 authors
·
Nov 17, 2020

On the Insecurity of Keystroke-Based AI Authorship Detection: Timing-Forgery Attacks Against Motor-Signal Verification

Recent proposals advocate using keystroke timing signals, specifically the coefficient of variation (δ) of inter-keystroke intervals, to distinguish human-composed text from AI-generated content. We demonstrate that this class of defenses is insecure against two practical attack classes: the copy-type attack, in which a human transcribes LLM-generated text producing authentic motor signals, and timing-forgery attacks, in which automated agents sample inter-keystroke intervals from empirical human distributions. Using 13,000 sessions from the SBU corpus and three timing-forgery variants (histogram sampling, statistical impersonation, and generative LSTM), we show all attacks achieve ge99.8% evasion rates against five classifiers. While detectors achieve AUC=1.000 against fully-automated injection, they classify ge99.8% of attack samples as human with mean confidence ge0.993. We formalize a non-identifiability result: when the detector observes only timing, the mutual information between features and content provenance is zero for copy-type attacks. Although composition and transcription produce statistically distinguishable motor patterns (Cohen's d=1.28), both yield δ values 2-4x above detection thresholds, rendering the distinction security-irrelevant. These systems confirm a human operated the keyboard, but not whether that human originated the text. Securing provenance requires architectures that bind the writing process to semantic content.

  • 1 authors
·
Jan 23

Diffeomorphic Mesh Deformation via Efficient Optimal Transport for Cortical Surface Reconstruction

Mesh deformation plays a pivotal role in many 3D vision tasks including dynamic simulations, rendering, and reconstruction. However, defining an efficient discrepancy between predicted and target meshes remains an open problem. A prevalent approach in current deep learning is the set-based approach which measures the discrepancy between two surfaces by comparing two randomly sampled point-clouds from the two meshes with Chamfer pseudo-distance. Nevertheless, the set-based approach still has limitations such as lacking a theoretical guarantee for choosing the number of points in sampled point-clouds, and the pseudo-metricity and the quadratic complexity of the Chamfer divergence. To address these issues, we propose a novel metric for learning mesh deformation. The metric is defined by sliced Wasserstein distance on meshes represented as probability measures that generalize the set-based approach. By leveraging probability measure space, we gain flexibility in encoding meshes using diverse forms of probability measures, such as continuous, empirical, and discrete measures via varifold representation. After having encoded probability measures, we can compare meshes by using the sliced Wasserstein distance which is an effective optimal transport distance with linear computational complexity and can provide a fast statistical rate for approximating the surface of meshes. To the end, we employ a neural ordinary differential equation (ODE) to deform the input surface into the target shape by modeling the trajectories of the points on the surface. Our experiments on cortical surface reconstruction demonstrate that our approach surpasses other competing methods in multiple datasets and metrics.

  • 6 authors
·
May 27, 2023

Usage Bibliometrics as a Tool to Measure Research Activity

Measures for research activity and impact have become an integral ingredient in the assessment of a wide range of entities (individual researchers, organizations, instruments, regions, disciplines). Traditional bibliometric indicators, like publication and citation based indicators, provide an essential part of this picture, but cannot describe the complete picture. Since reading scholarly publications is an essential part of the research life cycle, it is only natural to introduce measures for this activity in attempts to quantify the efficiency, productivity and impact of an entity. Citations and reads are significantly different signals, so taken together, they provide a more complete picture of research activity. Most scholarly publications are now accessed online, making the study of reads and their patterns possible. Click-stream logs allow us to follow information access by the entire research community, real-time. Publication and citation datasets just reflect activity by authors. In addition, download statistics will help us identify publications with significant impact, but which do not attract many citations. Click-stream signals are arguably more complex than, say, citation signals. For one, they are a superposition of different classes of readers. Systematic downloads by crawlers also contaminate the signal, as does browsing behavior. We discuss the complexities associated with clickstream data and how, with proper filtering, statistically significant relations and conclusions can be inferred from download statistics. We describe how download statistics can be used to describe research activity at different levels of aggregation, ranging from organizations to countries. These statistics show a correlation with socio-economic indicators. A comparison will be made with traditional bibliometric indicators. We will argue that astronomy is representative of more general trends.

  • 2 authors
·
Jun 7, 2017

Faster Rates of Convergence to Stationary Points in Differentially Private Optimization

We study the problem of approximating stationary points of Lipschitz and smooth functions under (varepsilon,delta)-differential privacy (DP) in both the finite-sum and stochastic settings. A point w is called an alpha-stationary point of a function F:R^drightarrowR if |nabla F(w)|leq alpha. We provide a new efficient algorithm that finds an Obig(big[sqrt{d}{nvarepsilon}big]^{2/3}big)-stationary point in the finite-sum setting, where n is the number of samples. This improves on the previous best rate of Obig(big[sqrt{d}{nvarepsilon}big]^{1/2}big). We also give a new construction that improves over the existing rates in the stochastic optimization setting, where the goal is to find approximate stationary points of the population risk. Our construction finds a Obig(1{n^{1/3}} + big[sqrt{d}{nvarepsilon}big]^{1/2}big)-stationary point of the population risk in time linear in n. Furthermore, under the additional assumption of convexity, we completely characterize the sample complexity of finding stationary points of the population risk (up to polylog factors) and show that the optimal rate on population stationarity is tilde Thetabig(1{n}+sqrt{d}{nvarepsilon}big). Finally, we show that our methods can be used to provide dimension-independent rates of Obig(1{n}+minbig(big[sqrt{rank}{nvarepsilon}big]^{2/3},1{(nvarepsilon)^{2/5}}big)big) on population stationarity for Generalized Linear Models (GLM), where rank is the rank of the design matrix, which improves upon the previous best known rate.

  • 6 authors
·
Jun 1, 2022

Compound Estimation for Binomials

Many applications involve estimating the mean of multiple binomial outcomes as a common problem -- assessing intergenerational mobility of census tracts, estimating prevalence of infectious diseases across countries, and measuring click-through rates for different demographic groups. The most standard approach is to report the plain average of each outcome. Despite simplicity, the estimates are noisy when the sample sizes or mean parameters are small. In contrast, the Empirical Bayes (EB) methods are able to boost the average accuracy by borrowing information across tasks. Nevertheless, the EB methods require a Bayesian model where the parameters are sampled from a prior distribution which, unlike the commonly-studied Gaussian case, is unidentified due to discreteness of binomial measurements. Even if the prior distribution is known, the computation is difficult when the sample sizes are heterogeneous as there is no simple joint conjugate prior for the sample size and mean parameter. In this paper, we consider the compound decision framework which treats the sample size and mean parameters as fixed quantities. We develop an approximate Stein's Unbiased Risk Estimator (SURE) for the average mean squared error given any class of estimators. For a class of machine learning-assisted linear shrinkage estimators, we establish asymptotic optimality, regret bounds, and valid inference. Unlike existing work, we work with the binomials directly without resorting to Gaussian approximations. This allows us to work with small sample sizes and/or mean parameters in both one-sample and two-sample settings. We demonstrate our approach using three datasets on firm discrimination, education outcomes, and innovation rates.

  • 2 authors
·
Dec 30, 2025

Empirical Risk Minimization under Random Censorship: Theory and Practice

We consider the classic supervised learning problem, where a continuous non-negative random label Y (i.e. a random duration) is to be predicted based upon observing a random vector X valued in R^d with dgeq 1 by means of a regression rule with minimum least square error. In various applications, ranging from industrial quality control to public health through credit risk analysis for instance, training observations can be right censored, meaning that, rather than on independent copies of (X,Y), statistical learning relies on a collection of ngeq 1 independent realizations of the triplet (X, ; min{Y,; C},; δ), where C is a nonnegative r.v. with unknown distribution, modeling censorship and δ=I{Yleq C} indicates whether the duration is right censored or not. As ignoring censorship in the risk computation may clearly lead to a severe underestimation of the target duration and jeopardize prediction, we propose to consider a plug-in estimate of the true risk based on a Kaplan-Meier estimator of the conditional survival function of the censorship C given X, referred to as Kaplan-Meier risk, in order to perform empirical risk minimization. It is established, under mild conditions, that the learning rate of minimizers of this biased/weighted empirical risk functional is of order O_{P}(log(n)/n) when ignoring model bias issues inherent to plug-in estimation, as can be attained in absence of censorship. Beyond theoretical results, numerical experiments are presented in order to illustrate the relevance of the approach developed.

  • 3 authors
·
Jun 5, 2019

A study of a deterministic model for meningitis epidemic

A compartmental deterministic model that allows (1) immunity from two stages of infection and carriage, and (2) disease induced death, is used in studying the dynamics of meningitis epidemic process in a closed population. It allows for difference in the transmission rate of infection to a susceptible by a carrier and an infective. It is generalized to allow a proportion ({\phi}) of those susceptibles infected to progress directly to infectives in stage I. Both models are used in this study. The threshold conditions for the spread of carrier and infectives in stage I are derived for the two models. Sensitivity analysis is performed on the reproductive number derived from the next generation matrix. The case-carrier ratio profile for various parameters and threshold values are shown. So also are the graphs of the total number ever infected as influenced by {\epsilon} and {\phi}. The infection transmission rate (eta), the odds in favor of a carrier, over an infective, in transmitting an infection to a susceptible ({\epsilon}) and the carrier conversion rate ({\phi}) to an infective in stage I, are identified as key parameters that should be subject of attention for any control intervention strategy. The case-carrier ratio profiles provide evidence of a critical case-carrier ratio attained before the number of reported cases grows to an epidemic level. They also provide visual evidence of epidemiological context, in this case, epidemic incidence (in later part of dry season) and endemic incidence (during rainy season). Results from total proportion ever infected suggest that the model, in which {\phi}=0 obtained, can adequately represent, in essence, the generalized model for this study.

  • 2 authors
·
Mar 31, 2023

Preserving Statistical Validity in Adaptive Data Analysis

A great deal of effort has been devoted to reducing the risk of spurious scientific discoveries, from the use of sophisticated validation techniques, to deep statistical methods for controlling the false discovery rate in multiple hypothesis testing. However, there is a fundamental disconnect between the theoretical results and the practice of data analysis: the theory of statistical inference assumes a fixed collection of hypotheses to be tested, or learning algorithms to be applied, selected non-adaptively before the data are gathered, whereas in practice data is shared and reused with hypotheses and new analyses being generated on the basis of data exploration and the outcomes of previous analyses. In this work we initiate a principled study of how to guarantee the validity of statistical inference in adaptive data analysis. As an instance of this problem, we propose and investigate the question of estimating the expectations of m adaptively chosen functions on an unknown distribution given n random samples. We show that, surprisingly, there is a way to estimate an exponential in n number of expectations accurately even if the functions are chosen adaptively. This gives an exponential improvement over standard empirical estimators that are limited to a linear number of estimates. Our result follows from a general technique that counter-intuitively involves actively perturbing and coordinating the estimates, using techniques developed for privacy preservation. We give additional applications of this technique to our question.

  • 6 authors
·
Nov 10, 2014

Environmental Drivers of Respiratory Disease: A District Level Analysis

Sri Lanka has experienced a decade of progressive forest degradation and rising atmospheric pollution, yet district-level respiratory admissions have paradoxically declined, pointing to the confounding role of healthcare access. This study addresses that gap by constructing an 11-year (2014-2024) panel dataset across all 25 administrative districts, integrating satellite-derived vegetation indices, fire radiative power, pollutant concentrations (particulate matter (PM2.5), nitrogen dioxide (NO2), sulfur dioxide (SO2)), carbon flux metrics and population-normalized respiratory admission rates. Two temporally validated XGBoost models were created for annual district-level respiratory rate (R^2 = 0.937) and monthly PM2.5 concentration (R^2 = 0.976) with generalization validated in 21 out of 25 districts (Mean Absolute Percentage Error (MAPE) <= 20%). Shapley Additive Explanations (SHAP) analysis established that cumulative air quality burden is the overwhelming driver of respiratory rate variance (80.1%), ahead of forest degradation (15.6%) and fire activity (4.3%). The Forest-Air-Health (FAH) Risk Index used these SHAP-derived weights to find the districts with the highest risk: Colombo (FAH = 0.802), Gampaha (0.708), and Kalutara (0.682). These findings present the inaugural evidence-based, district-level framework correlating environmental degradation with respiratory health in Sri Lanka, establishing a quantitative basis for focused public health and environmental policy.

  • 9 authors
·
Jul 4

The Autocorrelation Blind Spot: Why 42% of Turn-Level Findings in LLM Conversation Analysis May Be Spurious

Turn-level metrics are widely used to evaluate properties of multi-turn human-LLM conversations, from safety and sycophancy to dialogue quality. However, consecutive turns within a conversation are not statistically independent -- a fact that virtually all current evaluation pipelines fail to correct for in their statistical inference. We systematically characterize the autocorrelation structure of 66 turn-level metrics across 202 multi-turn conversations (11,639 turn pairs, 5 German-speaking users, 4 LLM platforms) and demonstrate that naive pooled analysis produces severely inflated significance estimates: 42% of associations that appear significant under standard pooled testing fail to survive cluster-robust correction. The inflation varies substantially across categories rather than scaling linearly with autocorrelation: three memoryless families (embedding velocity, directional, differential) aggregate to 14%, while the seven non-memoryless families (thermo-cycle, frame distance, lexical/structural, rolling windows, cumulative, interaction, timestamp) aggregate to 33%, with individual category rates ranging from 0% to 100% depending on per-family effect size. We present a two-stage correction framework combining Chelton (1983) effective degrees of freedom with conversation-level block bootstrap, and validate it on a pre-registered hold-out split where cluster-robust metrics replicate at 57% versus 30% for pooled-only metrics. We provide concrete design principles, a publication checklist, and open-source code for the correction pipeline. A survey of ~30 recent papers at major NLP and AI venues that compute turn-level statistics in LLM evaluations finds that only 4 address temporal dependence at all, and 26 do not correct for it.

  • 1 authors
·
Apr 14

Skill-Targeted Adaptive Training

Language models often show little to no improvement (i.e., "saturation") when trained via vanilla supervised fine-tuning (SFT) on data similar to what they saw in their training set (e.g., MATH). We introduce a new fine-tuning strategy, STAT, to train such a student model by using the metacognition ability of a stronger large language model (LLM) as the teacher. The teacher uses the task dataset to create a list of skills needed for the task, and then labels each data point with its required skills (Didolkar et al., 2024). By monitoring the student's answers, the teacher creates a Missing-Skill-Profile for the student, tracking how often they failed to apply each skill in their responses. We use this idea to build a modified training set in one of two ways. In STAT-Sel, the teacher uses an existing set of training examples but adaptively reweights them according to the Missing-Skill-Profile. In STAT-Syn, the teacher synthesizes additional examples involving missing skills. Across extensive experiments on Llama and Qwen models, our methods yield improvements of up to 7.5% on MATH, whereas SFT provides only limited gains. Furthermore, STAT enhances performance on out-of-distribution benchmarks (e.g., AIME24/25, AMC23, etc.) by an average of 4.6%. Crucially, we find that STAT is complementary to RL via GRPO (Shao et al., 2024): after the model is improved using STAT to address skill gaps, GRPO continues to add further gains. We conclude that skill-targeted adaptive training should broadly improve current training pipelines. Our code is available at: https://github.com/princeton-pli/STAT.

PrincetonUniversity Princeton University
·
Oct 11, 2025 2

The strength of clinical evidence is recoverable from language model representations but not from their stated grades

Large language models (LLMs) increasingly summarize clinical evidence, where a claim's weight depends on how strongly it is supported. Yet these models convey confidence poorly, and properties they never state, such as truth, are often readable from their activations. Whether a clinical model registers evidence strength, distinct from truth, and states it when asked is untested, and any such signal could be lexical. We compiled 45,134 clinical claims from six public sources, harmonized 20,611 into a four-level evidence grade under three independent frameworks, and tested 22 local, open-weight LLMs from several developers (0.6-70 billion parameters; general, medical, and reasoning), with lexical, truth, and cross-framework controls. A linear estimator recovered the grade in every model (median AUROC 71.8), yet decodability did not rise with scale and was weakest in reasoning models. The grade the models stated fell to chance, 25-27 percentage points below the estimator. The recoverable signal was largely lexical and did not transfer across topics or frameworks, yet it was distinct from factual truth and still flagged weakly supported claims (AUROC 69.2). Clinical LLMs thus carry an ordered evidence-strength signal they do not express, so their stated grades fail to convey a claim's support even when it is recoverable from their representations and text.

  • 1 authors
·
Jun 26

Bayesian aggregation of average data: An application in drug development

Throughout the different phases of a drug development program, randomized trials are used to establish the tolerability, safety, and efficacy of a candidate drug. At each stage one aims to optimize the design of future studies by extrapolation from the available evidence at the time. This includes collected trial data and relevant external data. However, relevant external data are typically available as averages only, for example from trials on alternative treatments reported in the literature. Here we report on such an example from a drug development for wet age-related macular degeneration. This disease is the leading cause of severe vision loss in the elderly. While current treatment options are efficacious, they are also a substantial burden for the patient. Hence, new treatments are under development which need to be compared against existing treatments. The general statistical problem this leads to is meta-analysis, which addresses the question of how we can combine datasets collected under different conditions. Bayesian methods have long been used to achieve partial pooling. Here we consider the challenge when the model of interest is complex (hierarchical and nonlinear) and one dataset is given as raw data while the second dataset is given as averages only. In such a situation, common meta-analytic methods can only be applied when the model is sufficiently simple for analytic approaches. When the model is too complex, for example nonlinear, an analytic approach is not possible. We provide a Bayesian solution by using simulation to approximately reconstruct the likelihood of the external summary and allowing the parameters in the model to vary under the different conditions. We first evaluate our approach using fake-data simulations and then report results for the drug development program that motivated this research.

  • 6 authors
·
May 12, 2020

Are Large Language Models Good Statisticians?

Large Language Models (LLMs) have demonstrated impressive capabilities across a range of scientific tasks including mathematics, physics, and chemistry. Despite their successes, the effectiveness of LLMs in handling complex statistical tasks remains systematically under-explored. To bridge this gap, we introduce StatQA, a new benchmark designed for statistical analysis tasks. StatQA comprises 11,623 examples tailored to evaluate LLMs' proficiency in specialized statistical tasks and their applicability assessment capabilities, particularly for hypothesis testing methods. We systematically experiment with representative LLMs using various prompting strategies and show that even state-of-the-art models such as GPT-4o achieve a best performance of only 64.83%, indicating significant room for improvement. Notably, while open-source LLMs (e.g. LLaMA-3) show limited capability, those fine-tuned ones exhibit marked improvements, outperforming all in-context learning-based methods (e.g. GPT-4o). Moreover, our comparative human experiments highlight a striking contrast in error types between LLMs and humans: LLMs primarily make applicability errors, whereas humans mostly make statistical task confusion errors. This divergence highlights distinct areas of proficiency and deficiency, suggesting that combining LLM and human expertise could lead to complementary strengths, inviting further investigation into their collaborative potential.

  • 5 authors
·
Jun 11, 2024

Search for dark matter subhalos among unassociated Fermi-LAT sources in presence of dataset shift

We search for dark matter (DM) annihilating subhalos of the Milky Way halo among the Fermi Large Area Telescope (LAT) unassociated sources. We construct, for the first time, a statistical model of the unassociated sources at latitudes above 10 degrees. The latter is built as a combination of both DM annihilation subhalos as well as Galactic and extragalactic astrophysical components. The astrophysical components are constructed based on distributions of associated sources, while the distribution of DM subhalos is derived from Monte Carlo simulations. In this model we take into account the differences in the distributions of associated and unassociated sources including both covariate and prior probability shifts (both being forms of ``dataset shifts''). Previous searches of DM subhalos were based on classify-and-count strategies, while the approach adopted in this work is based on quantification learning, which allows one to determine a well-defined statistical interpretation of the contribution of a population of DM subhalos to the unassociated Fermi-LAT sources. In the bb annihilation channel and for a range of DM masses from 10 GeV to 1 TeV, we don't find a significant contribution from DM subhalos and derive a statistical 95% confidence upper limit on the DM annihilation cross section in this channel. While the derived limits are consistent with previous classify-and-count approaches, our generative statistical model opens new avenues for population studies of Fermi-LAT sources and, more generally, for searches of anomalies on top of backgrounds in presence of statistical and systematic uncertainties.

  • 5 authors
·
Mar 18, 2025

Brewing Discontent: How U.S. Reciprocal Tariffs on Coffee Could Echo the Boston Tea Party

This research employs quantitative techniques interpreted through relevant economic theories to analyze a proposed U.S. "Discounted Reciprocal Tariff" structure. Statistical modeling (linear regression) quantifies the policy's consistent 'discounted reciprocity' pattern, which is interpreted using a Game Theory perspective on strategic interaction. Machine learning (K-Means clustering) identifies distinct country typologies based on tariff exposure and Economic Complexity Index (ECI), linking the policy to Economic Complexity theory. The study's primary application focuses on the major coffee exporting sector, utilizing simulation modeling grounded in principles of demand elasticity and substitution to project potential trade flow impacts. Specifically, for coffee, this simulation demonstrates how the proposed tariff differentials can induce significant substitution effects, projecting a potential shift in U.S. import demand away from high-tariff origins toward lower-tariff competitors. This disruption, stemming from the tariffs impacting exporting countries, is projected to ultimately increase coffee prices for consumers in the United States. Findings throughout are contextualized within Political Economy considerations. Overall, the study demonstrates how integrating regression, clustering, and simulation with economic theory exemplified through the coffee sector analysis provides a robust framework for assessing the potential systemic impacts, including consumer price effects, of strategic trade policies.

  • 1 authors
·
Apr 2, 2025