Sync cpgptpcgrimage3
Browse files- README.md +38 -0
- config.json +37 -0
- cpgptpcgrimage3.pt +3 -0
README.md
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---
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license: bsd-3-clause
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library_name: pyaging
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tags:
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- pyaging
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- aging-clock
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- biology
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- dna-methylation
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---
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# cpgptpcgrimage3
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Principal-component CpGPTGrimAge3 implementation combining chronological age, GrimAge2 DNAm proxies, and CpGPT-predicted plasma-protein proxies; 30 proxy inputs are projected to 29 PCs, entered with age into a Cox linear predictor, and calibrated to years.
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| | |
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|---|---|
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| **Predicts** | biological age, mortality risk |
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| **Species** | Homo sapiens |
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| **Tissue** | whole blood |
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| **Data type** | DNA methylation |
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| **Model type** | PCA + Cox regression |
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| **Year** | 2024 |
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## Use with pyaging
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```python
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import pyaging as pya
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pya.pred.predict_age(adata, ["cpgptpcgrimage3"])
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```
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Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io).
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## Citation
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de Lima Camillo, L. P., Sehgal, R., Armstrong, J., Higgins-Chen, A. T., Horvath, S., & Wang, B. CpGPT: a foundation model for DNA methylation. bioRxiv 2024.10.24.619766 (2024).
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https://doi.org/10.1101/2024.10.24.619766
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config.json
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{
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"approved_by_author": "\u2705",
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"citation": "de Lima Camillo, L. P., Sehgal, R., Armstrong, J., Higgins-Chen, A. T., Horvath, S., & Wang, B. CpGPT: a foundation model for DNA methylation. bioRxiv 2024.10.24.619766 (2024).",
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"citations": 30,
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"citations_date": "2026-07-05",
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"clock_name": "cpgptpcgrimage3",
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"data_type": "DNA methylation",
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"doi": "https://doi.org/10.1101/2024.10.24.619766",
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"journal": "bioRxiv",
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"last_author": "Bo Wang",
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"model_type": "PCA + Cox regression",
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"n_features": 31,
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"notes": "Principal-component CpGPTGrimAge3 implementation combining chronological age, GrimAge2 DNAm proxies, and CpGPT-predicted plasma-protein proxies; 30 proxy inputs are projected to 29 PCs, entered with age into a Cox linear predictor, and calibrated to years.",
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"platform": [
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"Illumina 450K"
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],
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"population": "adults",
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"postprocess": "cox_to_years",
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"predicts": [
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"biological age",
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"mortality risk"
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],
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"preprocess": "scale",
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"research_only": true,
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"species": "Homo sapiens",
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"tissue": [
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"whole blood"
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],
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"training_target": [
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"mortality"
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],
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"unit": [
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"years"
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],
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"version": "v0.3.0",
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"year": 2024
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}
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cpgptpcgrimage3.pt
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version https://git-lfs.github.com/spec/v1
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oid sha256:7bef61dfe7170ac49f50009a28a46995ead58e88b7f6591f9e84eb5c27ac51ad
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size 14625
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