| { |
| "approved_by_author": "\u231b", |
| "citation": "Goeminne, L. J. E., et al. \"Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems.\" Cell Metabolism 37, 205\u2013222.e6 (2025).", |
| "citations": 128, |
| "citations_date": "2026-10-02", |
| "clock_name": "organagemortalitybrain", |
| "data_type": "proteomics", |
| "doi": "https://doi.org/10.1016/j.cmet.2024.10.005", |
| "journal": "Cell Metabolism", |
| "last_author": "Vadim N. Gladyshev", |
| "model_type": "elastic net Cox regression", |
| "n_features": 118, |
| "notes": "Brain OrganAge mortality model for Olink Explore 3072, using author-recommended fold 1. Trained on UK Biobank plasma measured with Olink Explore 3072. Input columns are original case-sensitive protein symbols (e.g. NTproBNP, HLA-DRA), not UniProt IDs or Olink assay IDs. Values are assay-normalized Olink NPX on the log2 relative-abundance scale, not raw counts, concentrations, linear abundances or z-scores. No additional centering or cohort scaling is applied. Absent proteins contribute zero; NaNs in supplied proteins propagate, matching the original Example_Script.R scoring expressions. For other assays, the authors recommend a symmetric abundance distribution, protein-wise mean subtraction and SD division, then multiplication by the full-model UKB protein SDs in Table S3. This cohort-dependent cross-platform preparation is not performed by pyaging. The optional Example_Script.R SD-matching step is also external; NPX labeling alone does not establish comparability across Olink panels, batches, plasma and serum. Output is relative natural-log mortality hazard, not age in years. The 2026 Insilico trial used conventional OrganAge models on Olink Explore 3072 serum; organ-specific variants are not the six-clock comparison endpoints. pyaging returns the original raw score and does not apply the trial wrapper's cohort harmonization or mortality-to-years conversion. Models labelled Female and Male contain protein features; neither requires a sex covariate. Academic/non-commercial research use only; commercial use requires a separate license from the authors.", |
| "platform": [ |
| "Olink Explore 3072" |
| ], |
| "population": "adults", |
| "predicts": [ |
| "mortality risk" |
| ], |
| "reference_values": true, |
| "research_only": true, |
| "species": "Homo sapiens", |
| "tissue": [ |
| "plasma" |
| ], |
| "training_target": [ |
| "mortality" |
| ], |
| "unit": [ |
| "log hazard" |
| ], |
| "version": "0.5.5", |
| "year": 2025 |
| } |
