| { |
| "approved_by_author": "\u231b", |
| "citation": "Endicott, J.L., Nolte, P.A., Shen, H. & Laird, P.W. Cell division drives DNA methylation loss in late-replicating domains in primary human cells. Nature Communications 13, 6659 (2022).", |
| "citations": 93, |
| "citations_date": "2026-10-02", |
| "clock_name": "replitalinorm", |
| "data_type": "DNA methylation", |
| "doi": "https://doi.org/10.1038/s41467-022-34268-8", |
| "journal": "Nature Communications", |
| "last_author": "Peter W. Laird", |
| "model_type": "elastic net regression", |
| "n_features": 218, |
| "notes": "Upstream starting-PD normalization model used during RepliTali construction. It was trained only in the chronologically youngest fetal skin fibroblast line (AG06561) to estimate the unobserved pre-culture replicative-history offset; it is not the final 87-CpG RepliTali model.", |
| "platform": [ |
| "Illumina EPIC" |
| ], |
| "population": "human cell cultures", |
| "predicts": [ |
| "replicative history" |
| ], |
| "research_only": null, |
| "species": "Homo sapiens", |
| "tissue": [ |
| "cultured fibroblasts" |
| ], |
| "training_target": [ |
| "population doublings" |
| ], |
| "unit": [ |
| "population doublings" |
| ], |
| "version": "0.5.7", |
| "year": 2022 |
| } |
