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library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
---
# systemsagebrain
Brain-system component of Systems Age: a whole-blood DNAm score built from brain-system biomarker and functional PCs and mortality training, returned on an age-like scale.
Model weights retain the original authors' terms; the pyaging software license does not relicense them. These weights are restricted to research use under the authors' terms.
| | |
|---|---|
| **Predicts** | brain-system biological age |
| **Species** | Homo sapiens |
| **Tissue** | whole blood |
| **Data type** | DNA methylation |
| **Model type** | PCA + elastic net regression |
| **Year** | 2025 |
## Use with pyaging
```python
import pyaging as pya
pya.pred.predict_age(adata, ["systemsagebrain"])
```
Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io).
## Citation
Sehgal, R., Markov, Y., Qin, C., et al. (2025). Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems. Nature Aging, 5, 1880–1896.
https://doi.org/10.1038/s43587-025-00958-3
|