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"approved_by_author": "\u231b",
"citation": "Sehgal, R., Markov, Y., Qin, C., et al. (2025). Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems. Nature Aging, 5, 1880\u20131896.",
"citations": 57,
"citations_date": "2026-10-02",
"clock_name": "systemsagebrain",
"data_type": "DNA methylation",
"doi": "https://doi.org/10.1038/s43587-025-00958-3",
"journal": "Nature Aging",
"last_author": "Morgan Levine",
"model_type": "PCA + elastic net regression",
"n_features": 125175,
"notes": "Brain-system component of Systems Age: a whole-blood DNAm score built from brain-system biomarker and functional PCs and mortality training, returned on an age-like scale.",
"platform": [
"Illumina 450K",
"Illumina EPIC"
],
"population": "older adults",
"predicts": [
"brain-system biological age"
],
"reference_values": true,
"research_only": true,
"species": "Homo sapiens",
"tissue": [
"whole blood"
],
"training_target": [
"mortality"
],
"unit": [
"years"
],
"version": "0.5.7",
"year": 2025
} |