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"approved_by_author": "\u231b",
"citation": "Zhang, Y., Wilson, R., Heiss, J. et al. DNA methylation signatures in peripheral blood strongly predict all-cause mortality. Nature Communications 8, 14617 (2017).",
"citations": 421,
"citations_date": "2026-10-02",
"clock_name": "zhangmortality",
"data_type": "DNA methylation",
"doi": "https://doi.org/10.1038/ncomms14617",
"journal": "Nature Communications",
"last_author": "Hermann Brenner",
"model_type": "weighted linear score",
"n_features": 10,
"notes": "Ten-CpG whole-blood mortality risk score. Pyaging implements the paper supplement's continuous LASSO-weighted score exactly (the sum of ten raw beta values multiplied by their published coefficients). The same study also defines a separate simplified 0-10 aberrant-methylation count based on cohort-specific quartile cutoffs.",
"platform": [
"Illumina 450K"
],
"population": "older adults",
"predicts": [
"mortality risk"
],
"research_only": null,
"species": "Homo sapiens",
"tissue": [
"whole blood"
],
"training_target": [
"mortality"
],
"unit": [
"unitless"
],
"version": "0.5.7",
"year": 2017
} |