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| <body> | |
| <h1>RefLab</h1> | |
| <div class="kicker">Tietz 7e · Appendix A · Tables A.1–A.5 · <span id="counts"></span></div> | |
| <div class="tabs"> | |
| <button class="tab on" data-tab="check">RefCheck <span class="meta">flag a result</span></button> | |
| <button class="tab" data-tab="surf">RefSurf <span class="meta">browse an analyte</span></button> | |
| <button class="tab" data-tab="crit">Critical <span class="meta">risk thresholds</span></button> | |
| </div> | |
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| <div id="pane-crit" class="pane hide"></div> | |
| <footer> | |
| Reference intervals are method- and population-dependent. Tietz states these values are for general information only; every laboratory establishes or verifies its own intervals (CLSI EP28-A3c/C28-A3) before clinical use. Biological-variation specifications come from the Ricos et al. database (2014 update) hosted by Westgard QC, and are shown only for analytes present in it. Values here are parsed from the printed appendix tables — spot-check against the source before quoting. Not a diagnostic device. | |
| </footer> | |
| <script> | |
| const DB = {"a":[["11-Deoxycortisol",["Pediatric values based on","LCMS/MS"],[["S","","nmol/L","0.0289",[["Cord blood","295–554","9–16","1"],["Child and adult","20–158","0.6–4.6",""],["0–<1 y","0.00–183","0.00–5.30","16"],["1–<2 y","3.46–30.4","0.10–0.88",""],["2–<7 y","2.42–37.0","0.07–1.07",""],["7–<12 y","3.11–78.5","0.09–2.27",""],["12–<19 y","0.00–78.9","0.00–2.28",""]],"p. 1406"]],"A1","p. 1406",85],["17-Hydroxyprogesterone",["Values (4 d–<19 y) based","on Abbott Architect","method","Tanner values based on","Abbott Architect method","For LC-MSMS reference"],[["","ng/dL","nmol/L","0.03",[["Cord blood","900–5000","27.3–151.5","1"],["Premature","26–568","0.8–17.0",""],["4 d–<1 y","<130","<4.2","15"],["1–<10 y","<35","<1.1",""],["10–<15 y","13–90","0.4–2.7",""],["15–<19 y, F","20–1030","0.6–32.6",""],["15–<19 y, M","20–60","0.5–1.8",""],["Pubertal levels","","",""],["Tanner stage","","",""],["1, M","<44","<1.4",""],["1, F","<28","<0.9",""],["2, M","<44","<1.4",""],["2, F","13–41","0.4–1.3",""],["3, M","<50","<1.6",""],["3, F","16–47","0.5–1.5",""],["4, M","<41","<1.3",""],["4, F","19–72","0.6–2.3",""],["5, M","13–50","0.4–1.6",""],["5, F","<1028","<34.4",""],["Adults","","","1"],["M","27–199","0.8–6.0",""],["F","","",""],["Follicular phase","15–70","0.4–2.1",""],["Luteal phase","35–290","1.0–8.7",""],["Pregnancy","200–1200","6.0–36.0",""]],"p. 1414"],["","Conventional","nmol/L","Conversion",[["Post ACTH","<320","<9.6",""],["Postmenopausal","<70","<2.1",""]],"p. 1415"]],"A1","pp. 1414–1415",130,{"sp":"S","nm":"17-Hydroxyprogesterone","n":"2","cvi":19.6,"cvg":50.4}],["2-Hydroxyglutaric acid",["5-Hydroxyindoleacetic acid"],[["U","","mmol/mol creatinine","",[["","","<16","1"],["*See Chapter 53","","",""],["Table 53.14","","",""]],"p. 1414"]],"A1","p. 1414",127],["2-Methylbutyrylglycine",[],[["U","","mmol/mol creatinine","",[["","","0.2–5","1"]],"p. 1421"]],"A1","p. 1421",166],["2-Oxoglutaric acid",[],[["S","","mmol/mol creatinine","",[["0–1 mo","","22–567","1"],["1–6 mo","","63–552",""],["6 mo–5 y","","36–103",""],[">5 y","","41–82",""]],"p. 1422"]],"A1","p. 1422",178],["21-Hydroxyprogesterone",["Pediatric values based on","LC-MS/MS method"],[["S","nmol/L","nmol/L","1",[["0–<1 y","0.07–0.76","0.07–0.76","16"],["1–<2 y","0.03–-0.25","0.03–-0.25",""],["2–<12 y","0.00–0.15","0.00–0.15",""],["12–<19 y","0.00–0.24","0.00–0.24",""]],"p. 1415"]],"A1","p. 1415",131],["3-Hydroxybutyric acid",[],[["U","","mmol/mol creatinine","",[["0–5 y","","<6","1"],[">5 y","","<11",""]],"p. 1414"]],"A1","p. 1414",126],["3-Phenylpropionylglycine",[],[["U","","mmol/mol creatinine","",[["","","<0.7","1"]],"p. 1424"]],"A1","p. 1424",188],["3α-Androstanediol",["glucuronide"],[["S","ng/dL","nmol/L","0.0213",[["exceed SHBG","","",""],["binding capacity","","",""],["Child, prepubertal 10–60","","0.2–1.3","1"]],"p. 1394"],["","Conversion","Reference","0.0213",[["Adult, M","260–1500","5.5–32",""],["Adult, F","60–300","1.3–6.4",""]],"p. 1395"]],"A1","pp. 1394–1395",19],["4-Hydroxyphenyllactic acid",[],[["U","","mmol/mol creatinine","",[["0–1 mo","","<51","1"],[">1 mo","","<11",""]],"p. 1414"]],"A1","p. 1414",128],["4-Hydroxyphenylpyruvic acid",[],[["U","","mmol/mol creatinine","",[["0–1 mo","","<21","1"],[">1 mo","","<6",""]],"p. 1414"]],"A1","p. 1414",129],["5-Flucytosine (Ancobon)",[],[["S or P","µg/mL","µmol/L","7.75",[["Peak",">25",">194",""],["Toxic",">100",">775",""]],"p. 1453"]],"A3","p. 1453",42],["Acetaldehyde",[],[["WB (F−/Ox)","mg/dL","µmol/L","22.7",[["","<0.2","<4.5","1"],["Occup exp","<0.5","<11.4",""],["Toxic","1–2","22.7–45.4",""]],"p. 1392"]],"A1","p. 1392",1],["Acetaminophen (Tylenol)",[],[["S or P","µg/mL","µmol/L","6.62",[["Therap","10–30","66–199",""],["Toxic","","",""],["4 h after dose",">200",">1324",""],["12 h after dose",">50",">331",""]],"p. 1450"]],"A3","p. 1450",1],["Acetylaspartic acid",[],[["U","","mmol/mol creatinine","",[["","","<14","1"]],"p. 1392"]],"A1","p. 1392",2],["Adipic acid",[],[["U","","mmol/mol creatinine","",[["0–6 mo","","9–37","1"],["6 mo–5 y","","<16",""],[">5 y","","<6",""]],"p. 1392"]],"A1","p. 1392",5],["Adipocarnitine",[],[["U","","mmol/mol creatinine","",[["0–7 d","","0.04–0.40","1"],["8 d–7 y","","0.01–0.81",""],[">7 y","","0.00–0.13",""]],"p. 1392"]],"A1","p. 1392",6],["Adrenocorticotropic hormone (ACTH)",["ACTH reference intervals","may vary depending on","immunoassay methods"],[["P, EDTA","pg/mL","pmol/L","0.22",[["Cord","50–570","11–125","1"],["Newborn","10–185","2.2–41",""],["Adult (0800– 0900 h)","<120","<26",""],["Adult (24 h, supine)","<85","<19",""]],"p. 1392"]],"A1","p. 1392",7],["Alanine",[],[["P","mg/dL","µmol/L","112.2",[["Premature, 1 d","2.44–4.24","274–476","1"],["Newborn, 1 d","2.10–3.65","236–410",""],["1–3 mo","1.19–3.71","134–416",""],["2–6 mo","1.58–3.68","177–413",""],["9 mo–2 y","0.88–2.79","99–313",""],["3–10 y","1.22–2.71","137–305",""],["6–18 y","1.72–4.85","193–545",""],["Adult","1.87–5.88","210–661",""]],"p. 1392"],["S","mg/dL","µmol/L","112.2",[["0–<1 wk","1.56–3.81","175–427","20"],["1 wk–<19 y","1.85–5.24","208–588",""]],"p. 1392"],["U, 24 h","mg/d","µmol/d","11.2",[["10 d–7 wk","4.1–9.3","46–104",""],["3–12 y","9.1–39.2","102–439",""],["Adult","7.9–48.3","88–541",""]],"p. 1392"],["","µmol/g creatinine","µmol/mol creatinine","0.113",[["0–1 mo","554–2957","62.6–334.1",""],["1–6 mo","613–2874","59.3–324.8",""],["6 mo–1 y","428–2064","48.4–233.2",""],["1–2 y","389–1497","44.0–169.2",""],["2–3 y","255–1726","28.8–195.0",""]],"p. 1392"]],"A1","p. 1392",8,{"sp":"P","nm":"Alanine","n":"1","cvi":14.7,"cvg":55.8}],["Alanine aminotransferase",["With pyridoxal phosphate","Values (0–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","OCD Vitros method","Without pyridoxal"],[["S","U/L","µkat/L","0.017",[["0–<1 y","5–51","0.08–0.85","7"],["1–<3 y","11–30","0.18–0.50",""],["3–5 y","15–33","0.26–0.56","27"],["6–8 y","16–37","0.27–0.63",""],["9–11 y","18–39","0.31–0.66",""],["12–17 y, M","17–50","0.29–0.85",""],["12–49 y, F","14–41","0.24–0.70",""],["18–49 y, M","18–78","0.31–1.33",""],["50–79 y, M","20–62","0.34–1.05",""],["50–79 y, F","16–44","0.27–0.75",""],["0–<1 y","5–33","0.08–0.56","7"],["1–<13 y","9–25","0.15–0.43",""],["13–19 y","8–22","0.14–0.37",""]],"p. 1393"]],"A1","p. 1393",9,{"sp":"S","nm":"Alanine aminotransferase (ALT)","n":"9","cvi":19.4,"cvg":41.6}],["Albumin",[],[["CSF, lumbar","mg/dL","mg/L","10",[["","17.7–25.1","177–251",""]],"p. 1449"]],"A2","p. 1449",2],["Albumin (BCG)",["Values (0–<3 y) based on S","Abbott Architect method","Values (3–79 y) based on","OCD Vitros method","Values (3–79 y) based on"],[["S","g/dL","g/L","10",[["0–<15 d","3.3–4.5","33–45","7"],["15 d–<1 y","2.8–4.7","28–47",""],["1–<8 y","3.8–4.7","38–47",""],["8–<15 y","4.1–4.8","41–48",""],["15–<19 y F","4.0–4.9","40–49",""],["15–<19 y M","4.1–5.1","41–51",""],["3–5 y","3.9–5.0","39–50","27"],["6–15 y","4.1–5.1","41–51",""],["16–29 y, M","4.6–5.3","46–53",""],["16–54 y, F","3.9–5.0","39–50",""],["30–54 y, M","4.4–5.1","44–51",""],["55–79 y","4.2–5.0","42–50",""]],"p. 1393"],["CSF, lumbar","g/dL","g/L","10",[["See Table A.2","","","1"],["Adult","","",""],["20–60 y","3.5–5.2","35–52",""],["60–90 y","3.2–4.6","32–46",""],[">90 y","2.9–4.5","29–45",""]],"p. 1393"],["U","mg/L","mg/L","1",[["3–5 y","1.5–21.5","1.5–21.5","28"],["6–8 y","1.5–37.8","1.5–37.8",""],["9–19 y","1.5–169.6","1.5–169.6",""],["20–29 y","1.5–74.6","1.5–74.6",""],["30–39 y","1.5–36.8","1.5–36.8",""],["40–79 y","1.5–47.2","1.5–47.2",""]],"p. 1393"]],"A1","p. 1393",10,{"sp":"S","nm":"Albumin","n":"24","cvi":3.2,"cvg":4.75}],["Albumin-creatinine ratio",["(NKDEP guidelines; see","also Chapter 34)"],[["","mg/mmol","mg/g creatinine","",[["M","<2.5","<22",""],["F","<3.5","<30",""]],"p. 1393"]],"A1","p. 1393",11],["Aldolase",[],[["S","U/L","µkat/L","0.017",[["Child","","","1"],["10–24 mo","10–40","0.17–0.68",""],["25 mo–16 y","5–20","0.09–0.34",""],["Adult","2.5–10.0","0.04–0.13",""]],"p. 1393"]],"A1","p. 1393",12],["Aldosterone",[],[["S","ng/dL","nmol/L","0.0277",[["Cord blood","40–200","1.11–5.54","1"],["Premature infant","19–141","0.53–3.91",""],["Full-term infant","","",""],["3d","7–184","0.19–5.10",""],["1 wk","5–175","0.03–4.85",""],["1–12 mo","5–90","0.14–2.49",""]],"p. 1393"],["","Conventional","nmol/L","Conversion",[["1–2 y","7–54","0.19–1.50",""],["2–10 y (supine)","3–35","0.08–0.97",""],["2–10 y (upright)","5–80","0.14–2.22",""],["10–15 y (supine)","2–22","0.06–0.61",""],["10–15 y (upright)","4–48","0.11–1.33",""],["Adult","","",""],["Supine","3–16","0.08–0.44",""],["Upright","7–30","0.19–0.83",""]],"p. 1394"],["U, 24 h","µg/d","nmol/d","Conversion",[["Newborn (1–3 d)","0.5–5","1–14","1"],["Prepubertal child","","",""],["4–10 y","1–8","3–22",""],["Adult","3–19","8–53",""]],"p. 1394"]],"A1","pp. 1393–1394",13,{"sp":"S","nm":"Aldosterone","n":"2","cvi":29.4,"cvg":40.1}],["Aluminum",[],[["S, P","µg/L","µmol/L","0.0371",[["","<5.51","<0.2","1"],["Patients on","20–550","0.74–20.4",""],["hemodialysis","","",""],["Al medication","<30","<1.11",""]],"p. 1394"],["U","µg/L","µmol/L","0.0371",[["","5–30","0.19–1.11",""]],"p. 1394"]],"A1","p. 1394",14],["Amikacin (Amikin)",[],[["S or P","µg/mL","µmol/L","1.71",[["Therap","","",""],["Peak","25–35","43–60",""],["Trough","","",""],["Less severe infection","1–4","2–7",""],["Severe infection","4–8","7–14",""],["Toxic","","",""],["Peak",">40",">68",""],["Trough",">10",">17",""],["Peak/MIC",">10",">17",""]],"p. 1450"]],"A3","p. 1450",2],["Aminocaproic acid (Amicar)",[],[["S or P","µg/mL","µmol/L","7.62",[["Therap","","",""],["Trough","100–400","762–3048",""]],"p. 1450"]],"A3","p. 1450",3],["Amiodarone (Cordarone)",[],[["S or P","µg/mL","µmol/L","1.47",[["Therap","0.5–2.0","1–3",""],["Toxic",">2.5",">4",""]],"p. 1451"]],"A3","p. 1451",4],["Amitriptyline (Elavil) + nortriptyline",[],[["S or P","ng/mL","nmol/L","3.61",[["Therap","80–200","289–722",""]],"p. 1451"]],"A3","p. 1451",5],["Ammonia nitrogen",[],[["P (Hep)","µg N/dL","µmol N/L","0.714",[["Newborn","90–150","64–107","1"],["0–2 wk","79–129","56–92",""],[">1 mo","29–70","21–50",""],["Adult","15–45","11–32",""]],"p. 1394"],["U, 24 h","mg N/d","mmol N/d","0.0714",[["Infant","560–2900","40–207","1"],["Adult","140–1500","10–107",""]],"p. 1394"]],"A1","p. 1394",15],["Amobarbital (Amytal)",[],[["S or P","µg/mL","µmol/L","4.42",[["Therap","1–5","4–22",""],["Toxic",">10",">44",""]],"p. 1451"]],"A3","p. 1451",6],["Amoxapine (Asendin) + 8-hydroxy amoxapine",[],[["S or P","ng/mL","nmol/L","3 .19",[["Therap","200–600","638–1914",""],["Toxic",">600",">1914",""]],"p. 1451"]],"A3","p. 1451",7],["Amphetamine (Adderall)",[],[["S or P","ng/mL","nmol/L","7.40",[["Therap","20–30","148–222",""],["Toxic",">200",">1480",""]],"p. 1451"]],"A3","p. 1451",8],["Amylase",["Values (0–<19 y) based on","Abbott Architect method","IFCC, 37°C"],[["S","U/L","µkat/L","0.017",[["0–14 d","3–10","0.05–0.17","7"],["15 d–<13 wk","2–22","0.03–0.37",""],["13 wk–<1 y","3–50","0.05–0.83",""],["1–<19 y","25–101","0.42–1.68",""],["Adult","31–107","0.52–1.78","30"]],"p. 1394"]],"A1","p. 1394",16,{"sp":"S","nm":"α-Amylase","n":"7","cvi":8.7,"cvg":28.3}],["Amylase (pancreatic)",["Values (0–<19 y) based on","Abbott Architect method"],[["S","U/L","µkat/L","0.017",[["0–<6 mo","<11.5","<0.20","14"],["6 mo–<1 y","0.62–23.2","0.01–0.39",""],["1–<2 y, F","2.63–27.8","0.04–0.47",""],["1–<2 y, M","0.68–22.5","0.01–0.38",""],["2–<19 y","4.10–31.3","0.07–0.53",""]],"p. 1394"]],"A1","p. 1394",17,{"sp":"S","nm":"α-Amylase","n":"7","cvi":8.7,"cvg":28.3}],["Androgen index, free (FAI)",[],[["S","","%","",[["0–<1 y, F","","0.04–1.32","18"],["1–<9 y, F","","0.04–1.32",""],["9–<14 y, F","","0.12–2.63",""],["14–19 y, F","","0.59–6.50",""],["0–<1 y, M","","0.02–32.72",""],["1–<9 y, M","","0.03–0.60",""],["9–<14 y, M","","0.15–34.68",""],["14–<19 y, M","","3.58–83.30",""]],"p. 1394"],["","be used in men if","levels exceed SHBG","testosterone",[["binding capacity.","","",""]],"p. 1394"]],"A1","p. 1394",18],["Androstenedione (LC-MS/MS)",[],[["S","ng/L","","",[["6–24 mo","25–150","","37"],["2–3 y","<110","",""],["4–5 y","23–170","",""],["6–7 y","10–290","",""],["7–9 y","30–300","",""],["10–11 y","70–390","",""],["12–13 y","100–640","",""],["14–15 y","180–940","",""],["16–17 y","300–1130","",""],["18–40 y","330–1340","",""],["40–67 y","280–890","",""]],"p. 1395"]],"A1","p. 1395",20],["Antimony",[],[["P (Hep)","µg/dL","nmol/L","82.1",[["","0.014–0.090","1.15–7.39","1"]],"p. 1395"],["U","µg/L","nmol/L","8.21",[["","<10","<82.1",""]],"p. 1395"],["","mg/L","µmol/L","8.21",[["Toxic",">1",">8.21",""]],"p. 1395"]],"A1","p. 1395",22],["Antistreptolysin-O (ASO)",["Values (0–<19 y) based on","Abbott Architect method"],[["S","IU/mL","kIU/L","1",[["0–<6 mo","0–0","0–0","7"],["6 mo–<1 y","0–30","0–30",""],["1–<6 y","0–104","0–104",""],["6–<19 y","0–331","0–331",""],["Adult","<20–364","<20–364","32"]],"p. 1395"]],"A1","p. 1395",23],["Antithyroglobulin (Anti-Tg)",["Values based on Abbott","Architect method"],[["S","IU/mL","kIU/L","1",[["0–<19 y","0.4–17.7","0.4–17.7","4"]],"p. 1395"]],"A1","p. 1395",24],["Apolipoprotein Al",["Values (0–<6 y) based on","Abbott Architect method","Values (6–79 y) based on","OCD Vitros method"],[["S","mg/dL","g/L","0.01",[["0–14 d, F","71–97","0.7–1.0","7"],["0–14 d, M","62–91","0.6–0.9",""],["15 d–<1 y","53–175","0.5–1.8",""],["1–<6 y","80–164","0.8–1.6",""],["6–15 y","100–180","1.0–1.8","28"],["16–39 y, M","80–170","0.8–1.7",""],["16–39 y, F","100–200","1.0–2.0",""],["40–79 y, M","120–200","1.2–2.0",""],["40–79 y, F","110–230","1.1–2.3",""]],"p. 1395"]],"A1","p. 1395",26],["Apolipoprotein B-100",["Values (0–<6 y) based on","Abbott Architect method","Values (6–79 y) based on","OCD Vitros method"],[["S","mg/dL","g/L","0.01",[["0–14 d","9–67","0.1–0.7","7"],["15 d–<1 y","19–123","0.2–1.2",""],["1–<6 y","41–93","0.4–0.9",""],["6–13 y","50–100","0.5–1.0","28"],["14–29 y","40–110","0.4–1.1",""],["30–79 y","60–140","0.6–1.4",""]],"p. 1395"]],"A1","p. 1395",27],["Arginine",[],[["P","mg/dL","µmol/L","57.4",[["Premature, 1 d","0.17–1.57","10–90","1"],["Newborn, 1 d","0.38–1.53","22–88",""],["1–3 mo","0.38–1.30","22–74",""],["2–6 mo","0.98–2.47","56–142",""],["9 mo–2 y","0.19–1.13","11–65",""],["3–10 y","0.40–1.50","23–86",""],["6–18 y","0.77–2.26","44–130",""],["Adult","0.37–2.40","21–138",""]],"p. 1396"],["S","mg/dL","µmol/L","57.4",[["0–<1 mo","0.03–2.06","2–118","20"],["1 mo–<1 y","0.82–2.40","47–138",""],["1–<19 y","1.15–2.61","66–150",""]],"p. 1396"],["U, 24 h","mg/d","µmol/d","5.74",[["10 d–7 wk","<1.2","<7","1"],["3–12 y","<5.1","<29",""],["Adult","<50.2","<288",""]],"p. 1396"],["","mg/g creatinine","mmol/mol creatinine","0.65",[["Adult","0–4","0–2.7",""]],"p. 1396"]],"A1","p. 1396",28,{"sp":"P","nm":"Arginine","n":"1","cvi":19.3,"cvg":34.1}],["Arsenic",["Ascorbic acid (see","vitamin C)"],[["WB (Hep)","µg/L","µmol/L","0.0113",[["Not exposed","2–23","0.03–0.31","1"],["Chronic poisoning","100–500","1.33–6.65",""],["Acute poisoning 600–9300","","7.98–124",""],["Not exposed","2–23","0.03–0.31",""]],"p. 1396"]],"A1","p. 1396",29],["Asparagine",[],[["P","mg/dL","µmol/L","75.7",[["1–3 mo","0.08–0.44","6–33","1"],["3 mo–6 y","0.95–1.90","72–144",""],["6–18 y","0.42–0.82","32–62",""],["Adult","0.40–0.91","30–69",""]],"p. 1396"],["S","mg/dL","µmol/L","75.7",[["0–<19 y","0.50–1.20","38–91","20"]],"p. 1396"],["U, 24 h","mg/d","µmol/d","7.57",[["Adult","4.5–13.2","34–100","1"]],"p. 1396"],["","mg/g creatinine","mmol/mol creatinine","0.86",[["Adult","2–10","1.8–8.6",""]],"p. 1396"]],"A1","p. 1396",30,{"sp":"P","nm":"Asparagine","n":"1","cvi":12.3,"cvg":28.0}],["Aspartate aminotransferase",["With pyridoxal phosphate","Values (0–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","OCD Vitros method","Without pyridoxal"],[["S","U/L","µkat/L","0.017",[["0–14 d","23–186","0.38–3.10","7"],["15 d–<1 y","23–83","0.38–1.38",""],["1–<3 y","26–55","0.43–0.92",""],["3–5 y","28–52","0.48–0.88","27"],["6–11 y, M","25–47","0.43–0.80",""],["F","23–44","0.39–0.75",""],["12–17 y, M","18–36","0.31–0.61",""],["12–19 y, F","15–34","0.26–0.58",""],["18–54 y, M","18–54","0.31–0.92",""],["20–54 y, F","18–34","0.31–0.58",""],["55–79 y","18–39","0.31–0.66",""],["0–14 d","32–162","0.54–2.75","7"],["15 d–<1 y","20–67","0.34–1.14",""],["1–<7 y","21–44","0.36–0.75",""],["7–<12 y","18–36","0.31–0.61",""],["12–19 y, M","14–35","0.24–0.60",""],["F","13–26","0.22–0.44",""]],"p. 1396"]],"A1","p. 1396",31,{"sp":"S","nm":"Aspartate aminotransferase (AST)","n":"13","cvi":12.3,"cvg":23.1}],["Aspartic acid",[],[["P","mg/dL","µmol/L","75.1",[["Premature, 1 d","0–0.39","0–30","1"],["Newborn, 1 d","<0.21","<16",""],["1–3 mo","0–0.15","0–8",""],["9 mo–2 y","<0.12","<9",""],["19 mo–10 y","<0.27","<20",""],["6–18 y","<0.19","<14",""],["Adult","<0.32","<24",""]],"p. 1397"],["S","mg/dL","µmol/L","75.1",[["0–< 2 wk","0.25–1.61","19–121","20"],["2 wk–<19 y","0.27–0.56","20–42",""]],"p. 1397"],["U, 24 h","mg/d","µmol/d","7.51",[["3–12 y","<5.1","<38","1"],["Adult","<26.2","<197",""]],"p. 1397"],["","mg/g creatinine","mmol/mol creatinine","0.85",[["Adult","0–4","0.1–3.7",""]],"p. 1397"]],"A1","p. 1397",32,{"sp":"P","nm":"Aspartic acid","n":"1","cvi":31.2,"cvg":55.1}],["Azelaic acid",[],[["U","","mmol/mol creatinine","",[["","","<1.1","1"]],"p. 1397"]],"A1","p. 1397",33],["Basophils",[],[["Sysmex XN-3000","103/µL","109/L","1",[["0–20 y","0.0–0.1","0.0–0.1","29, 42, 53"]],"p. 1461"],["Beckman Coulter DxH 900","103/µL","109/L","1",[["0–20 y","0.0–0.1","0.0–0.1","29, 42, 53"]],"p. 1461"],["Beckman Coulter HmX","103/µL","109/L","1",[["3–5 y","0.0–0.1","0.0–0.1","29, 42, 53"],["6–79 y","0.0–0.9","0.0–0.9","29, 42, 53"]],"p. 1461"]],"A4","p. 1461",1,{"sp":"B","nm":"Basophile, count","n":"3","cvi":28.0,"cvg":54.8}],["Beryllium",[],[["","None detected","None detected","0.111",[["Toxic",">20",">2.22",""]],"p. 1397"]],"A1","p. 1397",34],["Bilirubin",[],[["Amf","mg/dL","µmol/L","17.1",[["28 wk","<0.075","<1.28",""]],"p. 1449"],["","ΔA450 <0.048","","",[["40 wk","<0.025","<0.43",""]],"p. 1449"]],"A2","p. 1449",3],["Bilirubin, direct (conjugated)",["Values (0–<19 y) based on","Abbott Architect method"],[["S","mg/dL","µmol/L","17.1",[["0–14 d","0.33–0.71","5.7–12.1","7"],["15 d–<1 y","0.05–0.30","0.8–5.2",""],["1–<9 y","0.05–0.20","0.8–3.4",""],["9–<13 y","0.10–0.29","0.8–5.0",""],["13–<19 y, F","0.10–0.39","1.7–6.7",""],["13–<19 y, M","0.11–0.42","1.9–7.1",""]],"p. 1397"]],"A1","p. 1397",35,{"sp":"S","nm":"Bilirubin conjugated","n":"2","cvi":36.8,"cvg":43.2}],["Bilirubin, total",["Values (0–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","OCD Vitros method","Conjugated","Biotin"],[["S","mg/dL","µmol/L","17.1",[["0–14 d","0.19–16.6","3.3–283.8","7"],["15 d–<1 y","0.05–0.68","0.8–11.7",""],["1–<3 y","0.05–0.40","0.8–6.8",""],["3–5 y","0.1–0.5","1.0–8.8","27"],["6–15 y","0.1–0.9","1.0–15.6",""],["16–48 y, M","0.2–1.1","3.0–18",""],["F","0.1–0.9","1.0–16",""],["49–79 y, M","0.1–1.2","2.0–19.9",""],["F","0.1–1.0","1.0–16.6",""]],"p. 1397"],["Amf","Negative","Negative","17.1",[["See Table A.2","","",""]],"p. 1397"],["S","Negative","Negative","17.1",[["","0.0–0.2","0.0–3.4",""]],"p. 1397"],["WB","Negative","Negative","17.1",[["Healthy","","0.5–2.20 nmol/L","1"],["Deficiency","","<0.5 nmol/L",""]],"p. 1397"]],"A1","p. 1397",36,{"sp":"S","nm":"Bilirubin total","n":"11","cvi":21.8,"cvg":28.4}],["Bromide as bromine",[],[["S or P","µg/mL","mmol/L","0.0125",[["Therap","750–1500","9–19",""],["Toxic",">1250",">16",""]],"p. 1451"]],"A3","p. 1451",9],["Bupropion (Wellbutrin, Zyban)",[],[["or P","ng/mL","nmol/L","3.62",[["Therap","25–100","91–362",""],["Toxic",">100",">362",""]],"p. 1451"]],"A3","p. 1451",10],["C-reactive protein (CRP), high sensitivity",["Values (0–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","OCD Vitros method"],[["S","mg/L","mg/L","1",[["0–14 d","0.3–6.1","0.3–6.1","7"],["15 d–<3 y","0.1–1.0","0.1–1.0",""],["3–5 y","0.1–2.4","0.1–2.4","28"],["6–11 y","0.1–5.9","0.1–5.9",""],["12–13 y","0.1–1.9","0.1–1.9",""],["14–16 y","0.1–2.9","0.1–2.9",""],["17–39 y, M","0.1–6.0","0.1–6.0",""],["F","0.1–12.1","0.1–12.1",""],["40–79 y","0.1–8.8","0.1–8.8",""],["M","","",""],["American","0.3–8.6","0.3–8.6","1"],["White","0.2–12.3","0.2–12.3",""],["American","","",""],["African","0.1–8.2","0.1–8.2",""],["American","","",""],["Mexican","0.2–6.3","0.2–6.3",""],["American","","",""],["European","0.3–8.6","0.3–8.6",""],["Japanese","<7.8","<7.8",""],["F","","",""],["American","0.2–9.1","0.2–9.1",""],["European","0.3–8.8","0.3–8.8",""]],"p. 1403"]],"A1","p. 1403",74,{"sp":"S","nm":"C reactive protein - high sensitivity","n":"1","cvi":49.7,"cvg":89.23}],["C-Telopeptide",["Values (0–<19 y) based on","Abbott Architect method"],[["S","ng/L","ng/L","1",[["0–<1 y","210–4390","210–4390","14"],["1–<6 y","350–4480","350–4480",""],["6–<19 y","780–6790","780–6790",""],["Men","<1009","<1009","1"],["Premenopausal women","<574","<574",""]],"p. 1404"],["U, 24 h","mg/mol creatinine","mg/mol creatinine","1",[["Men","0–505","0–505","1"],["Premenopausal women","0–476","0–476",""]],"p. 1404"]],"A1","p. 1404",79],["Cadmium",[],[["WB (Hep)","µg/L","nmol/L","8.897",[["Nonsmokers","0.3–1.2","2.7–10.7","1"],["Smokers","0.6–3.9","5.3–34.7",""]],"p. 1397"],["U, 24 h","µg/L","µmol/L","8.897",[["Toxic range","100–3000","0.9–26.7",""]],"p. 1397"]],"A1","p. 1397",37],["Caffeine",[],[["S or P","µg/mL","µmol/L","5.15",[["Therap","8–20","41–103",""],["Toxic",">20",">103",""]],"p. 1451"]],"A3","p. 1451",11],["Calcitonin",[],[["S, P","pg/mL","ng/L","1",[["Men","<8.8","<8.8","1"],["Women","<5.8","<5.8",""],["Athyroidal","<0.5","<0.5",""]],"p. 1397"]],"A1","p. 1397",38],["Calcium, ionized (free)",[],[["S, P (Hep)","mg/dL","mmol/L","0.25",[["Adult","4.6–5.3","1.15–1.33","1"]],"p. 1397"]],"A1","p. 1397",39,{"sp":"S","nm":"Calcium, ionized","n":"2","cvi":1.7,"cvg":1.9}],["Calcium, total",["Values (0–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","OCD Vitros method"],[["S, P (Hep)","mg/dL","mmol/L","0.25",[["0–<1 y","8.5–11.0","2.13–2.74","7"],["1–<3 y","9.2–10.5","2.29–2.63",""],["3–5 y","9.4–10.6","2.35–2.64","27"],["6–15 y","9.3–10.5","2.33–2.62",""],["16–19","9.2–10.4","2.3–2.60",""],["20–39 y, M","9.1–10.4","2.28–2.60",""],["20–39 y, F","9.0–10.1","2.24–2.53",""],["40–79 y","9.0–10.2","2.24–2.56",""]],"pp. 1397–1398"]],"A1","pp. 1397–1398",40,{"sp":"S","nm":"Calcium","n":"24","cvi":2.1,"cvg":2.5}],["Cancer antigen 125",["Values (0–<19 y) based on","Abbott Architect method"],[["S","U/mL","kU/L","1",[["0–<4 mo","2.4–22","2.4–22","4"],["4 mo–<5 y","7.7–33","7.7–33",""],["5–<11 y","4.7–30","4.7–30",""],["11–<19 y, F","5.9–39","5.9–39",""],["11–<19 y, M","5.4–28","5.4–28",""],["Adult","<35","<35","1"]],"p. 1398"]],"A1","p. 1398",47],["Cancer antigen 15–3",["Values (0–<19 y) based on","Abbott Architect method"],[["S","U/mL","kU/L","1",[["0–<1 wk","3.4–24","3.4–24","4"],["1 wk–<1 y","4.9–33","4.9–33",""],["1–<19 y","3.9–21","3.9–21",""],["Adult","<30","<30","1"]],"p. 1398"]],"A1","p. 1398",42],["Cancer antigen 19–9",["Values (0–<19 y) based on","Abbott Architect method"],[["S","U/mL","kU/L","1",[["0–<1 y","<64","<64","4"],["1–<19 y","<41","<41",""],["Adult","<37","<37","1"]],"p. 1398"]],"A1","p. 1398",43],["Cancer antigen 242",[],[["S","U/mL","kU/L","1",[["","<20","<20","1"]],"p. 1398"]],"A1","p. 1398",48],["Cancer antigen 27.29",[],[["S","U/mL","kU/L","1",[["","<37.7","<37.7","1"]],"p. 1398"]],"A1","p. 1398",44],["Cancer antigen 50",[],[["S","U/mL","kU/L","1",[["","<14–20","<14–20","1"]],"p. 1398"]],"A1","p. 1398",45],["Cancer antigen 549",[],[["S","U/mL","kU/L","1",[["","<11","<11","1"]],"p. 1398"]],"A1","p. 1398",49],["Cancer antigen 72–4",[],[["S","U/mL","kU/L","1",[["","<6","<6","1"]],"p. 1398"]],"A1","p. 1398",46],["Carbamazepine (Tegretol)",[],[["S or P","µg/mL","µmol/L","4.23",[["Therap","4–12","17–51",""],["Toxic",">15",">63",""]],"p. 1451"]],"A3","p. 1451",12],["Carbamazepine-10, 11-epoxide (carbamazepine metabolite)",[],[["S or P","µg/mL","µmol/L","3.97",[["Therap","0.4–4","2–16",""],["Toxic",">8",">32",""]],"p. 1451"]],"A3","p. 1451",13],["Carbon dioxide, partial pressure (PCO2)",[],[["WB, arterial","mm Hg","kPa","0.133",[["Newborn","27–40","3.59–5.32","1"],["Infant","27–41","3.59–5.45",""],["Adult, M","35–48","4.66–6.38",""],["Adult, F","32–45","4.26–5.99",""]],"p. 1398"]],"A1","p. 1398",50],["Carbon dioxide, total (tCO2)",["Values (0–<6 y) based on","Abbott Architect method","Values (6–79 y) based on","OCD Vitros method"],[["S","mEq/L","mmol/L","1",[["0–14 d","5–20","5–20","7"],["15 d–<1 y","10–24","10–24",""],["1–<5 y","14–24","14–24",""],["5–<6 y","17–26","17–26",""],["6–79 y","19–26","19–26","27"]],"p. 1398"],["Arterial","mEq/L","mmol/L","1",[["","19–24","19–24",""]],"p. 1398"],["Venous","mEq/L","mmol/L","1",[["","22–26","22–26",""]],"p. 1398"]],"A1","p. 1398",51,{"sp":"B","nm":"CO2, total","n":"1","cvi":4.0,"cvg":4.8}],["Carbon monoxide",[],[["WB (EDTA)","%HbCO","HbCO Fraction","0.01",[["Nonsmokers","0.5–1.5","0.005–0.015","1"],["Smokers","","",""]],"p. 1398"],["","Conventional","HbCO Fraction","Conversion",[["1–2 packs/d","4–5","0.04–0.05",""],[">2 packs/d","8–9","0.08–0.09",""],["Toxic",">20",">0.20",""],["Lethal",">50",">0.5",""]],"p. 1399"]],"A1","pp. 1398–1399",52],["Carcinoembryonic antigen (CEA)",["Values based on the Roche","method","Catecholamines"],[["S","ng/mL","µg/L","1",[["Nonsmokers","<3","<3","1"],["Smokers","<5","<5",""]],"p. 1399"]],"A1","p. 1399",53,{"sp":"S","nm":"Carcinoembryonic antigen (CEA)","n":"10","cvi":12.7,"cvg":55.6}],["Ceruloplasmin",["Pediatric values (0–19 y)","based on Abbott Architect","method"],[["P","mg/L","g/L","0.001",[["Cord (term)","50–330","0.05–0.33",""],["0–<2 mo","74–237","0.07–0.24","14"],["2–<6 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P","µg/mL","µmol/L","3.09",[["Therap","10–25","31–77",""],["Toxic",">25",">77",""],["Gray baby syndrome",">40",">124","1"]],"pp. 1451–1452"]],"A3","pp. 1451–1452",15],["Chlordiazepoxide (Librium) + nordiazepine",[],[["S or P","ng/mL","µmol/L","0.003",[["Therap","700–1000","2–3",""],["Toxic",">5000",">17",""]],"p. 1452"]],"A3","p. 1452",16],["Chloride",[],[["(iontophoresis)","mEq/L","mmol/L","1",[["Normal","5–35","5–35",""],["Marginal","30–70","30–70",""],["Cystic fibrosis","60–200","60–200",""]],"p. 1449"]],"A2","p. 1449",4,{"sp":"S","nm":"Chloride","n":"19","cvi":1.2,"cvg":1.5}],["Chloride (Cl)",["Values (0–2 y) based on","Siemens EXL method","Values (3–79 y) based on","OCD Vitros method"],[["S, P","mEq/L","mmol/L","1",[["0–2 y","102–111","102–111","19"],["3–5 y","100–107","100–107","27"],["6–11 y","101–107","101–107",""],["12–29 y, M","101–106","101–106",""],["F","100–107","100–107",""],["30–79 y","102–108","102–108",""]],"p. 1400"],["U, 24 h","mEq/d","mmol/d","1",[["Infant","2–10","2–10",""],["Child <6 y","15–40","15–40",""],["6–10 y, M","36–110","36–110",""],["F","18–74","18–74",""],["10–14 y, M","64–176","64–176",""],["F","36–173","36–173",""],["Adult","110–250","110–250",""],[">60 y","95–195","95–195",""]],"p. 1400"],["Sweat (ionto-","mEq/d","mmol/d","1",[["See Table A.2","","",""]],"p. 1400"]],"A1","p. 1400",58,{"sp":"S","nm":"Chloride","n":"19","cvi":1.2,"cvg":1.5}],["Chlorpromazine (Thorazine)",[],[["S or P","ng/mL","nmol/L","3.14",[["Therap","","",""],["Adult","30–300","94–942",""],["Child","40–80","126–251",""],["Toxic",">750",">2355",""]],"p. 1452"]],"A3","p. 1452",17],["Cholesterol",["Values (0–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","OCD Vitros method","Clinical Decision Limits"],[["S","mg/dL","mmol/L","0.0259",[["0–14 d, F","46–125","1.20–3.23","7"],["0–14 d, M","42–109","1.09–2.82",""],["15 d–<1 y","64–237","1.66–6.14",""],["1–<3 y","112–208","2.90–5.39",""],["3–5 y","120–216","3.11–5.59","27"],["6–15 y","116–205","3.00–5.31",""],["16–19 y","100–182","2.59–4.71",""],["20–29 y","116–228","3.00–5.91",""],["30–39 y","147–266","3.81–6.89",""],["40–79 y","139–274","3.60–7.10",""]],"p. 1400"],["","disease through","management (2018","cholesterol",[["AHA/ACC/AACVPR/AAPA/","","",""],["ABC/ACPM/ADA/AGS/APhA/ASPC/","","",""]],"p. 1400"],["","Cholesterol). See","management (2018","Chapter 36",[["Coronary heart dis-","","","54"],["ease risk, Child","","",""],["Desirable","<170","<4.40",""],["Borderline high","170–199","4.40–5.15",""],["High",">200",">5.15",""],["Coronary heart dis-","","","55"],["ease risk, Adult","","",""],["Desirable","<200","<5.18",""],["Borderline high","200–239","5.18–6.19",""],["High",">239",">6.19",""]],"p. 1400"],["","should not be used on","risk prediction. See","its own for",[["Chapter 36.","","",""]],"p. 1400"]],"A1","p. 1400",59,{"sp":"S","nm":"Cholesterol","n":"46","cvi":5.95,"cvg":15.3}],["Cholinesterase",["Pediatric values (0–<19 y)","based on Abbott Architect","method","(37°C)"],[["","Conversion","Reference","0.017",[["0–14 d","4421–9722","75–165","7"],["15 d–<1 y","5182–16027","88–272",""],["1–<17 y","7769–15206","132–259",""],["17–<19 y, F","7511–10904","128–185",""],["17–<19 y, M","8186–12639","139–215",""],["Adult, M","40–78","0.68–1.33","1"],["F","33–76","0.56–1.29",""]],"p. 1401"]],"A1","p. 1401",60],["Cholinesterase activity with dibucaine inhibitor (ChEDi)",["Pediatric values (0–<19 y)","based on Abbott Architect","method"],[["S","U/L","µkat/L","0.017",[["0–<1 mo","797–2478","13–41","14"],["1 mo–<19 y","1523–3280","25–55",""]],"p. 1401"]],"A1","p. 1401",61],["Chorionic gonadotropin",["intact molecule"],[["S","mIU/mL","IU/L","1",[["Male and nonpreg-","<5.0","<5.0","1"],["nant female","","",""],["Female, pregnancy (wk of gestation)","","",""],["4 wk","5–100","5–100",""],["5 wk","200–3000","200–3000",""],["6 wk","10,000–80,000","10,000–80,000",""],["7–14 wk","90,000–500,000","90,000–500,000",""],["15–26 wk","5000–80,000","5000–80,000",""]],"p. 1401"],["","hCG.","International Standard for","the Second",[["Trophoblastic disease",">100,000",">100,000",""]],"p. 1401"]],"A1","p. 1401",62],["Chromium",[],[["WB (Hep)","µg/L","nmol/L","19.23",[["","0.7–28.0","14–538","1"]],"p. 1401"],["S","µg/L","nmol/L","19.23",[["","0.1–0.2","2–3",""]],"p. 1401"],["U, 24 h","µg/d","nmol/d","19.23",[["","0.1–2.0","1.9–38.4",""]],"p. 1401"],["RBC","µg/L","nmol/L","19.23",[["","20–36","384–692",""]],"p. 1401"]],"A1","p. 1401",63],["Chymotrypsin (37°C)",[],[["F","U/g stool","U/g stool","1",[["","12","12",""]],"p. 1401"]],"A1","p. 1401",64],["Cimetidine (Tagamet)",[],[["S or P","µg/mL","µmol/L","3.96",[["Therap","","",""],["Trough","0.5–1.2","2–5",""],["Toxic",">1.3",">5",""]],"p. 1452"]],"A3","p. 1452",18],["Ciprofloxacin (Cipro)",[],[["S or P","µg/mL","µmol/L","3.02",[["Therap","","",""],["Peak (oral dose)","0.5–1.5","2–5",""],["Peak (IV dose)","<5.0","<15",""],["Toxic",">5.0",">15",""],["Gram positive","","",""],["AUC/MIC",">30","",""],["Gram negative","","",""],["AUC/MIC",">125","",""]],"p. 1452"]],"A3","p. 1452",19],["cis-Aconitic acid",[],[["U","","mmol/mol creatinine","",[["0–1 mo","","5–31","1"],["1–6 mo","","10–97",""],["6 mo–5 y","","10–97",""],[">5 y","","3–44",""]],"p. 1392"]],"A1","p. 1392",4],["Citric acid",[],[["U","","mmol/mol creatinine","",[["0–1 mo","","<1046","1"],["1–6 mo","","104–268",""],["6 mo–5 y","","0–656",""],[">5 y","","87–639",""]],"p. 1401"]],"A1","p. 1401",66],["Clinical Decision Limits",[],[["","mg/dL","mmol/L","0.0259",[["Acceptable",">45",">1.2","54"],["Borderline","40–45","1.0–1.2",""],["Low","<40","<1.0",""],["Adult","","",""],["Low","<40","<1.0","55"],["High",">59",">1.5",""]],"p. 1413"]],"A1","p. 1413",119],["Clinical Decision Limits",["Lecithin-to-sphingomyelin","ratio"],[["","mg/dL","mmol/L","0.0259",[["Risk for coronary","","","54"],["heart disease,","","",""],["Child","","",""],["Acceptable","<110","<2.8",""],["Borderline","110–129","<3.3",""],["High",">130",">3.4",""],["Risk for coronary","","","55"],["heart disease,","","",""],["Adults","","",""],["Optimal","<100","<2.59",""],["Near/above optimal","100–129","2.59–3.34",""],["Borderline high","130–159","3.37–4.12",""],["High","160–189","4.15–4.90",""],["Very high",">189",">4.90",""]],"p. 1419"],["Amf","mg/dL","mmol/L","0.0259",[["See Table A.2","","","1"]],"p. 1419"]],"A1","p. 1419",154],["Clinical Decision Limits",[],[["","mg/dL","mmol/L","0.0113",[["cutoff points,","","",""],["Child 0–9 y","","",""],["Acceptable","<75","<0.9",""],["Borderline","75–99","0.9–1.1",""],["High 10–19 y","≥100",">1.1",""],["Acceptable","<90","<1.0",""],["Borderline","90–129","1.0–1.5",""],["High","≥130",">1.5",""]],"p. 1434"],["","mg/dL","mmol/L","0.0113",[["cutoff points,","","",""],["Adult","","",""],["Normal","<150","<1.70",""],["High","150–199","1.70–2.25",""],["Hypertriglyceridemic","200–499","2.26–5.64",""],["Very high",">499",">5.64",""]],"p. 1434"]],"A1","p. 1434",238],["Clomipramine (Anafranil) + norclomipramine",[],[["S or P","ng/mL","nmol/L","3.18",[["Therap","175–450","556–1431",""]],"p. 1452"]],"A3","p. 1452",20],["Clonazepam (Klonopin)",[],[["or P","ng/mL","nmol/L","3.17",[["Therap","20–70","63–222",""],["Toxic",">80",">254",""]],"p. 1452"]],"A3","p. 1452",21],["Clonidine (Catapres)",["Clorazepate (Tranxene) (see"],[["S or P","ng/mL","nmol/L","4.35",[["Therap","1.0–2.0","4–9","1"],["Toxic",">4.0",">17.4","56"]],"p. 1452"]],"A3","p. 1452",22],["Clozapine (Clozaril)",[],[["S or P","ng/mL","nmol/L","3.06",[["Therap","350–600","1071–1836",""],["Toxic",">900",">2754",""]],"p. 1452"]],"A3","p. 1452",23],["Cobalt",[],[["S","µg/L","nmol/L","16.97",[["","0.11–0.45","1.9–7.6","1"]],"p. 1401"],["U","µg/L","nmol/L","16.97",[["","1–2","17.0–34.0",""]],"p. 1401"],["RBC","µg/kg","nmol/kg","16.97",[["","16–46","272–781",""]],"p. 1401"]],"A1","p. 1401",67],["Codeine",[],[["S or P","ng/mL","nmol/L","3.34",[["Therap","10–100","33–334",""],["Toxic",">1100",">3340",""]],"p. 1452"]],"A3","p. 1452",24],["Complement C3",["Values (0–<19 y) based on","Abbott Architect method"],[["","Conventional","Reference","Conversion",[["0–14 d","50–121","0.5–1.2","7"],["15 d–<1 y","51–160","0.5–1.6",""],["1–<19 y","83–152","0.8–1.5",""],["Adult (20–60 y)","90–180","0.9–1.8","1"]],"p. 1402"]],"A1","p. 1402",68],["Complement C4",["Values (0–<19 y) based on","Abbott Architect method"],[["S","mg/dL","g/L","0.01",[["0–<1 y","7–30","0.1–0.3","7"],["1–<19 y","13–37","0.1–0.4",""],["Adult (20–60 y)","10–40","0.1–0.4","1"]],"p. 1402"]],"A1","p. 1402",69],["Copper",[],[["S","µg/dL","µmol/L","0.157",[["Birth–6 mo","20–70","3.1–10.9","1"],["Deficiency","<30","<5",""],["6y","90–190","14.1–29.8",""],["12 y","80–160","12.5–25.1",""],["Adult, M","70–140","10.9–21.9",""],["F","80–155","12.5–24.3",""],["Deficiency","50","8",""],["Pregnancy, at term","118–302","18.5–47.4",""]],"p. 1402"],["U, 24 h","µg/dL","µmol/L","0.157",[["Adult","<60 µg/24 h","1.0 µmol/24 h",""],["Wilson disease",">200 µg/24 h",">3 µmol/24 h",""]],"p. 1402"]],"A1","p. 1402",70,{"sp":"S","nm":"Copper","n":"2","cvi":4.7,"cvg":13.6}],["Corticosterone",["Pediatric values based on","LC-MS/MS"],[["S","µg/dL","nmol/L","28.84",[["0–<1 mo","0.00–0.69","0.14–20.0","16"],["1 mo–<1 y","0.01–0.53","0.28–15.4",""],["1–<4 y","0.02–0.13","0.62–3.72",""],["4–<6 y","0.03–0.14","0.95–4.11",""],["6–<15 y","0.02–0.32","0.44–9.19",""],["15–<19 y","0.03–0.53","0.85–15.24",""]],"p. 1402"]],"A1","p. 1402",71],["Cortisol, free",[],[["Sal","ng/mL","nmol/L","2.76",[["0700 h","1.4–10.1","4–30","1"],["2200 h","0.7–2.2","2–6",""]],"p. 1449"]],"A2","p. 1449",5],["Cortisol, free (see also",["Chapter 56)"],[["S","µg/dL","nmol/L","27.6",[["0800 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h","3–16","83–441",""]],"p. 1402"],["","Conversion","Reference","27.6",[["2000 h","<50% of 0800 h","<50% of 0800 h",""]],"p. 1403"]],"A1","pp. 1402–1403",73,{"sp":"S","nm":"Cortisol","n":"3","cvi":15.2,"cvg":38.1}],["Creatine kinase (CK)",["Pediatric reference values","(0 to <19 years) based on","Siemens ADVIA method","IFCC, 37°C","CK isoenzymes"],[["S","U/L","µkat/L","0.017",[["0–<13 y","68–293","1.16–4.98","19"],["13–<19 y, F","48–200","0.82–3.40",""],["13–<19 y, M","80–354","1.36–6.02",""],["M","46–171","0.78–2.90","1"],["F","34–145","0.58–2.47",""],["Fraction 2 (MB)","<5.0 µg/L","<5.0 µg/L","1"],["Relative index","<3.9%","<0.039 fractional",""]],"p. 1403"]],"A1","p. 1403",75,{"sp":"S","nm":"Creatine kinase (CK)","n":"9","cvi":22.8,"cvg":40.0}],["Creatinine",["Enzymatic S","Values (0–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","OCD Vitros method","Values (3–79 y) based on"],[["","mg/dL","µmol/L","88.4",[["0–14 d","0.32–0.92","28–81","7"],["15 d–<2 y","0.10–0.36","9–32",""],["2–<3 y","0.20–0.43","18–38",""],["3–5 y","0.31–0.51","28–45","27"],["6–7 y","0.36–0.56","32–49",""],["8–9 y","0.37–0.63","32–56",""],["10–11 y","0.43–0.68","38–60",""],["12–15 y, M","0.47–0.91","42–81",""],["12–16 y, F","0.48–0.84","42–74",""],["16–79 y, M","0.71–1.16","63–102",""],["17–79 y, F","0.56–0.96","49–85",""]],"p. 1403"],["U","mg/dL","mmol/L","0.0884",[["3–5 y","14.71–151.58","1–13","27"],["6–11 y","13.57–195.70","1–17",""],["12–13 y","21.49–214.93","2–19",""],["14–29 y","19.23–305.43","2–27",""],["30–79 y, M","14.71–294.12","1–26",""],["F","12.44–229.64","1–20",""]],"p. 1404"]],"A1","pp. 1403–1404",76,{"sp":"S","nm":"Creatinine","n":"28","cvi":5.95,"cvg":14.7}],["Cyanide",[],[["WB (Ox)","mg/L","µmol/L","38.5",[["Nonsmokers","<0.2","<7.7","1"],["Smokers","<0.4","<15.4",""]],"p. 1404"],["","toxicity","Up to 3850","38.5",[["Toxic",">1","38.5",""]],"p. 1404"]],"A1","p. 1404",80],["Cyclosporin A (Sandimmune)",[],[["WB","ng/mL","nmol/L","0.83",[["Therap","","",""],["12 h after dose","50–350","42–291",""],["Toxic",">350",">291",""]],"p. 1452"]],"A3","p. 1452",25],["Cystatin C",["Pediatric values (0–<19 y)","based on Abbott Architect","method"],[["S","mg/L","mg/L","1",[["0–<1 mo","1.49–2.85","1.49–2.85","14"],["1–<5 mo","1.01–1.92","1.01–1.92",""],["5 mo–<1 y","0.75–1.53","0.75–1.53",""],["1–<2 y, F","0.60–1.20","0.60–1.20",""]],"p. 1404"],["","Conventional","mg/L","Conversion",[["1–<2 y, M","0.77–1.85","0.77–1.85",""],["2–<19 y","0.62–1.11","0.62–1.11",""],["Adult, F","0.61–1.05","0.61–1.05","31"],["M","0.71–1.21","0.71–1.21",""]],"p. 1405"]],"A1","pp. 1404–1405",81,{"sp":"S","nm":"Cystatin C","n":"4","cvi":5.0,"cvg":13.0}],["Cystine",[],[["S","mg/dL","µmol/L","83.3",[["Premature, 1 d","0.54–1.02","45–85","1"],["Newborn, 1 d","0.43–1.01","36–84",""],["0–<6 d, F","0.19–0.61","16–51","20"],["0–<6 d, M","0.19–0.64","16–53",""],["6 d–<2 wk","0.08–0.68","6.7–57",""],["2 wk–<8 y","0.04–0.24","3.3–20",""],["8–<19 y","0.05–0.34","4.2–28",""],["Adult","0.40–1.40","33–117","1"]],"p. 1405"],["U, 24 h","mg/d","µmol/d","8.33",[["10 d–7 wk","2.16–3.37","18–28",""],["3–12 y","4.9–30.9","41–257",""],["Adult","<38.1","<317",""]],"p. 1405"],["","mg/g creatinine","mmol/mol creatinine","0.94",[["Adult","2–14","1.9–13.1",""]],"p. 1405"]],"A1","p. 1405",82,{"sp":"P","nm":"Cystine","n":"1","cvi":38.3,"cvg":48.5}],["Dehydroepiandrosterone sulfate",["Pediatric values (0–<19 y)","based on Abbott Architect","method","Tanner values based on Ab-","bott Architect method"],[["S","µg/dL","µmol/L","0.027",[["Children","","","14"],["0–<2 mo","1110–>1565","30.1–>42.5",""],["2–<6 mo","25–599","0.7–16.3",""],["6 mo–<1 y","6–184","0.2–5.0",""],["1–<6 y","3–117","0.1–3.2",""],["6–<9 y","5–159","0.2–4.3",""],["9–<13 y","35–281","0.9–7.6",""],["13–<16 y","58–479","1.6–13.0",""],["16–<19 y, F","152–595","4.1–16.1",""],["16–<19 y, M","129–700","3.5–19.0",""],["Pubertal levels,","","",""],["Tanner stage","","","1"],["1, M","5–265","0.1–7.2",""],["1, F","5–125","0.1–3.4",""],["2, M","15–380","0.4–10.3",""],["2, F","15–150","0.4–4.0",""],["3, M","60–505","1.6–13.6",""],["3, F","20–535","0.5–14.4",""],["4, M","65–560","1.8–15.1",""],["4, F","35–485","0.9–13.1",""],["5, M","165–500","4.4–13.5",""],["5, F","75–530","2.0–14.3",""]],"p. 1405"],["","Conventional","µmol/L","Conversion",[["Adult","","",""],["18–30 y, M","125–619","3.4–16.7",""],["18–30 y, F","45–380","1.2–10.3",""],["31–50 y, M","5–532","1.6–12.2",""],["31–50 y, F","12–379","0.8–10.2",""],["51–60 y, M","20–413","0.5–11.1",""],["61–83 y, M","10–285","0.3–7.7",""],["F, Postmenopausal 30–260","","0.8–7.0",""]],"p. 1406"]],"A1","pp. 1405–1406",84,{"sp":"S","nm":"Dehydroepiandrosterone sulfate (DHEAS)","n":"3","cvi":6.35,"cvg":30.7}],["Dehydroepiandrosterone, unconjugated",[],[["S","ng/dL","nmol/L","0.0347",[["Children","","","1"],["6–9 y, M","13–187","0.45–6.49",""],["6–9 y, F","18–189","0.62–6.55",""],["10–11 y, M","31–205","1.07–7.11",""],["10–11 y, F","112–224","3.88–7.77",""],["12–14 y, M","83–258","2.88–8.95",""],["12–14 y, F","98–360","3.40–12.5",""],["Adult","","",""],["M","180–1250","6.25–43.4",""],["F","130–980","4.51–34.0",""]],"p. 1405"]],"A1","p. 1405",83],["Delavirdine (Rescriptor)",[],[["S or P","µg/mL","µmol/L","1.80",[["Therap","","",""],["Trough","3–8","5–14",""],["Peak","14–16","25–29",""],["Toxic",">16",">29",""]],"p. 1452"]],"A3","p. 1452",26],["Deoxypyridinoline",[],[["","nine","µmol/mol creatinine","1",[["M","2.3–5.4","2.3–5.4","1"],["F, Premenopausal 3.0–7.4","","3.0–7.4",""]],"p. 1406"]],"A1","p. 1406",86],["Desipramine (Norpramin)",[],[["S or P","ng/mL","nmol/L","3.75",[["Therap","100–300","375–1126",""],["Toxic",">400",">1502",""]],"pp. 1452–1453"]],"A3","pp. 1452–1453",27],["Diazepam (Valium) + nordiazepine",[],[["S or P","ng/mL","nmol/L","3.51",[["Therap","100–1000","351–3512",""],["Toxic",">5000",">17,559",""]],"p. 1453"]],"A3","p. 1453",28],["Digitoxin",[],[["≥8 h after dose","ng/mL","nmol/L","1.31",[["Therap","10–30","13–39",""],["Toxic",">45",">59",""]],"p. 1453"]],"A3","p. 1453",29],["Digoxin (Lanoxin)",[],[["≥12 h after dose Therap","ng/mL","nmol/L","1.28",[["","0.5–2.0","0.6–3.0",""]],"p. 1453"],["In","ng/mL","nmol/L","1.28",[["heart failure","0.5–0.8","0.6–1.0",""]],"p. 1453"],["Toxic","ng/mL","nmol/L","1.28",[["",">1.5",">2.0",""]],"p. 1453"]],"A3","p. 1453",30],["Dihydrotestosterone",[],[["S","","nmol/L","0.0334",[["Child, prepubertal <3","","<0.10","1"],["Adult, M","30–85","1.03–2.92",""],["Adult, F","4–22","0.14–0.76",""]],"p. 1406"]],"A1","p. 1406",87],["Disopyramide (Norpace)",[],[["S or P","µg/mL","µmol/L","2.95",[["Therap","2.8–7.5","8–22",""],["Toxic",">5","> 15",""]],"p. 1453"]],"A3","p. 1453",31],["Dodecanedioic acid",[],[["U","","µmol/mol creatinine","",[["","","<0.06","1"]],"p. 1406"]],"A1","p. 1406",88],["Dopamine",["Epinephrine","*See Chapter 53, Table","53.1","Norepinephrine","*See Chapter 53, Table","53.1"],[["P","pg/mL","pmol/L","6.53",[["Supine (30 min)","<87","<475",""],["Sitting (15 min)","<87","<475",""],["Standing (30 min)","<87","<475",""]],"p. 1399"]],"A1","p. 1399",56],["Dopamine",["L-Dopa (1-dodecenoylcarni-","tine)","DOPAC (3,4-dihydroxyphen-","ylacetic acid)","DHPG (3,4-dihydroxyphenyl-","glycol)"],[["S","","nmol/L","",[["Adult, normoten- 1042–2366 sive","","5.3–12.0","1"],["674–2636","","4.0–15.7",""],["","797–1208","4.7–7.1",""]],"p. 1406"]],"A1","p. 1406",89],["Doxepin (Sinequan, Adapin) + nordoxepin",[],[["or P","ng/mL","nmol/L","3.58",[["Therap","50–150","179–537",""],["Toxic",">500",">1790",""]],"p. 1453"]],"A3","p. 1453",32],["DU-PAN-2",[],[["","U/mL","kU/L","1",[["","<401","<401","1"]],"p. 1406"]],"A1","p. 1406",90],["Efavirenz (Sustiva)",[],[["S or P","µg/mL","µmol/L","3.16",[["Therap","1–4","3–13",""],["Toxic",">4",">13",""]],"p. 1453"]],"A3","p. 1453",33],["Eosinophils",[],[["Sysmex XN-3000","103/µL","109/L","1",[["0–3 y","0.0–0.8","0.0–0.8","29, 42, 53"],["4–14 y","0.1–1.0","0.1–1.0","29, 42, 53"],["15–20 y","0.0–0.5","0.0–0.5","29, 42, 53"]],"p. 1461"],["Beckman Coulter DxH 900","103/µL","109/L","1",[["0–11 mo","0.1–0.9","0.1–0.9","29, 42, 53"],["1–12 y","0.1–0.5","0.1–0.5","29, 42, 53"],["13–20 y","0.1–0.5","0.1–0.5","29, 42, 53"]],"p. 1461"],["Beckman Coulter HmX","103/µL","109/L","1",[["3–5 y","0.0–0.5","0.0–0.5","29, 42, 53"],["6–11 y","0.0–0.5","0.0–0.5","29, 42, 53"],["12–79 y","0.1–0.2","0.1–0.2","29, 42, 53"]],"p. 1461"],["Reference","103/µL","109/L","1",[["Conventional","Conversion","Instrument/","29, 42, 53"]],"p. 1462"]],"A4","pp. 1461–1462",2,{"sp":"B","nm":"Eosinophils, count","n":"3","cvi":21.0,"cvg":76.4}],["Ephedrine (Ectasule)",[],[["S or P","µg/mL","µmol/L","6.05",[["Therap","0.05–0.10","0.3–0.6",""],["Toxic",">2",">12",""]],"p. 1453"]],"A3","p. 1453",34],["Epinephrine",[],[["P","pg/mL","pmol/L","5.46",[["Supine (30 min)","<50","<273",""],["Sitting (15 min)","<60","<328",""],["Standing (30 min)","<90","<491",""]],"p. 1399"]],"A1","p. 1399",54,{"sp":"P","nm":"Epinephrine","n":"1","cvi":48.3,"cvg":null}],["Estradiol",["Values (15 d–<19 y) based","on Abbott Architect","method","Tanner values based on Ab-","bott Architect method"],[["S","pg/mL","pmol/L","3.69",[["Child","","",""],["15 d–<1 y","<25","<92","15"],["1–<9 y, F","<10","<37",""],["9–<11 y, F","<48","<176",""],["11–<12 y, F","<94","<345",""],["12–<14 y, F","11–172","39–631",""],["14–<19 y, F","<255","<936",""],["1–<11 y, M","<13","<46",""],["11–<13 y, M","<26","<95",""],["13–<15 y, M","<28","<102",""],["15–<19 y, M","<38","<141",""],["Adult","","","1"],["M","10–50","37–184",""],["F","","",""],["Early follicular phase","20–150","73–550",""],["Late follicular phase","40–350","147–1285",""]],"p. 1406"],["","Conversion","Reference","3.69",[["Midcycle","150–750","550–2753",""],["Luteal phase","30–450","110–1652",""],["Postmenopausal <21","","<74",""],["Pubertal levels","","",""],["Tanner stage","","",""],["1, M","<19","<68","15"],["1, F","<20","<74",""],["2, M","<18","<67",""],["2, F","<26","<96",""],["3, M","<21","<76",""],["3, F","<86","<317",""],["4, M","<35","<128",""],["4, F","13–141","49–517",""],["5, M","17–34","64–126",""],["5, F","19–208","69–762",""]],"p. 1407"]],"A1","pp. 1406–1407",91,{"sp":"S","nm":"Estradiol","n":"5","cvi":22.5,"cvg":24.4}],["Estriol, free (unconjugated uE3)",["conjugated uE3)"],[["","ng/mL","nmol/L","3.47",[["16–20","1.0–3.2","3.5–11",""],["20–24","2.1–7.8","7.3–27",""],["24–28","2.1–7.8","7.3–27",""],["28–32","4.0–13.6","14–47",""],["32–36","3.6–15.5","12–54",""],["36–38","4.6–18.0","16–62",""],["38–40","5.4–19.8","19–69",""]],"p. 1449"]],"A2","p. 1449",6],["Estriol, free (unconjugated, uE3)",["uE3)","For LC-MSMS reference","intervals please see:","Clinical Biochemistry","2013;46:642–51"],[["S","ng/mL","nmol/L","3.47",[["Males and non-","<2.0","<6.9","1"],["pregnant females","","",""],["Pregnancy, wk of gestation","","",""],["16 wk","0.30–1.05","1.04–3.64",""],["18 wk","0.63–2.30","2.19–7.98",""],["34 wk","5.3–18.3","18.4–63.5",""],["35 wk","5.2–26.4","18.0–91.6",""],["36 wk","8.2–28.1","28.4–97.5",""],["37 wk","8.0–30.1","27.8–104.0",""],["38 wk","8.6–38.0","29.8–131.9",""],["39 wk","7.2–34.3","25.0–119.0",""],["40 wk","9.6–28.9","33.3–100.3",""]],"p. 1407"],["Amf","ng/mL","nmol/L","3.47",[["See Table A.2","","",""]],"p. 1407"]],"A1","p. 1407",92],["Estriol, total (E3)",[],[["S","ng/mL","nmol/L","3.47",[["Pregnancy, wk of gestation","","","1"],["34 wk","38–140","132–486",""],["35 wk","31–140","108–486",""],["36 wk","35–330","121–1145",""],["37 wk","45–260","156–902",""],["38 wk","48–350","167–1215",""],["39 wk","59–570","205–1978",""],["40 wk","95–460","330–1596",""]],"p. 1407"],["U, 24 h","µg/d","nmol/d","3.47",[["M","1.0–11.0","3.5–38.2",""],["F","","",""],["Follicular phase","0–15.0","0–52.0",""],["Ovulatory phase","13.0–54.0","45.1–187.4",""],["Luteal phase","8.0–60.0","27.8–208.2",""],["Postmenopausal","0–11.0","0–38.2",""],["Pregnancy","","",""]],"p. 1407"],["","Conventional","nmol/d","Conversion",[["1st trimester","0–800","0–2776",""],["2nd trimester","800–12,000","2776–41,640",""],["3rd trimester","5000–50,000","17,350–173,500",""]],"p. 1408"],["Amf","Conventional","nmol/d","Conversion",[["See Table A.2","","",""]],"p. 1408"]],"A1","pp. 1407–1408",93],["Estriol, total (E3)",[],[["Amf","ng/mL","nmol/L","3.47",[["21–32","5–50","17–174",""],["33–35","90–240","312–833",""],["36–41","150–213","521–739",""]],"p. 1449"]],"A2","p. 1449",7],["Estrone",[],[["S","pg/mL","pmol/L","3.69",[["M","15–65","55–240","1"],["F","","",""],["Early follicular phase","15–150","55–555",""],["Late follicular phase","100–250","370–925",""],["Luteal phase","15–200","55–740",""]],"p. 1408"]],"A1","p. 1408",94],["Ethanol",[],[["WB (Ox)","mg/dL","mmol/L","0.217",[["Impairment","50–100","11–22","1"],["Depression of",">100",">21.7",""],["CNS","","",""],["Fatalities reported >400","",">86.8",""]],"p. 1408"]],"A1","p. 1408",95],["Ethanol",[],[["WB (Ox)","mg/dL","mmol/L","0.217",[["Impairment","50–100","11–22",""],["Depression of CNS >100","",">21.7",""],["Fatalities reported",">400",">86.8",""]],"p. 1453"]],"A3","p. 1453",35],["Ethchlorvynol (Placidyl)",[],[["S or P","µg/mL","µmol/L","6.92",[["Therap","2–8","14–55",""],["Toxic",">20",">138",""]],"p. 1453"]],"A3","p. 1453",36],["Ethosuximide (Zarontin)",[],[["S or P","µg/mL","µmol/L","7.08",[["Therap","40–100","283–708",""],["Toxic",">150",">1062",""]],"p. 1453"]],"A3","p. 1453",37],["Ethylmalonic acid",[],[["U","","mmol/mol creatinine","",[["","","0.4–17","1"]],"p. 1408"]],"A1","p. 1408",96],["Everolimus (Zortress)",[],[["WB","ng/mL","nmol/L","1.04",[["Therap","3–15","3–16",""],["Toxic",">15",">16",""]],"p. 1453"]],"A3","p. 1453",38],["Felbamate (Felbatol)",[],[["S or P","µg/mL","µmol/L","4.2",[["Therap","30–60","126–252",""],["Toxic",">120",">504",""]],"p. 1453"]],"A3","p. 1453",39],["Fenoprofen (Nalfon)",[],[["S or P","µg/mL","µmol/L","4.12",[["Therap","20–65","82–268",""]],"p. 1453"]],"A3","p. 1453",40],["Ferritin",["Values (4 d–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","the Siemens Immulite","method"],[["S","ng/mL","µg/L","1",[["4–<15 d","99.6–717.0","99.6–717.0","3"],["15 d–<6 mo","14.0–647.2","14.0–647.2",""],["6 mo–<1 y","8.4–181.9","8.4–181.9",""],["1–<3 y","5.3–99.9","5.3–99.9",""],["3–5 y","10.7–85.2","10.7–85.2","28"],["6–16 y, M","16.2–106.7","16.2–106.7",""],["6–24 y, F","9.6–81.9","9.6–81.9",""],["17–37 y, M","39.3–439.4","39.3–439.4",""],["25–49 y, F","6.5–147.1","6.5–147.1",""],["38–79 y, M","45.8–714.8","45.8–714.8",""],["50–79 y, F","6.0–362.6","6.0–362.6",""]],"p. 1408"]],"A1","p. 1408",97,{"sp":"S","nm":"Ferritin","n":"6","cvi":14.2,"cvg":15.0}],["Fibrinogen",[],[["Clauss method,","mg/dL","g/L","0.01",[["12–13 y","180–350","1.8–3.5","29"]],"p. 1462"],["Photooptical clot detection (turbidity measurement)","mg/dL","g/L","0.01",[["14–39 y, M","210–370","2.1–3.7","29"],["14–39 y, F","200–420","2.0–4.2","29"],["40–79 y","200–420","2.0–4.2","29"]],"p. 1462"]],"A4","p. 1462",3],["Flecainide (Tambocor)",[],[["S or P","µg/mL","µmol/L","2.41",[["Therap","0.2–1.0","0.5–2.0",""],["Toxic",">1.0",">2.0",""]],"p. 1453"]],"A3","p. 1453",41],["Fluoride",[],[["S","mg/L","µmol/L","52.6",[["","0.2–3.2","10.5–168","1"]],"p. 1409"]],"A1","p. 1409",99],["Fluoxetine (Prozac) + norfluoxetine",[],[["S or P","ng/mL","nmol/L","3.23",[["Therap","120–300","388–969",""],["Toxic",">1000",">3230",""]],"p. 1453"]],"A3","p. 1453",43],["Fluphenazine (Modecate)",[],[["S or P","ng/mL","nmol/L","2.29",[["Therap","0.5–2","1–5",""],["Toxic",">100",">229",""]],"p. 1454"]],"A3","p. 1454",44],["Flurazepam (Dalmane) or",[],[["P","µg/mL","µmol/L","2.58",[["Therap",">0.002",">0.005","56"],["Toxic",">0.2",">0.5","1"]],"p. 1454"]],"A3","p. 1454",45],["Folate",["Values (5 d–<6 y) based on","Abbott Architect method","Values (6–79 y) based on","Siemens Immulite","method"],[["S","ng/mL","nmol/L","2.265",[["5 d–<1 y",">10.6",">23.9","3"],["1–<3 y",">3.9",">8.7",""],["3–<6 y",">11.9",">27.0",""],["6–18 y","8.2–30.6","18.6–69.3","28"],["19–79 y","9.5–39.0","21.5–88.4",""]],"p. 1409"],["Erythrocyte","ng/mL","nmol/L","2.265",[["3–5 y","294.7–883.4","703.1–2012.9","1"],["6–79 y","228.2–998.7","541.4–2110.6",""]],"p. 1409"],["","for erythrocytes","the level of supplemen-","depend on",[["tation in the country.","","",""]],"p. 1409"],["S","for erythrocytes","the level of supplemen-","depend on",[["Deficiency","<1.4","<3.2",""]],"p. 1409"],["Erythrocyte","for erythrocytes","the level of supplemen-","depend on",[["","<110","<252",""]],"p. 1409"]],"A1","p. 1409",100,{"sp":"B","nm":"Folate","n":"1","cvi":12.0,"cvg":66.0}],["Follicle-stimulating hormoneS (FSH)",["Values (30 d–<19 y) based","on Abbott Architect","method","Tanner values based on Ab-","bott Architect method","Fructosamine"],[["","mIU/mL","IU/L","1",[["30 d–<1 y, F","0.4–10.4","0.4–10.4","15"],["1–<9 y, F","0.4–5.5","0.4–5.5",""],["9–<11 y, F","0.4–4.2","0.4–4.2",""],["11–19 y, F","0.3–7.8","0.3–7.8",""],["30 d–<1 y, M","0.1–2.4","0.1–2.4",""],["1–<5 y, M","<0.9","<0.9",""],["5–<10 y, M","<1.6","<1.6",""],["10–<13 y, M","0.4–3.9","0.4–3.9",""],["13–<19 y, M","0.8–5.1","0.8–5.1",""],["Pubertal levels,","","",""],["Tanner stage","","",""],["1, M","<1.5","<1.5",""],["1, F","0.6–4.1","0.6–4.1",""],["2, M","<3.0","<3.0",""],["2, F","0.3–5.8","0.3–5.8",""],["3, M","0.4–6.2","0.4–6.2",""],["3, F","0.1–7.2","0.1–7.2",""],["4, M","0.6–5.1","0.6–5.1",""],["4, F","0.3–7.0","0.3–7.0",""],["5, M","0.8–7.2","0.8–7.2",""],["5, F","0.4–8.6","0.4–8.6",""],["23–70 y, M","1.4–15.4","1.4–15.4","1"],["F","","",""],["Follicular phase","1.4–9.9","1.4–9.9",""],["Midcycle peak 0.2–17.2","","0.2–17.2",""],["Luteal phase","1.1–9.2","1.1–9.2",""],["Postmenopausal","19.3–100.6","19.3–100.6",""]],"p. 1409"],["S","Conventional","Reference","Conversion",[["Child","5% below adult","","1"]],"p. 1410"],["","µmol/L","µmol/L","1",[["","205–285","205–285",""]],"p. 1410"]],"A1","pp. 1409–1410",101,{"sp":"S","nm":"Follicle stimulating hormone (FSH)","n":"5","cvi":11.0,"cvg":47.2}],["Fumaric acid",[],[["U","","mmol/mol creatinine","",[["0–1 mo","","10–45","1"],["1–6 mo","","4–45",""],["6 mo–5 y","","1–27",""],[">5 y","","2–4",""]],"p. 1410"]],"A1","p. 1410",102],["Gabapentin (Neurontin)",[],[["or P","µg/mL","µmol/L","5.84",[["Therap","2–20","12–117",""],["Toxic",">12",">70",""]],"p. 1454"]],"A3","p. 1454",46],["Gentamicin (Garamycin)",[],[["S or P","µg/mL","µmol/L","2.09",[["Therap","","",""],["Peak","","",""],["Less severe infection","5–8","11–17",""],["Severe infection","8–10","17–21",""],["Trough","","",""],["Less severe infection","<1","<2",""],["Moderate infection","<2","<4",""],["Severe infection","<4","<8",""],["Toxic","","",""],["Peak",">10",">21",""],["Trough",">2",">4",""],["Peak/MIC",">10",">21",""]],"p. 1454"]],"A3","p. 1454",47],["Glomerular filtration rate (endogenous)",["based on","KDIGO"],[["G1","mL/min/1.73 m2","mL/s/m2","0.00963",[["Normal or high","≥90","≥0.87","34"]],"p. 1410"],["G2","mL/min/1.73 m2","mL/s/m2","0.00963",[["Mildly decreased 60–89","","0.58–0.86",""]],"p. 1410"],["G3a","mL/min/1.73 m2","mL/s/m2","0.00963",[["Mildly to moder- 45–59","","0.43–0.57",""],["ately decreased","","",""]],"p. 1410"],["G3b","mL/min/1.73 m2","mL/s/m2","0.00963",[["Moderately to se-","30–44","0.29–0.42",""],["verely decreased","","",""]],"p. 1410"],["G4","mL/min/1.73 m2","mL/s/m2","0.00963",[["Severely decreased","15–29","0.14–0.28",""]],"p. 1410"],["G5","mL/min/1.73 m2","mL/s/m2","0.00963",[["Kidney failure","<15","<0.14",""]],"p. 1410"]],"A1","p. 1410",103],["Glucagon",[],[["P (Hep or","ng/L","ng/L","",[["Adult","70–180","70–180","1"]],"p. 1410"],["Amf","ng/L","ng/L","",[["See Table A.2","","",""]],"p. 1410"]],"A1","p. 1410",104],["Glucagon",[],[["Amf","ng/L","ng/L","1",[["Midgestation","23–63","23–63",""],["Term","41–193","41–193",""]],"p. 1449"]],"A2","p. 1449",8],["Glucose",[],[["S, fasting","mg/dL","mmol/L","0.0555",[["Cord","45–96","2.5–5.3","1"],["Premature","20–60","1.1–3.3",""],["Neonate","30–60","1.7–3.3",""],["Newborn","","",""],["1d","40–60","2.2–3.3",""],[">1 d","50–80","2.8–4.5",""],["Child","60–100","3.3–5.6",""],["Adult","74–100","4.1–5.6",""],[">60 y","82–115","4.6–6.4",""],[">90 y","75–121","4.2–6.7",""],["Decision Limits","","",""],["Normal glucose metabolism","≤100","≤5.55",""],["Diabetes","≥126","≥7.00",""]],"p. 1410"],["CSF","mg/dL","mmol/L","0.0555",[["See Table A.2","","",""]],"p. 1410"],["U","mg/dL","mmol/L","0.0555",[["","1–15","0.1–0.8",""]],"p. 1410"],["U, 24 h","g/d","mmol/d","5.55",[["","<0.5","<2.8",""]],"p. 1410"]],"A1","p. 1410",105,{"sp":"S","nm":"Glucose","n":"15","cvi":5.6,"cvg":7.5}],["Glucose",[],[["CSF","mg/dL","mmol/L","0.0555",[["Infant, child","60–80","3.3–4.5",""],["Adult","40–70","2.2–3.9",""]],"p. 1449"]],"A2","p. 1449",9],["Glucose-6-phosphate dehydrogenase (G-6-PD) EDTA, in erythrocytes, WHO and Hep) ICSH",[],[["(ACD,","U/g Hb","U/mmol Hb","64.5",[["","7.9–16.3","510–1050",""]],"p. 1410"],["","U/1012 RBC","nU/ RBC","10−3",[["","230–470","0.23–0.47",""],["","2.69–5.53 U/mL","2.69–5.53 U/mL RBC",""]],"p. 1410"]],"A1","p. 1410",106],["Glutamic acid",[],[["","Conversion","Reference","68",[["Premature, 1 d","0–1.98","0–135","1"],["Newborn, 1 d","0.29–1.57","20–107",""],["6 mo–3 y","0.28–1.47","19–100",""],["3–10 y","0.34–3.68","23–250",""],["6–18 y","0.10–0.96","7–65",""],["Adult","0.21–2.82","14–192",""]],"p. 1411"],["S","Conversion","Reference","68",[["0–<2 wk","1.34–5.90","91–401","20"],["2 wk–<1 y","1.09–3.91","74–266",""],["1<19 y","0.76–2.01","52–137",""]],"p. 1411"],["U, 24 h","mg/d","µmol/d","6.8",[["10 d–7 wk","0.3–1.5","2–10",""],["Adult","<33.8","<230",""]],"p. 1411"],["","mg/g creatinine","mmol/mol creatinine","0.77",[["Adult","2–6","1.5–4.7",""]],"p. 1411"]],"A1","p. 1411",107,{"sp":"P","nm":"Glutamic acid","n":"1","cvi":46.4,"cvg":79.9}],["Glutamine",[],[["P","mg/dL","µmol/L","68.5",[["3 mo–6 y","6.93–10.89","475–746","1"],["6–18 y","5.26–10.80","360–740",""],["Adult","5.78–10.38","396–711",""]],"p. 1411"],["S","mg/dL","µmol/L","68.5",[["0–<1 wk","6.58–16.2","451–1113","20"],["1 wk–<1 y","4.85–11.5","332–789",""],["1–<9 y","6.09–9.90","417–678",""],["9–<19 y","6.82–11.0","467–755",""]],"p. 1411"],["U, 24 h","mg/d","µmol/d","6.85",[["10 d–7 wk","12.4–25.8","85–177","1"],["3–12 y","20.4–113.7","140–779",""],["Adult","43.8–151.8","300–1040",""]],"p. 1411"],["","mg/g creatinine","mmol/mol creatinine","0.77",[["Adult","2–78","2–60",""]],"p. 1411"]],"A1","p. 1411",108,{"sp":"P","nm":"Glutamine","n":"1","cvi":12.1,"cvg":22.0}],["Glutaric acid",[],[["U","","mmol/mol creatinine","",[["","","0.5–13","1"]],"p. 1411"]],"A1","p. 1411",110],["Glutethimide (Doriden)",[],[["or P","µg/mL","µmol/L","4.60",[["Therap","2–6","9–28",""],["Toxic",">5",">23",""]],"p. 1454"]],"A3","p. 1454",48],["Glycated hemoglobin (HbA1C)",["Values (6–79 y) based on","OCD Vitros method"],[["WB (EDTA,","%","mmol/mol (IFCC)","",[["6–39 y","4.9–6.1","30–43","28"],["40–79 y","5.0–6.3","31–45",""],["Cutoff for diagnosis","≥6.5 (NGSP)","≥48","38"]],"p. 1411"]],"A1","p. 1411",111],["Glyceric acid",[],[["U","","mmol/mol creatinine","",[["0–1 mo","","<40","1"],["1–6 mo","","<185",""],["6 mo–5 y","","<71",""],[">5 y","","<61",""]],"p. 1411"]],"A1","p. 1411",112],["Glycine",[],[["P","mg/dL","µmol/L","133.3",[["Premature 1 d","0–7.57","0–1010","1"]],"p. 1411"],["","Conventional","µmol/L","Conversion",[["Newborn 1 d","1.68–3.86","224–514",""],["1–3 mo","0.79–1.67","106–222",""],["2–6 mo","1.31–2.22","175–296",""],["9 mo–2 y","0.42–2.31","56–308",""],["3–10 y","0.88–1.67","117–223",""],["6–18 y","1.18–2.27","158–302",""],["Adult","0.90–4.16","120–554",""]],"p. 1412"],["S","Conventional","µmol/L","Conversion",[["0–<2 wk","2.24–5.87","299–782","20"],["2 wk–<13 y","1.47–2.99","196–398",""],["13–<19 y","1.64–3.05","218–407",""]],"p. 1412"],["U, 24 h","mg/d","µmol/d","13.3",[["10 d–7 wk","14.6–9.2","194–787","1"],["3–12 y","12.4–106.8","165–1420",""],["Adult","59.0–294.6","785–3918",""]],"p. 1412"],["","mg/g creatinine","mmol/mol creatinine","1.51",[["Adult","12–108","18.2–163",""]],"p. 1412"]],"A1","pp. 1411–1412",113,{"sp":"P","nm":"Glycine","n":"1","cvi":11.8,"cvg":40.3}],["Glycolic acid",[],[["U","","mmol/mol creatinine","",[["0–1 mo","","<63","1"],["1–6 mo","","<105",""],["6 mo–5 y","","2–121",""],[">5 y","","<167",""]],"p. 1412"]],"A1","p. 1412",114],["Glyoxylic acid",[],[["U","","mmol/mol creatinine","",[["0–1 mo","","<14","1"],["1–6 mo","","<17",""],["6 mo–5 y","","<8",""],[">5 y","","<10",""]],"p. 1412"]],"A1","p. 1412",115],["Growth hormone",["Pediatric values (0–<19 y)","based on Beckman DxI","method"],[["S","ng/mL","µg/L","1",[["Basal","2–5","2–5","1"],["Insulin tolerance test",">10",">10",""],["Arginine",">7.5",">7.5",""],["L-Dopa",">7.5",">7.5",""],["0–<3 mo","0.80–33.5","0.80–33.5","12"],["3 mo–<2 y","0.14–6.27","0.14–6.27",""],["2–<7 y","0.05–5.11","0.05–5.11",""],["7–<12 y","0.02–4.76","0.02–4.76",""],["12–<14 y","0.01–6.20","0.01–6.20",""],["14–<19 y, F","0.03–5.22","0.03–5.22",""],["14–<19 y, M","0.02–3.81","0.02–3.81",""]],"p. 1412"]],"A1","p. 1412",116],["Haloperidol (Haldol)",[],[["S or P","ng/mL","nmol/L","2.66",[["Therap","5–17","13–45",""],["Toxic",">42",">112",""]],"p. 1454"]],"A3","p. 1454",49],["Haptoglobin",["Values (0–<19 y) based on","Abbott Architect method"],[["S","mg/dL","g/L","0.01",[["0–14 d","0–10","0–0.1","7"],["15 d–<1 y","7–221","0.1–2.2",""],["1–<12 y","7–163","0.1–1.6",""],["12–<19 y","7–179","0.1–1.8",""],["Adult (20–60 y)","30–200","0.3–2.0","1"]],"p. 1412"]],"A1","p. 1412",117,{"sp":"S","nm":"Haptoglobin","n":"3","cvi":20.4,"cvg":36.4}],["Hematocrit",[],[["Sysmex XN-3000","%","L/L","0.01",[["0–11 mo","28–39","0.28–0.39","29, 42, 53"],["1–3 y","31–39","0.31–0.39","29, 42, 53"],["4–13 y","34–43","0.34–0.43","29, 42, 53"],["14–20 y, M","39–50","0.39–0.50","29, 42, 53"],["14–20 y, F","35–45","0.35–0.45","29, 42, 53"]],"p. 1462"],["Beckman Coulter DxH 900","%","L/L","0.01",[["0–11 mo","27–40","0.27–0.40","29, 42, 53"],["1–3 y","30–40","0.30–0.40","29, 42, 53"],["4–13 y","34–42","0.34–0.42","29, 42, 53"],["14–20 y, M","39–48","0.39–0.48","29, 42, 53"],["14–20 y, F","34–44","0.34–0.44","29, 42, 53"]],"p. 1462"],["Beckman Coulter HmX","%","L/L","0.01",[["3–5 y","34–42","0.34–0.42","29, 42, 53"],["6–7 y","34–42","0.34–0.42","29, 42, 53"],["8–11 y","35–43","0.35–0.43","29, 42, 53"],["12–15 y, M","38–47","0.38–0.47","29, 42, 53"],["16–79 y, M","40–50","0.40–0.50","29, 42, 53"],["12–79 y, F","35–43","0.35–0.43","29, 42, 53"]],"p. 1462"]],"A4","p. 1462",4,{"sp":"B","nm":"Hematocrit","n":"11","cvi":2.7,"cvg":6.41}],["Hemoglobin",[],[["Sysmex XN-3000","g/dL","g/L","10",[["0–11 mo","9.3–12.9","93–129","29, 42, 53"],["1–3 y","10.0–13.2","100–132","29, 42, 53"],["4–13 y","11.2–14.1","112–141","29, 42, 53"],["14–20 y, M","12.9–16.7","129–167","29, 42, 53"],["14–20 y, F","11.2–15.1","112–151","29, 42, 53"]],"p. 1462"],["Beckman Coulter DxH 900","g/dL","g/L","10",[["0–11 mo","9.3–13.4","93–134","29, 42, 53"],["1–3 y","9.9–13.4","99–134","29, 42, 53"],["4–13 y","11.4–14.1","114–141","29, 42, 53"],["14–20 y, M","12.9–16.5","129–165","29, 42, 53"],["14–20 y, F","11.3–14.9","113–149","29, 42, 53"]],"p. 1462"],["Beckman Coulter HmX","g/dL","g/L","10",[["3–5 y","11.4–14.3","113.5–143.1","29, 42, 53"],["6–8 y","11.5–14.3","114.7–143.0","29, 42, 53"],["9–10 y","11.8–14.7","118.4–146.9","29, 42, 53"],["11–14 y, M","12.4–15.7","124.2–156.5","29, 42, 53"],["15–19 y, M","13.3–16.9","132.5–169.0","29, 42, 53"],["20–79 y, M","13.6–16.9","136–168.9","29, 42, 53"],["11–79 y, F","11.9–14.8","119.3–148.4","29, 42, 53"]],"p. 1462"]],"A4","p. 1462",5,{"sp":"B","nm":"Hemoglobin","n":"13","cvi":2.85,"cvg":6.8}],["High-density lipoprotein cholesterol (HDL-C)",["Values (0–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","OCD Vitros method"],[["S","mg/dL","mmol/L","0.0259",[["0–14 d","15–42","0.4–1.1","7"],["15 d–<1 y","12–71","0.3–1.9",""],["1–<3 y","32–63","0.8–1.6",""],["3–5 y","31–73","0.8–1.9","27"],["6–14 y","35–81","0.9–2.1",""],["15–79 y, M","31–70","0.8–1.8",""],["F","35–89","0.9–2.3",""]],"p. 1412"]],"A1","p. 1412",118],["Histidine",[],[["P","mg/dL","µmol/L","64.5",[["Premature, 1 d","0.16–1.40","10–90","1"],["Newborn, 1 d","0.76–1.77","49–114",""],["1–3 mo","0.66–1.30","43–83",""],["2–6 mo","1.49–2.12","96–137",""],["9 mo–2 y","0.37–1.74","24–112",""],["3–10 y","0.37–1.32","24–85",""],["6–18 y","0.99–1.64","64–106",""],["Adult","0.50–1.66","32–107",""]],"p. 1413"],["S","mg/dL","µmol/L","64.5",[["0–<2 wk","0.70–2.60","45–168","20"],["2 wk–<19 y","1.01–1.75","65–113",""]],"p. 1413"],["U, 24 h","mg/d","µmol/d","6.45",[["10 d–7 wk","16.0–38.6","103–249","1"],["3–12 y","47.4–199.2","306–1285",""],["Adult","72.9–440.8","470–2843",""]],"p. 1413"],["","mg/g creatinine","mmol/mol creatinine","0.73",[["Adult","1–141","1–103",""]],"p. 1413"]],"A1","p. 1413",121,{"sp":"P","nm":"Histidine","n":"1","cvi":9.7,"cvg":27.2}],["Homocysteine, total",["Values (5 d–<6 y) based on","Abbott Architect method","Values (6–79 y) based on","OCD Vitros method"],[["S, P","µmol/L","µmol/L","1",[["Folate-supple-","","","1"],["mented diet","","",""],["<15 y","<8","<8",""],["15–65 y","<12","<12",""],[">65 y","<16","<16",""],["No folate supplementation","","",""],["<15 y","<10","<10",""],["15–65 y","<15","<15",""],[">65 y","<20","<20",""],["5 d–<1 y","2.9–10.0","2.9–10.0","3"],["1–<6 y","2.8–7.6","2.8–7.6",""],["6–12 y","1.7–6.9","1.7–6.9","28"],["13–25 y, M","3.6–10.6","3.6–10.6",""],["13–39 y, F","2.9–9.5","2.9–9.5",""],["26–79 y, M","5.2–14.1","5.2–14.1",""],["40–79 y, F","3.7–10.9","3.7–10.9",""]],"p. 1413"]],"A1","p. 1413",122,{"sp":"P","nm":"Homocysteine","n":"3","cvi":8.3,"cvg":33.5}],["Homogentisic acid",[],[["U","","mmol/mol creatinine","",[["","","<11","1"]],"p. 1413"]],"A1","p. 1413",123],["Homovanillic acid (HVA)",[],[["U, 24 h","mg/d","µmol/d","5.49",[["3–6 y","1.4–4.3","8–24","1"],["6–10 y","2.1–4.7","12–26",""]],"p. 1413"],["","Conversion","Reference","5.49",[["10–16 y","2.4–8.7","13–48",""],["16–83 y","1.4–8.8","8–48",""]],"p. 1414"],["U","Conversion","Reference","5.49",[["*See Chapter 53","","",""],["Table 53.5","","",""]],"p. 1414"]],"A1","pp. 1413–1414",124],["Human Epididymis Protein 4 (HE4)",["Values based on Abbott Ar-","chitect method"],[["S","pmol/L","pmol/L","1.0",[["0–<1 wk","159–618","159–618","4"],["1 wk–<6 mo","55.7–178","55.7–178",""],["6 mo–<2 y","30.9–98.6","30.9–98.6",""],["2–<10 y","27.3–69.7","27.3–69.7",""],["10–<19 y","22.5–61.8","22.5–61.8",""]],"p. 1414"]],"A1","p. 1414",125],["Hydromorphone (Dilaudid)",[],[["S or P","ng/mL","nmol/L","3.50",[["Therap","1–3","4–11",""],["Toxic",">100",">350",""]],"p. 1454"]],"A3","p. 1454",50],["Hydroxyproline",[],[["P","mg/dL","µmol/L","76.3",[["Premature, 1 d","0–1.56","0–120","1"],["6–18 y, M","<0.66","<50",""],["6–18 y, F","<0.58","<44",""],["Adult, M","<0.55","<42",""],["Adult, F","<0.45","<34",""]],"p. 1415"],["U, 24 h","mg/d","µmol/d","7.63",[["Adult","<1.4","<11",""]],"p. 1415"],["","mg/g creatinine","mmol/mol creatinine","0.863",[["Adult","19–36","16–31",""]],"p. 1415"]],"A1","p. 1415",132,{"sp":"P","nm":"Hydroxyproline","n":"1","cvi":34.5,"cvg":56.7}],["Ibuprofen (Motrin)",[],[["S or P","µg/mL","µmol/L","4.85",[["Therap","10–50","49–243",""],["Toxic",">200",">970",""]],"p. 1454"]],"A3","p. 1454",51],["Imipramine (Tofranil) + desipramine",[],[["S or P","ng/mL","nmol/L","3.57",[["Therap","150–300","536–1071",""]],"p. 1454"]],"A3","p. 1454",52],["Immunoglobulin A",["Values (0–<19 y) based on","Abbott Architect method"],[["S, P","mg/dL","g/L","0.01",[["0–<1 y","1–29","0.0–0.3","7"],["1–<3 y","4–90","0.0–0.9",""],["3–<6 y","26–147","0.3–1.5",""],["6–<14 y","47–221","0.5–2.2",""],["14–<19 y","53–287","0.5–2.9",""],["Adult (20–60 y)","70–400","0.7–4.0","1"],["Adult (>60 y)","90–410","0.9–4.1",""]],"p. 1415"],["Saliva","mg/dL","g/L","0.01",[["See Table A.2","","",""]],"p. 1415"],["CSF","mg/dL","g/L","0.01",[["See Table A.2","","",""]],"p. 1415"]],"A1","p. 1415",133,{"sp":"S","nm":"Immunoglobulin A","n":"7","cvi":5.4,"cvg":35.9}],["Immunoglobulin A",["Sal"],[["CSF","mg/dL","mg/L","10",[["","0.0–0.6","0.0–6.0",""],["","<11","<0.11",""]],"p. 1449"]],"A2","p. 1449",10],["Immunoglobulin D",[],[["S","IU/mL","kIU/L","1",[["Adult (20–60 y)","0–160","0–160","1"]],"p. 1415"],["","ng/mL","µg/L","1",[["","0–384","0–384",""]],"p. 1415"]],"A1","p. 1415",134],["Immunoglobulin E",["Values (0–<19 y) based on","Abbott Architect method"],[["S","kIU/L","µg/L","2.4",[["0–<7 y","<25–440","<60–1057","14"],["7–<19 y","<25–450","<60–1079",""],["Adult (20–60 y)","0–160","0–380","1"]],"p. 1415"]],"A1","p. 1415",135],["Immunoglobulin G",["Pediatric values (0–<19 y)","based on Abbott Architect","method"],[["S","mg/dL","g/L","0.01",[["0–14 d","320–1407","3.2–14.1","7"],["15 d–<1 y","108–702","1.1–7.0",""],["1–<4 y","316–1148","3.2–11.5",""],["4–<10 y","542–1358","5.4–13.6",""],["10–<19 y","658–1534","6.6–15.3",""],["Adult (20–60 y)","700–1600","7.0–16.0","1"],["Adult (>60 y)","600–1560","6.0–15.6",""],["See Table A.2","","",""]],"p. 1415"]],"A1","p. 1415",136,{"sp":"S","nm":"Immunoglobulin G","n":"6","cvi":4.5,"cvg":16.5}],["Immunoglobulin G",[],[["CSF","mg/dL","mg/L","10",[["","0–5.5","0–55",""]],"p. 1449"]],"A2","p. 1449",11],["Immunoglobulin M",["Values (0–<19 y) based on","Abbott Architect method"],[["S","mg/dL","g/L","0.01",[["0–14 d","5–35","0.1–0.4","7"],["15 d–13 wk","12–71","0.1–0.7",""],["13 wk–<1 y","16–86","0.2–0.9",""],["1–<19 y, F","48–186","0.5–1.9",""],["1–<19 y, M","39–151","0.4–1.5",""],["Adult (20–60 y)","40–230","0.4–2.3","1"],["Adult (>60 y)","30–360","0.3–3.6",""]],"pp. 1415–1416"],["CSF","mg/dL","g/L","0.01",[["See Table A.2","","",""]],"p. 1416"]],"A1","pp. 1415–1416",137,{"sp":"S","nm":"Immunoglobulin M","n":"5","cvi":5.9,"cvg":47.3}],["Immunoglobulin M",[],[["CSF","mg/dL","mg/L","10",[["","0.0–1.3","0–13",""]],"p. 1449"]],"A2","p. 1449",12],["Indinavir (Crixivan)",[],[["S or P","µg/mL","µmol/L","1.41",[["Therap","","",""],["Trough",">0.1",">0.14",""],["Peak","8–10","11–14",""],["Toxic",">10",">14",""]],"p. 1454"]],"A3","p. 1454",53],["Inhibin A",[],[["S","pg/mL","ng/L","1",[["M","1.0–3.6","1.0–3.6","1"],["F (cycling; days of cycle)","","",""],["Early follicular phase (−14 to −10 d)","5.5–28.2","5.5–28.2",""],["Midfollicular phase (−9 to −4 d)","7.9–34.5","7.9–34.5",""],["Late follicular phase (−3 to −1 d)","19.5–102.3","19.5–102.3",""],["Midcycle (d 0) 49.9–155.5","","49.9–155.5",""],["Early luteal (1–3 d)","35.9–132.7","35.9–132.7",""],["Midluteal (4–11 d)","13.2–159.6","13.2–159.6",""],["Late luteal (12–14 d)","7.3–89.9","7.3–89.9",""],["IVF, peak levels","354–1690","354–1690",""],["PCOS, ovulatory","5.7–16.0","5.7–16.0",""],["Postmenopausal1.0–3.9","","1.0–3.9",""]],"p. 1416"]],"A1","p. 1416",138],["Insulin",["Values (0–<6 y) based on","Abbott Architect method","Values (6–79 y) based on","Siemens Immulite and","ADVIA Centaur methods"],[["S","µIU/mL","pmol/L","6",[["0–<1 y","1.0–23.4","7–163","14"],["1–<6 y","1.3–40.2","9–279",""],["6–10 y","0.4–13.0","3–93","28"],["11–19 y","2.1–19.5","15–140",""],["20–79 y","2.4–21.8","17–157",""]],"p. 1416"]],"A1","p. 1416",139,{"sp":"S","nm":"Insulin","n":"4","cvi":21.1,"cvg":58.3}],["Insulin-like growth factor II",[],[["S","ng/mL","µg/L","1",[["Child","","","1"],["Prepubertal","334–642","334–642",""],["Pubertal","245–737","245–737",""],["Adult","288–736","288–736",""],["GH deficiency","51–299","51–299",""]],"p. 1417"]],"A1","p. 1417",141],["Insulin-like growth factor-I",[],[["S","ng/mL","µg/L","1",[["1–2 y","","","1"],["M","31–160","31–160",""],["F 3–6 y","11–206","11–206",""],["M","16–288","16–288",""],["F 7–10 y","70–316","70–316",""],["M","136–385","136–385",""],["F 11–12 y","123–396","123–396",""],["M","136–440","136–440",""],["F 13–14 y","191–462","191–462",""],["M","165–616","165–616",""],["F 15–18 y","286–660","286–660",""],["M","134–836","134–836",""],["F 19–25 y","152–660","152–660",""]],"p. 1416"],["","Conversion","µg/L","1",[["M","202–433","202–433",""],["F Adult (25–85 y)","231–550","231–550",""],["M","135–449","135–449",""],["F","135–449","135–449",""]],"p. 1417"]],"A1","pp. 1416–1417",140],["Iodine",["Values based on manual","microplate analysis"],[["U","µg/dL","µmol/L","0.079",[["3–5 y","5–83","0.39–6.58","27"],["6–79 y","1–49","0.09–3.88",""]],"p. 1417"]],"A1","p. 1417",142],["Iron",["Values based on Abbott Ar-","chitect method"],[["","µg/dL","µmol/L","0.179",[["0–<14 y","16–128","2.8–22.9","7"],["14–<19 y, F","20–162","3.5–29.0",""],["14–<19 y, M","31–168","5.5–30.0",""]],"p. 1417"]],"A1","p. 1417",143,{"sp":"S","nm":"Iron","n":"11","cvi":26.5,"cvg":23.2}],["Iron-binding capacity, total",["Values based on Siemens","ADVIA method"],[["S","µg/dL","µmol/L","0.179",[["0–<19 y","300–439","53.7–78.6","19"]],"p. 1417"]],"A1","p. 1417",144],["Isocitric acid",[],[["U","","mmol/mol creatinine","",[["0–1 mo","","0–368","1"],["1–6 mo","","0–67",""],["6 mo–5 y","","0–77",""],[">5 y","","16–99",""]],"p. 1417"]],"A1","p. 1417",145],["Isoleucine",[],[["P","mg/dL","µmol/L","76.3",[["Premature, 1 d","0.26–0.78","20–60","1"],["Newborn, 1 d","0.35–0.69","27–53",""],["1–3 mo","0.59–0.95","45–73",""],["2–6 mo","0.50–1.61","38–123",""],["9 mo–2 y","0.34–1.23","26–94",""],["3–10 y","0.37–1.10","28–84",""],["6–18 y","0.50–1.24","38–95",""],["Adult","0.48–1.28","37–98",""]],"p. 1417"],["S","mg/dL","µmol/L","76.3",[["0–<2 wk","0.33–1.69","25–129","20"],["2 wk–<1 y","0.39–1.48","30–113",""],["1<12 y","0.56–1.69","43–129",""],["12–<19 y, F","0.42–0.89","32–68",""],["12–<19 y, M","0.69–1.66","53–127",""]],"p. 1417"],["","Trace-0.4","Trace-3","7.62",[["3–12 y","2–7","15–53",""],["Adult","5–24","38–183",""]],"p. 1417"],["","mg/g creatinine","mmol/mol creatinine","0.86",[["Adult","1–5","0.8–4.4","1"]],"p. 1417"]],"A1","p. 1417",146,{"sp":"P","nm":"Isoleucine","n":"1","cvi":15.5,"cvg":45.5}],["Isoniazid (Hyzyd, Nydrazid)",[],[["S or P","µg/mL","µmol/L","7.29",[["Therap","1–7","7–15",""],["Toxic",">20",">146",""]],"p. 1454"]],"A3","p. 1454",54],["Itraconazole (Sporanox) + hydroxyitraconazole",[],[["or P","µg/mL 1.42","µmol/L","",[["Therap",">1.5",">2",""]],"p. 1455"]],"A3","p. 1455",55],["Jaffe",[],[["S","mg/dL","µmol/L","88.4",[["Cord","0.60–1.20","53–106","1"],["0–14 d","0.42–1.05","37–93","7"],["15 d–<1 y","0.31–0.53","28–47",""],["1–<4 y","0.39–0.55","34–48",""],["4–<7 y","0.44–0.65","39–57",""],["7–<12 y","0.52–0.69","46–61",""],["12–<15 y","0.57–0.80","50–71",""],["15–<17 y, F","0.59–0.86","52–76",""],["M","0.65–1.04","58–92",""],["17–<19 y, F","0.60–0.88","53–78",""],["M","0.69–1.10","61–97",""],["18–60 y, M","0.90–1.30","80–115","1"],["F","0.60–1.10","53–97",""],["60–90 y, M","0.80–1.30","71–115",""],["F","0.60–1.20","53–106",""],[">90 y, M","1.00–1.70","88–150",""],["F","0.60–1.30","53–115",""]],"p. 1404"]],"A1","p. 1404",77],["Jaffe, manual",["Creatinine clearance (see","Glomerular filtration rate)"],[["U, 24 h","mg/kg/d","µmol/kg/d","8.84",[["Infant","8–20","71–177","1"],["Child","8–22","71–194",""],["Adolescent","8–30","71–265",""],["Adult, M","14–26","124–230",""],["F","11–20","97–177",""]],"p. 1404"]],"A1","p. 1404",78],["Kanamycin (Kantrex)",[],[["S or P","µg/mL 2.06","µmol/L","",[["Therap","","",""],["Peak","25–35","52–72",""],["Trough","","",""],["Less severe infection","1–4","2–8",""],["Severe infection","4–8","8–17",""],["Toxic","","",""],["Peak",">35",">72",""],["Trough",">10",">21",""],["Peak/MIC",">10",">21",""]],"p. 1455"]],"A3","p. 1455",56],["L-Lactate",[],[["WB (Hep)","mg/dL","mmol/L","0.111",[["At bed rest","5–12","0.56–1.39","1"],["Venous","<22","<2.5",""],["Arterial","16–17","1.78–1.88",""]],"p. 1417"],["CSF","mg/dL","mmol/L","0.111",[["See Table A.2","","",""]],"p. 1417"],["U, 24 h","mg/dL","mmol/L","0.111",[["Adult","","",""]],"p. 1417"],["","mg/dL","mmol/mol creatinine","0.111",[["0–1 mo","","46–348",""],["1–6 mo","","57–346",""]],"p. 1417"],["","Conventional","mmol/mol creatinine","Conversion",[["6 mo–5 y","","21–38",""],[">5 y","","20–101",""]],"p. 1418"],["Gastric","Conventional","mmol/mol creatinine","Conversion",[["See Table A.2","","",""]],"p. 1418"]],"A1","pp. 1417–1418",147],["L-Lactate",[],[["CSF","mg/dL","mmol/L","0.0111",[["Female","5.4–18.9","0.6–2.1",""],["Male","8.1–19.8","0.9–2.2",""]],"p. 1449"],["","mg/dL","mmol/L","0.111",[["","9.1–18.8","1.01–2.09",""]],"p. 1449"]],"A2","p. 1449",13],["L/S ratio",[],[["Amf","","Ratio","1",[["Immature <1.5","","<1.5",""],["Transitional 1.6–2.4","","1.6–2.4",""],["Mature >2.5","",">2.5",""],["Diabetic >2.5","",">2.5",""]],"p. 1450"]],"A2","p. 1450",14],["Lactate dehydrogenase (LD)",["Pediatric values based on","Abbott Architect method"],[["S","U/L","µkat/L","0.017",[["0–<15 d","309–1222","5.25–20.8","7"],["15 d–<1 y","163–452","2.77–7.68",""],["1–<10 y","192–321","3.26–5.46",""],["10–<15 y, F","157–272","2.67–4.62",""],["10–<15 y, M","170–283","2.89–4.81",""],["15–<19 y","130–250","2.21–4.25",""],["Adult","125–220","2.1–3.7","1"]],"p. 1418"]],"A1","p. 1418",148,{"sp":"S","nm":"Lactate dehydrogenase (LDH)","n":"11","cvi":8.6,"cvg":14.7}],["Lamivudine (Epivir, 3TC)",[],[["S or P","µg/mL 4.36","µmol/L","",[["Therap",">0.4",">2",""]],"p. 1455"]],"A3","p. 1455",57],["Lamotrigine (Lamictal)",[],[["or P","µg/mL 3.91","µmol/L","",[["Therap","2.5–15","10–59","1"],["Toxic",">20",">78","56"]],"p. 1455"]],"A3","p. 1455",58],["Lead",[],[["WB (Hep)","µg/dL","µmol/L","0.0483",[["Child","<25","<1.21","1"],["Adult","<25","<1.21",""],["Toxic",">99",">4.78",""]],"p. 1418"],["U, 24 h","µg/L","µmol/L","0.0483",[["","<80","<0.39",""]],"p. 1418"]],"A1","p. 1418",149],["Leucine",[],[["P","mg/dL","µmol/L","76.3",[["Premature, 1 d","0.26–1.58","20–120","1"],["Newborn, 1 d","0.62–1.43","47–109",""],["1–3 mo","10.58–2.14","44–164",""],["9 mo–2 y","0.59–2.03","45–155",""],["3–10 y","0.73–2.33","56–178",""],["6–18 y","1.03–2.28","79–174",""],["Adult","0.98–2.29","75–175",""]],"p. 1418"],["S","mg/dL","µmol/L","76.3",[["0–< 1 wk","0.60–2.16","46–165","20"],["1 wk–<1 y","0.72–2.46","55–188",""],["1–<11 y","1.11–2.96","85–226",""],["11–<19 y, F","1.10–1.99","84–152",""],["11–<19 y, M","1.35–2.98","103–227",""]],"p. 1418"],["U, 24 h","mg/d","µmol/d","7.624",[["10 d–7 wk","0.9–2.0","7–15",""],["3–12 y","3–11","23–84",""],["Adult","2.6–8.1","20–62",""]],"p. 1418"],["","mg/g creatinine","mmol/mol creatinine","0.86",[["Adult","0–8","0–6.8",""]],"p. 1418"]],"A1","p. 1418",150,{"sp":"P","nm":"Leucine","n":"1","cvi":14.8,"cvg":44.0}],["Levetiracetam (Keppra)",[],[["or P","µg/mL 5.88","µmol/L","",[["Therap","12–46","71–270",""]],"p. 1455"]],"A3","p. 1455",59],["Lidocaine (Xylocaine)",[],[["≥45 min after","µg/mL 4.27","µmol/L","",[["Therap","1.5–5","6–12",""],["Toxic",">6",">26",""]],"p. 1455"]],"A3","p. 1455",60],["Lipase",["Values (0–<19 y) based on","Abbott Architect method","37°C"],[["S","U/L","µkat/L","0.017",[["0–<19 y","4–39","0.07–0.65","7"],["Adult","<38","<0.65","1"]],"p. 1418"]],"A1","p. 1418",151,{"sp":"S","nm":"Lipase","n":"3","cvi":32.2,"cvg":31.8}],["Lithium (Eskalith)",[],[["S or P","mEq/L 1.0","mmol/L","",[["Therap","0.5–1.2","0.5–1",""],["Toxic",">2",">2",""]],"p. 1455"]],"A3","p. 1455",61],["Lorazepam (Ativan)",[],[["S or P","ng/mL 3.11","nmol/L","",[["Therap","50–240","156–746","1"],["Toxic","300–600","933–1866","56"]],"p. 1455"]],"A3","p. 1455",62],["Low-density lipoprotein cholesterol (LDL-C) (calculated, Friedewald)",["Calculated pediatric values","based on Abbott Architect","Method"],[["","mg/dL","mmol/L","0.0259",[["0–<1 y","13.1–173","0.34–4.48","10"],["1–<10 y, F","58.7–128","1.52–3.32",""],["1–<10 y, M","47.1–121","1.22–3.14",""],["10–<19 y","45.6–131","1.18–3.40",""]],"p. 1418"]],"A1","p. 1418",152],["Low-density lipoprotein cholesterol (LDL-C) (measured)",["Reference Intervals","Values (6–79 y) based on","OCD Vitros method"],[["S","mg/dL","mmol/L","0.0259",[["6–24 y, F","46–143","1.2–3.7","27"]],"p. 1418"],["","Conventional","mmol/L","Conversion",[["25–49 y, M","62–189","1.6–4.9",""],["F","50–178","1.3–4.6",""],["50–79 y","73–189","1.9–4.9",""]],"p. 1419"],["","disease through","management (2018","cholesterol",[["AHA/ACC/AACVPR/AAPA/","","",""],["ABC/ACPM/ADA/AGS/APhA/ASPC/","","",""]],"p. 1419"]],"A1","pp. 1418–1419",153],["Luteinizing hormone (LH)",["Values (4 d–<19 y) based","on Abbott Architect","method","Tanner values based on Ab-","bott Architect method"],[["","mIU/mL","IU/L","1",[["4 d–<3 mo F","<2.4","<2.4","15"],["3 mo–<1 y F","<1.2","<1.2",""],["1–<10 y, F","<0.3","<0.3",""],["10–<13 y, F","<4.3","<4.3",""],["13–<15 y, F","0.4–6.5","0.4–6.5",""],["15–<17 y, F","<13.1","<13.1",""],["17–<19 y, F","<8.4","<8.4",""],["Pubertal levels,","","",""],["Tanner stage","","",""],["1, M","<1.2","<1.2",""],["1, F","<0.1","<0.1",""],["2, M","<1.2","<1.2",""],["2, F","<2.3","<2.3",""],["3, M","<2.3","<2.3",""],["3, F","<7.4","<7.4",""],["4, M","<4.9","<4.9",""],["4, F","0.3–6.7","0.3–6.7",""],["5, M","0.6–5.9","0.6–5.9",""],["5, F","0.4–21.2","0.4–21.2",""],["M (23–70 y)","1.2–7.8","1.2–7.8","1"],["F","","",""],["Follicular 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1421",164],["Methionine",[],[["P","mg/dL","µmol/L","67.7",[["Premature, 1 d","0.38–0.66","25–45","1"],["Newborn, 1 d","0.13–0.61","9–41",""],["1–3 mo","0.05–0.57","3–39",""],["2–6 mo","0.24–0.73","16–49",""],["9 mo–2 y","0.04–0.43","3–29",""],["3–10 y","0.16–0.24","11–16",""],["6–18 y","0.24–0.55","16–37",""],["Adult","0.09–0.60","6–40",""]],"p. 1421"],["S","mg/dL","µmol/L","67.7",[["0–<19 y","0.19–0.65","13–44","20"]],"p. 1421"],["U","mg/d","µmol/d","6.7",[["10 d–7 wk","0.1–1.9","0.7–13",""],["3–12 y","3–14","20–95",""],["Adult","<9.1","<63",""]],"p. 1421"],["","mg/g creatinine","mmol/mol creatinine","0.76",[["Adult","0–9.5","0–7.2",""]],"p. 1421"]],"A1","p. 1421",165],["Methotrexate (Trexall, Rheumatrex)",[],[["S or P","µg/mL 2.20","µmol/L","",[["Therap","","",""],["24–72 h after highdose therapy","0.05–0.45","0.1–1","56"],["Toxic","","",""],["24 h after highdose therapy","≥10","≥22",""],["48 h after highdose therapy","≥1","≥2",""],["72 h after highdose 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1421–1422",169],["Monocytes",[],[["Sysmex XN-3000","103/µL","109/L","1",[["0–4 y","0.37–1.45","0.37–1.45","29, 42, 53"],["5–20 y","0.27–0.81","0.27–0.81","29, 42, 53"]],"p. 1463"],["Beckman Coulter DxH 900","103/µL","109/L","1",[["0–1 y","0.4–1.1","0.4–1.1","29, 42, 53"],["2–4 y","0.3–1.1","0.3–1.1","29, 42, 53"],["5–20 y","0.3–0.8","0.3–0.8","29, 42, 53"]],"p. 1463"],["Beckman Coulter HmX","103/µL","109/L","1",[["3–5 y","0.3–0.9","0.3–0.9","29, 42, 53"],["6–44 y","0.2–0.8","0.2–0.8","29, 42, 53"],["45–79 y, M","0.3–0.9","0.3–0.9","29, 42, 53"],["45–79 y, F","0.2–0.8","0.2–0.8","29, 42, 53"]],"p. 1463"],["Reference","103/µL","109/L","1",[["Conventional","Conversion","Instrument/","29, 42, 53"]],"p. 1464"]],"A4","pp. 1463–1464",11,{"sp":"B","nm":"Monocytes, count","n":"3","cvi":17.8,"cvg":49.8}],["Morphine",[],[["S or P","ng/mL 3.50","nmol/L","",[["Therap","10–80","35–280",""],["Toxic",">200",">700",""]],"p. 1456"]],"A3","p. 1456",76],["Mycophenolate mofetil or (CellCept) as mycophenolic acid",[],[["P","µg/mL 3.12","µmol/L","",[["Therap","1.3–3.5","4–11",""],["Toxic",">12",">38",""]],"p. 1456"]],"A3","p. 1456",77],["Myoglobin",["Values based on OCD","Vitros method"],[["S","ng/mL","µg/L","1.0",[["0–<2 wk","13.9–234","13.9–234","8"],["2 wk–<1 y","7.29–60.9","7.29–60.9",""],["1–<13 y","15.1–50.3","15.1–50.3",""],["13–<19 y, F","11.7–47.3","11.7–47.3",""],["13–<19 y, M","16.7–206","16.7–206",""]],"p. 1422"]],"A1","p. 1422",170,{"sp":"S","nm":"Myoglobin","n":"2","cvi":13.9,"cvg":29.6}],["N-telopeptide (BCE = bone collagen equivalents)",[],[["S","nmol BCE/L","nmol BCE/L","1.0",[["Men","5.4–24.2","5.4–24.2","1"],["Premenopausal women","6.2–19.0","6.2–19.0",""]],"p. 1422"],["","creatinine","creatinine","1.0",[["Men","3–63","3–63",""],["Premenopausal women","5–65","5–65",""]],"p. 1422"]],"A1","p. 1422",173],["Nefazodone (Serzone) or",[],[["P","ng/mL 2.13","nmol/L","",[["Therap","25–2500","53–5325",""],["Toxic",">2500",">5325",""]],"p. 1456"]],"A3","p. 1456",78],["Nelfinavir (Viracept)",[],[["S or P","µg/mL","µmol/L","1.76",[["Therap",">1",">2",""],["Toxic",">6",">11",""]],"p. 1456"]],"A3","p. 1456",79],["Netilmicin (Netromycin)",[],[["or P","µg/mL 2.10","µmol/L","",[["Therap","","",""],["Peak","","",""],["Less severe infection","5–8","10–17",""],["Severe infection","8–10","17–21",""],["Less severe infection","<1","<2",""],["Moderate infection","<2","<4",""],["Severe infection","<4","<8",""],["Peak",">10",">21",""],["Trough",">2",">4",""]],"pp. 1456–1457"]],"A3","pp. 1456–1457",80],["Neutrophils",[],[["Sysmex XN-3000","103/µL","109/L","1",[["0–11 mo","0.7–5.8","0.7–5.8","29, 42, 53"],["1–20 y","1.5–6.8","1.5–6.8","29, 42, 53"]],"p. 1464"],["Beckman Coulter DxH 900","103/µL","109/L","1",[["0–11 mo","0.9–4.6","0.9–4.6","29, 42, 53"],["1–20 y","1.5–6.4","1.5–6.4","29, 42, 53"]],"p. 1464"],["Beckman Coulter HmX","103/µL","109/L","1",[["3–5 y","1.6–7.8","1.6–7.8","29, 42, 53"],["6–16 y, M","1.4–6.1","1.4–6.1","29, 42, 53"],["6–14 y, F","1.5–6.5","1.5–6.5","29, 42, 53"],["15–50 y, F","2.0–7.4","2.0–7.4","29, 42, 53"],["17–50 y, M","1.8–7.2","1.8–7.2","29, 42, 53"],["51–79 y","2.0–6.4","2.0–6.4","29, 42, 53"]],"p. 1464"]],"A4","p. 1464",12,{"sp":"B","nm":"Neutrophyles, count","n":"5","cvi":17.1,"cvg":32.8}],["Nevirapine (Viramune) or",[],[["P","µg/mL 3.76","µmol/L","",[["Therap",">3.5","<13.2",""],["Toxic",">12",">45.1",""]],"p. 1457"]],"A3","p. 1457",81],["Niacin",[],[["U, 24 h","mg/d","µmol/d","7.3",[["","2.4–6.4","17.5–46.7","1"]],"p. 1422"]],"A1","p. 1422",171],["Nickel",[],[["S or P (Hep)","µg/L","nmol/L","17",[["","0.14–1.0","2.4–17.0","1"]],"p. 1422"],["WB","µg/L","nmol/L","17",[["","1.0–28.0","17–476",""]],"p. 1422"],["24 h","µg/d","nmol/d","17",[["","0.1–10","2–170",""]],"p. 1422"]],"A1","p. 1422",172],["Non-HDL cholesterol (calculated)",["Calculated pediatric values","based on Abbott Architect","method"],[["S","mg/dL","mmol/L","0.0259",[["0–<1 y","27.8–202","0.72–5.22","10"],["1–<10 y, F","79.9–165","2.07–4.28",""],["1–<10 y, M","69.1–142","1.79–3.68",""],["10–<19 y","64.9–156","1.68–4.04",""]],"p. 1413"]],"A1","p. 1413",120],["Nordiazepine, active or metabolite of several benzodiazepines",[],[["P","ng/mL 3.76","nmol/L","",[["Therap","100–500","376–1880",""],["Toxic",">500",">1880",""]],"p. 1457"]],"A3","p. 1457",82],["Norepinephrine",[],[["P","pg/mL","pmol/L","5.91",[["Supine (30 min)","110–410","650–2423",""],["Sitting (15 min)","120–680","709–4019",""],["Standing (30 min)","125–700","739–4137",""]],"p. 1399"]],"A1","p. 1399",55,{"sp":"P","nm":"Norepinephrine","n":"1","cvi":19.5,"cvg":null}],["Nortriptyline (Aventyl)",[],[["S or P","ng/mL 3.80","nmol/L","",[["Therap","70–170","266–646",""],["Toxic",">500",">1900",""]],"p. 1457"]],"A3","p. 1457",83],["Nuclear matrix protein 22 (NMP-22)",[],[["S","U/mL","kU/L","1.0",[["","<10","<10","1"]],"p. 1422"]],"A1","p. 1422",174],["Olanzapine (Zyprexa)",[],[["S or P","ng/mL 3.20","nmol/L","",[["Therap","20–80","64–256",""],["Toxic",">1000",">3200",""]],"p. 1457"]],"A3","p. 1457",84],["Orotic acid",[],[["U","","mmol/mol creatinine","",[["0–1 mo","","1.4–5.3","1"],["1–6 mo","","1.0–3.2",""],["6 mo–5 y","","0.5–3.3",""],[">5 y","","0.4–1.2",""]],"p. 1422"]],"A1","p. 1422",175],["Osteocalcin",[],[["S","ng/mL","µg/L","1.0",[["Adult, M","3.0–13.0","3.0–13.0","1"],["Adult, F","","",""],["Premenopausal","0.4–8.2","0.4–8.2",""],["Postmenopausal","1.5–11.0","1.5–11.0",""]],"p. 1422"]],"A1","p. 1422",176,{"sp":"S","nm":"Osteocalcin","n":"5","cvi":6.35,"cvg":30.9}],["Oxalic acid",[],[["U","","mmol/mol creatinine","",[["0–1 mo","","51–931","1"],["1–6 mo","","7–567",""],["6 mo–5 y","","7–352",""],[">5 y","","<188",""]],"p. 1422"]],"A1","p. 1422",177],["Oxazepam (Serax)",[],[["S or P","µg/mL 3.49","µmol/L","",[["Therap","0.2–1.4","0.7–5","1"],["Toxic",">2.0",">7","56"]],"p. 1457"]],"A3","p. 1457",85],["Oxcarbazepine (Trileptal) as monohydroxy oxcarbazepine (MHD)",[],[["S or P","µg/mL 3.97","µmol/L","",[["Therap","3–35","12–139",""],["Toxic",">40",">159",""]],"p. 1457"]],"A3","p. 1457",86],["Oxycodone (Percodan) or",[],[["P","ng/mL 3.17","nmol/L","",[["Therap","10–100","32–317",""],["Toxic",">200",">634",""]],"p. 1457"]],"A3","p. 1457",87],["Oxygen, partial pressure (PO2 )",[],[["Arterial","mm Hg","kPa","0.133",[["","5.7–30.5","0.8–4.0","1"]],"p. 1422"],["Venous","mm Hg","kPa","0.133",[["","17.4–41.0","2.3–5.5",""]],"p. 1422"],["WB, arterial Birth","mm Hg","kPa","0.133",[["","8–24","1.06–3.19",""]],"p. 1422"],["5–10","mm Hg","kPa","0.133",[["min","33–75","4.39–9.96",""]],"p. 1422"],["","Conventional","kPa","Conversion",[["30 min","31–85","4.12–11.31",""],["1h","55–80","7.32–10.64",""],["1d","54–95","7.18–12.64",""],["2 d–60 y","83–108","11.04–14.36",""],[">60 y",">80","> 10.64",""],[">70 y",">70",">9.31",""],[">80 y",">60",">7.98",""],[">90 y",">50",">6.65",""]],"p. 1423"]],"A1","pp. 1422–1423",179],["Oxygen, saturation (sO2)",[],[["WB, arterial","Percent saturation","Fraction saturation","0.01",[["Newborn","40–90","0.40–0.90","1"],["Thereafter","94–93","0.94–0.98",""]],"p. 1423"]],"A1","p. 1423",180],["Oxytocin",[],[["P, EDTA","µU/mL","mU/L","1.0",[["M","1.1–1.9","1.0–1.9","1"],["F","","",""],["Nonpregnant","1.0–1.8","1.0–1.8",""],["Second stage of labor","3.2–5.3","3.2–5.3",""]],"p. 1423"]],"A1","p. 1423",181],["Pantothenic acid",[],[["WB","µg/L","µmol/L","0.0046",[["","344–583","1.57–2.66","1"]],"p. 1423"],["U, 24 h","mg/d","µmol/d","4.53",[["","1–15","5–68",""]],"p. 1423"]],"A1","p. 1423",182],["Paraldehyde (Paral)",[],[["S or P","µg/mL 7.57","µmol/L","",[["Therap","","",""],["Sedation","10–100","76–757",""],["Anesthesia",">200",">1514",""],["Toxic",">200",">1514",""],["Lethal",">500",">3785",""]],"p. 1457"]],"A3","p. 1457",88],["Parathyroid hormone, intact",["Values (6 d–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","DiaSorin LIAISON method"],[["S","pg/mL","pmol/L","0.106",[["6 d–<1 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coma","20–50","88–221",""],["Toxic",">10",">44",""]],"p. 1457"]],"A3","p. 1457",91],["Perphenazine (Apo- Perphenazine)",[],[["S or P","µg/mL","µmol/L","2.48",[["Therap","0.6–2.4","2–6",""],["Toxic",">12",">30",""]],"p. 1458"]],"A3","p. 1458",92],["pH (37°C)",[],[["WB, arterial","pH","pH","1.0",[["Cord blood","","","1"],["Arterial","7.18–7.38","7.18–7.38",""],["Venous","7.25–7.45","7.25–7.45",""],["Newborn","","",""],["Premature, 48 h","7.35–7.50","7.35–7.50",""],["Full term","","",""],["Birth","7.11–7.36","7.11–7.36",""],["5–10 min","7.09–7.30","7.09–7.30",""],["30 min","7.21–7.38","7.21–7.38",""],["1h","7.26–7.49","7.26–7.49",""],["1d","7.29–7.45","7.29–7.45",""],["Children, adults","","",""],["Arterial","7.35–7.45","7.35–7.45",""],["Venous","7.32–7.43","7.32–7.43",""],["Adults","","",""],["60–90 y","7.31–7.42","7.31–7.42",""],[">90 y","7.26–7.43","7.26–7.43",""]],"p. 1423"]],"A1","p. 1423",186,{"sp":"B","nm":"pH (pH units)","n":"1","cvi":0.2,"cvg":null}],["Phenacetin",[],[["S or P","µg/mL","µmol/L","5.58",[["Therap","1–30","6–167",""],["Toxic","50–250","279–1395",""]],"p. 1458"]],"A3","p. 1458",93],["Phenobarbital (Luminal) or",[],[["P","µg/mL","µmol/L","4.31",[["Therap","10–40","43–173",""],["Toxic","","",""],["Slowness, ataxia, nystagmus","35–80","151–345",""],["Coma, with reflexes","65–117","280–504",""],["Coma, without reflexes",">100",">431",""]],"p. 1458"]],"A3","p. 1458",94],["Phensuximide (Milontin) + norphensuximide",[],[["S or P","µg/mL","µmol/L","5.29",[["Therap","40–60","212–317",""]],"p. 1458"]],"A3","p. 1458",95],["Phenylalanine",[],[["Dry blood","mg/dL","µmol/L","60.5",[["","<2.1","<122","1"]],"p. 1424"],["P","mg/dL","µmol/L","60.5",[["Premature","2.0–7.5","121–454",""],["Newborn","1.2–3.4","73–205",""],["Phenylketonuric 2–3 d",">4.5",">272",""],["Phenylketonuric untreated","15–30","907–1815",""],["Adult","0.8–1.8","",""]],"p. 1424"],["S","mg/dL","µmol/L","60.5",[["0–<2 wk","0.81–1.77","49–107","20"],["2 wk–<1 y","0.86–1.92","52–116",""],["1–<19 y","0.91–1.67","55–101",""]],"p. 1424"],["U, 24 h","mg/d","µmol/d","6.05",[["10 d DiaSorin","1.2–1.7","7–10",""],["LIAISON 7 wk","","",""],["3–13 y","4.0–17.5","24–106",""],["Adult","<16.5","<100",""]],"p. 1424"],["","mg/g creatinine","mmol/mol creatinine","0.68",[["Adult","2–10","1.3–6.9",""]],"p. 1424"]],"A1","p. 1424",187,{"sp":"P","nm":"Phenylalanine","n":"1","cvi":9.5,"cvg":40.6}],["Phenylbutazone (Butazolidin)",[],[["S or P","µg/mL","µmol/L","3.24",[["Therap","50–100","162–324",""],["Toxic",">100",">324",""]],"p. 1458"]],"A3","p. 1458",96],["Phenytoin (Dilantin)",[],[["S or P","µg/mL","µmol/L","3.96",[["Therap","10–20","40–79",""],["Free","1.0–2.0","4–8",""],["Toxic",">20",">79",""]],"p. 1458"]],"A3","p. 1458",97],["Phosphatase, acid tartrate resistant 37°C",[],[["S","U/L","µkat/L","0.017",[["Children","3.4–9.0","0.05–0.15","1"],["Adult","1.5–4.5","0.03–0.08",""]],"p. 1424"]],"A1","p. 1424",190],["Phosphatase, alkaline (bone specific, by immunoabsorption)",["Phosphatase, alkaline","isoenzymes","Biliary","Liver","Bone","Placental"],[["S","U/L","U/L","1.0",[["Men","15.0–41.3","15.0–41.3","1"],["Premenopausal women","11.6–29.6","11.6–29.6",""]],"p. 1425"],["","Activity","Fraction Activity","NA",[["<1 y","3–6","0.03–0.06",""],["1–15 y","2–5","0.02–0.05",""],["Adult","1–3","0.01–0.03",""],["Pregnant women 1–3","","0.01–0.03",""],["Postmenopausal 0–12 women","","0.0–0.12",""],["<1 y","20–34","0.20–0.34",""],["1–15 y","22–34","0.22–0.34",""],["Adult","17–35","0.17–0.35",""],["Pregnant women 5–17","","0.05–0.17",""],["Postmenopausal 17–48 women","","0.17–0.48",""],["<1 y","20–30","0.20–0.30",""],["1–15 y","21–30","0.21–0.30",""],["Adult","13–19","0.13–0.19",""],["Pregnant women 8–14","","0.08–0.14",""],["Postmenopausal 8–21 women","","0.08–0.21",""],["<1 y","8–19","0.08–0.19",""],["1–15 y","5–17","0.05–0.17",""],["Adult","13–21","0.13–0.21",""],["Pregnant women 53–69","","0.53–0.69",""],["Postmenopausal 7–15 women","","0.07–0.15",""],["<1 y","1–3","0.01–0.03",""],["1–15 y","0–1","0.0–0.01",""],["Adult","0–2","0.0–0.02",""],["Pregnant women 3–6","","0.03–0.06",""],["Postmenopausal 0–2 women","","0.0–0.02",""],["<1 y","0–2","0.0–0.02",""],["1–15 y","0–1","0.0–0.01",""],["Adult","0–1","0.0–0.01",""],["Pregnant women 0–1","","0.0–0.01",""],["Postmenopausal 0–1 women","","0.0–0.01",""]],"p. 1425"]],"A1","p. 1425",192,{"sp":"S","nm":"Alkaline phosphatase","n":"22","cvi":6.45,"cvg":26.1}],["Phosphatase, alkaline IFCC, 37°C",["Values (0–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","OCD Vitros method"],[["S","U/L","µkat/L","0.017",[["0–14 d","90–273","1.50–4.55","7"],["15 d–<1 y","134–518","2.23–8.63",""],["1–<3 y","156–369","2.60–6.15",""],["3–5 y","144–327","2.45–5.56","27"],["6–10 y","153–367","2.60–6.24",""],["11–15 y, M","113–438","1.92–7.45",""],["11–15 y, F","64–359","1.09–6.10",""],["16–21 y, M","56–167","0.95–2.84",""],["16–29 y, F","44–107","0.75–1.82",""],["22–79 y, M","50–116","0.85–1.97",""],["30–79 y, F","46–122","0.78–2.07",""]],"p. 1424"]],"A1","p. 1424",191,{"sp":"S","nm":"Alkaline phosphatase","n":"22","cvi":6.45,"cvg":26.1}],["Phosphate",["Values (0–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","OCD Vitros method"],[["S","mg/dL","mmol/L","0.323",[["0–14 d","5.6–10.5","1.80–3.40","7"],["15 d–<1 y","4.8–8.4","1.54–2.72",""],["1–<3 y","4.3–6.8","1.38–2.19",""],["3–5 y","4.4–6.0","1.41–1.94","27"],["6–10 y","4.4–5.7","1.41–1.85",""],["11–15 y, M","3.8–5.9","1.24–1.91",""],["F","3.6–5.6","1.16–1.81",""],["16–47 y","2.9–4.7","0.95–1.52",""],["48–79 y, M","2.8–4.7","0.89–1.52",""],["F","3.1–4.8","0.99–1.54",""]],"p. 1424"],["U, 24 h","g/d","mmol/d","32.3",[["Adults","0.4–1.3","12.9–42.0",""]],"p. 1424"]],"A1","p. 1424",189,{"sp":"S","nm":"Phosphate","n":"17","cvi":8.15,"cvg":10.8}],["Pimelic acid",[],[["U","","mmol/mol creatinine","",[["","","<1.1","1"]],"p. 1425"]],"A1","p. 1425",193],["Platelet count",[],[["Sysmex XN-3000","103/µL","109/L","1",[["0–11 mo","253–552","253–552","29, 42, 53"],["1–11 y","203–431","203–431","29, 42, 53"],["11–20 y","173–361","173–361","29, 42, 53"]],"p. 1464"],["Beckman Coulter DxH 900","103/µL","109/L","1",[["0–11 mo","287–589","287–589","29, 42, 53"],["1–11 y","212–480","212–480","29, 42, 53"],["12–20 y","170–380","170–380","29, 42, 53"]],"p. 1464"],["Beckman Coulter HmX","103/µL","109/L","1",[["3–5 y","187.4–444.6","187.4–444.6","29, 42, 53"],["6–9 y","186.7–400.4","186.7–400.4","29, 42, 53"],["10–13 y","176.9–381.3","176.9–381.3","29, 42, 53"],["14–26 y, M","138.7–319.6","138.7–319.6","29, 42, 53"],["F","158.1–361.6","158.1–361.6","29, 42, 53"],["27–50 y, M","152.6–322.4","152.6–322.4","29, 42, 53"],["F","141.7–362.1","141.7–362.1","29, 42, 53"],["60–79 y","142.6–347.7","142.6–347.7","29, 42, 53"]],"p. 1464"]],"A4","p. 1464",13,{"sp":"B","nm":"Platelets, count","n":"7","cvi":9.1,"cvg":21.9}],["Porphobilinogen",[],[["U, 24 h","mg/L","µmol/L","4.42",[["","<2.26","<10","1"]],"p. 1425"]],"A1","p. 1425",194,{"sp":"U","nm":"Porphobilinogen","n":"1","cvi":17.0,"cvg":31.0}],["Porphyrins, total",[],[["U, 24 h","","nmol/L","",[["","","20–320","1"]],"p. 1425"],["Feces","","nmol/L g dry wt","",[["","","10–200",""]],"p. 1425"],["Erythrocytes","Conventional","µmol/L erythrocytes","Conversion",[["","","0.4–1.7",""]],"p. 1426"]],"A1","pp. 1425–1426",195,{"sp":"U","nm":"Porphyrins (total)","n":"1","cvi":40.0,"cvg":null}],["Posaconazole (Noxafil) or",[],[["P","µg/mL","µmol/L","1.43",[["Therap",">1.25",">2",""]],"p. 1458"]],"A3","p. 1458",98],["Potassium (K)",["Values (0–2 y) based on","Siemens ADVIA method","Values (3–79 y) based on","OCD Vitros method"],[["S","mEq/L","mmol/L","1.0",[["Premature cord","5.0–10.2","5.0–10.2","1"],["Premature, 48 h","3.0–6.0","3.0–6.0",""],["Newborn cord","5.6–12.0","5.6–12.0",""],["Newborn","3.7–5.9","3.7–5.9",""],["Infant","4.1–5.3","4.1–5.3",""],["0–<1 y, F","4.2–6.2","4.2–6.2","19"],["0–<1 y, M","4.3–6.7","4.3–6.7",""],["1–2 y","4.0–5.3","4.0–5.3",""],["3–5 y","3.9–4.6","3.9–4.6","27"],["6–79 y","3.8–4.9","3.8–4.9",""]],"p. 1426"],["U, 24 h","mEq/d","mmol/d","1.0",[["6–10 y","","",""],["M","17–54","17–54","1"],["F 10–14 y","8–37","8–37",""],["M","22–57","22–57",""],["F","18–58","18–58",""],["Adult","25–125","25–125",""]],"p. 1426"]],"A1","p. 1426",196,{"sp":"S","nm":"Potassium","n":"20","cvi":4.6,"cvg":5.6}],["Primidone (Mysoline) + phenobarbital",[],[["S or P","µg/mL","µmol/L","4.58",[["Therap","5–10","23–46",""],["Toxic",">15",">69",""]],"p. 1458"]],"A3","p. 1458",99],["Procainamide or",["(Pronestyl) + N-acet-"],[["P","µg/mL","µmol/L","4.25",[["Therap","4–10","17–42",""]],"p. 1458"]],"A3","p. 1458",100],["Progastrin-Releasing Peptide (ProGRP)",["Values based on Abbott","Architect method"],[["S","pg/mL","ng/L","1.0",[["0–<1 wk","535–1889","535–1889","4"],["1 wk–<6 mo","57–817","57–817",""],["6 mo–<1 y","25–198","25–198",""],["1–<12 y","22–129","22–129",""],["12–<19 y","17–83","17–83",""]],"p. 1426"]],"A1","p. 1426",197],["Proinsulin",[],[["S","pmol/L","pmol/L","1.0",[["","1.1–6.9","1.1–6.9","1"]],"p. 1426"]],"A1","p. 1426",198],["Prolactin",["Values (4 d–<19 y) based","on Abbott Architect","method","Tanner values based on Ab-","bott Architect method"],[["S","ng/mL","mIU/L","21.0",[["Cord blood","45–539","945–11319","1"],["4–<30 d","13–213","273–4473","15"],["30 d–<1 y","6–114","126–2394",""],["1–<19 y","4–23","84–483",""],["Puberty, Tanner stage","","",""],["1, M","3–20","63–420",""],["1, F","2–20","42–420",""],["2, M","4–19","84–399",""],["2, F","4–23","84–483",""],["3, M","4–23","84–483",""],["3, F","4–23","84–483",""],["4, M","6–20","126–420",""],["4, F","6–23","126–483",""],["5, M","7–32","147–672",""],["5, F","5–23","105–483",""],["Adult","","","1"],["M","3.0–14.7","63.0–308.7",""],["F","3.8–23.0","79.8–483.0",""],["Pregnancy, 3rd trimester","95–473","1995–9933",""]],"p. 1426"]],"A1","p. 1426",199,{"sp":"S","nm":"Prolactin","n":"4","cvi":23.0,"cvg":35.0}],["Proline",[],[["P","mg/dL","µmol/L","86.9",[["Premature, 1 d","0.92–4.36","80–380","1"],["Newborn, 1 d","1.23–3.18","107–277",""],["1–3 mo","0.89–3.73","77–325",""],["9 mo–2 y","0.59–2.13","51–185",""],["3–10 y","0.78–1.70","68–148",""],["6–18 y","0.67–3.72","58–324",""]],"p. 1427"],["S","mg/dL","µmol/L","86.9",[["0–<1 y","1.46–3.36","127–292","20"],["1–<13 y","1.36–4.28","118–372",""],["13–<19 y","1.33–4.14","116–360",""]],"p. 1427"],["U, 24 h","mg/dL","µmol/L","86.9",[["Adult","1.17–3.86","102–336","1"]],"p. 1427"],["","mg/d","µmol/d","8.69",[["10 d–7 wk","3.2–11.0","28–96",""]],"p. 1427"],["","µmol/g creatinine","µmol/mol creatinine","0.113",[["0–1 mo","70–2300","7.91–259.9",""],["1–6 mo","<600","<67.8",""],["6 mo–1 y","<300","<33.9",""],["1–2 y","<270","<30.5",""],["2–3 y","<220","<24.9",""]],"p. 1427"]],"A1","p. 1427",200,{"sp":"P","nm":"Proline","n":"1","cvi":17.0,"cvg":104.4}],["Propafenone (Rythmol) or",[],[["P","µg/mL","µmol/L","2.93",[["Therap","0.5–2.0","1.5–6",""],["Toxic",">2",">6",""]],"p. 1458"]],"A3","p. 1458",102],["Propionylcarnitine",[],[["P","","µmol/L","",[["0–7 d","","0.07–1.85","1"],["8 d–7 y","","0.17–1.27",""],[">7 y","","0.17–1.49",""]],"p. 1427"],["WB spots","","µmol/L","",[["","","0.55–8.01",""]],"p. 1427"],["Bile spots","","µmol/L","",[["","","0.36–8.10",""]],"p. 1427"],["U","","mmol/mol creatinine","",[["0–7 d","","0.01–0.20",""],["8 d–7 y","","0.01–1.20",""],[">7 y","","0.00–0.06",""]],"p. 1427"]],"A1","p. 1427",201],["Propoxyphene (Darvon) or",[],[["P","µg/mL","µmol/L","2.95",[["Therap","0.1–0.4","0.3–1.0",""],["Toxic",">0.5",">2",""]],"p. 1458"]],"A3","p. 1458",103],["Propranolol (Inderal)",[],[["S or P","ng/mL","nmol/L","3.86",[["Therap","20–100","77–386",""],["Toxic",">1000",">3860","56"],["Fatal",">2000",">7720",""]],"p. 1458"]],"A3","p. 1458",104],["Prostate-specific antigen (PSA)",[],[["S","ng/mL","µg/L","1.0",[["M","","","1"],["40–49 y","0–2.5","0–2.5",""],["50–59 y","0–3.5","0–3.5",""],["60–69 y","0–4.5","0–4.5",""],["70–79 y","0–6.5","0–6.5",""]],"p. 1427"]],"A1","p. 1427",202,{"sp":"S","nm":"Prostatic specific antigen (PSA)","n":"3","cvi":18.1,"cvg":72.4}],["Protein, total",["Values (0–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","OCD Vitros method"],[["Cord","g/dL","g/ L","10",[["","4.8–8.0","48–80","1"]],"p. 1427"],["S","g/dL","g/ L","10",[["Premature","3.6–6.0","36–60",""],["0–14 d","5.3–8.3","53–83","7"],["15 d–<1 y","4.4–7.1","44–71",""],["1–<3 y","6.1–7.5","61–75",""],["3–5 y","6.3–8.1","63–81","27"],["6–19 y","6.8–8.2","68–82",""],["20–29 y","6.5–8.3","65–83",""],["30–79 y","6.5–7.8","65–78",""]],"p. 1427"],["U, 24 h","mg/dL","mg/L","10",[["Adult","1–14","10–140",""]],"p. 1427"],["","mg/d","g/d","0.001",[["Adult","<100","<0.1",""],["Pregnancy","<150","<0.15",""]],"p. 1427"],["CSF","mg/d","g/d","0.001",[["See Table A.2","","",""]],"p. 1427"]],"A1","p. 1427",203,{"sp":"S","nm":"Protein","n":"18","cvi":2.75,"cvg":4.7}],["Protein, total",[],[["CSF","","mg/L","10",[["Premature 15–130","","150–1300",""],["Full-term newborn 40–120","","400–1200",""],["<1 mo 20","-80","200–800",""],[">1 mo 15–40","","150–400",""],["Ventricular fluid","5–15","50–150",""],["Cisternal fluid","15–25","150–250",""]],"p. 1450"],["Amf","","g/L","10",[["Early pregnancy 0.2–1.7","","2.0–17.0",""],["Late pregnancy 0.175–0.705","","1.8–7.1",""]],"p. 1450"]],"A2","p. 1450",15,{"sp":"S","nm":"Protein","n":"18","cvi":2.75,"cvg":4.7}],["Protriptyline (Vivactil)",[],[["S or P","ng/mL","nmol/L","3.80",[["Therap","70–260","266–988",""],["Toxic",">500",">1900",""]],"p. 1458"]],"A3","p. 1458",105],["Pyroglutamic acid",[],[["U","","mmol/mol creatinine","",[["","","<62","1"]],"p. 1428"]],"A1","p. 1428",204],["Pyruvate",[],[["CSF","","mmol/L","0.114",[["Adult 0.3–1.3","","0.03–0.15",""]],"p. 1450"]],"A2","p. 1450",16],["Pyruvic acid",[],[["WB, arterial Adult","mg/dL","µmol/L","0.114",[["","0.2–0.7","0.02–0.08","1"]],"p. 1428"],["WB, venous Adult","mg/dL","µmol/L","0.114",[["","0.3–0.9","0.03–0.10",""]],"p. 1428"],["CSF See","mg/dL","µmol/L","0.114",[["Table A.2","","",""]],"p. 1428"],["U, 24 h Adult","mg/dL","µmol/L","0.114",[["","","<1.1 mmol/d",""]],"p. 1428"],["U","mg/dL","mmol/mol creatinine","0.114",[["0–1 mo","","24–123",""],["1–6 mo","","8–90",""],["6 mo–5 y","","3–19",""],[">5 y","","6–9",""]],"p. 1428"]],"A1","p. 1428",205],["Quetiapine (Seroquel)",[],[["S or P","ng/mL 0.00261","µmol/L","",[["Therap","100–500","0.26–1.3",""],["Toxic",">1000",">2.6",""]],"p. 1459"]],"A3","p. 1459",106],["Quinidine (BioQuin)",[],[["S or P","µg/mL 3.08","µmol/L","",[["Therap","2–5","6–14",""],["Toxic",">6",">19",""]],"p. 1459"]],"A3","p. 1459",107],["Red blood cell count",[],[["Sysmex XN-3000","106/µL","1012/L","1",[["0–11 mo, M","3.00–5.18","3.00–5.18","29, 42, 53"],["0–11 mo, F","3.05–4.85","3.05–4.85","29, 42, 53"],["1–3 y","3.90–4.96","3.90–4.96","29, 42, 53"],["4–13 y, M","4.14–5.14","4.14–5.14","29, 42, 53"],["4–13 y, F","3.95–5.00","3.95–5.00","29, 42, 53"],["14–20 y, M","4.26–5.74","4.26–5.74","29, 42, 53"],["14–20 y, F","3.98–5.40","3.98–5.40","29, 42, 53"]],"p. 1464"],["Beckman Coulter DxH 900","106/µL","1012/L","1",[["0–11 mo","2.9–5.2","2.9–5.2","29, 42, 53"],["1–13 y, M","4.1–5.1","4.1–5.1","29, 42, 53"],["1–13 y, F","3.9–5.0","3.9–5.0","29, 42, 53"],["14–20, M","4.3–5.6","4.3–5.6","29, 42, 53"],["14–20, F","4.0–5.1","4.0–5.1","29, 42, 53"]],"p. 1464"],["Beckman Coulter HmX","106/µL","1012/L","1",[["3–5 y","4.0–5.1","4.0–5.1","29, 42, 53"],["6–10 y","4.1–5.2","4.1–5.2","29, 42, 53"],["11–14 y","4.2–5.3","4.2–5.3","29, 42, 53"],["15–49 y, M","4.3–5.7","4.3–5.7","29, 42, 53"],["50–79 y, M","4.2–5.5","4.2–5.5","29, 42, 53"],["15–79 y, F","3.8–5.0","3.8–5.0","29, 42, 53"]],"p. 1464"]],"A4","p. 1464",14,{"sp":"B","nm":"Erythrocytes, count","n":"7","cvi":3.2,"cvg":6.3}],["Red cell distribution width",[],[["Sysmex XN-3000","%","%","1",[["0–11 mo","12.0–17.0","12.0–17.0","29, 42, 53"],["1–13 y, M","11.9–15.3","11.9–15.3","29, 42, 53"],["1–13 y, F","11.5–14.5","11.5–14.5","29, 42, 53"],["14–21","11.5–15.6","11.5–15.6","29, 42, 53"]],"p. 1464"],["Beckman Coulter DxH 900","%","%","1",[["0–1 y","12.2–17.7","12.2–17.7","29, 42, 53"],["2–20 y","12.2–15.2","12.2–15.2","29, 42, 53"]],"p. 1464"],["Beckman Coulter HmX","%","%","1",[["3–5 y","11.3–13.4","11.3–13.4","29, 42, 53"],["6–80 y","11.4–13.5","11.4–13.5","29, 42, 53"]],"p. 1464"],["Instrument/","%","%","1",[["","Conventional","","29, 42, 53"]],"p. 1465"]],"A4","pp. 1464–1465",15,{"sp":"B","nm":"Red cell distribution wide (RDW)","n":"4","cvi":3.5,"cvg":5.7}],["Remnant cholesterol (calculated)",["Calculated pediatric values","based on Abbott Architect","method"],[["S","mg/dL","mmol/L","0.0259",[["0–<14 d","16.2–50.6","0.42–1.31","10"],["14 d–<1 y","10.4–51.7","0.27–1.34",""],["1–<19 y","8.88–39.0","0.23–1.01",""]],"p. 1428"]],"A1","p. 1428",206],["Retinol-binding protein (RBP)",[],[["S","mg/dL","mg/L","10",[["Birth","1.1–3.4","11–34","1"],["6 mo","1.8–5.0","18–50",""],["Adult","3.0–6.0","30–60",""]],"p. 1428"]],"A1","p. 1428",207],["Reverse triiodothyronine (rT3)",[],[["S","ng/dL","nmol/L","0.0154",[["Cord (>37 wk)","130–300","2.00–4.62","1"],["Children","","",""],["1d","83–194","1.28–2.99",""],["2d","107–209","1.65–3.22",""],["3d","102–166","1.57–2.56",""],["1 mo–20 y","10–35","0.15–0.54",""],["Adult","10–28","0.15–0.43",""],["Maternal serum (15–40 wk)","11–33","0.17–0.51",""],["Amniotic serum","","",""],["(17–22 wk)","163–599","2.51–9.22",""]],"p. 1428"]],"A1","p. 1428",208],["Rheumatoid factor (RF)",["Values (0–<19 y) based on","Abbott Architect method"],[["S","IU/mL","kIU/L","1",[["0–14 d","9.0–17.1","9.0–17.1","7"],["15 d–<19 y","9.0–9.0","9.0–9.0",""],["Adult","<7.5–14","<7.5–14","32"]],"p. 1428"]],"A1","p. 1428",209,{"sp":"S","nm":"Rheumatoid factor","n":"1","cvi":8.5,"cvg":24.5}],["Riboflavin (vitamin B2)",[],[["S","µg/dL","nmol/L","26.6",[["","4–24","106–638","1"]],"p. 1428"],["Erythrocytes","µg/dL","nmol/L","26.6",[["","10–50","266–1330",""]],"p. 1428"],["U","µg/g creatinine","µmol/mol creatinine","0.3",[["",">80",">24",""]],"p. 1428"],["U, 24 h","µg/d","nmol/d","2 .66",[["",">100",">266",""]],"p. 1428"]],"A1","p. 1428",210],["Risperidone + 9-",["hydroxyrisperidone","(Risperdal)"],[["S or P","ng/mL 2.44","nmol/L","",[["Therap","20–60","49–146",""]],"p. 1459"]],"A3","p. 1459",108],["Ritonavir (Norvir)",[],[["S or P","µg/mL 1.39","µmol/L","",[["Therap",">2",">3",""],["Toxic",">22",">31",""]],"p. 1459"]],"A3","p. 1459",109],["Salicylates as salicylic",["acid or with chronic","ingestion"],[["S or P","µg/mL 0.00727","mmol/L","",[["Therap","","",""],["Analgesia, antipyresis","<100","<0.7",""],["Anti inflammatory","150–300","1–2",""],["Toxic",">100",">0.7",""],["Lethal, 24+ h after a dose",">500",">4",""]],"p. 1459"]],"A3","p. 1459",110],["Saquinavir (Fortovase, Invirase)",[],[["S or P","µg/mL 1.49","µmol/L","",[["Therap",">0.25",">0.4",""],["Toxic",">6.0",">9",""]],"p. 1459"]],"A3","p. 1459",111],["Sebacic acid",[],[["U","","mmol/mol creatinine","",[["1–6 mo","","3–16",""],[">6 mo","","3–26",""],["","","<9",""]],"p. 1428"]],"A1","p. 1428",211],["Secobarbital (Seconal) or",[],[["P","µg/mL 4.2","µmol/L","",[["Therap","1–2","4.2–8.4",""],["Toxic",">5",">21.0",""]],"p. 1459"]],"A3","p. 1459",112],["Selenium",["Serotonin"],[["S","µg/L","µmol/L","0.0127",[["Neonates","<8.0 (deficiency)","<0.10 (deficiency)","1"],["<2 y","16–71","0.2–0.9",""]],"p. 1428"],["","Conversion","Reference","0.0127",[["2–4 y","40–103","0.5–1.3",""],["4–16 y","55–134","0.7–1.7",""],["Adults","63–160","0.8–2.0",""]],"p. 1429"],["WB (Hep)","Conversion","Reference","0.0127",[["","58–234","0.74–2.97",""]],"p. 1429"],["U, 24 h","Conversion","Reference","0.0127",[["","7–160","0.09–2.03",""],["Toxic conc",">400",">5.08",""],["*See Chapter 53,","","",""],["Table 53.15","","",""]],"p. 1429"]],"A1","pp. 1428–1429",212,{"sp":"B","nm":"Selenium","n":"1","cvi":12.0,"cvg":12.0}],["Serotonin",[],[["CSF","","nmol/L","5.68",[["1.0–2.1","","5.7– 12.0",""]],"p. 1450"]],"A2","p. 1450",17],["Sertraline (Zoloft)",[],[["S or P","ng/mL 3.27","nmol/L","",[["Therap","10–50","33–164",""],["Toxic",">300",">981",""]],"p. 1459"]],"A3","p. 1459",113],["Sex hormone–binding globulin (SHBG)",["Values (4 d–<19 y) based","on Abbott Architect","method","Tanner values based on Ab-","bott Architect method"],[["S","nmol/L","nmol/L","1",[["4 d–<1 mo","14.4–120.2","14.4–120.2","15"],["1 mo–<1 y","36.2–229.0","36.2–229.0",""],["1–<8 y","41.8–188.7","41.8–188.7",""],["8–<11 y","26.4–162.4","26.4–162.4",""],["11–<13 y","14.9–107.8","14.9–107.8",""],["13–<15 y","11.2–98.2","11.2–98.2",""],["15–<17 y, F","9.8–84.1","9.8–84.1",""],["17–<19 y, F","10.8–154.6","10.8–154.6",""],["Puberty, Tanner stage","","",""],["1, M","23.4–156.8","23.4–156.8",""],["1, F","21.1–210.1","21.1–210.1",""],["2, M","27.5–133.4","27.5–133.4",""],["2, F","29.6–140.7","29.6–140.7",""],["3, M","17.4–160.1","17.4–160.1",""],["3, F","23.7–101.7","23.7–101.7",""],["4, M","12.2–79.4","12.2–79.4",""],["4, F","12.1–125.6","12.1–125.6",""],["5, M","7.7–49.4","7.7–49.4",""],["5, F","15.3–92.5","15.3–92.5",""],["Adult","","","33"],["20 y","13.1–53.2","13.1–53.2",""],["30 y","13.5–57.4","13.5–57.4",""],["40 y","15.3–65.3","15.3–65.3",""],["50 y","18.4–75.6","18.4–75.6",""],["60 y","22.6–87.6","22.6–87.6",""],["70 y","27.8–101.0","27.8–101.0",""],["80 y","33.8–115.4","33.8–115.4",""]],"p. 1429"]],"A1","p. 1429",213,{"sp":"S","nm":"Sex hormone binding globulin (SHBG)","n":"2","cvi":13.05,"cvg":36.35}],["Sirolimus (Rapamune, Rapamycin)",[],[["WB","ng/mL 1.10","nmol/L","",[["Therap","4–20","4–22",""],["Toxic",">20",">22",""]],"p. 1459"]],"A3","p. 1459",114],["Sodium (Na)",["Values (0–3 y) based on","Siemens ADVIA method","Values (3–79 y) based on","OCD Vitros method"],[["","mEq/L","mmol/L","1.0",[["Premature cord","116–140","116–140","1"],["Premature, 48 h","128–148","128–148",""],["Newborn cord","126–166","126–166",""],["Newborn","133–146","133–146",""],["Infant","139–146","139–146",""],["0–3 y","139–146","139–146","19"],["3–5 y","135–142","135–142","27"],["6–15 y","136–143","136–143",""],["16–49 y, M","137–143","137–143",""],["F","137–142","137–142",""],["50–79 y","136–143","136–143",""]],"p. 1429"],["U, 24 h","mEq/d","mmol/d","1.0",[["M","41–115","41–115",""],["F 10–14 y","20–69","20–69",""]],"p. 1429"],["","Conversion","Reference","1.0",[["M","63–177","63–177",""],["F","48–168","48–168",""],["Adult","","",""],["M","40–220","40–220",""],["F","27–287","27–287",""]],"p. 1430"]],"A1","pp. 1429–1430",214,{"sp":"S","nm":"Sodium","n":"21","cvi":0.6,"cvg":0.7}],["Soluble transferrin receptor (STfR)",["Values based on Beckman","DxI method"],[["S","mg/L","mg/L","",[["0–<1 y","0.98–1.99","0.98–1.99",""],["1–<2.5 y","1.37–2.64","1.37–2.64","12"],["2.5–<14 y","1.03–2.09","1.03–2.09",""],["14–<19 y","0.79–1.68","0.79–1.68",""]],"pp. 1433–1434"]],"A1","pp. 1433–1434",234],["Sotalol (Betapace, Sorine)",[],[["S or P","µg/mL 3.67","µmol/L","",[["Therap","1–3","4–11",""]],"p. 1459"]],"A3","p. 1459",115],["Squamous Cell Carcinoma Antigen (SCC)",["Values based on Abbott","Architect method"],[["S","ng/mL","µg/L","1.0",[["0–<1 wk",">70",">70","4"],["1 wk–<1 y","0.6–17","0.6–17",""],["1–<19 y","0.4–1.6","0.4–1.6",""]],"p. 1430"]],"A1","p. 1430",217],["Streptomycin",[],[["S or P","µg/ml 1.72","µmol/L","",[["Therap","","",""],["Trough","<5","<9",""],["Peak","20–30","34–52",""],["Peak/MIC",">10",">17.2",""],["Toxic",">50",">86",""]],"p. 1459"]],"A3","p. 1459",116],["Suberic acid",[],[["U","","mmol/mol creatinine","",[["0–6 mo","","4–20","1"],[">6 mo","","<9",""]],"p. 1430"]],"A1","p. 1430",215],["Succinic acid",[],[["U","","mmol/mol creatinine","",[["0–1 mo","","35–547","1"],["1–6 mo","","34–156",""],["6 mo–5 y","","16–118",""],[">5y","","29–87",""]],"p. 1430"]],"A1","p. 1430",216],["Sulfonamides as sulfanilamide",[],[["S or P","mg/mL 5.81","mmol/L","",[["Therap","5–15","29–87",""],["Toxic",">20",">116",""]],"p. 1459"]],"A3","p. 1459",117],["Tacrolimus (FK 506, Prodraf)",[],[["WB","ng/mL 1.24","nmol/L","",[["Therap","3–20","4–25",""],["Toxic",">20",">25",""]],"p. 1459"]],"A3","p. 1459",118],["Teicoplanin (Targocid)",[],[["S or P","µg/mL 0.53","µmol/L","",[["Peak",">10",">5",""]],"p. 1459"]],"A3","p. 1459",119],["Testosterone, bioavailable (Vermeulen equation)",["Values (0–<19 y) based on","Abbott Architect method"],[["S","ng/dL","nmol/L","0.0347",[["0–<1 y, F","0.29–6.05","0.01–0.21","18"],["1–<9 y, F","0.29–6.05","0.01–0.21",""],["9–<14 y, F","0.58–10.95","0.02–0.38",""],["14–<19 y, F","3.75–23.05","0.13–0.80",""],["0–<1 y, M","0–121.9","0.01–4.23",""],["1–<9 y, M","0.29–2.88","0.01–0.10",""],["9–<14 y, M","0.58–161.69","0.02–5.62",""],["14–<19 y, M","12.1–346.69","0.42–12.03",""],["Adult","","",""],["M","66–417","2.29–14.5","1"],["F","0.6–5.0","0.02–0.17",""]],"p. 1430"]],"A1","p. 1430",218],["Testosterone, free (Vermeu-S len Equation)",["Values (0–<19 y) based on","Abbott Architect method"],[["","pg/mL","pmol/L","3.47",[["Cord, M","5–22","17.4–76.3","1"],["Cord, F","4–19","13.9–55.5",""],["0–<1 y, F","0.1–2.6","0.4–9.0","18"],["1–<9 y, F","0.1–2.6","0.4–9.0",""],["9–<14 y, F","0.3–4.7","1.0–16.3",""],["14–<19 y, F","1.4–9.9","4.9–34.4",""],["0–<1 y, M","0.03–57.2","0.1–198.6",""],["1–<9 y, M","0.1–1.2","0.4–4.2",""],["9–<14 y, M","0.4–72.2","1.4–250.7",""],["14–<19 y, M","5.0–142.3","17.4–494.1",""],["Adult","","",""],["M","50–210","174–729",""],["F","1.0–8.5","3.5–29.5",""]],"p. 1430"]],"A1","p. 1430",219,{"sp":"S","nm":"Testosterone, free","n":"3","cvi":9.3,"cvg":null}],["Testosterone, total",["Values (4 d–<19 y) based","on Abbott Architect","method","Tanner values based on Ab-","bott Architect method","For LC-MSMS pediatric"],[["S","ng/dL","nmol/L","0.0347",[["Cord, M","13–55","0.45–1.91","1"],["Cord, F","5–45","0.17–1.56",""],["Premature","","",""],["M","37–198","1.28–6.87",""],["F","5–22","0.17–0.76",""]],"p. 1430"],["","Conventional","nmol/L","Conversion",[["4 d–<9 y, F","1–62","0.0–2.15","15"],["9–<13 y, F","<28","<0.98",""],["13–<15 y, F","10–44","0.36–1.54",""],["15–<19 y, F","14–49","0.49–1.70",""],["4 d–<6 mo, M","9–299","0.3–10.37",""],["6 mo–<9 y, M","<36","<1.24",""],["9–<11 y, M","<23","<0.81",""],["11–<14 y, M","<444","<15.42",""],["14–<16 y, M","36–632","1.25–21.94",""],["16–<19 y, M","148–794","5.13–27.55",""],["Pubertal levels","","",""],["Tanner stage","","",""],["1, M","<18","<0.62",""],["1, F","<19","<0.67",""],["2, M","<25","<0.85",""],["2, F","<20","<0.69",""],["3, M","<543","<18.85",""],["3, F","<42","<1.45",""],["4, M","9–636","0.30–22.08",""],["4, F","9–42","0.31–1.44",""],["5, M","100–760","3.46–26.36",""],["5, F","4–50","0.13–1.72",""],["Adult","","",""],["M","260–1000","9–34.72","1"],["F","15–70","0.52–2.43",""]],"p. 1431"]],"A1","pp. 1430–1431",220,{"sp":"S","nm":"Testosterone","n":"7","cvi":9.25,"cvg":22.05}],["Tetradecanedioic acid",[],[["U","","mmol/mol creatinine","",[["","","<0.5","1"]],"p. 1431"]],"A1","p. 1431",221],["Thallium",[],[["WB (Hep)","µg/L","nmol/L","4.89",[["","<5","<24.5","1"]],"p. 1431"],["","mg/L","µmol/L","4.89",[["Toxic","0.1–8.0","0.5–390",""]],"p. 1431"],["U, 24 h","µg/L","Nmol/L","4.89",[["","<2.0","<9.8",""]],"p. 1431"],["","mg/L","µmol/L","4.89",[["Toxic","1.0–20.0","4.9–97.8",""]],"p. 1431"]],"A1","p. 1431",222],["Theophylline (Uniphyl)",[],[["S or P","µg/mL 5.55","µmol/L","",[["Bronchodilator","8–20","44–111",""],["Premature apnea","6–13","33–72",""],["Toxic",">20",">111",""]],"p. 1460"]],"A3","p. 1460",120],["Thiocyanate",[],[["S","mg/dL","µmol/L","172.4",[["Nonsmokers","<0.4","<69","1"],["Smokers","<1.2","<207",""],["Nitroprusside therapy","0.6–2.9","103–500",""],["Toxic",">5",">862",""]],"p. 1431"]],"A1","p. 1431",223],["Thiopental (Pentothal)",[],[["S or P","µg/mL 4.13","µmol/L","",[["Hypnotic","1–5","4–21",""],["Coma","30–100","124–413",""],["Anesthesia","7–130","29–536",""],["Toxic",">10",">41",""]],"p. 1460"]],"A3","p. 1460",121],["Thioridazine (Mellaril)",[],[["S or P","µg/mL 2.7","µmol/L","",[["Therap","0.2–2.0","0.5–5",""],["Toxic",">10",">27",""]],"p. 1460"]],"A3","p. 1460",122],["Threonine",[],[["P","mg/dL","µmol/L","84",[["Premature, 1 d","1.14–3.98","95–335","1"],["Newborn, 1 d","1.36–3.99","114–335",""],["1–3 mo","0.75–2.67","64–224",""],["2–6 mo","2.27–4.33","191–364",""],["3–10 y","0.50–1.13","42–95",""],["6–18 y","0.88–2.40","74–202",""],["Adult","0.94–2.30","79–193",""]],"p. 1431"],["S","mg/dL","µmol/L","84",[["0–<1 y","0.96–3.73","81–313","20"]],"p. 1431"],["","Conventional","µmol/L","Conversion",[["1–<19 y","0.86–2.20","72–185",""]],"p. 1432"],["U, 24 h","mg/d","µmol/d","8.40",[["10 d–7 wk","1.5–11.9","13–100","1"],["3–12 y","10.1–29.6","85–249",""],["Adult","14.3–46.7","120–392",""]],"p. 1432"],["","mg/g creatinine","mmol/mol creatinine","0.95",[["Adult","0–28","0–27",""]],"p. 1432"]],"A1","pp. 1431–1432",224],["Thyroglobulin (TG)",["Pediatric values (0–<19","years) based on Beckman","DxI method"],[["S","ng/mL","µg/L","1.0",[["0–<2 y, F","7.82–79.5","7.82–79.5","12"],["0–<2 y, M","2.99–56.0","2.99–56.0",""],["2–<6 y","6.74–34.2","6.74–34.2",""],["6–<9 y","5.01–28.5","5.01–28.5",""],["9–<19 y","2.50–25.8","2.50–25.8",""],["Adult euthyroid","3–42","3–42","1"],["Athyroidic patient","<5","<5",""]],"p. 1432"]],"A1","p. 1432",225,{"sp":"S","nm":"Thyroglobulin","n":"2","cvi":14.0,"cvg":39.0}],["Thyroid uptake",["Pediatric values based on","Beckman DxI method"],[["S","%","%","1.0",[["0–<12 y","38.1–49.5","38.1–49.5","12"],["12–<19 y, F","38.1–48.5","38.1–48.5",""],["12–<19 y, M","39.6–48.8","39.6–48.8",""]],"p. 1432"]],"A1","p. 1432",226],["Thyrotropin (thyroid-stimulating hormone) (TSH)",["Values (4 d–<19 y) based","on Abbott Architect","method"],[["S","µIU/mL","mIU/L","1.0",[["Premature, 28–36 0.7–27.0 wk","","0.7–27.0","1"],["Cord blood (>37 2.3–13.2 wk)","","2.3–13.2",""],["4 d–<6 mo","0.7–4.8","0.7–4.8","3"],["6 mo–<14 y","0.7–4.2","",""],["14–<19 y","0.5–3.4","0.5–3.4",""],["Adults","","","1"],["21–54 y","0.4–4.2","0.4–4.2",""],["55–87 y","0.5–8.9","0.5–8.9",""]],"p. 1432"],["","µIU/mL","mU/L","1.0",[["1st trimester","0.1–2.5","0.1–2.5","36"],["2nd trimester 0.2–3.0","","0.2–3.0",""],["3rd trimester","0.3–3.0","0.3–3.0",""]],"p. 1432"],["WB (heel","µIU/mL","mU/L","1.0",[["Newborn screen <20","","<20",""]],"p. 1432"]],"A1","p. 1432",227,{"sp":"S","nm":"Thyroid stimulating hormone (TSH)","n":"9","cvi":19.3,"cvg":24.6}],["Thyroxine (T4), total",["Values (7 d–<19 y) based","on Abbott Architect","method"],[["S","µg/dL","nmol/L","12.9",[["7 d–<1 y","5.9–13.7","76–176","3"],["1–<9 y","6.2–10.3","79–133",""],["9–<12 y","5.5–9.3","71–120",""],["12–<14 y, F","5.1–8.3","65–107",""],["12–<14 y, M","5.0–8.3","65–107",""],["14–<19 y, F Adults (15–60 y)","5.5–13.0","70–167",""],["M","4.6–10.5","59–135",""],["F","5.5–11.0","65–138",""],[">60 y","5.0–10.7","65–138",""],["Newborn screen","","",""],["1–5 d",">7.5",">97",""],["6d",">6.5",">84",""]],"p. 1433"]],"A1","p. 1433",229,{"sp":"S","nm":"Thyroxine (T4)","n":"11","cvi":4.9,"cvg":10.9}],["Thyroxine, free (FT4)",["Values (5 d–<19 y) based","on Abbott Architect","method"],[["S","ng/dL","pmol/L","12.9",[["Newborns (1–4 d) 2.2–5.3","","28.4–68.4","1"],["5–15 d","1.1–3.2","13.5–41.3","3"],["15–<30 d","0.7–2.5","8.7–32.5",""],["30 d–<1 y","0.9–1.7","11.4–21.9",""],["1–<19 y","0.9–1.4","11.4–17.6",""],["Adults (21–87 y) 0.8–2.7","","10.3–34.7","1"],["Pregnancy","","",""],["1st trimester","0.7–2.0","9.0–25.7",""],["2nd and 3rd trimesters","0.5–1.6","6.4–20.6",""]],"p. 1433"]],"A1","p. 1433",230,{"sp":"S","nm":"Thyroxine, free (FT4)","n":"5","cvi":5.7,"cvg":12.1}],["Thyroxine, free index (FT4I)",[],[["S","µg/dL","nmol/L","12 .9",[["Cord","6.0–13.2","77–170","1"],["Infants","","",""],["1–3 d","9.9–17.5","128–226",""],["1 wk","7.5–15.1","97–195",""],["1–12 mo","5.0–13.0","65–168",""],["Children","","",""],["1–10 y","5.4–12.8","70–165",""],["Pubertal child and adult","4.2–13.0","54–168",""]],"p. 1433"]],"A1","p. 1433",231],["Thyroxine-binding globulin (TBG)",[],[["S","mg/dL","mg/L","10",[["Cord","3.6–9.6","36–96","1"],["Children","","",""],["4 mo–1 y","3.1–5.6","31–56",""],["1–5 y","2.9–5.4","29–54",""],["5–10 y","2.5–5.0","25–50",""],["10–15 y","2.1–4.6","21–46",""],["Adult","","",""],["M","1.2–2.5","12–25",""],["F","1.4–3.0","14–30",""],["F (oral contraceptive)","1.5–5.5","15–55",""]],"p. 1432"]],"A1","p. 1432",228,{"sp":"S","nm":"Thyroxine binding globulin (TBG)","n":"2","cvi":0.09,"cvg":0.06}],["Tiagabine (Gabitril)",[],[["S or P","ng/mL 2.66","nmol/L","",[["Therap","20–200","53–532",""],["Toxic",">520",">1383",""]],"p. 1460"]],"A3","p. 1460",123],["Tobramycin (Nebcin)",[],[["S or P","µg/mL 2.14","µmol/L","",[["Therap","","",""],["Peak","","",""],["Less severe infection","5–8","11–17",""],["Severe infection","8–10","17–21",""],["Trough","","",""],["Less severe infection","<1","<2",""],["Moderate infection","<2","<4",""],["Severe infection","<4","<9",""],["Toxic","","",""],["Peak",">10",">21",""],["Trough",">2",">4",""],["Peak/MIC",">10",">21",""]],"p. 1460"]],"A3","p. 1460",124],["Tocainide (Tonocard)",[],[["S or P","µg/mL 5.20","µmol/L","",[["Therap","6–15","31–78",""],["Toxic",">15",">78",""]],"p. 1460"]],"A3","p. 1460",125],["Tolbutamide (Orinase)",[],[["S or P","µg/mL 3.70","µmol/L","",[["Therap","90–240","333–888",""],["Toxic",">640",">2368",""]],"p. 1460"]],"A3","p. 1460",126],["Topiramate (Topamax)",[],[["S or P","µg/mL 2.95","µmol/L","",[["Therap","5–20","15–59",""],["Toxic",">12",">36",""]],"p. 1460"]],"A3","p. 1460",127],["trans-Cinnamoylglycine",[],[["U","","mmol/mol creatinine","",[["","","0.1–8.0","1"]],"p. 1401"]],"A1","p. 1401",65],["Transferrin",["Values (0–<19 y) based on","Abbott Architect method"],[["S","mg/dL","g/L","0.01",[["0–<9 wk","104–224","1.0–2.2","7"],["9 wk–<1 y","107–324","1.1–3.2",""],["1–<19 y","220–337","2.2–3.4",""],["20–60 y","200–360","2.0–3.6","1"],[">60 y","160–340","1.6–3.4",""]],"p. 1433"]],"A1","p. 1433",232,{"sp":"S","nm":"Transferrin","n":"5","cvi":3.0,"cvg":4.3}],["Transferrin saturation",["Values based on Abbott Architect method"],[["S","%","%","1.0",[["0 –<1 y","4.1–59","4.1–59","11"],["1 –<14 y","6.5–39","6.5–39",""],["14 –<19 y, F","5.2–44","5.2–44",""],["14 –<19 y, M","9.6–58","9.6–58",""]],"p. 1433"]],"A1","p. 1433",233],["Transketolase, erythrocyte Erythrocytes",[],[["","U/g Hb","kU/mol Hb","64.53",[["","0.75–1.30","48.4–83.9","1"]],"p. 1434"]],"A1","p. 1434",235],["Transthyretin (prealbumin)",["Values (0–<19 y) based on","Abbott Architect method"],[["S","mg/dL","mg/L","10",[["0–14 d","2–12","20–120","7"],["15 d–<1 y","5–24","50–240",""],["1–<5 y","12–23","120–230",""],["5–<13 y","14–26","140–260",""],["13–<16 y","18–31","180–310",""],["16–<19 y, F","17–33","170–330",""],["16–<19 y, M","20–35","200–350",""],["Adult (20–60 y)","20–40","200–400","1"]],"p. 1434"]],"A1","p. 1434",236],["Trazodone (Desyrel)",[],[["S or P","ng/mL 2.68","nmol/L","",[["Therap","650–1500","1748–4020",""],["Toxic",">4000",">10,720",""]],"p. 1460"]],"A3","p. 1460",128],["Triglycerides",["Values (0–<6 y) based on","Abbott Architect method","Values (6–79 y) based on","OCD Vitros method"],[["S","mg/dL","mmol/L","0.0113",[["0–14 d","82–259","0.9–2.9","7"],["15 d–<1 y","53–258","0.6–2.9",""],["1–<6 y","44–197","0.5–2.2",""],["6–29 y","35–186","0.4–2.1","27"],["30–79 y M","44–301","0.5–3.4",""],["30–79 F","35–212","0.4–2.4",""]],"p. 1434"]],"A1","p. 1434",237,{"sp":"S","nm":"Triglyceride","n":"31","cvi":19.9,"cvg":32.7}],["Triiodothyronine (T3), free",["Values (4 d–<19 y) based","on Abbott Architect","method"],[["S","pg/dL","pmol/L","0.0154",[["Cord","15–391","0.2–6.0","1"],["4 d-<1 y","234–487","3.6–7.5","3"],["1–<12 y","279–442","4.3–6.8",""],["12–<15 y, F","247–396","3.8–6.1",""],["12–<15 y, M","286–435","4.4–6.7",""],["15–<19 y, F","234–370","3.6–5.7",""],["15–<19 y, M","227–383","3.5–5.9",""],["Adult","210–440","3.2–6.8","1"]],"p. 1434"],["","Conversion","pmol/L","0.0154",[["Pregnancy","200–380","3.1–5.9",""]],"p. 1435"]],"A1","pp. 1434–1435",239,{"sp":"S","nm":"Triiodothyronine, free (FT3)","n":"4","cvi":7.9,"cvg":17.6}],["Triiodothyronine (T3), total",["Values (4 d–<19 y) based","on Abbott Architect","method"],[["S","ng/dL","nmol/L","0.0154",[["Cord (>37 wk)","5–141","0.08–2.17","1"],["4 d–<1 y","85–234","1.33–3.60","3"],["1–<12 y","113–189","1.74–2.91",""],["12–<15 y","98–176","1.50–2.71",""],["15–<17 y, F","92–142","1.42–2.18",""],["15–<17 y, M","94–156","1.44–2.40",""],["17–<19 y","90–168","1.38–2.58",""],["Adults","","","1"],["20–50 y","70–204","1.08–3.14",""],["50–90 y","40–181","0.62–2.79",""],["Pregnancy","","",""],["1st trimester","81–190","1.25–2.93",""],["2nd and 3rd trimesters","100–260","1.54–4.00",""]],"p. 1435"]],"A1","p. 1435",240,{"sp":"S","nm":"Triiodothyronine (T3)","n":"10","cvi":6.9,"cvg":12.3}],["Trimipramine (Surmontil)",[],[["S or P","ng/mL 3.40","nmol/L","",[["Therap","150–350","510–1190",""],["Toxic",">500",">1700",""]],"p. 1460"]],"A3","p. 1460",129],["Troponin I, high sensitivity",["Values based on Abbott Ar-","chitect method, 99th per-","centile"],[["S","ng/L","ng/L","1",[["0–<19 y","< 33.6","< 33.6","13"]],"p. 1435"]],"A1","p. 1435",241,{"sp":"S","nm":"Troponin I","n":"5","cvi":14.05,"cvg":63.75}],["Troponin T, high sensitivity",["Values based on Roche","cobas method, 99th","percentile"],[["S","ng/L","ng/L","1",[["0–<6 mo","<93","<93","5"],["6 mo–<1 y","<21","<21",""],["1–<19 y, F","<11","<11",""],["1– <19 y, M","<14","<14",""]],"p. 1435"]],"A1","p. 1435",242,{"sp":"S","nm":"Troponin T","n":"1","cvi":30.5,"cvg":90.0}],["Tryptophan",[],[["P","mg/dL","µmol/L","49",[["Premature, 1 d","0–1.23","0–60","1"],["Newborn, 1 d","<1.37","<67",""],["1–16 y","0.49–1.61","24–79",""],[">16 y","0.41–1.94","20–95",""]],"p. 1435"],["U, 24 h","mg/d","µmol/d","4.9",[["Adult","5–39","25–191",""]],"p. 1435"],["","mg/g","mmol/mol","4.9",[["Adult","<30","<16.5",""]],"p. 1435"]],"A1","p. 1435",243,{"sp":"P","nm":"Tryptophan","n":"1","cvi":22.7,"cvg":152.6}],["Tumor-associated trypsin inhibitor (TATI)",[],[["S","ng/mL","µg/L","1.0",[["","3–21","3–21","1"]],"p. 1435"],["U","ng/mL","µg/L","1.0",[["","7–51","7–51",""]],"p. 1435"]],"A1","p. 1435",244],["Tyrosine",[],[["P","mg/dL","mmol/L","55.2",[["Premature, 1 d","0–5.79","0–320","1"],["Newborn, 1 d","0.76–1.79","42–99",""],["1–3 mo","0.54–2.42","30–134",""],["2–6 mo","1.30–3.91","72–216",""],["9 mo-2 y","0.20–2.21","1–122",""],["3–10 y","0.56–1.29","31–71",""],["6–18 y","0.78–1.59","43–88",""],["Adult","0.40–1.58","22–87",""]],"p. 1435"],["S","mg/dL","mmol/L","55.2",[["0–<2 wk","0.49–3.39","27–187","20"],["2 wk–<1 y","0.62–2.74","34–151",""],["1–<13 y","0.82–2.28","45–126",""],["13–<19 y","0.62–1.59","34–88",""]],"p. 1435"],["U, 24 h","mg/d","µmol/d","5.52",[["10 d–7 wk","4.0–7.2","22–40","1"]],"p. 1435"],["","Conversion","Reference","5.52",[["3–12 y","7.2–30.4","40–168",""],["Adult","12.0–55.1","66–304",""]],"p. 1436"],["","mg/g creatinine","mmol/mol creatinine","0.62",[["Adult","0–23","0–14.2",""]],"p. 1436"]],"A1","pp. 1435–1436",245],["Uracil",[],[["U","","mmol/mol creatinine","",[["0–6 mo","","<33",""],["6 mo–5 y","","<22",""],[">5 y","","<18",""]],"p. 1436"]],"A1","p. 1436",246],["Urea",["Values (0–<3 y) based on","Abbott Architect method","Values (3–79) based on","OCD Vitros method"],[["S","mg/dL","mmol/L","0.357",[["0–<14 d","3–23","1.0–8.2","7"],["15 d–<1 y","3–17","1.2–6.0",""],["1–<3 y","9–22","3.2–7.9",""],["3–5 y","9–19","3.1–6.9","27"],["6–7 y","8–21","2.8–7.5",""],["8–19 y, M","8–20","2.9–7.0",""],["20–39 y, M","9–22","3.3–7.9",""],["40–59 y, M","10–24","3.5–8.6",""],["8–59 y, F","8–19","2.7–6.7",""],["60–79 y","10–26","3.6–9.2",""]],"p. 1436"],["U, 24 h","g/d","mol/d","0.0357",[["","10–20","0.43–0.71","1"]],"p. 1436"]],"A1","p. 1436",247,{"sp":"S","nm":"Urea","n":"20","cvi":12.1,"cvg":18.7}],["Urea Creatinine Ratio (UCR)S",["Values based on Abbott","Architect method,","Enzymatic","Values based on Abbott","Architect method, Jaffe"],[["","mg/dL/mg/dL","µmol/L/ µmol/L","4.04",[["0–<15 d","5–40","21–162","6"],["15 d–<1 y","12–108","49–438",""],["1–<3 y","31–104","127–419",""],["3–<5 y","32–74","130–299",""],["5–<8 y","22–61","87–246",""],["8–<10 y, F","17–44","69–177",""],["8–<10 y, M","21–47","83–189",""],["10–<15 y","12–36","50–146",""],["15–<19 y","11–26","44–107",""],["0–<15 d","6–30","26–121",""],["15 d–<1 y","9–39","35–156",""],["1–<5 y","17–49","70–198",""],["5–<8 y","17–40","69–160",""],["8–<10 y, F","14–32","57–131",""],["8–<10 y, M","16–39","66–156",""],["10–<15 y, F","10–27","42–111",""],["10–<15 y, M","12–33","50–134",""],["15–<19 y","10–25","42–99",""]],"p. 1436"]],"A1","p. 1436",248],["Uric acid",["Values (0–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","OCD Vitros method"],[["S","mg/dL","µmol/L","59.48",[["0–14 d","2.8–12.7","167–755","7"],["15 d–<1 y","1.6–6.3","95–375",""],["1–<3 y","1.8–4.9","107–291",""],["3–<5 y","2.0–4.9","117–291","27"],["5–8 y","1.9–5.0","116–295",""],["9–10 y","2.4–5.5","142–326",""],["11–12 y","2.6–5.8","156–345",""],["13–79 y, M","3.7–7.7","218–459",""],["F","2.5–6.2","147–366",""]],"p. 1436"]],"A1","p. 1436",249,{"sp":"S","nm":"Urate","n":"16","cvi":8.6,"cvg":17.5}],["Valine",["Vanillylmandelic acid U,","(VMA)"],[["P","mg/dL","µmol/L","85.5",[["Premature, 1 d","0.34–2.70","30–230","1"],["Newborn, 1 d","0.94–2.88","80–246",""],["1–3 mo","1.13–3.41","96–292",""]],"p. 1436"],["","Conventional","µmol/L","Conversion",[["9 mo–2 y","0.67–3.07","57–262",""],["3–10 y","1.50–3.31","128–283",""],["6–18 y","1.83–3.37","156–288",""],["Adult","1.65–3.71","141–317",""]],"p. 1437"],["S","Conventional","µmol/L","Conversion",[["0–<2 wk","1.02–3.81","87–326","20"],["2 wk–<13 y","1.50–4.22","128–361",""],["13–<19 y, F","1.81–3.03","155–259",""],["13–<19 y, M","1.94–3.52","166–301",""]],"p. 1437"],["U, 24 h","mg/d","µmol/d","8.55",[["10 d–7 wk","1.4–3.2","12–27","1"],["3–12 y","1.8–6.0","15–51",""],["Adult","2.5–11.9","21–102",""]],"p. 1437"],["24 h","mg/d","µmol/d","8.55",[["*See Chapter 53,","","",""],["Table 53.5","","",""]],"p. 1437"]],"A1","pp. 1436–1437",250,{"sp":"P","nm":"Valine","n":"1","cvi":10.6,"cvg":40.1}],["Valproic acid (Depakene)",[],[["S or P","µg/mL 6.93","µmol/L","",[["Therap","50–100","346–693",""],["Toxic",">100",">693",""]],"p. 1460"]],"A3","p. 1460",130],["Vancomycin (Vancocin) or",[],[["P","µg/mL","µmol/L","0.69",[["Therap","","",""],["Peak","20–40","14–28",""],["Trough",">10",">7",""],["Toxic",">80",">55",""]],"p. 1461"]],"A3","p. 1461",131],["Vasopressin (Antidiuretic hormone, ADH)",["hormone [ADH])"],[["P, EDTA","ng/L","pmol/L","0.926",[["270–280","<1.5","<1.4","1"],["280–285","<2.5","<2.3",""],["285–290","1–5","0.9–4.6",""],["290–294","2–7","1.9–6.5",""],["295–300","4–12","3.7–11.1",""]],"p. 1395"]],"A1","p. 1395",21],["Venlafaxine (Effexor) + desmethylvenlafaxine",[],[["or P","ng/mL","nmol/L","3.61",[["Therap","195–400","704–1444",""]],"p. 1461"]],"A3","p. 1461",132],["Vigabatrin (Sabril)",[],[["S or P","µg/mL","µmol/L","7.74",[["Therap","0.8–36","6–279",""]],"p. 1461"]],"A3","p. 1461",133],["Vitamin A",["Values (0–<19 y) based on","Abbott Architect method","Vitamin B1 (thiamine","diphosphate)","Vitamin B2 (see riboflavin)"],[["S","µg/dL","µmol/L","0.0349",[["0–<1 y","8–54","0.3–1.9","17"],["1–<11 y","28–44","1.0–1.6",""],["11–<16 y","25–55","0.9–1.9",""],["16–<19 y","29–75","1.0–2.6",""],["Adult","30–80","1.05–2.8","1"]],"p. 1437"],["WB","µg/dL","µmol/L","0.0349",[["","90–140 nmol/L","90–140 nmol/L",""]],"p. 1437"],["Erythrocytes","µg/dL","µmol/L","0.0349",[["","280–590 ng/g Hb","40.3–85.0 µmol/mol","1"]],"p. 1437"]],"A1","p. 1437",251],["Vitamin B12 Reference Intervals",["Values (5 d–< 3 y) based","on Abbott Architect","method","Values (3–79 y) based on","Siemens Immulite","method"],[["","ng/L","pmol/L","0.733",[["5 d–<1 y","259–1576","191–1163",""],["1–<3 y","283–1613","209–1190",""],["3–5 y","310–988","229–729","28"],["6–8 y","321–985","237–727",""],["9–11 y","276–969","204–715",""],["12–79 y","188–908","139–670",""],["Acceptable (WHO) >201","",">147","1"],["Deficiency (WHO) <150","","<110",""]],"p. 1437"]],"A1","p. 1437",253],["Vitamin B6",[],[["P (EDTA)","ng/mL","nmol/L","4.046",[["","5–30","20–121","1"],["Deficiency","<5","<20.2",""]],"p. 1437"]],"A1","p. 1437",252],["Vitamin C (ascorbic acid)",[],[["S","","µmol/L","",[["0.4–1.5","","23–85","1"],["Deficiency","<0.2","<11",""]],"p. 1437"]],"A1","p. 1437",254],["Vitamin D (1,25(OH))",["Pediatric values based on","DiaSorin LIAISON method"],[["S","pg/mL","pmol/L","2.4",[["0–<1 y","32.1–196","77–471","9"],["1–<3 y","47.1–151","113–363",""],["3–<19 y","45.0–102","108–246",""],["Adult","15–60","36–144","1"]],"p. 1438"]],"A1","p. 1438",256],["Vitamin D 25(OH)D",["Values (5 d–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","DiaSorin LIAISON method P"],[["","Conventional","nmol/L","Conversion",[["5–<15 d","2–34","4–85","3"],["15 d–<3 mo","6–41","15–101",""],["3 mo–<1 y","7–47","17–118",""],["1–<3 y","13–55","33–137",""],["3–5 y","13–42","33–104",""],["6–79 y","8–46","21–116",""],["Deficiency","<20","<50","39"]],"p. 1438"]],"A1","p. 1438",255],["Vitamin E",["Values (0–<19 y) based on","Abbott Architect method","Vitamin E: Total cholesterol","ratio","Vitamin E: Triglyceride ratio"],[["S","mg/dL","µmol/L","23.2",[["Premature neonates","0.1–0.5","2.3–11.6","1"],["0–<1 y","0.2–2.1","4.9–49.6","17"],["1–<19 y","0.6–1.4","14.5–33.0",""],["Adults","0.5–1.8","12–42","1"],["1–19 y","","3.7–6.7","17"],["1–19 y","","8.5–44.5",""]],"p. 1438"]],"A1","p. 1438",257],["Vitamin K",[],[["S","ng/mL","nmol/L","2.22",[["","0.13–1.19","0.29–2.64","1"]],"p. 1438"]],"A1","p. 1438",258],["Voriconazole (Vfend)",[],[["S or P","µg/mL","µmol/L","2.86",[["Therap","1–6","3–17",""],["Toxic",">6",">17",""]],"p. 1461"]],"A3","p. 1461",134],["Warfarin (Coumadin)",[],[["S or P","µg/mL","µmol/L","3.24",[["Therap","1–10","3–32",""],["Toxic",">10",">32",""]],"p. 1461"]],"A3","p. 1461",135],["White blood cell count",[],[["Sysmex XN-3000","103/µl","109/L","1",[["0–2 y","5.75–13.5","5.75–13.5","29, 42, 53"],["3–4 y","4.92–11.8","4.92–11.8","29, 42, 53"],["5–20 y","4.23–9.99","4.23–9.99","29, 42, 53"]],"p. 1465"],["Beckman Coulter DxH 900","103/µl","109/L","1",[["0–2 y","5.3–13.2","5.3–13.2","29, 42, 53"],["3–4 y","4.8–11.5","4.8–11.5","29, 42, 53"],["5–20 y","4.2–10.2","4.2–10.2","29, 42, 53"]],"p. 1465"],["Beckman Coulter HmX","103/µl","109/L","1",[["3–5 y","4.4–12.9","4.4–12.9","29, 42, 53"],["6–79 y","3.8–10.4","3.8–10.4","29, 42, 53"]],"p. 1465"]],"A4","p. 1465",16,{"sp":"B","nm":"Leukocytes count","n":"8","cvi":11.4,"cvg":21.3}],["ylprocainamide (NAPA)",[],[["","12–18 (NAPA)","","3.61",[["Toxic",">12",">51",""]],"p. 1458"]],"A3","p. 1458",101],["Zidovudine (AZT, Retrovir)",[],[["S or P","µg/mL","µmol/L","3.74",[["Therap",">0.2",">0.8",""]],"p. 1461"]],"A3","p. 1461",136],["Zinc",[],[["S","µg/dL","µmol/L","0.153",[["","80–120","12–18","1"],["Deficiency","<30","<5",""]],"p. 1438"],["U, 24 h","mg/24 h","µmol/24 h","15.3",[["","0.2–1.3","3–21",""]],"p. 1438"]],"A1","p. 1438",259,{"sp":"S","nm":"Zinc","n":"1","cvi":9.3,"cvg":9.4}],["Zonisamide (Zonegran) or",[],[["P","µg/mL","µmol/L","4.71",[["Therap","10–40","47–188","1"],["Potential adverse effects",">80",">377","56"]],"p. 1461"]],"A3","p. 1461",137],["α-Fetoprotein",["(AFP)"],[["Amf","ng/mL","µg/L","1",[["14","25.6","25.6",""],["15","29.9","29.9",""],["16","34.8","34.8",""],["17","40.6","40.6",""],["18","47.3","47.3",""],["19","55.1","55.1",""],["20","64.3","64.3",""],["21","74.9","74.9",""]],"p. 1449"]],"A2","p. 1449",1,{"sp":"S","nm":"α-Fetoprotein (non hepatic carcinoma)","n":"2","cvi":12.2,"cvg":45.6}],["α-Fetoprotein (AFP)",["Pediatric values based on"],[["S","","g/L","0.01",[["Fetal, 1st trimester 200–400","","2.0–4.0","1"],["Cord blood","<5","<0.05",""]],"p. 1408"],["","","µg/L","1",[["0–<1 mo",">2000",">2000","4"],["1–<3 mo","9.80–1359.0","9.80–1359.0",""],["3–<6 mo","4.15–274.70","4.15–274.70","3"],["6 mo–<1 y","2.66–148.21","2.66–148.21",""],["1–<3 y","2.88–20.94","2.88–20.94",""],["3–<19 y","0.89–4.48","0.89–4.48",""],["Adult (85% of population)","<8.5","<8.5","1"],["Adult (100% of population)","<15","<15",""]],"p. 1408"],["Maternal","(median)","µg/L (median)","1",[["Pregnancy, wk of gestation","","",""],["14 wk","25.6","25.6",""],["15 wk","29.9","29.9",""],["16 wk","34.8","34.8",""],["17 wk","40.6","40.6",""]],"p. 1408"],["","Conversion","µg/L (median)","1",[["18 wk","47.3","47.3",""],["19 wk","55.1","55.1",""],["20 wk","64.3","64.3",""],["21 wk","74.9","74.9",""]],"p. 1409"],["","ng/mL","µg/L","1",[["Early marker","10–20","10–20",""],["Cancer",">1000",">1000",""]],"p. 1409"],["Amf","ng/mL","µg/L","1",[["See Table 82.2","","",""]],"p. 1409"]],"A1","pp. 1408–1409",98,{"sp":"S","nm":"α-Fetoprotein (non hepatic carcinoma)","n":"2","cvi":12.2,"cvg":45.6}],["α1-Acid glycoprotein",["Pediatric values (0–19 y)","based on Abbott","Architect method"],[["S","mg/dL","g/L","0.01",[["0–<6 mo","21–85","0.2–0.9","14"],["6 mo–<5 y","48–201","0.5–2.0",""],["5–<19 y","48–114","0.5–1.1",""],["Adult (20–60 y)","50–120","0.5–1.2",""]],"p. 1392"]],"A1","p. 1392",3,{"sp":"S","nm":"α1-Acid Glycoprotein","n":"3","cvi":11.3,"cvg":24.9}],["α1-Antitrypsin",["Values (0–<19 y) based on","Abbott Architect method"],[["S","mg/dL","g/L","0.01",[["0–<19 y","110–181","1.1–1.8","14"],["Adult (20–60 y)","90–200","0.9–2.0","1"]],"p. 1395"]],"A1","p. 1395",25,{"sp":"S","nm":"α1-Antitrypsin","n":"3","cvi":5.9,"cvg":16.3}],["α2-Macroglobulin",[],[["S","","g/L","0.01",[["Adult (20–60 y) 130–300","","1.3–3.0","1"]],"p. 1420"]],"A1","p. 1420",157,{"sp":"S","nm":"α2-Macroglobulin","n":"4","cvi":3.4,"cvg":18.7}],["β-Carotene HPLC",[],[["S","µg/dL","µmol/L","0.0186",[["","10–85","0.19–1.58","1"]],"p. 1398"]],"A1","p. 1398",41],["β2-Microglobulin",["Values (0–<19 y) based on","Abbott Architect method"],[["S","mg/dL","mg/L","10",[["0–<3 mo, F","0.19–0.58","1.9–5.8","1"],["0–<3 mo, M","0.19–0.47","1.9–4.7",""],["3 mo–<2 y","0.13–0.45","1.3–4.5",""],["2–<19 y","0.12–0.23","1.2–2.3",""]],"p. 1421"],["","mg/dL (mean)","mg/L (mean)","10",[["0–59 y","0.19","1.9",""],["60–69 y","0.21","2.1",""],[">70 y","0.24","2.4",""]],"p. 1421"]],"A1","p. 1421",168],["γ-Glutamyltransferase",["Values (0–<3 y) based on","Abbott Architect method","Values (3–79 y) based on","OCD Vitros method"],[["S","U/L","µkat/L","0.017",[["0–<14 d","23–219","0.38–3.65","7"],["15 d–<1 y","8–127","0.13–2.12",""],["1–<3 y","6–16","0.10–0.27",""],["3–5 y","11–20","0.19–0.34","27"],["6–14 y, M","10–26","0.17–0.44",""],["6–17 y, F","9–24","0.15–0.41",""],["15–19 y, M","10–33","0.17–0.56",""],["18–35 y, F","12–38","0.20–0.65",""],["20–35 y, M","12–62","0.20–1.05",""],["36–79 y, M","13–109","0.22–1.85",""],["36–79 y, F","10–54","0.17–0.92",""]],"p. 1411"]],"A1","p. 1411",109,{"sp":"S","nm":"γ-glutamyltransferase (GGT)","n":"10","cvi":13.4,"cvg":42.15}]],"c":[["Albumin (children)","g/dL","g/L","1.7","6.8","17","68","1","p. 1465"],["Aminotransferases","U/L","µkat/L","—","1000","—","16.7","43","p. 1465"],["Ammonia","µg/dL","µmol/L","—","187","—","110","1, 43, 44","p. 1465"],["Anion gap","","mmol/L","","","—","20","43","p. 1465"],["Bilirubin (newborn)","mg/dL","mmol/L","—","15","—","257","1, 43","p. 1465"],["Calcium (total)","mg/dL","mmol/L","6.6","14","1.65","3.5","43, 44, 45","p. 1465"],["Calcium (children)","mg/dL","mmol/L","6.5","12.7","1.63","3.18","1","p. 1465"],["Calcium (free)","mg/dL","mmol/L","3.1","6.3","0.78","1.6","1, 43, 44, 45","p. 1465"],["Carbon dioxide, total","","mmol/L","","","10","40","1","p. 1465"],["Chloride (adult)","","mmol/L","","","80","120","1","p. 1465"],["Creatinine (adult)","mg/dL","mmol/L","—","5","—","442","1","p. 1465"],["Creatinine (children)","mg/dL","µmol/L","—","3.8","—","336","1","p. 1465"],["Creatine kinase","U/L","µkat/L","—","1000","—","16.7","43","p. 1465"],["Glucose","mg/dL","mmol/L","40","500","2.22","27.8","44","p. 1465"],["Glucose (children)","mg/dL","mmol/L","46","445","2.56","24.72","1","p. 1465"],["Glucose (newborn)","mg/dL","mmol/L","30","325","1.67","18.06","1,43","p. 1465"],["Glucose, CSF (adult)","mg/dL","mmol/L","40","200","2.22","11.11","1","p. 1465"],["Glucose, CSF (children)","mg/dL","mmol/L","31","—","1.72","—","1","p. 1465"],["Lactate CSF","mg/dL","mmol/L","—","30.6","—","3.4","1","p. 1466"],["Lactate plasma","mg/dL","mmol/L","—","45","—","5","43","p. 1466"],["Lactate plasma (children)","mg/dL","mmol/L","—","36.9","—","4.1","1","p. 1466"],["Lactate dehydrogenase","U/L","µkat/L","—","1000","—","16.7","43","p. 1466"],["Lipase","U/L","µkat/L","—","700","—","11.7","43","p. 1466"],["Magnesium","mg/dL","mmol/L","1","4.9","0.41","2","1, 43","p. 1466"],["Osmolality","","mOsm/kg","","","240","330","43","p. 1466"],["Osmolar gap","","mOsm/Kg","","","—","10","43","p. 1466"],["Phosphate","mg/dL","mmol/L","1","9","0.32","2.9","1, 43","p. 1466"],["Potassium","","mmol/L","","","2.8","6.2","1, 43","p. 1466"],["Potassium (newborn)","","mmol/L","","","2.8","7.8","1","p. 1466"],["Protein (children)","g/dL","g/L","3.4","9.5","34","95","1","p. 1466"],["Protein, CSF (children)","mg/dL","mg/L","—","188","—","1880","1","p. 1466"],["Sodium","","mmol/L","","","120","160","1, 43, 44, 45","p. 1466"],["T4 (free)","ng/dL","pmol/L","—","3.5","—","45","43","p. 1466"],["Urea nitrogen","mg/dL","mmol/L","—","100","—","35.6","43","p. 1466"],["Urea","mg/dL","mmol/L","—","214","—","35.6","43","p. 1466"],["Urea nitrogen (children)","mg/dL","mmol/L","—","55","—","19.6","1","p. 1466"],["Uric acid","mg/dL","mmol/L","—","13","—","0.767","1, 43","p. 1466"],["Uric acid (children)","mg/dL","","—","12","—","0.708","1","p. 1466"],["pH","","","7.2","7.6","7.2","7.6","1, 43","p. 1466"],["PCO2","mm Hg","kPa","20","70","2.7","9.45","1","p. 1466"],["PO2","mm Hg","kPa","40","—","5.3","—","1","p. 1466"],["PO2 children","mm Hg","kPa","45","125","6.0","16.7","1","p. 1466"],["PO2 newborn","mm Hg","kPa","35","90","4.7","12.0","1","p. 1466"],["Hematocrit (adult)","%","","20","60","0.20","0.60","1","p. 1466"],["Hematocrit (newborn)","%","L/L","33","71","0.33","0.71","1","p. 1466"],["emoglobin (adult)","g/dL","g/L","7.020","","70","200","1","p. 1467"],["emoglobin (newborn)","g/dL","g/L","10.022","","100","2204","1","p. 1467"],["eukocytes (adult)","103/mL","109/L","230","","2","30","1","p. 1467"],["eukocytes (children)","103/mL","109/L","243","","2","43","1","p. 1467"],["eutrophil count","103/mL","109/L","0.5 —","","0.5","—","44","p. 1467"],["latelet count","103/mL","109/L","201000","","20","1000","44, 47","p. 1467"],["rothrombin time (INR)","","","—","5","","","44, 45, 47, 48","p. 1467"],["PTT","Seconds","Seconds","—","110","—","110","47","p. 1467"],["ntithrombin","%","","28","—","—","","46","p. 1467"],["in emergency management [e.g.","","","—","5","","","","p. 1467"],["in emergency management [e.g.,","","","—","3","","","","p. 1467"],["ibrinogen","mg/dL","g/L","80 —","","0.8","—","1, 47, 48","p. 1467"],["igoxin","ng/mL","nmol/L","— 2.2","","—","2.8","44","p. 1467"],["igitoxin","mg/L","nmol/L","— 40","","—","52","43","p. 1467"],["SF","","","— 3.5","","—","66","43","p. 1467"],["BC (0–1 y)","","","— >30","","","","1","p. 1467"],["BC (1–4 y)","","","— >20","","","","","p. 1467"],["BC (5–17 y)","","","— >10","","","","","p. 1467"],["BC (>17 y)","","","— >5","","","","","p. 1467"]]}; | |
| const TABLECODE = {A1:"Table A.1", A2:"Table A.2", A3:"Table A.3", A4:"Table A.4"}; | |
| const SRCLABEL = {A1:"Serum / Plasma / Urine", A2:"Other Body Fluids", A3:"Drugs & Toxicology", A4:"Hematology"}; | |
| const SRCSHORT = {A1:"Serum / Plasma / Urine", A2:"Body Fluids", A3:"Drugs", A4:"Hematology"}; | |
| /* ---------- parsing ---------- */ | |
| const NUM = "[\u2212-]?\\d+(?:\\.\\d+)?"; | |
| function parseRange(x){ | |
| if(!x) return null; | |
| const s = String(x).replace(/\u2212/g,"-").replace(/,/g,"").trim(); | |
| let m = s.match(new RegExp("^[<\u2264]\\s*("+NUM+")$")); if(m) return {lo:null,hi:+m[1],t:"<"}; | |
| m = s.match(new RegExp("^[>\u2265]\\s*("+NUM+")$")); if(m) return {lo:+m[1],hi:null,t:">"}; | |
| m = s.match(new RegExp("^("+NUM+")\\s*[\u2013-]\\s*("+NUM+")$")); if(m) return {lo:+m[1],hi:+m[2],t:"r"}; | |
| m = s.match(new RegExp("^("+NUM+")$")); if(m) return {lo:+m[1],hi:+m[1],t:"p"}; | |
| return null; | |
| } | |
| const AGEU = {d:1/365.25, wk:7/365.25, mo:1/12, y:1, h:1/8766}; | |
| function parseAge(c){ | |
| const o = {a0:null,a1:null,sex:null}; | |
| if(!c) return o; | |
| const s = c.trim(), low = s.toLowerCase(); | |
| let m = s.match(/[,( ]\s*([MF])\b/) || s.match(/^([MF])$/); if(m) o.sex = m[1]; | |
| if(/female/i.test(s)) o.sex="F"; else if(/\bmale\b/i.test(s)) o.sex="M"; | |
| if(/cord|premature|preterm/.test(low)) return o; | |
| if(/newborn|neonate|birth/.test(low)){o.a0=0;o.a1=1/12;return o;} | |
| const tok = "("+NUM+")\\s*(d|wk|mo|y|h)?"; | |
| m = s.match(new RegExp(tok+"\\s*[\u2013-]\\s*[<\u2264]?\\s*"+tok)); | |
| if(m){const u2=m[4]||m[2]||"y", u1=m[2]||u2; o.a0=+m[1]*(AGEU[u1]||1); o.a1=+m[3]*(AGEU[u2]||1); return o;} | |
| m = s.match(new RegExp("[<\u2264]\\s*"+tok)); if(m){o.a0=0;o.a1=+m[1]*(AGEU[m[2]||"y"]||1);return o;} | |
| m = s.match(new RegExp("[>\u2265]\\s*"+tok)); if(m){o.a0=+m[1]*(AGEU[m[2]||"y"]||1);o.a1=120;return o;} | |
| if(/adult/.test(low)){o.a0=18;o.a1=120;return o;} | |
| if(/child|pediatric/.test(low)){o.a0=1;o.a1=18;return o;} | |
| if(/infant/.test(low)){o.a0=0;o.a1=1;return o;} | |
| return o; | |
| } | |
| function fmt(v){ | |
| if(v===null||v===undefined||!isFinite(v)) return "\u2014"; | |
| const a=Math.abs(v); | |
| if(a===0) return "0"; | |
| if(a>=1000) return v.toFixed(0); | |
| if(a>=100) return v.toFixed(1); | |
| if(a>=1) return v.toFixed(2); | |
| if(a>=0.01) return v.toFixed(3); | |
| return v.toPrecision(3); | |
| } | |
| function rangeText(r,u){ | |
| if(!r) return "\u2014"; | |
| u = u? " "+u : ""; | |
| if(r.t==="<") return "< "+fmt(r.hi)+u; | |
| if(r.t===">") return "> "+fmt(r.lo)+u; | |
| if(r.t==="p") return fmt(r.lo)+u; | |
| return fmt(r.lo)+" \u2013 "+fmt(r.hi)+u; | |
| } | |
| const scaleR=(r,f)=> r? {lo:r.lo===null?null:r.lo*f, hi:r.hi===null?null:r.hi*f, t:r.t} : null; | |
| function verdict(v,r){ | |
| if(!r||v===null||!isFinite(v)) return null; | |
| if(r.lo!==null && v<r.lo) return "low"; | |
| if(r.hi!==null && v>r.hi) return "high"; | |
| return "in"; | |
| } | |
| const esc = s => String(s==null?"":s).replace(/[&<>"]/g, c=>({"&":"&","<":"<",">":">",'"':"""}[c])); | |
| /* ---------- shape data ---------- */ | |
| const ITEMS = DB.a.map((e,i)=>({ | |
| id:i, name:e[0], notes:e[1], src:e[3], page:e[4], serial:e[5], bv:e[6]||null, | |
| blocks: e[2].map(b=>({ | |
| sp:b[0], cu:b[1], su:b[2], f:b[3], fnum:parseFloat(b[3]), page:b[5], | |
| rows: b[4].map(r=>{ | |
| const ag=parseAge(r[0]); | |
| return {cond:r[0], cvS:r[1], siS:r[2], ref:r[3], cv:parseRange(r[1]), si:parseRange(r[2]), a0:ag.a0, a1:ag.a1, sex:ag.sex}; | |
| }) | |
| })) | |
| })); | |
| const CRIT = DB.c.map(c=>({name:c[0],cu:c[1],su:c[2],lo:c[3],hi:c[4],loSI:c[5],hiSI:c[6],ref:c[7],page:c[8]})); | |
| const normName = s => s.toLowerCase().replace(/\(.*?\)/g,"").replace(/[^a-z ]/g,"").trim(); | |
| function critFor(name){ | |
| const n = normName(name); | |
| return CRIT.filter(c=>{ | |
| const m=normName(c.name); | |
| if(!m||!n) return false; | |
| return n===m || (m.length>=5 && n.startsWith(m)) || (n.length>=5 && m.startsWith(n)); | |
| }); | |
| } | |
| document.getElementById("counts").textContent = ITEMS.length+" analytes \u00b7 "+ | |
| ITEMS.reduce((a,e)=>a+e.blocks.reduce((n,b)=>n+b.rows.length,0),0)+" partitions \u00b7 "+CRIT.length+" critical values"; | |
| /* ---------- state ---------- */ | |
| const S = {tab:"check", sel:null, bi:0, age:"", ageU:"y", sex:"any", val:"", unitMode:"cu", useSI:false, q:"", open:false, srcFilter:"all", critQ:""}; | |
| /* ---------- svg builders ---------- */ | |
| function rail(r,val,unit){ | |
| if(!r) return ""; | |
| const lo = r.lo===null?0:r.lo; | |
| let hi = r.hi===null? (isFinite(val)&&val!==null? Math.max(val*1.2, lo*2||1) : (lo*2||1)) : r.hi; | |
| const span = (hi-lo) || Math.abs(hi) || 1; | |
| let min = lo-span*0.9, max = hi+span*0.9; | |
| if(val!==null&&isFinite(val)){min=Math.min(min,val-span*0.25);max=Math.max(max,val+span*0.25);} | |
| const W=620,H=64,P=26, x=v=>P+((v-min)/((max-min)||1))*(W-2*P); | |
| const v = verdict(val,r); | |
| const col = v==="in"?"var(--ok)":v==="low"?"var(--low)":v==="high"?"var(--high)":"var(--accent)"; | |
| let s = `<svg viewBox="0 0 ${W} ${H}">`; | |
| s += `<line x1="${P}" y1="36" x2="${W-P}" y2="36" stroke="var(--rule)" stroke-width="2"/>`; | |
| s += `<rect x="${x(lo)}" y="28" width="${Math.max(2,x(hi)-x(lo))}" height="16" rx="3" fill="var(--accentSoft)" stroke="var(--accent)"/>`; | |
| if(r.lo!==null) s += `<text x="${x(lo)}" y="60" font-family="var(--mono)" font-size="10" fill="var(--sub)" text-anchor="middle">${fmt(r.lo)}</text>`; | |
| if(r.hi!==null) s += `<text x="${x(hi)}" y="60" font-family="var(--mono)" font-size="10" fill="var(--sub)" text-anchor="middle">${fmt(r.hi)}</text>`; | |
| if(val!==null&&isFinite(val)){ | |
| s += `<line x1="${x(val)}" y1="14" x2="${x(val)}" y2="48" stroke="${col}" stroke-width="2.5"/>`; | |
| s += `<circle cx="${x(val)}" cy="14" r="4" fill="${col}"/>`; | |
| s += `<text x="${x(val)}" y="10" font-family="var(--mono)" font-size="11" font-weight="600" fill="${col}" text-anchor="middle">${fmt(val)}</text>`; | |
| } | |
| s += `<text x="${W-P}" y="20" font-family="var(--mono)" font-size="10" fill="var(--sub)" text-anchor="end">${esc(unit||"")}</text></svg>`; | |
| return s; | |
| } | |
| function partitionChart(rows,unit,useSI){ | |
| const pts = rows.map(r=>({r, rg: useSI? r.si : r.cv})).filter(p=>p.rg); | |
| if(!pts.length) return ""; | |
| const vals=[]; pts.forEach(p=>{if(p.rg.lo!==null)vals.push(p.rg.lo); if(p.rg.hi!==null)vals.push(p.rg.hi);}); | |
| if(!vals.length) return ""; | |
| const mn=Math.min(...vals), mx=Math.max(...vals), pad=((mx-mn)||Math.abs(mx)||1)*0.08; | |
| const lo=mn-pad, hi=mx+pad; | |
| const W=640,L=160,R=28,rh=22,H=pts.length*rh+34, x=v=>L+((v-lo)/((hi-lo)||1))*(W-L-R); | |
| let s=`<svg viewBox="0 0 ${W} ${H}">`; | |
| [lo,(lo+hi)/2,hi].forEach(t=>{ | |
| s+=`<line x1="${x(t)}" y1="16" x2="${x(t)}" y2="${H-20}" stroke="var(--rule)"/>`; | |
| s+=`<text x="${x(t)}" y="${H-6}" font-family="var(--mono)" font-size="10" fill="var(--sub)" text-anchor="middle">${fmt(t)}</text>`; | |
| }); | |
| pts.forEach((p,i)=>{ | |
| const y=26+i*rh, a=p.rg.lo===null?lo:p.rg.lo, b=p.rg.hi===null?hi:p.rg.hi; | |
| const lab=p.r.cond.length>24? p.r.cond.slice(0,23)+"\u2026" : (p.r.cond||"\u2014"); | |
| s+=`<text x="${L-8}" y="${y+4}" font-family="var(--mono)" font-size="10.5" fill="var(--ink)" text-anchor="end">${esc(lab)}</text>`; | |
| s+=`<rect x="${x(a)}" y="${y-5}" width="${Math.max(2,x(b)-x(a))}" height="10" rx="2" fill="var(--accentSoft)" stroke="var(--accent)"/>`; | |
| s+=`<line x1="${x(a)}" y1="${y-8}" x2="${x(a)}" y2="${y+8}" stroke="var(--accent)" stroke-width="1.5"/>`; | |
| s+=`<line x1="${x(b)}" y1="${y-8}" x2="${x(b)}" y2="${y+8}" stroke="var(--accent)" stroke-width="1.5"/>`; | |
| }); | |
| s+=`<text x="${W-R}" y="12" font-family="var(--mono)" font-size="10" fill="var(--sub)" text-anchor="end">${esc(unit||"")}</text></svg>`; | |
| return s; | |
| } | |
| function ageChart(rows,unit,useSI){ | |
| const pts = rows.map(r=>({r, rg: useSI? r.si : r.cv})) | |
| .filter(p=>p.rg && p.r.a0!==null && p.rg.lo!==null && p.rg.hi!==null); | |
| if(pts.length<3) return ""; | |
| const vals=[],ages=[]; | |
| pts.forEach(p=>{vals.push(p.rg.lo,p.rg.hi); ages.push(p.r.a0, Math.min(p.r.a1,90));}); | |
| const vlo=Math.min(...vals), vhi=Math.max(...vals), alo=Math.min(...ages), ahi=Math.max(...ages); | |
| const W=640,H=250,L=54,R=18,T=18,B=34; | |
| const lg=a=>Math.log10(a+0.05); | |
| const px=a=>L+((lg(a)-lg(alo))/((lg(ahi)-lg(alo))||1))*(W-L-R); | |
| const py=v=>T+(1-(v-vlo)/((vhi-vlo)||1))*(H-T-B); | |
| const COL={M:"var(--low)",F:"#B3268C","":"var(--accent)"}; | |
| let s=`<svg viewBox="0 0 ${W} ${H}">`; | |
| [vlo,(vlo+vhi)/2,vhi].forEach(v=>{ | |
| s+=`<line x1="${L}" y1="${py(v)}" x2="${W-R}" y2="${py(v)}" stroke="var(--rule)"/>`; | |
| s+=`<text x="${L-6}" y="${py(v)+3}" font-family="var(--mono)" font-size="10" fill="var(--sub)" text-anchor="end">${fmt(v)}</text>`; | |
| }); | |
| const AT=[[0.02,"1 wk"],[0.25,"3 mo"],[1,"1 y"],[5,"5 y"],[12,"12 y"],[18,"18 y"],[40,"40 y"],[80,"80 y"]]; | |
| AT.forEach(([a,lab])=>{ if(a>=alo-0.02 && a<=ahi+5) | |
| s+=`<text x="${px(a)}" y="${H-12}" font-family="var(--mono)" font-size="10" fill="var(--sub)" text-anchor="middle">${lab}</text>`;}); | |
| pts.forEach(p=>{ | |
| const c=COL[p.r.sex||""], x0=px(p.r.a0), x1=px(Math.min(p.r.a1,90)); | |
| s+=`<rect x="${x0}" y="${py(p.rg.hi)}" width="${Math.max(2,x1-x0)}" height="${Math.max(2,py(p.rg.lo)-py(p.rg.hi))}" fill="${c}" opacity="0.13"/>`; | |
| s+=`<line x1="${x0}" y1="${py(p.rg.hi)}" x2="${x1}" y2="${py(p.rg.hi)}" stroke="${c}" stroke-width="1.8"/>`; | |
| s+=`<line x1="${x0}" y1="${py(p.rg.lo)}" x2="${x1}" y2="${py(p.rg.lo)}" stroke="${c}" stroke-width="1.8"/>`; | |
| }); | |
| s+=`<text x="${W-R}" y="12" font-family="var(--mono)" font-size="10" fill="var(--sub)" text-anchor="end">${esc(unit||"")} vs age (log)</text></svg>`; | |
| return s; | |
| } | |
| /* ---------- biological variation (Ricos 2014) ---------- */ | |
| function bvSpecs(cvi,cvg){ | |
| const cvt = cvg!=null? Math.sqrt(cvi*cvi+cvg*cvg) : null; | |
| const mk=(fi,fb)=>{ | |
| const I=fi*cvi, Bs= cvt!=null? fb*cvt : null; | |
| return {I, B:Bs, TE: Bs!=null? 1.65*I+Bs : null}; | |
| }; | |
| return {optimal:mk(0.25,0.125), desirable:mk(0.5,0.25), minimum:mk(0.75,0.375)}; | |
| } | |
| function bvBox(A){ | |
| const b=A.bv; if(!b) return ""; | |
| const sp=bvSpecs(b.cvi,b.cvg); | |
| const cell=v=> v==null? "\u2014" : v.toFixed(2); | |
| const row=(k,o)=>`<tr><td class="k">${k}</td><td class="n">${cell(o.I)}</td><td class="n">${cell(o.B)}</td><td class="n">${cell(o.TE)}</td></tr>`; | |
| const cvt = b.cvg!=null? Math.sqrt(b.cvi*b.cvi+b.cvg*b.cvg) : null; | |
| const II = cvt!=null? (b.cvi/b.cvg) : null; | |
| return `<div class="bv"> | |
| <div class="lbl" style="color:var(--accent)">Biological Variation & Analytical Goals</div> | |
| <div style="font-size:13.5px;margin-top:4px">${esc(b.sp)}- ${esc(b.nm)} | |
| <span class="meta">\u00b7 ${esc(b.n||"?")} paper${b.n==="1"?"":"s"}</span></div> | |
| <div class="meta" style="margin-top:6px">CV<sub>I</sub> ${b.cvi.toFixed(2)}% | |
| \u00b7 CV<sub>G</sub> ${b.cvg!=null? b.cvg.toFixed(2)+"%" : "not reported"} | |
| ${II!=null? " \u00b7 index of individuality "+II.toFixed(2) : ""} | |
| \u00b7 RCV \u00b1${(2.77*b.cvi).toFixed(1)}% (95%, CV<sub>I</sub> alone \u2014 add your CV<sub>A</sub> in quadrature)</div> | |
| <table><thead><tr><th>Specification</th><th>Imprecision I (%)</th><th>Bias B (%)</th><th>Total error TE (%)</th></tr></thead> | |
| <tbody>${row("Optimal",sp.optimal)}${row("Desirable",sp.desirable)}${row("Minimum",sp.minimum)}</tbody></table> | |
| <div class="meta" style="margin-top:8px;line-height:1.6"> | |
| Ricos C, Alvarez V, Cava F, et al. Scand J Clin Lab Invest 1999;59:491\u2013500 \u2014 database as updated 2014, | |
| hosted by Westgard QC. I = f\u00b7CV<sub>I</sub>; B = f\u00b7\u221a(CV<sub>I</sub>\u00b2+CV<sub>G</sub>\u00b2); | |
| TE = 1.65\u00b7I + B, with f = 0.25 / 0.5 / 0.75 (bias 0.125 / 0.25 / 0.375). | |
| EFLM now maintains the successor database (biologicalvariation.eu).</div> | |
| </div>`; | |
| } | |
| /* ---------- picker ---------- */ | |
| function pickerHTML(){ | |
| const sel = S.sel!==null? ITEMS[S.sel] : null; | |
| const shown = S.open? S.q : (sel? sel.name : ""); | |
| let list=""; | |
| if(S.open){ | |
| const q=S.q.trim().toLowerCase(); | |
| let arr = ITEMS.filter(a=> S.srcFilter==="all" || a.src===S.srcFilter); | |
| if(q) arr = arr.filter(a=>a.name.toLowerCase().includes(q)); | |
| arr = arr.slice(0,80); | |
| list = `<div class="drop">` + (arr.length? arr.map(a=> | |
| `<div class="opt" data-pick="${a.id}">${esc(a.name)}<span class="src">${esc(SRCSHORT[a.src])}</span> | |
| <span class="meta"> ${esc(a.blocks.map(b=>b.sp).filter(Boolean).join(" \u00b7 ").slice(0,44))}</span></div>`).join("") | |
| : `<div class="opt">No analyte matches that.</div>`) + `</div>`; | |
| } | |
| const chips = ["all","A1","A2","A3","A4"].map(k=> | |
| `<button class="chip ${S.srcFilter===k?"on":""}" data-src="${k}">${k==="all"?"All Tables":SRCLABEL[k]}</button>`).join(""); | |
| return `<div class="chips" style="margin-bottom:12px">${chips}</div> | |
| <div style="position:relative"> | |
| <div class="lbl">Analyte, drug or marker</div> | |
| <input id="pick" autocomplete="off" placeholder="Type to search" value="${esc(shown)}"> | |
| ${list} | |
| </div>`; | |
| } | |
| /* ---------- RefCheck ---------- */ | |
| function renderCheck(){ | |
| const A = S.sel!==null? ITEMS[S.sel] : null; | |
| const B = A? A.blocks[Math.min(S.bi, A.blocks.length-1)] : null; | |
| const f = B && isFinite(B.fnum)? B.fnum : null; | |
| const hasCU = !!(B && B.cu), hasSU = !!(B && B.su); | |
| if(B){ | |
| if(S.unitMode==="cu" && !hasCU && hasSU) S.unitMode="su"; | |
| else if(S.unitMode==="su" && !hasSU && hasCU) S.unitMode="cu"; | |
| } | |
| const unitOpts = []; | |
| if(hasCU) unitOpts.push(["cu", B.cu]); | |
| if(hasSU) unitOpts.push(["su", B.su]); | |
| if(!unitOpts.length) unitOpts.push([S.unitMode, "value"]); | |
| const hasAge = B? B.rows.some(r=>r.a0!==null) : true; | |
| const hasSex = B? B.rows.some(r=>!!r.sex) : true; | |
| const ageY = (!hasAge || S.age==="")? null : parseFloat(S.age)*(AGEU[S.ageU]||1); | |
| const sexV = hasSex? S.sex : "any"; | |
| const raw = S.val===""? null : parseFloat(S.val); | |
| const convVal = raw===null? null : (S.unitMode==="cu"? raw : (f? raw/f : null)); | |
| const siVal = raw===null? null : (S.unitMode==="su"? raw : (f? raw*f : null)); | |
| let h = pickerHTML(); | |
| if(A && A.blocks.length>1){ | |
| h += `<div style="margin-top:14px"><div class="lbl">Specimen / method block</div><div class="chips">` + | |
| A.blocks.map((b,i)=>`<button class="chip ${i===S.bi?"on":""}" data-blk="${i}">${esc([b.sp||"\u2014", b.cu||b.su].filter(Boolean).join(" \u00b7 "))}</button>`).join("") + | |
| `</div></div>`; | |
| } | |
| h += `<div class="row" style="margin-top:14px"> | |
| <div><div class="lbl">Age</div> | |
| <div style="display:flex;gap:6px"> | |
| <input id="age" inputmode="decimal" placeholder="${hasAge?"e.g. 32":"not partitioned"}" value="${esc(S.age)}" style="flex:1" ${hasAge?"":"disabled"}> | |
| <select id="ageU" style="width:96px" ${hasAge?"":"disabled"}> | |
| ${["y|years","mo|months","wk|weeks","d|days"].map(o=>{const[v,t]=o.split("|"); | |
| return `<option value="${v}" ${S.ageU===v?"selected":""}>${t}</option>`;}).join("")} | |
| </select></div></div> | |
| <div><div class="lbl">Sex</div> | |
| <select id="sex" ${hasSex?"":"disabled"}>${[["any","Not specified"],["M","Male"],["F","Female"]].map(([v,t])=> | |
| `<option value="${v}" ${S.sex===v?"selected":""}>${t}</option>`).join("")}</select></div> | |
| <div><div class="lbl">Result</div> | |
| <div style="display:flex;gap:6px"> | |
| <input id="val" inputmode="decimal" placeholder="value" value="${esc(S.val)}" style="flex:1"> | |
| <select id="unitMode" style="width:118px" ${unitOpts.length>1?"":"disabled"}> | |
| ${unitOpts.map(([v,t])=>`<option value="${v}" ${S.unitMode===v?"selected":""}>${esc(t)}</option>`).join("")} | |
| </select></div></div> | |
| </div>`; | |
| if(A && (!hasAge || !hasSex)){ | |
| const miss = !hasAge && !hasSex? "age or sex" : !hasAge? "age" : "sex"; | |
| const by = A.src==="A3"? "by status (therapeutic, toxic, peak, trough)" | |
| : (!hasAge && !hasSex)? "by condition only" : "only on the axis left active"; | |
| h += `<div class="note" style="border-left:3px solid var(--rule);padding-left:10px"> | |
| Tietz does not partition this block by ${miss} \u2014 it lists intervals ${by}, so | |
| that field is off. Every partition in the block is shown below.</div>`; | |
| } | |
| if(B && raw!==null){ | |
| let line; | |
| if(hasCU && hasSU){ | |
| line = `${fmt(convVal)} ${esc(B.cu)} \u2261 ${fmt(siVal)} ${esc(B.su)} | |
| <span style="color:var(--sub)"> ${f? "(\u00d7 "+esc(B.f)+")" : "conversion factor not listed"}</span>`; | |
| } else { | |
| const u = hasCU? B.cu : (B.su || ""); | |
| line = `${fmt(raw)} ${esc(u)}<span style="color:var(--sub)"> only one unit is listed for this block</span>`; | |
| } | |
| h += `<div style="margin-top:14px;padding:11px 12px;background:var(--paper);border:1px solid var(--rule); | |
| border-radius:7px;font-family:var(--mono);font-size:12.5px">${line}</div>`; | |
| } | |
| if(!A){ h += `<div class="empty">Pick an analyte, drug or hematology marker to check a result against Tietz 7e values.</div>`; } | |
| if(A){ | |
| const matches = B.rows.filter(r=>{ | |
| if(!r.cv && !r.si) return false; | |
| if(r.sex && sexV!=="any" && r.sex!==sexV) return false; | |
| if(ageY!==null && r.a0!==null) return ageY>=r.a0-1e-9 && ageY<=r.a1+1e-9; | |
| return ageY===null; | |
| }); | |
| if(ageY!==null && !matches.length){ | |
| h += `<div class="empty">No partition covers that age in this block. Non-age partitions (cord, premature, therapeutic, toxic, timed, postural) are in RefSurf. Clear the age field to see every partition.</div>`; | |
| } | |
| matches.forEach(r=>{ | |
| const cvR = r.cv || (r.si && f? scaleR(r.si,1/f) : null); | |
| const siR = r.si || (r.cv && f? scaleR(r.cv,f) : null); | |
| let useConv = S.unitMode==="cu"; | |
| if(useConv && (!hasCU || !cvR) && hasSU && siR) useConv=false; | |
| else if(!useConv && (!hasSU || !siR) && hasCU && cvR) useConv=true; | |
| const v = verdict(useConv?convVal:siVal, useConv?cvR:siR); | |
| const bad = v==="in"? ["Within interval","var(--ok)","var(--okSoft)"] | |
| : v==="low"? ["Below interval","var(--low)","#E8EFFA"] | |
| : v==="high"? ["Above interval","var(--high)","#FBEAE9"] | |
| : ["Enter a result","var(--sub)","var(--paper)"]; | |
| h += `<div class="card"> | |
| <div style="display:flex;justify-content:space-between;gap:8px;flex-wrap:wrap;align-items:baseline"> | |
| <div style="font-size:15.5px;font-weight:600">${esc(A.name)}<span class="src">${esc(SRCSHORT[A.src])}</span></div> | |
| <div class="meta">${esc([B.sp,r.cond].filter(Boolean).join(" \u00b7 "))}${r.ref? " \u00b7 ref "+esc(r.ref):""}</div> | |
| </div> | |
| <div class="badge" style="color:${bad[1]};background:${bad[2]}">${bad[0]}</div> | |
| <div class="row" style="margin-top:12px"> | |
| ${hasCU? statBox("Conventional ("+B.cu+")", rangeText(cvR,""), convVal, S.unitMode==="cu") : ""} | |
| ${hasSU? statBox("SI ("+B.su+")", rangeText(siR,""), siVal, S.unitMode==="su") : ""} | |
| </div> | |
| <div style="margin-top:10px">${rail(useConv?cvR:siR, useConv?convVal:siVal, useConv?B.cu:B.su)}</div> | |
| <div class="srcline"> | |
| <span>Tietz 7e \u00b7 Appendix A</span><span>${esc(TABLECODE[A.src])}</span> | |
| <span>Analyte #${A.serial}</span><span>${esc(B.page||A.page||"")}</span> | |
| <span>${esc(SRCLABEL[A.src])}</span></div> | |
| </div>`; | |
| }); | |
| const cs = critFor(A.name); | |
| if(cs.length){ | |
| h += `<div class="card" style="border-color:var(--crit);background:var(--critSoft)"> | |
| <div class="lbl" style="color:var(--crit)">Critical values (Table A.5)</div>` + | |
| cs.map(c=>{ | |
| const conv = (c.lo||c.hi)? `<span style="font-family:var(--mono)">${esc(c.lo||"\u2014")} / ${esc(c.hi||"\u2014")} ${esc(c.cu)}</span> <span class="meta">\u00b7 </span>` : ""; | |
| return `<div style="font-size:13.5px;margin-top:6px">${esc(c.name)} \u2014 ${conv} | |
| <span style="font-family:var(--mono)">${esc(c.loSI||"\u2014")} / ${esc(c.hiSI||"\u2014")} ${esc(c.su)}</span> | |
| <span class="meta">\u00b7 ref ${esc(c.ref)}${c.page? " \u00b7 Tietz 7e "+esc(c.page):""}</span></div>`;}).join("") + | |
| `<div class="meta" style="margin-top:8px">lower / upper risk threshold</div></div>`; | |
| } | |
| h += bvBox(A); | |
| } | |
| document.getElementById("pane-check").innerHTML = h; | |
| } | |
| function statBox(k,v,obs,active){ | |
| return `<div style="background:${active?"var(--accentSoft)":"var(--paper)"};border:1px solid ${active?"var(--accent)":"var(--rule)"};border-radius:9px;padding:11px"> | |
| <div class="lbl">${esc(k)}</div> | |
| <div style="font-family:var(--mono);font-size:15px">${esc(v)}</div> | |
| <div class="meta" style="margin-top:3px">result ${fmt(obs)}</div></div>`; | |
| } | |
| /* ---------- RefSurf ---------- */ | |
| function renderSurf(){ | |
| const A = S.sel!==null? ITEMS[S.sel] : null; | |
| let h = pickerHTML(); | |
| if(!A){ | |
| h += `<div class="empty">Pick an analyte to see every partition Tietz lists for it \u2014 as a table, as range bars, and against age where the partitions allow it.</div>`; | |
| document.getElementById("pane-surf").innerHTML = h; return; | |
| } | |
| h += `<div style="display:flex;justify-content:space-between;align-items:center;flex-wrap:wrap;gap:10px;margin-top:18px"> | |
| <div><div style="font-size:20px;font-weight:600">${esc(A.name)}</div> | |
| <div class="meta" style="margin-top:3px">${esc(SRCLABEL[A.src])} \u00b7 ${esc(TABLECODE[A.src])} \u00b7 Analyte #${A.serial} | |
| ${A.page? " \u00b7 Tietz 7e "+esc(A.page):""} \u00b7 ${A.blocks.length} block${A.blocks.length>1?"s":""} \u00b7 | |
| ${A.blocks.reduce((n,b)=>n+b.rows.length,0)} partitions</div></div> | |
| <div class="chips"> | |
| <button class="chip ${!S.useSI?"on":""}" data-si="0">Conventional</button> | |
| <button class="chip ${S.useSI?"on":""}" data-si="1">SI</button></div></div>`; | |
| if(A.notes.length) h += `<div class="note">${esc(A.notes.join(" \u00b7 "))}</div>`; | |
| A.blocks.forEach(b=>{ | |
| const f=b.fnum; | |
| const colCU = !!b.cu && b.rows.some(r=>r.cvS || (r.si && isFinite(f))); | |
| const colSU = !!b.su && b.rows.some(r=>r.siS || (r.cv && isFinite(f))); | |
| h += `<div class="card"> | |
| <div class="meta" style="display:flex;gap:14px;flex-wrap:wrap;border-bottom:1px solid var(--rule);padding-bottom:10px"> | |
| <span style="color:var(--accent)">${esc(b.sp||"specimen not stated")}</span> | |
| ${colCU? `<span>conv. ${esc(b.cu)}</span>`:""}${colSU? `<span>SI ${esc(b.su)}</span>`:""} | |
| ${(colCU&&colSU&&b.f)? `<span>factor ${esc(b.f)}</span>`:""}${b.page? `<span>Tietz 7e ${esc(b.page)}</span>`:""}</div> | |
| <table><thead><tr><th>Partition</th>${colCU?`<th>Conventional ${esc(b.cu)}</th>`:""}${colSU?`<th>SI ${esc(b.su)}</th>`:""}<th>Ref</th></tr></thead><tbody>` + | |
| b.rows.map(r=>{ | |
| const cvT = r.cvS || (r.si&&isFinite(f)? rangeText(scaleR(r.si,1/f),"")+"*" : "\u2014"); | |
| const siT = r.siS || (r.cv&&isFinite(f)? rangeText(scaleR(r.cv,f),"")+"*" : "\u2014"); | |
| return `<tr><td>${esc(r.cond||"\u2014")}${r.sex? ` <span class="meta">[${r.sex}]</span>`:""}</td> | |
| ${colCU?`<td class="n">${esc(cvT)}</td>`:""}${colSU?`<td class="n">${esc(siT)}</td>`:""}<td class="meta">${esc(r.ref||"")}</td></tr>`; | |
| }).join("") + `</tbody></table> | |
| <div style="margin-top:14px">${partitionChart(b.rows, (S.useSI&&colSU)||!colCU? b.su : b.cu, (S.useSI&&colSU)||!colCU)}</div> | |
| <div style="margin-top:6px">${ageChart(b.rows, (S.useSI&&colSU)||!colCU? b.su : b.cu, (S.useSI&&colSU)||!colCU)}</div></div>`; | |
| }); | |
| const cs = critFor(A.name); | |
| if(cs.length){ | |
| h += `<div class="card" style="border-color:var(--crit);background:var(--critSoft)"> | |
| <div class="lbl" style="color:var(--crit)">Critical values (Table A.5)</div>` + | |
| cs.map(c=>{ | |
| const conv = (c.lo||c.hi)? `<span style="font-family:var(--mono)">${esc(c.lo||"\u2014")} / ${esc(c.hi||"\u2014")} ${esc(c.cu)}</span> <span class="meta">\u00b7 </span>` : ""; | |
| return `<div style="font-size:13.5px;margin-top:6px">${esc(c.name)} \u2014 ${conv} | |
| <span style="font-family:var(--mono)">${esc(c.loSI||"\u2014")} / ${esc(c.hiSI||"\u2014")} ${esc(c.su)}</span></div>`;}).join("") + `</div>`; | |
| } | |
| h += bvBox(A); | |
| h += `<div class="meta" style="margin-top:10px">* computed from the listed conversion factor, not printed in the source table.</div>`; | |
| document.getElementById("pane-surf").innerHTML = h; | |
| } | |
| /* ---------- Critical ---------- */ | |
| function renderCrit(){ | |
| const q = S.critQ.trim().toLowerCase(); | |
| const rows = CRIT.filter(c=>!q || c.name.toLowerCase().includes(q)); | |
| document.getElementById("pane-crit").innerHTML = ` | |
| <div class="lbl">Search critical values</div> | |
| <input id="critq" autocomplete="off" placeholder="e.g. potassium" value="${esc(S.critQ)}"> | |
| <div class="card"> | |
| <table><thead><tr><th>Parameter</th><th>Lower / upper (conv.)</th><th>Lower / upper (SI)</th><th>Ref</th><th>Page</th></tr></thead><tbody>` + | |
| (rows.length? rows.map(c=>`<tr> | |
| <td>${esc(c.name)}</td> | |
| <td class="n">${esc(c.lo)} / ${esc(c.hi)} <span class="meta">${esc(c.cu)}</span></td> | |
| <td class="n">${esc(c.loSI)} / ${esc(c.hiSI)} <span class="meta">${esc(c.su)}</span></td> | |
| <td class="meta">${esc(c.ref)}</td><td class="meta">${esc(c.page)}</td></tr>`).join("") | |
| : `<tr><td colspan="5" class="meta">No parameter matches that.</td></tr>`) + | |
| `</tbody></table></div> | |
| <div class="note">Table A.5 lists risk thresholds, not reference intervals. Local critical-value policy and callback lists override these.</div>`; | |
| } | |
| /* ---------- render + events ---------- */ | |
| function render(){ | |
| ["check","surf","crit"].forEach(t=>{ | |
| document.getElementById("pane-"+t).classList.toggle("hide", S.tab!==t); | |
| }); | |
| document.querySelectorAll(".tab").forEach(b=>b.classList.toggle("on", b.dataset.tab===S.tab)); | |
| if(S.tab==="check") renderCheck(); | |
| else if(S.tab==="surf") renderSurf(); | |
| else renderCrit(); | |
| const p=document.getElementById("pick"); | |
| if(p && S.open){ p.focus(); if(document.activeElement===p) p.setSelectionRange(p.value.length,p.value.length); } | |
| } | |
| document.addEventListener("click", e=>{ | |
| const t=e.target.closest("[data-tab],[data-pick],[data-blk],[data-src],[data-si]"); | |
| if(!t){ if(S.open && !e.target.closest("#pick")){ S.open=false; render(); } return; } | |
| if(t.dataset.tab){ S.tab=t.dataset.tab; S.open=false; } | |
| else if(t.dataset.pick!==undefined){ S.sel=+t.dataset.pick; S.bi=0; S.open=false; S.q=""; } | |
| else if(t.dataset.blk!==undefined){ S.bi=+t.dataset.blk; } | |
| else if(t.dataset.src){ S.srcFilter=t.dataset.src; S.open=true; } | |
| else if(t.dataset.si!==undefined){ S.useSI = t.dataset.si==="1"; } | |
| render(); | |
| }); | |
| document.addEventListener("input", e=>{ | |
| const id=e.target.id; | |
| if(id==="pick"){ S.q=e.target.value; S.open=true; render(); } | |
| else if(id==="age"||id==="val"){ | |
| if(id==="age") S.age=e.target.value; else S.val=e.target.value; | |
| const c=e.target.selectionStart; renderCheck(); | |
| const n=document.getElementById(id); if(n){ n.focus(); try{n.setSelectionRange(c,c);}catch(_){} } } | |
| else if(id==="critq"){ S.critQ=e.target.value; const c=e.target.selectionStart; renderCrit(); | |
| const n=document.getElementById("critq"); n.focus(); n.setSelectionRange(c,c); } | |
| }); | |
| document.addEventListener("change", e=>{ | |
| const id=e.target.id; | |
| if(id==="ageU") S.ageU=e.target.value; | |
| else if(id==="sex") S.sex=e.target.value; | |
| else if(id==="unitMode") S.unitMode=e.target.value; | |
| else return; | |
| renderCheck(); | |
| }); | |
| document.addEventListener("focusin", e=>{ if(e.target.id==="pick" && !S.open){ S.open=true; S.q=""; render(); }}); | |
| render(); | |
| </script> | |
| </body> | |
| </html> | |