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"1": "Oxidoreductases",
"1.1": "Acting on the CH-OH group of donors",
"1.1.1": "With NAD(+) or NADP(+) as acceptor",
"1.1.2": "With a cytochrome as acceptor",
"1.1.3": "With oxygen as acceptor",
"1.1.4": "With a disulfide as acceptor",
"1.1.5": "With a quinone or similar compound as acceptor",
"1.1.7": "With an iron-sulfur protein as acceptor",
"1.1.9": "With a copper protein as acceptor",
"1.1.98": "With other, known, acceptors",
"1.1.99": "With other acceptors",
"1.2": "Acting on the aldehyde or oxo group of donors",
"1.2.1": "With NAD(+) or NADP(+) as acceptor",
"1.2.2": "With a cytochrome as acceptor",
"1.2.3": "With oxygen as acceptor",
"1.2.4": "With a disulfide as acceptor",
"1.2.5": "With a quinone or similar compound as acceptor",
"1.2.7": "With an iron-sulfur protein as acceptor",
"1.2.8": "With a flavin or flavoprotein as acceptor",
"1.2.98": "With other, known, acceptors",
"1.2.99": "With other acceptors",
"1.3": "Acting on the CH-CH group of donors",
"1.3.1": "With NAD(+) or NADP(+) as acceptor",
"1.3.2": "With a cytochrome as acceptor",
"1.3.3": "With oxygen as acceptor",
"1.3.4": "With a disulfide as acceptor",
"1.3.5": "With a quinone or related compound as acceptor",
"1.3.7": "With an iron-sulfur protein as acceptor",
"1.3.8": "With a flavin as acceptor",
"1.3.98": "With other, known, acceptors",
"1.3.99": "With other acceptors",
"1.4": "Acting on the CH-NH2 group of donors",
"1.4.1": "With NAD(+) or NADP(+) as acceptor",
"1.4.2": "With a cytochrome as acceptor",
"1.4.3": "With oxygen as acceptor",
"1.4.4": "With a disulfide as acceptor",
"1.4.5": "With a quinone or similar compound as acceptor",
"1.4.7": "With an iron-sulfur protein as acceptor",
"1.4.9": "With a copper protein as acceptor",
"1.4.98": "With other, known, acceptors",
"1.4.99": "With other acceptors",
"1.5": "Acting on the CH-NH group of donors",
"1.5.1": "With NAD(+) or NADP(+) as acceptor",
"1.5.3": "With oxygen as acceptor",
"1.5.4": "With a disulfide as acceptor",
"1.5.5": "With a quinone or similar compound as acceptor",
"1.5.7": "With an iron-sulfur protein as acceptor",
"1.5.8": "With a flavin as acceptor",
"1.5.98": "With other, known, acceptors",
"1.5.99": "With other acceptors",
"1.6": "Acting on NADH or NADPH",
"1.6.1": "With NAD(+) or NADP(+) as acceptor",
"1.6.2": "With a heme protein as acceptor",
"1.6.3": "With oxygen as acceptor",
"1.6.4": "With a disulfide as acceptor",
"1.6.5": "With a quinone or similar compound as acceptor",
"1.6.6": "With a nitrogenous group as acceptor",
"1.6.7": "With a iron-sulfur protein as acceptor",
"1.6.8": "With a flavin as acceptor",
"1.6.99": "With other acceptors",
"1.7": "Acting on other nitrogenous compounds as donors",
"1.7.1": "With NAD(+) or NADP(+) as acceptor",
"1.7.2": "With a cytochrome as acceptor",
"1.7.3": "With oxygen as acceptor",
"1.7.5": "With a quinone or similar compound as acceptor",
"1.7.6": "With a nitrogenous group as acceptor",
"1.7.7": "With an iron-sulfur protein as acceptor",
"1.7.9": "With a copper protein as acceptor",
"1.7.99": "With other acceptors",
"1.8": "Acting on a sulfur group of donors",
"1.8.1": "With NAD(+) or NADP(+) as acceptor",
"1.8.2": "With a cytochrome as acceptor",
"1.8.3": "With oxygen as acceptor",
"1.8.4": "With a disulfide as acceptor",
"1.8.5": "With a quinone or similar compound as acceptor",
"1.8.6": "With an nitrogenous group as acceptor",
"1.8.7": "With an iron-sulfur protein as acceptor",
"1.8.98": "With other, known, acceptors",
"1.8.99": "With other acceptors",
"1.9": "Acting on a heme group of donors",
"1.9.3": "With oxygen as acceptor",
"1.9.6": "With a nitrogenous group as acceptor",
"1.9.98": "With other, known, acceptors",
"1.9.99": "With other acceptors",
"1.10": "Acting on diphenols and related substances as donors",
"1.10.1": "With NAD(+) or NADP(+) as acceptor",
"1.10.2": "With a cytochrome as acceptor",
"1.10.3": "With oxygen as acceptor",
"1.10.5": "With a quinone or related compound as acceptor",
"1.10.9": "With a copper protein as acceptor",
"1.10.98": "With other, known, acceptors",
"1.10.99": "With other acceptors",
"1.11": "Acting on a peroxide as acceptor",
"1.11.1": "Peroxidases",
"1.11.2": "With H2O2 as acceptor, one oxygen atom of which is incorporated into the product",
"1.12": "Acting on hydrogen as donors",
"1.12.1": "With NAD(+) or NADP(+) as acceptor",
"1.12.2": "With a cytochrome as acceptor",
"1.12.5": "With a quinone or similar compound as acceptor",
"1.12.7": "With an iron-sulfur protein as acceptor",
"1.12.98": "With other, known, acceptors",
"1.12.99": "With other acceptors",
"1.13": "Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2",
"1.13.1": "With NADH or NADPH as one donor",
"1.13.11": "With incorporation of two atoms of oxygen",
"1.13.12": "With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)",
"1.13.99": "Miscellaneous",
"1.14": "Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2",
"1.14.1": "With NADH or NADPH as one donor",
"1.14.2": "With ascorbate as one donor",
"1.14.3": "With reduced pteridine as one donor",
"1.14.11": "With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors",
"1.14.12": "With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor",
"1.14.13": "With NADH or NADPH as one donor, and incorporation of one atom of oxygen",
"1.14.14": "With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen",
"1.14.15": "With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen",
"1.14.16": "With reduced pteridine as one donor, and incorporation of one atom of oxygen",
"1.14.17": "With reduced ascorbate as one donor, and incorporation of one atom of oxygen",
"1.14.18": "With another compound as one donor, and incorporation of one atom of oxygen",
"1.14.19": "With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water",
"1.14.20": "With 2-oxoglutarate as one donor, and the other dehydrogenated",
"1.14.21": "With NADH or NADPH as one donor, and the other dehydrogenated",
"1.14.99": "Miscellaneous",
"1.15": "Acting on superoxide as acceptor",
"1.15.1": "Acting on superoxide as acceptor",
"1.16": "Oxidizing metal ions",
"1.16.1": "With NAD(+) or NADP(+) as acceptor",
"1.16.2": "With a cytochrome as acceptor",
"1.16.3": "With oxygen as acceptor",
"1.16.5": "With a quinone or similar compound as acceptor",
"1.16.8": "With a flavin as acceptor",
"1.16.9": "With a copper protein as acceptor",
"1.16.98": "With other known acceptors",
"1.16.99": "With other acceptors",
"1.17": "Acting on CH or CH2 groups",
"1.17.1": "With NAD(+) or NADP(+) as acceptor",
"1.17.2": "With a cytochrome as acceptor",
"1.17.3": "With oxygen as acceptor",
"1.17.4": "With a disulfide as acceptor",
"1.17.5": "With a quinone or similar compound as acceptor",
"1.17.7": "With an iron-sulfur protein as acceptor",
"1.17.8": "With a flavin as acceptor",
"1.17.9": "With a copper protein as acceptor",
"1.17.98": "With other, known, acceptors",
"1.17.99": "With other acceptors",
"1.18": "Acting on iron-sulfur proteins as donors",
"1.18.1": "With NAD(+) or NADP(+) as acceptor",
"1.18.2": "With dinitrogen as acceptor",
"1.18.3": "With H(+) as acceptor",
"1.18.6": "With dinitrogen as acceptor",
"1.18.96": "With other, known, acceptors",
"1.18.99": "With H(+) as acceptor",
"1.19": "Acting on reduced flavodoxin as donor",
"1.19.1": "With NAD(+) or NADP(+) as acceptor",
"1.19.6": "With dinitrogen as acceptor",
"1.20": "Acting on phosphorus or arsenic in donors",
"1.20.1": "With NAD(+) or NADP(+) as acceptor",
"1.20.2": "With a cytochrome as acceptor",
"1.20.4": "With disulfide as acceptor",
"1.20.9": "With a copper protein as acceptor",
"1.20.98": "With other, known acceptors",
"1.20.99": "With other acceptors",
"1.21": "Catalyzing the reaction X-H + Y-H = 'X-Y'",
"1.21.1": "With NAD(+) or NADP(+) as acceptor",
"1.21.3": "With oxygen as acceptor",
"1.21.4": "With a disulfide as acceptor",
"1.21.98": "With other, known acceptors",
"1.21.99": "With other acceptors",
"1.22": "Acting on halogen in donors",
"1.22.1": "With NAD(+) or NADP(+) as acceptor",
"1.23": "Reducing C-O-C group as acceptor",
"1.23.1": "With NADH or NADPH as donor",
"1.23.5": "With a quinone or similar compound as acceptor",
"1.97": "Other oxidoreductases",
"1.97.1": "Other oxidoreductases",
"1.98": "Enzymes using H2 as reductant",
"1.98.1": "Other oxidoreductases",
"1.99": "Other enzymes using O2 as oxidant",
"1.99.1": "Hydroxylases",
"1.99.2": "Oxygenases",
"2": "Transferases",
"2.1": "Transferring one-carbon groups",
"2.1.1": "Methyltransferases",
"2.1.2": "Hydroxymethyl-, formyl- and related transferases",
"2.1.3": "Carboxy- and carbamoyltransferases",
"2.1.4": "Amidinotransferases",
"2.1.5": "Methylenetransferases",
"2.2": "Transferring aldehyde or ketonic groups",
"2.2.1": "Transketolases and transaldolases",
"2.3": "Acyltransferases",
"2.3.1": "Transferring groups other than amino-acyl groups",
"2.3.2": "Aminoacyltransferases",
"2.3.3": "Acyl groups converted into alkyl groups on transfer",
"2.4": "Glycosyltransferases",
"2.4.1": "Hexosyltransferases",
"2.4.2": "Pentosyltransferases",
"2.4.3": "Sialyltransferases",
"2.4.99": "Transferring other glycosyl groups",
"2.5": "Transferring alkyl or aryl groups, other than methyl groups",
"2.5.1": "Transferring alkyl or aryl groups, other than methyl groups",
"2.6": "Transferring nitrogenous groups",
"2.6.1": "Transaminases",
"2.6.2": "Amidinotransferases",
"2.6.3": "Oximinotransferases",
"2.6.99": "Transferring other nitrogenous groups",
"2.7": "Transferring phosphorus-containing groups",
"2.7.1": "Phosphotransferases with an alcohol group as acceptor",
"2.7.2": "Phosphotransferases with a carboxy group as acceptor",
"2.7.3": "Phosphotransferases with a nitrogenous group as acceptor",
"2.7.4": "Phosphotransferases with a phosphate group as acceptor",
"2.7.5": "Phosphotransferases with regeneration of donors, apparently catalyzing intramolecular transfers",
"2.7.6": "Diphosphotransferases",
"2.7.7": "Nucleotidyltransferases",
"2.7.8": "Transferases for other substituted phosphate groups",
"2.7.9": "Phosphotransferases with paired acceptors",
"2.7.10": "Protein-tyrosine kinases",
"2.7.11": "Protein-serine/threonine kinases",
"2.7.12": "Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)",
"2.7.13": "Protein-histidine kinases",
"2.7.14": "Protein-arginine kinases",
"2.7.99": "Other protein kinases",
"2.8": "Transferring sulfur-containing groups",
"2.8.1": "Sulfurtransferases",
"2.8.2": "Sulfotransferases",
"2.8.3": "CoA-transferases",
"2.8.4": "Transferring alkylthio groups",
"2.8.5": "Thiosulfotransferases",
"2.9": "Transferring selenium-containing groups",
"2.9.1": "Selenotransferases",
"2.10": "Transferring molybdenum- or tungsten-containing groups",
"2.10.1": "Molybdenumtransferases or tungstentransferases with sulfide groups as acceptors",
"3": "Hydrolases",
"3.1": "Acting on ester bonds",
"3.1.1": "Carboxylic ester hydrolases",
"3.1.2": "Thiolester hydrolases",
"3.1.3": "Phosphoric monoester hydrolases",
"3.1.4": "Phosphoric diester hydrolases",
"3.1.5": "Triphosphoric monoester hydrolases",
"3.1.6": "Sulfuric ester hydrolases",
"3.1.7": "Diphosphoric monoester hydrolases",
"3.1.8": "Phosphoric triester hydrolases",
"3.1.11": "Exodeoxyribonucleases producing 5'-phosphomonoesters",
"3.1.12": "Exodeoxyribonucleases producing 3'-phosphomonoesters",
"3.1.13": "Exoribonucleases producing 5'-phosphomonoesters",
"3.1.14": "Exoribonucleases producing 3'-phosphomonoesters",
"3.1.15": "Exonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters",
"3.1.16": "Exonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters",
"3.1.21": "Endodeoxyribonucleases producing 5'-phosphomonoesters",
"3.1.22": "Endodeoxyribonucleases producing other than 5'-phosphomonoesters",
"3.1.23": "Site specific endodeoxyribonucleases: cleavage is sequence specific",
"3.1.24": "Site specific endodeoxyribonucleases: cleavage is not sequence specific",
"3.1.25": "Site-specific endodeoxyribonucleases specific for altered bases",
"3.1.26": "Endoribonucleases producing 5'-phosphomonoesters",
"3.1.27": "Endoribonucleases producing other than 5'-phosphomonoesters",
"3.1.30": "Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters",
"3.1.31": "Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters",
"3.2": "Glycosylases",
"3.2.1": "Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds",
"3.2.2": "Hydrolyzing N-glycosyl compounds",
"3.2.3": "Hydrolyzing S-glycosyl compounds",
"3.3": "Acting on ether bonds",
"3.3.1": "Thioether and trialkylsulfonium hydrolases",
"3.3.2": "Ether hydrolases",
"3.4": "Acting on peptide bonds (peptidases)",
"3.4.1": "alpha-Amino-acyl-peptide hydrolases",
"3.4.2": "Peptidyl-amino-acid hydrolases",
"3.4.3": "Dipeptide hydrolases",
"3.4.4": "Peptidyl peptide hydrolases",
"3.4.11": "Aminopeptidases",
"3.4.12": "Peptidylamino-acid hydrolases or acylamino-acid hydrolases",
"3.4.13": "Dipeptidases",
"3.4.14": "Dipeptidyl-peptidases and tripeptidyl-peptidases",
"3.4.15": "Peptidyl-dipeptidases",
"3.4.16": "Serine-type carboxypeptidases",
"3.4.17": "Metallocarboxypeptidases",
"3.4.18": "Cysteine-type carboxypeptidases",
"3.4.19": "Omega peptidases",
"3.4.21": "Serine endopeptidases",
"3.4.22": "Cysteine endopeptidases",
"3.4.23": "Aspartic endopeptidases",
"3.4.24": "Metalloendopeptidases",
"3.4.25": "Threonine endopeptidases",
"3.4.26": "Glutamic endopeptidases",
"3.4.99": "Endopeptidases of unknown catalytic mechanism",
"3.5": "Acting on carbon-nitrogen bonds, other than peptide bonds",
"3.5.1": "In linear amides",
"3.5.2": "In cyclic amides",
"3.5.3": "In linear amidines",
"3.5.4": "In cyclic amidines",
"3.5.5": "In nitriles",
"3.5.99": "In other compounds",
"3.6": "Acting on acid anhydrides",
"3.6.1": "In phosphorus-containing anhydrides",
"3.6.2": "In sulfonyl-containing anhydrides",
"3.6.3": "Acting on acid anhydrides; catalyzing transmembrane movement of substances",
"3.6.4": "Acting on ATP; involved in cellular and subcellular movement",
"3.6.5": "Acting on GTP; involved in cellular and subcellular movement",
"3.7": "Acting on carbon-carbon bonds",
"3.7.1": "In ketonic substances",
"3.8": "Acting on halide bonds",
"3.8.1": "In C-halide compounds",
"3.8.2": "In P-halide compounds",
"3.9": "Acting on phosphorus-nitrogen bonds",
"3.9.1": "Acting on phosphorus-nitrogen bonds",
"3.10": "Acting on sulfur-nitrogen bonds",
"3.10.1": "Acting on sulfur-nitrogen bonds",
"3.11": "Acting on carbon-phosphorus bonds",
"3.11.1": "Acting on carbon-phosphorus bonds",
"3.12": "Acting on sulfur-sulfur bonds",
"3.12.1": "Acting on sulfur-sulfur bonds",
"3.13": "Acting on carbon-sulfur bonds",
"3.13.1": "Acting on carbon-sulfur bonds",
"3.13.2": "Thioether and trialkylsulfonium hydrolases",
"4": "Lyases",
"4.1": "Carbon-carbon lyases",
"4.1.1": "Carboxy-lyases",
"4.1.2": "Aldehyde-lyases",
"4.1.3": "Oxo-acid-lyases",
"4.1.99": "Other carbon-carbon lyases",
"4.2": "Carbon-oxygen lyases",
"4.2.1": "Hydro-lyases",
"4.2.2": "Acting on polysaccharides",
"4.2.3": "Acting on phosphates",
"4.2.99": "Other carbon-oxygen lyases",
"4.3": "Carbon-nitrogen lyases",
"4.3.1": "Ammonia-lyases",
"4.3.2": "Lyases acting on amides, amidines, etc",
"4.3.3": "Amine-lyases",
"4.3.99": "Other carbon-nitrogen lyases",
"4.4": "Carbon-sulfur lyases",
"4.4.1": "Carbon-sulfur lyases",
"4.5": "Carbon-halide lyases",
"4.5.1": "Carbon-halide lyases",
"4.6": "Phosphorus-oxygen lyases",
"4.6.1": "Phosphorus-oxygen lyases",
"4.7": "Carbon-phosphorus lyases",
"4.7.1": "Carbon-phosphorus lyases",
"4.8": "Nitrogen-oxygen lyases",
"4.8.1": "Hydro-lyases",
"4.98": "ATP-independent chelatases",
"4.98.1": "Forming coordination complexes",
"4.99": "Other lyases",
"4.99.1": "Other lyases",
"5": "Isomerases",
"5.1": "Racemases and epimerases",
"5.1.1": "Acting on amino acids and derivatives",
"5.1.2": "Acting on hydroxy acids and derivatives",
"5.1.3": "Acting on carbohydrates and derivatives",
"5.1.99": "Acting on other compounds",
"5.2": "Cis-trans-isomerases",
"5.2.1": "Cis-trans isomerases",
"5.3": "Intramolecular oxidoreductases",
"5.3.1": "Interconverting aldoses and ketoses",
"5.3.2": "Interconverting keto- and enol-groups",
"5.3.3": "Transposing C=C bonds",
"5.3.4": "Transposing S-S bonds",
"5.3.99": "Other intramolecular oxidoreductases",
"5.4": "Intramolecular transferases",
"5.4.1": "Transferring acyl groups",
"5.4.2": "Phosphotransferases (phosphomutases)",
"5.4.3": "Transferring amino groups",
"5.4.4": "Transferring hydroxy groups",
"5.4.99": "Transferring other groups",
"5.5": "Intramolecular lyases",
"5.5.1": "Intramolecular lyases",
"5.6": "Isomerases altering macromolecular conformation",
"5.6.1": "Enzymes altering polypeptide conformation or assembly",
"5.6.2": "Enzymes altering nucleic acid conformation",
"5.99": "Other isomerases",
"5.99.1": "Other isomerases",
"6": "Ligases",
"6.1": "Forming carbon-oxygen bonds",
"6.1.1": "Ligases forming aminoacyl-tRNA and related compounds",
"6.1.2": "Acid--alcohol ligases (ester synthases)",
"6.1.3": "Cyclo-ligases",
"6.2": "Forming carbon-sulfur bonds",
"6.2.1": "Acid--thiol ligases",
"6.2.2": "Amide--thiol ligases",
"6.3": "Forming carbon-nitrogen bonds",
"6.3.1": "Acid--ammonia (or amine) ligases (amide synthases)",
"6.3.2": "Acid--amino-acid ligases (peptide synthases)",
"6.3.3": "Cyclo-ligases",
"6.3.4": "Other carbon--nitrogen ligases",
"6.3.5": "Carbon--nitrogen ligases with glutamine as amido-N-donor",
"6.4": "Forming carbon-carbon bonds",
"6.4.1": "Forming carbon-carbon bonds",
"6.5": "Forming phosphoric ester bonds",
"6.5.1": "Forming phosphoric ester bonds",
"6.6": "Forming nitrogen-metal bonds",
"6.6.1": "Forming coordination complexes",
"6.7": "Forming nitrogen-nitrogen bonds",
"6.7.1": "Forming diazo bonds",
"7": "Translocases",
"7.1": "Catalysing the translocation of hydrons",
"7.1.1": "Hydron translocation or charge separation linked to oxidoreductase reactions",
"7.1.2": "Hydron translocation linked to the hydrolysis of a nucleoside triphosphate",
"7.1.3": "Hydron translocation linked to the hydrolysis of diphosphate",
"7.2": "Catalysing the translocation of inorganic cations",
"7.2.1": "Linked to oxidoreductase reactions",
"7.2.2": "Linked to the hydrolysis of a nucleoside triphosphate",
"7.2.3": "Linked to the hydrolysis of diphosphate",
"7.2.4": "Linked to decarboxylation",
"7.3": "Catalysing the translocation of inorganic anions and their chelates",
"7.3.2": "Linked to the hydrolysis of a nucleoside triphosphate",
"7.4": "Catalysing the translocation amino acids and peptides",
"7.4.2": "Linked to the hydrolysis of a nucleoside triphosphate",
"7.5": "Catalysing the translocation carbohydrates and their derivatives",
"7.5.2": "Linked to the hydrolysis of a nucleoside triphosphate",
"7.6": "Catalysing the translocation of other compounds",
"7.6.2": "Linked to the hydrolysis of a nucleoside triphosphate"
} |