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"type": "object",
"properties": {
"therapy_key": {
"type": "string",
"description": "Echo back verbatim the therapy_key given for this therapy in the prompt."
},
"canonical_name": {
"type": "string",
"description": "Most recognizable canonical name for this therapy. Merge development codes and synonyms to the common name (e.g., 'MCI-186' and 'MT-1186' -> 'Edaravone')."
},
"aliases": {
"type": "array",
"items": {"type": "string"},
"description": "Other names or development codes for this therapy seen across its trials."
},
"modality": {
"type": "string",
"enum": ["Small molecule", "Antisense oligonucleotide", "Biologic/Antibody", "Cell therapy", "Gene therapy", "Peptide", "Dietary supplement", "Combination", "Other"],
"description": "Therapeutic modality."
},
"target": {
"type": "string",
"description": "Primary molecular/biological target (e.g., 'SOD1 mRNA', 'AMPA receptor'). Use 'Unknown' if it cannot be determined from the provided evidence."
},
"mechanisms": {
"type": "array",
"description": "All ALS mechanism classes this therapy is proposed to act through, each supported by a direct quote from the provided evidence. MULTI-LABEL: include every well-supported class. If the evidence does not establish any mechanism, return an EMPTY array (abstain) rather than guessing.",
"items": {
"type": "object",
"properties": {
"class": {
"type": "string",
"enum": ["TDP-43 proteinopathy", "SOD1", "C9orf72", "FUS", "Neuroinflammation", "Oxidative stress", "Mitochondrial dysfunction", "Glutamate excitotoxicity", "Proteostasis / autophagy", "RNA metabolism", "Neurotrophic / regenerative", "Symptomatic / Other"],
"description": "The mechanism class from the ALS taxonomy."
},
"role": {
"type": "string",
"enum": ["primary", "contributing"],
"description": "Whether this is the therapy's primary mechanism or a secondary/contributing one."
},
"confidence": {
"type": "number",
"minimum": 0.0,
"maximum": 1.0,
"description": "Confidence that this therapy acts through this mechanism, based ONLY on the provided evidence (1.0 = well-established, 0.4 = weak/inferred)."
},
"evidence_quote": {
"type": "string",
"description": "A short verbatim quote from the provided evidence that supports this mechanism. Required — if you cannot quote supporting evidence, do not include this mechanism."
}
},
"required": ["class", "role", "confidence", "evidence_quote"]
}
}
},
"required": ["therapy_key", "canonical_name", "modality", "target", "mechanisms"]
}
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