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"type": "object",
"properties": {
"nct_id": {
"type": "string",
"description": "The ClinicalTrials.gov identifier for this trial (echo it back verbatim)."
},
"compound": {
"type": "string",
"description": "The primary drug/agent under test, taken from the trial's interventions. 'unknown' if no investigational agent is identifiable (e.g. a device or behavioral trial)."
},
"targeting_mechanism": {
"type": "string",
"description": "One sentence: the molecular target and mechanism of action. May be drawn from the trial summary itself OR a provided paper passage. 'unknown' if neither states it."
},
"targeting_mechanism_pmid": {
"type": "string",
"description": "PMID of the supporting passage from the EVIDENCE list, if the mechanism came from a paper. Empty string if it came from the trial summary itself or is unknown."
},
"animal_results": {
"type": "string",
"description": "Preclinical / animal-model efficacy findings for this compound. MUST be supported by a passage in the provided EVIDENCE list. 'unknown' if no provided passage reports animal/preclinical results — do NOT use outside knowledge."
},
"animal_results_pmid": {
"type": "string",
"description": "PMID from the EVIDENCE list supporting animal_results. Empty string only when animal_results is 'unknown'."
},
"repurposed_from": {
"type": "string",
"description": "If this is a repurposed drug, its original approved indication (e.g. 'type 2 diabetes'), supported by a provided EVIDENCE passage. 'not repurposed' for agents developed de novo for ALS/neurodegeneration. 'unknown' if no provided passage establishes an original indication — do NOT use outside knowledge."
},
"repurposed_from_pmid": {
"type": "string",
"description": "PMID from the EVIDENCE list supporting repurposed_from. Empty string when repurposed_from is 'not repurposed' or 'unknown'."
}
},
"required": [
"nct_id",
"compound",
"targeting_mechanism",
"targeting_mechanism_pmid",
"animal_results",
"animal_results_pmid",
"repurposed_from",
"repurposed_from_pmid"
]
}
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