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import dynamic from 'next/dynamic';
import Link from 'next/link';
import { useRef } from 'react';
import { motion, useReducedMotion, useScroll, useTransform } from 'framer-motion';
import { ArrowRight, Database, FlowArrow, Brain, CaretDown as ChevronDown } from '@phosphor-icons/react';
import { TiltCard } from '@/components/ui/TiltCard';
import { ThemeToggle } from '@/components/ui/ThemeToggle';
import { JsonLd } from '@/components/seo/JsonLd';
import { ORG_ID, SOFTWARE_ID, SITE_NAME, SITE_URL, WEBPAGE_ID, WEBSITE_ID } from '@/lib/seo';
const DNAHelix = dynamic(
() => import('@/components/three/DNAHelix'),
{ ssr: false, loading: () => <div className="w-full h-full bg-void" /> }
);
const DATABASES = ['NCBI', 'UniProt', 'PDB', 'AlphaFold', 'EMBL', 'InterPro', 'KEGG', 'STRING'];
const DB_GROUPS = [
{ label: 'Portals', names: 'NCBI · EMBL-EBI' },
{ label: 'Annotation', names: 'UniProt · InterPro' },
{ label: 'Structure', names: 'RCSB PDB · AlphaFold' },
{ label: 'Systems', names: 'KEGG · STRING' },
];
const CONFIDENCE_BANDS = [
{ label: 'Very high', dot: 'bg-confidence-very-high' },
{ label: 'High', dot: 'bg-confidence-high' },
{ label: 'Moderate', dot: 'bg-confidence-moderate' },
{ label: 'Low', dot: 'bg-confidence-low' },
];
const REVEAL = { initial: { opacity: 0, y: 28 }, whileInView: { opacity: 1, y: 0 }, viewport: { once: true, margin: '-80px' } };
const PIPELINE = [
{ tag: 'input', label: 'Sequence Input', sub: 'FASTA / accession ID' },
{ tag: 'blast', label: 'BLAST Search', sub: 'EBI BLAST + NCBI' },
{ tag: 'uniprot', label: 'UniProt Lookup', sub: 'Annotation & function' },
{ tag: 'fold', label: 'Structure Prediction', sub: 'AlphaFold 3D viewer' },
{ tag: 'ai', label: 'AI Interpretation', sub: 'Plain-language insight' },
];
const FEATURES = [
{
icon: Database,
title: 'Unified Access',
body: 'NCBI, UniProt, PDB, KEGG, STRING and more — one plain-English query retrieves across every major database simultaneously.',
span: 'md:col-span-2',
},
{
icon: FlowArrow,
title: 'Pipeline Automation',
body: 'BLAST → UniProt → AlphaFold runs sequentially, hands-free. Real-time progress via SSE, results assembled automatically.',
span: 'md:col-span-1',
},
{
icon: Brain,
title: 'AI Interpretation',
body: 'Every result is narrated in plain language. Clinical relevance, evolutionary context, functional insights — streamed live.',
span: 'md:col-span-3',
},
];
export default function LandingPage() {
const heroRef = useRef<HTMLDivElement>(null);
const { scrollYProgress } = useScroll({
target: heroRef,
offset: ['start start', 'end start'],
});
const reduceMotion = useReducedMotion();
// Parallax slides the hero as you scroll — flattened to a cross-fade under
// reduced motion (apple-design §14).
const contentY = useTransform(scrollYProgress, [0, 1], reduceMotion ? ['0%', '0%'] : ['0%', '12%']);
const contentOpacity = useTransform(scrollYProgress, [0, 0.6], [1, 0.2]);
return (
<main className="relative bg-void text-text-primary overflow-x-hidden">
<nav className="fixed top-4 inset-x-0 z-50 flex justify-center px-4 pointer-events-none">
<div className="liquid-glass pointer-events-auto flex w-full max-w-5xl items-center justify-between px-6 py-3.5">
<span className="font-display text-sm font-semibold tracking-tight uppercase">
Syn<span className="text-accent-cyan">teny</span>
</span>
<div className="flex items-center gap-4 lg:gap-6">
<Link href="#features" className="hidden sm:block text-xs text-text-muted hover:text-text-primary transition-colors tracking-wide">
Features
</Link>
<Link href="#pipeline" className="hidden sm:block text-xs text-text-muted hover:text-text-primary transition-colors tracking-wide">
Pipeline
</Link>
<ThemeToggle />
<Link
href="/auth"
className="hidden sm:inline-flex text-xs px-3 lg:px-4 min-h-[44px] items-center rounded-full border border-glass-border text-text-secondary hover:border-accent-cyan/40 hover:text-accent-cyan transition-all"
>
Sign in
</Link>
<Link href="/dashboard" className="btn-primary text-xs px-3 lg:px-4 min-h-[44px] flex items-center">
Start analyzing
</Link>
</div>
</div>
</nav>
<section
ref={heroRef}
className="relative min-h-[100dvh] flex items-center overflow-hidden"
>
<div className="absolute inset-0 z-0 pointer-events-none">
<div
className="absolute inset-0"
style={{
background:
'radial-gradient(ellipse 55% 55% at 78% 45%, rgba(96,165,250,0.10) 0%, transparent 70%), radial-gradient(ellipse 45% 45% at 12% 70%, rgba(74,222,128,0.08) 0%, transparent 70%), radial-gradient(ellipse 42% 42% at 55% 15%, rgba(251,191,36,0.06) 0%, transparent 70%)',
}}
/>
<div className="absolute inset-0 bg-gradient-to-r from-void via-void/55 to-transparent" />
<div className="absolute inset-0 bg-gradient-to-b from-void/70 via-transparent to-void/70" />
</div>
<motion.div
style={{ y: contentY, opacity: contentOpacity }}
className="relative z-10 w-full max-w-6xl mx-auto px-6 py-24"
>
<div className="grid lg:grid-cols-[1.05fr_0.95fr] gap-14 lg:gap-16 items-center">
<div className="max-w-3xl">
<motion.h1
initial={{ opacity: 0, y: 24 }}
animate={{ opacity: 1, y: 0 }}
transition={{ type: 'spring', bounce: 0, duration: 0.7 }}
className="font-display font-bold leading-[0.98] tracking-tight"
style={{ fontSize: 'clamp(2.75rem, 5.5vw, 5.5rem)' }}
>
Stop tab-switching
<br />
<span className="text-accent-cyan">between eight databases.</span>
</motion.h1>
<motion.p
initial={{ opacity: 0, y: 24 }}
animate={{ opacity: 1, y: 0 }}
transition={{ type: 'spring', bounce: 0, duration: 0.7, delay: 0.08 }}
className="text-text-secondary text-lg max-w-[460px] mt-8 leading-relaxed"
>
Paste a sequence. Synteny runs BLAST, annotation, structure and
AI interpretation — assembled on one page, in one query.
</motion.p>
<motion.div
initial={{ opacity: 0, y: 24 }}
animate={{ opacity: 1, y: 0 }}
transition={{ type: 'spring', bounce: 0, duration: 0.7, delay: 0.16 }}
className="flex flex-col sm:flex-row items-start gap-4 mt-10"
>
<Link href="/dashboard" className="btn-primary">
Start analyzing
<ArrowRight size={15} />
</Link>
<Link href="#pipeline" className="btn-ghost">
See the pipeline
</Link>
</motion.div>
<motion.div
initial={{ opacity: 0 }}
animate={{ opacity: 1 }}
transition={{ duration: 0.6, delay: 0.5 }}
className="flex items-center gap-2.5 mt-10 text-[11px] font-mono text-text-muted"
>
<span className="w-1.5 h-1.5 rounded-full bg-accent-cyan animate-pulse" />
<span>No API keys · results streamed live</span>
</motion.div>
</div>
<motion.div
initial={{ opacity: 0, scale: 0.97 }}
animate={{ opacity: 1, scale: 1 }}
transition={{ type: 'spring', bounce: 0, duration: 0.9, delay: 0.2 }}
className="hidden md:block"
>
<div
className="relative rounded-2xl border border-glass-border bg-surface-0/70 overflow-hidden"
style={{ aspectRatio: '4 / 4.3' }}
>
<div className="absolute inset-0">
<DNAHelix className="w-full h-full" />
</div>
<div
className="absolute inset-0 pointer-events-none opacity-40"
style={{ background: 'linear-gradient(180deg, transparent 55%, rgba(5,6,9,0.6) 100%)' }}
/>
<div className="absolute top-3.5 left-4 flex items-center gap-2 font-mono text-[10px] tracking-wider text-text-muted">
<span className="w-1.5 h-1.5 rounded-full bg-accent-cyan animate-pulse" />
DOUBLE HELIX · LIVE
</div>
<div className="absolute bottom-3 left-4 right-4 flex items-center justify-between font-mono text-[10px] tracking-wider text-text-muted">
<span>5′ — 3′</span>
<span>4.2 kb</span>
</div>
</div>
</motion.div>
</div>
</motion.div>
<div className="absolute bottom-9 left-1/2 -translate-x-1/2 z-10 flex flex-col items-center gap-2 opacity-50">
<ChevronDown size={14} className="text-text-muted" />
</div>
</section>
<section className="relative py-14 border-y border-glass-border overflow-hidden">
<div className="absolute inset-0 bg-surface-0/60" />
<div className="relative z-10 marquee-mask">
<div className="marquee-track items-center gap-x-10 gap-y-3">
{[...DATABASES, ...DATABASES].map((db, i) => (
<span
key={`${db}-${i}`}
className="text-sm font-mono text-text-muted hover:text-accent-cyan transition-colors cursor-default select-none"
>
{db}
</span>
))}
</div>
</div>
</section>
<section id="pipeline" className="py-24 px-6 max-w-5xl mx-auto">
<motion.div {...REVEAL} transition={{ duration: 0.45 }} className="text-center mb-16">
<h2 className="font-display text-3xl sm:text-4xl font-bold tracking-tight">
From sequence to insight
</h2>
<p className="text-text-secondary mt-3 max-w-md mx-auto text-sm leading-relaxed">
Five automated stages, zero manual database switching.
</p>
</motion.div>
<div className="relative">
<div className="hidden md:block absolute top-[13px] left-10 right-10 h-px bg-gradient-to-r from-transparent via-glass-border to-transparent" />
<div className="hidden md:block absolute top-[13px] left-10 right-10 h-px pipeline-line" />
<div className="grid grid-cols-1 sm:grid-cols-2 md:grid-cols-5 gap-8 md:gap-4">
{PIPELINE.map(({ tag, label, sub }, i) => (
<motion.div
key={tag}
{...REVEAL}
transition={{ duration: 0.4, delay: i * 0.08 }}
className="relative text-center"
>
<motion.div
className="hidden md:flex w-[26px] h-[26px] rounded-full border border-accent-cyan/40 bg-surface-0 items-center justify-center relative z-10 mx-auto"
initial={{ boxShadow: '0 0 0 0 rgba(74,222,128,0)' }}
whileInView={{ boxShadow: ['0 0 0 0 rgba(74,222,128,0)', '0 0 14px 2px rgba(74,222,128,0.3)', '0 0 0 0 rgba(74,222,128,0)'] }}
viewport={{ once: true, margin: '-80px' }}
transition={{ duration: 0.9, delay: i * 0.25, ease: 'easeInOut' }}
>
<span className="w-[6px] h-[6px] rounded-full bg-accent-cyan/70" />
</motion.div>
<div className="mt-4 md:mt-5">
<p className="text-[10px] font-mono tracking-widest uppercase text-accent-cyan/80">{tag}</p>
<p className="text-sm font-medium text-text-primary mt-1">{label}</p>
<p className="text-[11px] text-text-muted mt-0.5 font-mono">{sub}</p>
</div>
</motion.div>
))}
</div>
</div>
</section>
<section id="results" className="py-24 px-6 max-w-5xl mx-auto">
<motion.div {...REVEAL} transition={{ duration: 0.45 }} className="text-center mb-16">
<h2 className="font-display text-3xl sm:text-4xl font-bold tracking-tight">
What you get back
</h2>
<p className="text-text-secondary mt-3 max-w-md mx-auto text-sm leading-relaxed">
BLAST hits, annotation, structure and AI insight — cross-referenced on one page, exportable as PDF or JSON.
</p>
</motion.div>
<motion.div {...REVEAL} transition={{ duration: 0.45 }}>
<div className="data-card p-6 sm:p-8">
<div className="flex flex-wrap items-center justify-between gap-3 border-b border-glass-border pb-4">
<div className="flex items-center gap-2.5">
<span className="w-2 h-2 rounded-full bg-confidence-very-high" />
<span className="font-mono text-sm text-text-primary">P01308 · Insulin [Homo sapiens]</span>
</div>
<span className="px-2 py-0.5 rounded-full border border-glass-border bg-surface-1 text-[10px] font-mono uppercase tracking-widest text-text-muted">
sample
</span>
</div>
<div className="grid md:grid-cols-2 gap-8 pt-5">
<div>
<p className="text-[10px] font-mono uppercase tracking-widest text-text-muted mb-3">BLAST hits · top 3 of 14</p>
<ul className="flex flex-col gap-2.5">
<li className="flex items-center justify-between gap-4 font-mono text-xs">
<span className="text-text-primary">P01308 · INS_HUMAN</span>
<span className="text-text-secondary">100% · e 0.0</span>
</li>
<li className="flex items-center justify-between gap-4 font-mono text-xs">
<span className="text-text-primary">insulin [mouse]</span>
<span className="text-text-secondary">87% · e 1e-97</span>
</li>
<li className="flex items-center justify-between gap-4 font-mono text-xs">
<span className="text-text-primary">insulin-like INSL3</span>
<span className="text-text-secondary">41% · e 3e-14</span>
</li>
</ul>
</div>
<div>
<p className="text-[10px] font-mono uppercase tracking-widest text-text-muted mb-3">AI interpretation</p>
<p className="font-mono text-[13px] text-text-secondary leading-relaxed">
<span className="text-accent-cyan">> </span>Insulin — reviewed UniProt entry with an experimental
structure. Function, family and disease annotations cross-referenced from the source databases.
</p>
</div>
</div>
<div className="mt-6 flex flex-wrap items-center gap-x-5 gap-y-2 pt-4 border-t border-glass-border">
{CONFIDENCE_BANDS.map((b) => (
<span key={b.label} className="flex items-center gap-1.5 text-[10px] font-mono text-text-muted">
<span className={`w-1.5 h-1.5 rounded-full ${b.dot}`} />
{b.label}
</span>
))}
<span className="ml-auto text-[11px] font-mono text-text-muted">NCBI · UniProt · PDB · AlphaFold</span>
</div>
</div>
</motion.div>
</section>
<section id="features" className="py-24 px-6 max-w-5xl mx-auto">
<motion.div {...REVEAL} transition={{ duration: 0.45 }} className="mb-16">
<h2 className="font-display text-3xl sm:text-4xl font-bold tracking-tight">
All your databases, one query
</h2>
<p className="text-text-secondary mt-3 max-w-md mx-auto text-sm leading-relaxed">
One query retrieves across every major database simultaneously — results cross-referenced on a single page.
</p>
</motion.div>
<div className="grid grid-cols-1 md:grid-cols-3 gap-5">
{FEATURES.map((f, i) => {
const Icon = f.icon;
const wide = f.span === 'md:col-span-2';
const full = f.span === 'md:col-span-3';
return (
<motion.div
key={f.title}
{...REVEAL}
transition={{ duration: 0.4, delay: (i % 3) * 0.08 }}
className={`${f.span}`}
>
<TiltCard
className={`glass-card p-8 cursor-default h-full ${full ? 'flex flex-col md:flex-row md:items-center gap-8' : ''}`}
>
<div
className={`w-10 h-10 rounded-xl flex items-center justify-center bg-accent-cyan/10 border border-accent-cyan/20 shrink-0 ${full ? 'mb-0' : 'mb-6'}`}
>
<Icon size={18} className="text-accent-cyan" weight="regular" />
</div>
<div className={wide ? 'grid lg:grid-cols-2 gap-8 items-start' : ''}>
<div>
<h3 className={`font-display font-semibold mb-2 text-text-primary ${wide ? 'text-xl' : 'text-base'}`}>
{f.title}
</h3>
<p className="text-sm text-text-secondary leading-relaxed max-w-[46ch]">
{f.body}
</p>
</div>
{wide && (
<div className="flex flex-col gap-2 lg:pt-1">
{DB_GROUPS.map((g) => (
<div key={g.label} className="flex items-center gap-2">
<span className="text-[10px] font-mono uppercase tracking-widest text-text-muted w-20 shrink-0">
{g.label}
</span>
<span className="px-2.5 py-1 rounded-lg border border-glass-border bg-surface-1 text-[11px] font-mono text-text-secondary">
{g.names}
</span>
</div>
))}
</div>
)}
{full && (
<div className="min-w-0 md:ml-auto w-full">
<p className="font-mono text-[13px] text-text-secondary leading-relaxed">
<span className="text-accent-cyan">> </span>docking · <span className="text-text-primary">7 poses</span> scored against target pocket
<span className="inline-block w-[2px] h-3 bg-accent-cyan/70 ml-1 animate-blink align-middle" />
</p>
<p className="mt-3 text-sm text-text-secondary leading-relaxed max-w-[46ch]">
Best pose: binding affinity −8.4 kcal/mol, ligand efficiency 0.31 — narrated in plain language alongside the raw AutoDock Vina output.
</p>
<p className="mt-3 text-[11px] font-mono text-text-muted">
engine · AutoDock Vina · CPU-based, no GPU required
</p>
</div>
)}
</div>
<div className={`mt-6 h-px rounded-full bg-gradient-to-r from-accent-cyan/25 to-transparent ${full ? 'md:hidden' : ''}`} />
</TiltCard>
</motion.div>
);
})}
</div>
</section>
<section className="py-32 px-6 relative overflow-hidden">
<div
className="absolute inset-0 pointer-events-none"
style={{
background: 'radial-gradient(ellipse 60% 60% at 50% 50%, rgba(96,165,250,0.06) 0%, transparent 70%), radial-gradient(ellipse 40% 40% at 68% 62%, rgba(52,211,153,0.04) 0%, transparent 70%)',
}}
/>
<div className="relative z-10 text-center max-w-xl mx-auto">
<h2 className="font-display text-3xl sm:text-4xl font-bold tracking-tight mb-5">
Ready to decode your sequences?
</h2>
<p className="text-text-secondary mb-4 leading-relaxed">
Free to start. No API keys required to run your first analysis.
</p>
<p className="text-sm text-text-muted mb-10 font-mono">
Your sequences stay yours — never shared or used beyond the analysis you ask for.
</p>
<Link href="/dashboard" className="btn-primary text-base px-8 py-4">
Start analyzing
<ArrowRight size={17} />
</Link>
</div>
</section>
<footer className="border-t border-glass-border py-8 px-8 flex flex-col sm:flex-row items-center justify-between gap-4">
<span className="text-xs text-text-muted">
Synteny · Built at Jamia Millia Islamia
</span>
<div className="flex items-center gap-6">
<Link href="/auth" className="text-xs text-text-muted hover:text-text-primary transition-colors">
Sign in
</Link>
<span className="text-xs text-text-muted">© 2026</span>
</div>
</footer>
<JsonLd
data={{
'@context': 'https://schema.org',
'@type': 'WebPage',
'@id': WEBPAGE_ID,
url: `${SITE_URL}/`,
name: 'Synteny — One interface for every bioinformatics tool',
isPartOf: { '@id': WEBSITE_ID },
about: { '@id': SOFTWARE_ID },
mainEntity: {
'@type': 'SoftwareApplication',
'@id': SOFTWARE_ID,
name: SITE_NAME,
applicationCategory: 'ScienceApplication',
applicationSubCategory: 'Bioinformatics',
operatingSystem: 'Web',
url: `${SITE_URL}/`,
description:
'Runs BLAST, UniProt annotation, AlphaFold structure prediction, molecular docking and AI interpretation from a single sequence input, with results cross-referenced on one page.',
offers: {
'@type': 'Offer',
price: '0',
priceCurrency: 'USD',
description: 'Free to start, no API key required',
},
featureList: [
'BLAST search (EBI + NCBI)',
'UniProt annotation lookup',
'AlphaFold 3D structure prediction',
'Molecular docking (AutoDock Vina)',
'Phylogenetic tree construction (NJ, UPGMA, Maximum Likelihood)',
'AI-generated plain-language interpretation',
'PDF/JSON export',
],
creator: { '@id': ORG_ID },
},
}}
/>
<JsonLd
data={{
'@context': 'https://schema.org',
'@type': 'HowTo',
name: 'How Synteny analyzes a sequence',
description: 'Five automated stages from raw sequence to AI-interpreted results.',
step: [
{ '@type': 'HowToStep', position: 1, name: 'Sequence Input', text: 'Paste a FASTA sequence or accession ID.' },
{ '@type': 'HowToStep', position: 2, name: 'BLAST Search', text: 'Runs EBI BLAST and NCBI BLAST against reference databases.' },
{ '@type': 'HowToStep', position: 3, name: 'UniProt Lookup', text: 'Retrieves functional annotation from UniProt.' },
{ '@type': 'HowToStep', position: 4, name: 'Structure Prediction', text: 'AlphaFold structure is fetched and rendered in an interactive 3D viewer.' },
{ '@type': 'HowToStep', position: 5, name: 'AI Interpretation', text: 'Results are synthesized into a plain-language summary.' },
],
}}
/>
</main>
);
}
|