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import { useCallback, useEffect, useMemo, useRef, useState } from 'react'
import { MagnifyingGlass as Search } from '@phosphor-icons/react'
import { ClaySegmented } from '@/components/ui/ClaySegmented'
import { AlignmentStatsBar } from '@/components/alignment/AlignmentStatsBar'
import { AlignmentBlock } from '@/components/alignment/AlignmentBlock'
import { computeAlignmentStats, parseAlignedFasta } from '@/lib/alignment-stats'
import { useTheme } from '@/contexts/theme'
import { cssColor } from '@/lib/theme-canvas'
// βββ Types ββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
interface TreeNode {
id: number
name: string
length: number
bootstrap: number | null
children: TreeNode[]
parent: TreeNode | null
x: number
y: number
px: number
py: number
angle?: number
radius?: number
}
type Layout = 'rectangular' | 'circular'
export interface PhyloTreeViewerProps {
newick: string
method?: 'nj' | 'ml' | 'upgma'
alignment?: string
sequenceType?: 'protein' | 'dna'
}
// βββ Newick parser ββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
function parseNewick(s: string): TreeNode {
let nextId = 0
const makeNode = (): TreeNode => ({
id: nextId++, name: '', length: 0, bootstrap: null,
children: [], parent: null,
x: 0, y: 0, px: 0, py: 0,
})
const stack: TreeNode[] = []
let cur: TreeNode = makeNode()
let i = 0
const n = s.length
while (i < n) {
const ch = s[i]
if (ch === '(') {
const child = makeNode()
child.px = cur.px; child.py = cur.py
cur.children.push(child)
stack.push(cur)
child.parent = cur
cur = child
i++
} else if (ch === ',') {
const parent = stack[stack.length - 1]
const sibling = makeNode()
parent.children.push(sibling)
sibling.parent = parent
cur = sibling
i++
} else if (ch === ')') {
cur = stack.pop()!
i++
while (i < n && s[i] === ' ') i++
if (i < n && s[i] !== ':' && s[i] !== ',' && s[i] !== ')' && s[i] !== ';' && s[i] !== '[') {
const [label, ni] = readToken(s, i)
i = ni
const num = parseFloat(label)
if (!isNaN(num) && label.trim() !== '') {
cur.bootstrap = num
} else {
cur.name = label
}
}
if (i < n && s[i] === '[') {
while (i < n && s[i] !== ']') i++
i++
}
if (i < n && s[i] === ':') {
i++
const [lenStr, ni] = readNumber(s, i)
cur.length = parseFloat(lenStr) || 0
i = ni
}
} else if (ch === ':') {
i++
const [lenStr, ni] = readNumber(s, i)
cur.length = parseFloat(lenStr) || 0
i = ni
} else if (ch === ';' || ch === '\n' || ch === '\r') {
i++
} else {
if (ch === "'") {
i++
let name = ''
while (i < n && s[i] !== "'") { name += s[i]; i++ }
cur.name = name
i++
} else {
const [name, ni] = readToken(s, i)
cur.name = name
i = ni
}
}
}
return cur
}
function readToken(s: string, i: number): [string, number] {
let tok = ''
while (i < s.length && !'(),;:['.includes(s[i])) { tok += s[i]; i++ }
return [tok.trim(), i]
}
function readNumber(s: string, i: number): [string, number] {
let tok = ''
while (i < s.length && '0123456789.-eE+'.includes(s[i])) { tok += s[i]; i++ }
return [tok, i]
}
// βββ Tree helpers βββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
function countLeaves(n: TreeNode): number {
if (!n.children.length) return 1
return n.children.reduce((s, c) => s + countLeaves(c), 0)
}
function pruneTree(node: TreeNode, collapsed: Set<number>): TreeNode {
if (collapsed.has(node.id) && node.children.length > 0) {
return { ...node, id: node.id, children: [], name: `+${countLeaves(node)}`, parent: null }
}
const children = node.children.map(c => pruneTree(c, collapsed))
const pruned = { ...node, children, parent: null }
children.forEach(c => { c.parent = pruned })
return pruned
}
function computePathSet(nodes: TreeNode[], targetId: number | null): Set<number> {
if (targetId === null) return new Set()
const map = new Map<number, TreeNode>()
for (const n of nodes) map.set(n.id, n)
const path = new Set<number>()
let id: number | undefined = targetId
while (id !== undefined) {
path.add(id)
const node = map.get(id)
id = node?.parent?.id
}
return path
}
function findNodeById(nodes: TreeNode[], id: number): TreeNode | null {
for (const n of nodes) {
if (n.id === id) return n
if (n.children.length) {
const found = findNodeById(n.children, id)
if (found) return found
}
}
return null
}
function clamp(v: number, min: number, max: number) {
return Math.max(min, Math.min(max, v))
}
// βββ Rectangular layout βββββββββββββββββββββββββββββββββββββββββββββββββββββββ
const SVG_W = 720
const SVG_PAD = { top: 20, right: 160, bottom: 40, left: 20 }
function buildRectangularLayout(root: TreeNode, collapsed: Set<number>):
{ nodes: TreeNode[]; height: number; maxDepth: number; rootNode: TreeNode } {
const pruned = pruneTree(root, collapsed)
const nodes: TreeNode[] = []
let leafIdx = 0
const totalLeaves = countLeaves(pruned)
const rowH = Math.max(18, Math.min(26, 600 / totalLeaves))
const drawH = totalLeaves * rowH
const drawW = SVG_W - SVG_PAD.left - SVG_PAD.right
function hasBranchLengths(n: TreeNode): boolean {
return n.length > 0 || n.children.some(hasBranchLengths)
}
const useLengths = hasBranchLengths(pruned)
function maxDepth(n: TreeNode, d: number): number {
if (!n.children.length) return d + n.length
return Math.max(...n.children.map(c => maxDepth(c, d + n.length)))
}
const totalDepth = useLengths ? maxDepth(pruned, 0) : 0
function getMaxDepthSteps(n: TreeNode, d = 0): number {
if (!n.children.length) return d
return Math.max(...n.children.map(c => getMaxDepthSteps(c, d + 1)))
}
function assignPositions(n: TreeNode, depth: number, px: number, py: number): void {
nodes.push(n)
const x = useLengths && totalDepth > 0
? SVG_PAD.left + (depth / totalDepth) * drawW
: SVG_PAD.left + depth * (drawW / (getMaxDepthSteps(pruned) || 1))
n.px = px; n.py = py
if (!n.children.length) {
n.x = x
n.y = SVG_PAD.top + leafIdx * rowH + rowH / 2
leafIdx++
} else {
n.children.forEach(c => assignPositions(c, depth + (useLengths ? c.length : 1), x, 0))
n.y = (n.children[0].y + n.children[n.children.length - 1].y) / 2
n.x = x
n.children.forEach(c => { c.px = n.x; c.py = n.y })
}
}
assignPositions(pruned, 0, SVG_PAD.left, SVG_PAD.top + drawH / 2)
pruned.px = pruned.x; pruned.py = pruned.y
return { nodes, height: drawH + SVG_PAD.top + SVG_PAD.bottom, maxDepth: totalDepth, rootNode: pruned }
}
// βββ Circular layout ββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
const CIRC_R = 280
const CIRC_CX = 380
const CIRC_CY = 380
const CIRC_SIZE = 760
function buildCircularLayout(root: TreeNode, collapsed: Set<number>):
{ nodes: TreeNode[]; height: number; maxDepth: number; rootNode: TreeNode } {
const pruned = pruneTree(root, collapsed)
const nodes: TreeNode[] = []
const total = countLeaves(pruned)
let leafIdx = 0
function hasBranchLengths(n: TreeNode): boolean {
return n.length > 0 || n.children.some(hasBranchLengths)
}
const useLengths = hasBranchLengths(pruned)
function maxCumDist(n: TreeNode, d: number): number {
if (!n.children.length) return d + (useLengths ? n.length : 1)
return Math.max(...n.children.map(c => maxCumDist(c, d + (useLengths ? c.length : 1))))
}
const maxDist = maxCumDist(pruned, 0) || 1
function assignAngles(n: TreeNode): number {
if (!n.children.length) {
n.angle = (leafIdx / total) * 2 * Math.PI
leafIdx++
return n.angle!
}
const childAngles = n.children.map(assignAngles)
n.angle = (Math.min(...childAngles) + Math.max(...childAngles)) / 2
return n.angle!
}
function assignRadii(n: TreeNode, cumDist: number): void {
n.radius = (cumDist / maxDist) * CIRC_R
n.children.forEach(c => assignRadii(c, cumDist + (useLengths ? c.length : 1)))
}
function toCartesian(n: TreeNode, parent: TreeNode | null): void {
nodes.push(n)
n.x = CIRC_CX + n.radius! * Math.cos(n.angle!)
n.y = CIRC_CY + n.radius! * Math.sin(n.angle!)
n.px = parent ? parent.x : n.x
n.py = parent ? parent.y : n.y
n.children.forEach(c => toCartesian(c, n))
}
assignAngles(pruned)
assignRadii(pruned, 0)
toCartesian(pruned, null)
return { nodes, height: CIRC_SIZE, maxDepth: 0, rootNode: pruned }
}
// βββ Bootstrap colour scale ββββββββββββββββββββββββββββββββββββββββββββββββββββ
function bootstrapColour(val: number): string {
if (val >= 90) return '#4ADE80'
if (val >= 70) return '#a3e635'
if (val >= 50) return '#fb923c'
return '#f87171'
}
// βββ SVG sub-renderers ββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
function RectangularTree({
nodes, svgH, maxDepth,
pathSet, selectedId, hoveredId,
onNodeHover, onNodeClick, onNodeDoubleClick,
}: {
nodes: TreeNode[]; svgH: number; maxDepth: number
pathSet: Set<number>; selectedId: number | null; hoveredId: number | null
onNodeHover: (id: number | null) => void; onNodeClick: (id: number) => void; onNodeDoubleClick: (id: number) => void
}) {
const hasHover = hoveredId !== null
const drawW = SVG_W - SVG_PAD.left - SVG_PAD.right
return (
<>
{nodes.map((n, i) => {
if (n.px === n.x && n.py === n.y) return null
const onPath = pathSet.has(n.id)
const dim = hasHover && !onPath
const bright = hasHover && onPath
return (
<g key={`b-${i}`}>
<line x1={n.px} y1={n.py} x2={n.px} y2={n.y}
stroke={bright ? '#4ADE80' : '#334155'}
strokeWidth={bright ? 2 : dim ? 0.5 : 1.2}
opacity={dim ? 0.12 : 1} />
<line x1={n.px} y1={n.y} x2={n.x} y2={n.y}
stroke={bright ? '#4ADE80' : '#475569'}
strokeWidth={bright ? 2.5 : dim ? 0.5 : 1.5}
opacity={dim ? 0.12 : 1} />
{n.length > 0.001 && (
<text x={(n.px + n.x) / 2} y={n.y - 5} fontSize={8}
fill={bright ? '#4ADE80' : '#64748b'}
opacity={dim ? 0.12 : 0.8}
textAnchor="middle" fontFamily="sans-serif">
{n.length.toFixed(4)}
</text>
)}
</g>
)
})}
{nodes.map((n, i) => {
const isLeaf = n.children.length === 0
const onPath = pathSet.has(n.id)
const dim = hasHover && !onPath
const bright = hasHover && onPath
const isSelected = selectedId === n.id
const blTip = n.length > 0 ? `branch length: ${n.length.toFixed(5)}` : ''
return (
<g key={`n-${i}`}
style={{ cursor: 'pointer' }}
onMouseEnter={() => onNodeHover(n.id)}
onMouseLeave={() => onNodeHover(null)}
onClick={(e) => { e.stopPropagation(); onNodeClick(n.id) }}
onDoubleClick={(e) => { e.stopPropagation(); onNodeDoubleClick(n.id) }}
>
{isLeaf ? (
<>
<circle cx={n.x} cy={n.y} r={isSelected ? 5 : 3}
fill="#4ADE80"
opacity={dim ? 0.12 : isSelected ? 1 : 0.8}
stroke={isSelected ? '#fff' : 'none'}
strokeWidth={isSelected ? 1.5 : 0} />
<text x={n.x + 8} y={n.y + 4} fontSize={11}
fill={bright ? '#4ADE80' : '#94a3b8'}
opacity={dim ? 0.12 : 1}
fontFamily="var(--font-geist-mono), monospace"
fontWeight={isSelected ? 'bold' : 'normal'}>
{n.name}
</text>
<title>{n.name}{blTip ? ` Β· ${blTip}` : ''}</title>
</>
) : (
<>
<circle cx={n.x} cy={n.y} r={isSelected ? 7 : 5}
fill={dim ? '#1e293b' : isSelected ? '#4ADE80' : '#1e293b'}
stroke={isSelected ? cssColor('--tree-selected', '#FFFFFF') : bright ? '#4ADE80' : '#475569'}
strokeWidth={isSelected ? 2 : bright ? 2 : 1.5}
opacity={dim ? 0.12 : 0.85} />
{n.bootstrap !== null && n.bootstrap >= 50 && (
<text x={n.x - 4} y={n.y - 7} fontSize={9}
fill={bootstrapColour(n.bootstrap)} textAnchor="end"
fontFamily="sans-serif" fontWeight="bold"
opacity={dim ? 0.12 : 1}>
{Math.round(n.bootstrap)}
</text>
)}
<text x={n.x} y={n.y + 4} fontSize={7}
fill={bright ? '#4ADE80' : '#64748b'}
opacity={dim ? 0.12 : 0.7}
textAnchor="middle" fontFamily="sans-serif">
{n.name || `N${i}`}
</text>
<title>Node {n.name || `N${i}`}{blTip ? ` Β· ${blTip}` : ''}{n.bootstrap !== null ? ` Β· bootstrap: ${n.bootstrap}` : ''}</title>
</>
)}
</g>
)
})}
{maxDepth > 0 && (() => {
const scaleVal = parseFloat((maxDepth / 5).toPrecision(1))
const scaleW = (scaleVal / maxDepth) * drawW
const bx = SVG_PAD.left
const by = svgH - SVG_PAD.bottom + 10
return (
<g>
<line x1={bx} y1={by} x2={bx + scaleW} y2={by} stroke="#64748b" strokeWidth={1.5} />
<line x1={bx} y1={by - 4} x2={bx} y2={by + 4} stroke="#64748b" strokeWidth={1.5} />
<line x1={bx + scaleW} y1={by - 4} x2={bx + scaleW} y2={by + 4} stroke="#64748b" strokeWidth={1.5} />
<text x={bx + scaleW / 2} y={by + 14} fontSize={10} fill="#64748b"
textAnchor="middle" fontFamily="sans-serif">
{scaleVal} substitutions/site
</text>
</g>
)
})()}
</>
)
}
function CircularTree({
nodes, pathSet, selectedId, hoveredId,
onNodeHover, onNodeClick, onNodeDoubleClick,
}: {
nodes: TreeNode[]; pathSet: Set<number>; selectedId: number | null; hoveredId: number | null
onNodeHover: (id: number | null) => void; onNodeClick: (id: number) => void; onNodeDoubleClick: (id: number) => void
}) {
const hasHover = hoveredId !== null
return (
<>
{nodes.map((n, i) => {
if (n.px === n.x && n.py === n.y) return null
const onPath = pathSet.has(n.id)
const dim = hasHover && !onPath
const bright = hasHover && onPath
const midX = (n.px + n.x) / 2
const midY = (n.py + n.y) / 2
return (
<g key={`b-${i}`}>
<line x1={n.px} y1={n.py} x2={n.x} y2={n.y}
stroke={bright ? '#4ADE80' : '#475569'}
strokeWidth={bright ? 2.5 : dim ? 0.5 : 1.4}
opacity={dim ? 0.12 : 1} />
{n.length > 0.001 && (
<text x={midX} y={midY - 4} fontSize={7}
fill={bright ? '#4ADE80' : '#64748b'}
opacity={dim ? 0.12 : 0.8}
textAnchor="middle" fontFamily="sans-serif">
{n.length.toFixed(4)}
</text>
)}
</g>
)
})}
{nodes.filter(n => n.children.length > 0).map((n, i) => {
const r = n.radius!
if (r < 1 || n.children.length < 2) return null
const onPath = pathSet.has(n.id)
const dim = hasHover && !onPath
const bright = hasHover && onPath
const angles = n.children.map(c => c.angle!)
const a0 = Math.min(...angles)
const a1 = Math.max(...angles)
const x0 = CIRC_CX + r * Math.cos(a0)
const y0 = CIRC_CY + r * Math.sin(a0)
const x1 = CIRC_CX + r * Math.cos(a1)
const y1 = CIRC_CY + r * Math.sin(a1)
const largeArc = (a1 - a0) > Math.PI ? 1 : 0
return (
<path key={`arc-${i}`}
d={`M ${x0} ${y0} A ${r} ${r} 0 ${largeArc} 1 ${x1} ${y1}`}
fill="none" stroke={bright ? '#4ADE80' : '#334155'}
strokeWidth={bright ? 2 : dim ? 0.5 : 1.2}
opacity={dim ? 0.12 : 1} />
)
})}
{nodes.map((n, i) => {
const isLeaf = n.children.length === 0
const angle = n.angle ?? 0
const deg = (angle * 180) / Math.PI
const flip = deg > 90 && deg < 270
const labelX = CIRC_CX + (n.radius! + 10) * Math.cos(angle)
const labelY = CIRC_CY + (n.radius! + 10) * Math.sin(angle)
const onPath = pathSet.has(n.id)
const dim = hasHover && !onPath
const bright = hasHover && onPath
const isSelected = selectedId === n.id
const blTip = n.length > 0 ? `branch length: ${n.length.toFixed(5)}` : ''
return (
<g key={`n-${i}`}
transform={`rotate(${deg - (flip ? 180 : 0)}, ${CIRC_CX + n.radius! * Math.cos(angle)}, ${CIRC_CY + n.radius! * Math.sin(angle)})`}
style={{ cursor: 'pointer' }}
onMouseEnter={() => onNodeHover(n.id)}
onMouseLeave={() => onNodeHover(null)}
onClick={(e) => { e.stopPropagation(); onNodeClick(n.id) }}
onDoubleClick={(e) => { e.stopPropagation(); onNodeDoubleClick(n.id) }}
>
{isLeaf ? (
<>
<circle cx={n.x} cy={n.y} r={isSelected ? 5 : 3}
fill="#4ADE80"
opacity={dim ? 0.12 : isSelected ? 1 : 0.8}
stroke={isSelected ? '#fff' : 'none'}
strokeWidth={isSelected ? 1.5 : 0} />
<text
x={labelX} y={labelY + 4}
fontSize={10}
fill={bright ? '#4ADE80' : '#94a3b8'}
opacity={dim ? 0.12 : 1}
fontFamily="var(--font-geist-mono), monospace"
fontWeight={isSelected ? 'bold' : 'normal'}
textAnchor={flip ? 'end' : 'start'}
transform={`rotate(${-(deg - (flip ? 180 : 0))}, ${labelX}, ${labelY})`}
>
{n.name}
</text>
<title>{n.name}{blTip ? ` Β· ${blTip}` : ''}</title>
</>
) : (
<>
<circle cx={n.x} cy={n.y} r={isSelected ? 7 : 5}
fill={dim ? '#1e293b' : isSelected ? '#4ADE80' : '#1e293b'}
stroke={isSelected ? cssColor('--tree-selected', '#FFFFFF') : bright ? '#4ADE80' : '#475569'}
strokeWidth={isSelected ? 2 : bright ? 2 : 1.5}
opacity={dim ? 0.12 : 0.85} />
{n.bootstrap !== null && n.bootstrap >= 50 && (
<text x={n.x} y={n.y - 7} fontSize={8}
fill={bootstrapColour(n.bootstrap)} textAnchor="middle" fontWeight="bold"
opacity={dim ? 0.12 : 1}>
{Math.round(n.bootstrap)}
</text>
)}
<text x={n.x} y={n.y + 4} fontSize={6}
fill={bright ? '#4ADE80' : '#64748b'}
opacity={dim ? 0.12 : 0.7}
textAnchor="middle" fontFamily="sans-serif">
{n.name || `N${i}`}
</text>
<title>Node {n.name || `N${i}`}{blTip ? ` Β· ${blTip}` : ''}{n.bootstrap !== null ? ` Β· bootstrap: ${n.bootstrap}` : ''}</title>
</>
)}
</g>
)
})}
</>
)
}
// βββ Node info panel ββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
function NodeInfoPanel({ node, allNodes }: { node: TreeNode; allNodes: TreeNode[] }) {
const isLeaf = node.children.length === 0
const leavesInSubtree = isLeaf ? 1 : countLeaves(node)
const depth = (() => {
let d = 0; let cur: TreeNode | null = node.parent
while (cur) { d++; cur = cur.parent }
return d
})()
const leafName = isLeaf ? (node.name || '').split('|').pop()?.split('_')[0] || node.name : ''
const isValidAccession = leafName.length >= 4 && /^[A-Z0-9_]+$/.test(leafName)
return (
<div className="data-card p-4 space-y-2 text-sm">
<div className="flex items-center justify-between">
<span className="text-text-primary font-medium">
{isLeaf ? node.name || 'Leaf' : 'Internal Node'}
</span>
<span className="text-text-secondary text-xs">
{isLeaf ? 'leaf' : 'hub'} Β· depth {depth}
</span>
</div>
<div className="grid grid-cols-2 gap-2 text-xs">
<div>
<span className="text-text-secondary mr-1">Branch length:</span>
<span className="text-accent-cyan font-mono">{node.length.toFixed(5)}</span>
</div>
{node.bootstrap !== null && (
<div>
<span className="text-text-secondary mr-1">Bootstrap:</span>
<span className="font-mono" style={{ color: bootstrapColour(node.bootstrap) }}>
{node.bootstrap}
</span>
</div>
)}
{!isLeaf && (
<div>
<span className="text-text-secondary mr-1">Subtree leaves:</span>
<span className="text-text-primary font-mono">{leavesInSubtree}</span>
</div>
)}
<div>
<span className="text-text-secondary mr-1">Node ID:</span>
<span className="text-text-primary font-mono">{node.id}</span>
</div>
</div>
{isLeaf && isValidAccession && (
<div className="pt-2 border-t border-glass-border flex items-center justify-end gap-2">
<a href={`https://www.ncbi.nlm.nih.gov/protein/${leafName}`} target="_blank" rel="noreferrer"
className="text-xs text-accent-cyan hover:underline">View on NCBI</a>
<button onClick={() => window.open(`/analyze/blast?sequence=${leafName}`, '_blank')}
className="flex items-center gap-1 px-2.5 py-1 rounded bg-accent-cyan/10 text-accent-cyan text-xs font-medium hover:bg-accent-cyan/20 transition">
<Search className="w-3 h-3" /> BLAST ortholog (F6)
</button>
</div>
)}
</div>
)
}
// βββ Export helpers βββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
function downloadBlob(blob: Blob, filename: string) {
const url = URL.createObjectURL(blob)
const a = document.createElement('a')
a.href = url; a.download = filename; a.click()
URL.revokeObjectURL(url)
}
function exportSVG(svgEl: SVGSVGElement, filename: string) {
const src = '<?xml version="1.0" encoding="UTF-8"?>\n' +
new XMLSerializer().serializeToString(svgEl)
downloadBlob(new Blob([src], { type: 'image/svg+xml' }), filename)
}
function exportPNG(svgEl: SVGSVGElement, filename: string) {
const { width, height } = svgEl.viewBox.baseVal
const scale = 2
const canvas = Object.assign(document.createElement('canvas'), {
width: width * scale, height: height * scale,
})
const ctx = canvas.getContext('2d')!
const img = new Image()
const data = 'data:image/svg+xml;base64,' +
btoa(unescape(encodeURIComponent(new XMLSerializer().serializeToString(svgEl))))
img.onload = () => {
ctx.fillStyle = cssColor('--tree-canvas', '#06060B')
ctx.fillRect(0, 0, canvas.width, canvas.height)
ctx.scale(scale, scale)
ctx.drawImage(img, 0, 0)
canvas.toBlob(b => b && downloadBlob(b, filename), 'image/png')
}
img.src = data
}
// βββ Method badge βββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
const METHOD_META = {
nj: { label: 'Neighbor-Joining', colour: 'text-accent-cyan border-accent-cyan/40 bg-accent-cyan/10' },
ml: { label: 'Maximum Likelihood', colour: 'text-violet-400 border-violet-400/40 bg-violet-400/10' },
upgma: { label: 'UPGMA', colour: 'text-amber-400 border-amber-400/40 bg-amber-400/10' },
}
// βββ Main component βββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
export default function PhyloTreeViewer({
newick,
method,
alignment,
sequenceType = 'protein',
}: PhyloTreeViewerProps) {
const [layout, setLayout] = useState<Layout>('rectangular')
const [showAlignment, setShowAln] = useState(false)
const [showRaw, setShowRaw] = useState(false)
const [hoveredId, setHoveredId] = useState<number | null>(null)
const [selectedId, setSelectedId] = useState<number | null>(null)
const [collapsedIds, setCollapsedIds] = useState<Set<number>>(new Set())
const { theme } = useTheme()
// Resolved at render so toggling the theme re-reads the tokens (re-render below).
const treeCanvas = cssColor('--tree-canvas', theme === 'light' ? '#FFFFFF' : '#06060B')
const alignmentStats = useMemo(
() => (alignment ? computeAlignmentStats(parseAlignedFasta(alignment).seqs) : null),
[alignment],
)
// zoom / pan
const [transform, setTransform] = useState({ scale: 1, x: 0, y: 0 })
const [isDragging, setIsDragging] = useState(false)
const dragRef = useRef({ startX: 0, startY: 0, startS: 1, startTx: 0, startTy: 0, moved: false })
const svgRef = useRef<SVGSVGElement>(null)
const treeData = useMemo(() => {
try {
const root = parseNewick(newick)
if (layout === 'rectangular') {
return { ...buildRectangularLayout(root, collapsedIds), error: null as string | null }
} else {
return { ...buildCircularLayout(root, collapsedIds), error: null as string | null }
}
} catch (e) {
return { nodes: [], height: 400, maxDepth: 0, rootNode: null as TreeNode | null, error: String(e) }
}
}, [newick, layout, collapsedIds])
const pathSet = useMemo(() => computePathSet(treeData.nodes, hoveredId), [hoveredId, treeData.nodes])
const selectedNode = useMemo(() => {
if (selectedId === null) return null
return findNodeById(treeData.nodes, selectedId)
}, [selectedId, treeData.nodes])
const filename = `phylo_tree_${method ?? 'tree'}`
const handleExportSVG = useCallback(() => {
if (svgRef.current) exportSVG(svgRef.current, `${filename}.svg`)
}, [filename])
const handleExportPNG = useCallback(() => {
if (svgRef.current) exportPNG(svgRef.current, `${filename}.png`)
}, [filename])
const handleExportNewick = useCallback(() => {
downloadBlob(new Blob([newick], { type: 'text/plain' }), `${filename}.nwk`)
}, [newick, filename])
// ββ Zoom / pan event handlers ββββββββββββββββββββββββββββββββββββββββββββββ
const handleWheel = useCallback((e: WheelEvent) => {
e.preventDefault()
const svg = svgRef.current
if (!svg) return
const rect = svg.getBoundingClientRect()
const mx = e.clientX - rect.left
const my = e.clientY - rect.top
const delta = e.deltaY > 0 ? 0.88 : 1 / 0.88
const newScale = clamp(transform.scale * delta, 0.08, 12)
const ratio = newScale / transform.scale
setTransform({
scale: newScale,
x: mx - (mx - transform.x) * ratio,
y: my - (my - transform.y) * ratio,
})
}, [transform])
// Attach non-passive wheel listener so e.preventDefault() blocks page scroll
useEffect(() => {
const el = svgRef.current
if (!el) return
el.addEventListener('wheel', handleWheel, { passive: false })
return () => el.removeEventListener('wheel', handleWheel)
}, [handleWheel])
const resetView = useCallback(() => {
setTransform({ scale: 1, x: 0, y: 0 })
}, [])
const handleMouseDown = useCallback((e: React.MouseEvent<SVGSVGElement>) => {
if (e.button !== 0) return
setIsDragging(true)
dragRef.current = {
startX: e.clientX, startY: e.clientY,
startS: transform.scale, startTx: transform.x, startTy: transform.y,
moved: false,
}
}, [transform])
const handleMouseMove = useCallback((e: React.MouseEvent<SVGSVGElement>) => {
if (!isDragging) return
const drag = dragRef.current
const dx = e.clientX - drag.startX
const dy = e.clientY - drag.startY
if (Math.abs(dx) > 3 || Math.abs(dy) > 3) drag.moved = true
setTransform(t => ({ ...t, x: drag.startTx + dx, y: drag.startTy + dy }))
}, [isDragging])
const handleMouseUp = useCallback(() => {
setIsDragging(false)
}, [])
// ββ Node interaction handlers βββββββββββββββββββββββββββββββββββββββββββββββ
const handleNodeHover = useCallback((id: number | null) => {
setHoveredId(id)
}, [])
const handleNodeClick = useCallback((id: number) => {
setIsDragging(false)
if (dragRef.current.moved) return
setSelectedId(prev => prev === id ? null : id)
}, [])
const handleNodeDoubleClick = useCallback((id: number) => {
setCollapsedIds(prev => {
const next = new Set(prev)
if (next.has(id)) next.delete(id); else next.add(id)
return next
})
setSelectedId(null)
}, [])
const handleSvgClick = useCallback(() => {
setSelectedId(null)
setHoveredId(null)
}, [])
const expandAll = useCallback(() => setCollapsedIds(new Set()), [])
const collapseAllInternal = useCallback(() => {
setCollapsedIds(new Set(treeData.nodes.filter(n => n.children.length > 0).map(n => n.id)))
}, [treeData.nodes])
// ββ Error state βββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
if (treeData.error) {
return (
<div className="glass-card p-6 text-error">
<p className="font-medium mb-1">Failed to parse Newick string</p>
<pre className="text-xs opacity-70 overflow-auto">{treeData.error}</pre>
<pre className="text-xs opacity-40 mt-2 overflow-auto">{newick.slice(0, 200)}</pre>
</div>
)
}
// ββ Render ββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
return (
<div className="space-y-4">
{/* Toolbar */}
<div className="flex flex-wrap items-center gap-3">
{method && (
<span className={`text-xs px-2.5 py-1 rounded-full border font-medium ${METHOD_META[method].colour}`}>
{METHOD_META[method].label}
</span>
)}
<ClaySegmented
options={[
{ value: 'rectangular', label: 'Rectangular' },
{ value: 'circular', label: 'Circular' },
]}
value={layout}
onChange={setLayout}
size="sm"
/>
<button onClick={resetView}
className="text-xs px-3 py-1.5 rounded-lg border border-glass-border
text-text-secondary hover:text-text-primary hover:border-accent-cyan/40 transition-colors">
βΊ Fit
</button>
{method === 'ml' && (
<div className="flex items-center gap-2 text-[10px] text-text-secondary">
<span className="font-medium">Bootstrap:</span>
{[['β₯90', '#4ADE80'], ['70β89', '#a3e635'], ['50β69', '#fb923c'], ['<50', '#f87171']]
.map(([label, colour]) => (
<span key={label} className="flex items-center gap-0.5">
<span style={{ color: colour }}>β </span> {label}
</span>
))}
</div>
)}
<div className="flex gap-2 ml-auto">
{[
{ label: 'SVG', fn: handleExportSVG },
{ label: 'PNG', fn: handleExportPNG },
{ label: 'Newick', fn: handleExportNewick },
].map(({ label, fn }) => (
<button key={label} onClick={fn}
className="text-xs px-3 py-1.5 rounded-lg border border-glass-border
text-text-secondary hover:text-text-primary hover:border-accent-cyan/40 transition-colors">
β {label}
</button>
))}
</div>
</div>
{/* Collapse controls */}
<div className="flex gap-2 text-[11px]">
<button onClick={expandAll}
className="px-2.5 py-1 rounded border border-glass-border text-text-secondary hover:text-text-primary transition-colors">
Expand all
</button>
<button onClick={collapseAllInternal}
className="px-2.5 py-1 rounded border border-glass-border text-text-secondary hover:text-text-primary transition-colors">
Collapse all
</button>
<span className="text-text-secondary self-center opacity-60">
{hoveredId !== null ? 'Hover: path highlighted Β· ' : ''}
Double-click internal node to collapse/expand
</span>
</div>
{/* SVG */}
<div className="bg-surface-1 rounded-xl border border-glass-border overflow-hidden select-none"
style={{ maxHeight: '75vh' }}>
<svg
ref={svgRef}
viewBox={layout === 'rectangular'
? `0 0 ${SVG_W} ${treeData.height}`
: `0 0 ${CIRC_SIZE} ${CIRC_SIZE}`}
width="100%"
style={{ maxHeight: '70vh', background: treeCanvas, cursor: isDragging ? 'grabbing' : 'grab' }}
xmlns="http://www.w3.org/2000/svg"
onMouseDown={handleMouseDown}
onMouseMove={handleMouseMove}
onMouseUp={handleMouseUp}
onMouseLeave={handleMouseUp}
onClick={handleSvgClick}
>
<rect width="100%" height="100%" fill={treeCanvas} />
<g transform={`translate(${transform.x}, ${transform.y}) scale(${transform.scale})`}>
{layout === 'rectangular' ? (
<RectangularTree
nodes={treeData.nodes}
svgH={treeData.height}
maxDepth={treeData.maxDepth}
pathSet={pathSet}
selectedId={selectedId}
hoveredId={hoveredId}
onNodeHover={handleNodeHover}
onNodeClick={handleNodeClick}
onNodeDoubleClick={handleNodeDoubleClick}
/>
) : (
<CircularTree
nodes={treeData.nodes}
pathSet={pathSet}
selectedId={selectedId}
hoveredId={hoveredId}
onNodeHover={handleNodeHover}
onNodeClick={handleNodeClick}
onNodeDoubleClick={handleNodeDoubleClick}
/>
)}
</g>
</svg>
</div>
<p className="text-text-secondary text-xs">
{treeData.nodes.filter(n => n.children.length === 0).length} taxa Β·{' '}
{sequenceType === 'protein' ? 'protein' : 'nucleotide'} sequences
</p>
{/* Selected node info panel */}
{selectedNode && (
<NodeInfoPanel node={selectedNode} allNodes={treeData.nodes} />
)}
{alignment && (
<div className="border border-glass-border rounded-xl overflow-hidden">
<button
onClick={() => setShowAln(v => !v)}
className="w-full flex items-center justify-between px-4 py-3
text-text-secondary hover:text-text-primary transition-colors text-sm">
<span>Multiple Sequence Alignment</span>
<span className="text-xs opacity-60">{showAlignment ? 'β² hide' : 'βΌ show'}</span>
</button>
{showAlignment && (
<>
{alignmentStats && <AlignmentStatsBar stats={alignmentStats} className="px-4 pt-3" />}
<div className="p-4">
<AlignmentBlock alnFasta={alignment} className="max-h-60" />
</div>
</>
)}
</div>
)}
<div className="border border-glass-border rounded-xl overflow-hidden">
<button
onClick={() => setShowRaw(v => !v)}
className="w-full flex items-center justify-between px-4 py-3
text-text-secondary hover:text-text-primary transition-colors text-sm">
<span>Raw Newick</span>
<span className="text-xs opacity-60">{showRaw ? 'β² hide' : 'βΌ show'}</span>
</button>
{showRaw && (
<pre className="overflow-auto p-4 text-[11px] font-mono text-text-secondary
bg-surface-1 max-h-40 whitespace-pre-wrap break-all">
{newick}
</pre>
)}
</div>
</div>
)
}
|