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1fba539 | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 | from __future__ import annotations
import importlib.util
from pathlib import Path
def _load_case_module():
path = Path(__file__).resolve().parents[1] / "benchmark" / "case-studies" / "hbb-variant-mapping" / "run.py"
spec = importlib.util.spec_from_file_location("hbb_variant_case", path)
assert spec is not None and spec.loader is not None
module = importlib.util.module_from_spec(spec)
spec.loader.exec_module(module)
return module
def test_hbb_e7v_case_is_deterministic_and_mapped():
case = _load_case_module()
result = case.run_case()
assert result["status"] == "executed"
assert result["source"]["accession"] == "P68871"
assert result["source"]["sequence_length"] == 147
assert result["source"]["sequence_sha256"] == case.EXPECTED_WT_SHA256
assert result["variant"]["position"] == 7
assert result["variant"]["ref"] == "E"
assert result["variant"]["alt"] == "V"
assert result["variant"]["mutant_sequence_sha256"] == case.EXPECTED_MUTANT_SHA256
assert result["deterministic_result"]["alignment_position"] == 7
assert result["deterministic_result"]["reference_symbol"] == "E"
assert result["deterministic_result"]["sequence_count"] == 2
assert result["deterministic_result"]["alignment_length"] == 147
assert result["reproducibility"]["random_seed_required"] is False
assert "does not establish diagnostic validity" in result["scientific_boundary"]
def test_hbb_fixture_rejects_reference_drift():
case = _load_case_module()
assert case.sha256_text(case.HBB_WILDTYPE) == case.EXPECTED_WT_SHA256
mutant = case.build_mutant()
assert mutant[6] == "V"
assert case.sha256_text(mutant) == case.EXPECTED_MUTANT_SHA256
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