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| FROM python:3.11-slim | |
| RUN apt-get update && apt-get install -y --no-install-recommends \ | |
| build-essential gcc wget ca-certificates openbabel && \ | |
| rm -rf /var/lib/apt/lists/* | |
| # Download pre-compiled PhyML binary from bioconda | |
| RUN wget -qO /tmp/phyml.tar.bz2 \ | |
| https://anaconda.org/bioconda/phyml/3.3.20220408/download/linux-64/phyml-3.3.20220408-h9bc3f66_3.tar.bz2 && \ | |
| tar xjf /tmp/phyml.tar.bz2 -C /tmp && \ | |
| cp /tmp/bin/phyml /usr/local/bin/phyml && \ | |
| chmod +x /usr/local/bin/phyml && \ | |
| rm -rf /tmp/phyml.tar.bz2 /tmp/bin | |
| # Download pre-compiled AutoDock Vina binary from GitHub releases | |
| RUN wget -q "https://github.com/autodock/autodock-vina/releases/download/v1.2.5/vina_1.2.5_linux_x86_64" -O /usr/local/bin/vina && \ | |
| chmod +x /usr/local/bin/vina | |
| WORKDIR /app | |
| COPY requirements.txt . | |
| RUN pip install --no-cache-dir -r requirements.txt | |
| # primer3-py is optional (requires C compiler) — skip silently if it fails | |
| RUN pip install --no-cache-dir primer3-py>=2.0.3 2>/dev/null || echo "primer3-py skipped (optional)" | |
| COPY . . | |
| EXPOSE 7860 | |
| CMD ["uvicorn", "app.main:app", "--host", "0.0.0.0", "--port", "7860"] | |