fix: AlphaFold lookup for NCBI RefSeq accessions

- _lookup(): map NCBI RefSeq IDs to UniProt before querying AlphaFold API
- run(): skip cache for NCBI accessions (they need mapping, not caching)
- Fixes: AlphaFold 404 when BLAST returns NP_/XP_/YP_ accessions

bioai-platform/backend/app/tools/alphafold.py

@@ -14,10 +14,28 @@ class AlphaFoldTool(BaseTool):
         if not uniprot_accession:
             return {"error": "No UniProt accession provided", "structure_available": False}
 
+        # NCBI RefSeq accessions can't be cached as-is because we need
+        # to map them to UniProt first (AlphaFold only indexes by UniProt).
+        # Skip cache for NCBI IDs — the mapped UniProt result will be cached.
+        import re
+        is_ncbi = uniprot_accession[:3] in ("NP_", "XP_", "YP_", "WP_")
+        if is_ncbi:
+            return await self._lookup(uniprot_accession)
+
         result = await self._lookup(uniprot_accession)
         return result
 
     async def _lookup(self, accession: str) -> dict:
+        # AlphaFold only indexes by UniProt accessions. If this looks like
+        # an NCBI RefSeq ID, try mapping to UniProt first.
+        import re
+        is_ncbi = accession[:3] in ("NP_", "XP_", "YP_", "WP_")
+        if is_ncbi:
+            from app.services.sequence_utils import map_refseq_to_uniprot
+            mapped = await map_refseq_to_uniprot(accession)
+            if mapped:
+                accession = mapped
+
         url = f"{settings.ALPHAFOLD_DB_URL}/{accession}"
         async with httpx.AsyncClient(timeout=15) as client:
             resp = await client.get(url)