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app/services/experiment.py

@@ -120,9 +120,13 @@ def _input_sha256(sequence: str) -> str:
 
 def deterministic_seed(sequence: str, parameters: dict | None = None) -> int:
     """Deterministic random seed derived from input + params so a rerun with
-    identical inputs reproduces identical stochastic behavior."""
+    identical inputs reproduces identical stochastic behavior.
+
+    Masked to the signed 64-bit range so the value always fits a Postgres
+    bigint column (2^63-1), regardless of the input hash.
+    """
     payload = sequence.strip().upper() + repr(sorted((parameters or {}).items()))
-    return int.from_bytes(hashlib.sha256(payload.encode()).digest()[:8], "big")
+    return int.from_bytes(hashlib.sha256(payload.encode()).digest()[:8], "big") & 0x7FFFFFFFFFFFFFFF
 
 
 def make_experiment_id() -> str:

tests/test_experiment_provenance.py

@@ -154,6 +154,15 @@ class TestExperimentManager:
         assert a == b
         assert a != c
 
+    def test_deterministic_seed_fits_postgres_bigint(self, fake_sb):
+        # Regression: seed must never overflow a signed 64-bit bigint column
+        # (Postgres max is 2^63-1). The masking above guarantees it.
+        bigint_max = (1 << 63) - 1
+        for seq in ["MGHHHH", "FVNQHLCGSHLVEALYLVCGERGFFYTPKT", "MKWVTFISLL" * 5, "A" * 2000]:
+            for params in (None, {"fast_mode": True}, {"blast_params": {"database": "nr"}}):
+                seed = exp_svc.deterministic_seed(seq, params)
+                assert 0 <= seed <= bigint_max
+
     def test_fingerprint_fields(self, fake_sb):
         fp = exp_svc.build_fingerprint("MGHHHH", {"fast_mode": True})
         assert "git_commit" in fp