David Saylor commited on
Commit ·
499389d
1
Parent(s): 021283d
fixed cutoff to be 0.2 instead of 0.5
Browse files- CHRIS.py +1 -1
- static/COU.md +1 -1
- templates/report.html +2 -2
CHRIS.py
CHANGED
|
@@ -154,7 +154,7 @@ def calcexposure(MW, amount, vol, area, time, pIndex):
|
|
| 154 |
|
| 155 |
D = D * 3600.
|
| 156 |
tau = D * time / L ** 2.
|
| 157 |
-
if tau <= 0.
|
| 158 |
release = 2. * amount * np.sqrt(tau / np.pi)
|
| 159 |
else:
|
| 160 |
release = amount * (1. - (8. / (np.pi ** 2.)) * np.exp(-tau * np.pi ** 2. / 4.))
|
|
|
|
| 154 |
|
| 155 |
D = D * 3600.
|
| 156 |
tau = D * time / L ** 2.
|
| 157 |
+
if tau <= 0.2:
|
| 158 |
release = 2. * amount * np.sqrt(tau / np.pi)
|
| 159 |
else:
|
| 160 |
release = amount * (1. - (8. / (np.pi ** 2.)) * np.exp(-tau * np.pi ** 2. / 4.))
|
static/COU.md
CHANGED
|
@@ -48,7 +48,7 @@ CHRIS provides clinically relevant, yet still conservative, exposure dose estima
|
|
| 48 |
1. The polymer does not swell or degrade in-vivo, nor does the presence of CA impact the integrity of the polymer.
|
| 49 |
1. The total amount of CA is present in dilute concentrations (<= 2 % m/v) within the colored component.
|
| 50 |
1. The CA is homogeneously distributed throughout the polymer.
|
| 51 |
-
1. The smallest dimension of the colored device component is much greater than the size of any color additive particles that may be present (
|
| 52 |
|
| 53 |
While these assumptions are typically valid for color additive containing device components, users of CHRIS must confirm conformance to the underlying assumptions or provide supporting justification to ensure compliance for a given system. Further, CHRIS only enables system specific exposure estimates for nineteen (19) polymeric systems that are generally biostable (non-swelling and non-degrading) and contain less than 2 % m/v of a given CA. These polymers are listed below. To estimate CA release based on the model, the diffusion coefficient of the CA in the polymer matrix must be specified. For the nineteen (19) listed polymeric systems, a worst-case (upper bound) diffusion coefficient, as a function of additive molecular weight, has been established based on data from the literature. For polymer matrices that are not included in this list, CHRIS assigns an ultra-conservative diffusion coefficient that assumes the polymer has the properties of water. Note that the worst-case diffusion coefficient is only defined over a molecular weight range of 100 to 1100 g/mol. Therefore, for substances with a molecular weight > 1100 g/mol, the value of the diffusion coefficient assuming a molecular weight of 1100 g/mol can be used as a conservative value; for substances with a molecular weight < 100 g/mol, CHRIS currently cannot be used to estimate exposure.
|
| 54 |
|
|
|
|
| 48 |
1. The polymer does not swell or degrade in-vivo, nor does the presence of CA impact the integrity of the polymer.
|
| 49 |
1. The total amount of CA is present in dilute concentrations (<= 2 % m/v) within the colored component.
|
| 50 |
1. The CA is homogeneously distributed throughout the polymer.
|
| 51 |
+
1. The smallest dimension of the colored device component is much greater than the size of any color additive particles that may be present (<= 50x).
|
| 52 |
|
| 53 |
While these assumptions are typically valid for color additive containing device components, users of CHRIS must confirm conformance to the underlying assumptions or provide supporting justification to ensure compliance for a given system. Further, CHRIS only enables system specific exposure estimates for nineteen (19) polymeric systems that are generally biostable (non-swelling and non-degrading) and contain less than 2 % m/v of a given CA. These polymers are listed below. To estimate CA release based on the model, the diffusion coefficient of the CA in the polymer matrix must be specified. For the nineteen (19) listed polymeric systems, a worst-case (upper bound) diffusion coefficient, as a function of additive molecular weight, has been established based on data from the literature. For polymer matrices that are not included in this list, CHRIS assigns an ultra-conservative diffusion coefficient that assumes the polymer has the properties of water. Note that the worst-case diffusion coefficient is only defined over a molecular weight range of 100 to 1100 g/mol. Therefore, for substances with a molecular weight > 1100 g/mol, the value of the diffusion coefficient assuming a molecular weight of 1100 g/mol can be used as a conservative value; for substances with a molecular weight < 100 g/mol, CHRIS currently cannot be used to estimate exposure.
|
| 54 |
|
templates/report.html
CHANGED
|
@@ -37,8 +37,8 @@ This estimate was derived using solutions to the conservative plane sheet model
|
|
| 37 |
\[
|
| 38 |
M(\tau)= \left\{
|
| 39 |
\begin{array}{cr}
|
| 40 |
-
2 M_0 \sqrt{\tau/\pi} & \tau \leq 0.
|
| 41 |
-
M_0\left(1-8 \exp\left[-\tau \pi^2/4 \right]/\pi^2\right) & \tau > 0.
|
| 42 |
\end{array} \right.
|
| 43 |
\]
|
| 44 |
|
|
|
|
| 37 |
\[
|
| 38 |
M(\tau)= \left\{
|
| 39 |
\begin{array}{cr}
|
| 40 |
+
2 M_0 \sqrt{\tau/\pi} & \tau \leq 0.2 \\
|
| 41 |
+
M_0\left(1-8 \exp\left[-\tau \pi^2/4 \right]/\pi^2\right) & \tau > 0.2
|
| 42 |
\end{array} \right.
|
| 43 |
\]
|
| 44 |
|