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Running on Zero
Running on Zero
hardiksood21 commited on
Commit ·
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Parent(s): e9ef024
style: replace unrendered inline LaTeX dollar signs with clean unicode symbols in web UI
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app.py
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@@ -191,8 +191,8 @@ with gr.Blocks(title="VariantLLM | Clinical Variant Effect Prediction Engine") a
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$$\Delta \text{LLR} = \log P(x_i = \text{wt} \mid X_{-i}) - \log P(x_i = \text{mut} \mid X_{-i})$$
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- **Positive
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- **Neutral
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### Foundation Architecture
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- **Backbone**: Meta AI's `facebook/esm2_t6_8M_UR50D` (6-layer Multi-Head Self-Attention Transformer with Rotary Positional Embeddings).
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$$\Delta \text{LLR} = \log P(x_i = \text{wt} \mid X_{-i}) - \log P(x_i = \text{mut} \mid X_{-i})$$
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- **Positive ΔLLR (> 1.5)**: The wildtype amino acid is significantly more evolutionarily favored across the phylogenetic tree. The mutation disrupts biophysical stability or catalytic activity → **Pathogenic / Deleterious**.
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- **Neutral / Negative ΔLLR (≈ 0 or < 1.5)**: The substitution is evolutionarily tolerated → **Benign / Tolerated**.
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### Foundation Architecture
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- **Backbone**: Meta AI's `facebook/esm2_t6_8M_UR50D` (6-layer Multi-Head Self-Attention Transformer with Rotary Positional Embeddings).
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