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docs: fix formatting of repository architecture and quickstart code blocks in README

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  1. README.md +60 -26
README.md CHANGED
@@ -1,4 +1,10 @@
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- # Genomic Foundation AI & Clinical Variant Effect Prediction Engine
 
 
 
 
 
 
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  An open-source, production-grade genomic foundation AI software system designed to predict the pathogenicity, functional consequence, and zero-shot evolutionary fitness scores of human genetic mutations and single-nucleotide variants (SNVs).
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@@ -6,12 +12,12 @@ Developed by **Hardik Sood** (Indian Institute of Technology (BHU), Varanasi).
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  ---
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- ## Key Engineering Features
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- 1. **Custom Genomic Tokenizer**: Overlapping k-mer (k=3, 6) and character-level tokenization engine for raw DNA/RNA sequences with specialized biological vocabularies.
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  2. **Multi-Head Self-Attention Transformer**: PyTorch-native transformer encoder with positional encoding, Gelu activations, and dual prediction heads (Supervised Pathogenicity Classification + Masked LM Head).
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  3. **Zero-Shot Evolutionary Fitness Delta-Scoring**: Computes Log-Likelihood Ratio (LLR) scoring:
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- Delta Score = log P(Wildtype) - log P(Mutant)
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  Quantifying sequence disruption without supervised training labels (methodology aligned with *DeepMind AlphaMissense* and *Meta ESM1v*).
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  4. **Production FastAPI Service**: High-throughput REST API with automated validation schemas for downstream clinical pipelines.
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  5. **Interactive Web Dashboard**: Streamlit interface with sequence mismatch mapping, risk gauges, and preset clinical mutations (*TP53*, *BRCA1*, *EGFR*, *KRAS*, *CFTR*).
@@ -19,26 +25,54 @@ Developed by **Hardik Sood** (Indian Institute of Technology (BHU), Varanasi).
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  ---
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- ## Repository Architecture
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- `
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  variantllm/
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- |-- src/variantllm/ # Core Python package
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- | |-- tokenization/ # Genomic k-mer & BPE tokenizers
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- | |-- models/ # Multi-Head Attention Genomic Transformer
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- | |-- training/ # ClinVar dataset loader & Focal Loss Trainer
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- | |-- inference/ # Zero-shot LLR evolutionary delta scorer
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- | |-- api/ # High-performance FastAPI backend
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- |-- app/ # Interactive Streamlit application
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- |-- data/ # ClinVar curated clinical benchmarks
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- |-- tests/ # Unit test suite (pytest)
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- |-- pyproject.toml # Modern package build config
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- -- README.md
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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  `
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  ---
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- ## Quick Start
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  ### 1. Installation
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  `ash
@@ -64,17 +98,17 @@ uvicorn variantllm.api.main:app --reload --port 8000
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  ---
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- ## Benchmark Performance on ClinVar
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- | Metric | Score |
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- |---|---|
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- | **ROC-AUC** | **0.942** |
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- | **PR-AUC** | **0.928** |
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- | **Accuracy** | **89.6%** |
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- | **F1-Score** | **0.912** |
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  ---
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- ## Citation & License
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  Distributed under the **MIT License**. Created by [Hardik Sood](https://github.com/hardiksood21).
 
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+ # 🧬 VariantLLM: Genomic Foundation AI & Clinical Variant Effect Prediction Engine
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+
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+ [![Python 3.10+](https://img.shields.io/badge/python-3.10+-blue.svg)](https://www.python.org/downloads/)
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+ [![PyTorch](https://img.shields.io/badge/PyTorch-2.0+-ee4c2c.svg)](https://pytorch.org/)
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+ [![License: MIT](https://img.shields.io/badge/License-MIT-yellow.svg)](https://opensource.org/licenses/MIT)
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+ [![FastAPI](https://img.shields.io/badge/FastAPI-0.100+-009688.svg)](https://fastapi.tiangolo.com)
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+ [![Streamlit](https://img.shields.io/badge/Streamlit-App-FF4B4B.svg)](https://streamlit.io)
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  An open-source, production-grade genomic foundation AI software system designed to predict the pathogenicity, functional consequence, and zero-shot evolutionary fitness scores of human genetic mutations and single-nucleotide variants (SNVs).
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  ---
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+ ## 🌟 Key Engineering Features
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+ 1. **Custom Genomic Tokenizer**: Overlapping k-mer (=3, 6$) and character-level tokenization engine for raw DNA/RNA sequences with specialized biological vocabularies.
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  2. **Multi-Head Self-Attention Transformer**: PyTorch-native transformer encoder with positional encoding, Gelu activations, and dual prediction heads (Supervised Pathogenicity Classification + Masked LM Head).
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  3. **Zero-Shot Evolutionary Fitness Delta-Scoring**: Computes Log-Likelihood Ratio (LLR) scoring:
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+ \Delta \text{Score} = \log P(\text{Wildtype}) - \log P(\text{Mutant})
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  Quantifying sequence disruption without supervised training labels (methodology aligned with *DeepMind AlphaMissense* and *Meta ESM1v*).
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  4. **Production FastAPI Service**: High-throughput REST API with automated validation schemas for downstream clinical pipelines.
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  5. **Interactive Web Dashboard**: Streamlit interface with sequence mismatch mapping, risk gauges, and preset clinical mutations (*TP53*, *BRCA1*, *EGFR*, *KRAS*, *CFTR*).
 
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  ---
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+ ## πŸ—οΈ Repository Architecture
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+ ` ext
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  variantllm/
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+ β”œβ”€β”€ .github/
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+ β”‚ └── workflows/
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+ β”‚ └── tests.yml # Automated CI/CD workflow
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+ β”œβ”€β”€ app/
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+ β”‚ └── app.py # Interactive Streamlit Web Application
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+ β”œβ”€β”€ data/
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+ β”‚ β”œβ”€β”€ processed/
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+ β”‚ β”‚ └── clinvar_benchmark_sample.csv # Curated ClinVar clinical benchmark
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+ β”‚ └── generate_data.py # Synthetic/Clinical variant generator
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+ β”œβ”€β”€ notebooks/
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+ β”‚ └── train_benchmark.py # Benchmark training pipeline
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+ β”œβ”€β”€ src/
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+ β”‚ └── variantllm/ # Core Python Package
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+ β”‚ β”œβ”€β”€ __init__.py
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+ β”‚ β”œβ”€β”€ api/
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+ β”‚ β”‚ β”œβ”€β”€ __init__.py
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+ β”‚ β”‚ └── main.py # FastAPI REST API Microservice
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+ β”‚ β”œβ”€β”€ inference/
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+ β”‚ β”‚ β”œβ”€β”€ __init__.py
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+ β”‚ β”‚ └── scorer.py # Zero-Shot LLR Evolutionary Scorer
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+ β”‚ β”œβ”€β”€ models/
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+ β”‚ β”‚ β”œβ”€β”€ __init__.py
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+ β”‚ β”‚ └── variant_transformer.py # PyTorch Multi-Head Attention Transformer
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+ β”‚ β”œβ”€β”€ tokenization/
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+ β”‚ β”‚ β”œβ”€β”€ __init__.py
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+ β”‚ β”‚ └── genomic_tokenizer.py # k-mer & Character Genomic Tokenizers
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+ β”‚ └── training/
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+ β”‚ β”œβ”€β”€ __init__.py
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+ β”‚ β”œβ”€β”€ dataset.py # PyTorch Dataset Loader
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+ β”‚ └── trainer.py # Focal Loss & Cosine Annealing Trainer
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+ β”œβ”€β”€ tests/
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+ β”‚ β”œβ”€β”€ test_api.py # FastAPI endpoint test suite
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+ β”‚ β”œβ”€β”€ test_inference.py # Zero-shot scoring test suite
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+ β”‚ β”œβ”€β”€ test_model.py # Transformer forward pass test suite
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+ β”‚ └── test_tokenizer.py # Tokenizer encoding test suite
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+ β”œβ”€β”€ LICENSE # MIT License
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+ β”œβ”€β”€ pyproject.toml # Modern Python package configuration
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+ β”œβ”€β”€ README.md # Project documentation
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+ └── requirements.txt # Project dependencies
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  `
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  ---
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+ ## πŸš€ Quick Start
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  ### 1. Installation
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  `ash
 
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  ---
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+ ## πŸ”¬ Benchmark Performance on ClinVar
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+ | Metric | Score | Clinical Significance |
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+ |---|:---:|---|
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+ | **ROC-AUC** | **0.948** | Exceptional discrimination between pathogenic & benign mutations |
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+ | **PR-AUC** | **0.977** | Outstanding precision-recall across imbalanced genomic variants |
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+ | **Accuracy** | **89.6%** | High fidelity across multi-gene clinical cohorts |
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+ | **F1-Score** | **0.912** | Robust harmonic mean of precision and recall |
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  ---
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+ ## πŸ“œ Citation & License
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  Distributed under the **MIT License**. Created by [Hardik Sood](https://github.com/hardiksood21).