Spaces:
Paused
Paused
File size: 12,274 Bytes
ff34739 8ffc9f7 ff34739 ee0c38c b5d4bb5 ff34739 8ffc9f7 37a1395 8ffc9f7 37a1395 8ffc9f7 bd7cf06 b303f51 bd7cf06 b303f51 bd7cf06 b303f51 37a1395 b303f51 bd7cf06 b303f51 8ffc9f7 b303f51 8ffc9f7 b303f51 8ffc9f7 ff34739 b303f51 ff34739 b303f51 ff34739 b303f51 ff34739 b5d4bb5 ff34739 b5d4bb5 ff34739 | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 | import path from "node:path";
import { promises as fs } from "node:fs";
import { assets, DEFAULT_MODEL, PYTHON, REPO_ROOT } from "./config";
import { inProject, runDir } from "./paths";
import { allocateRun, getProject, getRun, updateRun } from "./store";
import { killGroup, spawnLogged } from "./spawn";
import { generateAllFixes } from "./remediate";
import { appendConversation } from "./chat";
import { knowledgeFor } from "./reportHtml";
import type { QcReport, RunRecord, StepName, StepStatus } from "./types";
async function fileExists(p: string): Promise<boolean> {
try {
await fs.access(p);
return true;
} catch {
return false;
}
}
/**
* Allocate + launch a QC run against the project's confirmed spec and reads.
* Shared by POST /runs and POST /confirm-spec. Returns the new runId, or an error.
*/
export async function startQcRun(
projectId: string,
opts: {
useLlm?: boolean;
fastqSource?: "control" | "sim" | "upload" | "remediated";
maxReads?: number | null;
} = {},
): Promise<{ runId: string } | { error: string }> {
let project;
try {
project = await getProject(projectId);
} catch {
return { error: "project not found" };
}
const useLlm = opts.useLlm !== false;
const fastqSource = (
["control", "upload", "remediated"] as const
).includes(opts.fastqSource as never)
? (opts.fastqSource as "control" | "upload" | "remediated")
: "sim";
const maxReads =
typeof opts.maxReads === "number" && opts.maxReads > 0 ? Math.floor(opts.maxReads) : null;
// Spec: the project's extracted spec if present, else the packaged reference.
const specSource =
project.activeSpecPath && (await fileExists(inProject(projectId, project.activeSpecPath)))
? inProject(projectId, project.activeSpecPath)
: assets.referenceSpec;
// Nanopore = a single long-read file (no R2, no whitelist); short-read = paired R1/R2.
const single = project.platform === "nanopore";
let r1: string, r2: string;
if (fastqSource === "upload") {
const fq = project.inputs.fastq;
if (!fq || fq.source !== "upload" || !fq.r1 || (!single && !fq.r2)) {
return {
error: single
? "upload your reads FASTQ before running"
: "upload both R1 and R2 FASTQ before running on your reads",
};
}
r1 = inProject(projectId, fq.r1);
r2 = single ? "" : inProject(projectId, fq.r2!);
} else if (fastqSource === "remediated") {
// Cleaned reads written by a remediation script.
r1 = inProject(projectId, single ? "remediated/reads.fastq.gz" : "remediated/R1.fastq.gz");
r2 = single ? "" : inProject(projectId, "remediated/R2.fastq.gz");
} else {
r1 = fastqSource === "control" ? assets.control.r1 : assets.sim.r1;
r2 = fastqSource === "control" ? assets.control.r2 : assets.sim.r2;
}
const whitelist = !single && (await fileExists(assets.whitelist)) ? assets.whitelist : null;
// Ground-truth labels only exist for the simulated (short-read) dataset (enables the eval panel).
const labels =
!single && fastqSource === "sim" && (await fileExists(assets.sim.labels)) ? assets.sim.labels : null;
if (!(await fileExists(r1)) || (!single && !(await fileExists(r2)))) {
return { error: `reads not found for source "${fastqSource}"` };
}
const run = await allocateRun(projectId, {
pipeline: ["qc"],
options: {
useLlm,
maxReads,
withLabels: !!labels,
withWhitelist: !!whitelist,
fastqSource,
platform: project.platform,
},
inputsSnapshot: { specPath: "", r1, r2, whitelist, labels },
steps: { qc: { name: "qc", status: "queued", log: "logs/qc.log" } },
overallStatus: "queued",
});
// Snapshot the spec into the run dir for immutable provenance, then record its path.
const snapshot = path.join(runDir(projectId, run.id), "spec.json");
await fs.copyFile(specSource, snapshot);
await updateRun(projectId, run.id, (r) => ({
...r,
inputsSnapshot: { ...r.inputsSnapshot, specPath: snapshot },
}));
launchRun(projectId, run.id);
return { runId: run.id };
}
/** In-memory live-process registry (for cancel) — run.json remains the durable truth. */
const livePids = new Map<string, number>(); // `${projectId}:${runId}:${step}` -> pid
const canceled = new Set<string>(); // `${projectId}:${runId}`
const stepKey = (p: string, r: string, s: string) => `${p}:${r}:${s}`;
const runKey = (p: string, r: string) => `${p}:${r}`;
const now = () => new Date().toISOString();
// ---- crude global concurrency cap (pipeline steps stream whole FASTQs + cost money) ----
const MAX_ACTIVE = 2;
let active = 0;
const waiters: Array<() => void> = [];
async function acquire(): Promise<void> {
if (active < MAX_ACTIVE) {
active++;
return;
}
await new Promise<void>((res) => waiters.push(res)); // slot handed over on release
}
function release(): void {
const w = waiters.shift();
if (w) w();
else active--;
}
// ---- argv construction per step (uses the granular module CLIs, never the wrapper) ----
function buildArgs(step: StepName, run: RunRecord, dir: string): string[] {
const snap = run.inputsSnapshot;
const jsonOut = path.join(dir, "qc_report.json");
switch (step) {
case "qc":
// Nanopore: the single-long-read QC engine (no --r2 / --whitelist / --max-reads).
if (run.options.platform === "nanopore") {
return [
"-m",
"qc.nanopore",
"--spec",
snap.specPath,
"--reads",
snap.r1,
"--json-out",
jsonOut,
"--model",
DEFAULT_MODEL,
...(snap.labels ? ["--labels", snap.labels] : []),
...(run.options.useLlm ? [] : ["--no-llm"]),
];
}
return [
"-m",
"qc",
"run",
"--spec",
snap.specPath,
"--r1",
snap.r1,
"--r2",
snap.r2,
"--json-out",
jsonOut,
"--model",
DEFAULT_MODEL,
...(snap.whitelist ? ["--whitelist", snap.whitelist] : []),
...(snap.labels ? ["--labels", snap.labels] : []),
...(run.options.useLlm ? [] : ["--no-llm"]),
...(run.options.maxReads ? ["--max-reads", String(run.options.maxReads)] : []),
];
default:
// extract / simulate wired in Phase 2
throw new Error(`step not implemented: ${step}`);
}
}
async function readQcOverall(dir: string): Promise<QcReport["overall"] | null> {
try {
const report = JSON.parse(
await fs.readFile(path.join(dir, "qc_report.json"), "utf8"),
) as QcReport;
return report.overall ?? null;
} catch {
return null;
}
}
async function runStep(
projectId: string,
runId: string,
step: StepName,
): Promise<StepStatus> {
const dir = runDir(projectId, runId);
const logFile = path.join(dir, "logs", `${step}.log`);
const run = await getRun(projectId, runId);
const args = buildArgs(step, run, dir);
await updateRun(projectId, runId, (r) => ({
...r,
steps: {
...r.steps,
[step]: { ...r.steps[step]!, status: "running", startedAt: now() },
},
}));
const started = Date.now();
const proc = spawnLogged({ cmd: PYTHON, args, cwd: REPO_ROOT, logFile });
livePids.set(stepKey(projectId, runId, step), proc.pid);
await updateRun(projectId, runId, (r) => ({
...r,
steps: { ...r.steps, [step]: { ...r.steps[step]!, pid: proc.pid } },
}));
const code = await proc.done;
livePids.delete(stepKey(projectId, runId, step));
const durationMs = Date.now() - started;
const wasCanceled = canceled.has(runKey(projectId, runId));
const status: StepStatus = wasCanceled ? "canceled" : code === 0 ? "succeeded" : "failed";
const overall = step === "qc" && status === "succeeded" ? await readQcOverall(dir) : undefined;
await updateRun(projectId, runId, (r) => ({
...r,
overall: overall !== undefined ? overall : r.overall,
steps: {
...r.steps,
[step]: {
...r.steps[step]!,
status,
exitCode: code,
finishedAt: now(),
durationMs,
error:
status === "failed"
? `${step} exited with code ${code} — see the log`
: undefined,
},
},
}));
return status;
}
async function driveRun(projectId: string, runId: string): Promise<void> {
await acquire();
try {
const run = await updateRun(projectId, runId, (r) => ({
...r,
overallStatus: "running",
startedAt: now(),
}));
for (const step of run.pipeline) {
if (canceled.has(runKey(projectId, runId))) {
await finalize(projectId, runId, "canceled");
return;
}
const status = await runStep(projectId, runId, step);
if (status !== "succeeded") {
await finalize(projectId, runId, status === "canceled" ? "canceled" : "failed");
return;
}
}
await finalize(projectId, runId, "succeeded");
} finally {
canceled.delete(runKey(projectId, runId));
release();
}
}
/** A conversational diagnosis + suggested-fix summary from the report (posted after each QC run). */
function buildDiagnosisMessage(report: QcReport): string {
const issues = (report.findings ?? []).filter((f) => f.verdict === "fail" || f.verdict === "warn");
const verdict = (report.overall ?? "").toUpperCase();
const lines: string[] = [`**QC complete — overall ${verdict || "done"}.**`];
const plan = report.plan;
if (plan?.diagnosis) lines.push(plan.diagnosis);
else if (plan?.root_cause) lines.push(`Likely root cause: ${plan.root_cause}.`);
if (issues.length) {
lines.push("", "**Issues & suggested fixes:**");
for (const f of issues.slice(0, 6)) {
const inlineFix = /Fix:/i.test(f.detail);
const fix = inlineFix ? null : knowledgeFor(f.check_id)?.fix ?? null;
lines.push(`- **${f.title}** — ${f.detail}${fix ? `\n _Suggested fix:_ ${fix}` : ""}`);
}
} else {
lines.push("", "All checks passed — the reads are consistent with the expected structure.");
}
lines.push(
"",
"The full report (root cause + suggested fix per issue) is open in the viewer. Any " +
"computationally-fixable issue also appears in the **Computational fixes** panel below — tick " +
"them and Apply to clean the reads and re-score.",
);
return lines.join("\n");
}
async function finalize(projectId: string, runId: string, status: StepStatus): Promise<void> {
if (status === "succeeded") {
try {
const report = JSON.parse(
await fs.readFile(path.join(runDir(projectId, runId), "qc_report.json"), "utf8"),
) as QcReport;
// Post the diagnosis + suggested fixes into the conversation (not only in the report). Awaited
// BEFORE the status flips so the client's post-run hydrate always sees it.
await appendConversation(projectId, [
{ role: "assistant", text: buildDiagnosisMessage(report), ts: now() },
]);
// Eager remediation (fire-and-forget): only for a first-pass run, not a re-QC on cleaned reads.
const cur = await getRun(projectId, runId);
if (cur.options.fastqSource !== "remediated") generateAllFixes(projectId, report);
} catch {
/* best effort — diagnosis/remediation are optional */
}
}
await updateRun(projectId, runId, (r) => ({
...r,
overallStatus: status,
finishedAt: now(),
}));
}
/** Fire-and-forget launcher. The HTTP request returns immediately; this drives to completion. */
export function launchRun(projectId: string, runId: string): void {
void driveRun(projectId, runId).catch(async (err) => {
try {
await updateRun(projectId, runId, (r) => ({
...r,
overallStatus: "failed",
finishedAt: now(),
}));
} catch {
/* best effort */
}
console.error(`run ${projectId}/${runId} crashed:`, err);
});
}
/** Request cancellation: flag the run and kill any live step's process group. */
export function cancelRun(projectId: string, runId: string): boolean {
canceled.add(runKey(projectId, runId));
let killed = false;
for (const [k, pid] of livePids) {
if (k.startsWith(`${projectId}:${runId}:`)) {
killGroup(pid);
killed = true;
}
}
return killed;
}
|