Luca Celebrano commited on
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docs: sync latest 5-module portal, bio.tools, Bioconda, BioContainers and Springer Nature citation
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README.md
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Interactive simulation portal for biophysical reaction-diffusion drug transport modeling, post-ADAURA recurrence kinetics, clinical survival stratification, and the **Bedside Composite Resistance Index (CRI)** in *EGFR*-mutant lung adenocarcinoma.
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* **Research Square Preprint (Springer Nature):** [10.21203/rs.3.rs-11530312/v1](https://doi.org/10.21203/rs.3.rs-11530312/v1)
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* **Master Archival DOI (Zenodo):** [10.5281/zenodo.23754999](https://doi.org/10.5281/zenodo.23754999)
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* **Primary Dataset:** [`Lucace/mskcc-lung-adenocarcinoma-spatial-cohort`](https://huggingface.co/datasets/Lucace/mskcc-lung-adenocarcinoma-spatial-cohort) ($N = 604$ MSKCC 2020 cohort)
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* **GitHub Master Repository:** [`Lukecele/spatial-continuum-oncology`](https://github.com/Lukecele/spatial-continuum-oncology)
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* **Biophysical Reaction-Diffusion Repository:** [`Lukecele/spatial-oncology-master`](https://github.com/Lukecele/spatial-oncology-master)
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### Author & Academic Affiliation
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**Luca Celebrano**, Medical Student / MD Candidate
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Interactive simulation portal for biophysical reaction-diffusion drug transport modeling, post-ADAURA recurrence kinetics, clinical survival stratification, and the **Bedside Composite Resistance Index (CRI)** in *EGFR*-mutant lung adenocarcinoma.
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* **Research Square Preprint (Springer Nature):** [10.21203/rs.3.rs-11530312/v1](https://doi.org/10.21203/rs.3.rs-11530312/v1)
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* **Master Archival DOI (CERN Zenodo):** [10.5281/zenodo.23754999](https://doi.org/10.5281/zenodo.23754999)
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* **ELIXIR bio.tools Registry:** [`biotools:spatial-continuum-oncology`](https://bio.tools/spatial-continuum-oncology)
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* **Official Bioconda Package:** [`bioconda/spatial-continuum`](https://anaconda.org/bioconda/spatial-continuum)
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* **Official BioContainers:** Docker (`quay.io/biocontainers/spatial-continuum:1.0.2--pyhdfd78af_0`) & Singularity (`depot.galaxyproject.org`)
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* **Primary Dataset:** [`Lucace/mskcc-lung-adenocarcinoma-spatial-cohort`](https://huggingface.co/datasets/Lucace/mskcc-lung-adenocarcinoma-spatial-cohort) ($N = 604$ MSKCC 2020 cohort)
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* **GitHub Master Repository:** [`Lukecele/spatial-continuum-oncology`](https://github.com/Lukecele/spatial-continuum-oncology)
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* **Biophysical Reaction-Diffusion Repository:** [`Lukecele/spatial-oncology-master`](https://github.com/Lukecele/spatial-oncology-master)
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---
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### Citation
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If you use this biophysical model, web simulator, or the Bedside CRI engine, please cite:
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```bibtex
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@article{celebrano2026spatialcontinuum,
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title={Conditions for Pharmacological Sanctuaries in Perivascular Tumour Cords: A Reaction–Diffusion Analysis, a Regrowth-Kinetics Identity, and a Descriptive Survival Analysis of Histologic Subtype in Resected Lung Adenocarcinoma},
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author={Celebrano, Luca},
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journal={Research Square (Springer Nature)},
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year={2026},
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doi={10.21203/rs.3.rs-11530312/v1},
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url={https://doi.org/10.21203/rs.3.rs-11530312/v1},
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institution={Department of Clinical Medicine and Surgery, School of Medicine, Università degli Studi di Napoli Federico II}
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}
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```
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### Author & Academic Affiliation
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**Luca Celebrano**, Medical Student / MD Candidate
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